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Overview

ID MAG03988
Name TLS2_bin.20
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Chloroflexota
Class Limnocylindria
Order QHBO01
Family QHBO01
Genus JACDBZ01
Species JACDBZ01 sp035463095
Assembly information
Completeness (%) 67.2
Contamination (%) 1.15
GC content (%) 71.0
N50 (bp) 12,016
Genome size (bp) 1,572,295

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1456

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1020126_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 3.368e-217 699.0
TLS2_k127_1020126_1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335,K18331 - 1.12.1.3,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 387.0
TLS2_k127_1020126_10 Thioredoxin-like [2Fe-2S] ferredoxin K00334,K03388 - 1.6.5.3,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000003234 99.0
TLS2_k127_1020126_11 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000001425 89.0
TLS2_k127_1020126_12 GTP binding - - - 0.00000000001615 72.0
TLS2_k127_1020126_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 354.0
TLS2_k127_1020126_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 303.0
TLS2_k127_1020126_4 UPF0126 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000184 263.0
TLS2_k127_1020126_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000001937 201.0
TLS2_k127_1020126_6 NADH-quinone oxidoreductase K00341 - 1.6.5.3 0.0000000000000000000000000000000000001128 153.0
TLS2_k127_1020126_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000001142 120.0
TLS2_k127_1020126_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000001133 105.0
TLS2_k127_1020126_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000003314 96.0
TLS2_k127_1030863_0 DNA polymerase III alpha subunit K02337,K14162 - 2.7.7.7 0.0 1065.0
TLS2_k127_1030863_1 lactoylglutathione lyase activity K01724 - 4.2.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 302.0
TLS2_k127_1030863_2 AAA domain, putative AbiEii toxin, Type IV TA system K10010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 306.0
TLS2_k127_1030863_3 PFAM bifunctional deaminase-reductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001132 274.0
TLS2_k127_1030863_4 COG0765 ABC-type amino acid transport system permease component K02029,K10009,K16962 - - 0.0000000000000000000000000000000000000000000000000000000000002256 217.0
TLS2_k127_1030863_5 PFAM NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000003205 204.0
TLS2_k127_1030863_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000005296 97.0
TLS2_k127_1030863_7 Molecular chaperone K03686 - - 0.000000001862 68.0
TLS2_k127_1030863_8 - - - - 0.00002493 53.0
TLS2_k127_1030863_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.0001312 50.0
TLS2_k127_1045849_0 Acyl-CoA dehydrogenase, N-terminal domain K16173 - 1.3.99.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 543.0
TLS2_k127_1045849_1 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007959 464.0
TLS2_k127_1045849_10 - - - - 0.00001687 55.0
TLS2_k127_1045849_2 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 409.0
TLS2_k127_1045849_3 tRNA synthetases class I (C) catalytic domain K01883,K15526 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16,6.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 374.0
TLS2_k127_1045849_4 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 368.0
TLS2_k127_1045849_5 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 349.0
TLS2_k127_1045849_6 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007605 296.0
TLS2_k127_1045849_7 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000035 301.0
TLS2_k127_1045849_8 PFAM ornithine cyclodeaminase mu-crystallin K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000004483 228.0
TLS2_k127_1045849_9 - - - - 0.0000000000000001223 86.0
TLS2_k127_105085_0 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008898 330.0
TLS2_k127_105085_1 Thimet oligopeptidase K01392,K01393 GO:0000209,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005829,GO:0006464,GO:0006508,GO:0006518,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0016567,GO:0016787,GO:0019538,GO:0023052,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032446,GO:0033218,GO:0034641,GO:0035556,GO:0036211,GO:0042277,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0070013,GO:0070647,GO:0071704,GO:0140096,GO:1901564 3.4.24.15,3.4.24.16 0.00000000000000000000000000000000000000000000000001395 185.0
TLS2_k127_105085_2 Sigma-70, region 4 - - - 0.0000000000000000003582 96.0
TLS2_k127_105085_3 - - - - 0.0009476 50.0
TLS2_k127_108271_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 9.358e-195 630.0
TLS2_k127_108271_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000552 526.0
TLS2_k127_108271_10 negative regulation of DNA recombination K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000001335 103.0
TLS2_k127_108271_11 OHCU decarboxylase - - - 0.000000000000000000003568 98.0
TLS2_k127_108271_2 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K05365 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006818 348.0
TLS2_k127_108271_3 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 319.0
TLS2_k127_108271_4 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000107 251.0
TLS2_k127_108271_5 PFAM DoxX family protein - - - 0.000000000000000000000000000000000000000000000000000000001044 213.0
TLS2_k127_108271_6 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000003611 159.0
TLS2_k127_108271_7 PFAM CoA-binding domain protein K06929 - - 0.00000000000000000000000000000000016 148.0
TLS2_k127_108271_8 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000001268 138.0
TLS2_k127_108271_9 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000001036 134.0
TLS2_k127_1101882_0 glutamate dehydrogenase [NAD(P)+] activity K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 486.0
TLS2_k127_1101882_1 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 481.0
TLS2_k127_1101882_2 Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 365.0
TLS2_k127_1101882_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000797 237.0
TLS2_k127_1101882_4 histidine kinase dimerisation and phosphoacceptor region K03406,K07673,K07675 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000001275 244.0
TLS2_k127_1101882_5 Transcriptional regulator - - - 0.0000000000000001803 85.0
TLS2_k127_1101882_6 His Kinase A (phosphoacceptor - - - 0.00000000000001056 84.0
TLS2_k127_1101882_7 Multicopper oxidase K00368 - 1.7.2.1 0.0000000004596 73.0
TLS2_k127_1101882_8 - - - - 0.0000917 51.0
TLS2_k127_1101882_9 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.0004837 51.0
TLS2_k127_1113488_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 494.0
TLS2_k127_1113488_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004864 375.0
TLS2_k127_1113488_10 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 GO:0008150,GO:0040007 3.1.26.5 0.00000000001788 72.0
TLS2_k127_1113488_11 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000002265 64.0
TLS2_k127_1113488_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 331.0
TLS2_k127_1113488_3 cell division ATP-binding protein FtsE K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001455 289.0
TLS2_k127_1113488_4 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000002113 246.0
TLS2_k127_1113488_5 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000004168 182.0
TLS2_k127_1113488_6 Membrane protein insertase, YidC Oxa1 family K03217 - - 0.000000000000000000000000000000000001219 153.0
TLS2_k127_1113488_7 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation K09811 - - 0.0000000000000000000000000000000001624 143.0
TLS2_k127_1113488_8 R3H domain protein K06346 - - 0.00000000000000000000000005331 120.0
TLS2_k127_1113488_9 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000005251 100.0
TLS2_k127_1115838_0 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 9.425e-208 670.0
TLS2_k127_1115838_1 Zinc-binding dehydrogenase K00008,K00148,K18369 - 1.1.1.14,1.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 518.0
TLS2_k127_1115838_2 glycogen (starch) synthase activity K16148 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 2.4.1.342 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000936 506.0
TLS2_k127_1115838_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 478.0
TLS2_k127_1115838_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000002905 134.0
TLS2_k127_1115838_5 Domain of unknown function (DUF4260) - - - 0.000000000000000000000007419 118.0
TLS2_k127_1115838_6 Domain of unknown function (DUF4342) - - - 0.0000000000000000000002405 99.0
TLS2_k127_1115838_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000001559 94.0
TLS2_k127_1115838_8 PFAM response regulator receiver - - - 0.000004992 56.0
TLS2_k127_1139130_0 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004808 547.0
TLS2_k127_1139130_1 PFAM Luciferase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009624 397.0
TLS2_k127_1139130_2 Zn-dependent - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007824 380.0
TLS2_k127_1139130_3 2-polyprenyl-6-methoxyphenol K05712 - 1.14.13.127 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 389.0
TLS2_k127_1139130_4 trehalose synthase K05343 - 3.2.1.1,5.4.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000007293 259.0
TLS2_k127_1139130_5 Transcriptional regulator - - - 0.0000000000000000000000000000000000126 145.0
TLS2_k127_1139130_6 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000002242 99.0
TLS2_k127_1139130_7 - - - - 0.000000000000002506 85.0
TLS2_k127_1139130_8 - - - - 0.0001597 53.0
TLS2_k127_1199341_0 TIGRFAM ammonium transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009202 458.0
TLS2_k127_1199341_1 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005015 447.0
TLS2_k127_1199341_10 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000002014 127.0
TLS2_k127_1199341_11 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000009717 104.0
TLS2_k127_1199341_12 Ribosomal protein S21 K02970 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000008377 83.0
TLS2_k127_1199341_13 FAD-dependent oxidoreductase K09471 - - 0.00001334 57.0
TLS2_k127_1199341_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 398.0
TLS2_k127_1199341_3 7TM-HD extracellular K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 371.0
TLS2_k127_1199341_4 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002513 319.0
TLS2_k127_1199341_5 Methylates ribosomal protein L11 K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000000003803 245.0
TLS2_k127_1199341_6 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000009133 175.0
TLS2_k127_1199341_7 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - - 0.000000000000000000000000000000000000000006516 169.0
TLS2_k127_1199341_8 HIT domain K02503 - - 0.0000000000000000000000000000000000006349 146.0
TLS2_k127_1199341_9 YqeY-like protein K09117 - - 0.000000000000000000000000000000168 129.0
TLS2_k127_1235898_0 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009222 573.0
TLS2_k127_1235898_1 NMT1/THI5 like K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 363.0
TLS2_k127_1235898_2 ABC-type nitrate sulfonate bicarbonate transport system ATPase component K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008728 324.0
TLS2_k127_1235898_3 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000001865 198.0
TLS2_k127_1235898_4 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000002977 190.0
TLS2_k127_1235898_5 Belongs to the sigma-70 factor family K03088 - - 0.000000000000000000006537 100.0
TLS2_k127_1235898_6 Acetyltransferase (GNAT) domain - - - 0.00000000000001151 83.0
TLS2_k127_1245634_0 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 521.0
TLS2_k127_1245634_1 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 483.0
TLS2_k127_1250188_0 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 425.0
TLS2_k127_1250188_1 Belongs to the dCTP deaminase family K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000002507 263.0
TLS2_k127_1250188_2 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000002301 174.0
TLS2_k127_1250188_3 PFAM Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000001823 184.0
TLS2_k127_1250188_4 Thioredoxin-like - - - 0.0000000000000000000001647 105.0
TLS2_k127_1250188_5 Glutaredoxin-like domain (DUF836) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000003499 57.0
TLS2_k127_1250188_6 FAD binding domain - - - 0.000002599 50.0
TLS2_k127_1250188_7 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.00001778 53.0
TLS2_k127_1264635_0 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007044 428.0
TLS2_k127_1264635_1 Cell cycle protein K03588,K05364,K05837 GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 340.0
TLS2_k127_1264635_2 Cell division protein FtsI penicillin-binding protein K05364 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007081 273.0
TLS2_k127_1264635_3 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000003453 215.0
TLS2_k127_1264635_4 PFAM Forkhead-associated protein - - - 0.000000000000000000000000000000000000000008112 164.0
TLS2_k127_1264635_5 PFAM Forkhead-associated protein - - - 0.00000000000000000133 91.0
TLS2_k127_1264635_6 COG1305 Transglutaminase-like enzymes - - - 0.00000005193 65.0
TLS2_k127_1264635_7 Double zinc ribbon - - - 0.0002001 52.0
TLS2_k127_1270715_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 580.0
TLS2_k127_1270715_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 496.0
TLS2_k127_1270715_10 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000001266 167.0
TLS2_k127_1270715_11 type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis - - - 0.00000000000000000000000000000000000001912 156.0
TLS2_k127_1270715_12 GyrI-like small molecule binding domain - - - 0.0000000000000000000000000000000003852 139.0
TLS2_k127_1270715_13 3-demethylubiquinone-9 3-O-methyltransferase activity K03428 - 2.1.1.11 0.0000000000000000000000000000016 132.0
TLS2_k127_1270715_14 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000002624 81.0
TLS2_k127_1270715_15 DsrE/DsrF-like family - - - 0.000000000002561 70.0
TLS2_k127_1270715_16 helix_turn_helix, Lux Regulon - - - 0.0000000001236 72.0
TLS2_k127_1270715_17 Copper binding proteins, plastocyanin/azurin family - - - 0.000001835 61.0
TLS2_k127_1270715_18 Transglycosylase associated protein - - - 0.00002281 51.0
TLS2_k127_1270715_19 - - - - 0.0004279 51.0
TLS2_k127_1270715_2 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008445 500.0
TLS2_k127_1270715_3 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 444.0
TLS2_k127_1270715_4 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 361.0
TLS2_k127_1270715_5 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008603 323.0
TLS2_k127_1270715_6 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003274 257.0
TLS2_k127_1270715_7 PspA/IM30 family K03969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002085 264.0
TLS2_k127_1270715_8 TPM domain - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000001891 234.0
TLS2_k127_1270715_9 PFAM GCN5-related N-acetyltransferase K06976 - - 0.00000000000000000000000000000000000000000000000005003 189.0
TLS2_k127_127186_0 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 576.0
TLS2_k127_127186_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 417.0
TLS2_k127_127186_10 Sarcosine oxidase K00303 - 1.5.3.1 0.0000002525 63.0
TLS2_k127_127186_2 Bacterial extracellular solute-binding protein K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 335.0
TLS2_k127_127186_3 ABC-type spermidine putrescine transport system, permease component I K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 321.0
TLS2_k127_127186_4 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 297.0
TLS2_k127_127186_5 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 291.0
TLS2_k127_127186_6 regulatory protein - - - 0.00000000000000000000000000000000000000000000000000759 194.0
TLS2_k127_127186_7 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.000000000000000000000000000000000000001224 153.0
TLS2_k127_127186_8 PFAM flavin reductase domain protein FMN-binding K21185 - - 0.0000000000000000000000000000003966 128.0
TLS2_k127_127186_9 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.00000000008766 73.0
TLS2_k127_1351824_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000004394 178.0
TLS2_k127_1351824_1 iron dependent repressor K03709 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000325 150.0
TLS2_k127_1351824_2 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000000000000000000000000171 150.0
TLS2_k127_1351824_3 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000003992 120.0
TLS2_k127_1351824_4 esterase of the alpha-beta hydrolase superfamily K07001 GO:0003674,GO:0003824,GO:0016787 - 0.000004035 51.0
TLS2_k127_1355019_0 PFAM ABC transporter related K05847 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009819 449.0
TLS2_k127_1355019_1 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000006595 271.0
TLS2_k127_1355019_10 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000004696 99.0
TLS2_k127_1355019_11 TPM domain K06872 - - 0.0000008196 63.0
TLS2_k127_1355019_2 B12- binding domain protein K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000004791 186.0
TLS2_k127_1355019_3 Binding-protein-dependent transport system inner membrane component K05846 - - 0.000000000000000000000000000000000000000000000000001061 190.0
TLS2_k127_1355019_4 Substrate binding domain of ABC-type glycine betaine transport system K05845 - - 0.0000000000000000000000000000000000000000000000000114 195.0
TLS2_k127_1355019_5 Binding-protein-dependent transport system inner membrane component K05846 - - 0.000000000000000000000000000000000000000000000000116 186.0
TLS2_k127_1355019_6 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000003801 147.0
TLS2_k127_1355019_7 integral membrane protein - - - 0.00000000000000000000000000000956 135.0
TLS2_k127_1355019_8 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000007556 128.0
TLS2_k127_1355019_9 Acid phosphatase homologues - - - 0.00000000000000000000000002173 117.0
TLS2_k127_1356388_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 409.0
TLS2_k127_1356388_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007069 417.0
