logo

Overview

ID MAG03989
Name TLS2_bin.21
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Vicinamibacteria
Order Vicinamibacterales
Family UBA2999
Genus
Species
Assembly information
Completeness (%) 96.66
Contamination (%) 5.75
GC content (%) 71.0
N50 (bp) 15,841
Genome size (bp) 5,643,132

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes4536

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1010558_0 and related - - - 1.351e-200 635.0
TLS2_k127_1010558_1 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 571.0
TLS2_k127_1010558_2 cytochrome p450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 524.0
TLS2_k127_1010558_3 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009717 451.0
TLS2_k127_1010558_4 Intracellular protease, PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003344 269.0
TLS2_k127_1010558_5 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004262 276.0
TLS2_k127_1010558_6 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000003388 147.0
TLS2_k127_1010558_7 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000006624 122.0
TLS2_k127_1010558_8 PRC-barrel domain - - - 0.0000000000000000008597 99.0
TLS2_k127_1010558_9 lyase activity - - - 0.0000000000007489 78.0
TLS2_k127_101429_0 DNA polymerase X K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007762 565.0
TLS2_k127_101429_1 Mur ligase middle domain K02558 - 6.3.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007061 434.0
TLS2_k127_101429_2 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 307.0
TLS2_k127_101429_3 Phosphate-selective porin O and P - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002032 288.0
TLS2_k127_101429_4 LD-carboxypeptidase K01297 - 3.4.17.13 0.000000000000000000000000000000000000000000000000000000001118 216.0
TLS2_k127_101429_5 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000002021 153.0
TLS2_k127_101429_6 - - - - 0.0000000000000000000000000354 117.0
TLS2_k127_101429_7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000002201 103.0
TLS2_k127_101429_8 Helix-turn-helix domain K15539 - - 0.000000000000256 77.0
TLS2_k127_1015232_0 Domain of unknown function (DUF5107) - - - 1.536e-236 772.0
TLS2_k127_1015232_1 metal ion transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000859 494.0
TLS2_k127_1015232_2 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 357.0
TLS2_k127_1015232_3 Periplasmic binding protein domain K10439 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 319.0
TLS2_k127_1015232_4 KR domain K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 320.0
TLS2_k127_1015232_5 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005456 331.0
TLS2_k127_1015232_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000021 288.0
TLS2_k127_1015232_7 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000043 257.0
TLS2_k127_1015232_8 - - - - 0.000000000000000000000001114 117.0
TLS2_k127_1015232_9 Subtilisin inhibitor-like - - - 0.000000000000000000000219 109.0
TLS2_k127_1020632_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002912 302.0
TLS2_k127_1020632_1 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 307.0
TLS2_k127_1020632_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000155 240.0
TLS2_k127_1020632_3 - - - - 0.00000000000000000000000000000000000000000000000000000001392 222.0
TLS2_k127_1020632_4 - - - - 0.000000000000000000000000000000000000000001486 177.0
TLS2_k127_1021939_0 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 301.0
TLS2_k127_1021939_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004896 253.0
TLS2_k127_1021939_2 Protein involved in cellulose biosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000000003149 228.0
TLS2_k127_1021939_3 Sulfotransferase family K20444 - - 0.00000000000000000000000000000000000000000000000000000000000117 227.0
TLS2_k127_1021939_4 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000003579 177.0
TLS2_k127_1021939_5 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000001387 174.0
TLS2_k127_1021939_6 Methyltransferase domain - - - 0.000000000000000000000000001855 124.0
TLS2_k127_1021939_7 - - - - 0.0000000000001157 85.0
TLS2_k127_1021939_8 Polysaccharide biosynthesis C-terminal domain - - - 0.000000000004461 80.0
TLS2_k127_1021939_9 Phosphotransferase enzyme family - - - 0.000000212 57.0
TLS2_k127_1023390_0 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 406.0
TLS2_k127_1023390_1 Polycystin cation channel K08714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000269 276.0
TLS2_k127_1023390_2 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000002293 140.0
TLS2_k127_1023390_3 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.00000000000000000000000001229 116.0
TLS2_k127_1028274_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 1.423e-236 751.0
TLS2_k127_1028274_1 ABC transporter C-terminal domain K06158 - - 2.806e-202 651.0
TLS2_k127_1028274_10 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000002382 240.0
TLS2_k127_1028274_11 PFAM ATP-binding region, ATPase domain protein K02668,K07708,K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000002234 218.0
TLS2_k127_1028274_12 surface antigen variable number - - - 0.0000000000000000000000000000000000000000000000001291 205.0
TLS2_k127_1028274_13 pilus organization K07346 - - 0.00000000000000000000000000000000000000000000001876 183.0
TLS2_k127_1028274_14 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000001273 134.0
TLS2_k127_1028274_15 Spore Coat Protein U domain - - - 0.000000000000000000000000002349 117.0
TLS2_k127_1028274_16 Spore Coat Protein U domain - - - 0.0000000000000000000000001005 113.0
TLS2_k127_1028274_17 Biotin-requiring enzyme - - - 0.000000000000000000000007984 113.0
TLS2_k127_1028274_18 Fibronectin type 3 domain - - - 0.0000000000006185 82.0
TLS2_k127_1028274_2 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 2.597e-195 622.0
TLS2_k127_1028274_20 AntiSigma factor - - - 0.0008715 51.0
TLS2_k127_1028274_3 Carbamoyl-phosphate synthetase large chain domain protein K01961,K01968,K11263 - 6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009615 484.0
TLS2_k127_1028274_4 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008816 423.0
TLS2_k127_1028274_5 Outer membrane usher protein K07347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 425.0
TLS2_k127_1028274_6 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008136 330.0
TLS2_k127_1028274_7 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 290.0
TLS2_k127_1028274_8 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 325.0
TLS2_k127_1028274_9 fumarylacetoacetate (FAA) hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001433 258.0
TLS2_k127_1031927_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 3.244e-284 884.0
TLS2_k127_1031927_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147,K22465 - 4.1.99.17,4.1.99.23 2.69e-272 851.0
TLS2_k127_1031927_10 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000004575 210.0
TLS2_k127_1031927_11 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000003892 196.0
TLS2_k127_1031927_12 Formiminotransferase-cyclodeaminase - - - 0.000000000000000000000000000001141 130.0
TLS2_k127_1031927_13 DivIVA protein K04074 - - 0.000000000000000000000003229 111.0
TLS2_k127_1031927_14 Belongs to the UPF0235 family K09131 - - 0.0000000000000007782 83.0
TLS2_k127_1031927_15 ASPIC and UnbV - - - 0.0000007801 61.0
TLS2_k127_1031927_16 TonB dependent receptor - - - 0.00004138 55.0
TLS2_k127_1031927_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 571.0
TLS2_k127_1031927_3 HELICc2 K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007844 547.0
TLS2_k127_1031927_4 Belongs to the ClpA ClpB family K03695,K03696 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 405.0
TLS2_k127_1031927_5 Methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008636 381.0
TLS2_k127_1031927_6 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 341.0
TLS2_k127_1031927_7 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004491 344.0
TLS2_k127_1031927_8 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 310.0
TLS2_k127_1031927_9 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000009647 220.0
TLS2_k127_103784_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 533.0
TLS2_k127_103784_1 Belongs to the peptidase M16 family - - - 0.000000000000000000008799 93.0
TLS2_k127_103784_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000007834 58.0
TLS2_k127_1048603_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 482.0
TLS2_k127_1048603_1 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000001585 126.0
TLS2_k127_1051089_0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 462.0
TLS2_k127_1051089_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003247 448.0
TLS2_k127_1052319_0 negative regulation of protein lipidation K19294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004566 586.0
TLS2_k127_1052319_1 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008938 585.0
TLS2_k127_1052319_2 FAD dependent oxidoreductase K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009785 400.0
TLS2_k127_1052319_3 PFAM Glycosyl transferase family 2 K10012 - 2.4.2.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 369.0
TLS2_k127_1052319_4 SGNH hydrolase-like domain, acetyltransferase AlgX K19295 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009288 300.0
TLS2_k127_1052319_5 O-acyltransferase activity K00633 - 2.3.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000002831 259.0
TLS2_k127_1052319_6 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000324 143.0
TLS2_k127_1052319_7 Glycosyltransferase like family 2 - - - 0.0000000000000000000000001058 124.0
TLS2_k127_1052319_8 PFAM SNARE associated Golgi protein - - - 0.000000000000000000001905 102.0
TLS2_k127_1052319_9 Carbohydrate-binding protein of the ER - - - 0.0000005898 53.0
TLS2_k127_1054978_0 peptidyl-tyrosine sulfation - - - 2.807e-198 652.0
TLS2_k127_1054978_1 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 631.0
TLS2_k127_1054978_10 TonB dependent receptor - - - 0.00000000000000000000000000001213 126.0
TLS2_k127_1054978_11 TonB dependent receptor - - - 0.00000000000000000000001238 105.0
TLS2_k127_1054978_12 TonB dependent receptor - - - 0.000000000000000000006397 98.0
TLS2_k127_1054978_13 Tetratricopeptide repeat - - - 0.00000000000000006702 94.0
TLS2_k127_1054978_2 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008849 554.0
TLS2_k127_1054978_3 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 510.0
TLS2_k127_1054978_4 cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 472.0
TLS2_k127_1054978_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 347.0
TLS2_k127_1054978_6 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000003008 265.0
TLS2_k127_1054978_7 Trehalose utilisation - - - 0.00000000000000000000000000000000000000000000000000000000000007658 229.0
TLS2_k127_1054978_8 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000009332 185.0
TLS2_k127_1054978_9 Haem-degrading K11477 - - 0.0000000000000000000000000000001088 134.0
TLS2_k127_1063323_0 SMART Phospholipid glycerol acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 404.0
TLS2_k127_1063323_1 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 342.0
TLS2_k127_1063323_2 - - - - 0.0000000000000000000000000007434 125.0
TLS2_k127_1063323_3 DinB family - - - 0.00000000000000000000325 105.0
TLS2_k127_1063323_4 YHS domain protein - - - 0.0000000000000000000829 96.0
TLS2_k127_1067868_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 613.0
TLS2_k127_1067868_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 382.0
TLS2_k127_1067868_10 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000005891 166.0
TLS2_k127_1067868_11 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000009322 130.0
TLS2_k127_1067868_12 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) K00878 - 2.7.1.50 0.0000000000000000000000000000001319 131.0
TLS2_k127_1067868_13 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000000000000000000000000007035 134.0
TLS2_k127_1067868_14 Pilus assembly protein, PilO K02664 - - 0.00000000000000000007198 97.0
TLS2_k127_1067868_15 Tetratricopeptide repeats - - - 0.00000000000001588 81.0
TLS2_k127_1067868_17 Pilus assembly protein, PilP K02665 - - 0.0000009389 61.0
TLS2_k127_1067868_18 PFAM Fimbrial assembly family protein K02663 - - 0.00003943 55.0
TLS2_k127_1067868_2 Secretin and TonB N terminus short domain K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 368.0
TLS2_k127_1067868_3 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005812 336.0
TLS2_k127_1067868_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007914 333.0
TLS2_k127_1067868_5 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 319.0
TLS2_k127_1067868_6 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - 0.0000000000000000000000000000000000000000000000000000000000000000000001279 250.0
TLS2_k127_1067868_7 PFAM peptidase M24 K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000001655 253.0
TLS2_k127_1067868_8 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000009773 206.0
TLS2_k127_1067868_9 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000463 186.0
TLS2_k127_1073105_0 adenylyl cyclase class-3 4 guanylyl cyclase - - - 9.159e-266 856.0
TLS2_k127_1073105_1 DNA methylAse K07445 - - 0.0000000000000003647 83.0
TLS2_k127_107650_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1046.0
TLS2_k127_107650_1 Methyltransferase domain - - - 0.00000000003717 72.0
TLS2_k127_1076550_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14387 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004708 420.0
TLS2_k127_1076550_1 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000000000000000000005772 117.0
TLS2_k127_1082355_0 GMC oxidoreductase - - - 1.825e-236 742.0
TLS2_k127_1082355_1 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 1.957e-231 729.0
TLS2_k127_1082355_10 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 329.0
TLS2_k127_1082355_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000155 227.0
TLS2_k127_1082355_12 Ferredoxin K04755 - - 0.000000000000000000000000000000000000000000000000000009198 190.0
TLS2_k127_1082355_13 PFAM cytochrome P450 - - - 0.00000000000000000000000000000000004809 141.0
TLS2_k127_1082355_14 YCII-related domain - - - 0.000000000000000000000000000000003075 132.0
TLS2_k127_1082355_15 - - - - 0.000000000000000006621 89.0
TLS2_k127_1082355_16 PFAM PIN domain - - - 0.000000001229 68.0
TLS2_k127_1082355_2 Putative esterase K07214 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 605.0
TLS2_k127_1082355_3 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 526.0
TLS2_k127_1082355_4 PFAM LOR SDH bifunctional enzyme conserved region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007237 516.0
TLS2_k127_1082355_5 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005222 461.0
TLS2_k127_1082355_6 MreB/Mbl protein K03569 GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 436.0
TLS2_k127_1082355_7 Bacterial protein of unknown function (DUF899) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 381.0
TLS2_k127_1082355_8 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 336.0
TLS2_k127_1082355_9 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 321.0
TLS2_k127_1084583_0 Nodulation protein S (NodS) - - - 0.000000000003757 79.0
TLS2_k127_109468_0 Belongs to the type-B carboxylesterase lipase family K03929 - - 6.607e-212 692.0
TLS2_k127_109468_1 Putative esterase K07214 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006869 569.0
TLS2_k127_109468_2 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000524 437.0
TLS2_k127_109468_3 DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 311.0
TLS2_k127_109468_4 Protein of unknown function (DUF4256) - - - 0.000000000000000000000000000000000000000000000000000000000001787 209.0
TLS2_k127_109468_5 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000003979 181.0
TLS2_k127_109468_6 Antitoxin component of a toxin-antitoxin (TA) module - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.000000001425 63.0
TLS2_k127_109468_7 PIN domain - - - 0.0000001733 59.0
TLS2_k127_1097871_0 metallocarboxypeptidase activity K14054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004796 580.0
TLS2_k127_1097871_1 metal-dependent hydrolase with the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 509.0
TLS2_k127_1097871_10 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.0000000000003575 83.0
TLS2_k127_1097871_11 lyase activity - - - 0.0000005342 64.0
TLS2_k127_1097871_12 CsbD-like - - - 0.000007459 53.0
TLS2_k127_1097871_13 Putative zinc-finger - - - 0.0001428 53.0
TLS2_k127_1097871_2 Na dependent nucleoside K03317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005847 415.0
TLS2_k127_1097871_3 TIGRFAM Pyrimidine-nucleoside phosphorylase K00756,K00758 - 2.4.2.2,2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 426.0
TLS2_k127_1097871_4 PFAM RNA-binding protein AU-1 Ribonuclease E G K08301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007614 374.0
TLS2_k127_1097871_5 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 333.0
TLS2_k127_1097871_6 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.000000000000000000000000000000000000000000000000000000001188 222.0
TLS2_k127_1097871_7 SMP-30/Gluconolaconase/LRE-like region - - - 0.0000000000000000000000000000000000000000000000001896 184.0
TLS2_k127_1097871_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000005569 162.0
TLS2_k127_1097871_9 Putative adhesin - - - 0.0000000000000000000000000007333 126.0
TLS2_k127_1098281_0 cheY-homologous receiver domain - - - 0.0000000000000000000001419 102.0
TLS2_k127_1098281_1 lyase activity - - - 0.000001747 61.0
TLS2_k127_1102463_0 protein-glutamate methylesterase K00575,K13924 - 2.1.1.80,3.1.1.61 2.963e-245 803.0
TLS2_k127_1102463_1 Belongs to the 5'-nucleotidase family - - - 5.738e-212 668.0
TLS2_k127_1102463_10 WD-40 repeat - - - 0.00000000000000000000000000000000000000000000000016 196.0
TLS2_k127_1102463_11 Integrase core domain - - - 0.0000000000000000000000000000000000000000000003027 174.0
TLS2_k127_1102463_12 - - - - 0.000000000000000005289 98.0
TLS2_k127_1102463_13 - - - - 0.00000000000000005934 85.0
TLS2_k127_1102463_15 Lactonase, 7-bladed beta-propeller - - - 0.0000000006636 68.0
TLS2_k127_1102463_16 Transcriptional regulator K07726 - - 0.00000001249 57.0
TLS2_k127_1102463_17 Protein of unknown function (DUF433) - - - 0.00000001634 57.0
TLS2_k127_1102463_18 HicA toxin of bacterial toxin-antitoxin, - - - 0.00001094 49.0
TLS2_k127_1102463_2 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 583.0
TLS2_k127_1102463_3 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007581 471.0
TLS2_k127_1102463_4 Hemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 412.0
TLS2_k127_1102463_5 Phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 379.0
TLS2_k127_1102463_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 322.0
TLS2_k127_1102463_7 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001617 258.0
TLS2_k127_1102463_8 Phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001598 244.0
TLS2_k127_1102463_9 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000003011 215.0
TLS2_k127_1103429_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 2282.0
TLS2_k127_1103429_1 Hep Hag repeat protein K01179,K01207 - 3.2.1.4,3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 418.0
TLS2_k127_1103429_2 alginic acid biosynthetic process K01729 - 4.2.2.3 0.0000000000000000000000000000000000000000000000000000000000000004379 250.0
TLS2_k127_1103429_3 SNF2 family N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000004038 230.0
TLS2_k127_1103429_4 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.0000000001067 67.0
TLS2_k127_1103429_5 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000001625 70.0
TLS2_k127_1103467_0 UPF0365 protein - - - 0.00000000000000000000000000000000000002868 145.0
TLS2_k127_1103467_1 His Kinase A (phospho-acceptor) domain - - - 0.00000000000000000000000000000000000003101 146.0
TLS2_k127_1103467_2 Thiol disulfide interchange protein K04084 - 1.8.1.8 0.00000000000000000000000000000000001303 140.0
TLS2_k127_1103467_3 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000000001095 145.0
TLS2_k127_1103467_4 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000008812 106.0
TLS2_k127_1103467_5 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000004231 91.0
TLS2_k127_1117178_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 545.0
TLS2_k127_1117178_1 PFAM Glycosyl transferase, group 1 K00754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 387.0
TLS2_k127_1117178_2 PFAM tRNA rRNA methyltransferase (SpoU) - - - 0.0000000000000000000000000000000000000000000000000000001323 207.0
TLS2_k127_1117178_3 PFAM Diacylglycerol kinase, catalytic K07029 - 2.7.1.107 0.000000000000000000000000002064 124.0
TLS2_k127_1117178_4 PFAM LmbE family protein K01463 - - 0.000000000005269 70.0
TLS2_k127_112244_0 candidate b-glycosidase, glycoside hydrolase family 8 protein - - - 0.000000000000000000000000000000000000000000000000000000000001448 239.0
TLS2_k127_112244_1 Acyltransferase family - - - 0.000002312 59.0
TLS2_k127_1130724_0 CoA enzyme activase uncharacterised domain (DUF2229) - - - 0.0 1157.0
TLS2_k127_1130724_1 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 502.0
TLS2_k127_1130724_2 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 351.0
TLS2_k127_1130724_3 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000473 295.0
TLS2_k127_1130724_4 carboxylic acid catabolic process K01684 - 4.2.1.6 0.00000000000000000000000000000000001802 138.0
TLS2_k127_1134341_0 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005338 338.0
TLS2_k127_1134341_1 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006749 296.0
TLS2_k127_1134341_2 Trypsin-like serine protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004565 288.0
TLS2_k127_1134341_3 COG1404 Subtilisin-like serine proteases - - - 0.00000000000001132 88.0
TLS2_k127_1134341_4 PKD domain - - - 0.00000004894 66.0
TLS2_k127_1141172_0 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 400.0
TLS2_k127_1141172_1 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000004446 246.0
TLS2_k127_1141172_2 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000001079 134.0
TLS2_k127_1164864_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 9.481e-301 955.0
TLS2_k127_1164864_1 COG2706 3-carboxymuconate cyclase K07404 - 3.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000673 373.0
TLS2_k127_1164864_2 response regulator receiver K02483,K07658,K07668 - - 0.0000000000000000000000000000000000000000000000000000000000002462 220.0
TLS2_k127_1164864_3 Histidine kinase K07642 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000001582 220.0
TLS2_k127_1164864_4 phosphorelay sensor kinase activity K03406,K07675,K17763 - 2.7.13.3 0.00000000002362 76.0
TLS2_k127_1164864_5 ATP-independent chaperone mediated protein folding K06006 - - 0.0000008806 61.0
TLS2_k127_1172955_0 C-terminal, D2-small domain, of ClpB protein K03694 - - 1.005e-241 773.0
TLS2_k127_1172955_1 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 1.605e-220 701.0
TLS2_k127_1172955_10 efflux transmembrane transporter activity - - - 0.0000000000000000000000003177 122.0
TLS2_k127_1172955_11 - - - - 0.000000000000000000000007886 109.0
TLS2_k127_1172955_12 Helix-turn-helix domain K15539 - - 0.00000000000000000000003622 109.0
TLS2_k127_1172955_2 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005445 554.0
TLS2_k127_1172955_3 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 507.0
TLS2_k127_1172955_4 ATPase activity K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003689 274.0
TLS2_k127_1172955_5 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000000000000000006072 252.0
TLS2_k127_1172955_6 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000001123 213.0
TLS2_k127_1172955_7 DinB family - - - 0.0000000000000000000000000000000000000000000000001114 183.0
TLS2_k127_1172955_8 Aminotransferase class-III K15372 - 2.6.1.55 0.000000000000000000000000000002429 126.0
TLS2_k127_1172955_9 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000002593 117.0
TLS2_k127_1179396_0 Peptidase M16 - - - 0.0 1052.0
TLS2_k127_1179396_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.0000000000000000000000000000007812 123.0
TLS2_k127_1179396_2 Histidine kinase - - - 0.000000000003896 71.0
TLS2_k127_1185520_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1091.0
TLS2_k127_1185520_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1026.0
TLS2_k127_1185520_10 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 366.0
TLS2_k127_1185520_11 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004023 349.0
TLS2_k127_1185520_12 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003783 286.0
TLS2_k127_1185520_13 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007211 292.0
TLS2_k127_1185520_14 PFAM Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007279 300.0
TLS2_k127_1185520_15 PFAM Phosphomethylpyrimidine kinase type-1 K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007038 276.0
TLS2_k127_1185520_16 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008381 279.0
TLS2_k127_1185520_17 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000002477 266.0
TLS2_k127_1185520_18 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007653 246.0
TLS2_k127_1185520_19 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000003239 241.0
TLS2_k127_1185520_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.178e-279 882.0
TLS2_k127_1185520_20 MotA TolQ ExbB proton channel K03561,K03562 - - 0.00000000000000000000000000000000000000000000000000000000000001799 222.0
TLS2_k127_1185520_21 Deoxynucleoside kinase K15518 - 2.7.1.113 0.0000000000000000000000000000000000000000000000000000000000003735 218.0
TLS2_k127_1185520_22 DNA polymerase alpha chain like domain K07053,K20859 - 3.1.3.97,3.1.4.57 0.0000000000000000000000000000000000000000000000000000000002343 212.0
TLS2_k127_1185520_23 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000005601 226.0
TLS2_k127_1185520_24 Putative RNA methylase family UPF0020 K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000007015 184.0
TLS2_k127_1185520_25 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000002495 158.0
TLS2_k127_1185520_26 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000003716 162.0
TLS2_k127_1185520_27 PFAM Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000000000004328 169.0
TLS2_k127_1185520_28 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000000000000000000000000000003581 161.0
TLS2_k127_1185520_29 Copper/zinc superoxide dismutase (SODC) K04565 - 1.15.1.1 0.0000000000000000000000000000000000000003257 156.0
TLS2_k127_1185520_3 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 4.596e-251 793.0
TLS2_k127_1185520_30 MoaE protein K21142 - 2.8.1.12 0.0000000000000000000000000000000000000003792 158.0
TLS2_k127_1185520_31 BioY family K03523 - - 0.000000000000000000000000000000000000002682 155.0
TLS2_k127_1185520_32 Methyltransferase domain - - - 0.00000000000000000000000000000000000000353 158.0
TLS2_k127_1185520_33 - - - - 0.000000000000000000000000000000001153 138.0
TLS2_k127_1185520_34 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000000002701 131.0
TLS2_k127_1185520_35 Signal peptidase (SPase) II K03101 - 3.4.23.36 0.000000000000000000000000000000268 129.0
TLS2_k127_1185520_36 PFAM NUDIX hydrolase K01515 - 3.6.1.13 0.0000000000000000000000000001385 125.0
TLS2_k127_1185520_37 Belongs to the Fur family K03711 - - 0.00000000000000000000000002286 122.0
TLS2_k127_1185520_38 Curli production assembly/transport component CsgG - - - 0.0000000000000000000000000833 121.0
TLS2_k127_1185520_39 Biopolymer transport protein ExbD/TolR K03560 - - 0.000000000000000000000003781 108.0
TLS2_k127_1185520_4 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 1.254e-228 718.0
TLS2_k127_1185520_40 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.0000000000000000000002537 102.0
TLS2_k127_1185520_41 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000002585 92.0
TLS2_k127_1185520_42 Necessary for formate dehydrogenase activity K02380 - - 0.0000000000000000002135 99.0
TLS2_k127_1185520_43 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000002949 84.0
TLS2_k127_1185520_44 PFAM Haloacid dehalogenase domain protein hydrolase K07025 - - 0.000000000000003077 88.0
TLS2_k127_1185520_45 Preprotein translocase subunit K03210 - - 0.000000000000009873 80.0
TLS2_k127_1185520_46 - - - - 0.00000000000003301 81.0
TLS2_k127_1185520_47 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 0.0000000000003743 82.0
TLS2_k127_1185520_48 MoaE protein K03635,K03636,K03637,K03752,K21142 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.7.7.77,2.8.1.12,4.6.1.17 0.000000000001354 76.0
TLS2_k127_1185520_49 PFAM Forkhead-associated protein - - - 0.0000000000186 76.0
TLS2_k127_1185520_5 Fumarase C C-terminus K01744 - 4.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 500.0
TLS2_k127_1185520_50 repeat-containing protein - - - 0.000000007451 67.0
TLS2_k127_1185520_51 PFAM Rubrerythrin - - - 0.000002167 59.0
TLS2_k127_1185520_52 - - - - 0.000004451 57.0
TLS2_k127_1185520_53 Organic solvent tolerance protein K04744 - - 0.00007083 53.0
TLS2_k127_1185520_6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003611 461.0
TLS2_k127_1185520_7 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 451.0
TLS2_k127_1185520_8 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 437.0
TLS2_k127_1185520_9 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 395.0
TLS2_k127_1221534_0 AAA domain - - - 3.627e-311 994.0
TLS2_k127_1221534_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006167 569.0
TLS2_k127_1221534_10 helicase superfamily c-terminal domain K03724 - - 0.0002688 47.0
TLS2_k127_1221534_11 PFAM Stage II sporulation E family protein K07315 - 3.1.3.3 0.0007 43.0
TLS2_k127_1221534_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 424.0
TLS2_k127_1221534_3 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001911 247.0
TLS2_k127_1221534_4 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000002691 221.0
TLS2_k127_1221534_5 light absorption K06893 - - 0.0000000000000000000000000000000000000000000000000000000000002567 217.0
TLS2_k127_1221534_6 PFAM Stage II sporulation protein E (SpoIIE) - - - 0.000000000000000000000000000000000000000000000000000000000006199 223.0
TLS2_k127_1221534_7 ribonuclease activity - - - 0.000000000000000000000000000000001235 136.0
TLS2_k127_1221534_8 Putative restriction endonuclease - - - 0.000000000000000000005806 104.0
TLS2_k127_1221534_9 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000000007153 94.0
TLS2_k127_1225713_0 Belongs to the DEAD box helicase family K05592,K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 1.108e-204 651.0
TLS2_k127_1225713_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 456.0
TLS2_k127_1225713_10 Domain of Unknown Function (DUF1206) - - - 0.0000000000000000000000000000000000000000008514 169.0
TLS2_k127_1225713_11 membrane - - - 0.0000000000000000000000000000000000000002211 155.0
TLS2_k127_1225713_12 Alpha beta hydrolase fold-3 domain protein - - - 0.0000000000000000000000000000000000005123 151.0
TLS2_k127_1225713_13 - - - - 0.0000000000000000000000000000003932 126.0
TLS2_k127_1225713_14 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.0000000001558 63.0
TLS2_k127_1225713_15 single-stranded DNA 5'-3' exodeoxyribonuclease activity K07462 - - 0.00002211 54.0
TLS2_k127_1225713_2 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 363.0
TLS2_k127_1225713_3 geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 341.0
TLS2_k127_1225713_4 Glyoxalase-like domain K07032 - - 0.000000000000000000000000000000000000000000000000000000000000001525 232.0
TLS2_k127_1225713_5 UV-endonuclease UvdE K13281 - - 0.0000000000000000000000000000000000000000000000000000000000001395 241.0
TLS2_k127_1225713_6 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000002709 215.0
TLS2_k127_1225713_7 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000000001438 207.0
TLS2_k127_1225713_8 OsmC-like protein K07397 - - 0.000000000000000000000000000000000000000000000003071 183.0
TLS2_k127_1225713_9 DoxX-like family - - - 0.0000000000000000000000000000000000000000004511 162.0
TLS2_k127_1227139_0 Putative outer membrane beta-barrel porin, MtrB/PioB K22110 - - 0.000000000000000000003579 106.0
TLS2_k127_1254986_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 610.0
TLS2_k127_1254986_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 554.0
TLS2_k127_1254986_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 510.0
TLS2_k127_1254986_3 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 481.0
TLS2_k127_1254986_4 Phosphoglycerate mutase family K01834 - 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005732 391.0
TLS2_k127_1274557_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004313 410.0
TLS2_k127_1274557_1 PFAM aromatic-ring-hydroxylating dioxygenase, beta subunit - - - 0.00000000000000000000000000000000000000000000000000000002257 201.0
TLS2_k127_1274557_2 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.000000004499 61.0
TLS2_k127_1305161_0 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008717 503.0
TLS2_k127_1305161_1 Protein of unknown function (DUF4256) - - - 0.00000000000000000000000000000000000000000000000000001302 191.0
TLS2_k127_1315604_0 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 517.0
TLS2_k127_1315604_1 dehydrogenases and related proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004165 483.0
TLS2_k127_1315604_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 400.0
TLS2_k127_1315604_3 Maltose acetyltransferase K00661 - 2.3.1.79 0.0000000000000000000000000000000000000000000000322 170.0
TLS2_k127_1316808_0 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000002102 170.0
TLS2_k127_1316808_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000001129 102.0
TLS2_k127_1316808_2 protein kinase activity - - - 0.000002252 57.0
TLS2_k127_1342564_0 cobalamin binding K01647,K18997,K22491 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000001083 198.0
TLS2_k127_1342564_1 Domain of unknown function (DUF296) K06934 - - 0.0000000000000000000000000000000000000000000002289 171.0
TLS2_k127_1342564_2 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000000004986 165.0
TLS2_k127_1342564_3 PFAM Fasciclin domain K19519 - - 0.0000000000000000001202 97.0
TLS2_k127_1342564_4 cytochrome o ubiquinol oxidase K03975 - - 0.000001136 53.0
TLS2_k127_1351614_0 Cytochrome c - - - 3.984e-288 914.0
TLS2_k127_1351614_1 PQQ enzyme repeat K00117 - 1.1.5.2 2.275e-252 796.0
TLS2_k127_1351614_10 hexulose-6-phosphate isomerase K03079 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019324,GO:0019752,GO:0019852,GO:0034015,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0051186,GO:0071704 5.1.3.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008044 339.0
TLS2_k127_1351614_11 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 322.0
TLS2_k127_1351614_12 TIM-barrel enzyme, possibly a dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 288.0
TLS2_k127_1351614_13 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001105 280.0
TLS2_k127_1351614_14 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000002965 241.0
TLS2_k127_1351614_15 Serine hydrolase (FSH1) K06889 - - 0.000000000000000000000000000000000000000000000000000004288 201.0
TLS2_k127_1351614_16 BON domain - - - 0.000000000000000000168 100.0
TLS2_k127_1351614_17 Salt-induced outer membrane protein K07283 - - 0.000000000001901 80.0
TLS2_k127_1351614_2 protein import - - - 1.551e-241 784.0
TLS2_k127_1351614_3 hydrolase activity, hydrolyzing O-glycosyl compounds K01176,K22253 - 3.2.1.1,3.2.1.60 5.049e-226 711.0
TLS2_k127_1351614_4 Major facilitator superfamily - - - 5.132e-223 706.0
TLS2_k127_1351614_5 Protein of unknown function (DUF1501) - - - 7.213e-210 697.0
TLS2_k127_1351614_6 Cytochrome c - - - 1.831e-194 627.0
TLS2_k127_1351614_7 dehydrogenases and related proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 422.0
TLS2_k127_1351614_8 Uncharacterised protein family (UPF0261) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 391.0
TLS2_k127_1351614_9 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006724 387.0
TLS2_k127_135190_0 Belongs to the ClpA ClpB family K03694,K03695 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 3.585e-220 694.0
TLS2_k127_135190_1 DnaJ molecular chaperone homology domain K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 334.0
TLS2_k127_135190_2 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000006168 195.0
TLS2_k127_135190_3 helix_turn_helix, mercury resistance K13640 - - 0.0000000000000000000004713 100.0
TLS2_k127_1352416_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0004353 51.0
TLS2_k127_1358078_0 Beta-galactosidase trimerisation domain K12308 - 3.2.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006553 541.0
TLS2_k127_1358078_1 Oxidoreductase family, C-terminal alpha beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004412 527.0
TLS2_k127_1358078_2 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 0.000000000000411 72.0
TLS2_k127_1359504_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1034.0
TLS2_k127_1359504_1 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009494 335.0
TLS2_k127_1359504_2 AMP-binding enzyme K00666 - - 0.0000000004959 65.0
TLS2_k127_1383402_0 GGDEF domain - - - 9.328e-289 907.0
TLS2_k127_1383402_1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - 1.539e-272 864.0
TLS2_k127_1383402_10 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000005143 188.0
TLS2_k127_1383402_11 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000001125 126.0
TLS2_k127_1383402_12 PIN domain - - - 0.0000000000000000000000000002157 119.0
TLS2_k127_1383402_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 1.649e-222 702.0
TLS2_k127_1383402_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009495 388.0
TLS2_k127_1383402_4 Peptidase dimerisation domain K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 398.0
TLS2_k127_1383402_5 beta-lactamase domain protein K06897 - 2.5.1.105 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 354.0
TLS2_k127_1383402_6 Acetamidase/Formamidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007935 284.0
TLS2_k127_1383402_7 Alcohol dehydrogenase GroES domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000527 247.0
TLS2_k127_1383402_8 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000002223 219.0
TLS2_k127_1383402_9 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000002935 188.0
TLS2_k127_1384229_0 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 468.0
TLS2_k127_1384229_1 TIM-barrel enzyme, possibly a dioxygenase - - - 0.00000000000000000000000000000000000000000000000003777 181.0
TLS2_k127_1384229_2 Carbohydrate family 9 binding domain-like - - - 0.0006693 43.0
TLS2_k127_139288_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001642 268.0
TLS2_k127_139288_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000007424 231.0
TLS2_k127_139288_2 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000000000004005 177.0
TLS2_k127_1411378_0 Phosphate sensor histidine kinase, HAMP and PAS domain-containing K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000002134 247.0
TLS2_k127_1411378_1 Transcriptional regulatory protein, C terminal K07658 - - 0.000000000000000000000000000000000000000000000000001034 187.0
TLS2_k127_144146_0 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002313 452.0
TLS2_k127_144146_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001703 267.0
TLS2_k127_1464216_0 mandelate racemase muconate lactonizing K08323 - 4.2.1.8 2.149e-200 631.0
TLS2_k127_1464216_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 6.606e-199 631.0
TLS2_k127_1464216_10 Methane oxygenase PmoA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005252 387.0
TLS2_k127_1464216_11 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 367.0
TLS2_k127_1464216_12 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 336.0
TLS2_k127_1464216_13 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 338.0
TLS2_k127_1464216_14 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 316.0
TLS2_k127_1464216_15 PFAM peptidase K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002952 294.0
TLS2_k127_1464216_16 Type II restriction enzyme, methylase subunits - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003836 302.0
TLS2_k127_1464216_17 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001518 275.0
TLS2_k127_1464216_18 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004702 286.0
TLS2_k127_1464216_19 FCD K05799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009666 258.0
TLS2_k127_1464216_2 ABC transporter K10441 - 3.6.3.17 6.803e-199 631.0
TLS2_k127_1464216_20 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002048 263.0
TLS2_k127_1464216_21 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002699 250.0
TLS2_k127_1464216_22 Belongs to the DapB family K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000313 207.0
TLS2_k127_1464216_23 PFAM Helicase conserved C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000006108 219.0
TLS2_k127_1464216_24 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000007887 199.0
TLS2_k127_1464216_25 HAD-superfamily hydrolase, subfamily IIB - - - 0.000000000000000000000000000000000000000000000001142 187.0
TLS2_k127_1464216_26 Conserved hypothetical protein (DUF2461) - - - 0.000000000000000000000000000000000000000000004893 171.0
TLS2_k127_1464216_27 - - - - 0.0000000000000000000000000000000000000000005218 167.0
TLS2_k127_1464216_28 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000006017 156.0
TLS2_k127_1464216_29 IA, variant 3 K06019 - 3.6.1.1 0.000000000000000000000000000000000000002346 167.0
TLS2_k127_1464216_3 PFAM Alcohol dehydrogenase GroES-like domain K00008,K00060 - 1.1.1.103,1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 479.0
TLS2_k127_1464216_30 - - - - 0.0000000003053 72.0
TLS2_k127_1464216_31 Putative cyclase K07130 - 3.5.1.9 0.0000001691 62.0
TLS2_k127_1464216_32 Protein of unknown function (DUF1634) - - - 0.0000009336 61.0
TLS2_k127_1464216_33 PFAM Major Facilitator Superfamily - - - 0.00002071 57.0
TLS2_k127_1464216_4 Ring hydroxylating alpha subunit (catalytic domain) K00479 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 457.0
TLS2_k127_1464216_5 Periplasmic binding proteins and sugar binding domain of LacI family K10439,K10552 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 443.0
TLS2_k127_1464216_6 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003893 449.0
TLS2_k127_1464216_7 Branched-chain amino acid transport system / permease component K10440,K10553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 408.0
TLS2_k127_1464216_8 D-galactarate dehydratase / Altronate hydrolase, C terminus K01685,K01708 - 4.2.1.42,4.2.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009777 405.0
TLS2_k127_1464216_9 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 388.0
TLS2_k127_1475415_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003286 542.0
TLS2_k127_1475415_1 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 552.0
TLS2_k127_1475415_2 Tfp pilus assembly protein FimV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 350.0
TLS2_k127_1475415_3 COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006695 293.0
TLS2_k127_1475415_4 - K09914 - - 0.00009002 54.0
TLS2_k127_148645_0 Protein kinase domain - - - 0.00000000000000000000000000000002696 146.0
TLS2_k127_1515543_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003868 511.0
TLS2_k127_1515543_1 PIN domain K07064 GO:0005575,GO:0005576 - 0.00000000000000000000000000000000000000002972 156.0
TLS2_k127_1515543_2 - - - - 0.0000000000006027 71.0
TLS2_k127_1515543_3 40-residue YVTN family beta-propeller repeat - - - 0.0000000002746 70.0
TLS2_k127_1580513_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 8.614e-297 936.0
TLS2_k127_1595372_0 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 342.0
TLS2_k127_1595372_1 Sugar (and other) transporter K08151 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009751 326.0
TLS2_k127_1595372_2 peptide deformylase activity K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.00000000000000000000000000000000000000000000000006125 183.0
TLS2_k127_1629934_0 Domain of unknown function (DUF3459) K01236 - 3.2.1.141 5.353e-279 874.0
TLS2_k127_1629934_1 High confidence in function and specificity - - - 2.435e-276 891.0
TLS2_k127_1629934_10 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 310.0
TLS2_k127_1629934_11 tRNA pseudouridine synthase activity K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003872 283.0
TLS2_k127_1629934_12 Domains REC, sigma54 interaction, HTH8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009548 261.0
TLS2_k127_1629934_13 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000002122 257.0
TLS2_k127_1629934_14 SurA N-terminal domain K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000009644 211.0
TLS2_k127_1629934_15 NmrA-like family K19267 - 1.6.5.2 0.000000000000000000000000000000000244 147.0
TLS2_k127_1629934_16 Alpha/beta hydrolase family K07020 - - 0.00000000000000000000000000000004005 142.0
TLS2_k127_1629934_17 GGDEF domain - - - 0.00000000000000000000000000008609 130.0
TLS2_k127_1629934_18 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.0000000000000000005722 94.0
TLS2_k127_1629934_19 response regulator - - - 0.000000000000000000989 92.0
TLS2_k127_1629934_2 Uncharacterised protein family (UPF0182) K09118 - - 9.792e-242 781.0
TLS2_k127_1629934_20 S4 RNA-binding domain K04762 - - 0.00000000000001396 79.0
TLS2_k127_1629934_3 Major Facilitator Superfamily - - - 2.222e-196 621.0
TLS2_k127_1629934_4 Belongs to the mandelate racemase muconate lactonizing enzyme family K01706 - 4.2.1.40 2.886e-196 641.0
TLS2_k127_1629934_5 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 506.0
TLS2_k127_1629934_6 PFAM aspartate glutamate uridylate kinase K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004259 491.0
TLS2_k127_1629934_7 Belongs to the DapA family K01707 - 4.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 433.0
TLS2_k127_1629934_8 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006815 375.0
TLS2_k127_1629934_9 eRF1 domain 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 308.0
TLS2_k127_16622_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.266e-240 766.0
TLS2_k127_16622_1 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 1.456e-237 747.0
TLS2_k127_16622_10 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 328.0
TLS2_k127_16622_11 Histidine kinase K02478 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 317.0
TLS2_k127_16622_12 Putative esterase K07017 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002641 274.0
TLS2_k127_16622_13 Two component transcriptional regulator, LytTR family K02477,K07705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003196 250.0
TLS2_k127_16622_14 Glycosyl transferase family 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000008002 239.0
TLS2_k127_16622_15 ubiE/COQ5 methyltransferase family K00570 - 2.1.1.17,2.1.1.71 0.0000000000000000000000000000000000000000000000000000000003359 211.0
TLS2_k127_16622_16 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000004509 205.0
TLS2_k127_16622_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00337,K00338 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000002225 183.0
TLS2_k127_16622_18 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000007345 189.0
TLS2_k127_16622_19 geranylgeranyl reductase activity K21401 - 1.3.99.38 0.000000000000000000000000000000000000000002052 172.0
TLS2_k127_16622_2 homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 594.0
TLS2_k127_16622_20 NnrU protein K21310 - 2.1.1.334 0.000000000000000000000000000000000002428 147.0
TLS2_k127_16622_21 integral membrane protein - - - 0.0000000000000000000000000000001425 140.0
TLS2_k127_16622_22 Isoprenylcysteine carboxyl methyltransferase K16168 - - 0.0000000000000000000000000004164 121.0
TLS2_k127_16622_23 - - - - 0.000000000000000000002283 98.0
TLS2_k127_16622_24 phosphoesterases, related to the Icc protein - - - 0.0000000000000000002114 102.0
TLS2_k127_16622_25 GMP synthase-glutamine amidotransferase - - - 0.00006146 56.0
TLS2_k127_16622_3 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 473.0
TLS2_k127_16622_4 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 460.0
TLS2_k127_16622_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003906 407.0
TLS2_k127_16622_6 PFAM ATPase associated with various cellular activities AAA_3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005457 383.0
TLS2_k127_16622_7 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005731 368.0
TLS2_k127_16622_8 ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 368.0
TLS2_k127_16622_9 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 343.0
TLS2_k127_1710434_0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175,K00177,K00187 - 1.2.7.11,1.2.7.3,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003196 520.0
TLS2_k127_1710434_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 512.0
TLS2_k127_1710434_10 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005635 285.0
TLS2_k127_1710434_11 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001205 269.0
TLS2_k127_1710434_12 Phosphomethylpyrimidine kinase K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000783 247.0
TLS2_k127_1710434_13 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000003193 214.0
TLS2_k127_1710434_14 O-Antigen ligase K18814 - - 0.000000000000000000000000000000000000000000000000001225 198.0
TLS2_k127_1710434_15 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000003658 186.0
TLS2_k127_1710434_16 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000000000000000000000000001347 192.0
TLS2_k127_1710434_17 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000008858 174.0
TLS2_k127_1710434_18 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000001305 181.0
TLS2_k127_1710434_19 Glycosyl transferase, family 9 K02843,K02849 - - 0.000000000000000000000000000000000000000000637 173.0
TLS2_k127_1710434_2 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 496.0
TLS2_k127_1710434_20 binds to the 23S rRNA K02939 - - 0.00000000000000000000000000000000000000004228 156.0
TLS2_k127_1710434_21 B3/4 domain - - - 0.0000000000000000000000000000000007108 143.0
TLS2_k127_1710434_22 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000008787 109.0
TLS2_k127_1710434_23 4Fe-4S dicluster domain K00176 - 1.2.7.3 0.00000000000000000000004802 105.0
TLS2_k127_1710434_24 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000614 96.0
TLS2_k127_1710434_25 Trm112p-like protein K00912,K09791 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.7.1.130 0.00000000000000000235 85.0
TLS2_k127_1710434_26 Polymer-forming cytoskeletal - - - 0.00000000000000001821 89.0
TLS2_k127_1710434_27 Cytochrome c - - - 0.000000003644 68.0
TLS2_k127_1710434_3 Pyruvate:ferredoxin oxidoreductase core domain II K00186 - 1.2.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002775 460.0
TLS2_k127_1710434_4 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 415.0
TLS2_k127_1710434_5 Large family of predicted nucleotide-binding domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 400.0
TLS2_k127_1710434_6 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 397.0
TLS2_k127_1710434_7 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003175 387.0
TLS2_k127_1710434_8 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 350.0
TLS2_k127_1710434_9 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005259 328.0
TLS2_k127_1717509_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 423.0
TLS2_k127_1717509_1 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004683 308.0
TLS2_k127_1717509_2 von Willebrand factor (vWF) type A domain - - - 0.000001139 57.0
TLS2_k127_176103_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001171 289.0
TLS2_k127_176103_1 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970,K00974 - 2.7.7.19,2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000001515 272.0
TLS2_k127_176103_2 Peptidase, M28 - - - 0.00001094 48.0
TLS2_k127_1805321_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000001404 235.0
TLS2_k127_1805321_1 PFAM Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000005726 221.0
TLS2_k127_1805321_2 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000002826 122.0
TLS2_k127_1872074_0 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 444.0
TLS2_k127_1872074_1 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003178 400.0
TLS2_k127_1872074_10 Phosphotransferase enzyme family - - - 0.000000000008598 71.0
TLS2_k127_1872074_11 prohibitin homologues - - - 0.000000001608 64.0
TLS2_k127_1872074_12 Parallel beta-helix repeat (Two copies) - - - 0.00001677 58.0
TLS2_k127_1872074_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 370.0
TLS2_k127_1872074_3 Transporter, CPA2 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 333.0
TLS2_k127_1872074_4 PFAM band 7 protein - - - 0.00000000000000000000000000000000000000000006128 166.0
TLS2_k127_1872074_5 MFS_1 like family K08161 - - 0.000000000000000000000000000000000000000001046 173.0
TLS2_k127_1872074_6 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.000000000000000000000000003884 128.0
TLS2_k127_1872074_7 PFAM Bacterial regulatory proteins, gntR family K07979 - - 0.00000000000000000001934 95.0
TLS2_k127_1872074_8 prohibitin homologues - - - 0.000000000000001094 88.0
TLS2_k127_1872074_9 response regulator, receiver - - - 0.0000000000002328 81.0
TLS2_k127_1880612_0 efflux transmembrane transporter activity - - - 2.333e-216 701.0
TLS2_k127_1880612_1 PFAM Aldehyde dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 609.0
TLS2_k127_1880612_10 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004891 316.0
TLS2_k127_1880612_11 Possible lysine decarboxylase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008783 306.0
TLS2_k127_1880612_12 PFAM Peptidase M16 inactive domain K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006809 311.0
TLS2_k127_1880612_13 Belongs to the aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000002122 266.0
TLS2_k127_1880612_14 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000002416 253.0
TLS2_k127_1880612_15 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582,K16898 - 3.1.11.5,3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000002361 263.0
TLS2_k127_1880612_16 Alginate export - - - 0.0000000000000000000000000000000000000000000000000000000000000104 236.0
TLS2_k127_1880612_17 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000001311 220.0
TLS2_k127_1880612_18 Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000001889 201.0
TLS2_k127_1880612_19 endonuclease III K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000007722 177.0
TLS2_k127_1880612_2 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 516.0
