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Overview

ID MAG03990
Name TLS2_bin.22
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Actinomycetota
Class Acidimicrobiia
Order UBA5794
Family ZC4RG35
Genus JAOUGY01
Species
Assembly information
Completeness (%) 88.03
Contamination (%) 0.84
GC content (%) 71.0
N50 (bp) 34,069
Genome size (bp) 3,472,381

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3116

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1105494_0 ABC-type dipeptide transport system, periplasmic component K02035 - - 8.074e-240 758.0
TLS2_k127_1105494_1 xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 6.401e-195 642.0
TLS2_k127_1105494_10 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000001845 238.0
TLS2_k127_1105494_11 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000002231 218.0
TLS2_k127_1105494_12 Putative peptidoglycan binding domain - - - 0.0000000000000000000000000000000000000000000000000000009666 206.0
TLS2_k127_1105494_13 Prephenate dehydratase K04518,K14170,K14187 - 1.3.1.12,4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000002205 183.0
TLS2_k127_1105494_14 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000005331 115.0
TLS2_k127_1105494_15 Rhodanese Homology Domain - - - 0.000000000000000000000001825 107.0
TLS2_k127_1105494_16 D-alanyl-D-alanine carboxypeptidase - - - 0.0000000000000000006429 102.0
TLS2_k127_1105494_17 translation release factor activity - - - 0.00000000000000003974 94.0
TLS2_k127_1105494_19 - - - - 0.00000000005509 71.0
TLS2_k127_1105494_2 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 465.0
TLS2_k127_1105494_20 Domain of unknown function (DUF2017) - - - 0.0000003456 61.0
TLS2_k127_1105494_21 bacterial-type flagellum organization - - - 0.0000009123 60.0
TLS2_k127_1105494_3 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003747 394.0
TLS2_k127_1105494_4 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009459 375.0
TLS2_k127_1105494_5 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009344 359.0
TLS2_k127_1105494_6 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005037 289.0
TLS2_k127_1105494_7 Protein containing von Willebrand factor type A (vWA) domain K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004703 286.0
TLS2_k127_1105494_8 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001019 282.0
TLS2_k127_1105494_9 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000003787 262.0
TLS2_k127_1123682_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0 1608.0
TLS2_k127_1123682_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0 1136.0
TLS2_k127_1123682_10 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 443.0
TLS2_k127_1123682_11 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 441.0
TLS2_k127_1123682_12 Belongs to the RimK family K05827,K05844 - 6.3.2.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 419.0
TLS2_k127_1123682_13 Na+/H+ antiporter 1 K03313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008582 369.0
TLS2_k127_1123682_14 mandelate racemase muconate lactonizing K19802 GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855 5.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 361.0
TLS2_k127_1123682_15 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 344.0
TLS2_k127_1123682_16 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005573 349.0
TLS2_k127_1123682_17 succinylglutamate desuccinylase aspartoacylase K06987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009216 346.0
TLS2_k127_1123682_18 branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00824 - 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006852 345.0
TLS2_k127_1123682_19 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 334.0
TLS2_k127_1123682_2 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 - 3.4.21.83 7.882e-225 718.0
TLS2_k127_1123682_20 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 330.0
TLS2_k127_1123682_21 Peptidase dimerisation domain K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 322.0
TLS2_k127_1123682_22 PFAM YibE F-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 299.0
TLS2_k127_1123682_23 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures K07503 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009726 306.0
TLS2_k127_1123682_24 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000001294 248.0
TLS2_k127_1123682_25 protein related to plant photosystem II stability assembly factor - - - 0.00000000000000000000000000000000000000000000000000000000000000006688 239.0
TLS2_k127_1123682_26 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000007998 245.0
TLS2_k127_1123682_27 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 0.0000000000000000000000000000000000000000000000000000000003743 210.0
TLS2_k127_1123682_28 methyltransferase K13311,K13326,K21335 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0046983 2.1.1.234 0.0000000000000000000000000000000000000000000000000003119 203.0
TLS2_k127_1123682_29 Putative ATP-dependant zinc protease - - - 0.00000000000000000000000000000000000000000000000001795 185.0
TLS2_k127_1123682_3 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 582.0
TLS2_k127_1123682_30 CoA binding domain - - - 0.000000000000000000000000000000000000000000000001832 200.0
TLS2_k127_1123682_31 protein conserved in bacteria K09966 - - 0.000000000000000000000000000000000000000000000002855 182.0
TLS2_k127_1123682_32 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000003074 126.0
TLS2_k127_1123682_33 GDP-mannose mannosyl hydrolase activity K03574 - 3.6.1.55 0.0000000000000000000000001418 119.0
TLS2_k127_1123682_34 NUDIX domain K03574 - 3.6.1.55 0.00000000000000000003784 95.0
TLS2_k127_1123682_35 ArsR family transcriptional regulator - - - 0.00000000000000000003882 102.0
TLS2_k127_1123682_36 Protein of unknown function (DUF2905) - - - 0.000000000001161 73.0
TLS2_k127_1123682_37 Transcription factor WhiB - - - 0.000000000001551 72.0
TLS2_k127_1123682_38 Protein of unknown function (DUF454) K09790 - - 0.000000000007869 71.0
TLS2_k127_1123682_39 Mo-molybdopterin cofactor metabolic process K03636 - - 0.0000002986 63.0
TLS2_k127_1123682_4 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 564.0
TLS2_k127_1123682_40 - - - - 0.00002012 58.0
TLS2_k127_1123682_5 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007191 510.0
TLS2_k127_1123682_6 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 487.0
TLS2_k127_1123682_7 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002775 471.0
TLS2_k127_1123682_8 Fructose-bisphosphate aldolase, class II K01624 GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009338 460.0
TLS2_k127_1123682_9 Thi4 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 477.0