TLS2_k127_1356388_2 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000000002375 247.0
TLS2_k127_1356388_3 Protein of unknown function (DUF554) K07150 - - 0.0000000000000000000000000000000000000000000000000000000000001451 231.0
TLS2_k127_1402567_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 470.0
TLS2_k127_1402567_1 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004745 340.0
TLS2_k127_1402567_2 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000105 280.0
TLS2_k127_1402567_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000008253 172.0
TLS2_k127_1402567_4 Double zinc ribbon - - - 0.00000000000000000000000000001703 125.0
TLS2_k127_1414420_0 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006446 356.0
TLS2_k127_1414420_1 NYN domain - - - 0.000000000000000000000000000000004347 147.0
TLS2_k127_1414420_2 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.0000000000000000000000001353 119.0
TLS2_k127_1414420_3 acylphosphatase activity K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.0000000000000004233 82.0
TLS2_k127_1414420_4 YtxH-like protein - - - 0.0009029 50.0
TLS2_k127_1436642_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 1.611e-212 679.0
TLS2_k127_1436642_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K03737 - 1.2.7.1 7.388e-203 647.0
TLS2_k127_1436642_10 cyclic nucleotide binding K10914 - - 0.0000000000000000009505 92.0
TLS2_k127_1436642_11 - - - - 0.000000004203 66.0
TLS2_k127_1436642_12 PFAM YbaK prolyl-tRNA synthetase associated region K19055 - - 0.000000008233 68.0
TLS2_k127_1436642_13 Hydrogenase maturation protease - - - 0.0001814 51.0
TLS2_k127_1436642_14 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.0003366 51.0
TLS2_k127_1436642_2 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 505.0
TLS2_k127_1436642_3 FAD-dependent pyridine nucleotide-disulfide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 439.0
TLS2_k127_1436642_4 PFAM Nickel-dependent hydrogenase, large subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006421 443.0
TLS2_k127_1436642_5 NADH ubiquinone oxidoreductase, 20 Kd subunit K14128 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 299.0
TLS2_k127_1436642_6 CoA binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000002994 216.0
TLS2_k127_1436642_7 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000002497 209.0
TLS2_k127_1436642_8 - - - - 0.000000000000000000000000000000000000000000000000000005028 211.0
TLS2_k127_1436642_9 PFAM CBS domain K07182 - - 0.00000000000000000001256 96.0
TLS2_k127_1472600_0 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 399.0
TLS2_k127_1472600_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 359.0
TLS2_k127_1472600_2 ATPases associated with a variety of cellular activities K02006,K02008,K16784,K16786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 315.0
TLS2_k127_1472600_3 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000003953 258.0
TLS2_k127_1472600_4 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008936 243.0
TLS2_k127_1472600_5 Activator of Hsp90 ATPase 1 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001076 241.0
TLS2_k127_1472600_6 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000001094 190.0
TLS2_k127_1472600_7 Bacterial-like globin - - - 0.000000000000000000000000000000771 126.0
TLS2_k127_1472600_8 Belongs to the Fur family K03711,K09825 - - 0.0000000000000000000000005201 119.0
TLS2_k127_1472600_9 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.000000000000004677 78.0
TLS2_k127_1485689_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 4.359e-209 699.0
TLS2_k127_1485689_1 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000787 418.0
TLS2_k127_1485689_2 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000002771 258.0
TLS2_k127_1485689_3 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000001791 143.0
TLS2_k127_1485689_4 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000006835 83.0
TLS2_k127_1485689_5 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000009954 82.0
TLS2_k127_1485689_6 Pilus assembly protein CpaB K02279 - - 0.00001683 57.0
TLS2_k127_152720_0 Amylo-alpha-1,6-glucosidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008349 426.0
TLS2_k127_152720_1 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007084 333.0
TLS2_k127_152720_2 binding-protein-dependent transport systems inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000001606 246.0
TLS2_k127_152720_3 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000005766 168.0
TLS2_k127_152720_4 ABC-2 type transporter - - - 0.00000000000000000000000000000000000004187 160.0
TLS2_k127_152720_5 Carbohydrate ABC transporter membrane protein 1, CUT1 family K02025 - - 0.000000000000000000000000000000000009939 139.0
TLS2_k127_152720_6 Psort location Cytoplasmic, score - - - 0.000000000000000000000000576 109.0
TLS2_k127_152720_7 Putative adhesin - - - 0.00000009883 64.0
TLS2_k127_1610702_0 ABC transporter K06147 - - 1.022e-239 762.0
TLS2_k127_1610702_1 Protein of unknown function, DUF255 K06888 - - 2.256e-197 638.0
TLS2_k127_1610702_10 GlcNAc-PI de-N-acetylase K22135 - - 0.0000000000000000000003259 104.0
TLS2_k127_1610702_11 Metal-sensitive transcriptional repressor K21600 - - 0.000000000000000003736 97.0
TLS2_k127_1610702_12 DNA methylAse K01155 - 3.1.21.4 0.00004633 57.0
TLS2_k127_1610702_2 Helix-hairpin-helix DNA-binding, class 1 K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007402 474.0
TLS2_k127_1610702_3 Aldehyde dehydrogenase K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007945 354.0
TLS2_k127_1610702_4 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 334.0
TLS2_k127_1610702_5 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005981 277.0
TLS2_k127_1610702_6 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000008237 234.0
TLS2_k127_1610702_7 Uncharacterised protein family UPF0047 - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000001429 192.0
TLS2_k127_1610702_8 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000000466 183.0
TLS2_k127_1610702_9 PFAM TPR repeat-containing protein - - - 0.00000000000000000000000000000000000001838 160.0
TLS2_k127_1625125_0 ATP dependent DNA ligase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 485.0
TLS2_k127_1625125_1 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005682 389.0
TLS2_k127_1625125_2 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 369.0
TLS2_k127_1625125_3 Bacterial periplasmic substrate-binding proteins K02030,K02424,K17073 - - 0.0000000000000000000000000000000000000000000000000000000000000001828 243.0
TLS2_k127_1625125_4 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000002968 212.0
TLS2_k127_1719867_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009119 593.0
TLS2_k127_1719867_1 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005061 447.0
TLS2_k127_1719867_3 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000003589 101.0
TLS2_k127_1719867_4 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000002321 95.0
TLS2_k127_1740015_0 Maltogenic Amylase, C-terminal domain K05343 - 3.2.1.1,5.4.99.16 1.076e-268 851.0
TLS2_k127_1740015_1 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 4.689e-194 627.0
TLS2_k127_1740015_2 PFAM Glucose Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 325.0
TLS2_k127_1740015_3 PFAM DNA repair protein RadC K03630 - - 0.00000000000000000000000000000000000000000000007042 177.0
TLS2_k127_1740015_4 CAAX amino terminal protease family K07052 - - 0.000000000000857 79.0
TLS2_k127_1759717_0 ATPases associated with a variety of cellular activities K09812 GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0008356,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0032506,GO:0042173,GO:0043937,GO:0043938,GO:0044085,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:1902531 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004641 269.0
TLS2_k127_1759717_1 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation K09811 - - 0.0000000000000000000000000000000000002858 151.0
TLS2_k127_1759717_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000001589 99.0
TLS2_k127_1759717_3 Belongs to the peptidase S41A family K03797 GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016787,GO:0019538,GO:0023052,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.102 0.00000000000000195 84.0
TLS2_k127_1759717_4 Acetyltransferase (GNAT) domain - - - 0.00000000000139 79.0
TLS2_k127_1762839_0 MFS transporter K11381 - 1.2.4.4 3.001e-219 703.0
TLS2_k127_1762839_1 3-methyladenine DNA glycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000171 266.0
TLS2_k127_1762839_10 Belongs to the class-I aminoacyl-tRNA synthetase family - - - 0.0001891 53.0
TLS2_k127_1762839_11 Protein of unknown function (DUF3352) - - - 0.0002352 55.0
TLS2_k127_1762839_2 Glycosyl transferases, related to UDP-glucuronosyltransferase - - - 0.000000000000000000000000000000000000000000000009123 190.0
TLS2_k127_1762839_3 Acyl-carrier-protein s-malonyltransferase - - - 0.000000000000000000000000000000000000000002584 171.0
TLS2_k127_1762839_4 EamA-like transporter family - - - 0.0000000000000000000000157 111.0
TLS2_k127_1762839_5 Cupin domain - - - 0.0000000000000001886 90.0
TLS2_k127_1762839_6 glycosyl transferase family 2 K20444 - - 0.00000000000001655 84.0
TLS2_k127_1762839_7 - - - - 0.00000002555 59.0
TLS2_k127_1762839_8 Helix-turn-helix domain - - - 0.0000001094 63.0
TLS2_k127_1762839_9 ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - 0.00007838 54.0
TLS2_k127_177009_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 1.902e-233 743.0
TLS2_k127_177009_1 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006578 475.0
TLS2_k127_177009_10 COG0346 Lactoylglutathione lyase and related lyases K05606 - 5.1.99.1 0.000000006939 58.0
TLS2_k127_177009_11 GDSL-like Lipase/Acylhydrolase family - - - 0.000000008897 66.0
TLS2_k127_177009_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004546 451.0
TLS2_k127_177009_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 401.0
TLS2_k127_177009_4 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 327.0
TLS2_k127_177009_5 Cyclic nucleotide-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 321.0
TLS2_k127_177009_6 Reverse transcriptase-like - - - 0.0000000000000000000000000000000003123 145.0
TLS2_k127_177009_7 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.000000000000000000000000003097 116.0
TLS2_k127_177009_8 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000000009095 108.0
TLS2_k127_177009_9 Copper binding proteins, plastocyanin/azurin family - - - 0.000000000000000001469 94.0
TLS2_k127_1802038_0 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 424.0
TLS2_k127_1802038_1 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 310.0
TLS2_k127_1802038_10 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 0.000000000000000002955 85.0
TLS2_k127_1802038_11 Transcriptional regulator, arsR family - - - 0.000000000000009174 78.0
TLS2_k127_1802038_2 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567,K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000001024 194.0
TLS2_k127_1802038_3 - - - - 0.0000000000000000000000000000000001611 136.0
TLS2_k127_1802038_4 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000003653 147.0
TLS2_k127_1802038_5 Belongs to the Nudix hydrolase family - - - 0.0000000000000000000000000000006076 127.0
TLS2_k127_1802038_6 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.000000000000000000000003252 115.0
TLS2_k127_1802038_7 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.000000000000000000000006017 107.0
TLS2_k127_1802038_8 Rhodanese Homology Domain - - - 0.00000000000000000000001036 113.0
TLS2_k127_1802038_9 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000006502 102.0
TLS2_k127_1837354_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 6.053e-248 787.0
TLS2_k127_1837354_1 TIGRFAM RNA polymerase sigma-54 factor, RpoN K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 364.0
TLS2_k127_1837354_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 GO:0006950,GO:0008150,GO:0050896,GO:0051409 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000003591 226.0
TLS2_k127_1837354_3 WD40-like Beta Propeller Repeat K03641 - - 0.0000000000000000001793 104.0
TLS2_k127_1837354_4 PFAM Phosphoglycerate mutase family K15634,K22306 - 3.1.3.85,5.4.2.12 0.000000000000000000449 94.0
TLS2_k127_1837354_5 Bacterial Ig-like domain - - - 0.000000001423 71.0
TLS2_k127_1875574_0 Glycosyl hydrolases family 15 K22308 - 3.2.1.205 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 321.0
TLS2_k127_1875574_1 endonuclease III K01247 - 3.2.2.21 0.00000000000000000000000000000000000000007624 158.0
TLS2_k127_1875574_2 Domain of unknown function (DUF1918) - - - 0.00004407 50.0
TLS2_k127_1891757_0 Maltose acetyltransferase K00661 - 2.3.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000001588 256.0
TLS2_k127_1891757_1 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.0000000000000000000000000000000000000000000000000000006825 203.0
TLS2_k127_1891757_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.00000000000000000000000000000000000000000000000002513 183.0
TLS2_k127_1891757_3 Belongs to the UPF0173 family - - - 0.000000000000000000000000000000000000000000000002033 186.0
TLS2_k127_1891757_4 Metallo-beta-lactamase domain protein K01069 - 3.1.2.6 0.00000000000000000000000000000000003656 149.0
TLS2_k127_1953978_0 Histidine Phosphotransfer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006319 558.0
TLS2_k127_1953978_1 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 392.0
TLS2_k127_1953978_2 Glycosyl hydrolase family 26 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 373.0
TLS2_k127_1953978_3 3-oxo-5-alpha-steroid 4-dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004762 258.0
TLS2_k127_1953978_4 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000001739 198.0
TLS2_k127_1953978_5 Histidine phosphatase superfamily (branch 1) K01834 - 5.4.2.11 0.00000000000000000000000000000007192 132.0
TLS2_k127_1953978_6 Histidine Phosphotransfer domain - - - 0.0000000003245 65.0
TLS2_k127_1953978_7 Protein of unknown function (DUF1440) K08996 - - 0.0000000005616 67.0
TLS2_k127_199299_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835,K01840 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 459.0
TLS2_k127_199299_1 Bacterial phospho-glucose isomerase C-terminal SIS domain K15916 - 5.3.1.8,5.3.1.9 0.000000000000000000000000000000000000000001754 176.0
TLS2_k127_199299_2 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000146 141.0
TLS2_k127_199299_3 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000001104 109.0
TLS2_k127_2061870_0 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003922 273.0
TLS2_k127_2061870_1 Metallopeptidase family M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003566 243.0
TLS2_k127_2061870_2 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000009398 230.0
TLS2_k127_2061870_3 Cro/C1-type HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000008477 187.0
TLS2_k127_2115771_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000603 489.0
TLS2_k127_2115771_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 350.0
TLS2_k127_2115771_2 Belongs to the FPG family K05522 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000007454 256.0
TLS2_k127_2115771_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000000000000000000000000009863 131.0
TLS2_k127_2140205_0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K13075 - 3.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 361.0
TLS2_k127_2140205_1 lactoylglutathione lyase activity K01239 - 3.2.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000002058 256.0
TLS2_k127_2140205_2 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000001283 184.0
TLS2_k127_2140205_3 Nucleoside 2-deoxyribosyltransferase - - - 0.0000000000000000000000000000002587 127.0
TLS2_k127_2140205_4 S4 RNA-binding domain K04762 - - 0.000000000000000000000000000004389 133.0
TLS2_k127_2140205_5 NmrA-like family - - - 0.00000000000000000000004619 108.0
TLS2_k127_2143052_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 462.0
TLS2_k127_2143052_1 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000003295 258.0
TLS2_k127_2143052_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000006566 157.0
TLS2_k127_2143052_3 Universal stress protein family - - - 0.0000000000000244 78.0
TLS2_k127_2143052_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.000000002863 61.0
TLS2_k127_2168087_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 8.27e-261 814.0
TLS2_k127_2168087_1 L-lactate permease K03303 - - 6.097e-225 709.0
TLS2_k127_2168087_10 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000377 171.0
TLS2_k127_2168087_11 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000002085 167.0
TLS2_k127_2168087_12 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000002748 164.0
TLS2_k127_2168087_13 Regulates arginine biosynthesis genes K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000003062 115.0
TLS2_k127_2168087_14 conserved protein, contains double-stranded beta-helix domain - - - 0.00000000000000000000006548 99.0
TLS2_k127_2168087_15 AI-2E family transporter - - - 0.0000000000000000001431 101.0
TLS2_k127_2168087_16 - - - - 0.00000000000000001234 92.0
TLS2_k127_2168087_17 - - - - 0.000000003227 66.0
TLS2_k127_2168087_18 metal-dependent hydrolase with the TIM-barrel fold K07048 - - 0.000000008631 57.0
TLS2_k127_2168087_19 - - - - 0.00007002 48.0
TLS2_k127_2168087_2 L-lactate permease K03303 - - 9.632e-194 620.0
TLS2_k127_2168087_3 Sulfurtransferase K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006038 503.0
TLS2_k127_2168087_4 ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 473.0
TLS2_k127_2168087_5 Aminotransferase class-III K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 366.0
TLS2_k127_2168087_6 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006989 344.0
TLS2_k127_2168087_7 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007483 291.0
TLS2_k127_2168087_8 BioY family K03523 - - 0.00000000000000000000000000000000000000000000000000000000000001399 220.0
TLS2_k127_2168087_9 SufE protein probably involved in Fe-S center assembly K02426 - - 0.000000000000000000000000000000000000000000000001952 184.0