TLS2_k127_1880612_20 O-methyltransferase - - - 0.00000000000000000000000000000000000000000006333 169.0
TLS2_k127_1880612_21 retrograde transport, endosome to Golgi K07095 - - 0.000000000000000000000000004403 116.0
TLS2_k127_1880612_22 COG3857 ATP-dependent nuclease, subunit B K16899 - 3.6.4.12 0.000000000000000007955 100.0
TLS2_k127_1880612_23 Recombinase - - - 0.000000000000000115 82.0
TLS2_k127_1880612_24 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000003443 79.0
TLS2_k127_1880612_25 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.0000000006062 72.0
TLS2_k127_1880612_26 - - - - 0.0000003346 61.0
TLS2_k127_1880612_27 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0000009906 59.0
TLS2_k127_1880612_28 - - - - 0.000008248 57.0
TLS2_k127_1880612_29 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0006457,GO:0008150,GO:0009987 - 0.0002045 50.0
TLS2_k127_1880612_3 Peptidase M16 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 415.0
TLS2_k127_1880612_4 Protein of unknown function (DUF1343) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004798 409.0
TLS2_k127_1880612_5 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008277 392.0
TLS2_k127_1880612_6 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 391.0
TLS2_k127_1880612_7 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 365.0
TLS2_k127_1880612_8 PFAM Alcohol dehydrogenase, zinc-binding K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007564 363.0
TLS2_k127_1880612_9 thiolester hydrolase activity K01179,K06889,K10773,K15853 - 3.2.1.4,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006149 316.0
TLS2_k127_1883798_0 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 428.0
TLS2_k127_1883798_1 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K03790 - 2.3.1.128 0.000000000000000000000162 106.0
TLS2_k127_1883798_2 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000008937 72.0
TLS2_k127_1887360_0 Glutamine synthetase type III K01915 - 6.3.1.2 8.349e-297 927.0
TLS2_k127_1887360_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001464 282.0
TLS2_k127_1887360_2 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family K13687 - - 0.00000000000000000000000000000000000000000000000000000002043 216.0
TLS2_k127_1887360_3 PFAM PRC-barrel domain - - - 0.0000000000006275 79.0
TLS2_k127_1889138_0 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007315 420.0
TLS2_k127_1889138_1 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006046 252.0
TLS2_k127_1898789_0 Glutamate synthase central domain K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1066.0
TLS2_k127_1898789_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 9.176e-242 750.0
TLS2_k127_1898789_10 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01219 - 3.2.1.81 0.00000000000000000000000001572 121.0
TLS2_k127_1898789_11 - - - - 0.00000000000002765 75.0
TLS2_k127_1898789_12 - - - - 0.000000002142 59.0
TLS2_k127_1898789_2 Flavin containing amine oxidoreductase K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 1.499e-239 749.0
TLS2_k127_1898789_3 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 534.0
TLS2_k127_1898789_4 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 328.0
TLS2_k127_1898789_5 glycerophosphodiester phosphodiesterase activity K01126 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008081,GO:0008889,GO:0009279,GO:0016020,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044462,GO:0044464,GO:0046872,GO:0071944 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001087 285.0
TLS2_k127_1898789_6 Trehalose utilisation K09992 - - 0.00000000000000000000000000000000000000000000000000000001213 207.0
TLS2_k127_1898789_7 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000002693 191.0
TLS2_k127_1898789_8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000001096 133.0
TLS2_k127_1898789_9 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000000000000386 130.0
TLS2_k127_1899378_0 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0 1168.0
TLS2_k127_1899378_1 leucyl-tRNA aminoacylation K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 9.282e-314 984.0
TLS2_k127_1899378_10 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 575.0
TLS2_k127_1899378_11 Belongs to the aldehyde dehydrogenase family K00141,K22187 - 1.2.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 563.0
TLS2_k127_1899378_12 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000389 544.0
TLS2_k127_1899378_13 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007227 494.0
TLS2_k127_1899378_14 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 471.0
TLS2_k127_1899378_15 Protein of unknown function (DUF819) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009787 457.0
TLS2_k127_1899378_16 4Fe-4S single cluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006469 427.0
TLS2_k127_1899378_17 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 436.0
TLS2_k127_1899378_18 TIGRFAM deoxyguanosinetriphosphate triphosphohydrolase K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 404.0
TLS2_k127_1899378_19 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 337.0
TLS2_k127_1899378_2 peptidase S9A, prolyl oligopeptidase domain protein beta-propeller K01322 - 3.4.21.26 6.875e-294 917.0
TLS2_k127_1899378_20 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006105 325.0
TLS2_k127_1899378_21 Phosphotriesterase family K07048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 317.0
TLS2_k127_1899378_22 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 314.0
TLS2_k127_1899378_23 Electron transfer flavoprotein domain K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 308.0
TLS2_k127_1899378_24 chromosome segregation K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 336.0
TLS2_k127_1899378_25 Fumarylacetoacetate (FAA) hydrolase family K14259 - 4.2.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 329.0
TLS2_k127_1899378_26 metalloendopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008749 325.0
TLS2_k127_1899378_27 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 308.0
TLS2_k127_1899378_28 Belongs to the GHMP kinase family K00849 - 2.7.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002733 325.0
TLS2_k127_1899378_29 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 323.0
TLS2_k127_1899378_3 Alpha-2-Macroglobulin K06894 - - 1.533e-292 962.0
TLS2_k127_1899378_30 oxidation-reduction process K00826 GO:0003674,GO:0003824,GO:0004303,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006694,GO:0006703,GO:0006706,GO:0008150,GO:0008152,GO:0008202,GO:0008210,GO:0008610,GO:0009056,GO:0009058,GO:0009987,GO:0010817,GO:0016042,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0033764,GO:0034754,GO:0042445,GO:0042446,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0047045,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 303.0
TLS2_k127_1899378_31 Bacterial PH domain K08981 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 314.0
TLS2_k127_1899378_32 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001202 302.0
TLS2_k127_1899378_33 PLD-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001952 288.0
TLS2_k127_1899378_34 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003603 278.0
TLS2_k127_1899378_35 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002239 281.0
TLS2_k127_1899378_36 transferase activity, transferring glycosyl groups K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001029 298.0
TLS2_k127_1899378_37 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000004859 249.0
TLS2_k127_1899378_38 PFAM UbiA prenyltransferase K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000269 225.0
TLS2_k127_1899378_39 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000009432 223.0
TLS2_k127_1899378_4 Sodium:solute symporter family - - - 2.621e-286 890.0
TLS2_k127_1899378_40 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000002491 227.0
TLS2_k127_1899378_41 YqcI/YcgG family - - - 0.000000000000000000000000000000000000000000000000000000004458 207.0
TLS2_k127_1899378_42 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000001228 204.0
TLS2_k127_1899378_43 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000001486 196.0
TLS2_k127_1899378_44 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000963 176.0
TLS2_k127_1899378_45 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000239 188.0
TLS2_k127_1899378_46 COG2755 Lysophospholipase L1 and related esterases K10804 GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 0.0000000000000000000000000000000000000000008184 168.0
TLS2_k127_1899378_47 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000004349 158.0
TLS2_k127_1899378_48 Protein of unknown function (DUF1175) K09934 - - 0.000000000000000000000000000000000000002603 167.0
TLS2_k127_1899378_49 PFAM Uncharacterised protein family (UPF0227) K07000 - - 0.0000000000000000000000000000000000001885 151.0
TLS2_k127_1899378_5 efflux transmembrane transporter activity - - - 1.814e-271 865.0
TLS2_k127_1899378_50 Domain of unknown function (DUF374) K09778 - - 0.000000000000000000000000000000000001795 158.0
TLS2_k127_1899378_51 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000002812 142.0
TLS2_k127_1899378_52 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000003659 153.0
TLS2_k127_1899378_53 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000004368 124.0
TLS2_k127_1899378_54 Participates in the control of copper homeostasis K06201 - - 0.0000000000000000000000000003017 130.0
TLS2_k127_1899378_55 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0050896,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.000000000000000000000000003499 112.0
TLS2_k127_1899378_56 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - 0.00000000000000000000000002959 119.0
TLS2_k127_1899378_57 Nuclear protein SET K07117 - - 0.000000000000000000000001104 109.0
TLS2_k127_1899378_58 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity K03429 - 2.4.1.315 0.0000000000000000000213 94.0
TLS2_k127_1899378_59 Ribosomal L32p protein family K02911 - - 0.00000000000000009898 83.0
TLS2_k127_1899378_6 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - 2.903e-268 843.0
TLS2_k127_1899378_60 Bacterial PH domain K09167 - - 0.0000000000000001352 90.0
TLS2_k127_1899378_61 Ribosomal protein S20 K02968 - - 0.00000000000002406 76.0
TLS2_k127_1899378_62 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000005859 76.0
TLS2_k127_1899378_63 - - - - 0.0000000000001826 79.0
TLS2_k127_1899378_64 TonB C terminal - - - 0.00000000005363 74.0
TLS2_k127_1899378_65 TIGRFAM DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000003042 71.0
TLS2_k127_1899378_66 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000002852 71.0
TLS2_k127_1899378_67 Protein of unknown function, DUF481 K07283 - - 0.00000008827 63.0
TLS2_k127_1899378_68 PFAM Hemerythrin HHE cation binding domain protein - - - 0.000001035 58.0
TLS2_k127_1899378_7 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 4.793e-257 820.0
TLS2_k127_1899378_8 Peptidase S46 - - - 8.167e-237 753.0
TLS2_k127_1899378_9 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007471 593.0
TLS2_k127_1901542_0 Alpha-L-arabinofuranosidase C-terminal domain K01209 - 3.2.1.55 4.277e-232 735.0
TLS2_k127_1901542_1 Family 4 glycosyl hydrolase K07406 - 3.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009497 572.0
TLS2_k127_1901542_10 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000005439 286.0
TLS2_k127_1901542_11 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000001383 258.0
TLS2_k127_1901542_12 MazG family K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000672 259.0
TLS2_k127_1901542_13 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000001728 248.0
TLS2_k127_1901542_14 SelR domain K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000002535 214.0
TLS2_k127_1901542_15 PFAM Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000002391 188.0
TLS2_k127_1901542_16 Stage II sporulation protein E K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000001537 197.0
TLS2_k127_1901542_17 palmitoyl-(protein) hydrolase activity K06999 - - 0.000000000000000000000000000000000000000000004902 182.0
TLS2_k127_1901542_18 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000001924 106.0
TLS2_k127_1901542_19 Phage integrase family - - - 0.0000000000000000000000306 104.0
TLS2_k127_1901542_2 Domain of unknown function (DUF1929) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 584.0
TLS2_k127_1901542_20 N-acetylglutamate synthase K00619 GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1 0.000000000000004661 81.0
TLS2_k127_1901542_21 Domain of unknown function (DUF1844) - - - 0.0000000000004866 72.0
TLS2_k127_1901542_22 - - - - 0.00000002025 55.0
TLS2_k127_1901542_23 SMART Tetratricopeptide domain protein - - - 0.0000001095 64.0
TLS2_k127_1901542_24 - - - - 0.00004708 49.0
TLS2_k127_1901542_3 Aminotransferase class-III K00823 - 2.6.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 533.0
TLS2_k127_1901542_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008575 469.0
TLS2_k127_1901542_5 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 462.0
TLS2_k127_1901542_6 Protein kinase domain K08884 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 383.0
TLS2_k127_1901542_7 chaperone-mediated protein folding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 385.0
TLS2_k127_1901542_8 PQQ-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 331.0
TLS2_k127_1901542_9 Metallo-beta-lactamase superfamily K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001573 305.0
TLS2_k127_1904470_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 0.0 1185.0
TLS2_k127_1904470_1 MFS/sugar transport protein K03292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008229 480.0
TLS2_k127_1904470_2 endo-1,4-beta-xylanase activity K01181,K01198,K01209 - 3.2.1.37,3.2.1.55,3.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005029 393.0
TLS2_k127_1905459_0 Bacterial Ig-like domain (group 3) K20276 - - 0.000002912 58.0
TLS2_k127_1905459_1 Glycosyltransferase family 87 - - - 0.00002802 56.0
TLS2_k127_1907395_0 His Kinase A (phosphoacceptor) domain - - - 0.0 1118.0
TLS2_k127_1907395_1 MreB/Mbl protein K03569 GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005412 494.0
TLS2_k127_1907395_2 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 411.0
TLS2_k127_1907395_3 peptidyl-prolyl isomerase K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 333.0
TLS2_k127_1907395_4 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000002126 195.0
TLS2_k127_1907395_5 COG2076 Membrane transporters of cations and cationic drugs K11741 - - 0.0000000000000000000000000000000000002684 144.0
TLS2_k127_1913585_0 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 462.0
TLS2_k127_1913585_1 beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005857 449.0
TLS2_k127_1913585_2 PFAM Gluconate transporter K03299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 405.0
TLS2_k127_1913585_3 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000739 227.0
TLS2_k127_1920626_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008053 587.0
TLS2_k127_1920626_1 squalene-associated FAD-dependent desaturase K21677 - 1.17.8.1 0.000000000000000000000000000000000000000000002114 177.0
TLS2_k127_1932240_0 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 391.0
TLS2_k127_1932240_1 von Willebrand factor (vWF) type A domain K07114 - - 0.0000000000000000000000000000000000000001197 170.0
TLS2_k127_1932240_2 von Willebrand factor, type A K07114 - - 0.0000000000000732 81.0
TLS2_k127_1937083_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1154.0
TLS2_k127_1937083_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 3.657e-282 890.0
TLS2_k127_1937083_10 COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000003966 234.0
TLS2_k127_1937083_11 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000008307 230.0
TLS2_k127_1937083_12 Ferric uptake regulator family K22297 - - 0.000000000000000000000000000000000000000000000000000000001136 207.0
TLS2_k127_1937083_13 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000000000000000001776 179.0
TLS2_k127_1937083_14 T4-like virus tail tube protein gp19 - - - 0.00000000000000000000000000000000000000000000003767 173.0
TLS2_k127_1937083_15 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000004801 84.0
TLS2_k127_1937083_17 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.000000000214 73.0
TLS2_k127_1937083_18 Pepsy-associated tm helix - - - 0.0000007289 60.0
TLS2_k127_1937083_2 Periplasmic copper-binding protein (NosD) - - - 2.752e-246 783.0
TLS2_k127_1937083_3 Domain of unknown function (DUF4976) - - - 4.841e-201 638.0
TLS2_k127_1937083_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 533.0
TLS2_k127_1937083_5 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002281 281.0
TLS2_k127_1937083_6 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000478 287.0
TLS2_k127_1937083_7 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000259 273.0
TLS2_k127_1937083_8 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004399 266.0
TLS2_k127_1937083_9 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000421 263.0
TLS2_k127_1938721_0 Belongs to the DegT DnrJ EryC1 family K07806 - 2.6.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 361.0
TLS2_k127_1938721_1 MotA/TolQ/ExbB proton channel family K02556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001049 278.0
TLS2_k127_1938721_2 response - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002388 261.0
TLS2_k127_1938721_3 Flagellar Motor Protein K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003332 251.0
TLS2_k127_1938721_4 methyltransferase FkbM - - - 0.000000000000000000000000000000000000000000000000000000002375 221.0
TLS2_k127_1939617_0 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000003914 75.0
TLS2_k127_1939617_1 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.000005344 60.0
TLS2_k127_195061_0 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005235 485.0
TLS2_k127_195061_1 Alanine dehydrogenase/PNT, N-terminal domain K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 432.0
TLS2_k127_195061_2 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005285 388.0
TLS2_k127_195061_3 Histidine-specific methyltransferase, SAM-dependent K18911 - 2.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 302.0
TLS2_k127_195061_4 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000001603 253.0
TLS2_k127_195061_5 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.000000000000000000000000007703 111.0
TLS2_k127_195061_6 Tetratricopeptide repeat - - - 0.0000000000000000003777 98.0
TLS2_k127_195061_7 ThiS family - - - 0.0000000000001015 76.0
TLS2_k127_1957956_0 Peptidase, M16 K07263 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 6.152e-213 692.0
TLS2_k127_1962933_0 PFAM UDP-glucose GDP-mannose dehydrogenase family, NAD binding domain K02472,K13015 - 1.1.1.136,1.1.1.336 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 587.0
TLS2_k127_1962933_1 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 409.0
TLS2_k127_1962933_10 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase - - - 0.000000000000000000000003465 119.0
TLS2_k127_1962933_11 -O-antigen - - - 0.0000000001625 74.0
TLS2_k127_1962933_12 PLD-like domain K17717 - 3.1.4.4 0.000005544 59.0
TLS2_k127_1962933_2 Secretion ATPase, PEP-CTERM locus subfamily K02450 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001255 274.0
TLS2_k127_1962933_3 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000235 263.0
TLS2_k127_1962933_4 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003544 282.0
TLS2_k127_1962933_5 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008817 271.0
TLS2_k127_1962933_6 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000009472 184.0
TLS2_k127_1962933_7 polysaccharide biosynthetic process - - - 0.00000000000000000000000000000000000000000000009589 188.0
TLS2_k127_1962933_8 Capsular exopolysaccharide family K08252 - 2.7.10.1 0.0000000000000000000000000000000000000003046 165.0
TLS2_k127_1962933_9 protein involved in exopolysaccharide biosynthesis - - - 0.0000000000000000000000000000000000001473 158.0
TLS2_k127_1971806_0 Peptidase family M1 domain K01256 - 3.4.11.2 1.248e-255 818.0
TLS2_k127_1971806_1 Protein of unknown function (DUF3500) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 559.0
TLS2_k127_1971806_2 alpha-L-rhamnosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 484.0
TLS2_k127_1971806_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003464 407.0
TLS2_k127_1971806_4 von Willebrand factor type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 422.0
TLS2_k127_1971806_5 - - - - 0.00000000000000000000000000000000000001868 148.0
TLS2_k127_1971806_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000002815 149.0
TLS2_k127_1971806_7 helix_turn_helix, mercury resistance - - - 0.0000000000000000000003795 101.0
TLS2_k127_1971806_8 Tetratricopeptide repeat - - - 0.00000003608 61.0
TLS2_k127_1978357_0 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000002478 163.0
TLS2_k127_1978357_1 PFAM O-antigen polymerase - - - 0.000000000000000000000000000000004366 146.0
TLS2_k127_1978357_2 Pkd domain containing protein - - - 0.000000000000002658 86.0
TLS2_k127_1978357_3 PFAM glycosyl transferase group 1 - - - 0.000000000000623 81.0
TLS2_k127_1978357_4 Aminoglycoside phosphotransferase - - - 0.0000002561 64.0
TLS2_k127_1984676_0 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004657 426.0
TLS2_k127_1984676_1 - - - - 0.000000000000000000007002 104.0
TLS2_k127_1988947_0 Voltage gated chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 555.0
TLS2_k127_1988947_1 PQQ-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006694 486.0
TLS2_k127_1988947_2 thiolester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 383.0
TLS2_k127_1988947_3 oxidoreductase activity K00665 - 2.3.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 308.0
TLS2_k127_1988947_4 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000002305 155.0
TLS2_k127_1988947_5 Domain of unknown function (DUF892) - - - 0.000000000000000000000000000000000008847 151.0
TLS2_k127_1988947_6 PFAM RNP-1 like RNA-binding protein - - - 0.000000000000000000000000000003089 124.0
TLS2_k127_1988947_7 PFAM Cupin 2 conserved barrel domain protein K21700 - - 0.000000001274 68.0
TLS2_k127_1989244_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 6.478e-208 683.0
TLS2_k127_1989244_1 COG0188 Type IIA topoisomerase (DNA gyrase topo II topoisomerase IV) A subunit K02469 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 366.0
TLS2_k127_1989244_10 Bacterial regulatory proteins, tetR family - - - 0.000000000000000003126 96.0
TLS2_k127_1989244_11 PFAM Outer membrane efflux protein - - - 0.000000000000007461 89.0
TLS2_k127_1989244_2 cAMP biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 349.0
TLS2_k127_1989244_3 NYN domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002814 298.0
TLS2_k127_1989244_4 Trypsin-like serine protease - - - 0.0000000000000000000000000000000000000000001217 171.0
TLS2_k127_1989244_5 Serine aminopeptidase, S33 K06889 - - 0.0000000000000000000000000000000000000000003706 170.0
TLS2_k127_1989244_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000005618 129.0
TLS2_k127_1989244_8 Methyltransferase domain - - - 0.000000000000000000000000002004 121.0
TLS2_k127_1989244_9 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000005561 122.0
TLS2_k127_1991008_0 response to abiotic stimulus K06867 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002531 274.0
TLS2_k127_2006855_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 577.0
TLS2_k127_2006855_1 Mandelate Racemase Muconate Lactonizing - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005942 512.0
TLS2_k127_2006855_2 arabinan catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007949 474.0
TLS2_k127_2006855_3 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000444 414.0
TLS2_k127_2006855_4 PFAM Xylose isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006095 239.0
TLS2_k127_2006855_5 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000002755 204.0
TLS2_k127_2006855_6 myo-inosose-2 dehydratase activity - - - 0.00000000000000000000000000000000000000000000000009237 202.0
TLS2_k127_2014014_0 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004962 356.0
TLS2_k127_2014014_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003576 319.0
TLS2_k127_2014014_2 GYD domain - - - 0.000000000000000000000000003705 114.0
TLS2_k127_2027008_0 receptor K16091 - - 1.762e-202 655.0
TLS2_k127_2027008_1 KaiC K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 497.0
TLS2_k127_2027008_2 Histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 350.0
TLS2_k127_2029670_0 Glucose sorbosone dehydrogenase K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 532.0
TLS2_k127_2029670_1 beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000001101 216.0
TLS2_k127_2035023_0 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 428.0
TLS2_k127_2035023_1 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002084 291.0
TLS2_k127_2035023_2 Bacterial sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000008029 261.0
TLS2_k127_2035023_3 glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000006097 246.0
TLS2_k127_2035023_4 protein involved in exopolysaccharide biosynthesis K16554 - - 0.0000000000000000000000000000000000000000000000000000000000004239 237.0
TLS2_k127_2035023_5 Polysaccharide export protein K01991,K20988 - - 0.000000000000000000000000000000000000000000000007746 184.0
TLS2_k127_2035023_6 self proteolysis - - - 0.000000000000000000000000000000000000000000000412 192.0
TLS2_k127_2035023_7 Metallo-peptidase family M12B Reprolysin-like - - - 0.0000001448 65.0
TLS2_k127_2037673_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006334 506.0
TLS2_k127_2037673_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 368.0
TLS2_k127_2037673_10 Acetyltransferase (GNAT) domain - - - 0.00001289 56.0
TLS2_k127_2037673_2 peptidyl-lysine modification to peptidyl-hypusine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 351.0
TLS2_k127_2037673_3 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 338.0
TLS2_k127_2037673_4 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 294.0
TLS2_k127_2037673_5 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K00760,K04075 - 2.4.2.8,6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000001941 272.0
TLS2_k127_2037673_6 Belongs to the peptidase S8 family K17734 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002052 263.0
TLS2_k127_2037673_7 - - - - 0.000000000000000000000000000000000000000000000000000000004012 213.0
TLS2_k127_2037673_8 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000000003179 125.0
TLS2_k127_2037673_9 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins K22479 - - 0.00000007473 62.0
TLS2_k127_2062380_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008037 539.0
TLS2_k127_2065381_0 Protein of unknown function (DUF4038) - - - 0.0 1015.0
TLS2_k127_2065381_1 Glycosyl hydrolase family 3 K05349 - 3.2.1.21 2.045e-261 830.0
TLS2_k127_2065381_10 Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily K00850 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 458.0
TLS2_k127_2065381_11 Gluconate K03299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005198 426.0
TLS2_k127_2065381_12 N-acetylglucosaminylinositol deacetylase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 299.0
TLS2_k127_2065381_13 Concanavalin A-like lectin/glucanases superfamily - - - 0.0000000000000000000000000000000000000000000000000000000299 209.0
TLS2_k127_2065381_14 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.00000000000000000000000000000000000000000000000000000009674 200.0
TLS2_k127_2065381_15 HAD-hyrolase-like K19270 - 3.1.3.23 0.00000000000000000000000000000000000000000000005087 186.0
TLS2_k127_2065381_16 S1 P1 nuclease K05986 - 3.1.30.1 0.00000000000000000000000000000000000000000002368 173.0
TLS2_k127_2065381_17 DinB superfamily - - - 0.00000000000000000000000000000000000002384 149.0
TLS2_k127_2065381_18 PFAM von Willebrand factor type A - - - 0.000000000000000000000000000001314 139.0
TLS2_k127_2065381_19 membrane K08978 - - 0.000000000000000000000000000009509 126.0
TLS2_k127_2065381_2 Sulfate permease family K03321 - - 1.261e-215 684.0
TLS2_k127_2065381_20 TIGRFAM VWFA-related Acidobacterial domain - - - 0.00003286 58.0
TLS2_k127_2065381_21 - - - - 0.00008031 56.0
TLS2_k127_2065381_22 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0003214 53.0
TLS2_k127_2065381_23 oxidoreductase activity - - - 0.0003916 54.0
TLS2_k127_2065381_3 inositol 2-dehydrogenase activity - - - 4.734e-210 680.0
TLS2_k127_2065381_4 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 565.0
TLS2_k127_2065381_5 Trehalose utilisation K15538,K21132 - 3.2.1.130,3.2.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 551.0
TLS2_k127_2065381_6 carbohydrate kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 527.0
TLS2_k127_2065381_7 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008339 509.0
TLS2_k127_2065381_8 protein histidine kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004863 527.0
TLS2_k127_2065381_9 AbgT putative transporter family K12942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005305 504.0
TLS2_k127_2068629_0 Insulinase (Peptidase family M16) K07263 - - 0.0 1167.0
TLS2_k127_2068629_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 7.526e-211 666.0
TLS2_k127_2068629_10 flagellar motor switch protein FliG K02410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 391.0
TLS2_k127_2068629_11 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009673 396.0
TLS2_k127_2068629_12 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 377.0
TLS2_k127_2068629_13 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 347.0
TLS2_k127_2068629_14 Flagellar basal body protein FlaE K02390 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 315.0
TLS2_k127_2068629_15 The M ring may be actively involved in energy transduction K02409 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006485 282.0
TLS2_k127_2068629_16 flagellar motor switch protein FliM K02416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000785 276.0
TLS2_k127_2068629_17 Plays a role in the flagellum-specific transport system K02419 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003181 253.0
TLS2_k127_2068629_18 Penicillin binding protein transpeptidase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001103 244.0
TLS2_k127_2068629_19 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000001148 239.0
TLS2_k127_2068629_2 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01667,K01668 - 4.1.99.1,4.1.99.2 2.21e-204 650.0
TLS2_k127_2068629_20 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.0000000000000000000000000000000000000000000000000000000000000739 227.0
TLS2_k127_2068629_21 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K02405 - - 0.00000000000000000000000000000000000000000000601 183.0
TLS2_k127_2068629_22 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000000004574 168.0
TLS2_k127_2068629_23 GTP-binding signal recognition particle SRP54 K02404 - - 0.000000000000000000000000000000000000002014 160.0
TLS2_k127_2068629_24 Belongs to the flagella basal body rod proteins family K02388 - - 0.00000000000000000000000000000000000001187 150.0
TLS2_k127_2068629_25 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000004461 138.0
TLS2_k127_2068629_26 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02667 - - 0.000000000000000000000000000001205 128.0
TLS2_k127_2068629_27 Pfam matches to PF08238.7 Sel1, and to PF08238.7 Sel1, and to PF08238.7 Sel1, and to PF08238.7 Sel1 K07126 - - 0.00000000000000000000000000003583 135.0
TLS2_k127_2068629_28 HDOD domain - - - 0.00000000000000000000000000005721 126.0
TLS2_k127_2068629_29 Rhomboid family K19225 - 3.4.21.105 0.0000000000000000000000000002569 132.0
TLS2_k127_2068629_3 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 8.067e-195 628.0
TLS2_k127_2068629_30 - - - - 0.0000000000000000000000005403 117.0
TLS2_k127_2068629_31 Role in flagellar biosynthesis K02421 - - 0.000000000000000000000001231 116.0
TLS2_k127_2068629_32 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000009735 98.0
TLS2_k127_2068629_33 Flagellar assembly protein FliH K02411 - - 0.00000000000000001933 91.0
TLS2_k127_2068629_34 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.00000000000000003571 89.0
TLS2_k127_2068629_35 Type III flagellar switch regulator (C-ring) FliN C-term K02417 - - 0.0000000000000732 81.0
TLS2_k127_2068629_36 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.0000000000001011 80.0
TLS2_k127_2068629_38 Role in flagellar biosynthesis K02420 - - 0.00000000001179 76.0
TLS2_k127_2068629_39 Flagellar hook-basal body complex protein FliE K02408 - - 0.00000000008938 66.0
TLS2_k127_2068629_4 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008265 596.0
TLS2_k127_2068629_40 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 - 0.0000000002149 66.0
TLS2_k127_2068629_41 PFAM Surface presentation of K02417 - - 0.00000000062 64.0
TLS2_k127_2068629_42 inhibitor of MCP methylation homolog of CheC K03409 - - 0.000000001192 67.0
TLS2_k127_2068629_43 Flagellar hook-length control protein K02414 - - 0.00001814 57.0
TLS2_k127_2068629_44 PFAM flagellar biosynthesis protein, FliO K02418 - - 0.0001873 51.0
TLS2_k127_2068629_5 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 608.0
TLS2_k127_2068629_6 Flagellar protein export ATPase FliI K02412,K03224 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 511.0
TLS2_k127_2068629_7 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 494.0
TLS2_k127_2068629_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 443.0
TLS2_k127_2068629_9 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008073 425.0
TLS2_k127_2079108_0 - - - - 0.000000000000000000000000002129 121.0
TLS2_k127_2079108_1 oxidoreductase activity - - - 0.0000000000000000000000001447 124.0
TLS2_k127_2079108_2 Carboxypeptidase regulatory-like domain - - - 0.000000000000001044 82.0
TLS2_k127_2089582_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 556.0
TLS2_k127_2089582_1 TonB-dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004394 407.0
TLS2_k127_2089582_2 Domain of unknown function (DUF4154) - - - 0.000000000000000000000000000000002437 141.0
TLS2_k127_2089582_3 Histone methylation protein DOT1 - - - 0.000000000000000000000000000002352 129.0
TLS2_k127_2095374_0 ATPase activity K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 374.0
TLS2_k127_2095374_1 ABC-2 family transporter protein K01992 - - 0.0001648 50.0
TLS2_k127_2112335_0 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 380.0
TLS2_k127_2112335_1 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005081 316.0
TLS2_k127_2112335_10 Copper binding periplasmic protein CusF K07152 - - 0.000000000000000000000000000000000000000000001927 175.0
TLS2_k127_2112335_11 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000001101 150.0
TLS2_k127_2112335_12 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.0000000000000000000000000000000003363 138.0
TLS2_k127_2112335_13 PFAM RNP-1 like RNA-binding protein - - - 0.00000000000000000000000001201 112.0
TLS2_k127_2112335_14 - - - - 0.00000000000000004342 87.0
TLS2_k127_2112335_15 AntiSigma factor - - - 0.0001843 52.0
TLS2_k127_2112335_2 poly(3-hydroxybutyrate) depolymerase activity K07019 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0071704 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 304.0
TLS2_k127_2112335_3 lipoprotein localization to outer membrane K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006457 295.0
TLS2_k127_2112335_4 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008959 246.0
TLS2_k127_2112335_5 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000001018 252.0
TLS2_k127_2112335_6 Fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000001717 242.0
TLS2_k127_2112335_7 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000005041 224.0
TLS2_k127_2112335_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000005889 227.0
TLS2_k127_2112335_9 - - - - 0.000000000000000000000000000000000000000000001222 175.0
TLS2_k127_2115512_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 2.561e-219 688.0
TLS2_k127_2115512_1 cytochrome c nitrite reductase K15876 - - 0.00000000000000000000000000000000000000000000000000000008774 198.0
TLS2_k127_2115512_2 COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms - - - 0.00000000000000000000209 104.0
TLS2_k127_2116277_0 L-lactate dehydrogenase K00101,K16422 - 1.1.2.3,1.1.3.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 522.0
TLS2_k127_2116277_1 PFAM L-lactate permease K03303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 373.0
TLS2_k127_2116277_2 aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000008236 154.0
TLS2_k127_2141857_0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02351 - - 0.000000000000000000000000000000000000000000000000000000000000000003088 235.0
TLS2_k127_2141857_1 Tfp pilus assembly protein FimV - - - 0.000000000006056 74.0
TLS2_k127_2141857_2 Calcineurin-like phosphoesterase - - - 0.00003748 50.0
TLS2_k127_2145738_0 Tetratricopeptide repeat K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 590.0
TLS2_k127_2145738_1 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000003265 219.0
TLS2_k127_2145738_2 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000003866 85.0
TLS2_k127_2156100_0 Membrane-bound dehydrogenase domain - - - 1.088e-220 716.0
TLS2_k127_2156100_1 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 489.0
TLS2_k127_2156100_2 beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007588 250.0
TLS2_k127_2156100_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000001616 67.0
TLS2_k127_2202240_0 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 605.0
TLS2_k127_2202240_1 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006802 533.0
TLS2_k127_2202240_10 PFAM FRG domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007085 341.0
TLS2_k127_2202240_11 metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 319.0
TLS2_k127_2202240_12 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 316.0
TLS2_k127_2202240_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003946 303.0
TLS2_k127_2202240_14 thiamine kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000008611 256.0
TLS2_k127_2202240_15 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000000000000000001893 203.0
TLS2_k127_2202240_16 3D domain - - - 0.0000000000000025 82.0
TLS2_k127_2202240_2 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 525.0
TLS2_k127_2202240_3 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008753 522.0
TLS2_k127_2202240_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009662 531.0
TLS2_k127_2202240_5 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 486.0
TLS2_k127_2202240_6 Male sterility protein K12454 - 5.1.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007557 471.0
TLS2_k127_2202240_7 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006982 420.0
TLS2_k127_2202240_8 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 413.0
TLS2_k127_2202240_9 Protein of unknown function (DUF1698) K15257 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 364.0
TLS2_k127_2202569_0 Belongs to the peptidase S8 family K08651,K14645 - 3.4.21.66 0.0 1321.0
TLS2_k127_2202569_1 Permease family K06901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 436.0
TLS2_k127_2202569_2 protein kinase activity K01972,K02342,K04096 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 2.7.7.7,6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 380.0
TLS2_k127_2202569_3 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000002685 202.0
TLS2_k127_2202569_4 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000001057 186.0
TLS2_k127_2202569_5 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000022 157.0
TLS2_k127_2208115_0 cobalamin binding K01847,K01849 - 5.4.99.2 0.0 1159.0
TLS2_k127_2208115_1 CoA carboxylase activity K01966,K17489 - 2.1.3.1,2.1.3.15,6.4.1.3 9.665e-274 851.0
TLS2_k127_2208115_2 Conserved carboxylase domain K03416 - 2.1.3.1 3.189e-265 823.0
TLS2_k127_2208115_3 Methylmalonyl-CoA mutase K01847,K03763,K14447 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016999,GO:0017144,GO:0019541,GO:0019678,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046459,GO:0071704,GO:0071944 2.7.7.7,5.4.99.2,5.4.99.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 561.0
TLS2_k127_2208115_4 ArgK protein K07588 GO:0003674,GO:0003824,GO:0003924,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004939 469.0
TLS2_k127_2208115_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000003435 270.0
TLS2_k127_2208115_6 TIGRFAM diguanylate cyclase (GGDEF) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003293 274.0
TLS2_k127_2208115_7 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.00000000000000000000000000000000000000007157 175.0
TLS2_k127_2208115_8 Biotin-requiring enzyme K17490 - 2.1.3.1 0.00000000000000000000000000000000001606 140.0
TLS2_k127_2221614_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 535.0
TLS2_k127_2231335_0 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 419.0
TLS2_k127_2231335_1 PFAM PfkB domain protein K00856 - 2.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000018 274.0
TLS2_k127_2231335_2 Amine oxidase, flavin-containing - - - 0.000000000000000000000000001316 116.0
TLS2_k127_2231459_0 ABC transporter - - - 1.753e-254 809.0
TLS2_k127_2231459_1 Fad linked oxidase - - - 1.362e-228 715.0
TLS2_k127_2231459_2 - - - - 0.00000000000000000000000000000000000000000000000000000007099 222.0
TLS2_k127_2234325_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 5.54e-309 959.0
TLS2_k127_2234325_1 Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 320.0
TLS2_k127_2234325_10 SNARE associated Golgi protein K01077 - 3.1.3.1 0.000000000000000000000126 105.0
TLS2_k127_2234325_11 aminopeptidase N - - - 0.0000000000000000806 92.0
TLS2_k127_2234325_12 PFAM FHA domain - - - 0.0000000000044 77.0
TLS2_k127_2234325_13 Forkhead associated domain K01990,K21397 - - 0.00000000002754 69.0
TLS2_k127_2234325_14 NHL repeat - - - 0.0001128 55.0
TLS2_k127_2234325_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000003812 222.0
TLS2_k127_2234325_3 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000009359 233.0
TLS2_k127_2234325_4 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000002826 242.0
TLS2_k127_2234325_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000004613 224.0
TLS2_k127_2234325_6 Protein serine threonine phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000001724 198.0
TLS2_k127_2234325_7 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.00000000000000000000000000000000000000001128 170.0
TLS2_k127_2234325_9 histidine kinase A domain protein - - - 0.000000000000000000000001318 108.0
TLS2_k127_2284325_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003718 298.0
TLS2_k127_2284325_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009271 272.0
TLS2_k127_2291441_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 1.182e-215 683.0
TLS2_k127_2291441_1 PQQ-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 530.0
TLS2_k127_2291441_10 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.00000000000000000000000000000000000000000000000000003423 198.0
TLS2_k127_2291441_2 protein kinase related protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 483.0
TLS2_k127_2291441_3 Iron-containing alcohol dehydrogenase K00001,K13954 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 361.0
TLS2_k127_2291441_4 beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 300.0
TLS2_k127_2291441_5 protein kinase related protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001116 291.0
TLS2_k127_2291441_6 TonB-dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002391 289.0
TLS2_k127_2291441_7 ROK family K00886 - 2.7.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000009263 261.0
TLS2_k127_2291441_8 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000002037 211.0
TLS2_k127_2291441_9 6-phosphogluconolactonase K01057 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 0.000000000000000000000000000000000000000000000000000005167 200.0
TLS2_k127_2293447_0 Bacterial sugar transferase K03606 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006037 447.0
TLS2_k127_2293447_1 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 347.0
TLS2_k127_2293447_2 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002722 304.0
TLS2_k127_2293447_3 Glycosyl transferase family group 2 K07011 - - 0.00000000000000000000000000000000000000006658 171.0
TLS2_k127_2293447_4 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000007466 160.0
TLS2_k127_2293447_5 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.00000000000000000000000000000005526 127.0
TLS2_k127_2293447_6 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000186 119.0
TLS2_k127_2294547_0 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003247 522.0
TLS2_k127_2294547_1 TIGRFAM acetaldehyde dehydrogenase (acetylating) K00132 - 1.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005222 499.0
TLS2_k127_2294547_10 Protein of unknown function (DUF3485) - - - 0.00000000000000000000000000000000004475 146.0
TLS2_k127_2294547_11 - - - - 0.00008336 54.0
TLS2_k127_2294547_2 PFAM Type II secretion system protein E K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007825 469.0
TLS2_k127_2294547_3 Lysin motif K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 343.0
TLS2_k127_2294547_4 PFAM Type II secretion system F domain K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005975 293.0
TLS2_k127_2294547_5 Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000000000000000000005212 208.0
TLS2_k127_2294547_6 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000001272 196.0
TLS2_k127_2294547_7 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000003624 174.0
TLS2_k127_2294547_8 ethanolamine catabolic process K04027 - - 0.00000000000000000000000000000000000002159 146.0
TLS2_k127_2294547_9 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000007099 147.0
TLS2_k127_2295439_0 TonB-dependent receptor - - - 0.0 1157.0
TLS2_k127_2295439_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000003198 185.0
TLS2_k127_2295439_2 Sodium bile acid symporter family K03453 - - 0.00000000000000000000000002169 111.0
TLS2_k127_2315176_0 Belongs to the ribulokinase family K00853 - 2.7.1.16 1.427e-235 741.0
TLS2_k127_2315176_1 Pfam L-fucose isomerase, C-terminal domain - - - 3.845e-219 691.0
TLS2_k127_2315176_2 PFAM Pyrrolo-quinoline quinone K00117 - 1.1.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004741 562.0
TLS2_k127_2315176_3 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006631 473.0
TLS2_k127_2315176_4 L-ribulose-5-phosphate 4-epimerase K03077 - 5.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000005107 259.0
TLS2_k127_2315176_5 COG1309 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000002277 179.0
TLS2_k127_2315176_6 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000003795 177.0
TLS2_k127_2315176_7 Cupin domain - - - 0.000000000000000000000000000000000000006768 151.0
TLS2_k127_2315176_8 PFAM Amidase - - - 0.0000000000000000002129 90.0
TLS2_k127_2330139_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 590.0
TLS2_k127_2330139_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 445.0
TLS2_k127_2330139_2 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000000000431 187.0
TLS2_k127_2330139_3 Domain of unknown function (DUF4437) - - - 0.00000000000000000000000000000000000000000000000004207 187.0
TLS2_k127_2330139_4 Protein of unknown function DUF86 - - - 0.000000000000000000000000000000000000002816 157.0
TLS2_k127_2330139_5 GtrA-like protein - - - 0.000000000000000000000000000186 119.0
TLS2_k127_2330139_6 Acts as a magnesium transporter K06213 - - 0.000000000000000015 85.0
TLS2_k127_2330139_7 myo-inosose-2 dehydratase activity - - - 0.00000000000002034 84.0
TLS2_k127_2330139_8 Nucleotidyltransferase domain - - - 0.000004848 55.0
TLS2_k127_2332377_0 Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 401.0
TLS2_k127_2332377_1 WbqC-like protein family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005969 294.0
TLS2_k127_2332377_10 Methyltransferase domain - - - 0.00000007323 66.0
TLS2_k127_2332377_11 DegT/DnrJ/EryC1/StrS aminotransferase family K13010 - 2.6.1.102 0.00000007591 57.0
TLS2_k127_2332377_12 Glycosyl transferases group 1 - - - 0.0000009212 62.0
TLS2_k127_2332377_2 Protein of unknown function (DUF1698) - - - 0.0000000000000000000000000000000000000000006578 175.0
TLS2_k127_2332377_3 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000003514 148.0
TLS2_k127_2332377_4 Glycosyl transferase 4-like - - - 0.000000000000000000000000000004849 135.0
TLS2_k127_2332377_5 Protein of unknown function DUF115 - - - 0.0000000000000000000000000009432 132.0
TLS2_k127_2332377_6 Glycosyltransferase Family 4 K19424 - - 0.000000000000000000000000145 122.0
TLS2_k127_2332377_7 Asparagine synthase K01953 - 6.3.5.4 0.0000000000005245 71.0
TLS2_k127_2332377_8 Evidence 4 Homologs of previously reported genes of - - - 0.0000000344 65.0
TLS2_k127_2332377_9 Evidence 4 Homologs of previously reported genes of - - - 0.0000000493 65.0
TLS2_k127_2334100_0 hydrolase, family 3 K05349 - 3.2.1.21 2.925e-263 830.0
TLS2_k127_2334100_1 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008541 420.0
TLS2_k127_2334100_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 334.0
TLS2_k127_2334100_3 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 301.0
TLS2_k127_2334100_4 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001055 270.0
TLS2_k127_2334100_5 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000003493 262.0
TLS2_k127_2334100_6 Site-specific DNA-methyltransferase (Adenine-specific) K06223 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000005921 240.0
TLS2_k127_2334100_7 Large-conductance mechanosensitive channel, MscL K03282 - - 0.000000000000000000000000000000000000000000000001188 179.0
TLS2_k127_2334100_8 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.000000000000000000000000000000002156 132.0
TLS2_k127_2334100_9 cheY-homologous receiver domain - - - 0.000000000000000000000000000001013 125.0
TLS2_k127_2339256_0 TonB-dependent receptor - - - 0.0 1224.0
TLS2_k127_2339256_1 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006585 375.0
TLS2_k127_2339256_2 PFAM chemotaxis sensory transducer K03406,K05874 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008423 284.0
TLS2_k127_2339256_3 - - - - 0.000000000000000000000000000005871 126.0
TLS2_k127_2339256_4 symporter activity K03307,K11928 - - 0.000000000000000000000000000008173 126.0
TLS2_k127_2339256_5 peptidyl-tyrosine sulfation - - - 0.000000000205 67.0
TLS2_k127_2339256_6 PRC-barrel domain - - - 0.0000001554 64.0
TLS2_k127_2339282_0 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000001677 226.0
TLS2_k127_2339282_1 PIN domain - - - 0.000000000000000000000000000000000000000000000002079 181.0
TLS2_k127_2339282_2 Uncharacterised protein family UPF0052 - - - 0.000000000000000000000000000000009569 135.0
TLS2_k127_2339282_3 symporter activity K03307,K11928 - - 0.00000000000000000000000000004595 121.0
TLS2_k127_2341660_0 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000114 183.0
TLS2_k127_2341660_1 Methanol dehydrogenase K06872 - - 0.0000000000000000000000000003038 128.0
TLS2_k127_2341660_2 nucleotidyltransferase activity - - - 0.000000000000000004891 91.0
TLS2_k127_2352273_0 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 375.0
TLS2_k127_2352273_1 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 367.0
TLS2_k127_235454_0 Belongs to the citrate synthase family K01647,K15234 - 2.3.3.1,4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000005571 246.0
TLS2_k127_235454_1 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.00000000000000000000000000000000000000000000000000003821 192.0
TLS2_k127_235454_2 - - - - 0.0000000000000000000000000000000003372 134.0
TLS2_k127_2378267_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 1.268e-297 945.0
TLS2_k127_2378267_1 Belongs to the aldehyde dehydrogenase family K00135 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009013,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 572.0
TLS2_k127_2378267_10 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 350.0
TLS2_k127_2378267_11 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 321.0
TLS2_k127_2378267_12 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 319.0
TLS2_k127_2378267_13 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009746 261.0
TLS2_k127_2378267_14 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000002127 240.0
TLS2_k127_2378267_15 Divalent cation transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000009644 234.0
TLS2_k127_2378267_16 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000001876 213.0
TLS2_k127_2378267_17 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000004252 204.0
TLS2_k127_2378267_18 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000007746 192.0
TLS2_k127_2378267_19 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000001759 179.0
TLS2_k127_2378267_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 548.0
TLS2_k127_2378267_20 Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion K02564 - 3.5.99.6 0.00000000000000000000000000000000000000008671 162.0
TLS2_k127_2378267_21 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000001239 143.0
TLS2_k127_2378267_22 TIGRFAM methyltransferase FkbM - - - 0.000000000000000000002409 106.0
TLS2_k127_2378267_23 COG0642 Signal transduction histidine kinase K20973 - 2.7.13.3 0.0000000000000000007796 101.0
TLS2_k127_2378267_24 RNA polymerase-binding protein DksA K06204 - - 0.00000000000000002572 88.0
TLS2_k127_2378267_25 Protein of unknown function, DUF255 K04084 - 1.8.1.8 0.0001796 50.0
TLS2_k127_2378267_3 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 490.0
TLS2_k127_2378267_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 444.0
TLS2_k127_2378267_5 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005225 426.0
TLS2_k127_2378267_6 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007312 368.0
TLS2_k127_2378267_7 ABC transporter K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 357.0
TLS2_k127_2378267_8 glycerophosphoryl diester phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 346.0
TLS2_k127_2378267_9 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 335.0
TLS2_k127_243225_0 Belongs to the PdxA family K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071 468.0
TLS2_k127_243225_1 kinase activity K22129 - 2.7.1.219,2.7.1.220 0.00000000000000000000000000000000000000000000000000000000001143 223.0
TLS2_k127_243225_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000008197 124.0
TLS2_k127_243225_3 - - - - 0.0000000000000939 73.0
TLS2_k127_2433865_0 Aminotransferase K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 376.0