TLS2_k127_1138725_0 ATP-dependent helicase K03578 - 3.6.4.13 0.0 1292.0
TLS2_k127_1138725_1 DegT/DnrJ/EryC1/StrS aminotransferase family - GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 447.0
TLS2_k127_1138725_10 L-asparaginase II - - - 0.0000000000000000000000000000000000000000000000000000000004781 213.0
TLS2_k127_1138725_11 heme binding K21471,K21472 - - 0.00000000000000000000000000000000002642 151.0
TLS2_k127_1138725_12 DoxX - - - 0.00000000000000000000000000000000006494 140.0
TLS2_k127_1138725_13 - - - - 0.00000000000000000000000007313 116.0
TLS2_k127_1138725_14 Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA K06947 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000000000008485 109.0
TLS2_k127_1138725_15 Mo-molybdopterin cofactor metabolic process K03636,K21142 - 2.8.1.12 0.0000000000000112 85.0
TLS2_k127_1138725_16 Putative bacterial sensory transduction regulator - - - 0.0000000000003659 79.0
TLS2_k127_1138725_17 redox protein regulator of disulfide bond formation - - - 0.00000000003637 68.0
TLS2_k127_1138725_18 Glutaredoxin-like domain (DUF836) - - - 0.0000000003696 65.0
TLS2_k127_1138725_19 Acetyltransferase (GNAT) domain - - - 0.00000001685 65.0
TLS2_k127_1138725_2 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 434.0
TLS2_k127_1138725_3 NhaP-type Na H and K H - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 430.0
TLS2_k127_1138725_4 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 374.0
TLS2_k127_1138725_5 Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway K15521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 2.4.1.250 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 357.0
TLS2_k127_1138725_6 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 343.0
TLS2_k127_1138725_7 nitric oxide dioxygenase activity K00528,K05784 GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 310.0
TLS2_k127_1138725_8 Oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000002853 243.0
TLS2_k127_1138725_9 transferase activity, transferring alkyl or aryl (other than methyl) groups K22205 - - 0.00000000000000000000000000000000000000000000000000000000002363 229.0
TLS2_k127_1177450_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007665 475.0
TLS2_k127_1177450_1 ABC-type molybdenum transport system ATPase component photorepair protein PhrA K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000002773 260.0
TLS2_k127_1371824_0 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 502.0
TLS2_k127_1371824_1 UDP binding domain K13015 - 1.1.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004891 356.0
TLS2_k127_1371824_2 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001201 246.0
TLS2_k127_1371824_3 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002266 246.0
TLS2_k127_1371824_4 Universal stress protein - - - 0.000000000000008309 80.0
TLS2_k127_1371824_5 - - - - 0.000000492 59.0
TLS2_k127_1488043_0 Hydrolase CocE NonD family K06978 - - 2.742e-292 909.0
TLS2_k127_1488043_1 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 531.0
TLS2_k127_1488043_10 SMP-30/Gluconolaconase/LRE-like region - - - 0.00000000000000000000000000000000000000000000000000000000000000000001975 244.0
TLS2_k127_1488043_11 PHP domain protein K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000000002794 231.0
TLS2_k127_1488043_12 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000322 224.0
TLS2_k127_1488043_13 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000004883 209.0
TLS2_k127_1488043_14 EVE domain - - - 0.0000000000000000000000000000000000000000000000000000000004311 205.0
TLS2_k127_1488043_15 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000000000000000000001337 202.0
TLS2_k127_1488043_16 PFAM Haloacid dehalogenase domain protein hydrolase - - - 0.000000000000000000000000000000000000000000000000000002939 203.0
TLS2_k127_1488043_17 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000001345 197.0
TLS2_k127_1488043_18 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000003286 189.0
TLS2_k127_1488043_19 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000007156 190.0
TLS2_k127_1488043_2 Abc transporter K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 451.0
TLS2_k127_1488043_20 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000002406 174.0
TLS2_k127_1488043_21 3-demethylubiquinone-9 3-O-methyltransferase activity K03428 - 2.1.1.11 0.000000000000000000000000000000000000000002318 163.0
TLS2_k127_1488043_22 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000000000000000000000000004274 155.0
TLS2_k127_1488043_23 PRC-barrel domain - - - 0.00000000000000000000000000000000005338 139.0
TLS2_k127_1488043_24 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000001229 105.0
TLS2_k127_1488043_25 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.00000000000000000000002393 102.0
TLS2_k127_1488043_26 - - - - 0.0000000000000000000009046 103.0
TLS2_k127_1488043_27 Membrane-bound serine protease (ClpP class) K07403 - - 0.00000000000000000001407 106.0
TLS2_k127_1488043_28 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - - 0.000000000000000333 93.0
TLS2_k127_1488043_29 Peptidase family M50 - - - 0.000000000000008833 88.0
TLS2_k127_1488043_3 ACT domain K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 466.0
TLS2_k127_1488043_30 phosphorelay signal transduction system - - - 0.0000000000002669 75.0
TLS2_k127_1488043_31 basic membrane K07335 - - 0.000000000003495 79.0
TLS2_k127_1488043_4 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 424.0
TLS2_k127_1488043_5 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 409.0
TLS2_k127_1488043_6 Branched-chain amino acid aminotransferase K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 369.0
TLS2_k127_1488043_7 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005746 339.0
TLS2_k127_1488043_8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008784 317.0
TLS2_k127_1488043_9 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003783 278.0
TLS2_k127_1544578_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 2.149e-251 789.0
TLS2_k127_1544578_1 Aminotransferase class-V - - - 9.367e-234 736.0
TLS2_k127_1544578_10 Peptidase dimerisation domain K13049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006639 336.0
TLS2_k127_1544578_11 Protein of unknown function (DUF445) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006563 321.0
TLS2_k127_1544578_12 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 319.0
TLS2_k127_1544578_13 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 289.0
TLS2_k127_1544578_14 N,N-dimethylaniline monooxygenase activity K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003979 280.0