TLS2_k127_2172879_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 316.0
TLS2_k127_2172879_1 Glycosyl transferase 4-like domain K08256 - 2.4.1.345 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009683 323.0
TLS2_k127_2172879_10 - - - - 0.0000004505 60.0
TLS2_k127_2172879_2 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005025 275.0
TLS2_k127_2172879_3 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000007258 224.0
TLS2_k127_2172879_4 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000007859 201.0
TLS2_k127_2172879_5 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000000000000000000000000000000007061 176.0
TLS2_k127_2172879_6 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000000000000001976 179.0
TLS2_k127_2172879_7 Phage shock protein C (PspC) K03973 - - 0.000000000000000000007827 99.0
TLS2_k127_2172879_8 lipid A biosynthesis acyltransferase K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.00000000000003687 78.0
TLS2_k127_2172879_9 membrane - - - 0.0000000000002822 82.0
TLS2_k127_2229102_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 1.552e-206 668.0
TLS2_k127_2229102_1 TIGRFAM riboflavin biosynthesis protein RibF K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000007507 218.0
TLS2_k127_2229102_2 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000009122 126.0
TLS2_k127_2239004_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006459 546.0
TLS2_k127_2239004_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 453.0
TLS2_k127_2239004_10 TRANSCRIPTIONal - - - 0.00000000000000000000000000000000000000001401 177.0
TLS2_k127_2239004_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000000000000000000000000001227 139.0
TLS2_k127_2239004_12 NUDIX domain - - - 0.000000000003067 74.0
TLS2_k127_2239004_13 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000001519 74.0
TLS2_k127_2239004_14 May be required for sporulation K09762 - - 0.00003118 55.0
TLS2_k127_2239004_2 Required for morphogenesis under gluconeogenic growth conditions - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 378.0
TLS2_k127_2239004_3 PFAM phosphoesterase, RecJ domain protein K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000519 318.0
TLS2_k127_2239004_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K01919,K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000114 295.0
TLS2_k127_2239004_5 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000002131 248.0
TLS2_k127_2239004_6 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000004939 235.0
TLS2_k127_2239004_7 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000001043 222.0
TLS2_k127_2239004_8 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000001469 205.0
TLS2_k127_2239004_9 DNA helicase K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000005004 201.0
TLS2_k127_2275037_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 1.387e-203 642.0
TLS2_k127_2275037_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 539.0
TLS2_k127_2275037_10 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000004342 58.0
TLS2_k127_2275037_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000008931 196.0
TLS2_k127_2275037_3 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000225 139.0
TLS2_k127_2275037_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109,K02113 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000006646 125.0
TLS2_k127_2275037_5 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000002451 113.0
TLS2_k127_2275037_6 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000001005 107.0
TLS2_k127_2275037_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000001642 85.0
TLS2_k127_2275037_9 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.0000001793 57.0
TLS2_k127_2351619_0 Belongs to the thiolase family K00626,K02615 - 2.3.1.174,2.3.1.223,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009682 528.0
TLS2_k127_2351619_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 321.0
TLS2_k127_2351619_2 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000007271 225.0
TLS2_k127_2351619_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000004254 196.0
TLS2_k127_2351619_4 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000006709 179.0
TLS2_k127_2351619_5 response to pH - - - 0.000000000000000000000000000000000000000009103 162.0
TLS2_k127_2351619_6 PFAM Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000002917 133.0
TLS2_k127_2351619_7 2'-5' RNA ligase superfamily - - - 0.0000000000000000000000000009425 130.0
TLS2_k127_2351619_8 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000008707 82.0
TLS2_k127_238370_0 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 417.0
TLS2_k127_238370_1 fructose-bisphosphate aldolase activity K01624 - 4.1.2.13 0.000000000000000000000000000000001216 134.0
TLS2_k127_238370_2 Belongs to the HesB IscA family K13628,K15724 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564 - 0.0000000000000000000000000000000124 138.0
TLS2_k127_238370_3 Belongs to the GbsR family - - - 0.00000000000602 78.0
TLS2_k127_2435214_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 375.0
TLS2_k127_2435214_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009854 340.0
TLS2_k127_2449141_0 Aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 595.0
TLS2_k127_2449141_1 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004164 391.0
TLS2_k127_2449141_10 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000009511 89.0
TLS2_k127_2449141_11 PFAM pfkB family carbohydrate kinase - - - 0.000000000000004485 86.0
TLS2_k127_2449141_12 Uncharacterized protein conserved in bacteria (DUF2087) - - - 0.0000000000001373 74.0
TLS2_k127_2449141_13 - - - - 0.000000000002221 76.0
TLS2_k127_2449141_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006081 354.0
TLS2_k127_2449141_3 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004938 282.0
TLS2_k127_2449141_4 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007194 277.0
TLS2_k127_2449141_5 adenylate kinase activity K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000001146 190.0
TLS2_k127_2449141_6 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K21142 - 2.8.1.12 0.0000000000000000000000000000000000000003339 157.0
TLS2_k127_2449141_7 UbiA prenyltransferase family - - - 0.00000000000000000007661 102.0
TLS2_k127_2449141_8 Uncharacterized conserved protein (DUF2203) - - - 0.00000000000000001616 85.0
TLS2_k127_2449141_9 PFAM Rieske 2Fe-2S K05710 - - 0.0000000000000006815 87.0
TLS2_k127_2452360_0 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000000000000000000000000000000000000000000000000000000000001468 213.0
TLS2_k127_2452360_1 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000001527 218.0
TLS2_k127_2480908_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 497.0
TLS2_k127_2480908_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 321.0
TLS2_k127_2480908_10 Domain present in PSD-95, Dlg, and ZO-1/2. K11749 - - 0.0000000000000000000000000000000000000000000000000000968 201.0
TLS2_k127_2480908_11 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000000000000244 179.0
TLS2_k127_2480908_12 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000001515 155.0
TLS2_k127_2480908_13 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000145 134.0
TLS2_k127_2480908_14 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - 0.0000000000000000000006957 102.0
TLS2_k127_2480908_15 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000001201 98.0
TLS2_k127_2480908_16 KH domain K06960 - - 0.000000000000000003072 87.0
TLS2_k127_2480908_17 Belongs to the UPF0102 family K07460 - - 0.00000000007369 71.0
TLS2_k127_2480908_18 Protein of unknown function (DUF3352) - - - 0.00000002568 66.0
TLS2_k127_2480908_2 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003077 331.0
TLS2_k127_2480908_3 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 311.0
TLS2_k127_2480908_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007997 282.0
TLS2_k127_2480908_5 Belongs to the RNA methyltransferase TrmD family K00554,K01770 GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003023 280.0
TLS2_k127_2480908_6 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000001335 242.0
TLS2_k127_2480908_7 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000001286 239.0
TLS2_k127_2480908_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000002196 220.0
TLS2_k127_2480908_9 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000326 205.0
TLS2_k127_2484023_0 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006242 517.0
TLS2_k127_2484023_1 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005171 302.0
TLS2_k127_2484023_2 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001811 279.0
TLS2_k127_2484023_3 Fumarylacetoacetate (FAA) hydrolase family K16171 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000001613 276.0
TLS2_k127_2484023_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000003951 192.0
TLS2_k127_2484023_5 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000006773 184.0
TLS2_k127_2484023_6 domain protein - - - 0.000000000000000000000003377 110.0
TLS2_k127_2484023_7 cheY-homologous receiver domain - - - 0.0000000000000000000002989 101.0
TLS2_k127_2484023_8 DinB family - - - 0.00000002089 67.0
TLS2_k127_249232_0 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006372 361.0
TLS2_k127_249232_1 COG3221 ABC-type phosphate phosphonate transport system, periplasmic component K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001136 271.0
TLS2_k127_249232_2 Binding-protein-dependent transport system inner membrane component K02042 - - 0.0000000000000000000000000000000000000000000000000000000000001186 230.0
TLS2_k127_249232_3 ABC-type phosphate phosphonate transport system permease component K02042 - - 0.000000000000000000000000000000000000000000000005047 185.0
TLS2_k127_249232_4 VIT family - - - 0.00000000000000000000000000000000000000000000001545 186.0
TLS2_k127_2763588_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006242 563.0
TLS2_k127_2763588_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000411 341.0
TLS2_k127_2763588_2 Belongs to the peptidase M16 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 297.0
TLS2_k127_2763588_3 DRTGG domain K06873 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006562 276.0
TLS2_k127_2763588_4 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000007653 246.0
TLS2_k127_2763588_5 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000001036 237.0
TLS2_k127_2763588_6 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.000000003829 61.0
TLS2_k127_2763588_7 - - - - 0.0001502 51.0
TLS2_k127_27867_0 Fumarase C C-terminus K01679 GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 2.385e-226 714.0
TLS2_k127_27867_1 Belongs to the aldehyde dehydrogenase family K22187 - - 3.476e-199 632.0
TLS2_k127_27867_10 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000002298 64.0
TLS2_k127_27867_2 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003812 582.0
TLS2_k127_27867_3 Alpha amylase catalytic K01187,K05343 - 3.2.1.1,3.2.1.20,5.4.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 540.0
TLS2_k127_27867_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00596,K00823 - 2.6.1.19,4.1.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009974 486.0
TLS2_k127_27867_5 PFAM regulatory protein LuxR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000438 434.0
TLS2_k127_27867_6 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000008199 272.0
TLS2_k127_27867_7 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000314 229.0
TLS2_k127_27867_8 ATP-dependent protease La (LON) substrate-binding domain K01338,K07157 - 3.4.21.53 0.00000000000000000000000000000000004335 147.0
TLS2_k127_27867_9 Domain of unknown function (DUF309) K09763 - - 0.0000000000000004097 90.0
TLS2_k127_2873384_0 Malate synthase K01638 - 2.3.3.9 5.06e-211 668.0
TLS2_k127_2873384_1 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 363.0
TLS2_k127_2873384_10 response to heat K03668,K09914 - - 0.000000000000000000000000000000000002252 154.0
TLS2_k127_2873384_11 peptide catabolic process - - - 0.00000000000000000000000000000000444 147.0
TLS2_k127_2873384_12 Probable zinc-ribbon domain - - - 0.000000000000000000000000000001818 125.0
TLS2_k127_2873384_13 hydroxyisourate hydrolase activity K07127,K13485 GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009112,GO:0009987,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564 3.5.2.17,4.1.1.97 0.000000000000000000000004776 106.0
TLS2_k127_2873384_15 acetyltransferase K03825 - - 0.0000008636 54.0
TLS2_k127_2873384_2 Amidohydrolase family K01464 - 3.5.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 338.0
TLS2_k127_2873384_4 xanthine dehydrogenase activity K13479 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000001212 218.0
TLS2_k127_2873384_5 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000171 191.0
TLS2_k127_2873384_6 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000000000000000000000000000000077 187.0
TLS2_k127_2873384_7 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000008252 183.0
TLS2_k127_2873384_8 Protein of unknown function (DUF3830) - - - 0.000000000000000000000000000000000000000000654 168.0
TLS2_k127_2873384_9 DNA binding - - - 0.000000000000000000000000000000000000000002122 167.0
TLS2_k127_2939075_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 525.0
TLS2_k127_2939075_1 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 431.0
TLS2_k127_2939075_10 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000008811 188.0
TLS2_k127_2939075_11 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000001501 141.0
TLS2_k127_2939075_12 RES - - - 0.00000000000000000000000000000001544 137.0
TLS2_k127_2939075_13 Belongs to the thioredoxin family K03671 - - 0.00000000000000000000000000009727 128.0
TLS2_k127_2939075_14 YCII-related domain - - - 0.000000000000000000000008611 105.0
TLS2_k127_2939075_16 sequence-specific DNA binding - - - 0.00000000000000000000259 97.0
TLS2_k127_2939075_17 Pyruvate:ferredoxin oxidoreductase core domain II K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000005159 96.0
TLS2_k127_2939075_18 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000000000000000007532 103.0
TLS2_k127_2939075_19 PFAM Sporulation and spore germination - - - 0.00000000000000008209 89.0
TLS2_k127_2939075_2 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 372.0
TLS2_k127_2939075_20 CGNR zinc finger - - - 0.00000000000003709 79.0
TLS2_k127_2939075_21 Transcriptional K03892 - - 0.0000000000006572 82.0
TLS2_k127_2939075_22 PFAM 4Fe-4S K00176 - 1.2.7.3 0.0000000007506 65.0
TLS2_k127_2939075_23 - K22014 - - 0.000000001422 62.0
TLS2_k127_2939075_3 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005882 345.0
TLS2_k127_2939075_4 40-residue YVTN family beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 304.0
TLS2_k127_2939075_5 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001034 301.0
TLS2_k127_2939075_6 40-residue YVTN family beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001469 285.0
TLS2_k127_2939075_7 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000002986 275.0
TLS2_k127_2939075_8 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000003247 244.0
TLS2_k127_2939075_9 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000009615 228.0
TLS2_k127_2947735_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 468.0
TLS2_k127_2947735_1 AAA domain, putative AbiEii toxin, Type IV TA system K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007835 442.0
TLS2_k127_2947735_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000004414 250.0
TLS2_k127_2947735_3 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000768 237.0
TLS2_k127_2947735_4 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000009313 229.0
TLS2_k127_2979642_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 588.0
TLS2_k127_2979642_1 4-Hydroxyphenylpyruvate dioxygenase K00457,K16421 GO:0003674,GO:0003824,GO:0003868,GO:0006082,GO:0006520,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0051213,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.27,1.13.11.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008994 509.0
TLS2_k127_2979642_10 Domain of unknown function (DUF4440) - - - 0.000000000000000000006974 96.0
TLS2_k127_2979642_11 Major Facilitator Superfamily - - - 0.0000000000078 77.0
TLS2_k127_2979642_2 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 327.0
TLS2_k127_2979642_3 Acetyltransferases including N-acetylases of ribosomal proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002809 252.0
TLS2_k127_2979642_4 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009821 250.0
TLS2_k127_2979642_5 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000007001 248.0
TLS2_k127_2979642_6 Protein of unknown function (DUF421) - - - 0.0000000000000000000000000000000000000000000000000000000000000177 219.0
TLS2_k127_2979642_7 Phosphorylase superfamily K00772,K03784 - 2.4.2.1,2.4.2.28 0.000000000000000000000000000000000000000000000000000000000003755 222.0
TLS2_k127_2979642_8 Inositol monophosphatase K01092 GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 0.0000000000000000000000000000000000000000001995 169.0
TLS2_k127_2979642_9 - - - - 0.000000000000000000000000000002058 129.0
TLS2_k127_2986902_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 1.834e-281 908.0
TLS2_k127_2986902_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 573.0
TLS2_k127_2986902_10 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000007901 231.0
TLS2_k127_2986902_11 helix_turn_helix, Lux Regulon K11618 - - 0.0000000000000000000000000000000000000000000000000000000008409 217.0
TLS2_k127_2986902_12 histidine kinase, dimerisation and phosphoacceptor region - - - 0.0000000000000000000000000000000000000000000000000000002694 224.0
TLS2_k127_2986902_13 Protein of unknown function (DUF421) - - - 0.00000000000000000000000000000000000000000000000000001714 202.0
TLS2_k127_2986902_14 Carboxyltransferase domain, subdomain A and B - - - 0.00000000000000000000000000000000000000000000000000001882 209.0
TLS2_k127_2986902_15 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.00000000000000000000000000000000000000000000000002335 190.0