TLS2_k127_2433865_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000007682 159.0
TLS2_k127_2453020_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 2.093e-194 625.0
TLS2_k127_2453020_1 beta-galactosidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 527.0
TLS2_k127_2453020_2 Protein conserved in bacteria K07011 - - 0.000000000000000000000000000000000000000000000004167 183.0
TLS2_k127_2462336_0 electron transfer activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 417.0
TLS2_k127_2462336_1 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000000000007509 203.0
TLS2_k127_2520315_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004165 390.0
TLS2_k127_2520315_1 16S rRNA methyltransferase RsmB/F K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 304.0
TLS2_k127_2520315_2 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001425 286.0
TLS2_k127_2520315_3 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000005349 251.0
TLS2_k127_2520315_4 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000007439 185.0
TLS2_k127_2520315_5 thioesterase K07107 - - 0.000000000000000000000000005975 116.0
TLS2_k127_2520315_6 PFAM Protein kinase domain K12132 - 2.7.11.1 0.00000000000001178 83.0
TLS2_k127_2546_0 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 510.0
TLS2_k127_2546_1 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 451.0
TLS2_k127_2546_2 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000577 380.0
TLS2_k127_2546_3 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006732 370.0
TLS2_k127_2546_4 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 348.0
TLS2_k127_2546_5 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003824 288.0
TLS2_k127_2546_6 Phosphoribulokinase / Uridine kinase family K00855,K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.19,2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000339 270.0
TLS2_k127_2546_7 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000005502 256.0
TLS2_k127_2546_8 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.00000000003351 75.0
TLS2_k127_2557694_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.17,6.1.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 451.0
TLS2_k127_2557694_1 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 310.0
TLS2_k127_2557694_2 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000006431 203.0
TLS2_k127_256513_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K01782,K07516 - 1.1.1.35,4.2.1.17,5.1.2.3 3.521e-199 651.0
TLS2_k127_256513_1 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 544.0
TLS2_k127_256513_2 Belongs to the glycosyl hydrolase 13 family K07214 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004345 412.0
TLS2_k127_256513_3 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001288 258.0
TLS2_k127_256513_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004047 245.0
TLS2_k127_256513_5 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000003133 199.0
TLS2_k127_256513_6 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000008516 158.0
TLS2_k127_256513_9 Dodecin - - - 0.0000000000002927 70.0
TLS2_k127_2571774_0 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second K01958 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.1 4.492e-291 900.0
TLS2_k127_2574990_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009085 359.0
TLS2_k127_2574990_1 PFAM glycoside hydrolase, family 10 K01181 - 3.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 308.0
TLS2_k127_2576789_0 Protein of unknown function (DUF1501) - - - 2.559e-233 726.0
TLS2_k127_2576789_1 Planctomycete cytochrome C - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 320.0
TLS2_k127_2576789_2 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000005894 109.0
TLS2_k127_2584443_0 Pfam:DUF1446 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 590.0
TLS2_k127_2584443_1 TIGRFAM citrate H symporter, CitMHS family K03300 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006132 526.0
TLS2_k127_2584443_2 Belongs to the glycosyl hydrolase 13 family K07214 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008 504.0
TLS2_k127_2584443_3 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008157 453.0
TLS2_k127_2584443_4 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000584 362.0
TLS2_k127_2584443_5 transmembrane signaling receptor activity K03406,K05874 - - 0.000000000000000000000000000000000000000000000000000000006943 211.0
TLS2_k127_2584443_6 - - - - 0.00000000000000000000000000000000006938 136.0
TLS2_k127_2612225_0 Cleaves the N-terminal amino acid of tripeptides K01258 - 3.4.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007871 487.0
TLS2_k127_2612225_1 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 463.0
TLS2_k127_2612225_2 choline dehydrogenase activity - - - 0.000000000000000000000000000001369 123.0
TLS2_k127_2658733_0 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 406.0
TLS2_k127_2658733_1 AAA ATPase domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 323.0
TLS2_k127_2658733_2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000002253 252.0
TLS2_k127_2658733_3 - - - - 0.00000000000000003361 83.0
TLS2_k127_266227_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 400.0
TLS2_k127_266227_1 Hemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008155 286.0
TLS2_k127_266227_2 cAMP biosynthetic process K03641 - - 0.0000000000000000001544 105.0
TLS2_k127_266227_3 Domain of unknown function DUF302 - - - 0.00000000000001006 76.0
TLS2_k127_2665906_0 DNA primase activity - - - 0.0000000000000000000000000000000000000000000000000000459 191.0
TLS2_k127_2665906_1 Dehydrogenase K00008 GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034193,GO:0034195,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.14 0.000000000000000000000000000000000000000002985 158.0
TLS2_k127_2665906_2 Iron-storage protein K02217 - 1.16.3.2 0.0000000000000000000000009157 109.0
TLS2_k127_2676952_0 type II secretion system K12511 - - 0.00000000000000000000000000000000000000000000000000000000000001229 238.0
TLS2_k127_2676952_1 Type II secretion system (T2SS), protein F K12510 - - 0.000000000000000000000000000000000000000000000000000000001305 216.0
TLS2_k127_2676952_2 PFAM type II secretion system protein E K02283,K03609 - - 0.0000000000000000000000000005141 114.0
TLS2_k127_2676952_3 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000001083 113.0
TLS2_k127_2690395_0 Amidohydrolase family K01464 - 3.5.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 334.0
TLS2_k127_2690395_1 Carbon-nitrogen hydrolase K01431 - 3.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000001679 257.0
TLS2_k127_2690395_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000001181 244.0
TLS2_k127_2711246_0 cellulose binding - - - 2.472e-217 677.0
TLS2_k127_2711246_1 myo-inosose-2 dehydratase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 321.0
TLS2_k127_2711246_2 - - - - 0.000000000000000000000000000000000001114 144.0
TLS2_k127_2711246_3 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - 0.000000000000000000000000000000001994 146.0
TLS2_k127_2711246_4 Protein of unknown function (DUF1572) - - - 0.000000000000000001287 89.0
TLS2_k127_2711246_5 ABC-2 family transporter protein K01992 - - 0.00000001556 55.0
TLS2_k127_2756116_0 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 419.0
TLS2_k127_2756116_1 Deoxyhypusine synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 398.0
TLS2_k127_2756116_2 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001273 286.0
TLS2_k127_2756116_3 Oxidoreductase FAD-binding domain - - - 0.000000000000000000001741 104.0
TLS2_k127_2756116_4 BON domain K04065 - - 0.000000000955 61.0
TLS2_k127_2767756_0 Carboxypeptidase regulatory-like domain - - - 2.107e-246 795.0
TLS2_k127_277351_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 304.0
TLS2_k127_277351_1 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000005998 133.0
TLS2_k127_277436_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 485.0
TLS2_k127_278725_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004998 543.0
TLS2_k127_278725_1 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 479.0
TLS2_k127_278725_2 TIGRFAM tripartite ATP-independent periplasmic transporter solute receptor, DctP family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009276 405.0
TLS2_k127_278725_3 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 361.0
TLS2_k127_278725_4 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) K00878 - 2.7.1.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002669 282.0
TLS2_k127_278725_5 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.00000000000000000000000000000000000002792 163.0
TLS2_k127_2806952_0 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 612.0
TLS2_k127_2806952_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000000000000000000000000000000000000000002191 186.0
TLS2_k127_2806952_2 COG1457 Purine-cytosine permease and related proteins - - - 0.000000000000002961 77.0
TLS2_k127_2809436_0 Probably functions as a manganese efflux pump - - - 0.000000000000000000000000000000006745 143.0
TLS2_k127_2809436_1 - - - - 0.00000000006873 74.0
TLS2_k127_2809436_2 PFAM ABC transporter transmembrane region K06147,K18889 - - 0.00001168 51.0
TLS2_k127_2821687_0 lipolytic protein G-D-S-L family - - - 2.756e-224 706.0
TLS2_k127_2827967_0 Bacterial protein of unknown function (DUF885) - - - 5.318e-207 666.0
TLS2_k127_2827967_1 Protein of unknown function (DUF2867) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 460.0
TLS2_k127_2827967_10 Transposase IS200 like K07491 - - 0.00000000000000000000000000000000000000000000000000000003512 206.0
TLS2_k127_2827967_11 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000005262 141.0
TLS2_k127_2827967_12 - - - - 0.00000000000000000000000459 112.0
TLS2_k127_2827967_13 - - - - 0.0002231 46.0
TLS2_k127_2827967_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K04127,K11325,K21174 - 5.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008764 435.0
TLS2_k127_2827967_3 Leucyl aminopeptidase (Aminopeptidase T) K19689 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006512 425.0
TLS2_k127_2827967_4 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 313.0
TLS2_k127_2827967_5 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 300.0
TLS2_k127_2827967_6 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003397 271.0
TLS2_k127_2827967_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003765 287.0
TLS2_k127_2827967_8 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000007739 261.0
TLS2_k127_2827967_9 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000001106 230.0
TLS2_k127_2833863_0 Ribosomal protein S1 K02945 - - 2.411e-206 654.0
TLS2_k127_2833863_1 Protein similar to CwfJ C-terminus 1 K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000007114 188.0
TLS2_k127_2833863_2 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.0000000000000000000000000000000005128 136.0
TLS2_k127_2837247_0 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 507.0
TLS2_k127_2837247_1 Mediates zinc uptake. May also transport other divalent cations K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 351.0
TLS2_k127_2837247_2 Beta-lactamase class C and other penicillin binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001057 255.0
TLS2_k127_2837247_3 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000001256 146.0
TLS2_k127_2837247_4 Carboxypeptidase regulatory-like domain - - - 0.00000001956 58.0
TLS2_k127_2841883_0 Sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006285 377.0
TLS2_k127_2841883_1 PFAM Phenazine biosynthesis PhzC PhzF protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005848 329.0
TLS2_k127_2841883_2 PFAM ATP-binding region, ATPase domain protein domain protein K07683 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 308.0
TLS2_k127_2841883_3 PFAM Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003693 265.0
TLS2_k127_2841883_4 - - - - 0.0000000000000000000000000000000000000000000000000000000181 201.0
TLS2_k127_2844793_0 PFAM transposase IS4 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 451.0
TLS2_k127_2844793_1 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000008459 116.0
TLS2_k127_2844793_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000001073 100.0
TLS2_k127_2845196_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 3.252e-236 760.0
TLS2_k127_2845196_1 glycosyl transferase group 1 K00754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 400.0
TLS2_k127_2845196_2 ZIP Zinc transporter K16267 - - 0.000000000000000000000000000000000000000000000000000000000000004054 235.0
TLS2_k127_2845196_3 BON domain - - - 0.00000000000000000000000000000001906 133.0
TLS2_k127_2845196_4 selenocysteine insertion sequence binding - - - 0.000000000000000005297 83.0
TLS2_k127_2845196_5 Acetyltransferase (GNAT) domain - - - 0.0000000000000002083 87.0
TLS2_k127_2845196_6 Elongation factor SelB, winged helix K03833 - - 0.0000000004449 60.0
TLS2_k127_2845196_7 - - - - 0.0000184 48.0
TLS2_k127_2847729_0 symporter activity K03307 - - 5.631e-266 832.0
TLS2_k127_2847729_1 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003495 531.0
TLS2_k127_2847729_10 Pfam SNARE associated Golgi protein - - - 0.00000000000000000000003982 111.0
TLS2_k127_2847729_11 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000001423 110.0
TLS2_k127_2847729_12 - - - - 0.0000000000000000004101 100.0
TLS2_k127_2847729_13 bacterial OsmY and nodulation domain K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.0000000000005929 78.0
TLS2_k127_2847729_14 Acetyltransferase (GNAT) family - - - 0.000000004758 67.0
TLS2_k127_2847729_15 - - - - 0.00000005592 58.0
TLS2_k127_2847729_16 - - - - 0.00000007853 60.0
TLS2_k127_2847729_17 Domain of unknown function (DUF4440) - - - 0.0000000977 63.0
TLS2_k127_2847729_18 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000001267 53.0
TLS2_k127_2847729_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 509.0
TLS2_k127_2847729_3 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 490.0
TLS2_k127_2847729_4 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 465.0
TLS2_k127_2847729_5 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 462.0
TLS2_k127_2847729_6 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784,K12448 - 5.1.3.2,5.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 437.0
TLS2_k127_2847729_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004061 249.0
TLS2_k127_2847729_8 PFAM Peptidase M23 - - - 0.0000000000000000000000000000000000000000000000009391 186.0
TLS2_k127_2847729_9 - - - - 0.00000000000000000000000000000000000007917 149.0
TLS2_k127_2848774_0 Pyridoxal-dependent decarboxylase conserved domain K01593,K01634 - 4.1.1.105,4.1.1.28,4.1.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 553.0
TLS2_k127_2848774_1 Putative phosphatase (DUF442) - - - 0.00000000000001767 86.0
TLS2_k127_2848774_2 hyperosmotic response - - - 0.0000000002861 72.0
TLS2_k127_2848774_3 - - - - 0.0004618 50.0
TLS2_k127_2849095_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 527.0
TLS2_k127_2849095_1 PFAM glycosyl transferase family 9 K02841 - - 0.00000000000000000000000000000000000000000000000001528 192.0
TLS2_k127_2849095_2 Phospholipid methyltransferase - - - 0.0000000000000000007586 100.0
TLS2_k127_285043_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1136.0
TLS2_k127_285043_1 MutS domain I K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 5.079e-253 821.0
TLS2_k127_285043_10 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000006363 224.0
TLS2_k127_285043_11 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000002487 207.0
TLS2_k127_285043_12 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000004445 211.0
TLS2_k127_285043_13 Histidine kinase K13598 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000007988 225.0
TLS2_k127_285043_14 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000000000000000000000000000000006629 181.0
TLS2_k127_285043_15 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000001244 134.0
TLS2_k127_285043_16 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000000000000000000000000002076 126.0
TLS2_k127_285043_17 Universal bacterial protein YeaZ K14742 - - 0.00000000000000000000000004216 117.0
TLS2_k127_285043_18 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000001735 98.0
TLS2_k127_285043_19 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000007866 91.0
TLS2_k127_285043_2 MatE - - - 3.36e-215 678.0
TLS2_k127_285043_20 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.000000000000000002094 98.0
TLS2_k127_285043_21 PFAM response regulator receiver - - - 0.00000000000000002112 93.0
TLS2_k127_285043_22 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000001712 76.0
TLS2_k127_285043_24 Tetratricopeptide repeat - - - 0.000009677 56.0
TLS2_k127_285043_3 Protein kinase domain K12132 - 2.7.11.1 3.762e-209 683.0
TLS2_k127_285043_4 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 2.598e-208 664.0
TLS2_k127_285043_5 pseudouridine synthase activity K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 365.0
TLS2_k127_285043_6 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008048 387.0
TLS2_k127_285043_7 gluconate transmembrane transporter activity K03299 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 330.0
TLS2_k127_285043_8 Aminotransferase class I and II K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 326.0
TLS2_k127_285043_9 Deoxyhypusine synthase K00809 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000682 302.0
TLS2_k127_2858157_0 DNA topological change - - - 5.644e-248 795.0
TLS2_k127_2858157_1 long-chain fatty acid transporting porin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008039 546.0
TLS2_k127_2861296_0 Tricorn protease homolog K08676 - - 0.0 1038.0
TLS2_k127_2861296_1 Peptidase family M3 K01284 - 3.4.15.5 2.91e-301 940.0
TLS2_k127_2861296_10 - - - - 0.00000000000000000002269 95.0
TLS2_k127_2861296_11 Transcriptional regulatory protein, C terminal - - - 0.000000000000001141 82.0
TLS2_k127_2861296_2 TonB dependent receptor K16091 - - 6.252e-202 657.0
TLS2_k127_2861296_3 Alpha amylase, catalytic domain K01176,K01236 - 3.2.1.1,3.2.1.141 3.35e-198 638.0
TLS2_k127_2861296_4 Phospholipase D. Active site motifs. K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 520.0
TLS2_k127_2861296_5 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008894 457.0
TLS2_k127_2861296_6 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 452.0
TLS2_k127_2861296_7 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000226 260.0
TLS2_k127_2861296_8 PAS domain - - - 0.000000000000000000000000000000000001321 159.0
TLS2_k127_2861296_9 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000001828 100.0
TLS2_k127_2865270_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004388 237.0
TLS2_k127_2865270_1 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000001336 216.0
TLS2_k127_286795_0 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000000000000000002627 226.0
TLS2_k127_286795_1 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000002183 217.0
TLS2_k127_286795_2 - - - - 0.0000000000000000000000000000000000001425 146.0
TLS2_k127_286795_3 DNA topoisomerase (ATP-hydrolyzing) inhibitor activity K13652,K13653 - - 0.00000000000000000000000000000008196 136.0
TLS2_k127_2880231_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 409.0
TLS2_k127_2880231_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004646 317.0
TLS2_k127_2880231_2 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000000008755 219.0
TLS2_k127_2880231_3 Cytidine and deoxycytidylate deaminase zinc-binding region K01489 - 3.5.4.5 0.0000000000000000000000000000000000000000000378 171.0
TLS2_k127_2880231_4 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000103 113.0
TLS2_k127_2880231_5 NUDIX domain - - - 0.0004561 52.0
TLS2_k127_2921109_0 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 533.0
TLS2_k127_2921109_1 phosphorelay signal transduction system K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 478.0
TLS2_k127_2921109_10 23S rRNA-intervening sequence protein - - - 0.0000000000000000000000000004383 117.0
TLS2_k127_2921109_11 Pfam:N_methyl_2 - - - 0.00000000000000000004129 100.0
TLS2_k127_2921109_12 Pfam:N_methyl_2 - - - 0.000000000000001637 85.0
TLS2_k127_2921109_13 PFAM DSBA-like thioredoxin domain - - - 0.0000000000004062 81.0
TLS2_k127_2921109_2 Type II secretion system (T2SS), protein F K02455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 447.0
TLS2_k127_2921109_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003022 285.0
TLS2_k127_2921109_4 Sensor histidine kinase PilS, PAS domain-containing K02668,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000004867 285.0
TLS2_k127_2921109_5 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000003473 233.0
TLS2_k127_2921109_6 PFAM Type II secretion system protein E K02454,K02504,K02652 - - 0.00000000000000000000000000000000000000000000000000001034 191.0
TLS2_k127_2921109_7 - - - - 0.00000000000000000000000000000000000000000000000447 193.0
TLS2_k127_2921109_8 signal transduction histidine kinase K02668,K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000007809 187.0
TLS2_k127_2921109_9 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000004562 175.0
TLS2_k127_2921317_0 pfkB family carbohydrate kinase K00874 - 2.7.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006417 445.0
TLS2_k127_2921317_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008944 404.0
TLS2_k127_2921317_2 methionine sulfoxide reductase K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000944 213.0
TLS2_k127_2921317_3 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281,K12132 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0030145,GO:0034641,GO:0034654,GO:0043094,GO:0043167,GO:0043169,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.11.1,3.5.1.19 0.0000000000000000000000000000000000000000000000000000000000001795 217.0
TLS2_k127_2922271_0 Enoyl-(Acyl carrier protein) reductase K16216 - 1.1.1.320 0.00000000000000000000003036 109.0
TLS2_k127_2922271_1 Protein of unknown function (DUF3037) - - - 0.0000000000000000002331 89.0
TLS2_k127_2934966_0 PFAM glycoside hydrolase family 3 domain protein K05349 - 3.2.1.21 9.668e-237 747.0
TLS2_k127_2934966_1 Putative zinc- or iron-chelating domain - - - 0.000000000000001567 84.0
TLS2_k127_2937281_0 Heat shock 70 kDa protein K04043 - - 7.971e-285 886.0
TLS2_k127_2937281_1 Sugar-binding cellulase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005512 556.0
TLS2_k127_2937281_10 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.000000000000000000000000000000000014 141.0
TLS2_k127_2937281_11 bacterial (prokaryotic) histone like domain K03530 - - 0.00000000000000000000000002076 111.0
TLS2_k127_2937281_12 peptidase - - - 0.00000000000000000000001906 117.0
TLS2_k127_2937281_13 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000007681 104.0
TLS2_k127_2937281_14 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000002052 70.0
TLS2_k127_2937281_15 Hsp20/alpha crystallin family K13993 - - 0.00000000002429 72.0
TLS2_k127_2937281_16 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.0000000001126 69.0
TLS2_k127_2937281_17 TPR repeat-containing protein - - - 0.0000222 57.0
TLS2_k127_2937281_2 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 327.0
TLS2_k127_2937281_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007073 338.0
TLS2_k127_2937281_4 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001283 265.0
TLS2_k127_2937281_5 ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000227 256.0
TLS2_k127_2937281_6 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000002727 260.0
TLS2_k127_2937281_7 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000001592 238.0
TLS2_k127_2937281_8 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000008165 190.0
TLS2_k127_2937281_9 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000008191 158.0
TLS2_k127_2941104_0 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 445.0
TLS2_k127_2941104_1 lipopolysaccharide transport protein B ATP-binding component of ABC superfamily K01990,K06861 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 325.0
TLS2_k127_2941104_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 323.0
TLS2_k127_2941104_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 306.0
TLS2_k127_2941104_4 lipopolysaccharide transport K09774 - - 0.00000000000000000002464 107.0
TLS2_k127_2946433_0 choline dehydrogenase activity - - - 1.107e-209 667.0
TLS2_k127_2946433_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000003142 79.0
TLS2_k127_2946433_2 Gluconate 2-dehydrogenase subunit 3 - - - 0.00000000002293 71.0
TLS2_k127_2957124_0 alpha amylase catalytic K01182,K05343 - 3.2.1.1,3.2.1.10,5.4.99.16 0.0 1165.0
TLS2_k127_2957124_1 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004919 549.0
TLS2_k127_2957124_11 general secretion pathway protein - - - 0.00005188 48.0
TLS2_k127_2957124_2 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004431 415.0
TLS2_k127_2957124_3 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006308 330.0
TLS2_k127_2957124_4 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 308.0
TLS2_k127_2957124_5 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005633 284.0
TLS2_k127_2957124_6 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003057 244.0
TLS2_k127_2957124_7 protein conserved in bacteria - - - 0.00000000000000000000000000000000000004504 153.0
TLS2_k127_2957124_8 AAA domain - - - 0.000000000000000000004267 103.0
TLS2_k127_2957124_9 Helix-turn-helix XRE-family like proteins - - - 0.000002322 53.0
TLS2_k127_2958750_0 Histidine Phosphotransfer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 391.0
TLS2_k127_2958750_1 - - - - 0.00000000000000000000000000000000000000000005119 168.0
TLS2_k127_2962498_0 Trypsin-like peptidase domain K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000004816 195.0
TLS2_k127_2962498_1 PFAM regulatory protein LuxR - - - 0.00000000000000000000000000005382 124.0
TLS2_k127_2980633_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 3.701e-205 648.0
TLS2_k127_2980633_1 Sugar-binding cellulase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 553.0
TLS2_k127_2980633_2 Multicopper oxidase K22348 - 1.16.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 411.0
TLS2_k127_2980633_3 FAD dependent oxidoreductase K15736 - - 0.0000000000000000000000000000000003307 141.0
TLS2_k127_2986202_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 3.035e-317 981.0
TLS2_k127_3003948_0 Tetratricopeptide repeat K12132 - 2.7.11.1 2.651e-260 861.0
TLS2_k127_3003948_1 PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000512 541.0
TLS2_k127_3003948_2 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000003466 176.0
TLS2_k127_3003948_3 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000001105 122.0
TLS2_k127_3003948_4 BlaR1 peptidase M56 - - - 0.0002356 43.0
TLS2_k127_3006018_0 ASPIC and UnbV - - - 2.221e-286 907.0
TLS2_k127_3006018_1 Protein conserved in bacteria - - - 0.00000000000000000000000000006112 120.0
TLS2_k127_3006501_0 mandelate racemase muconate lactonizing K08323 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0047929,GO:0071704,GO:1901575 4.2.1.8 9.969e-204 643.0
TLS2_k127_3006501_1 Belongs to the glycosyl hydrolase 1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 595.0
TLS2_k127_3006501_2 Adenylate kinase K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 398.0
TLS2_k127_3006501_3 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009874 282.0
TLS2_k127_3006501_4 SnoaL-like polyketide cyclase - - - 0.000000000000000001995 94.0
TLS2_k127_3008818_0 PFAM FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000001564 205.0
TLS2_k127_3008818_1 NADH dehydrogenase K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000004077 192.0
TLS2_k127_3012633_0 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 8.028e-202 640.0
TLS2_k127_3012633_1 ATPase domain of DNA mismatch repair MUTS family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 587.0
TLS2_k127_3012633_10 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000001016 249.0
TLS2_k127_3012633_11 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000004623 227.0
TLS2_k127_3012633_12 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000002333 180.0
TLS2_k127_3012633_13 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000006206 139.0
TLS2_k127_3012633_14 Transcriptional regulator - - - 0.00000000000000000000000000000002183 135.0
TLS2_k127_3012633_15 proteolysis - - - 0.00000000000000000000000000000004008 141.0
TLS2_k127_3012633_16 Transporter, CPA2 family - - - 0.0001461 54.0
TLS2_k127_3012633_17 Trypsin K04771 - 3.4.21.107 0.0007096 52.0
TLS2_k127_3012633_2 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 464.0
TLS2_k127_3012633_3 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K11779,K11784,K18285 - 1.21.98.1,2.5.1.120,2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 456.0
TLS2_k127_3012633_4 Belongs to the cysteine synthase cystathionine beta- synthase family K12339,K21148 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.113,2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 400.0
TLS2_k127_3012633_5 abc-type fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006425 357.0
TLS2_k127_3012633_6 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 334.0
TLS2_k127_3012633_7 TonB-dependent Receptor Plug Domain K02014,K16092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006554 333.0
TLS2_k127_3012633_8 Diphthamide synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000977 294.0
TLS2_k127_3012633_9 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002066 271.0
TLS2_k127_3016040_0 Belongs to the IlvD Edd family K22396 - 4.2.1.82 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 319.0
TLS2_k127_3016040_1 ATPase activity K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001075 260.0
TLS2_k127_3016040_2 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000006119 138.0
TLS2_k127_3017930_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1182.0
TLS2_k127_3017930_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1112.0
TLS2_k127_3017930_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 586.0
TLS2_k127_3017930_3 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005031 403.0
TLS2_k127_3017930_4 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 406.0
TLS2_k127_3017930_5 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000007543 252.0
TLS2_k127_3017930_6 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.00000000000000000000000000000000000000000000000000000000000001095 228.0
TLS2_k127_3017930_7 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000001148 168.0
TLS2_k127_3017930_8 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000000000735 115.0
TLS2_k127_3019084_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00262 - 1.4.1.4 4.283e-221 690.0
TLS2_k127_3019084_1 Protein involved in outer membrane biogenesis - - - 0.000000000000000000000000000101 121.0
TLS2_k127_3034823_0 Carboxypeptidase regulatory-like domain - - - 4.787e-287 921.0
TLS2_k127_3034823_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000002482 197.0
TLS2_k127_3034823_2 deacetylase K01463 - - 0.0000000000000000000000000000000000000000002117 166.0
TLS2_k127_3034823_3 ASPIC and UnbV - - - 0.000000000442 61.0
TLS2_k127_3049909_0 Methionine synthase K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002689 519.0
TLS2_k127_3049909_1 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000001305 178.0
TLS2_k127_3051002_0 transport, permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 349.0
TLS2_k127_3051002_1 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007441 344.0
TLS2_k127_3051002_2 transport, permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 308.0
TLS2_k127_3051002_3 Outer membrane efflux protein - - - 0.0000000000000006091 84.0
TLS2_k127_3051002_4 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000007497 58.0
TLS2_k127_3052015_0 Protein of unknown function (DUF1501) - - - 1.576e-213 674.0
TLS2_k127_3052015_1 Concanavalin A-like lectin/glucanases superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 597.0
TLS2_k127_3052015_2 PFAM oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003168 265.0
TLS2_k127_3052015_3 - - - - 0.0000000000000000000000000000001828 132.0
TLS2_k127_3052020_0 Protein of unknown function (DUF763) K09003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 560.0
TLS2_k127_3052020_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002 233.0
TLS2_k127_3052020_2 protein conserved in bacteria K09955 - - 0.0000000000000002545 83.0
TLS2_k127_3052020_3 Acetyltransferase (GNAT) domain - - - 0.000001185 54.0
TLS2_k127_3058512_0 Amylo-alpha-1,6-glucosidase - - - 6.763e-211 679.0
TLS2_k127_3058512_1 gluconolactonase activity K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 607.0
TLS2_k127_3058512_2 PFAM Bacterial low temperature requirement A protein (LtrA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005533 265.0
TLS2_k127_3058512_3 Transport and Golgi organisation 2 K01755 - 4.3.2.1 0.00000000000000000000003491 108.0
TLS2_k127_3059441_0 efflux transmembrane transporter activity - - - 3.108e-194 636.0
TLS2_k127_3059441_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005424 612.0
TLS2_k127_3059441_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 507.0
TLS2_k127_3059441_3 PFAM intradiol ring-cleavage dioxygenase K00449 - 1.13.11.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 293.0
TLS2_k127_3059441_4 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K01838 - 5.4.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000006177 254.0
TLS2_k127_3059441_5 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000000000003165 175.0
TLS2_k127_3059441_6 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000000000006268 117.0
TLS2_k127_3059441_7 - - - - 0.00001497 53.0
TLS2_k127_3067849_0 Polysulphide reductase, NrfD K00185 - - 7.847e-234 732.0
TLS2_k127_3067849_1 Belongs to the heme-copper respiratory oxidase family K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009675 537.0
TLS2_k127_3067849_10 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000001114 220.0
TLS2_k127_3067849_11 Protein of unknown function (DUF3341) - - - 0.00000000000000000000000000000000000000000000000000000000002948 218.0
TLS2_k127_3067849_12 resistance ABC transporter ATPase subunit K01990,K18232 - - 0.0000000000000000000000000000000000000000000000000000003725 206.0
TLS2_k127_3067849_13 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000000000003304 200.0
TLS2_k127_3067849_14 protein tyrosine kinase activity K03593 - - 0.00000000000000000000000000000000000000003259 165.0
TLS2_k127_3067849_15 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000003945 137.0
TLS2_k127_3067849_16 Copper binding proteins, plastocyanin/azurin family - - - 0.000000000000000000000000000004371 126.0
TLS2_k127_3067849_18 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.0000000001335 74.0
TLS2_k127_3067849_19 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.0000003471 57.0
TLS2_k127_3067849_2 Proto-chlorophyllide reductase 57 kD subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 359.0
TLS2_k127_3067849_21 GCN5 family acetyltransferase - - - 0.0003212 53.0
TLS2_k127_3067849_3 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 351.0
TLS2_k127_3067849_4 Rubrerythrin K22405 - 1.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 336.0
TLS2_k127_3067849_5 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000872 335.0
TLS2_k127_3067849_6 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004525 277.0
TLS2_k127_3067849_7 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000009981 251.0
TLS2_k127_3067849_8 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000002746 250.0
TLS2_k127_3067849_9 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000004617 233.0
TLS2_k127_3071292_0 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 361.0
TLS2_k127_3071292_1 DinB family - - - 0.000000000000000000000411 99.0
TLS2_k127_3071292_2 Vitamin B12 dependent methionine synthase activation K00548 - 2.1.1.13 0.000000000000006068 75.0
TLS2_k127_3071292_3 23S rRNA-intervening sequence protein - - - 0.00003242 57.0
TLS2_k127_3073355_0 domain protein - - - 1.55e-295 944.0
TLS2_k127_3073355_1 Zinc carboxypeptidase - - - 5.261e-215 700.0
TLS2_k127_3073355_10 gtp cyclohydrolase K00950,K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000001272 263.0
TLS2_k127_3073355_11 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000111 238.0
TLS2_k127_3073355_12 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000002533 187.0
TLS2_k127_3073355_13 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000002496 167.0
TLS2_k127_3073355_14 TIGRFAM VWFA-related Acidobacterial domain - - - 0.0000000000000000000000000000000002844 152.0
TLS2_k127_3073355_15 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000008996 130.0
TLS2_k127_3073355_16 PFAM response regulator receiver - - - 0.0000000000000000000000001401 111.0
TLS2_k127_3073355_17 PFAM AIG2 family protein - - - 0.0000000000000000000182 98.0
TLS2_k127_3073355_18 Domain of unknown function (DUF4915) - - - 0.000000000000000001549 99.0
TLS2_k127_3073355_19 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.00000000000000006905 91.0
TLS2_k127_3073355_2 ASPIC and UnbV - - - 1.506e-212 673.0
TLS2_k127_3073355_20 - - - - 0.00000000000006282 83.0
TLS2_k127_3073355_21 ASPIC and UnbV - - - 0.0000006818 62.0
TLS2_k127_3073355_22 response K18444 - - 0.000172 49.0
TLS2_k127_3073355_3 PFAM LmbE family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 506.0
TLS2_k127_3073355_4 Belongs to the thiolase family K07508 - 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 439.0
TLS2_k127_3073355_5 Catalyzes the sodium-dependent transport of glutamate K03312 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 400.0
TLS2_k127_3073355_6 Dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007707 383.0
TLS2_k127_3073355_7 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000456 370.0
TLS2_k127_3073355_8 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 322.0
TLS2_k127_3073355_9 ATPase activity K01990,K19340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 336.0
TLS2_k127_3073724_0 helix_turn_helix isocitrate lyase regulation - - - 0.000000000004783 75.0
TLS2_k127_3097834_0 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 594.0
TLS2_k127_3097834_1 Protein of unknown function (DUF3500) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 314.0
TLS2_k127_3100010_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 7.578e-199 634.0
TLS2_k127_3100010_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007584 610.0
TLS2_k127_3100010_2 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 567.0
TLS2_k127_3100010_3 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 428.0
TLS2_k127_3100010_4 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 447.0
TLS2_k127_3100010_5 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000823 356.0
TLS2_k127_3100010_6 (AIR) carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005686 280.0
TLS2_k127_3100010_7 dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000001137 194.0
TLS2_k127_3100010_8 - - - - 0.000000000004423 69.0
TLS2_k127_3107729_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.538e-223 706.0
TLS2_k127_3107729_1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 526.0
TLS2_k127_3107729_2 Cobalamin B12-binding K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000002137 192.0
TLS2_k127_3107729_3 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000001716 136.0
TLS2_k127_3107729_4 Trehalose utilisation - - - 0.00000000000000000000000000000002248 142.0
TLS2_k127_3119163_0 Alpha-L-arabinofuranosidase C-terminus K01209 - 3.2.1.55 1.701e-194 622.0
TLS2_k127_3119163_1 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01739,K01761 - 2.5.1.48,4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 576.0
TLS2_k127_3119163_10 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000009776 268.0
TLS2_k127_3119163_11 ABC transporter substrate-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000009985 231.0
TLS2_k127_3119163_12 Cupin superfamily (DUF985) K09705 - - 0.0000000000000000000000000000000000000000000000000001119 192.0
TLS2_k127_3119163_13 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000001994 185.0
TLS2_k127_3119163_14 Sigma-70, region 4 type 2 - - - 0.0000000000000000000000000000000000000000000000003017 187.0
TLS2_k127_3119163_16 Histidine kinase K02480 - 2.7.13.3 0.0000000000000000000000000000000000000000000004713 183.0
TLS2_k127_3119163_18 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000001502 164.0
TLS2_k127_3119163_19 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000006986 125.0
TLS2_k127_3119163_2 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007894 465.0
TLS2_k127_3119163_20 Rhodanese Homology Domain K01069 - 3.1.2.6 0.000000000000000536 83.0
TLS2_k127_3119163_21 sulfuric ester hydrolase activity - - - 0.00000000000001273 88.0
TLS2_k127_3119163_22 - - - - 0.0000000000003345 79.0
TLS2_k127_3119163_23 - - - - 0.000000000004704 79.0
TLS2_k127_3119163_3 Tripartite tricarboxylate transporter TctA family K07793 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 434.0
TLS2_k127_3119163_4 Aldo Keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008458 416.0
TLS2_k127_3119163_5 DNA restriction-modification system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 425.0
TLS2_k127_3119163_6 BNR repeat-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 351.0
TLS2_k127_3119163_7 Xylose isomerase-like TIM barrel K03079 - 5.1.3.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 306.0
TLS2_k127_3119163_9 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000109 291.0
TLS2_k127_3123585_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 553.0
TLS2_k127_3123585_1 PFAM Uncharacterised BCR, COG1649 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 501.0
TLS2_k127_3123585_2 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008376 407.0
TLS2_k127_3123585_3 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 388.0
TLS2_k127_3123585_4 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 349.0
TLS2_k127_3123585_5 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005536 332.0
TLS2_k127_3123585_6 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002815 284.0
TLS2_k127_3123585_7 Domain of unknown function (DUF4154) - - - 0.000000000000000000000001122 117.0
TLS2_k127_3125238_0 PFAM LmbE family protein K22136 - - 1.469e-250 820.0
TLS2_k127_3125238_1 efflux transmembrane transporter activity - - - 1.233e-198 651.0
TLS2_k127_3125238_10 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000001227 137.0
TLS2_k127_3125238_11 Amino acid oxidase - - - 0.000000000000000000000000001054 128.0
TLS2_k127_3125238_12 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000004228 119.0
TLS2_k127_3125238_13 outer membrane efflux protein - - - 0.00000000003846 74.0
TLS2_k127_3125238_2 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007276 516.0
TLS2_k127_3125238_3 PFAM Integral membrane protein TerC K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007921 376.0
TLS2_k127_3125238_4 Sodium:solute symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 308.0
TLS2_k127_3125238_5 PFAM NAD dependent epimerase dehydratase family K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 303.0
TLS2_k127_3125238_6 ATPase activity K01990,K13926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000209 296.0
TLS2_k127_3125238_7 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001543 273.0
TLS2_k127_3125238_8 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000001158 233.0
TLS2_k127_3125238_9 HlyD family secretion protein K01993 - - 0.000000000000000000000000000000000000000000000003021 187.0
TLS2_k127_3173033_0 L-lactate permease K03303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009094 473.0
TLS2_k127_3173033_1 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 334.0
TLS2_k127_3173033_2 arylsulfatase activity - - - 0.0000000000000000000000000000007599 128.0
TLS2_k127_3196705_0 secondary active p-aminobenzoyl-glutamate transmembrane transporter activity K12942 - - 9.754e-206 651.0
TLS2_k127_3196705_1 Domain of unknown function (DUF5060) - - - 1.023e-203 661.0
TLS2_k127_3196705_10 Domain of unknown function (DUF4142) K08995 - - 0.0000000000000000000000003119 114.0
TLS2_k127_3196705_11 - - - - 0.000000000004794 68.0
TLS2_k127_3196705_12 peptidyl-tyrosine sulfation - - - 0.0000003981 63.0
TLS2_k127_3196705_13 Protein of unknown function (DUF1593) - - - 0.00003966 57.0
TLS2_k127_3196705_14 PFAM Endonuclease Exonuclease phosphatase - - - 0.00003974 55.0
TLS2_k127_3196705_2 Sodium/hydrogen exchanger family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 611.0
TLS2_k127_3196705_3 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 394.0
TLS2_k127_3196705_4 Belongs to the glycosyl hydrolase 43 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007185 354.0
TLS2_k127_3196705_5 protein deglycation K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 282.0
TLS2_k127_3196705_6 transferase activity, transferring glycosyl groups K12988,K18704 - 2.7.8.14,2.7.8.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001495 310.0
TLS2_k127_3196705_7 RNA methylase - - - 0.0000000000000000000000000000000000000000000000000000000000000009923 223.0
TLS2_k127_3196705_8 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000002024 248.0
TLS2_k127_3196705_9 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000004322 219.0
TLS2_k127_3198696_0 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) K00164 - 1.2.4.2 1.82e-233 738.0
TLS2_k127_32001_0 MTH538 TIR-like domain (DUF1863) K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000001174 221.0
TLS2_k127_3211961_0 ABC-type Fe3 transport system, permease component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008929 612.0
TLS2_k127_3211961_1 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 464.0
TLS2_k127_3211961_2 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 340.0
TLS2_k127_3211961_3 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004278 310.0
TLS2_k127_3211961_4 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002215 260.0
TLS2_k127_3211961_5 Glucose dehydrogenase C-terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002306 246.0
TLS2_k127_3211961_6 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000004672 227.0
TLS2_k127_3211961_7 DUF218 domain - - - 0.000000000000000006294 94.0
TLS2_k127_3237802_0 cytochrome p450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003909 262.0
TLS2_k127_3237802_1 AMP-binding enzyme C-terminal domain K00666 - - 0.000000000000000000000000000000000000000000000000000000008148 215.0
TLS2_k127_3237802_2 Phosphopantetheine attachment site - - - 0.0009972 45.0
TLS2_k127_3241914_0 PFAM sodium calcium exchanger K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 374.0
TLS2_k127_3241914_1 Malic enzyme, NAD binding domain K00027,K00029 - 1.1.1.38,1.1.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007887 290.0
TLS2_k127_3241914_2 esterase K07214 - - 0.000000000000000000000000000000000000000000000000000002435 192.0
TLS2_k127_3259608_0 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 532.0
TLS2_k127_3259608_1 ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 374.0
TLS2_k127_3259608_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 338.0
TLS2_k127_3259608_3 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005126 297.0
TLS2_k127_3259608_4 TIGRFAM efflux transporter, RND family, MFP subunit K02005 - - 0.0000000000000000000000000000000000000000000000000000000000006517 229.0
TLS2_k127_3259608_5 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000001947 221.0
TLS2_k127_3263816_0 TIGRFAM sulfate ABC transporter, periplasmic sulfate-binding protein K02048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 438.0
TLS2_k127_3263816_1 sulfate transport system, permease K02046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 372.0
TLS2_k127_3263816_2 Sulfate ABC transporter, inner membrane subunit CysW K02047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003635 317.0
TLS2_k127_3263816_3 PFAM Phosphate-selective porin O K07221 - - 0.0000000000000000000000000000000000000000000000000000000001562 214.0
TLS2_k127_3266148_0 Belongs to the short-chain dehydrogenases reductases (SDR) family K21883 - 1.1.1.401 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008908 349.0
TLS2_k127_3266148_1 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000007157 167.0
TLS2_k127_3267261_0 Belongs to the ompA family - - - 0.00000000000000000000000000000000002304 145.0
TLS2_k127_3267261_1 TIGRFAM VWFA-related Acidobacterial domain - - - 0.0000000000000000001183 100.0
TLS2_k127_3267261_2 TonB-dependent receptor - - - 0.0000000000000000002775 100.0
TLS2_k127_3267261_3 PFAM aminotransferase, class I and II - - - 0.00000000211 66.0
TLS2_k127_328065_0 Sigma-70 region 2 K03088 - - 0.0000000000000001236 87.0
TLS2_k127_328065_1 COG1131 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000005176 67.0
TLS2_k127_328065_2 Bacterial extracellular solute-binding protein K10117 - - 0.000926 52.0
TLS2_k127_3283056_0 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000298 209.0
TLS2_k127_3283056_1 Polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000105 112.0
TLS2_k127_3295522_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 3.17e-320 1003.0
TLS2_k127_3295522_1 PFAM TonB-dependent Receptor - - - 3.279e-222 714.0
TLS2_k127_3295522_11 Protein of unknown function (DUF1761) - - - 0.0000000000000001084 87.0
TLS2_k127_3295522_12 - K22014 - - 0.000000000000006421 78.0
TLS2_k127_3295522_13 Multicopper oxidase K00368,K22348 - 1.16.3.3,1.7.2.1 0.000009893 50.0
TLS2_k127_3295522_14 - - - - 0.00002772 56.0
TLS2_k127_3295522_2 Domain of Unknown Function (DUF1080) - - - 6.15e-202 638.0
TLS2_k127_3295522_3 histidine kinase A domain protein - - - 2.752e-200 649.0
TLS2_k127_3295522_4 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 494.0
TLS2_k127_3295522_5 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 404.0
TLS2_k127_3295522_6 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000961 288.0
TLS2_k127_3295522_7 Bacterial transcriptional repressor C-terminal - - - 0.0000000000000000000000000000000000000000000000000000004216 199.0
TLS2_k127_3295522_8 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000002918 175.0
TLS2_k127_3295522_9 Helix-turn-helix diphteria tox regulatory element K11924 - - 0.00000000000000000000000000000000000000004272 161.0
TLS2_k127_3296883_0 Sugar (and other) transporter - - - 4.87e-206 648.0
TLS2_k127_3296883_1 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 545.0
TLS2_k127_3296883_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006438 477.0
TLS2_k127_3296883_3 PAP2 superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005418 259.0
TLS2_k127_3296883_4 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000000001795 185.0
TLS2_k127_3298549_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 379.0
TLS2_k127_3298549_1 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008383 283.0
TLS2_k127_3298549_2 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005503 293.0
TLS2_k127_3298549_3 RNA polymerase sigma-54 factor K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003035 269.0
TLS2_k127_3298549_4 PTS system fructose IIA component K02793 - 2.7.1.191 0.00000000000000000000000000000000000005148 149.0
TLS2_k127_3298549_5 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.000000000000000000000001018 111.0
TLS2_k127_3298549_6 phosphocarrier protein HPr K11189 - - 0.0000000000000000003849 91.0
TLS2_k127_3299323_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 384.0
TLS2_k127_3299323_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005999 369.0
TLS2_k127_3299323_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006532 346.0
TLS2_k127_3310463_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 407.0
TLS2_k127_3310463_1 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000000144 164.0
TLS2_k127_3310463_2 - - - - 0.000000000000000000000421 105.0
TLS2_k127_3311451_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 477.0
TLS2_k127_3311451_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000984 455.0
TLS2_k127_3311451_10 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 288.0
TLS2_k127_3311451_11 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000001013 282.0
TLS2_k127_3311451_12 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000001171 278.0
TLS2_k127_3311451_13 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000000000000000001195 171.0
TLS2_k127_3311451_14 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000000000000000002787 154.0
TLS2_k127_3311451_15 Reverse transcriptase-like K02226,K22316 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 0.000000000000000000000000000000000000414 144.0
TLS2_k127_3311451_16 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000002951 129.0
TLS2_k127_3311451_17 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000002022 68.0
TLS2_k127_3311451_18 Essential cell division protein K03589 - - 0.000000005202 69.0
TLS2_k127_3311451_19 Evidence 5 No homology to any previously reported sequences - - - 0.000706 49.0
TLS2_k127_3311451_2 to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004064 430.0
TLS2_k127_3311451_3 Penicillin-binding Protein dimerisation domain K03587,K08384,K08724,K12552,K12556 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 430.0
TLS2_k127_3311451_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006142 416.0
TLS2_k127_3311451_5 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005623 399.0
TLS2_k127_3311451_6 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 370.0
TLS2_k127_3311451_7 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000514 351.0
TLS2_k127_3311451_8 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 345.0
TLS2_k127_3311451_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 301.0
TLS2_k127_3321214_0 Putative glucoamylase K01183 - 3.2.1.14 2.603e-287 900.0
TLS2_k127_3321214_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000003754 147.0
TLS2_k127_3321214_2 zinc-ribbon domain - - - 0.000001713 60.0
TLS2_k127_3339690_0 ASPIC and UnbV - - - 6.685e-208 664.0
TLS2_k127_3339690_1 Tetratricopeptide repeat - - - 0.000000000003803 73.0
TLS2_k127_3341520_0 FES K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001768 279.0
TLS2_k127_3341520_1 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000003768 235.0
TLS2_k127_3341520_2 Squalene/phytoene synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000221 227.0
TLS2_k127_3341520_3 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000001381 192.0
TLS2_k127_3341520_4 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.000000000000000000000000000000000000000000000000002994 195.0