TLS2_k127_1544578_15 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004757 283.0
TLS2_k127_1544578_16 Conserved hypothetical protein (DUF2461) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005229 259.0
TLS2_k127_1544578_17 Protein of unknown function DUF58 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000436 257.0
TLS2_k127_1544578_18 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002065 248.0
TLS2_k127_1544578_19 Thioesterase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001662 248.0
TLS2_k127_1544578_2 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 1.616e-226 722.0
TLS2_k127_1544578_21 PFAM 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000001909 237.0
TLS2_k127_1544578_22 von Willebrand factor type A domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000003914 224.0
TLS2_k127_1544578_23 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000002405 214.0
TLS2_k127_1544578_24 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000001679 218.0
TLS2_k127_1544578_25 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000001481 206.0
TLS2_k127_1544578_26 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000003574 193.0
TLS2_k127_1544578_27 May play a role in the intracellular transport of hydrophobic ligands - - - 0.000000000000000000000000000000000000000000000003284 186.0
TLS2_k127_1544578_28 Belongs to the ABC transporter superfamily K10112 - - 0.000000000000000000000000000000000000000000006263 177.0
TLS2_k127_1544578_29 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000008066 160.0
TLS2_k127_1544578_3 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 2.792e-207 662.0
TLS2_k127_1544578_30 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000005458 154.0
TLS2_k127_1544578_31 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000003012 143.0
TLS2_k127_1544578_32 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000002183 141.0
TLS2_k127_1544578_33 PFAM Ribonuclease BN-like family K07058 - - 0.000000000000000000000007836 115.0
TLS2_k127_1544578_34 Belongs to the peptidase S8 family - - - 0.000000000000000000000357 111.0
TLS2_k127_1544578_35 TIGRFAM YihY family protein (not ribonuclease BN) K07058 - - 0.0000000000000000000008368 106.0
TLS2_k127_1544578_36 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000006128 102.0
TLS2_k127_1544578_37 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000005004 91.0
TLS2_k127_1544578_38 PspC domain - - - 0.00000000000003289 79.0
TLS2_k127_1544578_39 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.000000000008689 78.0
TLS2_k127_1544578_4 ABC transporter transmembrane region K02021,K06147,K16786,K16787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 605.0
TLS2_k127_1544578_40 Membrane - - - 0.0000000004229 69.0
TLS2_k127_1544578_5 ABC transporter transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 559.0
TLS2_k127_1544578_6 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 510.0
TLS2_k127_1544578_7 associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 374.0
TLS2_k127_1544578_8 ATP dependent DNA ligase domain - GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 338.0
TLS2_k127_1544578_9 DNA primase, small subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 338.0
TLS2_k127_161957_0 Carboxyl transferase domain - - - 6.768e-226 713.0
TLS2_k127_161957_1 Acetyl propionyl-CoA carboxylase, alpha subunit K01965,K01968 - 6.4.1.3,6.4.1.4 1.229e-224 713.0
TLS2_k127_161957_10 PFAM Wyosine base formation - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000001681 247.0
TLS2_k127_161957_11 reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000002107 211.0
TLS2_k127_161957_12 MaoC like domain - - - 0.00000000000000000000000000000000000000000003628 166.0
TLS2_k127_161957_13 transduction histidine kinase - - - 0.00000000000000000000002349 115.0
TLS2_k127_161957_14 Belongs to the universal stress protein A family - - - 0.00000000000000000000004341 107.0
TLS2_k127_161957_15 - - - - 0.00000000000000000000566 107.0
TLS2_k127_161957_16 - - - - 0.00000000006132 72.0
TLS2_k127_161957_18 acetyltransferase - - - 0.0002994 52.0
TLS2_k127_161957_2 ATPases associated with a variety of cellular activities K05847 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 505.0
TLS2_k127_161957_3 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005921 427.0
TLS2_k127_161957_4 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 381.0
TLS2_k127_161957_5 Substrate binding domain of ABC-type glycine betaine transport system K05845 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004295 379.0
TLS2_k127_161957_6 Binding-protein-dependent transport system inner membrane component K05845,K05846 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000158 278.0
TLS2_k127_161957_7 Binding-protein-dependent transport system inner membrane component K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001218 263.0
TLS2_k127_161957_8 Short-chain dehydrogenase reductase sdr - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001068 275.0
TLS2_k127_161957_9 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058,K16843 - 1.1.1.310,1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000004859 275.0
TLS2_k127_1687785_0 glutamate-1-semialdehyde 2,1-aminomutase activity K01845,K07257 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003985 507.0
TLS2_k127_1687785_1 PFAM N-acetylneuraminic acid synthase K01654 - 2.5.1.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 440.0
TLS2_k127_1687785_2 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 387.0
TLS2_k127_1687785_3 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 326.0
TLS2_k127_1687785_4 Transketolase, pyrimidine binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002177 289.0
TLS2_k127_1687785_5 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000001107 228.0
TLS2_k127_1687785_6 haloacid dehalogenase-like hydrolase K03270,K21055,K21749 GO:0003674,GO:0003824,GO:0008781,GO:0016740,GO:0016772,GO:0016779,GO:0070567 2.7.7.43,2.7.7.92,3.1.3.103,3.1.3.45 0.00000000000000000000000000000000000000000000000004152 184.0
TLS2_k127_1687785_7 dioxygenase activity - - - 0.000000000000000000000000000000000000000000000000221 188.0
TLS2_k127_1687785_8 Cytidylyltransferase - - - 0.00000000000000000000000000000000000000002704 156.0
TLS2_k127_1790859_0 PFAM Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 608.0
TLS2_k127_1790859_1 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 468.0
TLS2_k127_1790859_2 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 418.0
TLS2_k127_1790859_3 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000000000000000009155 213.0
TLS2_k127_1790859_4 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000131 166.0