TLS2_k127_2986902_16 ACT domain K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000008411 192.0
TLS2_k127_2986902_17 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000004599 182.0
TLS2_k127_2986902_18 Allophanate hydrolase subunit 2 - - - 0.00000000000000000000000000000000000000000003917 176.0
TLS2_k127_2986902_19 signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000001539 181.0
TLS2_k127_2986902_2 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 559.0
TLS2_k127_2986902_20 phosphatase activity K07025 - - 0.000000000000000000000000000000000000000601 169.0
TLS2_k127_2986902_21 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000001468 159.0
TLS2_k127_2986902_22 Ion transport protein K10716 - - 0.0000000000000000000000000000000356 134.0
TLS2_k127_2986902_23 PFAM response regulator receiver - - - 0.000000000000000000000002026 106.0
TLS2_k127_2986902_24 PFAM pyridoxamine 5'-phosphate oxidase-related - - - 0.00000000000000000000000893 109.0
TLS2_k127_2986902_25 - - - - 0.000000000000000000005597 106.0
TLS2_k127_2986902_26 - - - - 0.00000000000000000516 97.0
TLS2_k127_2986902_27 EamA-like transporter family - - - 0.00000000000001174 85.0
TLS2_k127_2986902_28 UPF0761 membrane protein K07058 - - 0.00000000005476 74.0
TLS2_k127_2986902_29 PFAM blue (type 1) copper domain protein - - - 0.0000000003015 74.0
TLS2_k127_2986902_3 ABC transporter K06158 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000673 562.0
TLS2_k127_2986902_30 response regulator, receiver K07684 - - 0.0000004804 57.0
TLS2_k127_2986902_31 Alkyl hydroperoxide reductase K03564 - 1.11.1.15 0.000002414 60.0
TLS2_k127_2986902_32 - - - - 0.000004607 55.0
TLS2_k127_2986902_34 - - - - 0.00005745 53.0
TLS2_k127_2986902_35 HesB YadR YfhF-family protein - - - 0.0003843 49.0
TLS2_k127_2986902_4 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004771 474.0
TLS2_k127_2986902_5 Divalent cation transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004065 451.0
TLS2_k127_2986902_6 Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002787 273.0
TLS2_k127_2986902_7 Belongs to the UPF0271 (lamB) family K07160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004361 285.0
TLS2_k127_2986902_8 Zinc-binding dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000004882 242.0
TLS2_k127_2986902_9 endonuclease III K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000001108 238.0
TLS2_k127_3020451_0 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 302.0
TLS2_k127_3020451_1 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001163 275.0
TLS2_k127_3020451_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.0000000000000000000000000000000000002654 145.0
TLS2_k127_3020451_3 G5 K21688 GO:0005575,GO:0005576,GO:0008150,GO:0009892,GO:0009893,GO:0010468,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019222,GO:0022611,GO:0032502,GO:0040008,GO:0040009,GO:0040010,GO:0044111,GO:0044114,GO:0044115,GO:0044403,GO:0044419,GO:0045927,GO:0048518,GO:0048519,GO:0050789,GO:0051704,GO:0060255,GO:0065007,GO:0085016 - 0.000000000000000000000000000000001612 136.0
TLS2_k127_3020451_4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768 - 5.2.1.8 0.000000000000000000000000006086 126.0
TLS2_k127_3020451_5 alpha beta K06889 - - 0.000000000000000000001214 111.0
TLS2_k127_3020451_6 - - - - 0.00000000000008524 84.0
TLS2_k127_3020451_7 Anti-sigma-K factor rskA - - - 0.00001841 53.0
TLS2_k127_3025836_0 Domain of unknown function (DUF3459) K01187 - 3.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 545.0
TLS2_k127_3025836_1 ABC transporter substrate-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001131 292.0
TLS2_k127_3025836_2 Glycosyl transferase, group 1 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002509 258.0
TLS2_k127_312643_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 606.0
TLS2_k127_312643_1 PFAM Glycosyl transferase family 2 K00694 - 2.4.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 512.0
TLS2_k127_312643_10 Uncharacterized protein conserved in bacteria (DUF2255) - - - 0.0000002885 58.0
TLS2_k127_312643_2 PFAM oxidoreductase molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 463.0
TLS2_k127_312643_3 Beta-eliminating lyase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 391.0
TLS2_k127_312643_4 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.0000000000000000000000000000000000000000000000000000000000000002386 234.0
TLS2_k127_312643_5 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000002132 188.0
TLS2_k127_312643_6 Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000000000000000000000000000002493 181.0
TLS2_k127_312643_7 lipolytic protein G-D-S-L family - - - 0.000000000000000000000006328 112.0
TLS2_k127_312643_8 TIGRFAM phenylacetate-CoA oxygenase, PaaG subunit K02609 - 1.14.13.149 0.0000000000000000000002634 99.0
TLS2_k127_312643_9 Periplasmic component of the Tol biopolymer transport system - - - 0.000000001134 70.0
TLS2_k127_3144308_0 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 388.0
TLS2_k127_3144308_1 Heavy-metal-associated domain K17686 - 3.6.3.54 0.0000000000000000000000000000000003296 133.0
TLS2_k127_3144308_2 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000000000000000000000003284 111.0
TLS2_k127_3144308_3 monooxygenase activity - - - 0.00000000001631 66.0
TLS2_k127_3156273_0 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 299.0
TLS2_k127_3156273_1 - - - - 0.0000000000000000000000000000000000000000000001538 179.0
TLS2_k127_3156273_2 COG1668 ABC-type Na efflux pump, permease component - - - 0.0000000000000000000000000000000003153 145.0
TLS2_k127_3156273_3 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000001053 86.0
TLS2_k127_3156273_4 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003,K05685 - - 0.000000000000001992 79.0
TLS2_k127_3156273_5 Alpha mannosidase, middle domain K01191,K15524 - 3.2.1.170,3.2.1.24 0.000000000005175 69.0
TLS2_k127_3160589_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 493.0
TLS2_k127_3160589_1 tRNA pseudouridylate synthase B C-terminal domain K03177 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.00000000000000000000000000000000000000000000000000006053 199.0
TLS2_k127_3160589_2 DHH family K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000001082 184.0
TLS2_k127_3160589_3 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000001574 111.0
TLS2_k127_3222643_0 ATPase with chaperone activity K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007569 374.0
TLS2_k127_3222643_1 PFAM band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008729 318.0
TLS2_k127_3222643_2 PFAM response regulator receiver K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000004951 251.0
TLS2_k127_3222643_3 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000004525 215.0
TLS2_k127_3222643_4 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000000000000000000000000000000003062 147.0
TLS2_k127_3231214_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 7.713e-263 841.0
TLS2_k127_3231214_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 332.0
TLS2_k127_3231214_2 DNA recombination-mediator protein A K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000001628 248.0
TLS2_k127_3231214_3 Tyrosine recombinase XerD K04763 GO:0008150,GO:0040007 - 0.000000000000000000000000000000000000000000000000000000000009338 229.0
TLS2_k127_3231214_4 Methicillin resistance protein K05363,K18354 - 2.3.2.10 0.000000000000000000000000000000007858 139.0
TLS2_k127_3231214_5 Mg chelatase subunit ChlI K07391 - - 0.00000000000002 76.0
TLS2_k127_3231214_6 Cysteine-rich secretory protein family - - - 0.000000002837 70.0
TLS2_k127_3278601_0 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 364.0
TLS2_k127_3278601_1 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000001122 262.0
TLS2_k127_3278601_2 - - - - 0.00000000000000000000000000000001474 142.0
TLS2_k127_3278601_3 Protein of unknown function (DUF3303) - - - 0.00000000000000000000000000000006293 126.0
TLS2_k127_3278601_4 repeat protein - - - 0.00000000000000001094 83.0
TLS2_k127_3289537_0 NTF2-like N-terminal transpeptidase domain K05515 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000002604 259.0
TLS2_k127_3289537_1 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000007594 218.0
TLS2_k127_3289537_2 AAA domain - - - 0.0000000000000000000000000000000000000002195 157.0
TLS2_k127_3334149_0 R3H domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 595.0
TLS2_k127_3334149_1 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity K06215 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005039 387.0
TLS2_k127_3334149_2 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000348 219.0
TLS2_k127_3334149_3 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000006423 204.0
TLS2_k127_3334149_4 PFAM peptidase M15B and M15C DD-carboxypeptidase VanY K07260 - 3.4.17.14 0.0000000000000000000000000000000000007104 157.0
TLS2_k127_3334149_5 Cyclic-di-AMP receptor - - - 0.0000000000000000000000000000000001664 139.0
TLS2_k127_3334149_6 Metallo-beta-lactamase superfamily - - - 0.00000000000000004116 95.0
TLS2_k127_3334149_7 - - - - 0.0001296 54.0
TLS2_k127_3334149_8 GTP binding - - - 0.0002463 52.0
TLS2_k127_3334149_9 DinB superfamily - - - 0.0008709 49.0
TLS2_k127_3370990_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 520.0
TLS2_k127_3370990_1 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 434.0
TLS2_k127_3370990_2 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000462 430.0
TLS2_k127_3370990_3 Electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000000000000000000002792 198.0
TLS2_k127_3370990_4 AsnC family K03718 - - 0.000000000000000000000000000000000000000000000004068 177.0
TLS2_k127_3370990_5 Membrane - - - 0.0000000000000000000000000000000000000000000000254 181.0
TLS2_k127_3370990_6 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000001188 172.0
TLS2_k127_3478237_0 Participates in initiation and elongation during chromosome replication K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003864 482.0
TLS2_k127_3478237_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 455.0
TLS2_k127_3478237_10 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000002578 210.0
TLS2_k127_3478237_11 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000001488 194.0
TLS2_k127_3478237_12 NMT1/THI5 like K02051 - - 0.000000000000000000000000000000000000000000000000189 198.0
TLS2_k127_3478237_13 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.000000000000000000000000000000000000000000000002095 184.0
TLS2_k127_3478237_14 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000006685 179.0
TLS2_k127_3478237_15 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000000003226 135.0
TLS2_k127_3478237_16 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000004927 125.0
TLS2_k127_3478237_17 Acetyltransferase (GNAT) domain K00657,K00663 - 2.3.1.57,2.3.1.82 0.00000000000000000000000000004548 128.0
TLS2_k127_3478237_18 Formiminotransferase-cyclodeaminase K00603,K13990 - 2.1.2.5,4.3.1.4 0.0000000000000000000000008204 113.0
TLS2_k127_3478237_19 SnoaL-like domain - - - 0.00000000000000000002506 98.0
TLS2_k127_3478237_2 IMP dehydrogenase GMP reductase K00088 - 1.1.1.205 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005575 399.0
TLS2_k127_3478237_20 Phosphoesterase, PA-phosphatase related K19302 - 3.6.1.27 0.000000000004777 76.0
TLS2_k127_3478237_21 Protein of unknown function (DUF1232) - - - 0.00000000001468 72.0
TLS2_k127_3478237_3 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 384.0
TLS2_k127_3478237_4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K14161 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 361.0
TLS2_k127_3478237_5 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 356.0
TLS2_k127_3478237_6 Aromatic amino acid lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000303 249.0
TLS2_k127_3478237_7 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002508 242.0
TLS2_k127_3478237_8 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000002666 237.0
TLS2_k127_3478237_9 Binding-protein-dependent transport system inner membrane component K02050 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000007975 218.0
TLS2_k127_3491150_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 5.382e-237 760.0
TLS2_k127_3491150_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005847 562.0
TLS2_k127_3491150_10 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - 0.000000000000000000005454 103.0
TLS2_k127_3491150_11 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000002324 62.0
TLS2_k127_3491150_12 Uncharacterised protein family (UPF0180) - - - 0.000008844 51.0
TLS2_k127_3491150_2 cell division - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 330.0
TLS2_k127_3491150_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003646 327.0
TLS2_k127_3491150_4 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 315.0
TLS2_k127_3491150_5 Xaa-Pro dipeptidase K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000926 274.0
TLS2_k127_3491150_6 Anabaena sensory rhodopsin transducer - - - 0.00000000000000000000000000000000000000000000000000000000003225 207.0
TLS2_k127_3491150_7 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000863 216.0
TLS2_k127_3491150_8 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000662 149.0
TLS2_k127_3491150_9 PFAM FAD linked oxidase domain protein - - - 0.00000000000000000000000000003511 122.0
TLS2_k127_3581055_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 637.0
TLS2_k127_3581055_1 TIGRFAM cysteine desulfurase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004876 433.0
TLS2_k127_3581055_2 DNA primase, small subunit K01971 - 6.5.1.1 0.00000000000000000000000000000000000000002941 154.0
TLS2_k127_3581055_3 SMART Peptidoglycan-binding LysM - - - 0.0000000000000000000000000002381 131.0
TLS2_k127_3581055_4 ribonuclease BN K07058 - - 0.000000000000000000000001677 115.0
TLS2_k127_359071_0 COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 5.245e-239 765.0
TLS2_k127_359071_1 Biotin carboxylase, N-terminal domain K01968,K13777 - 6.4.1.4,6.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003757 523.0
TLS2_k127_359071_10 PFAM Inosine uridine-preferring nucleoside hydrolase K01239 - 3.2.2.1 0.000000000000000000000000000000000000000000000000004816 195.0
TLS2_k127_359071_11 Psort location CytoplasmicMembrane, score K02006,K16786,K16787 - - 0.000000000000000000000000000000000000000000000000005892 201.0
TLS2_k127_359071_12 Cobalt transport protein K02008,K16785 - - 0.0000000000000000000000000000000000000000000005144 176.0
TLS2_k127_359071_13 Domain of unknown function (DUF4397) - - - 0.0000000000000000000000000000000000000000000005886 178.0
TLS2_k127_359071_14 phosphorelay sensor kinase activity K16923,K18967 - 2.7.7.65 0.00000000000000000000000000000000000000000001013 176.0
TLS2_k127_359071_15 adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000003334 149.0
TLS2_k127_359071_16 Putative tRNA binding domain K06878 GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000002053 132.0
TLS2_k127_359071_17 PFAM NUDIX hydrolase - - - 0.0000000000000000000000000000818 122.0
TLS2_k127_359071_18 diguanylate cyclase - - - 0.0000000000000000000000002552 122.0
TLS2_k127_359071_19 GlcNAc-PI de-N-acetylase K22135 - - 0.0000000000000000000000124 112.0
TLS2_k127_359071_2 LD-carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 484.0
TLS2_k127_359071_20 Glyoxalase-like domain - - - 0.000000000001261 81.0
TLS2_k127_359071_21 Pfam:DUF59 - - - 0.0000000004439 66.0
TLS2_k127_359071_3 Cation transport protein K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 410.0
TLS2_k127_359071_4 PFAM pyruvate carboxyltransferase K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000974 342.0
TLS2_k127_359071_5 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007964 324.0
TLS2_k127_359071_6 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000006241 246.0
TLS2_k127_359071_7 TrkA-C domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000001335 239.0
TLS2_k127_359071_8 ATPases associated with a variety of cellular activities K16786,K16787 - - 0.0000000000000000000000000000000000000000000000000000000000000137 236.0
TLS2_k127_359071_9 Enoyl-CoA hydratase/isomerase K13766,K13779 - 4.2.1.18,4.2.1.57 0.0000000000000000000000000000000000000000000000000000000000001499 232.0
TLS2_k127_3626812_0 PFAM O-methyltransferase, family 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003858 261.0
TLS2_k127_3626812_1 N-acetylglucosaminylinositol deacetylase activity K18455 - 3.5.1.115 0.00000000000000000000000000000000000000000000000000000002872 209.0
TLS2_k127_3626812_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000002748 174.0
TLS2_k127_3626812_3 protein conserved in bacteria containing thioredoxin-like domain - - - 0.00000000000000000000000000000000000000000005537 171.0
TLS2_k127_3626812_4 Patatin-like phospholipase K07001 - - 0.000000000000005238 84.0
TLS2_k127_3628641_0 Aldehyde dehydrogenase family K04072,K13922 - 1.1.1.1,1.2.1.10,1.2.1.87 2.765e-201 636.0
TLS2_k127_3628641_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 2.342e-194 646.0
TLS2_k127_3628641_10 Oxidoreductase family, C-terminal alpha/beta domain K00010 - 1.1.1.18,1.1.1.369 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000419 355.0
TLS2_k127_3628641_11 Alcohol dehydrogenase GroES-like domain K00001,K00008 - 1.1.1.1,1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005834 285.0
TLS2_k127_3628641_13 Bacterial transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000002957 202.0
TLS2_k127_3628641_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000007244 196.0
TLS2_k127_3628641_15 Bacterial transcriptional regulator - - - 0.0000000000000000000000000000000000000001965 168.0
TLS2_k127_3628641_16 Cupin - - - 0.00000000000000000000000000000000009417 143.0
TLS2_k127_3628641_17 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000004817 147.0
TLS2_k127_3628641_18 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000003824 108.0
TLS2_k127_3628641_19 Phosphoglycerate mutase family K15634,K22306 - 3.1.3.85,5.4.2.12 0.0000000000000000000004409 104.0
TLS2_k127_3628641_2 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009339 580.0