TLS2_k127_3341520_5 thiolester hydrolase activity K06889 - - 0.000000000000000000000000000000000009713 154.0
TLS2_k127_3341520_6 squalene-associated FAD-dependent desaturase - - - 0.000000000000000000000006601 109.0
TLS2_k127_3341520_7 NUDIX domain - - - 0.000000000000000000000007544 114.0
TLS2_k127_3341520_8 MacB-like periplasmic core domain K02004 - - 0.000006093 48.0
TLS2_k127_3358215_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 551.0
TLS2_k127_3358215_1 phosphorelay signal transduction system K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 507.0
TLS2_k127_3358215_2 Multi-sensor signal transduction histidine kinase K07710 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 328.0
TLS2_k127_3358215_3 Surface antigen K07277,K09800 - - 0.00000000000000000000000000000002985 132.0
TLS2_k127_3358215_4 CAAX protease self-immunity - - - 0.000004961 57.0
TLS2_k127_3358215_5 - - - - 0.000502 52.0
TLS2_k127_3366156_0 The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system K02526 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 383.0
TLS2_k127_3366156_1 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000001075 215.0
TLS2_k127_3366156_2 Belongs to the PdxA family K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000213 53.0
TLS2_k127_3367950_0 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000001267 231.0
TLS2_k127_3370175_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.378e-236 743.0
TLS2_k127_3370175_1 Acyl-CoA dehydrogenase, C-terminal domain K16173 - 1.3.99.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 522.0
TLS2_k127_3370175_10 Belongs to the N(4) N(6)-methyltransferase family K00571,K00590 - 2.1.1.113,2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009041 332.0
TLS2_k127_3370175_11 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006969 319.0
TLS2_k127_3370175_12 Cytidylyltransferase K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006903 277.0
TLS2_k127_3370175_13 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000009607 215.0
TLS2_k127_3370175_14 Protein of unknown function (DUF2911) - - - 0.0000000000000000000000000000000000000000000000003368 181.0
TLS2_k127_3370175_15 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.000000000000000000000000000000000000000000000006154 194.0
TLS2_k127_3370175_16 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.00000000000000000000000000000000000000000002098 171.0
TLS2_k127_3370175_17 Belongs to the peptidase S11 family K01286,K07258,K07262 GO:0000003,GO:0000270,GO:0000910,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006022,GO:0006508,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016043,GO:0016787,GO:0019538,GO:0019954,GO:0022402,GO:0022414,GO:0030203,GO:0032505,GO:0042221,GO:0042493,GO:0042597,GO:0043093,GO:0043170,GO:0044238,GO:0044464,GO:0045229,GO:0050896,GO:0051301,GO:0070011,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901564 3.4.16.4 0.000000000000000000000000000000000000000000089 174.0
TLS2_k127_3370175_18 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000006986 149.0
TLS2_k127_3370175_19 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.00000000000000000000000000000000000003165 158.0
TLS2_k127_3370175_2 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 461.0
TLS2_k127_3370175_20 O-methyltransferase - - - 0.00000000000000000000000000000008928 134.0
TLS2_k127_3370175_21 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000001196 123.0
TLS2_k127_3370175_22 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446,K11532 - 3.1.3.11,3.1.3.37 0.00000000000000000000000002258 110.0
TLS2_k127_3370175_23 oxidoreductase activity - - - 0.0000000000000000001196 103.0
TLS2_k127_3370175_24 Necessary for formate dehydrogenase activity K02380 - - 0.00000000000000007426 91.0
TLS2_k127_3370175_25 DinB superfamily - - - 0.0000000000000003378 89.0
TLS2_k127_3370175_26 methyltransferase - - - 0.000001047 59.0
TLS2_k127_3370175_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 412.0
TLS2_k127_3370175_4 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671,K22345 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9,4.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 391.0
TLS2_k127_3370175_5 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003696 368.0
TLS2_k127_3370175_6 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006836 375.0
TLS2_k127_3370175_7 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 364.0
TLS2_k127_3370175_8 Arginase family K01476 - 3.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009326 351.0
TLS2_k127_3370175_9 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 339.0
TLS2_k127_3372564_0 Copper amine oxidase, N2 domain K00276 - 1.4.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 439.0
TLS2_k127_3381392_0 efflux transmembrane transporter activity K02004 - - 2.513e-251 799.0
TLS2_k127_3381392_1 GDSL-like lipase acylhydrolase domain protein - - - 0.0000000789 55.0
TLS2_k127_3381408_0 PFAM Radical SAM - - - 4.104e-217 687.0
TLS2_k127_3381408_1 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000005741 217.0
TLS2_k127_3381408_2 Copper amine oxidase, N2 domain K00276 - 1.4.3.21 0.0000000000000000000000000000000000000003589 150.0
TLS2_k127_341044_0 Aldo Keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006607 313.0
TLS2_k127_3416689_0 Carboxypeptidase regulatory-like domain - - - 1.739e-249 808.0
TLS2_k127_3457420_0 Sulfite reductase K00366,K00381,K00392 - 1.7.7.1,1.8.1.2,1.8.7.1 3.618e-227 719.0
TLS2_k127_3457420_1 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 456.0
TLS2_k127_3457420_10 Belongs to the PAPS reductase family. CysH subfamily K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000004454 269.0
TLS2_k127_3457420_11 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000001557 271.0
TLS2_k127_3457420_12 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000001462 232.0
TLS2_k127_3457420_13 tRNA m6t6A37 methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000007855 218.0
TLS2_k127_3457420_14 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000005019 201.0
TLS2_k127_3457420_15 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000001636 188.0
TLS2_k127_3457420_16 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000005432 172.0
TLS2_k127_3457420_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 394.0
TLS2_k127_3457420_3 Putative serine dehydratase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 352.0
TLS2_k127_3457420_4 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 352.0
TLS2_k127_3457420_5 PFAM Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 309.0
TLS2_k127_3457420_6 Oxidoreductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 310.0
TLS2_k127_3457420_7 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 315.0
TLS2_k127_3457420_8 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 296.0
TLS2_k127_3457420_9 PFAM peptidase S58, DmpA K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002404 282.0
TLS2_k127_3546701_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 496.0
TLS2_k127_3546701_1 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 297.0
TLS2_k127_3546701_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.00000000000000000000000000000000000000001733 166.0
TLS2_k127_3546701_3 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000001258 133.0
TLS2_k127_3546701_4 - - - - 0.00000000000000000000003122 103.0
TLS2_k127_3546701_5 - - - - 0.000000000000003027 81.0
TLS2_k127_3546701_6 TIGRFAM VWFA-related Acidobacterial domain - - - 0.00000000006788 66.0
TLS2_k127_3546701_7 Predicted membrane protein (DUF2085) - - - 0.000002652 56.0
TLS2_k127_3546701_8 - - - - 0.00001654 53.0
TLS2_k127_3563727_0 MacB-like periplasmic core domain - - - 5.854e-197 645.0
TLS2_k127_3563727_1 phosphate symporter K14683 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007983 282.0
TLS2_k127_3563727_2 PhoU domain - - - 0.0000000000000006396 88.0
TLS2_k127_3563727_3 tRNA synthetases class I (E and Q), catalytic domain K01894 - - 0.0002263 45.0
TLS2_k127_3634466_0 associated with various cellular activities K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 347.0
TLS2_k127_3634466_1 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 315.0
TLS2_k127_3634466_2 Putative glutamine amidotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001493 293.0
TLS2_k127_3634466_3 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003703 274.0
TLS2_k127_3634466_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004086 250.0
TLS2_k127_3634466_5 PFAM Rhomboid family protein - - - 0.0000000000000000000000000000000000000005579 168.0
TLS2_k127_3634466_6 oxidoreductase activity - - - 0.000000000000000000000000000000000001969 158.0
TLS2_k127_3634466_7 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000000000000000000001502 139.0
TLS2_k127_365276_0 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 367.0
TLS2_k127_365276_1 pfkB family carbohydrate kinase K00874 - 2.7.1.45 0.000000001596 60.0
TLS2_k127_3728048_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 1.438e-203 642.0
TLS2_k127_3728048_1 PFAM glycoside hydrolase family 29 K01206 - 3.2.1.51 2.707e-199 634.0
TLS2_k127_3728048_2 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 484.0
TLS2_k127_3728048_3 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000596 293.0
TLS2_k127_3728048_4 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001219 287.0
TLS2_k127_3728048_5 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005726 265.0
TLS2_k127_3728048_6 COGs COG2905 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.00000000000000000000000000000000000000000008833 163.0
TLS2_k127_3728048_7 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000002981 88.0
TLS2_k127_3728048_8 - - - - 0.0001919 53.0
TLS2_k127_3730593_0 Iron-containing alcohol dehydrogenase K11173 - 1.1.99.24 1.087e-213 669.0
TLS2_k127_3730593_1 Oxidoreductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 438.0
TLS2_k127_3730593_2 alcohol dehydrogenase K13979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005338 436.0
TLS2_k127_3730593_3 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004912 295.0
TLS2_k127_3730593_4 WD40 domain protein beta Propeller - - - 0.00000000000000000000000000000000000000277 160.0
TLS2_k127_3730593_5 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000003859 153.0
TLS2_k127_3730593_6 Glycosyl transferase, family 2 K00721,K07011,K20444 - 2.4.1.83 0.000000000000000000000000002663 127.0
TLS2_k127_374062_0 methyl-accepting chemotaxis protein K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004473 271.0
TLS2_k127_374062_1 PFAM Glycosyl transferase family 2 - - - 0.000000007438 57.0
TLS2_k127_374062_2 Putative MetA-pathway of phenol degradation - - - 0.00009279 54.0
TLS2_k127_3747005_0 Belongs to the GSP D family K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000408 315.0
TLS2_k127_3747005_1 PFAM SAF domain K02279 - - 0.00000000000000000000000000000000000000000000001225 181.0
TLS2_k127_3748170_0 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 9.702e-241 765.0
TLS2_k127_3748170_1 Phosphate acyltransferases K01897 - 6.2.1.3 9.645e-235 751.0
TLS2_k127_3748170_10 ATP:ADP antiporter activity K03301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003906 295.0
TLS2_k127_3748170_11 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000592 270.0
TLS2_k127_3748170_12 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000003109 214.0
TLS2_k127_3748170_13 Domain present in phytochromes and cGMP-specific phosphodiesterases. K08968 - 1.8.4.14 0.0000000000000000000000000000000000007513 151.0
TLS2_k127_3748170_14 phosphoprotein phosphatase activity K14680 - 6.5.1.3 0.0000000000000000000000000000000004009 142.0
TLS2_k127_3748170_15 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000006485 120.0
TLS2_k127_3748170_16 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.00000000000000000000001866 114.0
TLS2_k127_3748170_17 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000001342 93.0
TLS2_k127_3748170_2 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 438.0
TLS2_k127_3748170_3 PFAM CBS domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 421.0
TLS2_k127_3748170_4 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 387.0
TLS2_k127_3748170_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 337.0
TLS2_k127_3748170_6 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 304.0
TLS2_k127_3748170_7 Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 314.0
TLS2_k127_3748170_8 succinyl-diaminopimelate desuccinylase activity K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 300.0
TLS2_k127_3748170_9 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001004 289.0
TLS2_k127_3759157_0 secretion system protein K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 524.0
TLS2_k127_3759157_1 AAA domain K02282 - - 0.0000000000000000000000000000000000000000003998 172.0
TLS2_k127_3759157_2 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000000000000002169 146.0
TLS2_k127_3763805_0 Flavin containing amine oxidoreductase - - - 1.05e-231 728.0
TLS2_k127_3763805_1 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 523.0
TLS2_k127_3763805_2 TIGRFAM phytoene desaturase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 484.0
TLS2_k127_3763805_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0003748 51.0
TLS2_k127_3773768_0 PFAM Acetyl-CoA hydrolase transferase K01067 - 3.1.2.1 1.958e-208 660.0
TLS2_k127_3773768_1 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006259 475.0
TLS2_k127_3773768_2 COG0534 Na -driven multidrug efflux pump K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 444.0
TLS2_k127_3773768_3 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 441.0
TLS2_k127_3773768_4 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005586 333.0
TLS2_k127_3773768_5 TonB-dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002928 310.0
TLS2_k127_3773768_6 Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004078 279.0
TLS2_k127_3773768_7 major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000001992 194.0
TLS2_k127_3773768_8 Ferredoxin K00529,K04755,K08952,K08953,K08954,K15765 GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858 1.18.1.3 0.0000000000000000000000000000000000000006118 164.0
TLS2_k127_3773768_9 DinB superfamily - - - 0.000000000007552 68.0
TLS2_k127_3775963_0 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second K01958 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.1 0.0 1020.0
TLS2_k127_3775963_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000004534 233.0
TLS2_k127_3775963_2 CDP-alcohol phosphatidyltransferase - - - 0.000000000000000000000000000000000000000000000000000002735 200.0
TLS2_k127_3775963_3 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000001942 190.0
TLS2_k127_3779591_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 2.868e-245 768.0
TLS2_k127_3779591_1 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 572.0
TLS2_k127_3779591_10 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000002088 233.0
TLS2_k127_3779591_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000001051 239.0
TLS2_k127_3779591_12 Pfam:UPF0118 - - - 0.0000000000000000000000000000000000000000000000000000000000001681 231.0
TLS2_k127_3779591_13 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000000008117 199.0
TLS2_k127_3779591_14 HlyD family secretion protein - - - 0.00000000000000000000000000000000000000000000000000003668 213.0
TLS2_k127_3779591_15 protein domain associated with K03595,K06883,K06946 - - 0.0000000000000000000000000000000000000000000000000006674 196.0
TLS2_k127_3779591_16 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000005378 201.0
TLS2_k127_3779591_17 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000005936 179.0
TLS2_k127_3779591_18 HlyD family secretion protein - - - 0.000000000000000000000000000000000000000000004536 180.0
TLS2_k127_3779591_19 Serine Threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000002967 167.0
TLS2_k127_3779591_2 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 554.0
TLS2_k127_3779591_20 Heparinase II/III-like protein - - - 0.000000000000000000000000000000000002614 160.0
TLS2_k127_3779591_21 HNH endonuclease - - - 0.000000000000000000000000000000000004864 140.0
TLS2_k127_3779591_22 - - - - 0.00000000000000000000000003331 125.0
TLS2_k127_3779591_23 amidohydrolase K22213 - 4.1.1.52 0.0000000000000000000000005411 115.0
TLS2_k127_3779591_24 Globin - - - 0.0000000000000000000008035 113.0
TLS2_k127_3779591_25 Periplasmic component of the Tol biopolymer transport system - - - 0.000000000000008597 88.0
TLS2_k127_3779591_26 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000004509 82.0
TLS2_k127_3779591_28 Domain in cystathionine beta-synthase and other proteins. - - - 0.000007568 55.0
TLS2_k127_3779591_29 OprF membrane domain K03286 - - 0.00006235 53.0
TLS2_k127_3779591_3 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 537.0
TLS2_k127_3779591_4 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000278 526.0
TLS2_k127_3779591_5 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 450.0
TLS2_k127_3779591_6 Selenocysteine lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009817 436.0
TLS2_k127_3779591_7 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 310.0
TLS2_k127_3779591_8 Heparinase II/III N-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 311.0
TLS2_k127_3779591_9 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001388 297.0
TLS2_k127_3784784_0 Glycosyl hydrolases family 43 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008126 464.0
TLS2_k127_3784784_1 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009494 414.0
TLS2_k127_3784784_2 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 386.0
TLS2_k127_3784784_3 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000000325 151.0
TLS2_k127_3784784_4 von Willebrand factor, type A - - - 0.0000000000000000000000000006129 128.0
TLS2_k127_3784784_5 SnoaL-like domain - - - 0.000000000000000000003126 99.0
TLS2_k127_3784784_6 Cupin 2, conserved barrel domain protein K16953,K19547 - 4.4.1.3,5.3.3.19 0.00001225 51.0
TLS2_k127_3784784_7 Cupin 2, conserved barrel domain protein - - - 0.0001065 48.0
TLS2_k127_3784784_8 Protein tyrosine kinase - - - 0.0006667 44.0
TLS2_k127_3786625_0 FCD - - - 0.0000000000000000000000000000000000000000000000000000000005217 209.0
TLS2_k127_3786625_1 and related - - - 0.00000000000000000000000000000000000000000000000000002082 203.0
TLS2_k127_3786625_2 DoxX K16937 - 1.8.5.2 0.00000000000000000000000000004509 124.0
TLS2_k127_3786891_0 synthase K00705,K06044 GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 2.748e-235 751.0
TLS2_k127_3786891_1 Bacterial regulatory protein, Fis family K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008356 350.0
TLS2_k127_3786891_2 Dihydrodipicolinate reductase, N-terminus K21672 - 1.4.1.12,1.4.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000001833 271.0
TLS2_k127_3787157_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006507 293.0
TLS2_k127_3787157_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000168 274.0
TLS2_k127_3787157_10 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000003986 97.0
TLS2_k127_3787157_11 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000009691 96.0
TLS2_k127_3787157_12 Ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000001109 74.0
TLS2_k127_3787157_13 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000001048 61.0
TLS2_k127_3787157_2 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.0000000000000000000000000000000000000000000000000000000000000000001476 231.0
TLS2_k127_3787157_3 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000003045 215.0
TLS2_k127_3787157_4 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001871 204.0
TLS2_k127_3787157_5 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.00000000000000000000000000000000000000000000000000000246 195.0
TLS2_k127_3787157_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000001077 176.0
TLS2_k127_3787157_7 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000001201 166.0
TLS2_k127_3787157_8 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000002964 147.0
TLS2_k127_3787157_9 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000003149 112.0
TLS2_k127_3787771_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 301.0
TLS2_k127_3787771_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000000000000000000000000000000000000000000003319 201.0
TLS2_k127_3803980_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 5.544e-219 696.0
TLS2_k127_3803980_1 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000008517 87.0
TLS2_k127_3805568_0 Beta-galactosidase trimerisation domain K12308 - 3.2.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 515.0
TLS2_k127_3805568_1 Glycosyl hydrolases family 43 - - - 0.000000000000002865 86.0
TLS2_k127_3816241_0 Amidohydrolase family - - - 0.0 1176.0
TLS2_k127_3816241_1 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002195 299.0
TLS2_k127_3816241_2 endonuclease III K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000008305 199.0
TLS2_k127_3816241_3 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000007272 175.0
TLS2_k127_3816241_4 COG0720 6-pyruvoyl-tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000005593 167.0
TLS2_k127_3816241_5 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000001519 151.0
TLS2_k127_3816241_6 HAD-hyrolase-like K01091 - 3.1.3.18 0.000000000000000000000000000000000005017 145.0
TLS2_k127_3816241_7 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000002103 96.0
TLS2_k127_3816241_8 Membrane K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000006169 96.0
TLS2_k127_3817299_0 Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system K10441 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006712 438.0
TLS2_k127_3817299_1 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009729 406.0
TLS2_k127_3817299_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 362.0
TLS2_k127_3817299_3 Periplasmic binding protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 298.0
TLS2_k127_3817299_4 Phosphogluconate dehydrogenase (decarboxylating) C-term - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002107 286.0
TLS2_k127_3817299_5 Branched-chain amino acid transport system / permease component K10440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002426 259.0
TLS2_k127_3817299_6 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000001584 94.0
TLS2_k127_3818185_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 420.0
TLS2_k127_3818185_1 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008992 385.0
TLS2_k127_3818185_2 DNA integration - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006124 342.0
TLS2_k127_3818185_3 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.00000000000000000000000000000000000000000000000000000001439 203.0
TLS2_k127_3818185_4 DNA primase - - - 0.000000000000000000000000000000000000003288 166.0
TLS2_k127_3818185_5 MoeA N-terminal region (domain I and II) K03750,K07219 - 2.10.1.1 0.0000000000000000000000000000000000002529 152.0
TLS2_k127_3822918_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006643 546.0
TLS2_k127_3822918_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000005802 195.0
TLS2_k127_3822918_2 - - - - 0.00000000000000000000000000000000000000004182 164.0
TLS2_k127_3822918_3 - - - - 0.000000000000000001698 89.0
TLS2_k127_3823906_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0 1881.0
TLS2_k127_3823906_1 Major facilitator superfamily K06610,K08369 - - 5.284e-210 660.0
TLS2_k127_3823906_2 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 439.0
TLS2_k127_3829516_0 Belongs to the PEP-utilizing enzyme family K01006,K22424 - 2.7.3.13,2.7.9.1 0.0 1098.0
TLS2_k127_3829516_1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 1.42e-264 829.0
TLS2_k127_3829516_10 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 384.0
TLS2_k127_3829516_11 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 370.0
TLS2_k127_3829516_12 Ankyrin repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 347.0
TLS2_k127_3829516_13 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 324.0
TLS2_k127_3829516_14 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 319.0
TLS2_k127_3829516_15 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 311.0
TLS2_k127_3829516_16 Transporter associated domain K06189 - - 0.000000000000000000000000000000000000000000000000000000000000000007135 243.0
TLS2_k127_3829516_17 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000000000001695 213.0
TLS2_k127_3829516_18 NDK K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.000000000000000000000000000000000000000000000000000007962 198.0
TLS2_k127_3829516_19 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000001618 120.0
TLS2_k127_3829516_2 L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp K01876 - 6.1.1.12 3.999e-205 655.0
TLS2_k127_3829516_20 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000009185 113.0
TLS2_k127_3829516_21 Protein of unknown function (DUF2905) - - - 0.000000000007308 68.0
TLS2_k127_3829516_22 Metallo-beta-lactamase superfamily - - - 0.00000000003865 68.0
TLS2_k127_3829516_3 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 510.0
TLS2_k127_3829516_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 509.0
TLS2_k127_3829516_5 PFAM tRNA synthetase class II (G H P and S) K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003869 443.0
TLS2_k127_3829516_6 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004155 417.0
TLS2_k127_3829516_7 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 422.0
TLS2_k127_3829516_8 Acts as a magnesium transporter K03281,K04767,K06213,K15986 GO:0000287,GO:0003674,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015693,GO:0030001,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0070838,GO:0072511 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 407.0
TLS2_k127_3829516_9 PFAM PhoH family protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 389.0
TLS2_k127_3839444_0 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001089 258.0
TLS2_k127_3839444_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000007893 211.0
TLS2_k127_3839444_2 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000000000000000000000000000000000004473 196.0
TLS2_k127_3839444_3 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.0000000000000000000000000000000000000000000000003006 183.0
TLS2_k127_3839444_4 methyltransferase - - - 0.00000000000000000000000001531 119.0
TLS2_k127_3839444_5 - - - - 0.000000000000005312 85.0
TLS2_k127_3839444_6 Belongs to the LarC family K09121 - 4.99.1.12 0.000000004265 57.0
TLS2_k127_3851408_0 peptidyl-tyrosine sulfation K01277 - 3.4.14.4 8.756e-262 824.0
TLS2_k127_3851408_1 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K11177 - 1.17.1.4 5.47e-209 672.0
TLS2_k127_3851408_10 PFAM Peptidase M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005682 276.0
TLS2_k127_3851408_11 PFAM molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000001347 268.0
TLS2_k127_3851408_12 Potassium uptake protein K03499 - - 0.00000000000000000000000000000000000000000000000000000000000114 219.0
TLS2_k127_3851408_13 Short-chain dehydrogenase reductase SDR K03793 - 1.5.1.33 0.000000000000000000000000000000000000000000000000001028 192.0
TLS2_k127_3851408_14 2Fe-2S -binding K13483 - - 0.00000000000000000000000000000000000000000000000003316 203.0
TLS2_k127_3851408_15 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000006282 138.0
TLS2_k127_3851408_16 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000002289 117.0
TLS2_k127_3851408_17 - - - - 0.000000000000000004908 95.0
TLS2_k127_3851408_18 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07715 - - 0.0000000000007641 74.0
TLS2_k127_3851408_2 peptidase S9B dipeptidylpeptidase IV domain protein K01278 - 3.4.14.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 587.0
TLS2_k127_3851408_20 protein kinase activity - - - 0.0001148 55.0
TLS2_k127_3851408_21 Carboxypeptidase regulatory-like domain - - - 0.0002935 50.0
TLS2_k127_3851408_22 - - - - 0.00062 52.0
TLS2_k127_3851408_3 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 532.0
TLS2_k127_3851408_4 Beta-Casp domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 486.0
TLS2_k127_3851408_5 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 394.0
TLS2_k127_3851408_6 PFAM Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 366.0
TLS2_k127_3851408_7 Potassium uptake protein TrkH family K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 377.0
TLS2_k127_3851408_8 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009918 299.0
TLS2_k127_3851408_9 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006237 285.0
TLS2_k127_3858192_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 364.0
TLS2_k127_3858192_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000833 299.0
TLS2_k127_3858192_2 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000004239 206.0
TLS2_k127_3858192_3 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.0000000000000000000000000000000182 142.0
TLS2_k127_3867248_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 348.0
TLS2_k127_3867248_1 Alpha-L-rhamnosidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009787 335.0
TLS2_k127_3867248_2 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000001794 212.0
TLS2_k127_3867248_3 Bacterial PH domain - - - 0.000000000000000000000000000000000001839 142.0
TLS2_k127_3867248_4 Cysteine-rich secretory protein family - - - 0.00000000000000000000001689 110.0
TLS2_k127_3875684_0 Rhodanese Homology Domain K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008769 454.0
TLS2_k127_3875684_1 Domain of unknown function (DUF4342) - - - 0.0000000000000000000176 93.0
TLS2_k127_3890092_0 Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs K05544 - 1.3.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000008858 259.0
TLS2_k127_3890092_1 - - - - 0.000000000001074 79.0
TLS2_k127_3914425_0 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 372.0
TLS2_k127_3914425_1 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000001483 172.0
TLS2_k127_3914425_2 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000006888 146.0
TLS2_k127_3923227_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 1.106e-201 662.0
TLS2_k127_3923227_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 573.0
TLS2_k127_3923227_10 photosystem II stabilization K00703,K02237,K02238 - 2.4.1.21 0.0000000000000001156 85.0
TLS2_k127_3923227_11 - - - - 0.000000000000002288 78.0
TLS2_k127_3923227_2 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006888 537.0
TLS2_k127_3923227_3 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 413.0
TLS2_k127_3923227_4 Polysaccharide biosynthesis protein K01784,K02473 - 5.1.3.2,5.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009554 366.0
TLS2_k127_3923227_5 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006304 350.0
TLS2_k127_3923227_6 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 328.0
TLS2_k127_3923227_7 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003836 295.0
TLS2_k127_3923227_8 Belongs to the peptidase S8 family K14645 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003266 265.0
TLS2_k127_3923227_9 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000134 235.0
TLS2_k127_3937145_0 TonB-dependent Receptor Plug Domain - - - 7.101e-292 932.0
TLS2_k127_3937145_1 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 551.0
TLS2_k127_3937145_2 - - - - 0.00000000000000000000000000000000000000000000000000000004229 208.0
TLS2_k127_3937145_3 - - - - 0.0000000000000000000000000000000124 130.0
TLS2_k127_3944300_0 COG0457 FOG TPR repeat - - - 7.144e-260 814.0
TLS2_k127_3944300_1 AbgT putative transporter family K12942 - - 4.785e-219 690.0
TLS2_k127_3944300_10 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000001069 156.0
TLS2_k127_3944300_11 YCII-related domain - - - 0.0000000000000000000000000000000003299 136.0
TLS2_k127_3944300_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 549.0
TLS2_k127_3944300_3 PFAM FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 492.0
TLS2_k127_3944300_4 belongs to the sigma-70 factor family K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 424.0
TLS2_k127_3944300_5 Belongs to the peptidase M16 family K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 339.0
TLS2_k127_3944300_6 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 305.0
TLS2_k127_3944300_7 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000003791 260.0
TLS2_k127_3944300_8 PFAM peptidase M16 domain protein K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002116 274.0
TLS2_k127_3944300_9 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000000000001952 187.0
TLS2_k127_3951169_0 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 523.0
TLS2_k127_3951169_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 531.0
TLS2_k127_3951169_10 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000000000000449 80.0
TLS2_k127_3951169_11 ZIP Zinc transporter K07238 - - 0.00000001835 55.0
TLS2_k127_3951169_2 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007974 457.0
TLS2_k127_3951169_3 Enoyl-(Acyl carrier protein) reductase K18335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 346.0
TLS2_k127_3951169_4 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000002547 190.0
TLS2_k127_3951169_5 Protein of unknown function (DUF1440) K08996 - - 0.00000000000000000005212 98.0
TLS2_k127_3951169_7 PFAM sigma-70 region 2 domain protein K03088 - - 0.0000000000000000002526 94.0
TLS2_k127_3951169_8 Protein of unknown function (DUF3618) - - - 0.0000000000000001023 94.0
TLS2_k127_3951169_9 - - - - 0.0000000000000001379 88.0
TLS2_k127_3959273_0 Belongs to the aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 501.0
TLS2_k127_3959273_1 Tartrate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 326.0
TLS2_k127_3975571_0 PFAM Radical SAM - - - 0.0 1072.0
TLS2_k127_3975571_1 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006462 531.0
TLS2_k127_3975571_2 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008499 396.0
TLS2_k127_3975571_3 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 339.0
TLS2_k127_3975571_4 PIN domain - - - 0.000000000000000000000000000000000000000002206 164.0
TLS2_k127_3975571_5 positive regulation of growth K01081 - 3.1.3.5 0.000000003017 67.0
TLS2_k127_39806_0 Glycosyl hydrolase family 57 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 566.0
TLS2_k127_39806_1 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 430.0
TLS2_k127_39806_10 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000008936 246.0
TLS2_k127_39806_11 chromosome segregation K03497 - - 0.0000000000000000000000000000000000000000000000000000000000001431 221.0
TLS2_k127_39806_12 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000343 212.0
TLS2_k127_39806_13 MotA TolQ ExbB proton channel K03562 - - 0.0000000000000000000000000000000000000000000000000000004459 203.0
TLS2_k127_39806_14 Type ii and iii secretion system protein K02453 - - 0.000000000000000000000000000000000000000000000000000001626 211.0
TLS2_k127_39806_15 BadF BadG BcrA BcrD ATPase family - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000005248 185.0
TLS2_k127_39806_16 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000000000000000003667 168.0
TLS2_k127_39806_17 amine dehydrogenase activity K00504,K12132 - 1.14.17.3,2.7.11.1 0.0000000000000000000000000000000000001857 156.0
TLS2_k127_39806_18 PFAM OmpA MotB domain protein K03640 - - 0.0000000000000000000000000000000004758 142.0
TLS2_k127_39806_19 PHP domain protein - - - 0.000000000000000000000000000000009411 146.0
TLS2_k127_39806_2 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 418.0
TLS2_k127_39806_20 type II secretion system protein G K02456 - - 0.0000000000000000000000000000009674 132.0
TLS2_k127_39806_21 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000309 125.0
TLS2_k127_39806_22 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.0000000000000000000001508 104.0
TLS2_k127_39806_23 Outer membrane lipoprotein - - - 0.00000000000000001001 94.0
TLS2_k127_39806_24 negative regulation of transcription, DNA-templated - - - 0.00000000001192 70.0
TLS2_k127_39806_25 Type II secretory pathway, pseudopilin - - - 0.0000000006608 72.0
TLS2_k127_39806_26 TonB C terminal K03832 - - 0.000000004807 66.0
TLS2_k127_39806_27 Bacterial Ig-like domain (group 1) - - - 0.0000283 56.0
TLS2_k127_39806_3 Permease YjgP YjgQ family protein K07091,K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 414.0
TLS2_k127_39806_4 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 359.0
TLS2_k127_39806_5 Cobyrinic acid ac-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 295.0
TLS2_k127_39806_6 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008783 276.0
TLS2_k127_39806_7 TIGRFAM Tyrosine recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009333 271.0
TLS2_k127_39806_8 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000000000000000008958 268.0
TLS2_k127_39806_9 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.0000000000000000000000000000000000000000000000000000000000000000000002397 263.0
TLS2_k127_3980990_0 Esterase of the alpha-beta hydrolase superfamily - - - 0.00000000000000000000000000000001716 147.0
TLS2_k127_3991403_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 496.0
TLS2_k127_3991403_1 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005407 374.0
TLS2_k127_3991403_2 Thymidine kinase K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.000000000000000000000000000000000000000000000000000000000000000000002182 240.0
TLS2_k127_3991403_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000004878 214.0
TLS2_k127_3991403_4 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000001024 216.0
TLS2_k127_3991403_5 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000002779 196.0
TLS2_k127_3991403_6 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000001575 190.0
TLS2_k127_3991403_7 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000003383 177.0
TLS2_k127_3991403_8 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000000005259 111.0
TLS2_k127_3991403_9 Belongs to the peptidase S1C family K04691,K04771,K04772 - 3.4.21.107 0.00000000002952 74.0
TLS2_k127_3997917_0 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004436 436.0
TLS2_k127_3997917_1 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 422.0
TLS2_k127_3997917_2 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 389.0
TLS2_k127_3997917_3 protein methyltransferase activity K00568,K02687 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 298.0
TLS2_k127_3997917_4 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000000000000000000000000000000000000000000003604 220.0
TLS2_k127_3997917_5 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000002991 194.0
TLS2_k127_3997917_6 Polysaccharide biosynthesis/export protein K01991 - - 0.000000000000000000000000000000006234 144.0
TLS2_k127_3997917_7 Histidine kinase - - - 0.00000000008065 72.0
TLS2_k127_4015972_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 614.0
TLS2_k127_4015972_1 Belongs to the glycosyl hydrolase 18 family K01183 - 3.2.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 376.0
TLS2_k127_4015972_2 nuclease activity - - - 0.00000000000000000000000000001359 121.0
TLS2_k127_4015972_3 PFAM Transposase IS200 like - - - 0.0000000000000000000000000004138 122.0
TLS2_k127_4015972_4 Histone methylation protein DOT1 - - - 0.000000001872 62.0
TLS2_k127_403024_0 Histidine kinase - - - 4.574e-289 919.0
TLS2_k127_403024_1 catalase activity K07217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 418.0
TLS2_k127_403024_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008894 402.0
TLS2_k127_403024_3 PFAM MCP methyltransferase CheR-type K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 335.0
TLS2_k127_403024_4 Response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 313.0
TLS2_k127_403024_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001676 292.0
TLS2_k127_403024_6 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000278 181.0
TLS2_k127_403024_7 histidine kinase A domain protein - - - 0.00000000000000000000000000000000001788 139.0
TLS2_k127_4031393_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 608.0
TLS2_k127_4031393_1 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000001161 204.0
TLS2_k127_4034313_0 DEAD DEAH box helicase K03724 - - 0.0 1517.0
TLS2_k127_4034313_1 Belongs to the arylamine N-acetyltransferase family K00675 - 2.3.1.118 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003855 280.0
TLS2_k127_4034313_2 - - - - 0.00000000000000000000000000000000000000001033 163.0
TLS2_k127_4034313_3 - - - - 0.000000000000000000000000003972 118.0
TLS2_k127_4034313_4 nitronate monooxygenase activity K00459 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.13.12.16 0.000000000000000000000000004219 115.0
TLS2_k127_4039788_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 337.0
TLS2_k127_4039788_1 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 304.0
TLS2_k127_4039788_2 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000008735 102.0
TLS2_k127_4039788_3 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0000543 48.0
TLS2_k127_4039788_4 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0001769 49.0
TLS2_k127_4039788_5 Sulfate permease family K03321 - - 0.000703 42.0
TLS2_k127_4075682_0 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 598.0
TLS2_k127_4075682_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 565.0
TLS2_k127_4075682_10 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000004479 160.0
TLS2_k127_4075682_11 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000008001 145.0
TLS2_k127_4075682_12 bacterial (prokaryotic) histone like domain K03530 - - 0.00000000000000000000000000000000292 130.0
TLS2_k127_4075682_13 Regulatory protein - - - 0.00000000000000003541 87.0
TLS2_k127_4075682_2 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 567.0
TLS2_k127_4075682_3 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007339 529.0
TLS2_k127_4075682_4 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 382.0
TLS2_k127_4075682_5 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 359.0
TLS2_k127_4075682_6 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000002354 263.0
TLS2_k127_4075682_7 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001933 263.0
TLS2_k127_4075682_8 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000003518 245.0
TLS2_k127_4075682_9 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000002083 198.0
TLS2_k127_4081885_0 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007789 496.0
TLS2_k127_4081885_1 TIGRFAM carbamoyl-phosphate synthase, small subunit K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 439.0
TLS2_k127_4081885_10 Ribosomal protein L11 methyltransferase K02687 - - 0.000000000000000000000000000000001504 142.0
TLS2_k127_4081885_11 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000003432 141.0
TLS2_k127_4081885_12 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000005022 87.0
TLS2_k127_4081885_13 PFAM PEGA domain - - - 0.0000000003892 72.0
TLS2_k127_4081885_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 394.0
TLS2_k127_4081885_3 ABC transporter, ATP-binding protein K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 307.0
TLS2_k127_4081885_4 Bacillithiol biosynthesis BshC K22136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000743 310.0
TLS2_k127_4081885_5 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000148 304.0
TLS2_k127_4081885_6 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000002222 233.0
TLS2_k127_4081885_7 XdhC and CoxI family K07402 - - 0.000000000000000000000000000000000000000000000000000000001528 213.0
TLS2_k127_4081885_8 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000005899 157.0
TLS2_k127_4081885_9 translation initiation factor activity K06996 - - 0.000000000000000000000000000000000000001418 151.0
TLS2_k127_4111707_0 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 436.0
TLS2_k127_4111707_1 Inosine-uridine preferring nucleoside hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006119 287.0
TLS2_k127_4113085_0 PFAM ABC transporter - - - 0.0000000000000000000000008191 104.0
TLS2_k127_4113085_1 Multicopper oxidase - - - 0.0000001203 65.0
TLS2_k127_4139195_0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 310.0
TLS2_k127_4139195_1 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000001716 155.0
TLS2_k127_4139195_2 - - - - 0.00000000000000000000000007999 122.0
TLS2_k127_4142437_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 380.0
TLS2_k127_4142437_1 Methyltransferase type 12 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 309.0
TLS2_k127_4142437_2 Prolyl oligopeptidase - - - 0.000000001133 64.0
TLS2_k127_4163155_0 short chain dehydrogenase K07124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005235 259.0
TLS2_k127_4163155_1 NUDIX domain - - - 0.000000000000000000000000000000000000000001483 160.0
TLS2_k127_4163155_2 Catalyzes the sodium-dependent transport of glutamate K03312 - - 0.00000000000000000002116 93.0
TLS2_k127_4165128_0 Elongation factor G, domain IV K02355 - - 4.06e-250 790.0
TLS2_k127_4165128_1 PFAM Type II secretion system protein E K02454,K02504,K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 592.0
TLS2_k127_4165128_10 Putative cyclase - - - 0.00001406 58.0
TLS2_k127_4165128_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007468 310.0
TLS2_k127_4165128_3 beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001818 287.0
TLS2_k127_4165128_4 COGs COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007998 283.0
TLS2_k127_4165128_5 Biotin-lipoyl like K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003544 272.0
TLS2_k127_4165128_6 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000003523 223.0
TLS2_k127_4165128_7 PFAM Type II secretion system protein E K02454,K02504,K02652 - - 0.00000000000000000000000000000000000000000000000000003835 193.0
TLS2_k127_4165128_8 - - - - 0.000000000000000000000000000000000000000000000002928 178.0
TLS2_k127_4165128_9 Protein of unknown function DUF86 - - - 0.00000002146 64.0
TLS2_k127_4179864_0 Domain of unknown function (DUF4040) K05559,K05565 - - 7.56e-248 800.0
TLS2_k127_4179864_1 Protein of unknown function, DUF255 K06888 - - 1.719e-212 681.0
TLS2_k127_4179864_10 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 364.0
TLS2_k127_4179864_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000086 347.0
TLS2_k127_4179864_12 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 323.0
TLS2_k127_4179864_13 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 322.0
TLS2_k127_4179864_14 Belongs to the MlaE permease family K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001513 247.0
TLS2_k127_4179864_15 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000003255 229.0
TLS2_k127_4179864_16 AAA domain, putative AbiEii toxin, Type IV TA system K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000009576 239.0
TLS2_k127_4179864_17 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000502 232.0
TLS2_k127_4179864_18 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000000000000000000000000000000000000000000000000001105 216.0
TLS2_k127_4179864_19 intracellular protease K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000002721 174.0
TLS2_k127_4179864_2 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000621 586.0
TLS2_k127_4179864_20 - - - - 0.0000000000000000000000000000000000009113 152.0
TLS2_k127_4179864_21 methyltransferase - - - 0.00000000000000000000000000000000008112 146.0
TLS2_k127_4179864_22 AMP binding - - - 0.0000000000000000000000000000000001264 139.0
TLS2_k127_4179864_23 Glycosyltransferase Family 4 K14335 - - 0.00000000000000000000000000001701 137.0
TLS2_k127_4179864_24 CHRD domain - - - 0.00000000000000000000000000004224 124.0
TLS2_k127_4179864_25 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05560,K05567 - - 0.0000000000000000000000000007939 117.0
TLS2_k127_4179864_26 PFAM Ribonuclease BN-like family K07058 - - 0.0000000000000000000000001013 119.0
TLS2_k127_4179864_27 WD40-like Beta Propeller - - - 0.000000000000000000000004214 118.0
TLS2_k127_4179864_28 monovalent cation:proton antiporter activity K05571 - - 0.000000000000000000466 96.0
TLS2_k127_4179864_29 multisubunit Na H antiporter MnhE subunit K05569 - - 0.0000000000000005624 92.0
TLS2_k127_4179864_3 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01740 - 2.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008204 584.0
TLS2_k127_4179864_30 COGs COG0589 Universal stress protein UspA and related nucleotide-binding protein - - - 0.000000000002136 80.0
TLS2_k127_4179864_31 general stress protein - - - 0.000003041 56.0
TLS2_k127_4179864_32 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.00007838 54.0
TLS2_k127_4179864_4 Proton-conducting membrane transporter K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 516.0
TLS2_k127_4179864_5 peptidase activity, acting on L-amino acid peptides K07004,K09955 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006543 422.0
TLS2_k127_4179864_6 2-epimerase K16213 - 5.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 416.0
TLS2_k127_4179864_7 ROK family K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 414.0
TLS2_k127_4179864_8 response regulator K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003003 395.0
TLS2_k127_4179864_9 Glycosyl hydrolases family 16 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006558 355.0
TLS2_k127_4182458_0 Glycosyl hydrolase family 10 K01181 - 3.2.1.8 7.228e-237 756.0
TLS2_k127_4182458_1 - - - - 0.00000000000000000000000004797 113.0
TLS2_k127_4182458_2 CAAX protease self-immunity K07052 - - 0.00000000000004936 83.0
TLS2_k127_4212810_0 PFAM sodium calcium exchanger membrane region K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007941 301.0
TLS2_k127_4212810_1 Large family of predicted nucleotide-binding domains - - - 0.00000000000000000000000252 109.0
TLS2_k127_4212810_2 Peptidase M66 - - - 0.000000000004424 79.0
TLS2_k127_4212810_3 positive regulation of growth - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.00000000001004 67.0
TLS2_k127_4212810_4 - - - - 0.000000006529 63.0
TLS2_k127_4216229_0 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007012 468.0
TLS2_k127_4216229_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000468 288.0
TLS2_k127_4328685_0 D-arabinono-1,4-lactone oxidase K00594 - 1.1.3.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 574.0
TLS2_k127_4328685_1 Tetratricopeptide repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007015 351.0
TLS2_k127_4328685_2 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003543 282.0
TLS2_k127_4328685_3 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000005331 140.0
TLS2_k127_4328685_4 WD40-like Beta Propeller Repeat - GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000001891 103.0
TLS2_k127_4333959_0 Phage tail sheath C-terminal domain K06907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 381.0
TLS2_k127_4333959_1 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 375.0
TLS2_k127_4333959_10 Lanthionine synthetase C family protein - - - 0.0000000000000000000000000000000000004885 154.0
TLS2_k127_4333959_11 Dioxygenase K00449 - 1.13.11.3 0.0000000000000000003214 96.0
TLS2_k127_4333959_12 - - - - 0.0000000000000002315 92.0
TLS2_k127_4333959_13 heme oxygenase (decyclizing) activity K07145,K21481 - 1.14.99.48,1.14.99.57 0.00000000000008495 85.0
TLS2_k127_4333959_2 D-alanyl-D-alanine carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005036 320.0
TLS2_k127_4333959_3 Putative neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 312.0
TLS2_k127_4333959_4 ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001878 272.0
TLS2_k127_4333959_6 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000001979 192.0
TLS2_k127_4333959_7 Cobalamin B12-binding domain protein - - - 0.0000000000000000000000000000000000000000000006705 181.0
TLS2_k127_4333959_8 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000004234 171.0
TLS2_k127_4333959_9 Lanthionine synthetase C family protein - - - 0.00000000000000000000000000000000000004528 163.0
TLS2_k127_4334239_0 Methionine synthase K00548 - 2.1.1.13 2.7e-322 998.0
TLS2_k127_4348193_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 539.0
TLS2_k127_4348193_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002825 304.0
TLS2_k127_4348193_2 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006194 311.0
TLS2_k127_4348193_3 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 303.0
TLS2_k127_4348193_4 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000007303 164.0
TLS2_k127_4348193_5 riboflavin synthase, alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.00000000000000000000000000000000000004836 152.0
TLS2_k127_4348193_6 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000437 117.0
TLS2_k127_43708_0 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000001224 188.0
TLS2_k127_43708_1 Uncharacterized conserved protein (DUF2203) - - - 0.0000000000000000000000001023 112.0
TLS2_k127_43708_2 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000003669 105.0
TLS2_k127_43739_0 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000005944 189.0
TLS2_k127_43739_1 Uncharacterized conserved protein (DUF2203) - - - 0.000000000000000000000002473 108.0
TLS2_k127_43739_2 Methyltransferase domain - - - 0.0000000000000000000009242 104.0
TLS2_k127_4409514_0 PA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 314.0
TLS2_k127_4409514_1 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000002679 224.0
TLS2_k127_4409514_2 RNA polymerase sigma factor K03088 - - 0.00000000000000000000000000003938 124.0
TLS2_k127_4409514_3 catalytic domain of components of various dehydrogenase complexes K00658 - 2.3.1.61 0.00000000005319 63.0
TLS2_k127_4446271_0 Domain of unknown function (DUF1998) K06877 - - 5.158e-289 908.0
TLS2_k127_4446271_1 PFAM UDP-galactopyranose mutase, C-terminal K01854 - 5.4.99.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005956 621.0
TLS2_k127_4446271_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 343.0
TLS2_k127_4446271_11 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 314.0
TLS2_k127_4446271_12 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001363 281.0
TLS2_k127_4446271_13 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000000001609 239.0
TLS2_k127_4446271_14 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000008329 199.0
TLS2_k127_4446271_15 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000001579 195.0
TLS2_k127_4446271_16 Exonuclease K07502 - - 0.0000000000000000000000000000000000000000000000000002804 213.0
TLS2_k127_4446271_17 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000001457 187.0
TLS2_k127_4446271_18 Binds the 23S rRNA K02909 - - 0.0000000000000000000000005607 106.0
TLS2_k127_4446271_19 Tellurite resistance protein TerB K05801 - - 0.00009831 53.0