TLS2_k127_1790859_5 SMART protein phosphatase 2C domain protein - - - 0.0000000000000000002814 93.0
TLS2_k127_1790859_6 Cupin 2, conserved barrel domain protein K11477 - - 0.0000006857 53.0
TLS2_k127_1801893_0 Heavy metal translocating P-type atpase K01533,K17686 - 3.6.3.4,3.6.3.54 0.0 1206.0
TLS2_k127_1801893_1 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009149 620.0
TLS2_k127_1801893_10 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 412.0
TLS2_k127_1801893_11 NADH ubiquinone oxidoreductase, 20 Kd subunit K18007 - 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 396.0
TLS2_k127_1801893_12 Pfam Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004484 402.0
TLS2_k127_1801893_13 DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 398.0
TLS2_k127_1801893_14 DNA ligase D DNA polymerase LigD K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004083 397.0
TLS2_k127_1801893_15 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009388 399.0
TLS2_k127_1801893_16 Nitrile hydratase, alpha chain K01721 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 375.0
TLS2_k127_1801893_17 beta-1,4-mannooligosaccharide phosphorylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009931 379.0
TLS2_k127_1801893_18 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000459 364.0
TLS2_k127_1801893_19 COG2230 Cyclopropane fatty acid synthase and related methyltransferases K00574 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0008825,GO:0009987,GO:0016740,GO:0016741,GO:0030258,GO:0032259,GO:0044237,GO:0044238,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 363.0
TLS2_k127_1801893_2 Nickel-dependent hydrogenase K00436 - 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008612 584.0
TLS2_k127_1801893_20 Thiamine pyrophosphate enzyme, central domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 364.0
TLS2_k127_1801893_21 Alpha/beta hydrolase of unknown function (DUF1100) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 334.0
TLS2_k127_1801893_22 CHAT domain K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 344.0
TLS2_k127_1801893_23 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 322.0
TLS2_k127_1801893_24 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003961 324.0
TLS2_k127_1801893_25 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002006 283.0
TLS2_k127_1801893_26 Protein of unknown function (DUF1365) K09701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003617 297.0
TLS2_k127_1801893_27 DNA polymerase beta thumb K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000188 277.0
TLS2_k127_1801893_28 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002484 273.0
TLS2_k127_1801893_29 Serine hydrolase (FSH1) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001434 254.0
TLS2_k127_1801893_3 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 585.0
TLS2_k127_1801893_30 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000008703 259.0
TLS2_k127_1801893_31 Belongs to the carbohydrate kinase PfkB family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002683 254.0
TLS2_k127_1801893_32 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000333 233.0
TLS2_k127_1801893_33 - - - - 0.00000000000000000000000000000000000000000000000000000000118 227.0
TLS2_k127_1801893_34 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000001526 213.0
TLS2_k127_1801893_35 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000001083 205.0
TLS2_k127_1801893_36 Alpha/beta hydrolase family K06889 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136 - 0.00000000000000000000000000000000000000000000000000000005746 209.0
TLS2_k127_1801893_37 - - - - 0.00000000000000000000000000000000000000000000000000000008644 202.0
TLS2_k127_1801893_38 Low molecular weight phosphatase family - - - 0.000000000000000000000000000000000000000000000000000002864 199.0
TLS2_k127_1801893_39 - - - - 0.0000000000000000000000000000000000000000000000000002206 192.0
TLS2_k127_1801893_4 PFAM Uncharacterised protein family (UPF0182) K09118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 591.0
TLS2_k127_1801893_40 Belongs to the peptidase S16 family K07177 - - 0.0000000000000000000000000000000000000000000000000002941 197.0
TLS2_k127_1801893_41 PFAM AhpC TSA family - - - 0.000000000000000000000000000000000000000000000000002145 198.0
TLS2_k127_1801893_42 domain, Protein K07228 - - 0.000000000000000000000000000000000000000000000003493 182.0
TLS2_k127_1801893_43 Protein tyrosine kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0040007,GO:0042304,GO:0043085,GO:0043086,GO:0043170,GO:0043388,GO:0043412,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0051055,GO:0051098,GO:0051099,GO:0051101,GO:0051128,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.00000000000000000000000000000000000000000000002208 189.0
TLS2_k127_1801893_44 serine-type endopeptidase activity - - - 0.000000000000000000000000000000000000000000003672 179.0
TLS2_k127_1801893_45 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000002709 167.0
TLS2_k127_1801893_46 Belongs to the MIP aquaporin (TC 1.A.8) family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000005489 171.0
TLS2_k127_1801893_47 sequence-specific DNA binding - - - 0.00000000000000000000000000000000000000007404 168.0
TLS2_k127_1801893_48 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000000000000002323 152.0
TLS2_k127_1801893_49 BioY family K03523 - - 0.0000000000000000000000000000000000004655 161.0
TLS2_k127_1801893_5 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 470.0
TLS2_k127_1801893_50 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000004575 140.0
TLS2_k127_1801893_51 SNARE associated Golgi protein K19302 - 3.6.1.27 0.0000000000000000000000000000002088 140.0
TLS2_k127_1801893_52 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000573 124.0
TLS2_k127_1801893_53 Putative peptidoglycan binding domain - - - 0.0000000000000000000000000006799 128.0
TLS2_k127_1801893_54 DoxX K15977 - - 0.00000000000000000000000003249 114.0
TLS2_k127_1801893_55 Cupin - - - 0.0000000000000000000000001395 124.0
TLS2_k127_1801893_56 maturation K03605 - - 0.00000000000000000000002415 105.0
TLS2_k127_1801893_57 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.00000000000000000000004489 115.0
TLS2_k127_1801893_58 PFAM regulatory protein, MarR - - - 0.00000000000000000000009564 102.0
TLS2_k127_1801893_6 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 475.0
TLS2_k127_1801893_60 cheY-homologous receiver domain - - - 0.000000000000000001491 93.0
TLS2_k127_1801893_61 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.00000000000000005496 89.0
TLS2_k127_1801893_62 Heavy-metal-associated domain - - - 0.00000000002231 71.0