TLS2_k127_3628641_20 Diguanylate cyclase - - - 0.000000000000000000001691 109.0
TLS2_k127_3628641_21 prohibitin homologues - - - 0.0000000000000107 86.0
TLS2_k127_3628641_23 PFAM regulatory protein, MarR - - - 0.000004031 55.0
TLS2_k127_3628641_24 SPTR D1C1B9 DinB family protein - - - 0.0004566 43.0
TLS2_k127_3628641_3 Protein of unknown function (DUF2867) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 511.0
TLS2_k127_3628641_4 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006464 513.0
TLS2_k127_3628641_5 TIGRFAM TRAP transporter, DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 481.0
TLS2_k127_3628641_6 Predicted membrane protein (DUF2254) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 436.0
TLS2_k127_3628641_7 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 419.0
TLS2_k127_3628641_8 TIGRFAM tripartite ATP-independent periplasmic transporter solute receptor, DctP family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 398.0
TLS2_k127_3628641_9 metal-dependent hydrolase with the TIM-barrel fold K07048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 393.0
TLS2_k127_3753830_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001512 278.0
TLS2_k127_3753830_1 cheY-homologous receiver domain - - - 0.00000000008065 72.0
TLS2_k127_3755626_0 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009745 391.0
TLS2_k127_3755626_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 332.0
TLS2_k127_3755626_10 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.000000000001315 69.0
TLS2_k127_3755626_2 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007468 322.0
TLS2_k127_3755626_3 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005488 307.0
TLS2_k127_3755626_4 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000003548 248.0
TLS2_k127_3755626_5 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000006861 231.0
TLS2_k127_3755626_6 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000000004646 201.0
TLS2_k127_3755626_7 TspO/MBR family K05770 - - 0.0000000000000000000000000000000000000003072 159.0
TLS2_k127_3755626_8 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000007202 135.0
TLS2_k127_3755626_9 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.0000000000000000000000000000001098 144.0
TLS2_k127_3793121_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 412.0
TLS2_k127_3793121_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 407.0
TLS2_k127_3793121_2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000001085 175.0
TLS2_k127_3793121_3 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000002696 121.0
TLS2_k127_3793121_4 PFAM Peptidase family M23 - - - 0.0000000000000000000000006368 114.0
TLS2_k127_3793121_5 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000001147 85.0
TLS2_k127_3793121_6 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000000001294 74.0
TLS2_k127_3793121_7 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0005154 48.0
TLS2_k127_3807374_0 PFAM major facilitator superfamily MFS_1 K08167 - - 2.891e-199 634.0
TLS2_k127_3807374_1 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.00000000000000000000000000000000000000000000000000000000000001505 223.0
TLS2_k127_3807374_11 SnoaL-like domain K06893 - - 0.00000003001 61.0
TLS2_k127_3807374_12 Kelch-like protein 33 K01409,K13957 GO:0000151,GO:0005575,GO:0005622,GO:0005623,GO:0031461,GO:0031463,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1990234 2.3.1.234 0.0001853 53.0
TLS2_k127_3807374_13 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000958 45.0
TLS2_k127_3807374_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000001033 228.0
TLS2_k127_3807374_3 - - - - 0.0000000000000000000000000000000000000000000000000001499 194.0
TLS2_k127_3807374_4 MOSC domain containing protein K07140 - - 0.0000000000000000000000000000000000000000000007718 184.0
TLS2_k127_3807374_5 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000003844 173.0
TLS2_k127_3807374_6 Phosphoesterase K07095 - - 0.00000000000000000000000000000000000000004191 160.0
TLS2_k127_3807374_7 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000002307 134.0
TLS2_k127_3807374_8 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000001173 107.0
TLS2_k127_3807374_9 - - - - 0.0000000002646 67.0
TLS2_k127_3811589_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1011.0
TLS2_k127_3811589_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009854 303.0
TLS2_k127_3954235_0 ATP-dependent peptidase activity K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 597.0
TLS2_k127_3954235_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000007711 233.0
TLS2_k127_3954235_2 TrkA-C domain K03499 - - 0.000000000000000000000000000000000000000000000000000000002372 206.0
TLS2_k127_3954235_3 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.00000000000000000000000000000000000000002247 159.0
TLS2_k127_3954235_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000001972 154.0
TLS2_k127_3954235_5 TrkA-N domain K03499,K10716 - - 0.00000000000000000000000000000000001173 149.0
TLS2_k127_3954235_6 helix_turn_helix, mercury resistance K13640 - - 0.0000000000000003818 87.0
TLS2_k127_3954235_7 Universal stress protein family - - - 0.000000000000003413 82.0
TLS2_k127_3995395_0 Glycosyl hydrolases family 15 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007368 587.0
TLS2_k127_3995395_1 Serine hydrolase involved in the detoxification of formaldehyde - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 509.0
TLS2_k127_3995395_2 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005148 402.0
TLS2_k127_3995395_3 Putative neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005358 286.0
TLS2_k127_3995395_4 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000001262 158.0
TLS2_k127_3995395_5 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000009172 163.0
TLS2_k127_3995395_6 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000000000000000000000000000000174 131.0
TLS2_k127_4005020_0 Dihydropyrimidinase K01464 - 3.5.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003674 616.0
TLS2_k127_4005020_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 376.0
TLS2_k127_4005020_2 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000376 287.0
TLS2_k127_4005020_3 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000001603 228.0
TLS2_k127_4005020_4 PFAM HhH-GPD family protein - - - 0.000000000000000000000000000000000000000000000000000431 198.0
TLS2_k127_4005020_5 glyoxalase - - - 0.0000000000000000000000000000000000000393 153.0
TLS2_k127_4005020_6 translation release factor activity K03265 - - 0.000000000000000000000000000000000005982 152.0
TLS2_k127_4005020_7 PFAM Cupin 2, conserved barrel - - - 0.0001025 46.0
TLS2_k127_4005020_8 GNAT acetyltransferase - - - 0.0006635 52.0
TLS2_k127_4044993_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007629 564.0
TLS2_k127_4044993_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 484.0
TLS2_k127_4044993_10 PFAM Adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000001529 59.0
TLS2_k127_4044993_11 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00001288 48.0
TLS2_k127_4044993_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004308 363.0
TLS2_k127_4044993_3 TIGRFAM metallophosphoesterase, MG_246 BB_0505 family K09769 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 303.0
TLS2_k127_4044993_4 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K04091 - 1.14.14.5 0.0000000000000000000000000000000000000000000000000000000000000000000001304 250.0
TLS2_k127_4044993_5 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000003408 219.0
TLS2_k127_4044993_6 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000007681 214.0
TLS2_k127_4044993_7 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000006966 181.0
TLS2_k127_4044993_8 Lanthionine synthetase C family protein - - - 0.00000000000000000007458 104.0
TLS2_k127_4044993_9 Modulates RecA activity K03565,K19002 GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496 2.4.1.337 0.0000000000000000001663 96.0
TLS2_k127_4079674_0 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 416.0
TLS2_k127_4079674_1 adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000001948 145.0
TLS2_k127_4079674_2 GGDEF domain K02488 - 2.7.7.65 0.000000000000000000000000001216 124.0
TLS2_k127_4079674_3 Pfam:DUF59 - - - 0.000000000003697 68.0
TLS2_k127_4082327_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.954e-282 883.0
TLS2_k127_4082327_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.339e-253 794.0
TLS2_k127_4082327_2 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 329.0
TLS2_k127_4082327_3 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002571 283.0
TLS2_k127_4082327_4 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000374 191.0
TLS2_k127_4082327_5 uracil-DNA K03648 - 3.2.2.27 0.000000000000000000000000006604 126.0
TLS2_k127_4095094_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000613 490.0
TLS2_k127_4095094_1 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 312.0
TLS2_k127_4095094_2 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000002689 103.0
TLS2_k127_4122097_0 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 316.0
TLS2_k127_4122097_1 ABC-2 type transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008849 290.0
TLS2_k127_4166600_0 Type IV secretion-system coupling protein DNA-binding domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000736 531.0
TLS2_k127_4166600_1 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 457.0
TLS2_k127_4166600_10 ACT domain protein - - - 0.000004126 54.0
TLS2_k127_4166600_2 MMPL family K06994,K20470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 434.0
TLS2_k127_4166600_3 L-carnitine dehydratase bile acid-inducible protein F K18702 - 2.8.3.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006334 312.0
TLS2_k127_4166600_4 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000915 278.0
TLS2_k127_4166600_5 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007556 277.0
TLS2_k127_4166600_6 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000002601 205.0
TLS2_k127_4166600_7 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000003477 177.0
TLS2_k127_4166600_8 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000006379 103.0
TLS2_k127_4180691_0 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 498.0
TLS2_k127_4180691_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000008417 232.0
TLS2_k127_4180691_2 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000002135 243.0
TLS2_k127_4180691_3 ABC-type multidrug transport system, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000001939 212.0
TLS2_k127_4180691_4 Immunoglobulin-like domain of bacterial spore germination - - - 0.0000001018 64.0
TLS2_k127_4219370_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 382.0
TLS2_k127_4219370_1 Uracil DNA glycosylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008841 279.0
TLS2_k127_4219370_2 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005281 281.0
TLS2_k127_4219370_4 DNA-binding transcriptional activator of the SARP family - - - 0.0000000000000107 79.0
TLS2_k127_4334082_0 Belongs to the citrate synthase family K01647 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 580.0
TLS2_k127_4334082_1 L-malate dehydrogenase activity K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0030312,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 395.0
TLS2_k127_4334082_2 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 308.0
TLS2_k127_4334082_3 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001523 289.0
TLS2_k127_4334082_4 ABC-2 family transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000009871 214.0
TLS2_k127_4334082_5 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000001777 183.0
TLS2_k127_4334082_6 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000319 167.0
TLS2_k127_4334082_7 Domain of unknown function (DUF4111) - - - 0.0000000000000000000000000000000000000000264 167.0
TLS2_k127_4334082_8 NUDIX domain - - - 0.00000000000000000006359 96.0
TLS2_k127_4334082_9 Polymer-forming cytoskeletal - - - 0.00000000000003071 81.0
TLS2_k127_4361573_0 Amino acid permease - - - 3.277e-201 649.0
TLS2_k127_4361573_1 PFAM FAD dependent oxidoreductase K00301 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 481.0
TLS2_k127_4361573_2 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001751 260.0
TLS2_k127_4361573_3 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000001531 218.0
TLS2_k127_4361573_4 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000002018 123.0
TLS2_k127_4361573_5 Glycosyl hydrolases family 25 - - - 0.00000000000000001167 90.0
TLS2_k127_4361573_6 - - - - 0.00000008391 59.0
TLS2_k127_4410009_0 transferase activity, transferring glycosyl groups K09118,K13693,K21349 - 2.4.1.266,2.4.1.268 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008654 506.0
TLS2_k127_4410009_1 Glycosyl transferase, family 2 K21349 - 2.4.1.268 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 381.0
TLS2_k127_4410009_2 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004839 371.0
TLS2_k127_4410009_3 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 370.0
TLS2_k127_4410009_4 ATPases associated with a variety of cellular activities K11710,K19973 - 3.6.3.35 0.0000000000000000000000000000000000000000000000000000000000000000000008891 245.0
TLS2_k127_4410009_5 ABC-type Mn2 Zn2 transport systems permease components K09819 - - 0.00000000000000000000000000000000000000000000000000000000000000000003397 245.0
TLS2_k127_4410009_6 Belongs to the Fur family K03711 - - 0.0000000000000000001864 102.0
TLS2_k127_4410009_7 DNA polymerase Ligase (LigD) K01971,K10747 GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000001454 72.0
TLS2_k127_4448876_0 TIGRFAM methylmalonyl-CoA mutase, large subunit K01848 - 5.4.99.2 6.747e-221 700.0
TLS2_k127_4448876_1 Histidinol phosphatase and related hydrolases of the PHP family K04477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007144 451.0
TLS2_k127_4448876_10 Dodecin - - - 0.00000000000000000001024 93.0
TLS2_k127_4448876_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 434.0
TLS2_k127_4448876_3 PFAM Fatty acid desaturase, type 2 K03921 - 1.14.19.11,1.14.19.2,1.14.19.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 382.0
TLS2_k127_4448876_4 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 333.0
TLS2_k127_4448876_5 Phosphotriesterase family K07048 - - 0.00000000000000000000000000000000000000000000000000000000000000009308 234.0
TLS2_k127_4448876_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000001723 147.0
TLS2_k127_4448876_7 Tachylectin - - - 0.000000000000000000000000000000000002981 145.0
TLS2_k127_4448876_8 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000007292 124.0
TLS2_k127_4448876_9 - - - - 0.0000000000000000000001401 108.0
TLS2_k127_4450992_0 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 355.0
TLS2_k127_4450992_1 Carboxylate--amine ligase - - - 0.000000000000000000000000000000000000000000002275 175.0
TLS2_k127_4450992_2 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000003992 162.0
TLS2_k127_4450992_3 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000003134 144.0
TLS2_k127_4450992_4 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000000000000000005524 131.0
TLS2_k127_4450992_5 Major Facilitator - - - 0.00001815 49.0
TLS2_k127_4506469_0 peptidase U62, modulator of DNA gyrase K03568 - - 7.719e-222 696.0
TLS2_k127_4506469_1 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 500.0
TLS2_k127_4506469_10 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000726 170.0
TLS2_k127_4506469_11 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000000002867 168.0
TLS2_k127_4506469_12 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000003913 158.0
TLS2_k127_4506469_13 OsmC-like protein K04063 - - 0.00000000000000000000000000000000000005726 147.0
TLS2_k127_4506469_14 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000002178 136.0
TLS2_k127_4506469_15 Acetyltransferase (GNAT) domain K03824 - - 0.00000000000000000000000000000004133 141.0
TLS2_k127_4506469_16 Restriction endonuclease K07448 - - 0.000000000000000000000000000002842 126.0
TLS2_k127_4506469_17 PFAM thioesterase superfamily K07107 - - 0.000000000000000000000000004251 118.0
TLS2_k127_4506469_18 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.000000000000000000000003441 113.0
TLS2_k127_4506469_19 Cytochrome C and Quinol oxidase polypeptide I K00404 - 1.9.3.1 0.0000000000000000000004295 111.0
TLS2_k127_4506469_2 peptidase U62, modulator of DNA gyrase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 412.0
TLS2_k127_4506469_20 sigma-70 region 2 domain protein K03088 - - 0.00000000000000000004458 102.0
TLS2_k127_4506469_21 - - - - 0.0000000000000000002404 93.0
TLS2_k127_4506469_22 NfeD-like C-terminal, partner-binding K07403 - - 0.000000008757 61.0
TLS2_k127_4506469_23 Putative zinc-finger - - - 0.00003628 57.0
TLS2_k127_4506469_25 COG2010 Cytochrome c, mono- and diheme variants - - - 0.0001133 50.0
TLS2_k127_4506469_26 Protein of unknown function (DUF3748) - GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019586,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046397,GO:0071704,GO:0072329,GO:1901575 - 0.0004395 53.0
TLS2_k127_4506469_3 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 349.0
TLS2_k127_4506469_4 galactose-1-phosphate uridylyltransferase K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 317.0
TLS2_k127_4506469_5 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000005825 259.0
TLS2_k127_4506469_6 Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000008353 229.0
TLS2_k127_4506469_7 transcriptional regulator K22491 - - 0.0000000000000000000000000000000000000000000000000000000000525 216.0
TLS2_k127_4506469_8 Predicted membrane protein (DUF2306) - - - 0.0000000000000000000000000000000000000000000000000000003257 205.0
TLS2_k127_4506469_9 MerR, DNA binding K13639 - - 0.00000000000000000000000000000000000000000000000001614 185.0
TLS2_k127_4562986_0 Formate--tetrahydrofolate ligase K01938 - 6.3.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 532.0
TLS2_k127_4562986_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 390.0
TLS2_k127_4562986_10 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000001097 238.0