TLS2_k127_4446271_2 Sodium:alanine symporter family K03310 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 552.0
TLS2_k127_4446271_3 galactose-1-phosphate uridylyltransferase K00965 GO:0003674,GO:0003824,GO:0004335,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006012,GO:0006793,GO:0006796,GO:0008108,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019200,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0046872,GO:0046914,GO:0070569,GO:0071704,GO:1901575 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007777 497.0
TLS2_k127_4446271_4 6-phospho-beta-galactosidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 504.0
TLS2_k127_4446271_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 521.0
TLS2_k127_4446271_6 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004492 490.0
TLS2_k127_4446271_7 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 455.0
TLS2_k127_4446271_8 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004437 461.0
TLS2_k127_4446271_9 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 399.0
TLS2_k127_4465601_0 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000002389 196.0
TLS2_k127_4465601_1 - - - - 0.0000000000000000000000003699 113.0
TLS2_k127_4465601_2 DNA-templated transcription, initiation K03088 - - 0.000002601 59.0
TLS2_k127_4481165_0 4Fe-4S dicluster domain K00184 - - 1.345e-317 1009.0
TLS2_k127_4481165_1 Glycosyl hydrolase family 10 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 566.0
TLS2_k127_4481165_2 Cytochrome c7 and related cytochrome c K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001254 276.0
TLS2_k127_4481165_3 Cytochrome c - - - 0.000000000000000000000000000000000000000000000002862 183.0
TLS2_k127_4481165_4 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000003332 160.0
TLS2_k127_4481165_6 - - - - 0.0000002883 58.0
TLS2_k127_4481165_7 - - - - 0.000005903 57.0
TLS2_k127_4501788_0 HypF finger K04656 - - 1.13e-288 905.0
TLS2_k127_4501788_1 Belongs to the type-B carboxylesterase lipase family K03929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000394 520.0
TLS2_k127_4501788_2 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007251 353.0
TLS2_k127_4501788_3 COG0725 ABC-type molybdate transport system, periplasmic component K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 297.0
TLS2_k127_4501788_4 Binding-protein-dependent transport system inner membrane component K02018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007262 277.0
TLS2_k127_4501788_5 Uncharacterized ACR, COG1678 - - - 0.000000000000000000000000000000000004376 146.0
TLS2_k127_4519182_0 PFAM glycoside hydrolase family 3 domain protein K05349 - 3.2.1.21 0.0 1118.0
TLS2_k127_4519182_1 Belongs to the UPF0061 (SELO) family K08997 - - 3.432e-198 625.0
TLS2_k127_4519182_2 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 317.0
TLS2_k127_4519182_3 DNA-templated transcription, initiation K02405 - - 0.000000000000000000000000000000000000000000000008966 182.0
TLS2_k127_4519182_4 PLD-like domain - - - 0.00001453 57.0
TLS2_k127_4519182_5 cellulase activity - - - 0.00002538 57.0
TLS2_k127_4519383_0 MacB-like periplasmic core domain - - - 1.81e-285 903.0
TLS2_k127_4519383_1 peptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 575.0
TLS2_k127_4519383_2 transcriptional regulator PadR family - - - 0.000000000000000000000000000000000000000000000000008341 182.0
TLS2_k127_4519383_4 thiolester hydrolase activity - - - 0.0000000001388 64.0
TLS2_k127_4519383_5 Alpha/beta hydrolase family - - - 0.0004499 51.0
TLS2_k127_452046_0 oxidoreductase activity - - - 0.00000000000000001764 96.0
TLS2_k127_452046_1 oxidoreductase activity - - - 0.000000001345 71.0
TLS2_k127_4523502_0 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006282 551.0
TLS2_k127_4523502_1 transmembrane spans. The family include ribonuclease BN that is involved in tRNA maturation P32146. This family of proteins does not seem to contain any completely conserved polar residues that would be expected in a nuclease enzyme, suggesting that many members of this family may not have this catalytic activity K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007617 289.0
TLS2_k127_4547514_0 WD40-like Beta Propeller Repeat - - - 7.574e-228 741.0
TLS2_k127_4547514_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 459.0
TLS2_k127_4547514_2 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 358.0
TLS2_k127_4547514_3 Thioesterase-like superfamily K01075 - 3.1.2.23 0.000000000000000000000000000000008845 137.0
TLS2_k127_4547514_4 DinB superfamily - - - 0.0000000000000000000000007543 115.0
TLS2_k127_4547514_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000001217 109.0
TLS2_k127_4547514_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000001477 107.0
TLS2_k127_461401_0 WD40-like Beta Propeller Repeat - - - 9.577e-278 863.0
TLS2_k127_4639394_0 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1026.0
TLS2_k127_4639394_1 4Fe-4S ferredoxin iron-sulfur binding domain protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 355.0
TLS2_k127_4639394_2 C4-dicarboxylate anaerobic carrier - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006282 359.0
TLS2_k127_4639394_3 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000003202 274.0
TLS2_k127_4639394_4 oxidoreductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000008741 227.0
TLS2_k127_4639394_5 phosphoprotein phosphatase activity K14680 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000006561 199.0
TLS2_k127_4639394_6 - K00241 - - 0.00000000000000000000000000000000000000000000002767 177.0
TLS2_k127_4639394_7 von Willebrand factor, type A - - - 0.0000000000000000000000000000003796 134.0
TLS2_k127_4639394_8 Aminotransferase class-V - - - 0.000000000000008248 75.0
TLS2_k127_4652967_0 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000005752 244.0
TLS2_k127_466918_0 aconitate hydratase K01681 - 4.2.1.3 0.0 1135.0
TLS2_k127_466918_1 GTP-binding protein TypA K06207 - - 2.211e-269 848.0
TLS2_k127_466918_10 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 422.0
TLS2_k127_466918_11 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003711 420.0
TLS2_k127_466918_12 PFAM sodium calcium exchanger K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 389.0
TLS2_k127_466918_13 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 392.0
TLS2_k127_466918_14 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 349.0
TLS2_k127_466918_15 PFAM Peptidase M16 inactive domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 345.0
TLS2_k127_466918_16 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007074 331.0
TLS2_k127_466918_17 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000408 317.0
TLS2_k127_466918_18 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 308.0
TLS2_k127_466918_19 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001352 296.0
TLS2_k127_466918_2 Peptidase family M49 - - - 6.047e-231 727.0
TLS2_k127_466918_20 PFAM peptidase M16 domain protein K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007067 296.0
TLS2_k127_466918_21 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002048 274.0
TLS2_k127_466918_22 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000004639 280.0
TLS2_k127_466918_23 FCD K05799 - - 0.00000000000000000000000000000000000000000000000000000000000008566 221.0
TLS2_k127_466918_24 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000002164 210.0
TLS2_k127_466918_25 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000002654 198.0
TLS2_k127_466918_26 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000007667 169.0
TLS2_k127_466918_27 Transcriptional regulator - - - 0.000000000000000000000000000000000000002901 159.0
TLS2_k127_466918_28 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000000002972 145.0
TLS2_k127_466918_29 Protein of unknown function (DUF3810) - - - 0.00000000000000000000000000000735 133.0
TLS2_k127_466918_3 PFAM Peptidase M16 inactive domain K07263 - - 7.52e-200 656.0
TLS2_k127_466918_30 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000006279 121.0
TLS2_k127_466918_31 Putative regulatory protein - - - 0.000000000000000002443 87.0
TLS2_k127_466918_32 - - - - 0.00000000000008104 78.0
TLS2_k127_466918_33 Glu-tRNAGln amidotransferase C subunit K02435 - 6.3.5.6,6.3.5.7 0.00000000000009449 76.0
TLS2_k127_466918_34 - - - - 0.000000003924 65.0
TLS2_k127_466918_35 Matrixin - - - 0.00000001378 68.0
TLS2_k127_466918_36 Mitochondrial K+-H+ exchange-related - - - 0.0001549 52.0
TLS2_k127_466918_4 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 552.0
TLS2_k127_466918_5 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 541.0
TLS2_k127_466918_6 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 527.0
TLS2_k127_466918_7 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 466.0
TLS2_k127_466918_8 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007258 474.0
TLS2_k127_466918_9 homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 431.0
TLS2_k127_4678963_0 PFAM Bile acid sodium symporter K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000732 580.0
TLS2_k127_4678963_1 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 382.0
TLS2_k127_4678963_2 - - - - 0.00000000000000000000000000000000000000000000000002383 191.0
TLS2_k127_4678963_3 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000000001433 122.0
TLS2_k127_4678963_4 bis(5'-adenosyl)-triphosphatase activity K02503 - - 0.0002938 48.0
TLS2_k127_4681490_0 PFAM von Willebrand factor type A - - - 0.0000000000000000000000000000000633 138.0
TLS2_k127_4681490_1 ZIP Zinc transporter K16267 - - 0.0007427 42.0
TLS2_k127_4684849_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1116.0
TLS2_k127_4684849_1 Belongs to the IlvD Edd family K01687,K22186 - 4.2.1.82,4.2.1.9 9.43e-266 832.0
TLS2_k127_4684849_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006607 313.0
TLS2_k127_4684849_3 Short-chain dehydrogenase reductase SDR K00065 - 1.1.1.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002909 284.0
TLS2_k127_4684849_4 - - - - 0.0000000008186 71.0
TLS2_k127_4688597_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1266.0
TLS2_k127_4688597_1 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 604.0
TLS2_k127_4688597_10 Domain of unknown function (DUF4154) - - - 0.00000000000000000000000000000000412 138.0
TLS2_k127_4688597_11 bacterial OsmY and nodulation domain K04065 - - 0.000000000008029 76.0
TLS2_k127_4688597_2 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 473.0
TLS2_k127_4688597_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 426.0
TLS2_k127_4688597_4 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 394.0
TLS2_k127_4688597_5 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 336.0
TLS2_k127_4688597_6 photoreceptor activity K11354 GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007602,GO:0008150,GO:0008152,GO:0009314,GO:0009416,GO:0009581,GO:0009582,GO:0009583,GO:0009585,GO:0009605,GO:0009628,GO:0009639,GO:0009881,GO:0009883,GO:0009987,GO:0010017,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0018298,GO:0019538,GO:0023052,GO:0036211,GO:0038023,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051606,GO:0051716,GO:0060089,GO:0065007,GO:0071214,GO:0071478,GO:0071482,GO:0071489,GO:0071704,GO:0104004,GO:0140096,GO:1901564 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 301.0
TLS2_k127_4688597_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002188 286.0
TLS2_k127_4688597_8 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000000001387 197.0
TLS2_k127_4688597_9 response regulator receiver - - - 0.0000000000000000000000000000000000000000001179 165.0
TLS2_k127_4691090_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 0.0 1342.0
TLS2_k127_4691090_1 nitrite transmembrane transporter activity - - - 2.154e-261 826.0
TLS2_k127_4691090_10 Transcriptional regulator, Crp Fnr family K21564 - - 0.000000000000000000000000000000000000000000000002802 183.0
TLS2_k127_4691090_11 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000003218 175.0
TLS2_k127_4691090_12 Cupin domain - - - 0.0000000000000000000002022 102.0
TLS2_k127_4691090_13 - - - - 0.00000000000000000006474 93.0
TLS2_k127_4691090_14 electron transport protein SCO1 SenC K07152 - - 0.000000000000611 83.0
TLS2_k127_4691090_15 - - - - 0.0000002014 63.0
TLS2_k127_4691090_16 Thiopurine S-methyltransferase (TPMT) - - - 0.0000008387 59.0
TLS2_k127_4691090_17 COG COG5492 Bacterial surface proteins containing Ig-like domains - - - 0.00009042 53.0
TLS2_k127_4691090_2 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 1.976e-235 736.0
TLS2_k127_4691090_3 heme-copper terminal oxidase activity K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 581.0
TLS2_k127_4691090_4 nitrite reductase K00368 - 1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 455.0
TLS2_k127_4691090_5 4 iron, 4 sulfur cluster binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 355.0
TLS2_k127_4691090_6 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 366.0
TLS2_k127_4691090_7 oxidoreductase activity, acting on diphenols and related substances as donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000126 249.0
TLS2_k127_4691090_8 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000001979 240.0
TLS2_k127_4691090_9 Di-iron-containing protein involved in the repair of iron-sulfur clusters K07322 - - 0.00000000000000000000000000000000000000000000000000000000003197 214.0
TLS2_k127_4698239_0 Peptidase family M3 K01392 - 3.4.24.15 3.486e-207 663.0
TLS2_k127_4698239_1 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 537.0
TLS2_k127_4698239_10 - - - - 0.0000000000000000869 93.0
TLS2_k127_4698239_11 - - - - 0.00000000002376 66.0
TLS2_k127_4698239_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 373.0
TLS2_k127_4698239_3 D-xylose transmembrane transport K10543 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 348.0
TLS2_k127_4698239_4 beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 314.0
TLS2_k127_4698239_5 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 306.0
TLS2_k127_4698239_6 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001636 273.0
TLS2_k127_4698239_7 Phospholipase/Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001118 254.0
TLS2_k127_4698239_8 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000002517 222.0
TLS2_k127_4698239_9 PFAM SNARE associated Golgi protein - - - 0.000000000000000000004985 101.0
TLS2_k127_4700558_0 ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002813 391.0
TLS2_k127_4700558_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009796 281.0
TLS2_k127_4700558_2 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.000000000000000000000000000485 118.0
TLS2_k127_4700558_3 General stress protein K06884 - - 0.0000000000004617 76.0
TLS2_k127_4703613_0 LUD domain K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 467.0
TLS2_k127_4703613_1 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007663 290.0
TLS2_k127_4703613_2 Fe-S oxidoreductase K18928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003718 261.0
TLS2_k127_4703613_3 LUD domain K00782 - - 0.00000000000000000000000001594 127.0
TLS2_k127_4712868_0 PFAM Radical SAM - - - 1.828e-222 700.0
TLS2_k127_4712868_1 alpha-L-arabinofuranosidase K01209 - 3.2.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 608.0
TLS2_k127_4712868_2 chorismate binding enzyme K01665,K02619,K03342,K13503,K13950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.85,4.1.3.27,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 559.0
TLS2_k127_4712868_3 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01534 - 3.6.3.3,3.6.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 526.0
TLS2_k127_4712868_4 3-demethylubiquinone-9 3-methyltransferase K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000901 208.0
TLS2_k127_4712868_5 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000002158 146.0
TLS2_k127_4714948_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1128.0
TLS2_k127_4718594_0 PFAM PBS lyase HEAT domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004051 610.0
TLS2_k127_4718594_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 353.0
TLS2_k127_4718916_0 Glycosyl hydrolase, family 20, catalytic domain - - - 2.869e-280 887.0
TLS2_k127_4718916_1 protein conserved in bacteria K09955 - - 1.65e-245 771.0
TLS2_k127_4718916_2 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 310.0
TLS2_k127_4718916_3 Nodulation protein S (NodS) - - - 0.000000000000000000000000000000000000000000000000000000000000000000004281 239.0
TLS2_k127_4718916_4 PFAM Rhodanese domain protein K03892 - - 0.00000000000000000000000000000000000000000000000000000000000000000007677 239.0
TLS2_k127_4718916_5 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000001153 152.0
TLS2_k127_4718916_6 GIY-YIG catalytic domain - - - 0.0000000000000007306 80.0
TLS2_k127_4718916_7 COG0463 Glycosyltransferases involved in cell wall biogenesis K16698 - - 0.000000000000002607 86.0
TLS2_k127_4718916_8 DinB family - - - 0.00000000000001822 79.0
TLS2_k127_4718916_9 - - - - 0.00000000000009751 79.0
TLS2_k127_4727171_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.488e-269 847.0
TLS2_k127_4727360_0 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004803 295.0
TLS2_k127_4727360_1 Berberine and berberine like - - - 0.000000000000000000000000000000000000000000000001617 180.0
TLS2_k127_4727703_0 Carboxypeptidase regulatory-like domain - - - 6.967e-258 838.0
TLS2_k127_4727703_1 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 - 3.4.21.83 4.438e-216 709.0
TLS2_k127_4727703_10 DoxX - - - 0.0000000000000000000000000000000000001301 147.0
TLS2_k127_4727703_11 TonB-dependent Receptor Plug Domain - - - 0.0000000000000001152 85.0
TLS2_k127_4727703_13 PhoPQ-activated pathogenicity-related protein - - - 0.0001268 44.0
TLS2_k127_4727703_2 His Kinase A (phosphoacceptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000619 566.0
TLS2_k127_4727703_3 neurotransmitter:sodium symporter activity K03308,K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 456.0
TLS2_k127_4727703_4 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 437.0
TLS2_k127_4727703_5 Histidine Phosphotransfer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 392.0
TLS2_k127_4727703_6 Protein of unknown function (DUF1593) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 303.0
TLS2_k127_4727703_7 PFAM Formylglycine-generating sulfatase enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000079 236.0
TLS2_k127_4727703_8 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000002915 198.0
TLS2_k127_4727703_9 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000002536 177.0
TLS2_k127_474294_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008763 607.0
TLS2_k127_474294_1 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 375.0
TLS2_k127_474294_10 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000002576 157.0
TLS2_k127_474294_11 Regulates arginine biosynthesis genes K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000007711 113.0
TLS2_k127_474294_12 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.000000000000000000008639 101.0
TLS2_k127_474294_13 - - - - 0.00000003614 64.0
TLS2_k127_474294_14 BON domain - - - 0.0000007642 61.0
TLS2_k127_474294_15 DNA-sulfur modification-associated - - - 0.0001139 54.0
TLS2_k127_474294_2 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008897 347.0
TLS2_k127_474294_3 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007168 348.0
TLS2_k127_474294_4 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005106 303.0
TLS2_k127_474294_5 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007989 301.0
TLS2_k127_474294_6 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000001689 265.0
TLS2_k127_474294_7 Belongs to the UPF0271 (lamB) family K07160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002244 250.0
TLS2_k127_474294_8 Predicted membrane protein (DUF2339) - - - 0.0000000000000000000000000000000000000000152 175.0
TLS2_k127_474294_9 Arginosuccinate synthase K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.0000000000000000000000000000000000005708 158.0
TLS2_k127_4747483_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 8.466e-300 944.0
TLS2_k127_4747483_1 CarboxypepD_reg-like domain - - - 4.26e-269 872.0
TLS2_k127_4747483_10 Met-10+ like-protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000021 248.0
TLS2_k127_4747483_11 Cytochrome c oxidase subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000004359 250.0
TLS2_k127_4747483_12 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000000001795 210.0
TLS2_k127_4747483_13 PFAM Cytochrome C K00406 - - 0.000000000000000000000000000000000000000001982 162.0
TLS2_k127_4747483_14 Domain of unknown function (DUF4397) - - - 0.00000000000000000000000000000000009446 145.0
TLS2_k127_4747483_15 - - - - 0.00000000000000000002565 104.0
TLS2_k127_4747483_16 protein conserved in bacteria K15539 - - 0.0000000000424 73.0
TLS2_k127_4747483_17 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000032 66.0
TLS2_k127_4747483_18 ABC transporter substrate-binding protein - - - 0.00000462 59.0
TLS2_k127_4747483_19 Putative zinc-finger - - - 0.000164 49.0
TLS2_k127_4747483_2 CarboxypepD_reg-like domain - - - 3.804e-260 848.0
TLS2_k127_4747483_3 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298,K15408 - 1.10.3.10,1.9.3.1 5.56e-258 818.0
TLS2_k127_4747483_4 ASPIC and UnbV - - - 6.837e-252 788.0
TLS2_k127_4747483_5 Carbon starvation protein K06200 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 516.0
TLS2_k127_4747483_6 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 400.0
TLS2_k127_4747483_7 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K17223 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007021 334.0
TLS2_k127_4747483_8 tRNA synthetases class I (E and Q), catalytic domain K01894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000726 308.0
TLS2_k127_4747483_9 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000002662 289.0
TLS2_k127_4751969_0 belongs to the thioredoxin family K03671,K05838 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 416.0
TLS2_k127_4751969_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 332.0
TLS2_k127_4751969_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001177 246.0
TLS2_k127_4756245_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.261e-313 974.0
TLS2_k127_4756245_1 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 6.035e-200 630.0
TLS2_k127_4756245_10 ubiE/COQ5 methyltransferase family - - - 0.000004417 56.0
TLS2_k127_4756245_11 - - - - 0.00001663 51.0
TLS2_k127_4756245_2 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008504 610.0
TLS2_k127_4756245_3 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 358.0
TLS2_k127_4756245_4 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 316.0
TLS2_k127_4756245_5 Belongs to the ABC transporter superfamily K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 317.0
TLS2_k127_4756245_6 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000000000000543 177.0
TLS2_k127_4756245_7 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.000000000000000000001151 94.0
TLS2_k127_4756245_8 - - - - 0.000000000000001573 87.0
TLS2_k127_4756245_9 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000000283 78.0
TLS2_k127_4757378_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 8.711e-232 742.0
TLS2_k127_4757378_1 COG0405 Gamma-glutamyltransferase K00681 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 602.0
TLS2_k127_4757378_10 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 299.0
TLS2_k127_4757378_11 PFAM glycosyl transferase group 1 K12995,K13668 - 2.4.1.346,2.4.1.348 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002614 298.0
TLS2_k127_4757378_12 glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007459 295.0
TLS2_k127_4757378_13 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004613 276.0
TLS2_k127_4757378_14 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002634 277.0
TLS2_k127_4757378_15 aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005708 279.0
TLS2_k127_4757378_16 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000002385 265.0
TLS2_k127_4757378_17 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000004037 244.0
TLS2_k127_4757378_18 Cytochrome C biogenesis protein transmembrane region K06196,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000001046 241.0
TLS2_k127_4757378_19 spore germination - - - 0.0000000000000000000000000000000000000000000000000000000000003182 230.0
TLS2_k127_4757378_2 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 597.0
TLS2_k127_4757378_20 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000005513 222.0
TLS2_k127_4757378_21 Nucleic acid binding K03698 - - 0.0000000000000000000000000000000000000000000000000000000001489 219.0
TLS2_k127_4757378_22 Uncharacterised nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000000000000007561 199.0
TLS2_k127_4757378_23 Polysaccharide export protein K01991,K20988 - - 0.0000000000000000000000000000000000000000000000006961 197.0
TLS2_k127_4757378_24 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000003484 186.0
TLS2_k127_4757378_25 geranylgeranyl reductase activity K06444,K17830 - 1.3.1.101,1.3.7.11,5.5.1.18 0.000000000000000000000000000000000000000000001779 181.0
TLS2_k127_4757378_26 (GGDEF) domain - - - 0.0000000000000000000000000000000000000007599 167.0
TLS2_k127_4757378_27 RNA polymerase sigma factor K02405 - - 0.0000000000000000000000000000000000001139 155.0
TLS2_k127_4757378_28 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000004407 140.0
TLS2_k127_4757378_29 O-Antigen ligase K02847 - - 0.0000000000000000000000000000000005829 149.0
TLS2_k127_4757378_3 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003587 539.0
TLS2_k127_4757378_30 Protein of unknown function (DUF456) K09793 - - 0.000000000000000000000000000000003628 133.0
TLS2_k127_4757378_31 Glycosyltransferase Family 4 K02844 - - 0.00000000000000000000000000000000488 146.0
TLS2_k127_4757378_32 Pfam:DUF2029 - - - 0.0000000000000000000000000000003959 139.0
TLS2_k127_4757378_33 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000004022 128.0
TLS2_k127_4757378_34 Asparagine synthase - - - 0.00000000000000000000000002393 126.0
TLS2_k127_4757378_35 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000598 125.0
TLS2_k127_4757378_36 Pfam:DUF2029 - - - 0.00000000000001278 87.0
TLS2_k127_4757378_37 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000000002068 85.0
TLS2_k127_4757378_38 - - - - 0.000000000001548 77.0
TLS2_k127_4757378_39 - - - - 0.000000000002177 68.0
TLS2_k127_4757378_4 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007123 527.0
TLS2_k127_4757378_40 - - - - 0.0000000002552 69.0
TLS2_k127_4757378_41 Putative beta-barrel porin 2 - - - 0.00000002331 66.0
TLS2_k127_4757378_42 HPr kinase - - - 0.000001169 60.0
TLS2_k127_4757378_43 Stress responsive A/B Barrel Domain - - - 0.000001676 54.0
TLS2_k127_4757378_44 PFAM Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000003652 51.0
TLS2_k127_4757378_45 PFAM aminotransferase, class I and II - - - 0.00000886 48.0
TLS2_k127_4757378_46 polysaccharide biosynthetic process - - - 0.00002702 57.0
TLS2_k127_4757378_5 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007755 437.0
TLS2_k127_4757378_6 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007293 417.0
TLS2_k127_4757378_7 ABC-type multidrug transport system ATPase and permease K06147,K06148,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 377.0
TLS2_k127_4757378_8 ATP synthesis coupled electron transport K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007166 350.0
TLS2_k127_4757378_9 histidine kinase A domain protein K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 314.0
TLS2_k127_4758795_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K13015 - 1.1.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 559.0
TLS2_k127_4758795_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000573 475.0
TLS2_k127_4758795_2 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006272 469.0
TLS2_k127_4758795_3 Transglycosylase K05366 GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 474.0
TLS2_k127_4758795_4 pfam psp1 - - - 0.0000000000000000000000000000000000000000000000000000002385 210.0
TLS2_k127_4758795_5 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000003416 196.0
TLS2_k127_4758795_6 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000000003344 187.0
TLS2_k127_4758795_7 DNA polymerase III K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000011 184.0
TLS2_k127_4781867_0 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 365.0
TLS2_k127_4781867_2 Polysaccharide pyruvyl transferase K16710 - - 0.00000000000000000000000000000000000000000000000000005547 210.0
TLS2_k127_4796865_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 616.0
TLS2_k127_4796865_1 - - - - 0.0000000199 61.0
TLS2_k127_4798769_0 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000005521 238.0
TLS2_k127_4798769_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07025 - - 0.0000000000000000000000000000001239 128.0
TLS2_k127_4798769_2 - - - - 0.0000000000001234 73.0
TLS2_k127_4799409_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 3.482e-229 718.0
TLS2_k127_4799409_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 7.777e-215 685.0
TLS2_k127_4799409_10 Putative glucoamylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004134 449.0
TLS2_k127_4799409_11 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008382 435.0
TLS2_k127_4799409_12 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 417.0
TLS2_k127_4799409_13 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005738 406.0
TLS2_k127_4799409_14 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 344.0
TLS2_k127_4799409_15 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008418 333.0
TLS2_k127_4799409_16 Coenzyme A transferase K01029 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008944 327.0
TLS2_k127_4799409_17 SpoIVB peptidase S55 K00973,K02414,K21449 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 336.0
TLS2_k127_4799409_18 3-oxoacid CoA-transferase, a subunit K01027,K01028,K01031,K01034 - 2.8.3.5,2.8.3.6,2.8.3.8,2.8.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 305.0
TLS2_k127_4799409_19 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002044 296.0
TLS2_k127_4799409_2 radical SAM domain protein - - - 5.436e-204 649.0
TLS2_k127_4799409_20 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003497 252.0
TLS2_k127_4799409_21 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000000000000011 250.0
TLS2_k127_4799409_22 response regulator K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001672 273.0
TLS2_k127_4799409_23 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000005566 257.0
TLS2_k127_4799409_24 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000002339 250.0
TLS2_k127_4799409_25 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000006828 246.0
TLS2_k127_4799409_26 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000006314 225.0
TLS2_k127_4799409_27 pfkB family carbohydrate kinase K18478 - 2.7.1.184 0.0000000000000000000000000000000000000000000000000000000000003764 223.0
TLS2_k127_4799409_28 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000005286 222.0
TLS2_k127_4799409_29 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000001716 222.0
TLS2_k127_4799409_3 Ftsk_gamma K03466 - - 6.287e-195 632.0
TLS2_k127_4799409_30 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000021 195.0
TLS2_k127_4799409_31 glycosyl transferase family 39 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000001378 194.0
TLS2_k127_4799409_32 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000001615 181.0
TLS2_k127_4799409_33 HAF family - - - 0.0000000000000000000000000000000000000000000002215 187.0
TLS2_k127_4799409_34 spore germination K07790 - - 0.00000000000000000000000000000000000000001883 165.0
TLS2_k127_4799409_35 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000003374 167.0
TLS2_k127_4799409_36 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000001627 149.0
TLS2_k127_4799409_37 Conserved hypothetical protein 95 - - - 0.000000000000000000000000000000000001082 149.0
TLS2_k127_4799409_38 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000004604 141.0
TLS2_k127_4799409_39 CoA binding domain K06929 - - 0.0000000000000000000000000000000005128 136.0
TLS2_k127_4799409_4 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 1.428e-194 643.0
TLS2_k127_4799409_40 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000000000000000000007551 128.0
TLS2_k127_4799409_41 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000305 121.0
TLS2_k127_4799409_42 Zincin-like metallopeptidase K00930 - 2.7.2.8 0.00000000000000000000001768 116.0
TLS2_k127_4799409_43 Chorismate mutase type II K03856,K04092,K04093,K04516,K13853 - 2.5.1.54,5.4.99.5 0.00000000000000001999 93.0
TLS2_k127_4799409_44 oxidoreductase activity K00337,K03333,K04771,K07114 - 1.1.3.6,1.6.5.3,3.4.21.107 0.00000000000000003164 96.0
TLS2_k127_4799409_45 Tetratricopeptide repeat - - - 0.0000000000002638 82.0
TLS2_k127_4799409_46 Type ii and iii secretion system protein - - - 0.00000000003522 76.0
TLS2_k127_4799409_5 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 552.0
TLS2_k127_4799409_6 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 522.0
TLS2_k127_4799409_7 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008451 518.0
TLS2_k127_4799409_8 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 485.0
TLS2_k127_4799409_9 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005544 481.0
TLS2_k127_4802941_0 DNA replication and repair protein RecF - - - 0.000000000000000000000000692 120.0
TLS2_k127_4802941_1 Psort location Cytoplasmic, score - - - 0.000000000000002812 86.0
TLS2_k127_4802941_2 Domain of unknown function (DUF4194) - - - 0.00000000001711 73.0
TLS2_k127_4821578_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 8.198e-298 941.0
TLS2_k127_4821578_1 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 1.437e-244 783.0
TLS2_k127_4821578_10 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K13639 - - 0.0000000000000000000000000000000000000000000000000000000001077 212.0
TLS2_k127_4821578_11 Spore maturation protein K06373 - - 0.000000000000000000000000000000000000000000000000000000007713 206.0
TLS2_k127_4821578_12 Spore maturation protein K06374 - - 0.00000000000000000000000000000000000000000000000000000001191 204.0
TLS2_k127_4821578_13 HAD-superfamily hydrolase, subfamily IIB K07026 - 3.1.3.70 0.00000000000000000000000000000000000000000004423 183.0
TLS2_k127_4821578_14 Major Facilitator Superfamily - - - 0.000000000000000000004889 97.0
TLS2_k127_4821578_15 - - - - 0.0001273 45.0
TLS2_k127_4821578_2 Belongs to the type-B carboxylesterase lipase family K03929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009966 570.0
TLS2_k127_4821578_3 protein-containing complex disassembly K02837,K07133 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 562.0
TLS2_k127_4821578_4 zinc ion binding K02347,K04477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 545.0
TLS2_k127_4821578_5 Class ii aldolase K01628,K03077 - 4.1.2.17,5.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003481 513.0
TLS2_k127_4821578_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003724 436.0
TLS2_k127_4821578_7 transferase activity, transferring glycosyl groups K13693 - 2.4.1.266 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 368.0
TLS2_k127_4821578_8 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 312.0
TLS2_k127_4821578_9 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 289.0
TLS2_k127_4824728_0 PFAM TonB-dependent Receptor Plug - - - 0.0 1223.0
TLS2_k127_4824728_1 Domain of unknown function (DUF4432) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 587.0
TLS2_k127_4824728_10 calcium- and calmodulin-responsive adenylate cyclase activity K11005,K11029 GO:0001906,GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005576,GO:0006873,GO:0006874,GO:0006875,GO:0007204,GO:0008150,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0019725,GO:0019835,GO:0030003,GO:0031640,GO:0035821,GO:0042592,GO:0044179,GO:0044364,GO:0044419,GO:0044764,GO:0048878,GO:0050801,GO:0051480,GO:0051704,GO:0051715,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0072503,GO:0072507,GO:0098771 4.6.1.1 0.0000000000000000000000000005086 124.0
TLS2_k127_4824728_11 - - - - 0.00000000000000000000001023 115.0
TLS2_k127_4824728_12 DNA-templated transcription, initiation - - - 0.0000000000000000001938 95.0
TLS2_k127_4824728_13 Transcriptional regulatory protein, C terminal - - - 0.00000000000002379 76.0
TLS2_k127_4824728_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005032 509.0
TLS2_k127_4824728_3 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 391.0
TLS2_k127_4824728_4 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007189 396.0
TLS2_k127_4824728_5 Aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 372.0
TLS2_k127_4824728_6 Inosine-uridine preferring nucleoside hydrolase K01250 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 362.0
TLS2_k127_4824728_7 Glycine cleavage system regulatory protein - - - 0.000000000000000000000000000000000000000006669 162.0
TLS2_k127_4824728_8 Histidine kinase K13598 - 2.7.13.3 0.0000000000000000000000000000004063 142.0
TLS2_k127_4824728_9 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000005517 134.0
TLS2_k127_4825973_0 domain, Protein - - - 0.0000000000000001488 93.0
TLS2_k127_4825973_1 PFAM fumarylacetoacetate (FAA) hydrolase K01555 - 3.7.1.2 0.000000000000641 69.0
TLS2_k127_4827669_0 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009106 502.0
TLS2_k127_4827669_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 402.0
TLS2_k127_4827669_2 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 316.0
TLS2_k127_4827669_3 Protein of unknown function (DUF1684) K09164 - - 0.00000000000000000000000000000000001236 148.0
TLS2_k127_4827669_4 Modulates RecA activity K03565 - - 0.0000003857 62.0
TLS2_k127_4827669_5 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0009165 42.0
TLS2_k127_4837030_0 OPT oligopeptide transporter protein - - - 4.628e-201 646.0
TLS2_k127_4837030_1 Dimerisation domain of Zinc Transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004068 263.0
TLS2_k127_4837030_2 Two component transcriptional regulator, LytTR family K02477,K07705 - - 0.0000000000000000000000000000000000000000000000006769 180.0
TLS2_k127_4837030_3 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000005153 192.0
TLS2_k127_4837030_4 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000004395 158.0
TLS2_k127_4837030_5 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000455 150.0
TLS2_k127_4837501_0 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004543 543.0
TLS2_k127_4837501_1 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002654 273.0
TLS2_k127_4837501_2 Cytochrome c - - - 0.00000000000000000000000000000000000000000000008193 179.0
TLS2_k127_4837501_3 Cytochrome c K02305 - - 0.00000004323 62.0
TLS2_k127_4837591_0 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 5.231e-232 724.0
TLS2_k127_4837591_1 CoA carboxylase activity K01968 - 6.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 549.0
TLS2_k127_4837591_2 Enoyl-CoA hydratase/isomerase K13766,K13779 - 4.2.1.18,4.2.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000004946 255.0
TLS2_k127_4837591_3 COG0119 Isopropylmalate homocitrate citramalate synthases K01640 - 4.1.3.4 0.0000000000000000000000000001181 120.0
TLS2_k127_4837591_4 carboxylase K01968,K13777 - 6.4.1.4,6.4.1.5 0.000000000000693 77.0
TLS2_k127_4839068_0 Tetratricopeptide repeat K08884,K12132 - 2.7.11.1 2.096e-259 826.0
TLS2_k127_4839068_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 2.257e-254 793.0
TLS2_k127_4839068_10 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000004672 131.0
TLS2_k127_4839068_11 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.0000000000000000000000000007866 128.0
TLS2_k127_4839068_12 TIGRFAM TonB family protein K03832 - - 0.000000000000000000000000004492 123.0
TLS2_k127_4839068_13 TIGRFAM VWFA-related Acidobacterial domain - - - 0.00000000000000000000000005879 121.0
TLS2_k127_4839068_14 Sigma-70 region 2 K03088 - - 0.00000000000000000003008 98.0
TLS2_k127_4839068_16 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000002853 67.0
TLS2_k127_4839068_2 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 2.038e-201 647.0
TLS2_k127_4839068_3 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 4.774e-199 651.0
TLS2_k127_4839068_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000649 547.0
TLS2_k127_4839068_5 Elongation factor SelB, winged helix K03833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003085 490.0
TLS2_k127_4839068_6 LytB protein K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007043 314.0
TLS2_k127_4839068_7 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002547 288.0
TLS2_k127_4839068_8 Cell division ATP-binding protein ftsE K09811,K09812 GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531 - 0.00000000000000000000000000000000000000000000000000000000000000000000000232 254.0
TLS2_k127_4839068_9 DNA-templated transcription, initiation K02405 - - 0.0000000000000000000000000000000000000000000001869 181.0
TLS2_k127_4839469_0 Di-haem cytochrome c peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 417.0
TLS2_k127_4839469_1 Protein of unknown function (DUF1684) K09164 - - 0.0000000000000000000000000000000000007956 143.0
TLS2_k127_4849954_0 Protein of unknown function (DUF1264) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008858 300.0
TLS2_k127_4849954_1 Appr-1'-p processing enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000002473 221.0
TLS2_k127_4849954_2 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) - - - 0.000000000000000000000000000000000000000000002055 171.0
TLS2_k127_4849954_3 PFAM OsmC family protein K07397 - - 0.00000000000000000000000000000003354 131.0
TLS2_k127_4849954_4 PFAM PEGA domain - - - 0.000000005495 66.0
TLS2_k127_4853290_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 499.0
TLS2_k127_4853290_1 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000586 229.0
TLS2_k127_4853290_2 ABC transporter transmembrane region K06147 - - 0.0000168 47.0
TLS2_k127_4865330_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 520.0
TLS2_k127_4865330_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009968 404.0
TLS2_k127_4865330_2 phosphoprotein phosphatase activity K14680 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000004602 233.0
TLS2_k127_4865330_3 protein flavinylation K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000033 249.0
TLS2_k127_4865330_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000002013 220.0
TLS2_k127_4865330_5 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000001126 223.0
TLS2_k127_4865330_6 TIGRFAM cytochrome c nitrate reductase, small subunit K15876 - - 0.000000000000000000000000000000000000000000000000009727 182.0
TLS2_k127_4865330_7 CHRD domain - - - 0.0000000000000000000000000000000000000001544 166.0
TLS2_k127_4865330_8 Domain of unknown function (DUF4440) - - - 0.0001156 51.0
TLS2_k127_4868932_0 aminopeptidase - - - 2.114e-212 673.0
TLS2_k127_4868932_1 MacB-like periplasmic core domain - - - 2.001e-209 681.0
TLS2_k127_4868932_10 recA bacterial DNA recombination protein - - - 0.00000000000000000000002853 112.0
TLS2_k127_4868932_2 cytochrome C peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003434 494.0
TLS2_k127_4868932_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 474.0
TLS2_k127_4868932_4 Bacterial Ig-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 473.0
TLS2_k127_4868932_5 6-phosphogluconolactonase glucosamine-6-phosphate isomerase deaminase K02564 - 3.5.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 301.0
TLS2_k127_4868932_6 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009285 294.0
TLS2_k127_4868932_7 xylan catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000004738 262.0
TLS2_k127_4868932_8 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K14161 - - 0.0000000000000000000000000000000000000000000000000000000000000002478 241.0
TLS2_k127_4868932_9 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000002306 164.0
TLS2_k127_4872813_0 - - - - 0.00000000000000000000000000000000000000000000000000001055 199.0
TLS2_k127_4872813_1 - - - - 0.00000000000000000000002523 114.0
TLS2_k127_4881598_0 Hep Hag repeat protein K01179,K01207 - 3.2.1.4,3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006652 379.0
TLS2_k127_4881598_1 - - - - 0.000458 48.0
TLS2_k127_4882507_0 Heat shock 70 kDa protein K04043 - - 1.065e-296 922.0
TLS2_k127_4882507_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 587.0
TLS2_k127_4882507_10 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 311.0
TLS2_k127_4882507_11 GTPase activity K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008747 308.0
TLS2_k127_4882507_12 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001695 283.0
TLS2_k127_4882507_13 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001528 274.0
TLS2_k127_4882507_14 ABC transporter K02003,K05685 - - 0.000000000000000000000000000000000000000000000000000000000001419 233.0
TLS2_k127_4882507_15 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000001692 218.0
TLS2_k127_4882507_16 IstB-like ATP binding protein K02315 - - 0.000000000000000000000000000000000000000000000000000000003157 211.0
TLS2_k127_4882507_17 FecR protein - - - 0.000000000000000000000000000000000000000000003013 188.0
TLS2_k127_4882507_18 peptidase C26 K07010 - - 0.000000000000000000000000000000000000000002797 179.0
TLS2_k127_4882507_19 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000001699 166.0
TLS2_k127_4882507_2 Transglycosylase K05366 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005951 572.0
TLS2_k127_4882507_20 Protein of Unknown function (DUF2784) - - - 0.000000000000000000000000000000000000001159 153.0
TLS2_k127_4882507_21 Transcriptional regulator, MerR family K13640 GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000001896 159.0
TLS2_k127_4882507_22 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000006164 154.0
TLS2_k127_4882507_23 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000002756 124.0
TLS2_k127_4882507_24 Sporulation related domain - - - 0.0000002286 63.0
TLS2_k127_4882507_3 ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 534.0
TLS2_k127_4882507_4 lipoprotein localization to outer membrane K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 548.0
TLS2_k127_4882507_5 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 467.0
TLS2_k127_4882507_6 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 414.0
TLS2_k127_4882507_7 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 347.0
TLS2_k127_4882507_8 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 359.0
TLS2_k127_4882507_9 Lipocalin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005031 355.0
TLS2_k127_4882628_0 - - - - 0.000000000000000000000000000000000000001626 154.0
TLS2_k127_4882628_1 Protein of unknown function DUF45 K07043 - - 0.00000000000000000000000000000000000001579 151.0
TLS2_k127_4884850_0 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 571.0
TLS2_k127_4884850_1 N-acetylglucosaminylinositol deacetylase activity K22135 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007681 274.0
TLS2_k127_4884850_2 DinB family - - - 0.000000000000000000000000000000000000001324 155.0
TLS2_k127_4885724_0 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006881 412.0
TLS2_k127_4885724_1 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009586 404.0
TLS2_k127_4885724_10 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000008339 223.0
TLS2_k127_4885724_11 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.000000000000000000000000000000000000000000000000000426 194.0
TLS2_k127_4885724_12 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.000000000000000000000000000000000000000000000000002141 193.0
TLS2_k127_4885724_13 trans-aconitate 2-methyltransferase activity K02169 - 2.1.1.197 0.000000000000000000000000000000000000000000000000004977 194.0
TLS2_k127_4885724_14 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000006508 201.0
TLS2_k127_4885724_15 PFAM OmpA K02557 - - 0.00000000000000000000000000000000000000000000119 185.0
TLS2_k127_4885724_16 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000002729 173.0
TLS2_k127_4885724_17 Flagella basal body rod protein K02391,K02392 - - 0.000000000000000000000000000000000000008136 158.0
TLS2_k127_4885724_18 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.00000000000000000000000000000000000006613 152.0
TLS2_k127_4885724_19 Haloacid dehalogenase-like hydrolase K07025 - - 0.000000000000000000000000000000004774 146.0
TLS2_k127_4885724_2 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000442 347.0
TLS2_k127_4885724_20 PFAM acylneuraminate cytidylyltransferase K07257 - - 0.00000000000000000000000000001966 134.0
TLS2_k127_4885724_21 Rod binding protein K21471 - - 0.00000000000000000000000000005038 132.0
TLS2_k127_4885724_22 Bacterial flagellin N-terminal helical region K02397 - - 0.000000000000000000008373 108.0
TLS2_k127_4885724_23 flagellar protein FliS K02422 - - 0.00000000000000000003111 102.0
TLS2_k127_4885724_24 Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum K13626 - - 0.00000000000000003617 93.0
TLS2_k127_4885724_25 PFAM glycosyl transferase group 1 - - - 0.00000000000000005809 94.0
TLS2_k127_4885724_26 Zinc ion binding K11997,K12035 GO:0003008,GO:0003012,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007610,GO:0007626,GO:0008150,GO:0008152,GO:0008270,GO:0008345,GO:0009653,GO:0009987,GO:0010927,GO:0016043,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030239,GO:0030537,GO:0031032,GO:0031674,GO:0032446,GO:0032501,GO:0032502,GO:0032989,GO:0036211,GO:0042592,GO:0042692,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044464,GO:0046716,GO:0046872,GO:0046914,GO:0048468,GO:0048646,GO:0048747,GO:0048856,GO:0048869,GO:0051146,GO:0055001,GO:0055002,GO:0060249,GO:0061061,GO:0065007,GO:0065008,GO:0070647,GO:0070925,GO:0071704,GO:0071840,GO:0097435,GO:0099080,GO:0099081,GO:0099512,GO:0140096,GO:1901564 2.3.2.27 0.000000000000000139 92.0
TLS2_k127_4885724_27 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 GO:0001539,GO:0003674,GO:0005198,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 - 0.0000000000001502 83.0
TLS2_k127_4885724_28 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding K03563 - - 0.00000000000324 71.0
TLS2_k127_4885724_29 PFAM flagellar FlbD family protein K02385 - - 0.00000000008125 71.0
TLS2_k127_4885724_3 Flagella basal body rod protein K02392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 301.0
TLS2_k127_4885724_30 Acetyltransferase (GNAT) domain - - - 0.00000001382 67.0
TLS2_k127_4885724_31 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.00000003163 63.0
TLS2_k127_4885724_32 Spore coat polysaccharide biosynthesis protein - - - 0.0000003179 64.0
TLS2_k127_4885724_33 - - - - 0.000003247 57.0
TLS2_k127_4885724_34 Drug exporters of the RND superfamily K06994,K07003 - - 0.00002135 54.0
TLS2_k127_4885724_4 Polysaccharide biosynthesis protein K01710,K15894 - 4.2.1.115,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000005863 254.0
TLS2_k127_4885724_5 DUF based on E. rectale Gene description (DUF3880) K06320 - - 0.000000000000000000000000000000000000000000000000000000000000000000005161 257.0
TLS2_k127_4885724_6 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001809 234.0
TLS2_k127_4885724_7 PFAM MotA TolQ ExbB proton channel K02556 - - 0.000000000000000000000000000000000000000000000000000000000000001426 232.0
TLS2_k127_4885724_8 TIGRFAM flagellar hook-associated protein FlgK K02396 - - 0.00000000000000000000000000000000000000000000000000000000000003477 235.0
TLS2_k127_4885724_9 COG2089 Sialic acid synthase - - - 0.0000000000000000000000000000000000000000000000000000000000008687 233.0
TLS2_k127_4892714_0 Fungalysin metallopeptidase (M36) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 586.0
TLS2_k127_4892714_1 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000009246 74.0
TLS2_k127_4893206_0 lipoprotein localization to outer membrane K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 449.0
TLS2_k127_4893206_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 379.0
TLS2_k127_4893206_2 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000001343 212.0
TLS2_k127_4893206_3 thiolester hydrolase activity K06889 - - 0.000000000000000000000000000000001586 142.0
TLS2_k127_4893206_4 BAAT / Acyl-CoA thioester hydrolase C terminal K06889 - - 0.0000000003478 70.0
TLS2_k127_4893206_5 peptide catabolic process K01256 - 3.4.11.2 0.000003065 58.0
TLS2_k127_4909022_0 FtsX-like permease family - - - 5.079e-194 646.0
TLS2_k127_4909022_1 Aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007765 480.0
TLS2_k127_4909022_2 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 466.0
TLS2_k127_4909022_3 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 337.0
TLS2_k127_4909022_4 PQQ-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003116 308.0
TLS2_k127_4909022_5 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K02003,K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000435 264.0
TLS2_k127_4909022_6 Rhodanese-like domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000008864 249.0
TLS2_k127_4909022_7 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000001242 173.0
TLS2_k127_4909022_8 - - - - 0.000000000000000000007804 105.0
TLS2_k127_4912426_0 DoxX - - - 0.00000000000000000000000000000000000000000000000000002817 191.0
TLS2_k127_4912426_1 PFAM amino acid permease-associated region K03294 - - 0.00000000000000000000000000000000131 141.0
TLS2_k127_4912426_2 dicarboxylic acid transport K11102 - - 0.000000000000000000000000000001013 135.0
TLS2_k127_491632_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 412.0
TLS2_k127_491632_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 316.0
TLS2_k127_491632_10 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000004944 56.0
TLS2_k127_491632_2 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004705 260.0
TLS2_k127_491632_3 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.0000000000000000000000000000000000000000000000000000000000000000007645 230.0
TLS2_k127_491632_4 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000009433 186.0
TLS2_k127_491632_5 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 - - 0.0000000000000000000000000000000000000000000000001234 194.0
TLS2_k127_491632_6 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000000000004671 151.0
TLS2_k127_491632_7 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000001006 125.0
TLS2_k127_491632_8 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000000001055 113.0
TLS2_k127_491632_9 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000002716 66.0
TLS2_k127_4921851_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 1.024e-309 960.0
TLS2_k127_4921851_1 Dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 569.0