TLS2_k127_1801893_63 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.000000002955 68.0
TLS2_k127_1801893_64 regulation of cell shape K04074 - - 0.000000009789 69.0
TLS2_k127_1801893_7 Flavin containing amine oxidoreductase K06954 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 453.0
TLS2_k127_1801893_8 PFAM regulatory protein LuxR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008622 450.0
TLS2_k127_1801893_9 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 429.0
TLS2_k127_1852265_0 ATPase P-type (Transporting), HAD superfamily, subfamily IC - - - 0.0 1063.0
TLS2_k127_1852265_1 Domain of unknown function (DUF4397) - - - 0.0000000000000000000000000000000000000000000000005114 192.0
TLS2_k127_1852265_2 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000001303 106.0
TLS2_k127_1873096_0 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003666 568.0
TLS2_k127_1873096_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000004688 169.0
TLS2_k127_1899791_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 404.0
TLS2_k127_1899791_1 COG0433 Predicted ATPase K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005952 392.0
TLS2_k127_1899791_2 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003062 323.0
TLS2_k127_1899791_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000009967 221.0
TLS2_k127_1899791_4 Putative exonuclease SbcCD, C subunit K03546 - - 0.000000000000000000000000000000000000000000000000000000007717 219.0
TLS2_k127_1940948_0 Acyl-CoA dehydrogenase N terminal - - - 1.487e-200 653.0
TLS2_k127_1940948_1 WD40 repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008601 570.0
TLS2_k127_1940948_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005895 431.0
TLS2_k127_1940948_3 PFAM acyl-CoA dehydrogenase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 388.0
TLS2_k127_1940948_4 EamA-like transporter family K03298 - - 0.0000000000000000000000000000000000000000000000000000000003978 212.0
TLS2_k127_1940948_5 TIGRFAM 2-oxoglutarate dehydrogenase, E2 component K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000009962 187.0
TLS2_k127_1940948_6 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000006176 184.0
TLS2_k127_1940948_7 Glycosyl transferase family 8 - - - 0.000000000000000003485 94.0
TLS2_k127_1940948_8 Bacterial regulatory proteins, tetR family - - - 0.0000000000005539 77.0
TLS2_k127_1940948_9 TIGRFAM Sporulation protein YteA - - - 0.0000003484 56.0
TLS2_k127_1985672_0 UvrD-like helicase C-terminal domain K03657 GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 9.111e-230 732.0
TLS2_k127_1985672_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 3.882e-216 699.0
TLS2_k127_1985672_10 CAAX protease self-immunity - - - 0.0000006999 59.0
TLS2_k127_1985672_11 Evidence 2b Function of strongly homologous gene - - - 0.000006089 53.0
TLS2_k127_1985672_2 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009829 589.0
TLS2_k127_1985672_3 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 585.0
TLS2_k127_1985672_4 ABC transporter transmembrane region K02021,K06147,K16786,K16787 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 518.0
TLS2_k127_1985672_5 ABC transporter, transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 462.0
TLS2_k127_1985672_6 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 420.0
TLS2_k127_1985672_7 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 351.0
TLS2_k127_1985672_8 ATP-binding region, ATPase domain protein K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000005336 241.0
TLS2_k127_1985672_9 Histidine kinase - - - 0.000000000000000000000000000000000009976 147.0
TLS2_k127_2003229_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 7.231e-299 967.0
TLS2_k127_2003229_1 ABC transporter - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 3.382e-245 768.0
TLS2_k127_2003229_10 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II K01835,K01840 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 477.0
TLS2_k127_2003229_11 Pyrimidine nucleoside phosphorylase C-terminal domain K00756,K00758 GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 458.0
TLS2_k127_2003229_12 helicase superfamily c-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005953 442.0
TLS2_k127_2003229_13 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 400.0
TLS2_k127_2003229_14 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004034 402.0
TLS2_k127_2003229_15 ADP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 425.0
TLS2_k127_2003229_16 Dak1_2 K07030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 405.0
TLS2_k127_2003229_17 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 384.0
TLS2_k127_2003229_18 magnesium chelatase K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 387.0
TLS2_k127_2003229_19 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007161 360.0
TLS2_k127_2003229_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.7.8 5.199e-241 771.0
TLS2_k127_2003229_20 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 371.0
TLS2_k127_2003229_21 Binding-protein-dependent transport systems inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007856 364.0
TLS2_k127_2003229_22 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 334.0
TLS2_k127_2003229_23 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 305.0
TLS2_k127_2003229_24 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K02405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 312.0
TLS2_k127_2003229_25 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000041 302.0
TLS2_k127_2003229_26 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 319.0
TLS2_k127_2003229_27 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007725 289.0
TLS2_k127_2003229_28 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 302.0
TLS2_k127_2003229_29 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003363 288.0
TLS2_k127_2003229_3 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.15 1.686e-229 723.0
TLS2_k127_2003229_30 impB/mucB/samB family K14161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004822 291.0
TLS2_k127_2003229_31 Electron transfer flavoprotein domain K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003315 278.0
TLS2_k127_2003229_32 DHH family K06881 GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001103 281.0
TLS2_k127_2003229_33 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002414 284.0
TLS2_k127_2003229_34 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000007301 257.0
TLS2_k127_2003229_35 iron ion homeostasis K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000001338 247.0
TLS2_k127_2003229_36 Carbon-nitrogen hydrolase K11206 - - 0.00000000000000000000000000000000000000000000000000000000000000000004157 241.0