TLS2_k127_4562986_11 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000003975 221.0
TLS2_k127_4562986_12 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000008727 220.0
TLS2_k127_4562986_13 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07668 GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000399 213.0
TLS2_k127_4562986_14 transmembrane transport K01992 - - 0.0000000000000000000000000000000000000000000000000000000005104 211.0
TLS2_k127_4562986_15 Histidine kinase K07636,K07654 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 2.7.13.3 0.000000000000000000000000000000000000000000000008179 190.0
TLS2_k127_4562986_16 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000002866 145.0
TLS2_k127_4562986_17 Tetratricopeptide repeat - - - 0.000000000000000000000000000000004329 144.0
TLS2_k127_4562986_18 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000007512 131.0
TLS2_k127_4562986_19 MarR family - - - 0.000000000000000000000000007299 116.0
TLS2_k127_4562986_2 ABC transporter, ATP-binding protein K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 372.0
TLS2_k127_4562986_20 cell envelope-related transcriptional attenuator - - - 0.000000000000000000000007229 113.0
TLS2_k127_4562986_21 Dihydroneopterin aldolase K00950,K13940 - 2.7.6.3,4.1.2.25 0.00000000000000003442 92.0
TLS2_k127_4562986_22 general stress protein B in uncultured methanogenic archaeon (Q0W564) - - - 0.0000000000008535 73.0
TLS2_k127_4562986_3 FMN-dependent dehydrogenase K00101,K16422 - 1.1.2.3,1.1.3.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 332.0
TLS2_k127_4562986_4 Belongs to the glycerate kinase type-1 family K00865 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 327.0
TLS2_k127_4562986_5 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008187 332.0
TLS2_k127_4562986_6 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003529 314.0
TLS2_k127_4562986_7 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 311.0
TLS2_k127_4562986_8 PFAM Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000002006 276.0
TLS2_k127_4562986_9 PDZ domain (Also known as DHR or GLGF) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001534 246.0
TLS2_k127_4644630_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 6.411e-201 642.0
TLS2_k127_4644630_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003705 405.0
TLS2_k127_4644630_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000003758 131.0
TLS2_k127_4644630_3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000006782 114.0
TLS2_k127_4701174_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004432 450.0
TLS2_k127_4701174_1 Acyl-CoA dehydrogenase, N-terminal domain K00248,K00249 - 1.3.8.1,1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 392.0
TLS2_k127_4701174_2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004704 310.0
TLS2_k127_4701174_3 helix_turn_helix, mercury resistance - - - 0.000000000000000000000005419 107.0
TLS2_k127_4737321_0 DEAD DEAH box helicase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000751 453.0
TLS2_k127_4737321_1 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000000000000000007922 172.0
TLS2_k127_4737321_2 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000005251 187.0
TLS2_k127_4737321_3 - - - - 0.000000000000000000000000000000000001042 147.0
TLS2_k127_4750979_0 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 393.0
TLS2_k127_4750979_1 L-phenylalanine transmembrane transporter activity K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007529 267.0
TLS2_k127_4750979_2 Transcriptional regulator K22293 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003129 261.0
TLS2_k127_4750979_3 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000005331 143.0
TLS2_k127_4766540_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 7.662e-230 722.0
TLS2_k127_4768225_0 ABC-type branched-chain amino acid transport systems, periplasmic component K01999,K07407 - 3.2.1.22 1.373e-196 623.0
TLS2_k127_4768225_1 L-phenylalanine transmembrane transporter activity K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 461.0
TLS2_k127_4768225_2 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 402.0
TLS2_k127_4768225_3 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 332.0
TLS2_k127_4768225_4 branched-chain amino acid transmembrane transporter activity K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007461 306.0
TLS2_k127_4768225_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007162 300.0
TLS2_k127_4768225_6 Transcriptional regulator K22293 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003361 259.0
TLS2_k127_4768225_7 Psort location Cytoplasmic, score 8.87 K00615 - 2.2.1.1 0.0000000000000000000003014 99.0
TLS2_k127_4789906_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006764 527.0
TLS2_k127_4789906_1 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 312.0
TLS2_k127_4789906_2 ATPases associated with a variety of cellular activities K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001466 289.0
TLS2_k127_4789906_3 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002083 293.0
TLS2_k127_4789906_4 ABC-type nitrate sulfonate bicarbonate transport system, permease component K15554 - - 0.0000000000000000000000000000000000000000000000000000000000000009097 228.0
TLS2_k127_4789906_5 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000001803 229.0
TLS2_k127_4789906_6 AzlC protein - - - 0.00000000000000000000000000000000000000000000000000000000002942 217.0
TLS2_k127_4789906_7 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000126 196.0
TLS2_k127_4789906_8 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000002111 188.0
TLS2_k127_4789906_9 Cytochrome C biogenesis protein - - - 0.00000000000000000000000000000266 127.0
TLS2_k127_4824550_0 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000005643 163.0
TLS2_k127_4824550_1 Amidohydrolase family - - - 0.0000000000000000000000001886 121.0
TLS2_k127_4824550_2 Amidohydrolase family - - - 0.00001125 58.0
TLS2_k127_4862416_0 AAA ATPase domain - - - 0.0 1161.0
TLS2_k127_4862416_1 Transcriptional regulatory protein, C terminal K07667 - - 0.00000000000000000000000000000008204 134.0
TLS2_k127_4862416_2 Acetyltransferase (GNAT) family - - - 0.000000000000000000001858 103.0
TLS2_k127_4862416_3 SnoaL-like polyketide cyclase - - - 0.0000000003503 67.0
TLS2_k127_4866487_0 peptidase K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005554 314.0
TLS2_k127_4866487_1 Thioesterase superfamily K07107 - - 0.00000000000000000000000005901 112.0
TLS2_k127_4866487_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00002377 56.0
TLS2_k127_4960198_0 Histidine kinase K07680,K07778,K11617,K14988 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000234 233.0
TLS2_k127_4960198_1 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000002108 216.0
TLS2_k127_4960198_2 Two component transcriptional regulator, LuxR family - - - 0.000000000000000000000000000000000000000000000000000000000007933 220.0
TLS2_k127_4960198_3 ubiE/COQ5 methyltransferase family - - - 0.0000000000002157 81.0
TLS2_k127_4997615_0 TOBE domain K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005533 447.0
TLS2_k127_4997615_1 PFAM Glycoside hydrolase, family 38 K01191,K15524 - 3.2.1.170,3.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 439.0
TLS2_k127_4997615_2 Binding-protein-dependent transport system inner membrane component K10234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 305.0
TLS2_k127_4997615_3 Bacterial extracellular solute-binding protein K02027,K10232 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006571 254.0
TLS2_k127_4997615_4 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000003412 241.0
TLS2_k127_4997615_5 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000007397 123.0
TLS2_k127_4997615_6 Transglycosylase associated protein - - - 0.000000000000005295 81.0
TLS2_k127_4997615_7 DNA binding - - - 0.0000000000006622 77.0
TLS2_k127_4997615_8 Endonuclease/Exonuclease/phosphatase family - - - 0.00000007246 65.0
TLS2_k127_5009235_0 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 3.842e-242 762.0
TLS2_k127_5009235_1 Carbamoyl-phosphate synthetase large chain domain protein K01968 - 6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 492.0
TLS2_k127_5009235_2 COG1192 ATPases involved in chromosome partitioning K03496 GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000443 233.0
TLS2_k127_5009235_3 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000001623 213.0
TLS2_k127_5009235_4 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000002755 173.0
TLS2_k127_5009235_5 CoA-binding protein K06929 - - 0.000000000000000000000002873 109.0
TLS2_k127_5021239_0 PFAM Amidohydrolase 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004044 296.0
TLS2_k127_5021239_1 Glycosyl transferase, family 2 K19003 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046872,GO:0071704,GO:1901576 2.4.1.336 0.000000000000000000000000000000000000000000000571 182.0
TLS2_k127_5021239_2 Cold shock protein domain - - - 0.0000593 55.0
TLS2_k127_5032537_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 542.0
TLS2_k127_5032537_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 467.0
TLS2_k127_5032537_10 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000008172 209.0
TLS2_k127_5032537_11 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000837 203.0
TLS2_k127_5032537_12 ABC transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000001865 200.0
TLS2_k127_5032537_13 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000001964 180.0
TLS2_k127_5032537_14 Nickel-containing superoxide dismutase K00518 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.15.1.1 0.0000000000000000000000000000000000000000001433 163.0
TLS2_k127_5032537_15 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000000000000000000000000000001257 168.0
TLS2_k127_5032537_16 permease - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.0000000000000000000000000000000001422 155.0
TLS2_k127_5032537_17 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000001018 121.0
TLS2_k127_5032537_18 - - - - 0.0000000000000000000000001682 118.0
TLS2_k127_5032537_19 Belongs to the sigma-70 factor family - - - 0.0000000000000000000000002581 113.0
TLS2_k127_5032537_2 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 429.0
TLS2_k127_5032537_20 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000001864 103.0
TLS2_k127_5032537_21 AMP-binding enzyme C-terminal domain K00666 - - 0.00000000000000004499 86.0
TLS2_k127_5032537_22 Peptidase S24-like - - - 0.000000000006101 72.0
TLS2_k127_5032537_23 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000001707 63.0
TLS2_k127_5032537_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 350.0
TLS2_k127_5032537_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 316.0
TLS2_k127_5032537_5 Tryptophanyl-tRNA synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 304.0
TLS2_k127_5032537_6 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 305.0
TLS2_k127_5032537_7 reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005164 279.0
TLS2_k127_5032537_8 ABC-type Fe3 -siderophore transport system, permease component K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008293 261.0
TLS2_k127_5032537_9 malonyl CoA-acyl carrier protein transacylase K00645 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000002241 244.0
TLS2_k127_5060605_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 411.0
TLS2_k127_5060605_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000002218 189.0
TLS2_k127_5060605_2 Methyltransferase K08316 - 2.1.1.171 0.0000000000000000000000000000002811 130.0
TLS2_k127_5060605_3 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.0000000000000000001354 95.0
TLS2_k127_5060605_4 Uncharacterized ACR, COG1399 K07040 - - 0.00000009001 62.0
TLS2_k127_5075848_0 UDP-glucoronosyl and UDP-glucosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 548.0
TLS2_k127_5075848_1 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 387.0
TLS2_k127_5075848_2 helix_turn_helix ASNC type K03718 - - 0.00000000000000000000000000000000000000000000000000000002239 201.0
TLS2_k127_5075848_3 Bacterial extracellular solute-binding protein - - - 0.0000000001628 66.0
TLS2_k127_5232434_0 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000001579 218.0
TLS2_k127_5232434_1 Psort location Cytoplasmic, score 8.87 - - - 0.00000000000000000000000003717 114.0
TLS2_k127_5234729_0 GTP-binding protein TypA K06207 - - 5.067e-214 685.0
TLS2_k127_5234729_1 CobW/HypB/UreG, nucleotide-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 546.0
TLS2_k127_5234729_10 ABC-2 family transporter protein K01992,K18233 - - 0.0000000000000000000000000000000000000000000000000000000000001369 223.0
TLS2_k127_5234729_11 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000003472 226.0
TLS2_k127_5234729_12 - - - - 0.00000000000000000000000000000000000000000000000000000000006541 217.0
TLS2_k127_5234729_13 COG0471 Di- and tricarboxylate transporters K14445 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0034220,GO:0044425,GO:0051179,GO:0051234,GO:0055085,GO:0098656 - 0.000000000000000000000000000000000000000000000000000000008628 219.0
TLS2_k127_5234729_14 response to heat K03668,K09914 - - 0.000000000000000000000000000000000000000000000000001958 192.0
TLS2_k127_5234729_15 Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000006764 190.0
TLS2_k127_5234729_16 transcriptional regulator - - - 0.0000000000000000000000000000000000005866 146.0
TLS2_k127_5234729_17 Protein of unknown function (DUF3037) - - - 0.000000000000000000000000000000002974 136.0
TLS2_k127_5234729_18 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000003923 145.0
TLS2_k127_5234729_19 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000004889 144.0
TLS2_k127_5234729_2 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004078 415.0
TLS2_k127_5234729_20 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000703 136.0
TLS2_k127_5234729_21 Methyltransferase - - - 0.000000000000000000000003949 109.0
TLS2_k127_5234729_22 Luciferase-like monooxygenase - - - 0.0000000000000000116 84.0
TLS2_k127_5234729_23 Bacterial regulatory proteins, tetR family K22108 - - 0.000007246 56.0
TLS2_k127_5234729_24 PFAM Hemolysin-type calcium-binding region - - - 0.0000179 57.0
TLS2_k127_5234729_25 - - - - 0.0004458 49.0
TLS2_k127_5234729_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004688 395.0
TLS2_k127_5234729_4 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 391.0
TLS2_k127_5234729_5 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 349.0
TLS2_k127_5234729_6 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009493 341.0
TLS2_k127_5234729_7 Serine threonine protein kinase involved in cell cycle control - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008913 265.0
TLS2_k127_5234729_8 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009751 258.0
TLS2_k127_5234729_9 NADPH-dependent FMN reductase K00299 - 1.5.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000003468 246.0
TLS2_k127_5250234_0 Berberine and berberine like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009613 428.0
TLS2_k127_5250234_1 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 360.0
TLS2_k127_5250234_2 Belongs to the peptidase S8 family K14645 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001147 267.0
TLS2_k127_5250234_3 transcriptional regulator K10914 GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - 0.00000000000000000000000000000000000000000008396 170.0
TLS2_k127_5250234_4 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000005291 170.0
TLS2_k127_5250234_5 ECF sigma factor K03088 - - 0.00000000000000000000003174 106.0
TLS2_k127_5250234_6 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000006037 106.0
TLS2_k127_5250234_7 GAF domain - - - 0.000000000000000000001048 106.0
TLS2_k127_5251224_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004724 459.0
TLS2_k127_5251224_1 Acetyltransferase (GNAT) family - - - 0.000003231 58.0
TLS2_k127_5388391_0 Methyltransferase small domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005448 383.0
TLS2_k127_5388391_1 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005049 319.0
TLS2_k127_5388391_2 50S ribosome-binding GTPase - - - 0.000000000000000000000000000000000000000000000005601 192.0
TLS2_k127_5388391_3 Sugar efflux transporter for intercellular exchange K15383 - - 0.00000000000000000006133 96.0
TLS2_k127_5428977_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 302.0
TLS2_k127_5428977_1 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000001158 192.0
TLS2_k127_5428977_2 Tellurite resistance protein TerB - - - 0.0000000000000000000002717 106.0
TLS2_k127_5647066_0 amine oxidase K06954 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004888 370.0
TLS2_k127_5647066_1 PFAM Cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 349.0
TLS2_k127_5647066_10 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.00000000000000002933 82.0
TLS2_k127_5647066_11 - - - - 0.00000000000000007211 93.0
TLS2_k127_5647066_12 Virulence factor BrkB K07058 - - 0.0000000284 64.0
TLS2_k127_5647066_2 Adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008597 335.0
TLS2_k127_5647066_3 tetrahydromethanopterin reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006503 298.0
TLS2_k127_5647066_4 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000736 275.0
TLS2_k127_5647066_5 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000003394 192.0
TLS2_k127_5647066_6 Protein of unknown function (DUF1365) K09701 - - 0.000000000000000000000000000000000000000000001295 181.0
TLS2_k127_5647066_7 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000005422 181.0
TLS2_k127_5647066_8 MerR family regulatory protein - - - 0.00000000000000000000000003832 124.0
TLS2_k127_5647066_9 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000009521 117.0
TLS2_k127_5672492_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000003542 181.0
TLS2_k127_5672492_1 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000549 138.0
TLS2_k127_5707230_0 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001417 262.0
TLS2_k127_5707230_1 ABC transporter (Permease) K02004 - - 0.000000000000000000000000000000000000000000000000002551 207.0