TLS2_k127_4921851_10 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000001876 233.0
TLS2_k127_4921851_11 Domain of unknown function K07053 - 3.1.3.97 0.00000000000000000000000000000000000000000000000000000000000000363 235.0
TLS2_k127_4921851_12 Predicted membrane protein (DUF2238) K08984 - - 0.000000000000000000000000000000000000000000000000000000000000009958 225.0
TLS2_k127_4921851_13 Histidine kinase-like ATPase domain K01338,K04757,K06379,K08282,K17752 - 2.7.11.1,3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000105 219.0
TLS2_k127_4921851_14 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000000001056 201.0
TLS2_k127_4921851_15 Zinc-binding dehydrogenase K00004,K00008 - 1.1.1.14,1.1.1.303,1.1.1.4 0.000000000000000000000000000000000000000000000000000003246 203.0
TLS2_k127_4921851_16 - - - - 0.0000000000000000000000000000000000000000000000000001547 192.0
TLS2_k127_4921851_17 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000001684 146.0
TLS2_k127_4921851_18 Cupin 2, conserved barrel domain protein - - - 0.00000000000000007707 91.0
TLS2_k127_4921851_19 WD40-like Beta Propeller Repeat - - - 0.00014 47.0
TLS2_k127_4921851_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 558.0
TLS2_k127_4921851_20 Alpha beta hydrolase - - - 0.0003497 47.0
TLS2_k127_4921851_3 COGs COG4299 conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 528.0
TLS2_k127_4921851_4 PFAM FG-GAP repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 375.0
TLS2_k127_4921851_5 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) K01083 - 3.1.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009685 303.0
TLS2_k127_4921851_6 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA K04799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004678 295.0
TLS2_k127_4921851_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000101 284.0
TLS2_k127_4921851_8 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004484 252.0
TLS2_k127_4921851_9 Phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002302 250.0
TLS2_k127_4926230_0 oxidoreductase activity - - - 0.0000000000000000000000005046 121.0
TLS2_k127_4926230_1 TIGRFAM VWFA-related Acidobacterial domain - - - 0.0000000000000000269 96.0
TLS2_k127_4962048_0 PFAM Pyrrolo-quinoline quinone K00117 - 1.1.5.2 1.124e-272 862.0
TLS2_k127_4962048_1 PFAM inositol monophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 289.0
TLS2_k127_4990491_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.518e-259 808.0
TLS2_k127_4990491_1 PFAM SAICAR synthetase K01923,K13713 - 6.3.2.6,6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004918 383.0
TLS2_k127_4990491_2 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000001935 215.0
TLS2_k127_4990491_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.00000000000000000000000000000000000004253 145.0
TLS2_k127_4990491_4 lysyltransferase activity K07027 - - 0.000000000000000000000000000000000001236 154.0
TLS2_k127_4990491_5 PFAM helix-turn-helix, Fis-type - - - 0.0000004776 58.0
TLS2_k127_4990491_6 Domain of unknown function (DUF4390) - - - 0.000002242 55.0
TLS2_k127_4992420_0 AcrB/AcrD/AcrF family - - - 0.0 1223.0
TLS2_k127_4992420_1 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000008361 222.0
TLS2_k127_4992420_2 HlyD family secretion protein - - - 0.00000000000000000000000000000000000000000000008132 190.0
TLS2_k127_4992420_3 heme-binding domain, Pirellula Verrucomicrobium type - - - 0.000000000000000000000000000000000000001339 160.0
TLS2_k127_4992420_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000005057 128.0
TLS2_k127_4992420_5 Protein of unknown function (DUF2892) - - - 0.00000000000000000002236 92.0
TLS2_k127_4992420_6 Belongs to the universal stress protein A family - - - 0.000000001023 69.0
TLS2_k127_4992420_7 Putative zinc-finger - - - 0.00002359 55.0
TLS2_k127_4993047_0 choline dehydrogenase activity - - - 2.61e-259 812.0
TLS2_k127_4993047_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 380.0
TLS2_k127_4993047_2 lipopolysaccharide transport K22110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005956 352.0
TLS2_k127_4993047_3 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001359 281.0
TLS2_k127_4993047_4 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.0007647 44.0
TLS2_k127_5001894_0 PFAM sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 459.0
TLS2_k127_5001894_1 Integrase core domain K07497 - - 0.000000000000000000000000000000000004627 142.0
TLS2_k127_5001894_2 Transposase K07497 - - 0.0000000000000000000000000000000119 129.0
TLS2_k127_5001894_3 Integrase core domain K07497 - - 0.00000000000000000000004527 104.0
TLS2_k127_5001894_4 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00000004323 62.0
TLS2_k127_5003599_0 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 367.0
TLS2_k127_5003599_1 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000000005375 188.0
TLS2_k127_5013787_0 Cytochrome c - - - 0.0 1684.0
TLS2_k127_5013787_1 Glycosyl hydrolases family 32 K03332 - 3.2.1.80 2.085e-214 681.0
TLS2_k127_5013787_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 434.0
TLS2_k127_5013787_3 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.00000000000000000000000000000000000000000000000000000000000001578 233.0
TLS2_k127_5013787_4 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) K08680 - 4.2.99.20 0.0000000000000000000000000000000000000000000000001171 184.0
TLS2_k127_5013787_5 Fungal family of unknown function (DUF1776) - - - 0.0000000000000000000000000000000000000000000007938 175.0
TLS2_k127_5013787_6 KR domain - - - 0.000000000005184 71.0
TLS2_k127_5020510_0 phosphoenolpyruvate-dependent sugar phosphotransferase system - - - 0.000000000000000001282 91.0
TLS2_k127_5020510_1 - - - - 0.00003116 56.0
TLS2_k127_5025352_0 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 446.0
TLS2_k127_5025352_1 Methyltransferase domain - - - 0.0000000000000000000000000000006736 136.0
TLS2_k127_5025352_2 High confidence in function and specificity - - - 0.000000000000000002221 88.0
TLS2_k127_5032909_0 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000004918 249.0
TLS2_k127_5032909_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000004696 161.0
TLS2_k127_5045309_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 2.621e-269 856.0
TLS2_k127_5045309_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007722 525.0
TLS2_k127_5045309_10 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000006432 162.0
TLS2_k127_5045309_11 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000001854 144.0
TLS2_k127_5045309_12 thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004550,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006139,GO:0006165,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000003237 138.0
TLS2_k127_5045309_13 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.00000000000000000000000000000003989 132.0
TLS2_k127_5045309_14 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000001526 130.0
TLS2_k127_5045309_15 radical SAM domain protein - - - 0.0000000000000000000002918 111.0
TLS2_k127_5045309_16 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000006567 94.0
TLS2_k127_5045309_19 Methyltransferase domain - - - 0.00000416 59.0
TLS2_k127_5045309_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 421.0
TLS2_k127_5045309_20 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0001101 52.0
TLS2_k127_5045309_3 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006469 377.0
TLS2_k127_5045309_4 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 364.0
TLS2_k127_5045309_5 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004598 330.0
TLS2_k127_5045309_6 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 291.0
TLS2_k127_5045309_7 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008673 270.0
TLS2_k127_5045309_8 TIGRFAM DNA protecting protein DprA K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000002586 241.0
TLS2_k127_5045309_9 RNA polymerase sigma factor K03088 - - 0.0000000000000000000000000000000000000000001202 168.0
TLS2_k127_50611_0 helicase activity - - - 2.178e-271 865.0
TLS2_k127_50611_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006679 561.0
TLS2_k127_50611_10 Uncharacterised protein family (UPF0158) - - - 0.0007939 51.0
TLS2_k127_50611_2 aldo keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007918 287.0
TLS2_k127_50611_3 AAA domain - - - 0.0000000000000000000000000000000000003287 151.0
TLS2_k127_50611_4 BMC - - - 0.00000000000000000000000000000001703 133.0
TLS2_k127_50611_5 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.000000000000000000000000005074 117.0
TLS2_k127_50611_6 FAD dependent oxidoreductase K03153 - 1.4.3.19 0.000000000000000000000001212 106.0
TLS2_k127_50611_7 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000004 97.0
TLS2_k127_50611_8 -acetyltransferase - - - 0.000000008524 67.0
TLS2_k127_50611_9 - - - - 0.000000727 61.0
TLS2_k127_5079580_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 528.0
TLS2_k127_5079580_1 Protein of unknown function (DUF3641) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 435.0
TLS2_k127_5079580_2 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000007338 216.0
TLS2_k127_5079580_3 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000002082 167.0
TLS2_k127_5079580_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.00000000000000000000000000000000000000002678 156.0
TLS2_k127_5079580_5 Cupredoxin-like domain - - - 0.000000005089 63.0
TLS2_k127_5105706_0 COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - 2.042e-253 793.0
TLS2_k127_5105706_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004239 351.0
TLS2_k127_5105706_2 nitric oxide dioxygenase activity K00523,K15983 - 1.14.13.142,1.17.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 333.0
TLS2_k127_5114028_0 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000001602 245.0
TLS2_k127_5114028_1 PFAM histone deacetylase superfamily - - - 0.00000000000000000000000000000000000000000158 160.0
TLS2_k127_5114028_2 Tetratricopeptide repeat - - - 0.0000000000008586 81.0
TLS2_k127_5114028_3 - - - - 0.0000008618 59.0
TLS2_k127_5115368_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000648 469.0
TLS2_k127_5115368_1 BNR repeat-like domain K05989 - 3.2.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 429.0
TLS2_k127_5115368_2 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009537 276.0
TLS2_k127_5115368_3 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000005587 253.0
TLS2_k127_5115368_4 Predicted membrane protein (DUF2231) - - - 0.000000000000000000000000000000000000000000000000000000000000000000009367 244.0
TLS2_k127_5115368_5 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000004685 54.0
TLS2_k127_5119421_0 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000366 191.0
TLS2_k127_5119421_1 Protein of unknown function (DUF3047) - - - 0.00000000000000000006358 90.0
TLS2_k127_5140154_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 2.623e-319 1000.0
TLS2_k127_5140154_1 PFAM ATPase associated with various cellular activities, AAA_5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000482 381.0
TLS2_k127_5140154_2 SMART von Willebrand factor, type A K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 351.0
TLS2_k127_5140154_3 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000001355 232.0
TLS2_k127_5140154_4 CO dehydrogenase flavoprotein C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000007489 225.0
TLS2_k127_5140154_5 PFAM carbon monoxide dehydrogenase subunit G K09386 - - 0.00000000001101 72.0
TLS2_k127_5140154_6 acyl-CoA dehydrogenase K22027 - 1.14.13.235 0.00000000522 61.0
TLS2_k127_5142587_0 Converts alpha-aldose to the beta-anomer K01785 - 5.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 481.0
TLS2_k127_5142587_1 Glycosyl hydrolases family 16 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 342.0
TLS2_k127_5142587_2 Rubrerythrin K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000009467 246.0
TLS2_k127_5142587_3 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000007915 213.0
TLS2_k127_5142587_4 PFAM Polysaccharide deacetylase - - - 0.0000000000000000000000000000007137 128.0
TLS2_k127_5164594_0 Short chain fatty acid transporter K02106 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 509.0
TLS2_k127_5164594_1 Phosphoinositide phospholipase C, Ca2+-dependent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 332.0
TLS2_k127_517280_0 efflux transmembrane transporter activity - - - 1.134e-196 640.0
TLS2_k127_517280_1 alpha-L-arabinofuranosidase K01209 - 3.2.1.55 0.0000000000000000001077 93.0
TLS2_k127_5173260_0 topoisomerase K02469 - 5.99.1.3 2.286e-281 884.0
TLS2_k127_5185434_0 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 590.0
TLS2_k127_5185434_1 Hydantoinase B/oxoprolinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 569.0
TLS2_k127_5185434_2 metal-dependent hydrolase with the TIM-barrel fold - - - 0.00000000000000000000003226 105.0
TLS2_k127_5185434_3 Malate/L-lactate dehydrogenase - - - 0.00000000001137 71.0
TLS2_k127_5185434_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00001316 53.0
TLS2_k127_5194696_0 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004299 392.0
TLS2_k127_5194696_1 Subtilase family K17734 - - 0.0000000000000000000000000000000000000000000000000000002117 216.0
TLS2_k127_5207983_0 choline dehydrogenase activity - - - 1.218e-256 803.0
TLS2_k127_5207983_1 Efflux ABC transporter permease protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 386.0
TLS2_k127_5207983_2 Glycosyl transferase family 2 K11936,K14666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003976 374.0
TLS2_k127_5207983_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 305.0
TLS2_k127_5207983_4 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002345 294.0
TLS2_k127_5207983_5 Protein of unknown function (DUF1499) - - - 0.000000000000000000000000000000000000000000000000000000000000002326 226.0
TLS2_k127_5207983_7 Putative heavy-metal-binding - - - 0.00000000000000000302 85.0
TLS2_k127_5207983_8 Tetratricopeptide repeat - - - 0.0003668 53.0
TLS2_k127_5208192_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00007762 55.0
TLS2_k127_521229_0 PFAM Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 484.0
TLS2_k127_521229_1 domain protein K14194 - - 0.0000001969 63.0
TLS2_k127_5213096_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 6.782e-319 997.0
TLS2_k127_5213096_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 4.088e-294 926.0
TLS2_k127_5213096_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 503.0
TLS2_k127_5213096_3 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 314.0
TLS2_k127_5213096_4 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.000003361 53.0
TLS2_k127_5224178_0 Glycosyl hydrolases family 15 - - - 4.928e-267 834.0
TLS2_k127_5224178_1 beta-galactosidase activity K01190,K01219,K12308 - 3.2.1.23,3.2.1.81 1.565e-226 722.0
TLS2_k127_5224178_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000003951 71.0
TLS2_k127_5224178_2 Glucuronate isomerase K01812 - 5.3.1.12 6.822e-196 624.0
TLS2_k127_5224178_3 transmembrane transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004282 430.0
TLS2_k127_5224178_4 myo-inosose-2 dehydratase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003446 422.0
TLS2_k127_5224178_5 Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 419.0
TLS2_k127_5224178_6 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009666 327.0
TLS2_k127_5224178_7 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 324.0
TLS2_k127_5224178_8 WYL domain K13572 - - 0.000000000000000000000000000000000000000002472 169.0
TLS2_k127_5224178_9 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000002426 148.0
TLS2_k127_5229937_0 Acetolactate synthase, large subunit K01652 - 2.2.1.6 7.549e-294 910.0
TLS2_k127_5229937_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 8.211e-236 754.0
TLS2_k127_5229937_10 - - - - 0.00000000000000000000006215 103.0
TLS2_k127_5229937_2 Fumarylacetoacetate (FAA) hydrolase K01555 - 3.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 580.0
TLS2_k127_5229937_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 509.0
TLS2_k127_5229937_4 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006691 456.0
TLS2_k127_5229937_5 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 355.0
TLS2_k127_5229937_6 amino acid-binding ACT domain protein K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 293.0
TLS2_k127_5229937_7 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000125 213.0
TLS2_k127_5229937_8 RsgA GTPase K06949 - 3.1.3.100 0.000000000000000000000000000000000000000000004175 170.0
TLS2_k127_5229937_9 - - - - 0.000000000000000000000000229 112.0
TLS2_k127_5235836_0 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 349.0
TLS2_k127_5235836_1 Serine threonine protein kinase involved in cell cycle control - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 332.0
TLS2_k127_5235836_2 - - - - 0.000000000000000000000000000000000000000000009936 175.0
TLS2_k127_5235836_3 Protein of unknown function (DUF3037) - - - 0.00000000000000000000000000007267 119.0
TLS2_k127_5238855_0 Protein of unknown function (DUF1343) - - - 1.841e-238 762.0
TLS2_k127_5238855_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 374.0
TLS2_k127_5238855_2 PFAM Peptidase M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006353 289.0
TLS2_k127_5238855_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002309 282.0
TLS2_k127_5238855_4 Protein of unknown function (DUF420) K08976 - - 0.00000000000000000000000000000000000000000008252 165.0
TLS2_k127_5238855_5 HIT family hydrolase, diadenosine tetraphosphate hydrolase - - - 0.00000000000000000000000000000000003723 139.0
TLS2_k127_5238855_6 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000001709 130.0
TLS2_k127_5262967_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 414.0
TLS2_k127_5262967_1 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007983 395.0
TLS2_k127_5262967_2 UbiA prenyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 316.0
TLS2_k127_5262967_3 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003143 309.0
TLS2_k127_5262967_4 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000000000000003017 151.0
TLS2_k127_5262967_5 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.000000000000000000000000000000001352 134.0
TLS2_k127_5262967_6 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.000000000000000000000001191 105.0
TLS2_k127_5262967_7 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.0000000000001811 72.0
TLS2_k127_5306909_0 Phosphate acyltransferases K00655,K01897 - 2.3.1.51,6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001876 293.0
TLS2_k127_5306909_1 Histone methylation protein DOT1 - - - 0.000000000000000000000000000000000000000000000000000000001421 210.0
TLS2_k127_5306909_2 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.00000000000000000000000000000000000001606 155.0
TLS2_k127_5306909_3 CarD-like/TRCF domain K07736 - - 0.00000000000000000000000000000000000005461 155.0
TLS2_k127_532496_0 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 617.0
TLS2_k127_532496_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007924 585.0
TLS2_k127_532496_10 protein-glutamate methylesterase activity K00575,K03412,K03413 - 2.1.1.80,3.1.1.61,3.5.1.44 0.00009831 53.0
TLS2_k127_532496_2 Protein of unknown function (DUF418) K07148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003778 263.0
TLS2_k127_532496_3 DoxX K15977 - - 0.0000000000000000000000000005717 119.0
TLS2_k127_532496_4 Protein of unknown function (DUF3365) - - - 0.00000000000000000000005449 108.0
TLS2_k127_532496_5 PFAM GGDEF domain containing protein K13590 - 2.7.7.65 0.000000000000000005864 95.0
TLS2_k127_532496_6 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000001223 88.0
TLS2_k127_532496_7 chromosome segregation K03497 - - 0.000000000001755 79.0
TLS2_k127_532496_8 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.00000005281 59.0
TLS2_k127_532496_9 His Kinase A (phosphoacceptor) domain - - - 0.000005265 57.0
TLS2_k127_5326441_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 8.944e-246 772.0
TLS2_k127_5326441_1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005293 308.0
TLS2_k127_5326441_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000119 167.0
TLS2_k127_5326441_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000000000003394 156.0
TLS2_k127_5326441_4 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000001678 130.0
TLS2_k127_5327343_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007227 557.0
TLS2_k127_5327343_1 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003898 441.0
TLS2_k127_5327343_2 negative regulation of transcription, DNA-templated K10947 - - 0.0000000000000000000000003436 109.0
TLS2_k127_5327343_3 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000002974 113.0
TLS2_k127_5327343_4 AAA ATPase domain - - - 0.0000000000000000000001457 113.0
TLS2_k127_5327343_5 membrane - - - 0.0000000002139 70.0
TLS2_k127_5333_0 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000007708 269.0
TLS2_k127_5333_1 Trehalose utilisation K09992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000159 258.0
TLS2_k127_5333_2 glucose sorbosone - - - 0.0000000000000497 83.0
TLS2_k127_5337286_0 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007168 270.0
TLS2_k127_5358892_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 350.0
TLS2_k127_5358892_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 315.0
TLS2_k127_5358892_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000003588 79.0
TLS2_k127_5385648_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000495 397.0
TLS2_k127_5385648_1 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 300.0
TLS2_k127_5385648_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001353 292.0
TLS2_k127_5385648_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007879 271.0
TLS2_k127_5385648_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K11928 - - 0.00000000000000000000000000000000000000000000000000003175 203.0
TLS2_k127_5385648_5 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.0000000001254 70.0
TLS2_k127_5385648_6 Cro/C1-type HTH DNA-binding domain - - - 0.0004608 48.0
TLS2_k127_5400069_0 Belongs to the glycosyl hydrolase 43 family K01198,K01209 - 3.2.1.37,3.2.1.55 3.045e-219 696.0
TLS2_k127_5400069_1 PFAM Methylated-DNA- protein -cysteine S-methyltransferase, DNA binding K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 464.0
TLS2_k127_5400069_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000008348 241.0
TLS2_k127_5400069_3 Flavin reductase like domain - - - 0.000000000002877 68.0
TLS2_k127_5404336_0 dehydrogenases and related proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006555 398.0
TLS2_k127_5419425_0 PFAM Amidase - - - 8.904e-198 656.0
TLS2_k127_5419425_1 Glycoside hydrolase 97 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 535.0
TLS2_k127_5419425_2 polysaccharide catabolic process K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 308.0
TLS2_k127_5419425_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005184 302.0
TLS2_k127_54349_0 Two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 513.0
TLS2_k127_54349_1 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 364.0
TLS2_k127_54349_2 PFAM Formiminotransferase K00603 - 2.1.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002763 334.0
TLS2_k127_54349_3 Belongs to the CinA family K03742,K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 317.0
TLS2_k127_54349_4 histidine kinase, HAMP K13598 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000001349 255.0
TLS2_k127_54349_5 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000000000416 119.0
TLS2_k127_54349_6 RDD family - - - 0.0000005462 63.0
TLS2_k127_5436219_0 Histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 333.0
TLS2_k127_5436219_1 Domain of unknown function (DUF4154) - - - 0.00000000000000000000001499 108.0
TLS2_k127_544327_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 9.151e-240 745.0
TLS2_k127_544327_1 Domain of Unknown Function (DUF349) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 346.0
TLS2_k127_544327_2 Cupin 2 conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000001482 226.0
TLS2_k127_544327_3 methyltransferase K21459 - 2.1.1.301 0.0000000000000000000000000000000000000000000006555 177.0
TLS2_k127_544327_4 GDSL-like lipase acylhydrolase domain protein - - - 0.0000000000000000000000000000000000000006223 161.0
TLS2_k127_5521231_0 histidine kinase, HAMP K13598 - 2.7.13.3 0.0000000000000000000000000000000000000000000000003348 195.0
TLS2_k127_55935_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007053 505.0
TLS2_k127_55935_1 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007057 299.0
TLS2_k127_55935_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000007088 186.0
TLS2_k127_55935_3 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000001022 140.0
TLS2_k127_55935_4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.00000000000000000000000001533 117.0
TLS2_k127_55935_5 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000004037 96.0
TLS2_k127_55935_6 KH domain - - - 0.0000000000005472 78.0
TLS2_k127_55935_7 - - - - 0.00003883 53.0
TLS2_k127_55935_8 Tetratricopeptide repeat - - - 0.0000497 56.0
TLS2_k127_5616723_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003912 601.0
TLS2_k127_5616723_1 alcohol dehydrogenase K00001,K00121 GO:0001505,GO:0003008,GO:0003674,GO:0003824,GO:0004022,GO:0004552,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0007610,GO:0007611,GO:0007612,GO:0007632,GO:0008150,GO:0008152,GO:0008306,GO:0008542,GO:0009314,GO:0009416,GO:0009628,GO:0016491,GO:0016614,GO:0016616,GO:0016651,GO:0016657,GO:0019222,GO:0031323,GO:0031399,GO:0032268,GO:0032501,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050877,GO:0050890,GO:0050896,GO:0051171,GO:0051246,GO:0051903,GO:0055114,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080007,GO:0080090,GO:0080164,GO:1901615,GO:2000169,GO:2000377 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000001264 209.0
TLS2_k127_5617982_0 DEAD DEAH box helicase K03654 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 609.0
TLS2_k127_5617982_1 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009259 468.0
TLS2_k127_5617982_2 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008767 433.0
TLS2_k127_5617982_3 PAP2 superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005643 270.0
TLS2_k127_5617982_4 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001216 269.0
TLS2_k127_5620735_0 threonine dehydratase K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000009423 237.0
TLS2_k127_5620735_1 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000002965 229.0
TLS2_k127_5620735_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000298 203.0
TLS2_k127_5620735_3 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000005395 208.0
TLS2_k127_5620735_4 PA domain - - - 0.00000000000000000000000000000001828 139.0
TLS2_k127_5620735_5 Forkhead associated domain - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006110,GO:0006140,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010563,GO:0010675,GO:0010677,GO:0016020,GO:0016310,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0030312,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0036211,GO:0042325,GO:0042326,GO:0042802,GO:0043170,GO:0043412,GO:0043457,GO:0043467,GO:0043470,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045820,GO:0045912,GO:0045934,GO:0045936,GO:0045980,GO:0046777,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901564,GO:1903578,GO:1903579,GO:2001169,GO:2001170 - 0.000000000002683 71.0
TLS2_k127_5620735_6 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000004803 73.0
TLS2_k127_5627343_0 CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons K01026 - 2.8.3.1 2.954e-198 635.0
TLS2_k127_5627343_1 COGs COG1680 Beta-lactamase class C and other penicillin binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 317.0
TLS2_k127_5627343_2 Uroporphyrinogen decarboxylase (URO-D) K01599,K14080 - 2.1.1.246,4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001234 283.0
TLS2_k127_5627343_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000007383 264.0
TLS2_k127_5627343_4 Methionine synthase B12-binding module cap domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000122 247.0
TLS2_k127_5627343_5 Methane oxygenase PmoA - - - 0.00000000000000000000000000000000000000000000000000000000000008805 225.0
TLS2_k127_5627343_6 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000002023 201.0
TLS2_k127_5627343_7 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000009142 186.0
TLS2_k127_5627343_8 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000001079 144.0
TLS2_k127_5627343_9 Methyltransferase domain - - - 0.000000000000000000000000005719 111.0
TLS2_k127_5641190_0 oxidoreductase activity - - - 0.000000000006333 79.0
TLS2_k127_5641190_1 oxidoreductase activity - - - 0.0000000002217 73.0
TLS2_k127_5654368_0 Rhodopirellula transposase DDE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 316.0
TLS2_k127_5654368_2 ATPase (AAA superfamily K03685,K06922 - 3.1.26.3 0.000000000000005612 76.0
TLS2_k127_5659054_0 Alpha-tubulin suppressor and related RCC1 domain-containing proteins - - - 3.075e-224 781.0
TLS2_k127_5659054_1 - - - - 0.0000000000000000000000000000000007121 137.0
TLS2_k127_5659054_2 Protein of unknown function (DUF433) - - - 0.0000000000000000000000000000002329 124.0
TLS2_k127_5659054_3 chitin catabolic process K02358,K15924 - 3.2.1.136 0.00000000000000000000000003737 129.0
TLS2_k127_5659054_4 Belongs to the 'phage' integrase family - - - 0.000000003354 63.0
TLS2_k127_5659054_5 ParE toxin of type II toxin-antitoxin system, parDE K19092 - - 0.0000001217 57.0
TLS2_k127_5659054_6 Belongs to the 'phage' integrase family - - - 0.0000005715 62.0
TLS2_k127_5663356_0 Thiamine pyrophosphate enzyme, central domain K03336 - 3.7.1.22 8.18e-242 762.0
TLS2_k127_5663356_1 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system K10441 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 491.0
TLS2_k127_5663356_2 PFAM Alcohol dehydrogenase K00001,K00008 - 1.1.1.1,1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 464.0
TLS2_k127_5663356_3 Branched-chain amino acid transport system / permease component K10439,K10440 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015591,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034219,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 345.0
TLS2_k127_5663356_4 Periplasmic binding proteins and sugar binding domain of LacI family K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 324.0
TLS2_k127_5663356_5 Oxidoreductase family, C-terminal alpha beta domain K16043 - 1.1.1.370 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007303 299.0
TLS2_k127_5663356_6 enzyme involved in inositol metabolism K03337 - 5.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000986 267.0
TLS2_k127_5663356_7 helix_turn _helix lactose operon repressor K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001027 256.0
TLS2_k127_5663356_8 PFAM von Willebrand factor type A - - - 0.000000000000000000000000000002794 133.0
TLS2_k127_5668456_0 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001116 292.0
TLS2_k127_5668456_1 Ketopantoate reductase PanE/ApbA C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002469 260.0
TLS2_k127_5668456_2 - - - - 0.00000000000000006381 86.0
TLS2_k127_5668810_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K20974 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005461 498.0
TLS2_k127_5668810_1 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 453.0
TLS2_k127_5668810_2 phosphorelay signal transduction system K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008334 444.0
TLS2_k127_5668810_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000002265 219.0
TLS2_k127_5676507_0 MacB-like periplasmic core domain - - - 2.725e-261 831.0
TLS2_k127_5676507_1 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007237 389.0
TLS2_k127_5676507_2 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000002014 191.0
TLS2_k127_5676507_3 glyoxalase III activity K02005 - - 0.0000000000000000000000000000000000000000000000002224 182.0
TLS2_k127_5676507_4 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.000000000000000000000000000000000000000000000001953 192.0
TLS2_k127_5676507_5 transcriptional regulator, ArsR family - - - 0.000000000000000000000000000000000000000000007284 167.0
TLS2_k127_5676507_6 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000002731 161.0
TLS2_k127_5676507_7 transcriptional regulator - - - 0.0000000000000000000000000000000145 142.0
TLS2_k127_5681433_0 FGGY family of carbohydrate kinases, N-terminal domain K00854 - 2.7.1.17 3.138e-208 659.0
TLS2_k127_5681433_1 Belongs to the xylose isomerase family K01805 - 5.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 600.0
TLS2_k127_5681433_2 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system K10545 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007728 444.0
TLS2_k127_5681433_3 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 331.0
TLS2_k127_5681433_4 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 283.0
TLS2_k127_5681433_5 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K06187,K09747 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363 - 0.0000000000000000000000000001967 121.0
TLS2_k127_5681528_0 Major facilitator Superfamily K08218,K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 336.0
TLS2_k127_5681528_2 - - - - 0.000000000002174 74.0
TLS2_k127_5685572_0 efflux transmembrane transporter activity - - - 6.138e-210 680.0
TLS2_k127_5685572_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003482 550.0
TLS2_k127_5685572_10 Subtilase family K17734 - - 0.00000000000000000000000000000008983 128.0
TLS2_k127_5685572_2 Na+/H+ antiporter family K03315 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 544.0
TLS2_k127_5685572_3 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000047 413.0
TLS2_k127_5685572_4 Glycosyltransferase family 28 N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 395.0
TLS2_k127_5685572_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007887 288.0
TLS2_k127_5685572_6 PhoD-like phosphatase K01113,K07093 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001514 283.0
TLS2_k127_5685572_7 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000004472 199.0
TLS2_k127_5685572_8 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000002884 188.0
TLS2_k127_5685572_9 DinB family - - - 0.000000000000000000000000000000000000000000001692 169.0
TLS2_k127_5689559_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 1.163e-256 810.0
TLS2_k127_5689559_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 1.207e-202 639.0
TLS2_k127_5689559_2 Oxidoreductase family, C-terminal alpha beta domain K13020 - 1.1.1.335 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 430.0
TLS2_k127_5689559_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000002902 212.0
TLS2_k127_5689559_4 cheY-homologous receiver domain - - - 0.000000000000000000000000001854 117.0
TLS2_k127_5689559_5 Domain of unknown function (DUF4142) K08995 - - 0.000000000000000000000003307 115.0
TLS2_k127_5689559_6 TonB-dependent Receptor Plug Domain - - - 0.000000000002939 78.0
TLS2_k127_5689559_7 multicopper - - - 0.0001108 53.0
TLS2_k127_5691141_0 Surface antigen K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002854 263.0
TLS2_k127_5691141_1 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000008802 72.0
TLS2_k127_5691141_2 Stress-induced bacterial acidophilic repeat motif K06884 - - 0.0005692 43.0
TLS2_k127_5693921_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005582 469.0
TLS2_k127_5698804_0 ABC transporter - - - 2.162e-207 667.0
TLS2_k127_5698804_1 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006746 258.0
TLS2_k127_5698804_2 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000001596 168.0
TLS2_k127_5698804_3 ABC-2 family transporter protein - - - 0.00000000000000000003074 103.0
TLS2_k127_5698804_4 von Willebrand factor, type A K07114 - - 0.00000000000001464 76.0
TLS2_k127_5703914_0 WD40 domain protein beta Propeller - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 415.0
TLS2_k127_5703914_1 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.000000000000000000000000129 116.0
TLS2_k127_5703914_2 SMART serine threonine protein kinase - - - 0.000105 52.0
TLS2_k127_5706177_0 Beta-L-arabinofuranosidase, GH127 K09955 - - 0.0 1140.0
TLS2_k127_5706177_1 Carboxypeptidase regulatory-like domain - - - 3.896e-287 917.0
TLS2_k127_5706177_2 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005118 589.0
TLS2_k127_5706177_3 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 332.0
TLS2_k127_5706177_4 Ferredoxin - - - 0.0000000000000000000000000000000000000001614 155.0
TLS2_k127_5708128_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004561 293.0
TLS2_k127_5708128_1 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000006119 194.0
TLS2_k127_5708128_2 Hypothetical methyltransferase K07755 - 2.1.1.137 0.000000000000000002679 85.0
TLS2_k127_5708572_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000003584 232.0
TLS2_k127_5708572_1 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000006048 210.0
TLS2_k127_5708572_3 Tyrosine phosphatase family - - - 0.000000000000000000000000157 113.0
TLS2_k127_5708572_4 Pyruvate phosphate dikinase - - - 0.0000000000000000000000009006 112.0
TLS2_k127_5719697_0 Tricorn protease homolog - - - 0.0 1326.0
TLS2_k127_5719697_1 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 2.141e-201 635.0
TLS2_k127_5719697_2 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 548.0
TLS2_k127_5719697_3 ATPases associated with a variety of cellular activities K05847 GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0031460,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 302.0
TLS2_k127_5719697_4 GYD domain - - - 0.00000000000000000000000000005604 122.0
TLS2_k127_5719850_0 efflux transmembrane transporter activity - - - 2.557e-249 797.0
TLS2_k127_5719850_1 Hypothetical methyltransferase K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 326.0
TLS2_k127_5719850_2 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 341.0
TLS2_k127_5719850_3 negative regulation of transcription, DNA-templated K10947 - - 0.000000000000000000000000000004424 123.0
TLS2_k127_5719850_5 PFAM regulatory protein ArsR K03892 - - 0.0000000000000000000001034 106.0
TLS2_k127_5719850_6 RES domain - - - 0.00000000000001482 85.0
TLS2_k127_5719850_7 Protein of unknown function (DUF2384) - - - 0.00004968 51.0
TLS2_k127_5719865_0 Phosphoribulokinase / Uridine kinase family K00876 - 2.7.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 472.0
TLS2_k127_5719865_1 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006684 418.0
TLS2_k127_5719865_2 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.0000000000000003788 89.0
TLS2_k127_5719865_3 - - - - 0.000000000002571 73.0
TLS2_k127_5719865_4 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.00001121 57.0
TLS2_k127_5723052_0 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 565.0
TLS2_k127_5723052_1 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000001306 132.0
TLS2_k127_5729510_0 COG0187 Type IIA topoisomerase (DNA gyrase topo II topoisomerase IV) B subunit K02470,K02622 - 5.99.1.3 5.562e-279 871.0
TLS2_k127_5745771_0 Sigma-54 interaction domain K15836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008351 624.0
TLS2_k127_5745771_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 467.0
TLS2_k127_5745771_2 HlyD family secretion protein K03585 - - 0.000000000000000000003122 96.0
TLS2_k127_5745771_3 Preprotein translocase SecG subunit K03075 - - 0.000000000000002885 81.0
TLS2_k127_5745771_4 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000000000005984 72.0
TLS2_k127_5747797_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 576.0
TLS2_k127_5747797_1 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008193 375.0
TLS2_k127_5747797_2 ABC-type dipeptide oligopeptide nickel transport K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 350.0
TLS2_k127_5747797_3 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 348.0
TLS2_k127_5747797_4 Belongs to the ABC transporter superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001135 282.0
TLS2_k127_574789_0 Belongs to the glycosyl hydrolase 67 family K01235 - 3.2.1.139 5.774e-267 841.0
TLS2_k127_574789_1 Glycosyl-hydrolase 97 C-terminal, oligomerisation K01187 - 3.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 538.0
TLS2_k127_574789_2 glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 425.0
TLS2_k127_574789_3 Calcineurin-like phosphoesterase K01028,K07098 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 391.0
TLS2_k127_574789_4 Domain of unknown function (DUF892) - - - 0.00000000000000000000000000000000000000000005578 167.0
TLS2_k127_5748766_0 ATPases associated with a variety of cellular activities K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 428.0
TLS2_k127_5748766_1 COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 359.0
TLS2_k127_5748766_2 xylanase chitin deacetylase - - - 0.00000000000000000000000000000000000001018 159.0
TLS2_k127_5748766_3 Glycosyltransferase like family 2 - - - 0.0000000000000000000000001359 118.0
TLS2_k127_5748766_4 cellulase activity - - - 0.0000000005444 63.0
TLS2_k127_5748766_5 Glycosyl transferase, family 2 - - - 0.0000000103 60.0
TLS2_k127_5754294_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1135.0
TLS2_k127_5754294_1 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000004519 269.0
TLS2_k127_5754294_2 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000000000000000002388 132.0
TLS2_k127_5754294_3 outer membrane autotransporter barrel domain protein - - - 0.000000222 62.0
TLS2_k127_5757641_0 ADP-ribosylglycohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 394.0
TLS2_k127_5757641_1 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 327.0
TLS2_k127_5757641_2 - - - - 0.0000000000000000000000007858 108.0
TLS2_k127_5757641_3 - - - - 0.000000000000000000000002444 106.0
TLS2_k127_5757641_4 PFAM Periplasmic binding protein LacI transcriptional regulator K10439 - - 0.000000000000000000002109 96.0
TLS2_k127_5760062_0 DNA-K related protein - - - 1.388e-222 722.0
TLS2_k127_5760062_1 MreB/Mbl protein - - - 7.813e-222 702.0
TLS2_k127_5760062_10 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004528 377.0
TLS2_k127_5760062_11 Protein involved in outer membrane biogenesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 355.0
TLS2_k127_5760062_12 COG0569 K transport systems NAD-binding component K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 319.0
TLS2_k127_5760062_13 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001432 283.0
TLS2_k127_5760062_14 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001152 285.0
TLS2_k127_5760062_15 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001962 258.0
TLS2_k127_5760062_16 double-stranded DNA 3'-5' exodeoxyribonuclease activity K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000003271 239.0
TLS2_k127_5760062_17 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000001172 234.0
TLS2_k127_5760062_18 Protein of unknown function (DUF3014) - - - 0.00000000000000000000000000000000000000000001679 173.0
TLS2_k127_5760062_19 DNA-templated transcription, initiation K02405 - - 0.00000000000000000000000000000000000000000108 167.0
TLS2_k127_5760062_2 Insulinase (Peptidase family M16) K07263 - - 7.345e-195 651.0
TLS2_k127_5760062_21 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000771 165.0
TLS2_k127_5760062_22 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000007319 153.0
TLS2_k127_5760062_23 Tellurite resistance protein TerB - - - 0.0000000000000000000000000000000000001541 148.0
TLS2_k127_5760062_24 DoxX K15977 - - 0.000000000000000000000000000000000001418 142.0
TLS2_k127_5760062_25 Domain of unknown function (DUF2760) - - - 0.0000000000000000000000000000000001271 139.0
TLS2_k127_5760062_26 Transcription factor zinc-finger - - - 0.000000000000000000000000001014 121.0
TLS2_k127_5760062_27 - - - - 0.000000000000000000009688 108.0
TLS2_k127_5760062_28 Putative prokaryotic signal transducing protein - - - 0.000003062 52.0
TLS2_k127_5760062_29 transglycosylase K08309 - - 0.0001546 53.0
TLS2_k127_5760062_3 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004809 598.0
TLS2_k127_5760062_4 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 518.0
TLS2_k127_5760062_5 amino acid carrier protein K03310 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005183 481.0
TLS2_k127_5760062_6 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 429.0
TLS2_k127_5760062_7 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006687 422.0
TLS2_k127_5760062_8 involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein K08282 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 433.0
TLS2_k127_5760062_9 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 400.0
TLS2_k127_5769084_0 PFAM NADH Ubiquinone plastoquinone (complex I) K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000502 383.0
TLS2_k127_5769084_1 Domain of unknown function (DUF4040) K05559,K05565 - - 0.00000000000000000000000000000000000000000000555 168.0
TLS2_k127_5769084_2 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.000000000000000000000000001509 115.0
TLS2_k127_5769084_3 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.0000000000000000000000002858 116.0
TLS2_k127_5770037_0 MacB-like periplasmic core domain - - - 4.08e-291 924.0
TLS2_k127_5770037_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 8.863e-277 885.0
TLS2_k127_5770037_10 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006055 505.0
TLS2_k127_5770037_11 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000695 448.0
TLS2_k127_5770037_12 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 457.0
TLS2_k127_5770037_13 Iron-containing alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 402.0
TLS2_k127_5770037_14 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 417.0
TLS2_k127_5770037_15 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 328.0
TLS2_k127_5770037_16 PFAM phosphoesterase, RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 304.0
TLS2_k127_5770037_17 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007113 309.0
TLS2_k127_5770037_18 Alcohol dehydrogenase GroES-like domain K13979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000214 310.0
TLS2_k127_5770037_19 Phosphomannose isomerase type I K01809 - 5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000135 261.0
TLS2_k127_5770037_2 Bacterial alpha-L-rhamnosidase C-terminal domain K05989 - 3.2.1.40 9.525e-248 803.0
TLS2_k127_5770037_20 Glucose inhibited division protein A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000762 253.0
TLS2_k127_5770037_21 Belongs to the MlaE permease family K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003004 246.0
TLS2_k127_5770037_22 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000003579 240.0
TLS2_k127_5770037_23 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000005422 243.0
TLS2_k127_5770037_24 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000007563 226.0
TLS2_k127_5770037_25 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.00000000000000000000000000000000000000000000000000000009835 225.0
TLS2_k127_5770037_26 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000000000000000002679 192.0
TLS2_k127_5770037_27 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000001614 189.0
TLS2_k127_5770037_28 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.0000000000000000000000000000000000000000001277 185.0
TLS2_k127_5770037_29 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000001564 164.0
TLS2_k127_5770037_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 2.812e-222 729.0
TLS2_k127_5770037_30 DoxX K15977 - - 0.00000000000000000000000000000001665 134.0
TLS2_k127_5770037_31 transcriptional regulator PadR family - - - 0.00000000000000000000000000000005312 127.0
TLS2_k127_5770037_32 PFAM von Willebrand factor type A - - - 0.0000000000000000000000000000002384 137.0
TLS2_k127_5770037_33 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000000000000000000000001475 130.0
TLS2_k127_5770037_34 Antibiotic biosynthesis monooxygenase K11530 - 5.3.1.32 0.00000000000000000000000005533 121.0
TLS2_k127_5770037_35 unsaturated fatty acid biosynthetic process K00508 GO:0001676,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016053,GO:0016213,GO:0016215,GO:0016491,GO:0016705,GO:0016717,GO:0019752,GO:0032787,GO:0042759,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:0072330,GO:1901576 1.14.19.3 0.0000000000000000000000002814 118.0
TLS2_k127_5770037_37 virulence factor Mce family protein K02067 - - 0.00000000000000000002323 103.0
TLS2_k127_5770037_38 peptidyl-tyrosine sulfation - - - 0.0000000002422 68.0
TLS2_k127_5770037_39 Trypsin K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 0.00001243 57.0
TLS2_k127_5770037_4 Acetyl-coenzyme A transporter 1 K08218 - - 5.903e-201 640.0
TLS2_k127_5770037_40 YtxH-like protein - - - 0.00004106 56.0
TLS2_k127_5770037_41 Patatin phospholipase K07001 - - 0.0005222 52.0
TLS2_k127_5770037_5 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.412e-200 651.0
TLS2_k127_5770037_6 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006608 595.0
TLS2_k127_5770037_7 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 541.0
TLS2_k127_5770037_8 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 513.0
TLS2_k127_5770037_9 AAA ATPase, central domain protein K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 514.0
TLS2_k127_5770734_0 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 602.0
TLS2_k127_5770734_1 PFAM Major Facilitator Superfamily K08191 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008469 518.0
TLS2_k127_5770734_2 C-terminus of AA_permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 504.0
TLS2_k127_5770734_3 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 391.0
TLS2_k127_5770734_4 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 348.0
TLS2_k127_5770734_5 enoyl-coa hydratase carnithine racemase K15513 - 4.1.2.44 0.0000000000000000000000000000000000000000000000000058 182.0
TLS2_k127_5770734_6 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity K13991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464 - 0.0000000000484 72.0
TLS2_k127_5770734_7 Domain of unknown function (DUF2382) - - - 0.00000001822 64.0
TLS2_k127_5799191_0 PFAM Cys Met metabolism pyridoxal-phosphate- dependent protein K01740,K10764 - 2.5.1.49 1.463e-199 642.0
TLS2_k127_5799191_1 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 523.0
TLS2_k127_5799191_10 hydroperoxide reductase activity - - - 0.000000000000000000004381 100.0
TLS2_k127_5799191_11 - - - - 0.0000003198 57.0
TLS2_k127_5799191_2 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006673 372.0
TLS2_k127_5799191_3 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 370.0
TLS2_k127_5799191_4 Trehalose utilisation - - - 0.000000000000000000000000000000000000000000000000000000000000000001404 237.0
TLS2_k127_5799191_5 domain protein K06929 - - 0.0000000000000000000000000000000000000000000008771 189.0
TLS2_k127_5799191_6 TRAP transporter solute receptor, TAXI family K07080 - - 0.0000000000000000000000000000000000000000002952 172.0
TLS2_k127_5799191_7 Membrane-bound dehydrogenase domain protein - - - 0.000000000000000000000000000000000000002141 154.0
TLS2_k127_5799191_8 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000002286 158.0
TLS2_k127_5799191_9 hydroperoxide reductase activity - - - 0.00000000000000000000000000000001432 129.0
TLS2_k127_580649_0 Dienelactone hydrolase family - - - 7.147e-307 954.0
TLS2_k127_580649_1 CoA enzyme activase uncharacterised domain (DUF2229) - - - 2.043e-285 888.0
TLS2_k127_580649_2 4 iron, 4 sulfur cluster binding - - - 4.449e-199 639.0
TLS2_k127_580649_3 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 623.0
TLS2_k127_580649_4 asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 441.0
TLS2_k127_580649_5 Peptidase family M23 K21472 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002954 295.0
TLS2_k127_580649_6 cyclic nucleotide-binding - - - 0.000000000000000000000000000000000000000000000000000000000000007205 230.0
TLS2_k127_581630_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1282.0
TLS2_k127_581630_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 1.671e-235 735.0
TLS2_k127_581630_10 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.0000000000000000000000000000000000000000000000000000000000002116 214.0
TLS2_k127_581630_11 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000000000000000000000006775 226.0
TLS2_k127_581630_12 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000002806 217.0
TLS2_k127_581630_13 Aminoacyl-tRNA editing domain K19055 - - 0.00000000000000000000000000000000000000001225 168.0
TLS2_k127_581630_2 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 1.698e-203 643.0
TLS2_k127_581630_3 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 2.687e-194 617.0
TLS2_k127_581630_4 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 531.0
TLS2_k127_581630_5 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 495.0
TLS2_k127_581630_6 ABC transporter transmembrane region K16013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 457.0
TLS2_k127_581630_7 TIGRFAM ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC K06148,K16012,K16014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006655 396.0
TLS2_k127_581630_8 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004164 350.0
TLS2_k127_581630_9 DNA recombination-mediator protein A K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004411 278.0
TLS2_k127_5818278_0 PFAM Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 419.0
TLS2_k127_5818278_1 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000002409 120.0
TLS2_k127_5822869_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 2.209e-213 679.0
TLS2_k127_5832089_0 Urocanase C-terminal domain K01712 - 4.2.1.49 2.895e-256 801.0
TLS2_k127_5832089_1 Histidine ammonia-lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 484.0
TLS2_k127_5832089_10 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001959 268.0
TLS2_k127_5832089_11 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000005464 224.0
TLS2_k127_5832089_12 Stage II sporulation protein E K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000007312 224.0
TLS2_k127_5832089_13 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000007929 197.0
TLS2_k127_5832089_14 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000379 203.0
TLS2_k127_5832089_15 membrane - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000982 173.0
TLS2_k127_5832089_16 - - - - 0.000000000000000000000000000000000001571 141.0
TLS2_k127_5832089_17 - - - - 0.000000000000000000000000000001431 136.0
TLS2_k127_5832089_18 protein involved in tolerance to divalent cations K03926 - - 0.00000000000000000000000002467 111.0