TLS2_k127_2003229_37 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000001195 235.0
TLS2_k127_2003229_38 Belongs to the RNA methyltransferase TrmD family K00554,K01770 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000000219 237.0
TLS2_k127_2003229_39 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000002419 226.0
TLS2_k127_2003229_4 Superfamily I DNA and RNA helicases and helicase subunits - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 656.0
TLS2_k127_2003229_40 Stage II sporulation protein M - - - 0.000000000000000000000000000000000000000000000000000000000006839 221.0
TLS2_k127_2003229_41 membrane-associated Zn-dependent proteases 1 K11749 GO:0008150,GO:0040007 - 0.00000000000000000000000000000000000000000000000000000000003456 219.0
TLS2_k127_2003229_42 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000001258 209.0
TLS2_k127_2003229_43 uracil phosphoribosyltransferase K00761 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000001594 212.0
TLS2_k127_2003229_44 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000001031 212.0
TLS2_k127_2003229_45 protein histidine kinase activity K03320 - - 0.00000000000000000000000000000000000000000000000000000001392 217.0
TLS2_k127_2003229_46 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000002053 214.0
TLS2_k127_2003229_47 DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000007735 219.0
TLS2_k127_2003229_48 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000003806 216.0
TLS2_k127_2003229_49 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000002378 197.0
TLS2_k127_2003229_5 RecF/RecN/SMC N terminal domain K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 630.0
TLS2_k127_2003229_50 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000000007518 197.0
TLS2_k127_2003229_51 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.0000000000000000000000000000000000000000000000006549 188.0
TLS2_k127_2003229_52 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000489 181.0
TLS2_k127_2003229_53 glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000005196 179.0
TLS2_k127_2003229_54 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000000000003766 170.0
TLS2_k127_2003229_55 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000004887 161.0
TLS2_k127_2003229_56 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.0000000000000000000000000000000000002758 153.0
TLS2_k127_2003229_57 SatD family (SatD) - - - 0.00000000000000000000000000000000004138 143.0
TLS2_k127_2003229_58 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000007982 133.0
TLS2_k127_2003229_59 - - - - 0.000000000000000000000000000000001024 134.0
TLS2_k127_2003229_6 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006095 584.0
TLS2_k127_2003229_60 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000001882 134.0
TLS2_k127_2003229_61 Methyltransferase K08316 - 2.1.1.171 0.00000000000000000000000000000008163 131.0
TLS2_k127_2003229_62 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000000000002474 136.0
TLS2_k127_2003229_63 RDD family - - - 0.000000000000000000000000000001825 130.0
TLS2_k127_2003229_64 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.000000000000000000000000000002094 127.0
TLS2_k127_2003229_65 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.0000000000000000000000000000116 122.0
TLS2_k127_2003229_66 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.00000000000000000000000000003634 124.0
TLS2_k127_2003229_67 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000002135 131.0
TLS2_k127_2003229_68 PFAM membrane protein of uknown function UCP014873 - - - 0.00000000000000000000000001432 117.0
TLS2_k127_2003229_69 AsnC family - - - 0.00000000000000000000000002413 121.0
TLS2_k127_2003229_7 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003634 577.0
TLS2_k127_2003229_70 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.000000000000000000000000107 113.0
TLS2_k127_2003229_71 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000000002371 109.0
TLS2_k127_2003229_72 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000003912 109.0
TLS2_k127_2003229_73 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis - - - 0.00000000000000000000002715 109.0
TLS2_k127_2003229_74 HAD-superfamily hydrolase, subfamily IA, variant 1 K01091 - 3.1.3.18 0.0000000000000000000001899 107.0
TLS2_k127_2003229_75 metal-binding, possibly nucleic acid-binding protein K07040 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000005221 102.0
TLS2_k127_2003229_76 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000001614 93.0
TLS2_k127_2003229_77 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000000000000549 89.0
TLS2_k127_2003229_78 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000006593 89.0
TLS2_k127_2003229_79 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.000000000000000003256 91.0
TLS2_k127_2003229_8 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 521.0
TLS2_k127_2003229_80 PspC domain - - - 0.000000000000000003651 96.0
TLS2_k127_2003229_81 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000001945 85.0
TLS2_k127_2003229_82 Protein of unknown function (DUF503) - - - 0.0000000000000003219 81.0
TLS2_k127_2003229_83 enzyme binding K00567,K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 0.0000000000005073 79.0
TLS2_k127_2003229_84 - - - - 0.000000000002096 78.0
TLS2_k127_2003229_85 Psort location CytoplasmicMembrane, score - - - 0.000000000002172 72.0
TLS2_k127_2003229_86 - - - - 0.00000000001632 76.0
TLS2_k127_2003229_87 ABC-2 family transporter protein K01992 - - 0.000000000316 70.0
TLS2_k127_2003229_88 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000003181 67.0
TLS2_k127_2003229_89 Cold shock K03704 - - 0.000000001686 66.0
TLS2_k127_2003229_9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 490.0
TLS2_k127_2003229_90 Belongs to the UPF0109 family K06960 - - 0.000000003737 66.0
TLS2_k127_2003229_91 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.00000007374 62.0
TLS2_k127_2003229_92 Belongs to the UPF0102 family K07460 - - 0.000004013 57.0
TLS2_k127_2003229_93 Domain of unknown function (DUF4350) - - - 0.0004518 52.0
TLS2_k127_2124883_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1064.0
TLS2_k127_2124883_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 4.295e-218 694.0
TLS2_k127_2124883_10 bifunctional deaminase-reductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000004936 220.0
TLS2_k127_2124883_11 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000001669 231.0
TLS2_k127_2124883_12 ABC-type sugar transport system, permease component K02026 - - 0.0000000000000000000000000000000000000000000000000000000002958 214.0