TLS2_k127_5707230_2 - - - - 0.0000000000000000000000000000000000000000004205 181.0
TLS2_k127_5707230_3 Domain of unknown function (DUF296) K06934 - - 0.0000000000000000000000000000005868 126.0
TLS2_k127_5707230_4 COG0791 Cell wall-associated hydrolases (invasion-associated proteins) - - - 0.0000000002666 69.0
TLS2_k127_5707230_5 Stigma-specific protein, Stig1 - - - 0.0000000484 66.0
TLS2_k127_5707230_6 transcriptional regulator, SARP family - - - 0.00001221 55.0
TLS2_k127_5728581_0 aromatic amino acid beta-eliminating lyase threonine aldolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 432.0
TLS2_k127_5728581_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472,K13015 - 1.1.1.136,1.1.1.336 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 434.0
TLS2_k127_5728581_10 PAS fold K20960 - 2.7.7.65 0.0000000000000000000000000000004893 142.0
TLS2_k127_5728581_11 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.000000000000000000006897 108.0
TLS2_k127_5728581_2 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 396.0
TLS2_k127_5728581_3 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009399 332.0
TLS2_k127_5728581_4 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002434 272.0
TLS2_k127_5728581_5 MazG nucleotide pyrophosphohydrolase domain K02428,K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66,3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000002904 263.0
TLS2_k127_5728581_6 Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000000005886 251.0
TLS2_k127_5728581_7 PFAM transferase hexapeptide repeat containing protein - - - 0.0000000000000000000000000000000000000000000000000001192 189.0
TLS2_k127_5728581_8 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000002756 204.0
TLS2_k127_5728581_9 Cell envelope-related transcriptional attenuator domain - - - 0.0000000000000000000000000000001009 143.0
TLS2_k127_5758018_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008707 467.0
TLS2_k127_5758018_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000006506 248.0
TLS2_k127_5758018_2 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000004137 246.0
TLS2_k127_5758018_3 Putative neutral zinc metallopeptidase K06973 - - 0.000000000000000000000000000000000000000000000000007509 190.0
TLS2_k127_5758018_4 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000323 166.0
TLS2_k127_5758018_5 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.000000000000000000000000000000000000002373 159.0
TLS2_k127_5758018_6 BON domain - - - 0.0001362 52.0
TLS2_k127_5793278_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 590.0
TLS2_k127_5793278_1 DNA segregation ATPase FtsK SpoIIIE K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 487.0
TLS2_k127_5793278_2 Mur ligase family, catalytic domain K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004352 282.0
TLS2_k127_5793278_3 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000006572 215.0
TLS2_k127_5793278_4 Belongs to the UPF0234 family K09767 - - 0.000000000000000000000000000000000000000000000000000000004289 203.0
TLS2_k127_5793278_5 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0000000000000000000000000000000000000001103 153.0
TLS2_k127_5793278_6 Competence-damaged protein K03743 - 3.5.1.42 0.00000000000000000000000000000002087 132.0
TLS2_k127_5793278_7 SMART helix-turn-helix domain protein - - - 0.0000000000000000002937 101.0
TLS2_k127_581698_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006133 512.0
TLS2_k127_581698_1 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004222 480.0
TLS2_k127_581698_2 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008602 443.0
TLS2_k127_581698_3 PFAM alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009566 252.0
TLS2_k127_581698_4 XdhC and CoxI family - - - 0.000000000000000000000000000000000000000000000000000000000002289 224.0
TLS2_k127_581698_5 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000002891 207.0
TLS2_k127_581698_6 FAD linked oxidase - - - 0.0000000000000000000000000000000000000003716 151.0
TLS2_k127_581698_7 Required for disulfide bond formation in some proteins K03611 - - 0.0000000000000000000000000000000000362 141.0
TLS2_k127_581698_8 Redoxin - - - 0.00000000000000000000000000001337 132.0
TLS2_k127_5909165_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006366 465.0
TLS2_k127_5909165_1 PFAM ABC transporter related K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 330.0
TLS2_k127_5909165_2 Uncharacterized protein family (UPF0051) K09014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 304.0
TLS2_k127_5909165_3 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002334 259.0
TLS2_k127_5909165_4 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000003336 143.0
TLS2_k127_5909165_5 Transcriptional regulator - - - 0.000000000000000000000000001115 118.0
TLS2_k127_5909165_6 of nitrite reductase and ring-hydroxylating K05710 - - 0.000000000000000000000009243 104.0
TLS2_k127_5909165_7 Rhodanese Homology Domain - - - 0.000000000000005069 82.0
TLS2_k127_5956300_0 Stage II sporulation E family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 495.0
TLS2_k127_5956300_1 Transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 494.0
TLS2_k127_5956300_10 - - - - 0.0005947 51.0
TLS2_k127_5956300_2 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0000000000000000000000000000000000000000000000000000000000000000007875 237.0
TLS2_k127_5956300_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000001781 177.0
TLS2_k127_5956300_4 Histidine kinase - - - 0.0000000000000000000000000000000000002789 155.0
TLS2_k127_5956300_5 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000005181 133.0
TLS2_k127_5956300_6 antisigma factor binding K03090,K04749,K06378 - - 0.000000000000000000000000000001256 124.0
TLS2_k127_5956300_7 antisigma factor binding K04749 - - 0.000000000000000000001521 97.0
TLS2_k127_5956300_8 F420H(2)-dependent quinone reductase - - - 0.00000000000000000002538 100.0
TLS2_k127_5956300_9 Subtilase family - - - 0.000000288 61.0
TLS2_k127_6136111_0 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009445 310.0
TLS2_k127_6136111_1 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 294.0
TLS2_k127_6136111_10 pyridoxamine 5'-phosphate K07005 - - 0.00000000000000000000004889 104.0
TLS2_k127_6136111_11 lipid kinase activity - - - 0.000000000000002599 87.0
TLS2_k127_6136111_12 PFAM pyridoxamine 5'-phosphate oxidase-related - - - 0.000000000000006255 80.0
TLS2_k127_6136111_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000009551 238.0
TLS2_k127_6136111_3 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.0000000000000000000000000000000000000000000000000000000001528 214.0
TLS2_k127_6136111_4 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000001528 211.0
TLS2_k127_6136111_5 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000001919 182.0
TLS2_k127_6136111_6 Amidohydrolase family K01464 - 3.5.2.2 0.000000000000000000000000000000000001561 140.0
TLS2_k127_6136111_7 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000000000000000000000000000000003774 139.0
TLS2_k127_6136111_8 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000001748 129.0
TLS2_k127_6136548_0 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008395 580.0
TLS2_k127_6136548_1 Isocitrate lyase K01637 GO:0003674,GO:0003824,GO:0004451,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046421,GO:0046487,GO:0071704,GO:0072350 4.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008187 420.0
TLS2_k127_6136548_2 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007669 275.0
TLS2_k127_6136548_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000356 265.0
TLS2_k127_6136548_4 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000004378 244.0
TLS2_k127_6136548_5 Uncharacterized protein family UPF0016 - - - 0.0000000000000000000000000000000000000225 160.0
TLS2_k127_6174941_0 ATPases associated with a variety of cellular activities K02028,K02030,K09972 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 389.0
TLS2_k127_6174941_1 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K09970 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 352.0
TLS2_k127_6174941_2 Binding-protein-dependent transport system inner membrane component K09971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 344.0
TLS2_k127_6174941_3 Integral membrane protein TerC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 311.0
TLS2_k127_6174941_4 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002105 270.0
TLS2_k127_62144_0 Domain of unknown function (DUF368) K08974 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000484 276.0
TLS2_k127_62144_1 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.0000000000000000000000000000000000000000000000000000000001319 222.0
TLS2_k127_62144_2 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000003151 188.0
TLS2_k127_62144_3 Peptidase family M3 K01392 - 3.4.24.15 0.0000000000000000000000000000000000000000000000001767 194.0
TLS2_k127_62144_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000001084 190.0
TLS2_k127_62144_5 Protein of unknown function (DUF1761) - - - 0.00000000000000000000004361 104.0
TLS2_k127_62144_6 S-layer homology domain - - - 0.00000000000001104 87.0
TLS2_k127_62144_7 Glyoxalase-like domain - - - 0.000008878 51.0
TLS2_k127_6251664_0 Belongs to the amidase family K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 428.0
TLS2_k127_6301764_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005255 441.0
TLS2_k127_6301764_1 NUBPL iron-transfer P-loop NTPase K02282 - - 0.0000000000000000000000000009698 127.0
TLS2_k127_6301764_2 Regulatory protein, FmdB family - - - 0.0000000000000001791 84.0
TLS2_k127_6422820_0 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000001041 109.0
TLS2_k127_6422820_1 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000007309 63.0
TLS2_k127_6467566_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 1.493e-293 945.0
TLS2_k127_6467566_1 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005511 280.0
TLS2_k127_6467566_2 membrane - - - 0.00000000000000000000000000000000000042 150.0
TLS2_k127_6467566_3 COG1196 Chromosome segregation ATPases - - - 0.000000000000000000000001292 116.0
TLS2_k127_6653741_0 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002505 343.0
TLS2_k127_6653741_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004175 296.0
TLS2_k127_6653741_2 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000001284 219.0
TLS2_k127_6653741_3 Glycosyl transferase K00728 - 2.4.1.109 0.0000000000000000000000000000000000000000000000004015 204.0
TLS2_k127_6653741_4 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000003237 196.0
TLS2_k127_6653741_5 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000001745 153.0
TLS2_k127_6653741_6 SMART protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.0000000007162 73.0
TLS2_k127_6691233_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.926e-265 831.0
TLS2_k127_6691233_1 Heat shock 70 kDa protein K04043 - - 7.173e-259 813.0
TLS2_k127_6691233_10 pfam rok K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000005727 239.0
TLS2_k127_6691233_11 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000002408 158.0
TLS2_k127_6691233_12 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000000000000000000165 146.0
TLS2_k127_6691233_13 VanW like protein - - - 0.000000000000000000000000000000006141 148.0
TLS2_k127_6691233_14 - - - - 0.0000000000000000003187 87.0
TLS2_k127_6691233_15 - - - - 0.0000000000002986 84.0
TLS2_k127_6691233_16 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000003856 76.0
TLS2_k127_6691233_17 - - - - 0.000005109 55.0
TLS2_k127_6691233_18 CAAX protease self-immunity K07052 - - 0.0001224 52.0
TLS2_k127_6691233_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 600.0
TLS2_k127_6691233_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 492.0
TLS2_k127_6691233_4 Belongs to the phosphoglycerate kinase family K00927 GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 447.0
TLS2_k127_6691233_5 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006147 379.0
TLS2_k127_6691233_6 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003006 276.0
TLS2_k127_6691233_7 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002544 267.0
TLS2_k127_6691233_8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004959 266.0
TLS2_k127_6691233_9 Phosphorylase superfamily K00757 GO:0003674,GO:0003824,GO:0004850,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006218,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016043,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0022607,GO:0030955,GO:0031420,GO:0033554,GO:0034214,GO:0034641,GO:0034655,GO:0034656,GO:0042454,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046108,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0050896,GO:0051259,GO:0051716,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.3 0.000000000000000000000000000000000000000000000000000000000000000003024 237.0
TLS2_k127_6700694_0 extracellular solute-binding protein, family 3 K09969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007037 369.0
TLS2_k127_6700694_1 Pyridoxamine 5'-phosphate oxidase - - - 0.00000003335 66.0
TLS2_k127_6700694_2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K13053,K14160 - - 0.0004444 50.0
TLS2_k127_672504_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 3.737e-291 913.0
TLS2_k127_672504_1 Domain of unknown function (DUF3459) K01236 - 3.2.1.141 5.88e-227 716.0
TLS2_k127_672504_10 Aldose 1-epimerase K01785 - 5.1.3.3 0.00000000000000000000002188 111.0
TLS2_k127_672504_2 protein involved in exopolysaccharide biosynthesis - - - 1.052e-202 649.0
TLS2_k127_672504_3 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 573.0
TLS2_k127_672504_4 PFAM glycoside hydrolase family 77 K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 489.0
TLS2_k127_672504_5 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 334.0
TLS2_k127_672504_6 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 317.0
TLS2_k127_672504_7 COG4213 ABC-type xylose transport system, periplasmic component K10543 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 300.0
TLS2_k127_672504_8 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000001336 218.0
TLS2_k127_672504_9 synthase K00705,K06044 GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 0.00000000000000000000000000000000000000004978 157.0
TLS2_k127_6735751_0 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000001491 213.0
TLS2_k127_6735751_1 HD domain - - - 0.0000000000000000000000000000000000000000000005448 174.0
TLS2_k127_6735751_2 Two component, sigma54 specific, transcriptional regulator, Fis family K07712,K07714 - - 0.0000000000000000000000000000000000792 139.0
TLS2_k127_6815808_0 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 602.0
TLS2_k127_6815808_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 567.0
TLS2_k127_6815808_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00002134 54.0
TLS2_k127_6815808_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 525.0
TLS2_k127_6815808_3 aconitate hydratase K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006294 387.0
TLS2_k127_6815808_4 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008737 295.0
TLS2_k127_6815808_5 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000001055 231.0
TLS2_k127_6815808_6 Domain of unknown function (DUF4111) K00984 - 2.7.7.47 0.000000000000000000000000000000000000000000000000000000000004992 219.0
TLS2_k127_6815808_7 YibE F family protein - - - 0.0000000000000000000000000000000000000000000000003001 191.0
TLS2_k127_6815808_8 PFAM Nucleotidyl transferase K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000005326 149.0
TLS2_k127_6815808_9 acetyltransferase - - - 0.000000000000000000018 102.0
TLS2_k127_691777_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 1.066e-297 940.0
TLS2_k127_691777_1 synthase K06044 - 5.4.99.15 2.526e-232 740.0
TLS2_k127_691777_2 Phosphotransferase enzyme family K00700,K05343,K16146 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 0.00000000000000000000000000000000000000000000000000000000000000000001038 249.0
TLS2_k127_6947057_0 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 349.0
TLS2_k127_6947057_1 SMART protein phosphatase 2C domain protein K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000002613 213.0
TLS2_k127_6947057_2 Aminotransferase K00817,K04720 GO:0008150,GO:0040007 2.6.1.9,4.1.1.81 0.00000000000000001968 84.0
TLS2_k127_6947057_3 heme oxygenase (decyclizing) activity K07145,K21481 - 1.14.99.48,1.14.99.57 0.0000497 55.0
TLS2_k127_694962_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 5.558e-209 664.0
TLS2_k127_694962_1 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 5.779e-201 661.0
TLS2_k127_694962_10 - - - - 0.00000000000000005309 83.0
TLS2_k127_694962_11 Belongs to the UPF0145 family - - - 0.0000000000000002944 79.0
TLS2_k127_694962_12 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000008391 59.0
TLS2_k127_694962_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 436.0
TLS2_k127_694962_3 AAA domain K07133 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 424.0
TLS2_k127_694962_4 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007216 362.0
TLS2_k127_694962_5 PFAM SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 332.0
TLS2_k127_694962_6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000005649 165.0
TLS2_k127_694962_7 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000006451 144.0
TLS2_k127_694962_8 Mg2 transporter-C family protein K07507 - - 0.0000000000000000000000000000000000734 139.0
TLS2_k127_694962_9 Clp amino terminal domain, pathogenicity island component - - - 0.00000000000000000000002892 108.0
TLS2_k127_6969818_0 Belongs to the transketolase family K00615 - 2.2.1.1 3.743e-256 810.0
TLS2_k127_6969818_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 3.419e-198 631.0
TLS2_k127_6969818_10 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001427 274.0
TLS2_k127_6969818_11 Putative glutamine amidotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002169 248.0
TLS2_k127_6969818_12 Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000000000000000000000000000142 223.0