TLS2_k127_5832089_19 Domain of unknown function (DUF202) K00389 - - 0.00000000000000000000013 102.0
TLS2_k127_5832089_2 Cys/Met metabolism PLP-dependent enzyme K01760,K17217 - 4.4.1.1,4.4.1.2,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006876 471.0
TLS2_k127_5832089_21 PFAM AsmA family protein K07289 - - 0.0000000000002998 83.0
TLS2_k127_5832089_23 BON domain K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.00000000001625 78.0
TLS2_k127_5832089_24 AAA ATPase domain - - - 0.0000000004486 72.0
TLS2_k127_5832089_25 periplasmic or secreted lipoprotein K04065 - - 0.00004776 57.0
TLS2_k127_5832089_26 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589,K13052 - - 0.0000917 51.0
TLS2_k127_5832089_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005108 462.0
TLS2_k127_5832089_4 mevalonate kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 358.0
TLS2_k127_5832089_5 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 333.0
TLS2_k127_5832089_6 TonB-dependent Receptor Plug K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 346.0
TLS2_k127_5832089_7 SPFH domain-Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 329.0
TLS2_k127_5832089_8 ABC transporter K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 289.0
TLS2_k127_5832089_9 Membrane-bound serine protease (ClpP class) K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001064 278.0
TLS2_k127_5836078_0 Domain of unknown function (DUF4445) - - - 2.298e-241 759.0
TLS2_k127_5836078_1 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 1.569e-204 642.0
TLS2_k127_5836078_2 methionine synthase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006237 457.0
TLS2_k127_5836078_3 Homocysteine S-methyltransferase K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 449.0
TLS2_k127_5836078_4 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005321 361.0
TLS2_k127_5836078_5 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 361.0
TLS2_k127_5836078_6 cobalamin binding - - - 0.00000000000000000000000000003765 121.0
TLS2_k127_5836162_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 2.519e-294 933.0
TLS2_k127_5836162_1 iron-sulfur cluster assembly K07033,K09014 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - 3.375e-267 827.0
TLS2_k127_5836162_10 TIGRFAM SUF system FeS K04488 - - 0.00000000000000000000000000000000000000000000000000000001985 201.0
TLS2_k127_5836162_11 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K01838 - 5.4.2.6 0.00000000000000000000000000000000000000000000000001983 186.0
TLS2_k127_5836162_12 - - - - 0.000000000000000000000000000000000000001188 154.0
TLS2_k127_5836162_13 PaaD-like protein - - - 0.00000000000000000000000000000000003079 138.0
TLS2_k127_5836162_14 Transcriptional regulator - - - 0.00000000000000000000000000001598 125.0
TLS2_k127_5836162_15 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000634 108.0
TLS2_k127_5836162_16 - - - - 0.0000000000000000000005153 103.0
TLS2_k127_5836162_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008083 553.0
TLS2_k127_5836162_3 PhoPQ-activated pathogenicity-related protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007408 507.0
TLS2_k127_5836162_4 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 488.0
TLS2_k127_5836162_5 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 440.0
TLS2_k127_5836162_6 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000092 380.0
TLS2_k127_5836162_7 ABC transporter K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 372.0
TLS2_k127_5836162_8 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 373.0
TLS2_k127_5836162_9 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 305.0
TLS2_k127_5884302_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 392.0
TLS2_k127_5884302_1 myo-inosose-2 dehydratase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007979 304.0
TLS2_k127_5884302_2 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000001468 221.0
TLS2_k127_5887570_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.112e-288 928.0
TLS2_k127_5887570_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.123e-233 732.0
TLS2_k127_5887570_10 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000000000000006171 98.0
TLS2_k127_5887570_11 PFAM 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) - - - 0.000000000004853 76.0
TLS2_k127_5887570_12 fumarate reductase K00239 - 1.3.5.1,1.3.5.4 0.000001447 61.0
TLS2_k127_5887570_2 ATPases associated with a variety of cellular activities K01990,K09689,K09691,K09693 - 3.6.3.38,3.6.3.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 447.0
TLS2_k127_5887570_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001969 281.0
TLS2_k127_5887570_4 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003338 269.0
TLS2_k127_5887570_5 ABC-2 type transporter K09690 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008671 264.0
TLS2_k127_5887570_6 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.000000000000000000000000000000000000000000000009933 177.0
TLS2_k127_5887570_7 Transcription termination factor nusG - - - 0.000000000000000000000000000000000006665 142.0
TLS2_k127_5887570_8 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000007849 158.0
TLS2_k127_5887570_9 Peptidylprolyl isomerase K03771 - 5.2.1.8 0.000000000000000000000000000000002297 143.0
TLS2_k127_5900821_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 1.048e-194 616.0
TLS2_k127_5900821_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 415.0
TLS2_k127_5900821_2 Metallopeptidase family M24 K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 320.0
TLS2_k127_5900821_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003133 280.0
TLS2_k127_5900821_4 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000003008 207.0
TLS2_k127_5900821_5 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000006318 192.0
TLS2_k127_5900821_6 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000001285 182.0
TLS2_k127_5900821_7 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.00000000000000007795 81.0
TLS2_k127_5900821_8 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000001357 68.0
TLS2_k127_5900821_9 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000001832 56.0
TLS2_k127_5903903_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 4.975e-258 821.0
TLS2_k127_5903903_1 phosphatidylcholine synthase activity K01004,K17103 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576 2.7.8.24,2.7.8.8 0.0000000000000000000000000000000000000000000000000002004 195.0
TLS2_k127_5903903_2 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000003162 206.0
TLS2_k127_5903903_3 - - - - 0.00002838 53.0
TLS2_k127_5914688_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 562.0
TLS2_k127_5914688_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 423.0
TLS2_k127_5914688_2 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000004719 244.0
TLS2_k127_5914688_3 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000245 243.0
TLS2_k127_5914688_4 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000003608 132.0
TLS2_k127_5914688_5 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000006931 63.0
TLS2_k127_5954712_0 choline dehydrogenase activity K03333 - 1.1.3.6 0.0 1375.0
TLS2_k127_5954712_1 PFAM FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 560.0
TLS2_k127_5954712_2 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 491.0
TLS2_k127_5954712_3 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 304.0
TLS2_k127_5954712_4 Spore coat protein CotH - - - 0.000000000000000000000000000000000000000000000000000000000000009116 234.0
TLS2_k127_5954712_5 Domain of unknown function (DUF4956) - - - 0.0000000000000000004407 97.0
TLS2_k127_5954712_6 phosphate-selective porin O and P K07221 - - 0.000000000000000003622 97.0
TLS2_k127_5977940_0 Transglycosylase SLT domain K08309 - - 0.000000000000000000000000000000000000000000000000000000000000007317 244.0
TLS2_k127_5977940_1 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000001987 115.0
TLS2_k127_5977940_2 nuclear chromosome segregation - - - 0.000000004061 68.0
TLS2_k127_5981596_0 xaa-pro aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003991 566.0
TLS2_k127_5981596_1 chaperone-mediated protein folding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009389 472.0
TLS2_k127_5981596_2 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 402.0
TLS2_k127_5981596_3 SIS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 332.0
TLS2_k127_5981596_4 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000212 252.0
TLS2_k127_5981596_5 BlaR1 peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002409 264.0
TLS2_k127_5981596_6 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000473 267.0
TLS2_k127_5981596_7 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000007843 221.0
TLS2_k127_5981596_8 Penicillinase repressor - - - 0.000000000000000000000000000000000000000641 151.0
TLS2_k127_5985721_0 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 466.0
TLS2_k127_5985721_1 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004537 259.0
TLS2_k127_5985721_2 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000001568 244.0
TLS2_k127_5985721_3 Protein of unknown function (DUF2400) K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000075 241.0
TLS2_k127_5985721_4 - - - - 0.000000000000000000000000000000000000000000000000001149 189.0
TLS2_k127_5985721_5 - - - - 0.00000004378 56.0
TLS2_k127_5990249_0 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 539.0
TLS2_k127_5990249_1 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 449.0
TLS2_k127_5990249_2 Dehydrogenase K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007955 288.0
TLS2_k127_5990249_3 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000004868 233.0
TLS2_k127_5990249_4 glycerol channel activity K09876,K09877,K09886,K10404 GO:0002376,GO:0003674,GO:0005215,GO:0005372,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006833,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008643,GO:0009605,GO:0009607,GO:0009617,GO:0015250,GO:0015267,GO:0015318,GO:0015791,GO:0015793,GO:0015850,GO:0016020,GO:0016323,GO:0022803,GO:0022838,GO:0022857,GO:0042044,GO:0042742,GO:0043207,GO:0044425,GO:0044459,GO:0044464,GO:0045087,GO:0050829,GO:0050896,GO:0051179,GO:0051234,GO:0051704,GO:0051707,GO:0055085,GO:0071702,GO:0071944,GO:0098542,GO:0098590 - 0.00000000000000000000000000000000000000000000000000006899 192.0
TLS2_k127_5990249_5 oxidoreductase activity - - - 0.0000000000000000000000000000002262 144.0
TLS2_k127_5990249_6 Tetratricopeptide repeat K12132 - 2.7.11.1 0.000000000000000000000004086 105.0
TLS2_k127_5990249_7 Copper resistance protein CopZ K07213 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000002791 71.0
TLS2_k127_5992252_0 Carboxypeptidase regulatory-like domain - - - 2.932e-198 644.0
TLS2_k127_5992252_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 456.0
TLS2_k127_5992252_10 Diacylglycerol kinase catalytic domain (presumed) - - - 0.00000000000000000000000000000000000000000000000001342 191.0
TLS2_k127_5992252_11 Protein of unknown function DUF47 K02039,K07220 GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000007914 168.0
TLS2_k127_5992252_12 Phosphohistidine phosphatase, SixA K08296 - - 0.000000000000000000000001162 119.0
TLS2_k127_5992252_13 PFAM CHAD domain containing protein - - - 0.000000006035 70.0
TLS2_k127_5992252_2 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 395.0
TLS2_k127_5992252_3 TIGRFAM phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 383.0
TLS2_k127_5992252_4 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006143 366.0
TLS2_k127_5992252_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003033 349.0
TLS2_k127_5992252_6 Binding-protein-dependent transport system inner membrane component K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002727 324.0
TLS2_k127_5992252_7 dTDP biosynthetic process K00560,K00943,K01585 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.1.1.45,2.7.4.9,4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000002215 276.0
TLS2_k127_5992252_8 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000002135 238.0
TLS2_k127_5992252_9 PFAM response regulator receiver K02483,K07658,K07668 - - 0.0000000000000000000000000000000000000000000000000000002427 203.0
TLS2_k127_5993675_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007963 389.0
TLS2_k127_5993675_1 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 322.0
TLS2_k127_5993675_2 Pyridoxamine 5'-phosphate oxidase K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000004321 207.0
TLS2_k127_5993675_3 Phosphoribulokinase / Uridine kinase family K00876 - 2.7.1.48 0.0000000000000000000000000000002026 131.0
TLS2_k127_6006675_0 PFAM AAA ATPase central domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 356.0
TLS2_k127_6006675_1 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879,K09457 - 1.7.1.13 0.00000000000000000000000000000000008694 134.0
TLS2_k127_6006675_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000001567 119.0
TLS2_k127_6006675_3 Smr domain - - - 0.0000000000000000000000005566 108.0
TLS2_k127_6014615_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003295 381.0
TLS2_k127_6014615_1 Transposase K07483 - - 0.0000000000000000000000000000000000000000000000004057 180.0
TLS2_k127_6014615_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000001122 174.0
TLS2_k127_6014615_3 IS66 Orf2 like protein K07484 - - 0.000000000000000000000000000000000000000000007368 165.0
TLS2_k127_6014615_4 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000001659 124.0
TLS2_k127_601664_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13924 - 2.1.1.80,3.1.1.61 6.651e-224 734.0
TLS2_k127_601664_1 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000103 234.0
TLS2_k127_6023640_0 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 564.0
TLS2_k127_6023640_1 SPFH domain-Band 7 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 541.0
TLS2_k127_6023640_10 Lipid A biosynthesis K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000004039 202.0
TLS2_k127_6023640_11 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000008012 187.0
TLS2_k127_6023640_12 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000004351 182.0
TLS2_k127_6023640_13 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000001156 109.0
TLS2_k127_6023640_14 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.00000002875 66.0
TLS2_k127_6023640_2 TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type I K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 471.0
TLS2_k127_6023640_3 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007104 460.0
TLS2_k127_6023640_4 tRNA wobble cytosine modification - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 446.0
TLS2_k127_6023640_5 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 345.0
TLS2_k127_6023640_6 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 308.0
TLS2_k127_6023640_7 Peptidoglycan-binding domain 1 protein K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005514 283.0
TLS2_k127_6023640_8 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000003203 265.0
TLS2_k127_6023640_9 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000001584 231.0
TLS2_k127_6030384_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 320.0
TLS2_k127_6030384_1 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000005155 185.0
TLS2_k127_6030384_2 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000003829 168.0
TLS2_k127_6030384_3 Transcriptional regulator K07979 - - 0.0000000000000000000000000000001044 127.0
TLS2_k127_6035305_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.734e-217 682.0
TLS2_k127_6035305_1 RecQ zinc-binding K03654 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003674 569.0
TLS2_k127_6035305_10 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 292.0
TLS2_k127_6035305_11 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006515 289.0
TLS2_k127_6035305_12 Transcriptional regulator, LysR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009123 279.0
TLS2_k127_6035305_13 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000001553 259.0
TLS2_k127_6035305_14 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000002363 248.0
TLS2_k127_6035305_15 Disulphide isomerase - - - 0.000000000000000000000000000000000000000000000000000001044 196.0
TLS2_k127_6035305_16 Two component signalling adaptor domain K03408 - - 0.0000000000000000000000000000000000000000000000000001047 191.0
TLS2_k127_6035305_17 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.0000000000000000000000000000000000004228 162.0
TLS2_k127_6035305_18 GGDEF domain K03413 - - 0.000000000000000000000000004076 116.0
TLS2_k127_6035305_2 Deoxyribodipyrimidine photo-lyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 555.0
TLS2_k127_6035305_3 Signal transducing histidine kinase, homodimeric domain K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007689 496.0
TLS2_k127_6035305_4 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 467.0
TLS2_k127_6035305_5 Radical SAM superfamily K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 421.0
TLS2_k127_6035305_6 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 400.0
TLS2_k127_6035305_7 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 383.0
TLS2_k127_6035305_8 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000836 375.0
TLS2_k127_6035305_9 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 344.0
TLS2_k127_6047354_0 pyrroloquinoline quinone binding - - - 3.147e-232 744.0
TLS2_k127_6047354_1 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 611.0
TLS2_k127_6047354_2 beta-galactosidase activity - - - 0.0000002632 52.0
TLS2_k127_6053676_0 Carboxylesterase family - - - 0.000000000000000000000000000000000000001454 164.0
TLS2_k127_6053676_1 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008757,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0010340,GO:0016053,GO:0016740,GO:0016741,GO:0016787,GO:0016788,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032259,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197 0.0000000002174 72.0
TLS2_k127_6088983_0 transcription factor binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 514.0
TLS2_k127_6088983_1 PFAM Lipid A - - - 0.00000000000000000000000000003141 124.0
TLS2_k127_6088983_2 PFAM Phosphate-selective porin O K07221 - - 0.0000000000000000000005859 103.0
TLS2_k127_6088983_3 Rieske [2Fe-2S] domain K02636 - 1.10.9.1 0.000000000002494 76.0
TLS2_k127_6088983_4 YceI-like domain - - - 0.00000000027 70.0
TLS2_k127_6088983_5 - - - - 0.00000000119 71.0
TLS2_k127_6102794_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009405,GO:0009605,GO:0009607,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0035821,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043207,GO:0043492,GO:0043952,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0075136,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006555 317.0
TLS2_k127_6102794_1 CoA-transferase family III K07749 - 2.8.3.16 0.000000000008388 69.0
TLS2_k127_6138701_0 4 iron, 4 sulfur cluster binding K03737 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008955 465.0
TLS2_k127_6138701_1 Part of a membrane complex involved in electron transport K03615 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005386 423.0
TLS2_k127_6138701_2 Part of a membrane complex involved in electron transport K03614 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 322.0
TLS2_k127_6153915_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 607.0
TLS2_k127_6153915_1 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000312 151.0
TLS2_k127_6153915_2 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000003878 131.0
TLS2_k127_6162058_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 625.0
TLS2_k127_6162058_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006159 535.0
TLS2_k127_6162058_10 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.000000000000000000000000000000000000000000000000000000000001974 218.0
TLS2_k127_6162058_11 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.00000000000000000000000002035 128.0
TLS2_k127_6162058_12 - - - - 0.00000000000000000000199 106.0
TLS2_k127_6162058_13 mttA/Hcf106 family K03116 - - 0.000000000000001092 81.0
TLS2_k127_6162058_2 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 444.0
TLS2_k127_6162058_3 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 452.0
TLS2_k127_6162058_4 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007456 411.0
TLS2_k127_6162058_5 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 377.0
TLS2_k127_6162058_6 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 361.0
TLS2_k127_6162058_7 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000166 292.0
TLS2_k127_6162058_8 Peptidase M48 K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005585 286.0
TLS2_k127_6162058_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000000000000008242 222.0
TLS2_k127_616348_0 Nickel-dependent hydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 617.0
TLS2_k127_616348_1 Belongs to the HypD family K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009192 570.0
TLS2_k127_616348_10 Part of a membrane complex involved in electron transport K03617 - - 0.000000000000000000000000000000000000000000000000000000000000000000001913 243.0
TLS2_k127_616348_11 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000003321 173.0
TLS2_k127_616348_12 PFAM Formylglycine-generating sulfatase enzyme K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000008168 174.0
TLS2_k127_616348_13 Hydrogenase/urease nickel incorporation, metallochaperone, hypA K04651 - - 0.000000000000000000000000000000000008237 146.0
TLS2_k127_616348_14 Hydrogenase maturation protease K03605 - - 0.00000000000000000000000000000000003648 144.0
TLS2_k127_616348_15 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.00000000000000000000000000000001979 133.0
TLS2_k127_616348_16 HupF/HypC family K04653 - - 0.00000000000000000000002502 112.0
TLS2_k127_616348_17 oxidoreductase activity, acting on diphenols and related substances as donors K02636 - 1.10.9.1 0.00000000000000000049 95.0
TLS2_k127_616348_2 CobW/HypB/UreG, nucleotide-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 556.0
TLS2_k127_616348_3 TIGRFAM ornithine aminotransferase K00819 - 2.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 566.0
TLS2_k127_616348_4 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005985 516.0
TLS2_k127_616348_5 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 402.0
TLS2_k127_616348_6 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 348.0
TLS2_k127_616348_7 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007663 348.0
TLS2_k127_616348_8 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065,K13252 - 2.1.3.3,2.1.3.6,2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 337.0
TLS2_k127_616348_9 Amino acid kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 321.0
TLS2_k127_61817_0 MacB-like periplasmic core domain - - - 9.757e-271 859.0
TLS2_k127_61817_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 3.934e-222 707.0
TLS2_k127_61817_10 Lysin motif - - - 0.0000000000000000000000000000002045 129.0
TLS2_k127_61817_11 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000002201 128.0
TLS2_k127_61817_13 Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000002632 118.0
TLS2_k127_61817_14 SnoaL-like domain - - - 0.0000000000000000000002648 106.0
TLS2_k127_61817_15 Protein of unknown function, DUF485 - - - 0.000000000000000000006961 97.0
TLS2_k127_61817_16 - - - - 0.00000000000000000001823 100.0
TLS2_k127_61817_17 FtsX-like permease family - - - 0.0000001002 54.0
TLS2_k127_61817_18 Domain of unknown function (DUF4115) - - - 0.00001771 57.0
TLS2_k127_61817_2 Glycosyl hydrolases family 43 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 546.0
TLS2_k127_61817_20 DivIVA protein K04074 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0008648 52.0
TLS2_k127_61817_3 FtsX-like permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 545.0
TLS2_k127_61817_4 ABC-type multidrug transport system ATPase and permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 439.0
TLS2_k127_61817_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007821 320.0
TLS2_k127_61817_6 BlaR1 peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 312.0
TLS2_k127_61817_7 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002319 281.0
TLS2_k127_61817_8 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000000000004018 160.0
TLS2_k127_61817_9 Penicillinase repressor - - - 0.0000000000000000000000000000000000004809 146.0
TLS2_k127_6210084_0 Oligoendopeptidase f - - - 1.621e-254 803.0
TLS2_k127_6210084_1 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009312 494.0
TLS2_k127_6210084_2 TonB-dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003592 334.0
TLS2_k127_6210084_3 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 294.0
TLS2_k127_6210084_4 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005583 306.0
TLS2_k127_6216781_0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 0.0 1034.0
TLS2_k127_6216781_1 Aminotransferase K14267,K14287 - 2.6.1.17,2.6.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 464.0
TLS2_k127_6216781_2 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000006028 133.0
TLS2_k127_6216781_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000001244 119.0
TLS2_k127_6216781_4 His Kinase A (phosphoacceptor) domain - - - 0.00000009917 65.0
TLS2_k127_6216781_5 Histidine - - - 0.000526 53.0
TLS2_k127_6235486_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.017e-245 777.0
TLS2_k127_6235486_1 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 583.0
TLS2_k127_6235486_2 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 448.0
TLS2_k127_6235486_3 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006848 367.0
TLS2_k127_6235486_4 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000002858 247.0
TLS2_k127_6235486_5 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000776 188.0
TLS2_k127_6235486_6 Putative regulatory protein - - - 0.00000000000000000004006 94.0
TLS2_k127_6237220_0 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 417.0
TLS2_k127_6237220_1 Udp N-acetylglucosamine O-acyltransferase; Domain 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 307.0
TLS2_k127_6237220_2 Protein of unknown function (DUF1009) K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003173 294.0
TLS2_k127_6237220_3 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004584 293.0
TLS2_k127_6237220_4 Surface antigen K07277 GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000508 283.0
TLS2_k127_6237220_5 Amidohydrolase family K20810 - 3.5.4.40 0.00000000000000000000000000000000000000000000000000000000000000002562 240.0
TLS2_k127_6237220_6 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K07081,K11782,K11784 - 1.21.98.1,4.2.1.151 0.000000000000000000000000000000000000000000001287 181.0
TLS2_k127_6237220_7 Elongator protein 3, MiaB family, Radical SAM K18285 - 2.5.1.120 0.000000000000005477 87.0
TLS2_k127_6237220_8 unfolded protein binding K06142 - - 0.000000000004264 76.0
TLS2_k127_6241081_0 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 4.077e-252 799.0
TLS2_k127_6241081_1 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 392.0
TLS2_k127_6241081_2 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 315.0
TLS2_k127_6241081_3 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 329.0
TLS2_k127_6241081_4 Orotidine 5'-phosphate decarboxylase / HUMPS family K08093 - 4.1.2.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004154 303.0
TLS2_k127_6241081_5 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 297.0
TLS2_k127_6241081_6 Maltogenic Amylase, C-terminal domain K05343 - 3.2.1.1,5.4.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001749 292.0
TLS2_k127_6241081_7 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000007989 214.0
TLS2_k127_626299_0 DinB family - - - 0.000000000000000000001751 97.0
TLS2_k127_626299_1 oxidoreductase activity - - - 0.0001961 53.0
TLS2_k127_6273275_0 cell shape determining protein MreB K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 539.0
TLS2_k127_6273275_1 Ribonuclease E/G family K08300,K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 514.0
TLS2_k127_6273275_2 Penicillin-binding protein, dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 429.0
TLS2_k127_6273275_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001801 286.0
TLS2_k127_6273275_4 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000002654 189.0
TLS2_k127_6273275_5 rod shape-determining protein MreC K03570 - - 0.0000000000000000000000000000000008849 149.0
TLS2_k127_6273275_6 shape-determining protein MreD K03571 - - 0.000001043 60.0
TLS2_k127_632464_0 ABC transporter K15738 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - 1.139e-267 837.0
TLS2_k127_632464_1 Belongs to the peptidase S1B family - - - 1.68e-208 668.0
TLS2_k127_632464_2 COG0471 Di- and tricarboxylate transporters K03319,K09477,K11106,K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 604.0
TLS2_k127_632464_3 Putative collagen-binding domain of a collagenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 596.0
TLS2_k127_632464_4 Glycosyl hydrolase family 20, domain 2 K12373 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 535.0
TLS2_k127_632464_5 beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 412.0
TLS2_k127_632464_6 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 377.0
TLS2_k127_632464_7 Haem-degrading - - - 0.0000000000000000000000000000000000000001293 160.0
TLS2_k127_632464_8 SMART metal-dependent phosphohydrolase HD region - - - 0.000008581 51.0
TLS2_k127_632464_9 aminopeptidase N - - - 0.0001568 53.0
TLS2_k127_6346083_0 alpha beta - - - 2.793e-260 845.0
TLS2_k127_6346083_1 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 4.645e-228 716.0
TLS2_k127_6346083_10 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.000287 53.0
TLS2_k127_6346083_2 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 421.0
TLS2_k127_6346083_3 dehydrogenases and related proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 388.0
TLS2_k127_6346083_4 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002007 276.0
TLS2_k127_6346083_5 glycerophosphodiester phosphodiesterase activity K01126 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008081,GO:0008889,GO:0009279,GO:0016020,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044462,GO:0044464,GO:0046872,GO:0071944 3.1.4.46 0.000000000000000000000000000000000000000000000000000000006227 213.0
TLS2_k127_6346083_6 MafB19-like deaminase - - - 0.00000000000000000000002059 108.0
TLS2_k127_6346083_7 Transcriptional regulator PadR-like family - - - 0.00000000000000000000004515 103.0
TLS2_k127_6346083_8 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.0000000000000000000001132 107.0
TLS2_k127_6346083_9 pfam rdd - - - 0.0000004561 61.0
TLS2_k127_6354732_0 Beta-L-arabinofuranosidase, GH127 - - - 2.169e-226 721.0
TLS2_k127_6354732_1 FAD dependent oxidoreductase - - - 4.861e-221 698.0
TLS2_k127_6354732_2 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001436 292.0
TLS2_k127_6354732_3 NIPSNAP family containing protein - - - 0.0000000000000000000000000000000003122 137.0
TLS2_k127_6354732_4 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000837 132.0
TLS2_k127_6354732_5 - - - - 0.00000000000000000000000008751 115.0
TLS2_k127_6354732_6 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K11928 - - 0.00000000000000000004927 93.0
TLS2_k127_6364101_0 Transposase DDE domain group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 482.0
TLS2_k127_63917_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008324 584.0
TLS2_k127_63917_1 - - - - 0.00000000000000000002164 95.0
TLS2_k127_639241_0 Cytochrome c-type biogenesis protein K02198 - - 3.436e-246 786.0
TLS2_k127_639241_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 393.0
TLS2_k127_639241_10 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000001417 104.0
TLS2_k127_639241_11 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000001124 89.0
TLS2_k127_639241_13 - - - - 0.00000001561 65.0
TLS2_k127_639241_2 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000001542 222.0
TLS2_k127_639241_3 Cytochrome C assembly protein K02195 - - 0.000000000000000000000000000000000000000000000000000000000005648 214.0
TLS2_k127_639241_4 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.0000000000000000000000000000000000000000000000000000002145 209.0
TLS2_k127_639241_5 ABC transporter K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000006312 174.0
TLS2_k127_639241_6 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000001375 179.0
TLS2_k127_639241_7 PFAM inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000001398 172.0
TLS2_k127_639241_8 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.00000000000000000000000000003179 121.0
TLS2_k127_639241_9 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000004479 113.0
TLS2_k127_640187_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 380.0
TLS2_k127_640187_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000131 277.0
TLS2_k127_640187_2 Belongs to the ClpA ClpB family K03696 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005978 257.0
TLS2_k127_640187_3 Polysaccharide biosynthesis protein K15856 - 1.1.1.281 0.0000000000000000000000000000000000000000000000000000000000000003143 233.0
TLS2_k127_640209_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 499.0
TLS2_k127_640209_1 Major facilitator K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 488.0
TLS2_k127_640209_10 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000003746 241.0
TLS2_k127_640209_11 - K06921 - - 0.000000000000000000000000000000000000000000000000000000000000003155 236.0
TLS2_k127_640209_12 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000006481 219.0
TLS2_k127_640209_13 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000003179 222.0
TLS2_k127_640209_14 PFAM Penicillinase repressor - - - 0.000000000000000000000000000000000000000006413 158.0
TLS2_k127_640209_15 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000003065 142.0
TLS2_k127_640209_16 Protein of unknown function (DUF563) - - - 0.00000000000000000000000000000001437 129.0
TLS2_k127_640209_17 Tetratricopeptide repeat - - - 0.00000000000000000000000000001067 132.0
TLS2_k127_640209_18 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.0000000000000003034 93.0
TLS2_k127_640209_19 Putative adhesin - - - 0.0000000000003349 79.0
TLS2_k127_640209_2 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 409.0
TLS2_k127_640209_3 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007929 411.0
TLS2_k127_640209_4 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003899 362.0
TLS2_k127_640209_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008846 286.0
TLS2_k127_640209_6 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001168 289.0
TLS2_k127_640209_7 Antirepressor regulating drug resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000001315 263.0
TLS2_k127_640209_8 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000004242 236.0
TLS2_k127_640209_9 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000004634 241.0
TLS2_k127_6450455_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 3.461e-314 977.0
TLS2_k127_645303_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000001119 224.0
TLS2_k127_645303_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000006715 61.0
TLS2_k127_6465616_0 AbgT putative transporter family K12942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 473.0
TLS2_k127_6465616_1 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000001791 136.0
TLS2_k127_6465616_2 DEAD DEAH box helicase - - - 0.000000001757 61.0
TLS2_k127_6467872_0 Zinc carboxypeptidase - - - 1.096e-224 728.0
TLS2_k127_6467872_1 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004941 434.0
TLS2_k127_6467872_2 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000001647 186.0
TLS2_k127_6467872_3 PFAM von Willebrand factor type A - - - 0.000000000000000000000000002165 121.0
TLS2_k127_647007_0 benzoyl-CoA oxygenase K15512 - 1.14.13.208 1.103e-205 653.0
TLS2_k127_647007_1 Belongs to the aldehyde dehydrogenase family K00128,K00138 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 615.0
TLS2_k127_647007_2 Enoyl-CoA hydratase/isomerase K15513 - 4.1.2.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004836 323.0
TLS2_k127_648577_0 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003866 265.0
TLS2_k127_648577_1 Family 5 K02035 - - 0.0000000000000000000000000008572 125.0
TLS2_k127_648577_2 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000001185 113.0
TLS2_k127_6557240_0 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000001679 241.0
TLS2_k127_6557240_1 Belongs to the ArsC family K00537 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 0.000001483 52.0
TLS2_k127_6557240_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.0001496 44.0
TLS2_k127_6563378_0 MacB-like periplasmic core domain - - - 0.0 1011.0
TLS2_k127_6563378_1 TonB-dependent receptor - - - 5.39e-294 940.0
TLS2_k127_6563378_10 PFAM Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009537 482.0
TLS2_k127_6563378_11 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 459.0
TLS2_k127_6563378_12 PFAM Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 439.0
TLS2_k127_6563378_13 Male sterility protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 443.0
TLS2_k127_6563378_14 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 403.0
TLS2_k127_6563378_15 metallopeptidase activity K06212,K06402 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 376.0
TLS2_k127_6563378_16 cAMP biosynthetic process K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 391.0
TLS2_k127_6563378_17 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 354.0
TLS2_k127_6563378_18 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 314.0
TLS2_k127_6563378_19 helix_turn _helix lactose operon repressor K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 301.0
TLS2_k127_6563378_2 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 1.764e-262 818.0
TLS2_k127_6563378_20 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004939 297.0
TLS2_k127_6563378_21 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 292.0
TLS2_k127_6563378_22 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009475 315.0
TLS2_k127_6563378_23 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 300.0
TLS2_k127_6563378_24 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002003 275.0
TLS2_k127_6563378_25 Evidence 4 Homologs of previously reported genes of K03975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006595 271.0
TLS2_k127_6563378_26 Glycosyl hydrolase family 10 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000017 280.0
TLS2_k127_6563378_27 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000007782 267.0
TLS2_k127_6563378_28 DinB family - - - 0.00000000000000000000000000000000000000000000000000000000000000001314 228.0
TLS2_k127_6563378_29 DinB family - - - 0.00000000000000000000000000000000000000000000000000000000000001701 218.0
TLS2_k127_6563378_3 response to abiotic stimulus K03086 - - 6.8e-201 634.0
TLS2_k127_6563378_30 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000005606 226.0
TLS2_k127_6563378_31 Lipocalin / cytosolic fatty-acid binding protein family K03098 - - 0.000000000000000000000000000000000000000000000000000000871 199.0
TLS2_k127_6563378_32 DinB family - - - 0.0000000000000000000000000000000000000000000002039 173.0
TLS2_k127_6563378_33 Carboxylesterase family - - - 0.0000000000000000000000000000000000000008966 161.0
TLS2_k127_6563378_34 YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the K09780 - - 0.0000000000000000000000000000000000000226 146.0
TLS2_k127_6563378_35 Stress responsive A/B Barrel Domain - - - 0.000000000000000000000000000000000004166 144.0
TLS2_k127_6563378_36 YjbR - - - 0.0000000000000000000000007745 111.0
TLS2_k127_6563378_37 von Willebrand factor, type A - - - 0.000000000000000000000003254 114.0
TLS2_k127_6563378_39 Xylose isomerase-like TIM barrel - - - 0.00000000000000001749 83.0
TLS2_k127_6563378_4 COG0644 Dehydrogenases (flavoproteins) - - - 2.433e-199 636.0
TLS2_k127_6563378_40 Domain of unknown function (DUF305) K08995 - - 0.000000000001072 79.0
TLS2_k127_6563378_41 Protein kinase domain K12132 - 2.7.11.1 0.000000000006114 69.0
TLS2_k127_6563378_42 CsbD-like - - - 0.00000000008804 64.0
TLS2_k127_6563378_43 chorismate lyase activity - - - 0.00000000116 71.0
TLS2_k127_6563378_44 - - - - 0.00000003463 66.0
TLS2_k127_6563378_45 ECF sigma factor - - - 0.00000005624 61.0
TLS2_k127_6563378_46 luxR family - - - 0.00002833 57.0
TLS2_k127_6563378_47 META domain - - - 0.00005395 55.0
TLS2_k127_6563378_5 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 609.0
TLS2_k127_6563378_6 Ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 617.0
TLS2_k127_6563378_7 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 614.0
TLS2_k127_6563378_8 Domain of unknown function (DUF5060) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 548.0
TLS2_k127_6563378_9 COG0635 Coproporphyrinogen III oxidase and related Fe-S - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 499.0
TLS2_k127_6574810_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000001909 271.0
TLS2_k127_6574810_1 Mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000001384 245.0
TLS2_k127_6574810_2 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000000000006022 188.0
TLS2_k127_6574810_3 deoxyhypusine monooxygenase activity - - - 0.00004016 55.0
TLS2_k127_6576278_0 Haloacid dehalogenase-like hydrolase K01194 - 3.2.1.28 0.0 1308.0
TLS2_k127_6576278_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007639 465.0
TLS2_k127_6576278_10 subunit of a heme lyase K02200 - - 0.000000002849 68.0
TLS2_k127_6576278_2 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 381.0
TLS2_k127_6576278_3 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001923 282.0
TLS2_k127_6576278_4 Transcriptional regulator K07013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004931 263.0
TLS2_k127_6576278_5 mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008717 270.0
TLS2_k127_6576278_6 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000000000001566 146.0
TLS2_k127_6576278_7 PFAM Radical SAM domain protein - - - 0.00000000000000000000001535 115.0
TLS2_k127_6576278_8 Pyridoxamine 5'-phosphate oxidase like - - - 0.0000000000000000000002375 105.0
TLS2_k127_6576278_9 Glycosyltransferase like family 2 - - - 0.0000000000003688 82.0
TLS2_k127_6580262_0 Alanine-glyoxylate amino-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 529.0
TLS2_k127_6580262_1 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 396.0
TLS2_k127_6580262_2 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000000002871 167.0
TLS2_k127_6580957_0 PFAM Type II IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004336 265.0
TLS2_k127_6580957_1 Histidine kinase K07636 - 2.7.13.3 0.00000000000000000000000000000004382 129.0
TLS2_k127_6585888_0 Protein of unknown function (DUF1553) - - - 0.0 1046.0
TLS2_k127_6585888_1 Protein of unknown function (DUF1501) - - - 2.46e-225 706.0
TLS2_k127_6585888_2 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000004833 97.0
TLS2_k127_6600211_0 - - - - 0.0000000000000000000000000002941 121.0
TLS2_k127_6600211_1 Surface antigen variable number K07277 - - 0.00002136 57.0
TLS2_k127_6600343_1 Pfam:N_methyl_2 - - - 0.00002675 56.0
TLS2_k127_6600343_2 protein transport across the cell outer membrane K02246,K08084 - - 0.00004764 52.0
TLS2_k127_6600343_3 Prokaryotic N-terminal methylation motif K02671 - - 0.0004929 49.0
TLS2_k127_6603093_0 PFAM regulator of chromosome condensation, RCC1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008942 285.0
TLS2_k127_6603093_1 metallopeptidase activity - - - 0.000000000000000000000000000000000000000000002228 186.0
TLS2_k127_6603093_2 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000001199 172.0
TLS2_k127_6609667_0 Polysaccharide biosynthesis protein K01784,K08679 - 5.1.3.2,5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000775 381.0
TLS2_k127_6609667_1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840 - 5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 328.0
TLS2_k127_6609667_2 PFAM transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 306.0
TLS2_k127_6609667_3 Ribulose-phosphate 3 epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.00000000000000000000000000000000000000000000000000000008996 200.0
TLS2_k127_6609667_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000000000000004873 162.0
TLS2_k127_6609667_5 thioesterase K07107 - - 0.00000000000000000000000000000000009584 138.0
TLS2_k127_6609667_6 Tetratricopeptide repeat K05807 - - 0.000000000000000000000003279 113.0
TLS2_k127_6610193_0 Multicopper oxidase K08100 - 1.3.3.5 6.568e-313 975.0
TLS2_k127_6610193_1 L-seryl-tRNASec selenium transferase activity K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 421.0
TLS2_k127_6610193_2 Amino acid kinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 420.0
TLS2_k127_6610193_3 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 403.0
TLS2_k127_6610193_4 ATPase activity K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000003146 245.0
TLS2_k127_6610193_5 DoxX - - - 0.00000000000000000000000000000000000000000001107 169.0
TLS2_k127_6610193_6 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000003373 164.0
TLS2_k127_6610193_7 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.0000000000000000000000000000000000000001895 153.0
TLS2_k127_6610193_8 Amidohydrolase family K01465 - 3.5.2.3 0.0000000000001772 72.0
TLS2_k127_6610193_9 Amidohydrolase family K01465 - 3.5.2.3 0.0000000324 57.0
TLS2_k127_6613419_0 Carbohydrate family 9 binding domain-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 302.0
TLS2_k127_6613419_1 Adenylate cyclase - - - 0.00000000000000001784 91.0
TLS2_k127_6613419_2 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000004489 87.0
TLS2_k127_6613419_3 ABC-2 type transporter - - - 0.00000000000004861 81.0
TLS2_k127_6614068_0 Predicted membrane protein (DUF2254) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 323.0
TLS2_k127_6614068_1 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.000000000000000000000000000000000000000000000000000000000000000001404 235.0
TLS2_k127_6614068_2 AAA domain K00851 - 2.7.1.12 0.00000000000000000000000000000000000003039 157.0
TLS2_k127_6614068_3 transmembrane signaling receptor activity K03406 - - 0.00000000000000000000001504 111.0
TLS2_k127_6620338_0 4 iron, 4 sulfur cluster binding K03737 - 1.2.7.1 5.578e-278 864.0
TLS2_k127_6620338_1 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 368.0
TLS2_k127_6620338_2 Fe-S cluster K03616 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000203 288.0
TLS2_k127_6620338_3 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000004124 268.0
TLS2_k127_6622665_0 Pyrrolo-quinoline quinone K00114 - 1.1.2.8 4.111e-293 909.0
TLS2_k127_6622665_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.357e-255 803.0
TLS2_k127_6622665_2 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K17223 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 339.0
TLS2_k127_6622665_3 Extracellular solute-binding protein, family 3 K16254 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 311.0
TLS2_k127_6622665_4 Cytochrome c oxidase subunit III - - - 0.000000000000000000000000000000000000000000000000004008 205.0
TLS2_k127_6622665_5 electron transfer activity K02275,K02305,K08738,K17223 - 1.9.3.1 0.00000000000000000000000000000000000782 146.0
TLS2_k127_6622665_6 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.000000000000000000000000000003318 128.0
TLS2_k127_6622665_7 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.000000000000003879 77.0
TLS2_k127_6627554_0 domain protein - - - 0.0 1024.0
TLS2_k127_6627554_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 2.467e-300 958.0
TLS2_k127_6627554_10 Elongator protein 3, MiaB family, Radical SAM K06936 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001826 298.0
TLS2_k127_6627554_11 Binding-protein-dependent transport system inner membrane component K02050,K15554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001234 282.0
TLS2_k127_6627554_12 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006278 294.0
TLS2_k127_6627554_13 repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001958 287.0
TLS2_k127_6627554_14 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003017 279.0
TLS2_k127_6627554_15 anion transmembrane transporter activity K02049,K15555,K15558 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005375 273.0
TLS2_k127_6627554_16 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000009087 222.0
TLS2_k127_6627554_17 DNA-templated transcription, initiation K02405 - - 0.0000000000000000000000000000000000000005535 158.0
TLS2_k127_6627554_18 hydroperoxide reductase activity K01607 - 4.1.1.44 0.000000000000000000000000000000001459 131.0
TLS2_k127_6627554_19 - - - - 0.000000000000000000000000000000008994 129.0
TLS2_k127_6627554_2 peroxiredoxin activity - - - 5.859e-248 807.0
TLS2_k127_6627554_21 - - - - 0.0009869 50.0
TLS2_k127_6627554_3 asparagine synthase K01953 - 6.3.5.4 1.543e-199 629.0
TLS2_k127_6627554_4 geranylgeranyl reductase activity K14257 - 1.14.19.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005046 546.0
TLS2_k127_6627554_5 Transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 484.0
TLS2_k127_6627554_6 positive regulation of growth rate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009068 453.0
TLS2_k127_6627554_7 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 411.0
TLS2_k127_6627554_8 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 367.0
TLS2_k127_6627554_9 electron transport chain K00347,K03614,K21163 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004188 320.0
TLS2_k127_6645564_0 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 2.894e-212 666.0
TLS2_k127_6645564_1 Periplasmic component of the Tol biopolymer transport system - - - 1.87e-211 671.0
TLS2_k127_6645564_10 Cro/C1-type HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000004675 213.0
TLS2_k127_6645564_11 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000003653 188.0
TLS2_k127_6645564_12 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000441 181.0
TLS2_k127_6645564_13 Cupin 2, conserved barrel domain protein K00971,K19547 - 2.7.7.13,5.3.3.19 0.00000000000000000000000000000000002419 142.0
TLS2_k127_6645564_14 cyclic nucleotide binding K07001,K10914 - - 0.0000000000000000000000000000000537 134.0
TLS2_k127_6645564_15 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.000000000000000000000000001837 126.0
TLS2_k127_6645564_16 Cold shock protein domain - - - 0.000000000001189 70.0
TLS2_k127_6645564_17 Cold shock K03704 - - 0.00000000001201 67.0
TLS2_k127_6645564_2 Carbohydrate family 9 binding domain-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 616.0
TLS2_k127_6645564_3 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008492 508.0
TLS2_k127_6645564_4 cAMP biosynthetic process K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 357.0
TLS2_k127_6645564_5 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 337.0
TLS2_k127_6645564_6 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 334.0
TLS2_k127_6645564_7 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 300.0
TLS2_k127_6645564_8 PAP2 superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 307.0
TLS2_k127_6645564_9 Psort location K03776 - - 0.000000000000000000000000000000000000000000000000000000000000000000003535 253.0
TLS2_k127_6646064_0 Glycoside hydrolase family 16 - - - 3.784e-227 747.0
TLS2_k127_6646064_1 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 1.653e-195 633.0
TLS2_k127_6646064_10 - - - - 0.0000000000000000000000000005115 123.0
TLS2_k127_6646064_11 zinc ion binding - - - 0.0007461 50.0
TLS2_k127_6646064_2 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 523.0
TLS2_k127_6646064_3 Ankyrin repeats (3 copies) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 440.0
TLS2_k127_6646064_4 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000889 364.0
TLS2_k127_6646064_5 amine dehydrogenase activity K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007645 365.0
TLS2_k127_6646064_6 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 335.0
TLS2_k127_6646064_7 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000258 285.0
TLS2_k127_6646064_8 ECF sigma factor - - - 0.0000000000000000000000000000000000000000007413 178.0
TLS2_k127_6646064_9 PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000000000000000000000001617 141.0
TLS2_k127_6646094_0 metalloendopeptidase activity K01283 - 3.4.15.1 5.458e-236 741.0
TLS2_k127_6654587_0 DEAD DEAH box K03724 - - 0.0 1928.0
TLS2_k127_6654587_1 PFAM alpha amylase, catalytic K06044 - 5.4.99.15 3.508e-235 749.0
TLS2_k127_6654587_10 Peptidase family M23 K21472 - - 0.00000000000000000000000000000000000000000000000002008 188.0
TLS2_k127_6654587_11 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000001389 181.0
TLS2_k127_6654587_12 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase K07029 GO:0003674,GO:0003824,GO:0004143,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237 2.7.1.107 0.0000000000000000000000000000000000000000000001563 180.0
TLS2_k127_6654587_13 - - - - 0.00000000000000000000000000000000000001652 158.0
TLS2_k127_6654587_14 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 - 1.6.5.3 0.00000000000000000000000000000000000004677 147.0
TLS2_k127_6654587_15 Thioredoxin-like [2Fe-2S] ferredoxin K03943 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0016020,GO:0019866,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0070469,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000001701 154.0
TLS2_k127_6654587_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000001354 141.0
TLS2_k127_6654587_17 Domain of unknown function (DUF4956) - - - 0.0000000000000003172 91.0
TLS2_k127_6654587_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 522.0
TLS2_k127_6654587_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 451.0
TLS2_k127_6654587_4 Belongs to the FPG family K05522 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 346.0
TLS2_k127_6654587_5 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 367.0
TLS2_k127_6654587_6 peptidoglycan-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001411 289.0
TLS2_k127_6654587_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000004451 242.0
TLS2_k127_6654587_8 Protein of unknown function (DUF520) K09767 - - 0.00000000000000000000000000000000000000000000000000002338 192.0
TLS2_k127_6654587_9 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000001072 196.0
TLS2_k127_6659686_0 MacB-like periplasmic core domain - - - 6.782e-225 722.0
TLS2_k127_6659686_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 537.0