TLS2_k127_2124883_13 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000000000001201 217.0
TLS2_k127_2124883_14 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000001654 197.0
TLS2_k127_2124883_15 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000003506 185.0
TLS2_k127_2124883_16 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000006939 179.0
TLS2_k127_2124883_17 enzyme of poly-gamma-glutamate biosynthesis (Capsule formation) K07282 - - 0.00000000000000000000000000000000000000000000551 179.0
TLS2_k127_2124883_18 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000001411 172.0
TLS2_k127_2124883_19 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000001102 149.0
TLS2_k127_2124883_2 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0008661,GO:0009058,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901363,GO:1901576,GO:1901681 2.2.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 592.0
TLS2_k127_2124883_20 Protein of unknown function (DUF3151) - - - 0.000000000000000000000000000000000003695 142.0
TLS2_k127_2124883_21 Transcriptional regulator PadR-like family K10947 - - 0.000000000000000000000000000000000004629 145.0
TLS2_k127_2124883_22 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000001053 146.0
TLS2_k127_2124883_23 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000001366 109.0
TLS2_k127_2124883_24 cellular response to DNA damage stimulus K07340 - - 0.0000000000000000000002717 106.0
TLS2_k127_2124883_25 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000544 112.0
TLS2_k127_2124883_26 - - - - 0.00000000000000000000999 98.0
TLS2_k127_2124883_27 Putative zinc-finger - - - 0.0000000000000000007445 94.0
TLS2_k127_2124883_28 Bacterial extracellular solute-binding protein K02027,K17329 - - 0.0000000000000001682 93.0
TLS2_k127_2124883_29 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.0000000004093 63.0
TLS2_k127_2124883_3 Aminotransferase class-V K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 487.0
TLS2_k127_2124883_30 - - - - 0.000000002364 64.0
TLS2_k127_2124883_31 Lysyl oxidase - - - 0.000000003405 70.0
TLS2_k127_2124883_32 domain, Protein K01729,K02396,K09942 - 4.2.2.3 0.0000001646 64.0
TLS2_k127_2124883_33 - - - - 0.0000003719 61.0
TLS2_k127_2124883_4 beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 417.0
TLS2_k127_2124883_5 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 389.0
TLS2_k127_2124883_6 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 346.0
TLS2_k127_2124883_7 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009358 290.0
TLS2_k127_2124883_8 Transcriptional regulatory protein, C terminal K07776 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000006027 260.0
TLS2_k127_2124883_9 PFAM Fatty acid desaturase, type 2 K03921 - 1.14.19.11,1.14.19.2,1.14.19.26 0.000000000000000000000000000000000000000000000000000000000000000000000005717 253.0
TLS2_k127_2157761_0 UDP-glucose 4-epimerase K01784,K12448 - 5.1.3.2,5.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 439.0
TLS2_k127_2157761_1 PFAM Pyruvate carboxyltransferase K01640,K18314 - 4.1.3.4,4.1.3.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 349.0
TLS2_k127_2157761_10 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000001026 177.0
TLS2_k127_2157761_11 Bifunctional nuclease K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000001323 173.0
TLS2_k127_2157761_12 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000008463 162.0
TLS2_k127_2157761_13 merR family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000002116 164.0
TLS2_k127_2157761_14 Histidine triad (Hit) protein K02503 - - 0.000000000000000000000000000000000000000003743 158.0
TLS2_k127_2157761_15 - - - - 0.0000000000000000000000000000005835 139.0
TLS2_k127_2157761_16 Cytidylate kinase-like family K00760 - 2.4.2.8 0.00000000000000000000000000002815 133.0
TLS2_k127_2157761_17 FHA domain containing protein - - - 0.00000000000000000000000001069 119.0
TLS2_k127_2157761_18 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide - - - 0.00000000000000009831 94.0
TLS2_k127_2157761_2 Adenosine/AMP deaminase K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 323.0
TLS2_k127_2157761_3 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007595 293.0
TLS2_k127_2157761_4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001185 285.0
TLS2_k127_2157761_5 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000005374 216.0
TLS2_k127_2157761_6 hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000306 209.0
TLS2_k127_2157761_7 Belongs to the peptidase S11 family K01286,K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000002619 207.0
TLS2_k127_2157761_8 Belongs to the UPF0301 (AlgH) family K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000901 183.0
TLS2_k127_2157761_9 SMART regulatory protein, MerR - - - 0.0000000000000000000000000000000000000000000006722 172.0
TLS2_k127_2210445_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 3.499e-212 670.0
TLS2_k127_2210445_1 PFAM Carbamoyl-phosphate synthase L chain K11263 - 6.3.4.14,6.4.1.2,6.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 569.0
TLS2_k127_2210445_10 Metallo-peptidase family M12 - - - 0.0000000000002653 82.0
TLS2_k127_2210445_11 Evidence 2b Function of strongly homologous gene - - - 0.0001912 48.0
TLS2_k127_2210445_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000579 495.0
TLS2_k127_2210445_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007223 423.0
TLS2_k127_2210445_4 Bacterial sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 376.0
TLS2_k127_2210445_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 365.0
TLS2_k127_2210445_6 glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 293.0
TLS2_k127_2210445_7 PFAM UDP-glucose GDP-mannose dehydrogenase family, NAD binding domain K02472,K13015 - 1.1.1.136,1.1.1.336 0.0000000000000000000000000000000000000000000000000000000000000000000000000002258 263.0
TLS2_k127_2210445_8 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000002892 163.0
TLS2_k127_2210445_9 Polysaccharide biosynthesis protein - - - 0.000000000000000000002147 108.0
TLS2_k127_2341600_0 Adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 525.0
TLS2_k127_2341600_1 Stage II sporulation E family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 443.0
TLS2_k127_2341600_10 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000207 171.0
TLS2_k127_2341600_11 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000006365 167.0
TLS2_k127_2341600_12 Histidine kinase - - - 0.00000000000000000000000000000000000000005645 169.0
TLS2_k127_2341600_13 Histidine kinase - - - 0.0000000000000000000000000000000000000003288 171.0
TLS2_k127_2341600_14 Histidine kinase - - - 0.0000000000000000000000000000000000003819 162.0