TLS2_k127_6969818_13 Isochorismatase family K08281 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 0.00000000000000000000000000000000000000000000000000000000003059 211.0
TLS2_k127_6969818_14 PFAM glucosamine galactosamine-6-phosphate isomerase K01057 - 3.1.1.31 0.0000000000000000000000000000000000000000000000002268 188.0
TLS2_k127_6969818_15 Glucose-6-phosphate dehydrogenase subunit - - - 0.00000000000000000000000000000000000000005114 175.0
TLS2_k127_6969818_16 Probable zinc-ribbon domain - - - 0.000000000000000000000000000004868 126.0
TLS2_k127_6969818_17 - - - - 0.00000007156 57.0
TLS2_k127_6969818_18 Conserved Protein - - - 0.0004358 48.0
TLS2_k127_6969818_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 452.0
TLS2_k127_6969818_3 Required for the activity of the bacterial periplasmic transport system of putrescine K11069 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005313 429.0
TLS2_k127_6969818_4 TIGRFAM 6-phosphogluconate dehydrogenase, decarboxylating K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 344.0
TLS2_k127_6969818_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11076 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 350.0
TLS2_k127_6969818_6 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 332.0
TLS2_k127_6969818_7 Binding-protein-dependent transport system inner membrane component K02054,K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 329.0
TLS2_k127_6969818_8 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004049 334.0
TLS2_k127_6969818_9 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000535 336.0
TLS2_k127_6988610_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 1.182e-238 758.0
TLS2_k127_6988610_1 Cytochrome C assembly protein K02198,K04016 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 529.0
TLS2_k127_6988610_10 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00000000000000000000000000000000000000000000000002061 192.0
TLS2_k127_6988610_11 YceI-like domain - - - 0.00000000000000000000000000000000000000000000001305 177.0
TLS2_k127_6988610_12 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000000001837 164.0
TLS2_k127_6988610_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000002213 151.0
TLS2_k127_6988610_14 Thiol-disulfide isomerase-like thioredoxin K02199 - - 0.0000000000000000000000000000000000761 139.0
TLS2_k127_6988610_15 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050 - - 0.00000000000000000001824 101.0
TLS2_k127_6988610_16 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000006707 98.0
TLS2_k127_6988610_17 subunit of a heme lyase K02200 - - 0.0000000000000000003293 95.0
TLS2_k127_6988610_18 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000007138 89.0
TLS2_k127_6988610_19 EamA-like transporter family K15269 - - 0.000000000000001156 88.0
TLS2_k127_6988610_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 382.0
TLS2_k127_6988610_3 phosphate binding protein K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 355.0
TLS2_k127_6988610_4 Methyltransferase type 11 K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 337.0
TLS2_k127_6988610_5 phosphate binding protein K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 309.0
TLS2_k127_6988610_6 Binding-protein-dependent transport system inner membrane component K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 293.0
TLS2_k127_6988610_7 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001649 278.0
TLS2_k127_6988610_8 Transcriptional regulatory protein, C terminal K07658 - - 0.0000000000000000000000000000000000000000000000000000000000000000008285 235.0
TLS2_k127_6988610_9 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000001396 238.0
TLS2_k127_70508_0 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 482.0
TLS2_k127_70508_1 AP endonuclease family 2 C terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 442.0
TLS2_k127_70508_2 Transcriptional regulator sugar kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 449.0
TLS2_k127_70508_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 393.0
TLS2_k127_70508_4 Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion K02564 - 3.5.99.6 0.00000000000000000000000000000000000002021 153.0
TLS2_k127_70508_5 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000001424 80.0
TLS2_k127_7096935_0 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001557 280.0
TLS2_k127_7096935_1 Predicted membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001149 272.0
TLS2_k127_7096935_2 ABC-type cobalt transport system, permease component K16925 - - 0.00000000000000000000000000000000000000000000000000002741 197.0
TLS2_k127_7096935_3 YbaK prolyl-tRNA synthetase associated region - - - 0.00000000000000000000000000000000000000000005266 165.0
TLS2_k127_7096935_4 PFAM Thiamin pyrophosphokinase, catalytic region K00949 - 2.7.6.2 0.0000000000000000000000000000000000000843 151.0
TLS2_k127_7096935_5 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000005553 163.0
TLS2_k127_7096935_6 GAF domain - - - 0.00000000000000000000000000000000001996 158.0
TLS2_k127_7099815_0 Ser Thr phosphatase family protein K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 310.0
TLS2_k127_7099815_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000004329 183.0
TLS2_k127_7099815_2 serine-type aminopeptidase activity - - - 0.0000000000000000000000000000000007221 146.0
TLS2_k127_7099815_3 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.0000000000000000000000006997 119.0
TLS2_k127_7099815_4 Serine aminopeptidase, S33 K06889 - - 0.0000000000000000003167 99.0
TLS2_k127_7111279_0 DEAD/H associated K03724 - - 0.0 1561.0
TLS2_k127_7111279_1 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K02029 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 347.0
TLS2_k127_7111279_2 Binding-protein-dependent transport system inner membrane component K02029,K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008744 299.0
TLS2_k127_7111279_3 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008911 267.0
TLS2_k127_7111279_4 DoxX K16937 - 1.8.5.2 0.000000000000000000000000000000000000000000000000000000000000004043 226.0
TLS2_k127_7111279_5 Transcriptional regulatory protein, C terminal K07667 - - 0.000000000000000000000000000000000000000000000000000004048 205.0
TLS2_k127_7111279_6 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000001197 109.0
TLS2_k127_7111279_7 Bacterial periplasmic substrate-binding proteins K02030,K02424,K17073 - - 0.0000000000000000003271 89.0
TLS2_k127_7115956_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 591.0
TLS2_k127_7115956_1 TIGRFAM phenylacetate-CoA oxygenase, PaaG subunit K02609 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 456.0
TLS2_k127_7115956_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000000003337 202.0
TLS2_k127_7115956_3 TIGRFAM Phenylacetate-CoA oxygenase, PaaI subunit K02611 - 1.14.13.149 0.000000000000000000000000000000000000000000000000008273 195.0
TLS2_k127_7115956_4 TIGRFAM phenylacetate-CoA oxygenase, PaaJ subunit K02612 - - 0.0000000000000000000000000000000000000000000157 175.0
TLS2_k127_7115956_5 phenylacetate catabolic process K02610 - - 0.0000000000000000000001815 100.0
TLS2_k127_7115956_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00003535 51.0
TLS2_k127_7117577_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 485.0
TLS2_k127_7117577_1 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 465.0
TLS2_k127_7117577_2 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001308 280.0
TLS2_k127_7117577_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000004394 228.0
TLS2_k127_7117577_4 Protein of unknown function (DUF3105) - - - 0.000000000000000000000000000936 123.0
TLS2_k127_7117577_5 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000001945 58.0
TLS2_k127_7225654_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 5.992e-266 827.0
TLS2_k127_7225654_1 TIGRFAM Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 462.0
TLS2_k127_7225654_2 TIGRFAM tRNA-guanine transglycosylase, various specificities K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007334 368.0
TLS2_k127_7225654_3 PFAM Formiminotransferase domain, N-terminal subdomain K00603,K01746 - 2.1.2.5,4.3.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 301.0
TLS2_k127_7225654_4 Tetrapyrrole (Corrin/Porphyrin) Methylases K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000001137 258.0
TLS2_k127_7225654_5 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000004513 186.0
TLS2_k127_7225654_6 Zn peptidase - - - 0.000000000000000000000000000000000000000005203 171.0
TLS2_k127_7225654_7 PFAM ribosomal RNA methyltransferase K18845 - 2.1.1.179 0.00000000000000000000000000000000000003082 153.0
TLS2_k127_7225654_8 SIS domain K00820 - 2.6.1.16 0.000000000000000001525 98.0
TLS2_k127_7225654_9 Acetyltransferase (GNAT) family - - - 0.0003357 51.0
TLS2_k127_7235988_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K00058,K03977 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 488.0
TLS2_k127_7235988_1 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 353.0
TLS2_k127_7235988_10 PFAM peptidase M50 - - - 0.00000000000000000000000000000000000002818 151.0
TLS2_k127_7235988_11 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.00000000000000000000000000000000000004405 151.0
TLS2_k127_7235988_12 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000001835 145.0
TLS2_k127_7235988_13 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000001193 125.0
TLS2_k127_7235988_14 Glycosyl hydrolases family 25 - - - 0.000000000000000000000004662 114.0
TLS2_k127_7235988_15 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000012 96.0
TLS2_k127_7235988_16 mRNA catabolic process - - - 0.000000000000000001716 91.0
TLS2_k127_7235988_17 Cold shock K03704 - - 0.000000000003369 68.0
TLS2_k127_7235988_18 Protein of unknown function (DUF1461) - - - 0.000000000149 71.0
TLS2_k127_7235988_2 Amidohydrolase family K01487 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008892,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0016814,GO:0018756,GO:0019239,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046098,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564 3.5.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 308.0
TLS2_k127_7235988_20 PFAM response regulator receiver - - - 0.000008958 57.0
TLS2_k127_7235988_21 - - - - 0.000285 48.0
TLS2_k127_7235988_3 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 292.0
TLS2_k127_7235988_4 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001549 304.0
TLS2_k127_7235988_5 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000001033 260.0
TLS2_k127_7235988_6 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000001232 227.0
TLS2_k127_7235988_7 Belongs to the pseudouridine synthase RsuA family K06178,K06182 - 5.4.99.21,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000001412 224.0
TLS2_k127_7235988_8 PAS fold - - - 0.000000000000000000000000000000000000000000000102 191.0
TLS2_k127_7235988_9 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000006948 177.0
TLS2_k127_7300782_0 Radical SAM K06937 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 421.0
TLS2_k127_7300782_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.0000000000000000001415 91.0
TLS2_k127_7358584_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007269 511.0
TLS2_k127_7358584_1 Required for morphogenesis under gluconeogenic growth conditions - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 355.0
TLS2_k127_7358584_2 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000968 238.0
TLS2_k127_7358584_3 May be required for sporulation K09762 - - 0.0000000000000000000000000003622 131.0
TLS2_k127_745339_0 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008813 331.0
TLS2_k127_745339_1 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000004455 227.0
TLS2_k127_745339_2 PFAM AMP-dependent synthetase and ligase - - - 0.00000000000000000000000000000000000000000000000001907 208.0
TLS2_k127_745339_3 Forkhead associated domain - - - 0.00000000000000000000000000000000000000000000006135 190.0
TLS2_k127_745339_4 ABC-2 family transporter protein - - - 0.0000000000000000000000000000005266 140.0
TLS2_k127_745339_5 PFAM conserved - - - 0.0000000000000000000000007548 114.0
TLS2_k127_745339_6 translation initiation factor activity - - - 0.00000000000002018 83.0
TLS2_k127_7461000_0 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 461.0
TLS2_k127_7461000_1 PFAM peptidase M24 K01262,K01271,K01274 - 3.4.11.9,3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007249 368.0
TLS2_k127_7461000_2 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000007817 158.0
TLS2_k127_7461000_3 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000009548 164.0
TLS2_k127_7461000_4 Helix-turn-helix domain - - - 0.000000000000000000000000000002293 128.0
TLS2_k127_7461000_5 Transmembrane secretion effector - - - 0.00000000000000000000000007581 119.0
TLS2_k127_7461000_6 PFAM Phospholipid glycerol acyltransferase - - - 0.000000000000000003707 99.0
TLS2_k127_7461000_7 - - - - 0.0000008957 58.0
TLS2_k127_771895_0 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007182 435.0
TLS2_k127_771895_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 441.0
TLS2_k127_771895_10 PFAM single-strand binding protein Primosomal replication protein n K03111 - - 0.000000000000000000000000000003892 124.0
TLS2_k127_771895_2 Belongs to the ABC transporter superfamily K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 394.0
TLS2_k127_771895_3 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 349.0
TLS2_k127_771895_4 extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 354.0
TLS2_k127_771895_5 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002413 286.0
TLS2_k127_771895_6 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000001689 277.0
TLS2_k127_771895_7 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000279 245.0
TLS2_k127_771895_8 TIGRFAM hydrolase, TatD family K03424 - - 0.000000000000000000000000000000000000000000000000000000002422 215.0
TLS2_k127_771895_9 Oxidoreductase FAD-binding domain - - - 0.00000000000000000000000000000007694 134.0
TLS2_k127_802043_0 helicase superfamily c-terminal domain K06877 - - 2.765e-276 872.0
TLS2_k127_802043_1 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 4.35e-254 817.0
TLS2_k127_802043_10 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000006489 162.0
TLS2_k127_802043_11 RNase_H superfamily K07502 - - 0.0000000000000000000000000000000001758 153.0
TLS2_k127_802043_12 Methyltransferase domain - - - 0.0000000000000000006715 100.0
TLS2_k127_802043_13 pfkB family carbohydrate kinase K00852 - 2.7.1.15 0.0001577 53.0
TLS2_k127_802043_2 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005613 597.0
TLS2_k127_802043_3 Family 4 glycosyl hydrolase K01222,K07406 - 3.2.1.22,3.2.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008077 540.0
TLS2_k127_802043_4 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 359.0
TLS2_k127_802043_5 Zincin-like metallopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002196 290.0
TLS2_k127_802043_6 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001939 283.0
TLS2_k127_802043_7 Asp/Glu/Hydantoin racemase K01776,K02428 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 3.6.1.66,5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000002413 234.0
TLS2_k127_802043_8 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002188 235.0
TLS2_k127_802043_9 N-acetylglucosamine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000003224 234.0
TLS2_k127_896304_0 Peptidase family S58 K01266 - 3.4.11.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 441.0
TLS2_k127_896304_1 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007004 383.0
TLS2_k127_896304_10 Protein of unknown function (DUF1761) - - - 0.00000000001427 72.0
TLS2_k127_896304_2 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008929 358.0
TLS2_k127_896304_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 304.0
TLS2_k127_896304_5 Radical SAM superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000009984 233.0
TLS2_k127_896304_6 Thioesterase superfamily - - - 0.000000000000000000000000000000000000001808 150.0
TLS2_k127_896304_7 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000008475 144.0
TLS2_k127_896304_8 EamA-like transporter family - - - 0.00000000000000000000000000000006779 136.0
TLS2_k127_896304_9 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000000000007685 133.0
TLS2_k127_921456_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 441.0
TLS2_k127_921456_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000002815 267.0
TLS2_k127_938644_0 PFAM major facilitator superfamily MFS_1 K08167 - - 3.321e-201 635.0
TLS2_k127_938644_1 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 456.0
TLS2_k127_97002_0 PFAM Acetyl-CoA hydrolase transferase K01067 - 3.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007523 502.0
TLS2_k127_97002_1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005633 446.0
TLS2_k127_97002_2 Multicopper oxidase K22348 - 1.16.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004261 293.0
TLS2_k127_97002_3 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000000000000000000000000000000000003224 182.0
TLS2_k127_97002_4 Cbs domain - - - 0.00000000000000000000000000000000000000006355 162.0
TLS2_k127_97002_5 COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms - - - 0.0000000000000000000000000000003599 134.0
TLS2_k127_97002_6 PFAM CBS domain K07182 - - 0.00000000000000000000002404 104.0
TLS2_k127_97002_7 Belongs to the universal stress protein A family - - - 0.00000000000000000442 94.0
TLS2_k127_984037_0 PFAM Endonuclease exonuclease phosphatase K07004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008579 634.0
TLS2_k127_984037_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 369.0
TLS2_k127_984037_2 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 303.0
TLS2_k127_984037_3 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002102 248.0
TLS2_k127_984037_4 PFAM UbiA prenyltransferase K02548 - 2.5.1.74 0.00000000000000000000000000000000000001073 163.0
TLS2_k127_984037_6 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000000001298 96.0
TLS2_k127_984037_7 coenzyme F420 binding - - - 0.0000000003406 67.0