TLS2_k127_6659686_10 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006123 279.0
TLS2_k127_6659686_11 PFAM Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001181 282.0
TLS2_k127_6659686_12 TLC ATP/ADP transporter K03301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002528 290.0
TLS2_k127_6659686_13 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - - 0.000000000000000000000000000000000000000000000000000000000102 220.0
TLS2_k127_6659686_14 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000001618 208.0
TLS2_k127_6659686_15 Carbohydrate family 9 binding domain-like - - - 0.00000000000000000000000000000000000000000000000001474 201.0
TLS2_k127_6659686_16 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000149 160.0
TLS2_k127_6659686_17 Aminoacyl-tRNA editing domain K19055 - - 0.000000000000000000000000000000000003466 149.0
TLS2_k127_6659686_18 Carboxypeptidase regulatory-like domain - - - 0.000009281 58.0
TLS2_k127_6659686_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 516.0
TLS2_k127_6659686_3 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 426.0
TLS2_k127_6659686_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 413.0
TLS2_k127_6659686_5 Periplasmic binding proteins and sugar binding domain of LacI family K10439,K10552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 400.0
TLS2_k127_6659686_6 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 396.0
TLS2_k127_6659686_7 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 346.0
TLS2_k127_6659686_8 HDOD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004928 331.0
TLS2_k127_6659686_9 translation initiation factor activity K06996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008201 292.0
TLS2_k127_6660826_0 phosphoesterase, PA-phosphatase related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 485.0
TLS2_k127_6660826_1 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007327 404.0
TLS2_k127_6660826_2 Belongs to the peptidase S8 family K17734 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 349.0
TLS2_k127_6660826_3 protein homotetramerization - - - 0.00000000000000000000000000000000001113 145.0
TLS2_k127_6660826_4 DinB family - - - 0.000000000000001834 83.0
TLS2_k127_6670596_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 1.523e-264 835.0
TLS2_k127_6670596_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 3.94e-223 733.0
TLS2_k127_6670596_10 PFAM peptidase S58, DmpA K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 345.0
TLS2_k127_6670596_11 aromatic amino acid beta-eliminating lyase threonine aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 353.0
TLS2_k127_6670596_12 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002211 280.0
TLS2_k127_6670596_13 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000006096 261.0
TLS2_k127_6670596_14 Rhodanese-like domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000004406 243.0
TLS2_k127_6670596_15 Pfam Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000003581 245.0
TLS2_k127_6670596_16 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000003299 205.0
TLS2_k127_6670596_17 PFAM Rhomboid family - - - 0.0000000000000000000000000000000000000000000001304 177.0
TLS2_k127_6670596_18 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000003074 171.0
TLS2_k127_6670596_19 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000003023 173.0
TLS2_k127_6670596_2 Peptidase dimerisation domain K01436,K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 529.0
TLS2_k127_6670596_20 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K01838 - 5.4.2.6 0.000000000000000000000000000000000005017 145.0
TLS2_k127_6670596_21 PFAM Cupin 2, conserved barrel - - - 0.00000000000000000000000000000002358 132.0
TLS2_k127_6670596_22 Protein of unknown function (DUF1684) K09164 - - 0.00000000000000000000000000000002583 141.0
TLS2_k127_6670596_23 phosphinothricin N-acetyltransferase activity - - - 0.0000000000000000000000000000002237 140.0
TLS2_k127_6670596_24 ABC-2 family transporter protein - - - 0.000000000000000000000000000962 125.0
TLS2_k127_6670596_25 Yqey-like protein K09117 - - 0.00000000000000000000000001048 117.0
TLS2_k127_6670596_26 Glycosyl transferase - - - 0.00000000000000000000003732 113.0
TLS2_k127_6670596_27 - - - - 0.0000000000000000000004997 100.0
TLS2_k127_6670596_28 hydrolase activity, acting on ester bonds - - - 0.0000000002473 70.0
TLS2_k127_6670596_29 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate - - - 0.000000004518 69.0
TLS2_k127_6670596_3 PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005119 550.0
TLS2_k127_6670596_30 Lysophospholipase L1 and related - - - 0.00000002261 66.0
TLS2_k127_6670596_31 lipopolysaccharide biosynthesis protein - - - 0.00002307 57.0
TLS2_k127_6670596_4 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007911 486.0
TLS2_k127_6670596_5 TAT (twin-arginine translocation) pathway signal sequence - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 454.0
TLS2_k127_6670596_6 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 447.0
TLS2_k127_6670596_7 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007789 432.0
TLS2_k127_6670596_8 symporter activity K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 413.0
TLS2_k127_6670596_9 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 411.0
TLS2_k127_6708600_0 Belongs to the glycosyl hydrolase 31 family K01811 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.177 8.79e-263 840.0
TLS2_k127_6708600_1 radical SAM domain protein K22318 - - 1.274e-231 730.0
TLS2_k127_6708600_2 Protein of unknown function (DUF1549) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 572.0
TLS2_k127_6708600_3 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009445 385.0
TLS2_k127_6708600_4 lipid kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000004452 227.0
TLS2_k127_6721969_0 MacB-like periplasmic core domain - - - 2.098e-319 997.0
TLS2_k127_6721969_1 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs - - - 2.22e-269 851.0
TLS2_k127_6721969_10 - - - - 0.00000000000000000000001605 109.0
TLS2_k127_6721969_11 metal-dependent phosphoesterases (PHP family) - - - 0.0000000000004596 79.0
TLS2_k127_6721969_12 META domain K09914 - - 0.000000000001483 71.0
TLS2_k127_6721969_13 - - - - 0.00000000007388 73.0
TLS2_k127_6721969_2 Acetyl xylan esterase (AXE1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 560.0
TLS2_k127_6721969_3 PFAM Cys Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 518.0
TLS2_k127_6721969_4 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009158 378.0
TLS2_k127_6721969_5 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 346.0
TLS2_k127_6721969_6 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 306.0
TLS2_k127_6721969_7 2Fe-2S -binding domain protein K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000676 235.0
TLS2_k127_6721969_8 COGs COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase - - - 0.000000000000000000000000000000000000000000000000000002954 201.0
TLS2_k127_6721969_9 Transcriptional regulator - - - 0.00000000000000000000000000000000002519 146.0
TLS2_k127_673275_0 Prolyl oligopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 592.0
TLS2_k127_673275_1 alpha-L-arabinofuranosidase K01209 - 3.2.1.55 0.0000000000000000000000000000000000000000000000000000000000000008672 240.0
TLS2_k127_6748558_0 leukotriene A-4 hydrolase - - - 4.512e-209 669.0
TLS2_k127_6748558_1 Peptidase, M61 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 580.0
TLS2_k127_6748558_10 3-demethylubiquinone-9 3-O-methyltransferase activity K00694,K11936,K20541 - 2.4.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006334 383.0
TLS2_k127_6748558_11 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 314.0
TLS2_k127_6748558_12 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005577 267.0
TLS2_k127_6748558_13 Transcription factor zinc-finger - - - 0.000000000000000000000000000000000000000000001921 175.0
TLS2_k127_6748558_14 Thioredoxin K03672 - 1.8.1.8 0.0000000000000000000000000000000007202 135.0
TLS2_k127_6748558_15 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000002491 61.0
TLS2_k127_6748558_16 TonB-dependent receptor - - - 0.00001235 55.0
TLS2_k127_6748558_17 Putative zinc- or iron-chelating domain K18475 - - 0.0002597 54.0
TLS2_k127_6748558_2 epimerase dehydratase K12454 - 5.1.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005944 516.0
TLS2_k127_6748558_3 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 494.0
TLS2_k127_6748558_4 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007581 426.0
TLS2_k127_6748558_5 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 425.0
TLS2_k127_6748558_6 ATPases associated with a variety of cellular activities K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004257 419.0
TLS2_k127_6748558_7 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 377.0
TLS2_k127_6748558_8 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 364.0
TLS2_k127_6748558_9 COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 352.0
TLS2_k127_6756628_0 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 409.0
TLS2_k127_6756628_1 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 342.0
TLS2_k127_6756628_2 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000002622 120.0
TLS2_k127_6771131_0 Cystathionine beta-synthase K01697 - 4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 626.0
TLS2_k127_6771131_1 glycogen (starch) synthase activity K16148 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 2.4.1.342 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 500.0
TLS2_k127_6771131_2 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 299.0
TLS2_k127_6771131_3 Anti-sigma-K factor rskA - - - 0.00002767 57.0
TLS2_k127_6772344_0 Cytochrome c554 and c-prime - - - 0.0 1055.0
TLS2_k127_6772344_1 ASPIC and UnbV - - - 0.00000000000000000000000000000000000003776 153.0
TLS2_k127_6773255_0 PFAM Blue (type 1) copper domain K09992 - - 0.0 1123.0
TLS2_k127_6773255_1 and related - - - 1.187e-198 624.0
TLS2_k127_6773255_10 Protein conserved in bacteria - - - 0.00000000000000000000000000000000003447 142.0
TLS2_k127_6773255_11 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000003196 129.0
TLS2_k127_6773255_12 GDYXXLXY protein - - - 0.0000000000000000000000002166 123.0
TLS2_k127_6773255_13 ECF sigma factor - - - 0.000000000000002482 79.0
TLS2_k127_6773255_14 - - - - 0.0000000000001573 74.0
TLS2_k127_6773255_15 Histidine kinase - - - 0.00000001455 66.0
TLS2_k127_6773255_2 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 503.0
TLS2_k127_6773255_3 OmpA family K02557,K03286 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 431.0
TLS2_k127_6773255_4 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 387.0
TLS2_k127_6773255_5 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 312.0
TLS2_k127_6773255_6 Maltose acetyltransferase K00661 - 2.3.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000006447 255.0
TLS2_k127_6773255_7 GTP binding - - - 0.0000000000000000000000000000000000000000000000000000001151 209.0
TLS2_k127_6773255_8 Predicted membrane protein (DUF2157) - - - 0.0000000000000000000000000000000000000000000000009484 192.0
TLS2_k127_6773255_9 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000001436 147.0
TLS2_k127_6778602_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 458.0
TLS2_k127_6781034_0 PFAM histone deacetylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000354 254.0
TLS2_k127_6781034_1 Proline racemase K01777 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0018112,GO:0019752,GO:0036361,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0071704,GO:1901564 5.1.1.4 0.000000000000000000000000000000000000000000009428 180.0
TLS2_k127_6781034_2 PFAM KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.00000000000000000000000000000001373 130.0
TLS2_k127_6781034_3 PFAM PBS lyase HEAT-like repeat - - - 0.000000002357 68.0
TLS2_k127_6796781_0 ATP dependent DNA ligase domain protein K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 603.0
TLS2_k127_6796781_1 ATP dependent DNA ligase C terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 518.0
TLS2_k127_6796781_2 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 368.0
TLS2_k127_6796781_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 337.0
TLS2_k127_6796781_4 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000002927 193.0
TLS2_k127_6796781_5 ECF sigma factor - - - 0.0000000000000000000000000000000000000000002773 166.0
TLS2_k127_6796781_7 Belongs to the glycosyl hydrolase 2 family K01190 - 3.2.1.23 0.00002678 52.0
TLS2_k127_6796781_8 - - - - 0.0005888 50.0
TLS2_k127_6836158_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1343.0
TLS2_k127_6836158_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1168.0
TLS2_k127_6836158_10 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000001999 256.0
TLS2_k127_6836158_11 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000003708 249.0
TLS2_k127_6836158_12 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000003393 188.0
TLS2_k127_6836158_13 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.000000000000000000000000000000000000000179 162.0
TLS2_k127_6836158_14 Protein of unknown function (DUF2490) - - - 0.0000000000002234 83.0
TLS2_k127_6836158_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 4.76e-199 631.0
TLS2_k127_6836158_3 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008205 593.0
TLS2_k127_6836158_4 von Willebrand factor (vWF) type A domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 512.0
TLS2_k127_6836158_5 S-acyltransferase activity K00627 GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008639 493.0
TLS2_k127_6836158_6 gluconolactonase K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007049 405.0
TLS2_k127_6836158_7 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 388.0
TLS2_k127_6836158_8 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 375.0
TLS2_k127_6836158_9 Belongs to the UPF0173 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001251 267.0
TLS2_k127_6847438_0 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 435.0
TLS2_k127_6847438_1 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 394.0
TLS2_k127_6847438_2 PFAM TonB-dependent Receptor Plug - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 371.0
TLS2_k127_6847438_3 formate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000152 276.0
TLS2_k127_6847438_4 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002616 261.0
TLS2_k127_6847438_5 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003972 264.0
TLS2_k127_6847438_6 COG0694 Thioredoxin-like proteins and domains - - - 0.00000000000000006401 85.0
TLS2_k127_6847438_7 Cytochrome c K00413 - - 0.00000000001785 71.0
TLS2_k127_6847438_8 WD40 domain protein beta Propeller - - - 0.0000000009447 65.0
TLS2_k127_6847438_9 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives K02343 - 2.7.7.7 0.00000003734 60.0
TLS2_k127_6859358_0 Protein of unknown function (DUF4038) - - - 7.481e-201 634.0
TLS2_k127_6859358_1 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000001014 173.0
TLS2_k127_6859358_2 Penicillinase repressor - - - 0.00000000000000000000000000000000002063 138.0
TLS2_k127_6859358_3 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000001791 143.0
TLS2_k127_6859358_4 PFAM Acetyltransferase (GNAT) family K03790 - 2.3.1.128 0.0000000000000000000000000001316 123.0
TLS2_k127_6859358_5 BlaR1 peptidase M56 - - - 0.000000000000000000000005603 115.0
TLS2_k127_6880735_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 460.0
TLS2_k127_6880735_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 425.0
TLS2_k127_6880735_2 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007535 351.0
TLS2_k127_6880735_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 313.0
TLS2_k127_6880735_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000001244 196.0
TLS2_k127_6880735_5 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000002239 159.0
TLS2_k127_6880735_6 methyltransferase K21459 - 2.1.1.301 0.0000000000000000008627 98.0
TLS2_k127_6880735_7 Methionine biosynthesis protein MetW - - - 0.00000000000002816 83.0
TLS2_k127_688161_0 Fungalysin metallopeptidase (M36) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 531.0
TLS2_k127_688161_1 Fungalysin metallopeptidase (M36) - - - 0.00000000000005145 80.0
TLS2_k127_6899728_0 Putative transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 578.0
TLS2_k127_6899728_1 Phage integrase family - - - 0.00000000000000000000000000000000000000000000000000000003385 199.0
TLS2_k127_6899728_2 Phage integrase, N-terminal SAM-like domain - - - 0.0000000000000000000000000000000000000000000000000001906 193.0
TLS2_k127_6926497_0 Membrane-bound dehydrogenase domain protein - - - 2.922e-273 879.0
TLS2_k127_6926497_1 Membrane-bound dehydrogenase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000004112 232.0
TLS2_k127_6926497_2 Trehalose utilisation - - - 0.0000000000000000000000000000000000000000000000000000000000001618 238.0
TLS2_k127_6926497_3 PFAM Cys Met metabolism pyridoxal-phosphate- dependent protein K01740,K10764 - 2.5.1.49 0.0009163 43.0
TLS2_k127_6929899_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008664 602.0
TLS2_k127_6929899_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 366.0
TLS2_k127_6929899_10 Belongs to the bacterial ribosomal protein bL34 family K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000001784 69.0
TLS2_k127_6929899_11 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000001278 59.0
TLS2_k127_6929899_12 ATP synthesis coupled proton transport K02109,K18682 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000009882 60.0
TLS2_k127_6929899_2 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 304.0
TLS2_k127_6929899_3 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007231 295.0
TLS2_k127_6929899_4 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004428 298.0
TLS2_k127_6929899_5 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000009056 241.0
TLS2_k127_6929899_6 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000007201 95.0
TLS2_k127_6929899_7 R3H domain protein K06346 - - 0.0000000000000004611 91.0
TLS2_k127_6929899_8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000000006369 82.0
TLS2_k127_6929899_9 Ribosomal RNA small subunit methyltransferase G K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.00000000000001627 82.0
TLS2_k127_6948619_0 Peptidase family M50 K11749 - - 0.0000000000000000000000116 103.0
TLS2_k127_6948619_1 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.00000000000000002697 84.0
TLS2_k127_6948619_2 Tfp pilus assembly protein FimV - - - 0.0000000000005499 81.0
TLS2_k127_6948634_0 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 339.0
TLS2_k127_6948634_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.00000000000000000000000004454 109.0
TLS2_k127_6948634_2 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.00000000000000001431 85.0
TLS2_k127_6948634_3 Tfp pilus assembly protein FimV - - - 0.00000000000003234 85.0
TLS2_k127_6950433_0 Part of a membrane complex involved in electron transport K03614 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 319.0
TLS2_k127_6950433_1 Part of a membrane complex involved in electron transport K03615 - - 0.000000000000000000000000000000000000000000000000000000000000000000006403 239.0
TLS2_k127_6950433_2 Part of a membrane complex involved in electron transport - - - 0.000000000000000000000000002148 128.0
TLS2_k127_6952316_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0000000000000009024 81.0
TLS2_k127_6982878_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000003604 239.0
TLS2_k127_6989606_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 2.057e-223 712.0
TLS2_k127_6989606_1 ABC transporter K06147,K18890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008577 623.0
TLS2_k127_6989606_10 3D domain - - - 0.0000000000000001907 88.0
TLS2_k127_6989606_11 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000000000009415 85.0
TLS2_k127_6989606_12 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000579 61.0
TLS2_k127_6989606_13 - - - - 0.0001792 48.0
TLS2_k127_6989606_2 ABC transporter, transmembrane K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 558.0
TLS2_k127_6989606_3 Endoribonuclease that initiates mRNA decay K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 522.0
TLS2_k127_6989606_4 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 449.0
TLS2_k127_6989606_5 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 360.0
TLS2_k127_6989606_6 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000001626 226.0
TLS2_k127_6989606_7 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000881 211.0
TLS2_k127_6989606_8 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000009418 140.0
TLS2_k127_6989606_9 Domain of unknown function (DUF4383) - - - 0.000000000000000000000000000000005302 132.0
TLS2_k127_6997306_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 8.22e-262 824.0
TLS2_k127_6997306_1 PFAM glycoside hydrolase family 3 domain protein K05349 - 3.2.1.21 2.81e-232 736.0
TLS2_k127_6997306_10 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000002094 222.0
TLS2_k127_6997306_11 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000004749 205.0
TLS2_k127_6997306_12 Nucleotidyl transferase K00966,K16881 - 2.7.7.13,5.4.2.8 0.0000000000000000000000000000000000000000000007277 180.0
TLS2_k127_6997306_13 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000000000000001576 147.0
TLS2_k127_6997306_14 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000009188 125.0
TLS2_k127_6997306_15 PFAM Adenylate cyclase K05873 - 4.6.1.1 0.00000000000000000000003458 108.0
TLS2_k127_6997306_16 peptidyl-tyrosine sulfation K13992 - - 0.00000000000000004841 87.0
TLS2_k127_6997306_2 PFAM tRNA synthetase, class II (D, K and N) K01893 - 6.1.1.22 4.856e-195 617.0
TLS2_k127_6997306_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 469.0
TLS2_k127_6997306_4 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 406.0
TLS2_k127_6997306_5 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004165 409.0
TLS2_k127_6997306_6 proline dipeptidase activity K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 356.0
TLS2_k127_6997306_7 PFAM peptidase S1 and S6 chymotrypsin Hap K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 317.0
TLS2_k127_6997306_8 - K06862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000202 241.0
TLS2_k127_6997306_9 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000003536 225.0
TLS2_k127_7017255_0 peptidoglycan glycosyltransferase activity K03588,K05364,K05837 GO:0002682,GO:0002684,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 - 1.074e-240 782.0
TLS2_k127_7017255_1 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001611 295.0
TLS2_k127_7017255_2 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001789 285.0
TLS2_k127_7017255_3 histone H2A K63-linked ubiquitination K01768,K03220,K10914 - 4.6.1.1 0.000000000000000000000000000000000003072 153.0
TLS2_k127_7017255_4 histone H2A K63-linked ubiquitination K02283 - - 0.0000000000000000000000003259 115.0
TLS2_k127_7017255_5 - - - - 0.0000000000000000001413 95.0
TLS2_k127_7017255_6 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000004936 87.0
TLS2_k127_7017255_7 FHA domain containing protein - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.0000000007716 68.0
TLS2_k127_7032070_0 4 iron, 4 sulfur cluster binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 586.0
TLS2_k127_7032070_1 Na H antiporter K03315 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006894 550.0
TLS2_k127_7032070_2 5'-3' exonuclease, N-terminal resolvase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 415.0
TLS2_k127_7032070_3 Aminotransferase class I and II K00375 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 336.0
TLS2_k127_7032070_4 TonB-dependent Receptor Plug Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 306.0
TLS2_k127_7032070_5 beta-keto acid cleavage enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005285 292.0
TLS2_k127_7032070_6 signal peptide processing K03100 - 3.4.21.89 0.00000000000000000000000004986 127.0
TLS2_k127_7032070_7 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family - - - 0.0000000000000000000000001564 123.0
TLS2_k127_7032070_8 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000001177 97.0
TLS2_k127_7032070_9 Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway K15521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 2.4.1.250 0.00000000004814 75.0
TLS2_k127_7034070_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002432 258.0
TLS2_k127_7034070_1 Polysaccharide deacetylase K22278 - 3.5.1.104 0.000000000000000000000000000000000000000000000000000000000000000000002757 248.0
TLS2_k127_7034070_2 acetyltransferase - - - 0.00000000000000000000000000000002954 128.0
TLS2_k127_7069224_0 alpha-L-fucosidase K15923 - 3.2.1.51 2.241e-277 882.0
TLS2_k127_7069224_1 Flavin containing amine oxidoreductase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 1.534e-244 768.0
TLS2_k127_7069224_10 - - - - 0.000000000000000000000000003572 117.0
TLS2_k127_7069224_11 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000001066 105.0
TLS2_k127_7069224_12 Surface antigen - - - 0.00005296 56.0
TLS2_k127_7069224_2 lycopene cyclase K06443 - 5.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000083 440.0
TLS2_k127_7069224_3 Pfam Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004234 351.0
TLS2_k127_7069224_4 aldo keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 344.0
TLS2_k127_7069224_5 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 298.0
TLS2_k127_7069224_6 Phytoene squalene synthetase K02291 GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 309.0
TLS2_k127_7069224_7 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004735 277.0
TLS2_k127_7069224_8 hydroxylase K15746 - 1.14.15.24 0.000000000000000000000000000000000000000000000000000000005622 202.0
TLS2_k127_7069224_9 creatininase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000007749 204.0
TLS2_k127_70873_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1585.0
TLS2_k127_70873_1 acyl-CoA dehydrogenase activity K00249 - 1.3.8.7 0.0 1032.0
TLS2_k127_70873_10 peptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000007407 235.0
TLS2_k127_70873_11 Protein of unknown function (DUF664) - - - 0.000000000000000000000000000005322 124.0
TLS2_k127_70873_12 - - - - 0.000000000000001897 76.0
TLS2_k127_70873_2 oxidoreductase K00311,K00313 - 1.5.5.1 5.821e-217 688.0
TLS2_k127_70873_3 glucosamine-6-phosphate deaminase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 530.0
TLS2_k127_70873_4 PFAM Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006945 486.0
TLS2_k127_70873_5 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 461.0
TLS2_k127_70873_6 fatty acid beta-oxidation using acyl-CoA dehydrogenase K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 415.0
TLS2_k127_70873_7 electron transfer activity K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 348.0
TLS2_k127_70873_8 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001001 274.0
TLS2_k127_70873_9 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004737 277.0
TLS2_k127_7104803_0 Flavin containing amine oxidoreductase - - - 3.173e-257 806.0
TLS2_k127_7104803_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 537.0
TLS2_k127_7104803_2 Periplasmic component of the Tol biopolymer transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 449.0
TLS2_k127_7104803_3 Pantothenic acid kinase K00867 GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 415.0
TLS2_k127_7104803_4 Pfam:DUF1498 K09988 - 5.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000007312 259.0
TLS2_k127_7104803_5 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179 - 3.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000495 257.0
TLS2_k127_7104803_6 PFAM OsmC family protein K04063 - - 0.000000000000000000000000000000000000000001984 174.0
TLS2_k127_7104803_7 TIGRFAM phytoene desaturase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.00000000000000000000002509 116.0
TLS2_k127_7108395_0 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 339.0
TLS2_k127_7108395_1 extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005785 342.0
TLS2_k127_7108395_10 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000004672 134.0
TLS2_k127_7108395_11 Hydrolase K21471 - - 0.0000000000000000000000000008108 121.0
TLS2_k127_7108395_12 - - - - 0.000000000000036 83.0
TLS2_k127_7108395_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001349 267.0
TLS2_k127_7108395_3 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000396 280.0
TLS2_k127_7108395_4 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002747 256.0
TLS2_k127_7108395_5 HNH nucleases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004878 254.0
TLS2_k127_7108395_6 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007216 262.0
TLS2_k127_7108395_7 Belongs to the DapA family K01714,K22397 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0047440,GO:0071704,GO:0072329,GO:1901575 4.1.2.28,4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000001886 245.0
TLS2_k127_7108395_8 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000001771 214.0
TLS2_k127_7108395_9 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008955,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.129 0.00000000000000000000000000000000000000000000000000001746 197.0
TLS2_k127_7112358_0 PFAM sigma-54 factor interaction domain-containing protein K02584 - - 4.144e-207 659.0
TLS2_k127_7112358_1 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006918 256.0
TLS2_k127_7133492_0 membrane - - - 0.000000000000000001048 89.0
TLS2_k127_717464_0 alpha beta - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 488.0
TLS2_k127_717464_1 phosphorelay signal transduction system K02481,K07713,K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 463.0
TLS2_k127_717464_2 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000006984 239.0
TLS2_k127_717464_3 phosphorelay sensor kinase activity - - - 0.00000000000000000000000000000000000000000004774 181.0
TLS2_k127_717464_4 - - - - 0.000000000000000000000000000000000000000008236 165.0
TLS2_k127_717464_5 Protein of unknown function (DUF3365) - - - 0.00000000000000000000001876 108.0
TLS2_k127_717464_6 - - - - 0.000000000000000000007404 106.0
TLS2_k127_717464_8 - - - - 0.0000005043 63.0
TLS2_k127_717464_9 - - - - 0.0001157 51.0
TLS2_k127_7197964_0 Glycosyl hydrolase, family 20, catalytic domain - - - 2.747e-252 799.0
TLS2_k127_7197964_1 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 371.0
TLS2_k127_7197964_2 - - - - 0.0000000000000000000000000000000000000000005517 162.0
TLS2_k127_7197964_3 Metal dependent phosphohydrolases with conserved 'HD' motif. K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000000000000002601 167.0
TLS2_k127_7197964_4 PFAM Ethyl tert-butyl ether degradation EthD - - - 0.00003002 48.0
TLS2_k127_7258090_0 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 442.0
TLS2_k127_7258090_1 alanine symporter K03310 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004422 366.0
TLS2_k127_7263772_0 family 43 - - - 2.77e-291 907.0
TLS2_k127_7263772_1 Belongs to the mandelate racemase muconate lactonizing enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000007091 238.0
TLS2_k127_7276608_0 Domain of Unknown Function with PDB structure (DUF3857) - - - 5.977e-201 668.0
TLS2_k127_7276608_1 Tryptophan-rich sensory protein K05770 - - 0.0000000000000000000000000000000000000000000000000000000000004564 214.0
TLS2_k127_7276608_2 - - - - 0.00000000009095 71.0
TLS2_k127_7276608_3 Aminotransferase class I and II K00817 - 2.6.1.9 0.0000006531 55.0
TLS2_k127_733488_0 Oxidoreductase - - - 3.613e-262 817.0
TLS2_k127_733488_1 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 1.921e-245 784.0
TLS2_k127_733488_10 Gluconate 2-dehydrogenase subunit 3 - - - 0.000000000000000000000000000000000000000000000000000000004788 208.0
TLS2_k127_733488_11 FeoA K04758 - - 0.0000000000000000000317 96.0
TLS2_k127_733488_2 glycosyl transferase family K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 2.536e-242 772.0
TLS2_k127_733488_3 PFAM NADH flavin oxidoreductase NADH oxidase - - - 4.112e-194 616.0
TLS2_k127_733488_4 Glycosyl Hydrolase Family 88 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 605.0
TLS2_k127_733488_5 transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 495.0
TLS2_k127_733488_6 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 332.0
TLS2_k127_733488_7 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000094 283.0
TLS2_k127_733488_8 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.0000000000000000000000000000000000000000000000000000000000000000008344 240.0
TLS2_k127_733488_9 PFAM SMP-30 Gluconolaconase LRE-like region K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000001156 237.0
TLS2_k127_7412835_0 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 312.0
TLS2_k127_7412835_1 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 288.0
TLS2_k127_7417977_0 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001362 254.0
TLS2_k127_7417977_1 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000000000007813 207.0
TLS2_k127_7417977_2 spore germination - - - 0.000000000000000000000000000000000000000000000001128 191.0
TLS2_k127_7417977_3 ATP hydrolysis coupled proton transport K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000004825 72.0
TLS2_k127_7446515_0 Alpha-L-arabinofuranosidase K01209 - 3.2.1.55 1.495e-215 677.0
TLS2_k127_7446515_1 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 619.0
TLS2_k127_7446515_2 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000008202 241.0
TLS2_k127_7446515_3 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07776 - - 0.00001351 53.0
TLS2_k127_7452192_0 PQQ-like domain K00117 - 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 592.0
TLS2_k127_7452192_1 Peptidase dimerisation domain K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 489.0
TLS2_k127_755139_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 492.0
TLS2_k127_755139_1 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000278 467.0
TLS2_k127_755139_2 mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 425.0
TLS2_k127_755139_3 myo-inosose-2 dehydratase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009582 415.0
TLS2_k127_755139_4 Belongs to the LDH MDH superfamily K00016 - 1.1.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 362.0
TLS2_k127_755139_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000736 213.0
TLS2_k127_755139_6 MerR, DNA binding K19591 - - 0.000000000000000000000000000000000000000000004935 175.0
TLS2_k127_755139_7 - - - - 0.000000000000000000000000000000000001393 151.0
TLS2_k127_755139_8 lactoylglutathione lyase activity K08234 - - 0.000000000000000000000000000005162 136.0
TLS2_k127_755139_9 - - - - 0.00000000000000000000000001046 121.0
TLS2_k127_76225_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000008225 248.0
TLS2_k127_76225_1 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.000004417 56.0
TLS2_k127_783911_0 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004309 342.0
TLS2_k127_783911_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989,K02428 - 2.7.7.56,3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 315.0
TLS2_k127_783911_10 Sporulation and spore germination - - - 0.0000000000000000000515 104.0
TLS2_k127_783911_2 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003977 293.0
TLS2_k127_783911_3 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000006214 251.0
TLS2_k127_783911_4 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001134 259.0
TLS2_k127_783911_5 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000006451 241.0
TLS2_k127_783911_6 membrane - - - 0.000000000000000000000000000000000000000000003618 175.0
TLS2_k127_783911_7 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000008422 175.0
TLS2_k127_783911_8 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000001376 153.0
TLS2_k127_783911_9 Belongs to the Glu Leu Phe Val dehydrogenases family K00262 - 1.4.1.4 0.0000000000000000000000000000000007061 131.0
TLS2_k127_816264_0 PFAM Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000256 259.0
TLS2_k127_816264_1 Nad-dependent epimerase dehydratase K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000002294 193.0
TLS2_k127_816264_2 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000005493 78.0
TLS2_k127_846718_0 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009148 500.0
TLS2_k127_85288_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.749e-222 728.0
TLS2_k127_85288_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 2.486e-211 673.0
TLS2_k127_85288_10 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000000002606 112.0
TLS2_k127_85288_11 Protein of unknown function (DUF503) K09764 - - 0.0000000000003615 72.0
TLS2_k127_85288_2 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005242 488.0
TLS2_k127_85288_3 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 391.0
TLS2_k127_85288_4 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 323.0
TLS2_k127_85288_5 DHH family K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000767 255.0
TLS2_k127_85288_6 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000004225 240.0
TLS2_k127_85288_7 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000001049 178.0
TLS2_k127_85288_8 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000009892 141.0
TLS2_k127_85288_9 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000008225 117.0
TLS2_k127_875252_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 559.0
TLS2_k127_875252_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 401.0
TLS2_k127_875252_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 321.0
TLS2_k127_875252_3 PQQ-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 312.0
TLS2_k127_875252_4 Belongs to the ClpA ClpB family K03696 - - 0.00000000000000000000003253 110.0
TLS2_k127_875252_5 Sulphur transport K07112 - - 0.000000000000000000001802 95.0
TLS2_k127_875252_6 Protein of unknown function (DUF3311) - - - 0.00000009027 63.0
TLS2_k127_909173_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 482.0
TLS2_k127_909173_1 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008996 469.0
TLS2_k127_909173_2 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000000000000001796 216.0
TLS2_k127_909173_3 dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000034 216.0
TLS2_k127_909173_4 C4-type zinc ribbon domain K07164 - - 0.00000000000000000000000000000003061 136.0
TLS2_k127_936450_0 Dienelactone hydrolase family - - - 7.263e-231 734.0
TLS2_k127_936450_1 lysine biosynthetic process via aminoadipic acid - - - 4.479e-205 668.0
TLS2_k127_936450_10 Allophanate hydrolase subunit 2 K01457 - 3.5.1.54 0.00000000000000000000000000000000000000000000000000000000000562 220.0
TLS2_k127_936450_11 Pfam:AHS1 - - - 0.00000000000000000000000000000000000000000000000000000961 207.0
TLS2_k127_936450_12 cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000004036 198.0
TLS2_k127_936450_13 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000005831 138.0
TLS2_k127_936450_14 Transglycosylase associated protein - - - 0.000000000000000000000000000685 114.0
TLS2_k127_936450_15 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.0000000000000000000000000626 116.0
TLS2_k127_936450_16 efflux transmembrane transporter activity K02004 - - 0.00000000000000000007335 93.0
TLS2_k127_936450_2 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 6.442e-205 649.0
TLS2_k127_936450_3 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005576 602.0
TLS2_k127_936450_4 PfkB domain protein K00874 - 2.7.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 566.0
TLS2_k127_936450_5 Bacterial protein of unknown function (DUF839) K07093 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 431.0
TLS2_k127_936450_6 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 403.0
TLS2_k127_936450_7 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 342.0
TLS2_k127_936450_8 Type ii and iii secretion system protein K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008816 334.0
TLS2_k127_936450_9 Helix-hairpin-helix domain K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 319.0
TLS2_k127_940415_0 Sodium:solute symporter family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 388.0
TLS2_k127_940415_1 Neutral/alkaline non-lysosomal ceramidase, N-terminal - - - 0.0000000000000000000000005894 117.0
TLS2_k127_944724_0 efflux transmembrane transporter activity - - - 6.599e-305 958.0
TLS2_k127_944724_1 PFAM Acetyl xylan esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 537.0
TLS2_k127_944724_10 Response regulator, receiver - - - 0.00000000000000000000000000000000002393 146.0
TLS2_k127_944724_11 Serine aminopeptidase, S33 K00433 - 1.11.1.10 0.000000000000000000000000000004492 119.0
TLS2_k127_944724_12 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000002575 101.0
TLS2_k127_944724_14 Beta-lactamase - - - 0.000000003084 68.0
TLS2_k127_944724_2 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 503.0
TLS2_k127_944724_3 C-terminal region of aryl-sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 490.0
TLS2_k127_944724_4 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000898 508.0
TLS2_k127_944724_5 protein histidine kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 414.0
TLS2_k127_944724_6 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007358 418.0
TLS2_k127_944724_7 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 362.0
TLS2_k127_944724_8 G/U mismatch-specific uracil-DNA glycosylase activity K01934,K03649 GO:0000700,GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008263,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.28,6.3.3.2 0.000000000000000000000000000000000000000000000004889 185.0
TLS2_k127_944724_9 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000001957 145.0
TLS2_k127_947916_0 Heavy metal translocating P-type atpase K01534 - 3.6.3.3,3.6.3.5 3.874e-196 639.0
TLS2_k127_947916_1 KaiC K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 602.0
TLS2_k127_947916_10 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 297.0
TLS2_k127_947916_11 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 310.0
TLS2_k127_947916_12 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000009281 263.0
TLS2_k127_947916_13 PFAM asparagine synthase K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001999 263.0
TLS2_k127_947916_14 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000002145 270.0
TLS2_k127_947916_15 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000001277 247.0
TLS2_k127_947916_16 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000004253 226.0
TLS2_k127_947916_17 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000003025 217.0
TLS2_k127_947916_18 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.0000000000000000000000000000000000000000000001973 179.0
TLS2_k127_947916_19 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000008176 168.0
TLS2_k127_947916_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003935 462.0
TLS2_k127_947916_20 OmpA family K03640 - - 0.00000000000000000000000000000000004359 141.0
TLS2_k127_947916_21 PFAM regulatory protein ArsR K21903 - - 0.000000000000000000000000000000203 128.0
TLS2_k127_947916_22 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000005333 137.0
TLS2_k127_947916_23 Domain of unknown function (DUF4340) - - - 0.00000000000000000000000000002301 133.0
TLS2_k127_947916_24 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000003356 86.0
TLS2_k127_947916_25 - K05826 - - 0.00000002019 59.0
TLS2_k127_947916_26 - - - - 0.0000005211 57.0
TLS2_k127_947916_27 response regulator - - - 0.00001111 56.0
TLS2_k127_947916_28 arsenate reductase (glutaredoxin) activity K00537,K04069,K05521,K16509 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1,1.97.1.4,3.2.2.24 0.00002609 49.0
TLS2_k127_947916_3 peptidase S45, penicillin amidase K01434 - 3.5.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 471.0
TLS2_k127_947916_4 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 400.0
TLS2_k127_947916_5 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004341 373.0
TLS2_k127_947916_6 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 365.0
TLS2_k127_947916_7 Catalyzes the conversion of dihydroorotate to orotate K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 350.0
TLS2_k127_947916_8 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 359.0
TLS2_k127_947916_9 ABC-type uncharacterized transport system K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 342.0
TLS2_k127_949358_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001904 290.0
TLS2_k127_949696_0 Glycosyl hydrolases family 2 - - - 9.666e-316 998.0
TLS2_k127_949696_1 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009159 557.0
TLS2_k127_949696_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.000000000000000000000001185 116.0
TLS2_k127_949696_11 bacterial OsmY and nodulation domain K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.00001428 58.0
TLS2_k127_949696_2 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 508.0
TLS2_k127_949696_3 Dynamin family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004083 507.0
TLS2_k127_949696_4 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 319.0
TLS2_k127_949696_5 PFAM Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005543 275.0
TLS2_k127_949696_6 Helix-hairpin-helix domain K04477 - - 0.000000000000000000000000000000000000000000000000000004847 206.0
TLS2_k127_949696_7 mannose-ethanolamine phosphotransferase activity - - - 0.00000000000000000000000000000000000000000006572 169.0
TLS2_k127_949696_8 DinB family - - - 0.0000000000000000000000000000000000000001389 160.0
TLS2_k127_949696_9 Protein of unknown function (DUF2721) - - - 0.0000000000000000000000000000000008621 136.0
TLS2_k127_950677_0 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 416.0
TLS2_k127_950677_1 peptidase activity K01286 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 360.0
TLS2_k127_950677_2 carboxylic ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 332.0
TLS2_k127_950677_3 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000957 179.0
TLS2_k127_950677_4 - - - - 0.000000000000000000000004903 106.0
TLS2_k127_950677_5 - - - - 0.0000000000000000000001476 102.0
TLS2_k127_951019_0 COG0277 FAD FMN-containing dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 540.0
TLS2_k127_951019_1 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006878 525.0
TLS2_k127_951019_2 phosphoesterase, PA-phosphatase related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003893 496.0
TLS2_k127_951019_3 Subtilase family K17734 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 349.0
TLS2_k127_951019_4 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000001472 198.0
TLS2_k127_958555_0 Belongs to the sigma-70 factor family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000408 528.0
TLS2_k127_958555_1 beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 511.0
TLS2_k127_958555_10 Cupin domain - - - 0.00000000000000000000000000000000005323 138.0
TLS2_k127_958555_11 protein containing a von Willebrand factor type A (vWA) domain K07114 - - 0.0000000000000000000000000000002633 136.0
TLS2_k127_958555_12 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.000000000000000000000000000001611 128.0
TLS2_k127_958555_13 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000006641 114.0
TLS2_k127_958555_14 Belongs to the glycosyl hydrolase 26 family - - - 0.00000000000000000005308 106.0
TLS2_k127_958555_15 - - - - 0.000000000000000007197 91.0
TLS2_k127_958555_16 PFAM lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0002695 52.0
TLS2_k127_958555_17 Phosphopantetheine attachment site K02078 - - 0.0009532 50.0
TLS2_k127_958555_2 PFAM Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 488.0
TLS2_k127_958555_3 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 369.0
TLS2_k127_958555_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 299.0
TLS2_k127_958555_5 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 311.0
TLS2_k127_958555_6 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000001272 273.0
TLS2_k127_958555_7 ABC transporter transmembrane region - - - 0.000000000000000000000000000000000000000000000000000007113 216.0
TLS2_k127_958555_8 YCII-related domain - - - 0.00000000000000000000000000000000000000000005368 164.0
TLS2_k127_958555_9 - - - - 0.000000000000000000000000000000000000000001107 160.0
TLS2_k127_967536_0 4Fe-4S dicluster domain K00184 - - 0.0 1133.0
TLS2_k127_967536_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.853e-266 829.0
TLS2_k127_967536_10 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 376.0
TLS2_k127_967536_11 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 354.0
TLS2_k127_967536_12 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004862 312.0
TLS2_k127_967536_13 protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002769 285.0
TLS2_k127_967536_14 PFAM cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000001593 229.0
TLS2_k127_967536_15 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000000000000000000000000000000000000269 224.0
TLS2_k127_967536_16 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000004285 224.0
TLS2_k127_967536_17 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000003876 217.0
TLS2_k127_967536_18 Thioredoxin domain - - - 0.000000000000000000000000007331 117.0
TLS2_k127_967536_19 TIGRFAM Caa(3)-type oxidase, subunit IV K02277 - 1.9.3.1 0.0000000000000000000003934 100.0
TLS2_k127_967536_2 Polysulphide reductase, NrfD K00185 - - 4.87e-204 644.0
TLS2_k127_967536_20 Thioredoxin domain - - - 0.00000000000000233 77.0
TLS2_k127_967536_21 - - - - 0.000000000004026 74.0
TLS2_k127_967536_3 M61 glycyl aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 477.0
TLS2_k127_967536_4 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 469.0
TLS2_k127_967536_5 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 447.0
TLS2_k127_967536_6 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 447.0
TLS2_k127_967536_7 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 446.0
TLS2_k127_967536_8 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 424.0
TLS2_k127_967536_9 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 386.0
TLS2_k127_971803_0 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005709 435.0
TLS2_k127_971803_1 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000003402 257.0
TLS2_k127_971803_2 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000015 204.0
TLS2_k127_971803_3 galactose-6-phosphate isomerase activity K00568,K01808 - 2.1.1.222,2.1.1.64,5.3.1.6 0.00000000000000000000000000000003192 133.0
TLS2_k127_971803_4 uracil phosphoribosyltransferase K00761 - 2.4.2.9 0.0000000003156 66.0
TLS2_k127_973372_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 517.0
TLS2_k127_973372_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008468 418.0
TLS2_k127_973372_10 Tetratricopeptide repeat - - - 0.000000000000000000000000005546 120.0
TLS2_k127_973372_11 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028,K08697 - - 0.000000000000000000000000006288 111.0
TLS2_k127_973372_12 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 - - 0.0000000000000000002912 89.0
TLS2_k127_973372_13 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - 0.0000000000000000008654 88.0
TLS2_k127_973372_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002922 336.0
TLS2_k127_973372_3 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001166 276.0
TLS2_k127_973372_4 Pterin binding enzyme K00796,K13941 - 2.5.1.15,2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000000002225 255.0
TLS2_k127_973372_5 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001595 248.0
TLS2_k127_973372_6 PFAM Class II aldolase adducin K01628 - 4.1.2.17 0.00000000000000000000000000000000000000000000000000000000000000000001763 247.0
TLS2_k127_973372_7 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K01142,K10773 GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2,4.2.99.18 0.00000000000000000000000000000000000000000000000000000001379 209.0
TLS2_k127_973372_8 ethanolamine catabolic process K04027 - - 0.000000000000000000000000000000000000009912 147.0
TLS2_k127_973372_9 YbbR-like protein - - - 0.0000000000000000000000000000000004411 143.0
TLS2_k127_981511_0 ABC transporter K15738 - - 8.541e-282 878.0
TLS2_k127_981511_1 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 1.379e-239 755.0
TLS2_k127_981511_10 Laminin G domain - - - 0.00000000000001292 88.0
TLS2_k127_981511_11 Protein of unknown function (DUF533) - - - 0.000000000002577 78.0
TLS2_k127_981511_2 IgA Peptidase M64 - - - 1.479e-205 657.0
TLS2_k127_981511_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 488.0
TLS2_k127_981511_4 N-methylhydantoinase A acetone carboxylase, beta subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 475.0
TLS2_k127_981511_5 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003204 392.0
TLS2_k127_981511_6 HI0933-like protein K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003753 327.0
TLS2_k127_981511_7 EVE domain - - - 0.00000000000000000000000000000000000000000000000000000003882 200.0
TLS2_k127_981511_8 ApaG domain K06195 - - 0.000000000000000000000000000000000000000000000002011 176.0
TLS2_k127_981511_9 Histidinol-phosphate aromatic aminotransferase and cobyric acid decarboxylase K00817 - 2.6.1.9 0.00000000000000000000000000005466 117.0
TLS2_k127_981849_0 alcohol dehydrogenase K00001 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 584.0
TLS2_k127_981849_1 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 509.0
TLS2_k127_981849_2 Coenzyme A transferase K01026 - 2.8.3.1 0.0000000000000000000003952 98.0
TLS2_k127_984388_0 ABC transporter transmembrane region K11085 - - 1.306e-242 765.0
TLS2_k127_984388_1 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 305.0
TLS2_k127_984388_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000008204 255.0
TLS2_k127_984388_3 histidine-tRNA ligase activity K01892,K02502 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000001873 202.0
TLS2_k127_984388_4 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000000000000007954 179.0
TLS2_k127_984388_5 PFAM transposase mutator type - - - 0.000000000000000000000000000000000000000000000105 173.0
TLS2_k127_984388_6 23S rRNA-intervening sequence protein - - - 0.000000000000000000001054 99.0
TLS2_k127_984388_7 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000004632 95.0
TLS2_k127_984388_8 Pfam:DUF162 K00782 - - 0.00000000005594 63.0
TLS2_k127_984388_9 PD-(D/E)XK nuclease superfamily - - - 0.000002346 54.0
TLS2_k127_995931_0 Domain of unknown function (DUF362) - - - 4.666e-196 615.0
TLS2_k127_995931_1 DnaJ molecular chaperone homology domain - - - 0.00000000000000000000000000000000000003761 150.0
TLS2_k127_995931_2 Protein kinase domain - - - 0.0006152 53.0
TLS2_k127_999604_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.228e-225 717.0