TLS2_k127_2341600_15 Belongs to the peptidase S8 family - - - 0.00000000000000000338 98.0
TLS2_k127_2341600_16 - - - - 0.00000004417 64.0
TLS2_k127_2341600_2 Transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004249 467.0
TLS2_k127_2341600_3 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 348.0
TLS2_k127_2341600_4 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 299.0
TLS2_k127_2341600_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001997 260.0
TLS2_k127_2341600_6 TIGRFAM DNA polymerase LigD, polymerase domain protein K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000001512 268.0
TLS2_k127_2341600_7 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000007913 215.0
TLS2_k127_2341600_8 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000004117 201.0
TLS2_k127_2341600_9 Histidine kinase - - - 0.00000000000000000000000000000000000000000001201 187.0
TLS2_k127_2343320_0 GMC oxidoreductase K00108 - 1.1.99.1 1.511e-290 899.0
TLS2_k127_2343320_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 587.0
TLS2_k127_2343320_10 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006505 351.0
TLS2_k127_2343320_11 COG4175 ABC-type proline glycine betaine transport system ATPase component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007327 358.0
TLS2_k127_2343320_12 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 297.0
TLS2_k127_2343320_13 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K02029 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 302.0
TLS2_k127_2343320_14 ABC transporter K02010,K02052,K02062 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004334 279.0
TLS2_k127_2343320_15 Binding-protein-dependent transport system inner membrane component K02029 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004617 285.0
TLS2_k127_2343320_16 Signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001548 288.0
TLS2_k127_2343320_17 Bacterial periplasmic substrate-binding proteins K02030,K02424,K17073 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000457 272.0
TLS2_k127_2343320_18 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007166 286.0
TLS2_k127_2343320_19 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01190 - 3.2.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000001734 271.0
TLS2_k127_2343320_2 COG1960 Acyl-CoA dehydrogenases K20035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 583.0
TLS2_k127_2343320_20 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001102 255.0
TLS2_k127_2343320_21 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005269 252.0
TLS2_k127_2343320_22 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007144 252.0
TLS2_k127_2343320_23 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000009834 254.0
TLS2_k127_2343320_24 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009935 251.0
TLS2_k127_2343320_25 Fungal family of unknown function (DUF1776) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001487 246.0
TLS2_k127_2343320_26 NADPH quinone reductase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000006483 238.0
TLS2_k127_2343320_27 Sir2 family K12410 - - 0.0000000000000000000000000000000000000000000000000000000000055 218.0
TLS2_k127_2343320_28 glycine betaine transport K02002 - - 0.00000000000000000000000000000000000000000000000000006035 211.0
TLS2_k127_2343320_29 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000007094 189.0
TLS2_k127_2343320_3 glutathione S-transferase K07393 - 1.8.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000465 532.0
TLS2_k127_2343320_30 Secreted repeat of unknown function - - - 0.0000000000000000000000000000000000007396 146.0
TLS2_k127_2343320_31 Aminoacyl-tRNA editing domain K19055 - - 0.0000000000000000000000000000000003521 138.0
TLS2_k127_2343320_33 Transcriptional regulator - - - 0.00000000000000000000000000002026 123.0
TLS2_k127_2343320_34 - - - - 0.0000000000000000000000001194 122.0
TLS2_k127_2343320_35 glyoxalase - - - 0.00000000000000000001245 97.0
TLS2_k127_2343320_36 Sporulation and spore germination - - - 0.00000000000001871 87.0
TLS2_k127_2343320_37 Thioesterase superfamily K07107 - - 0.0000000000008659 75.0
TLS2_k127_2343320_38 COG3794 Plastocyanin - - - 0.000000007383 63.0
TLS2_k127_2343320_39 Cupin domain - - - 0.00000005316 64.0
TLS2_k127_2343320_4 Transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006328 454.0
TLS2_k127_2343320_40 Late competence development protein ComFB K02241 - - 0.000004761 53.0
TLS2_k127_2343320_41 Anti-sigma-K factor rskA - GO:0000988,GO:0000989,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006417,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0010608,GO:0016020,GO:0016989,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - 0.0009444 49.0
TLS2_k127_2343320_5 ABC-type Fe3 transport system permease component K02011,K02063 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008652 449.0
TLS2_k127_2343320_6 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 399.0
TLS2_k127_2343320_7 ABC transporter, periplasmic binding protein, thiB subfamily K02064 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 378.0
TLS2_k127_2343320_8 ABC-type proline glycine betaine transport system permease component K02001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005837 384.0
TLS2_k127_2343320_9 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003108 359.0
TLS2_k127_2345802_0 4Fe-4S dicluster domain - - - 2.276e-260 834.0
TLS2_k127_2345802_1 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 495.0
TLS2_k127_2345802_10 Male sterility protein K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000006514 208.0
TLS2_k127_2345802_11 Domain of unknown function (DUF1990) - - - 0.00000000000000000000000000000000000000000000000000003978 197.0
TLS2_k127_2345802_12 Domain of unknown function (DUF1990) - - - 0.0000000000000000000000000000000000000000000001221 176.0
TLS2_k127_2345802_13 - - - - 0.0000000000000000000000000000000000007393 160.0
TLS2_k127_2345802_14 Pfam Zn-finger in ubiquitin-hydrolases and other protein K03455 - - 0.00000000000000000000000000000000455 132.0
TLS2_k127_2345802_15 - - - - 0.0000000000000000000000000008321 125.0
TLS2_k127_2345802_16 DNA-binding transcription factor activity - - - 0.000000000000000000000000004052 115.0
TLS2_k127_2345802_17 CHAT domain - - - 0.00000000000000000000002281 110.0
TLS2_k127_2345802_18 Protein of unknown function (DUF3039) - - - 0.0000000000000000000008442 98.0
TLS2_k127_2345802_19 FxsA cytoplasmic membrane protein K07113 - - 0.000000000000000000001329 104.0
TLS2_k127_2345802_2 PFAM AMP-dependent synthetase and ligase K01897,K18661 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 494.0
TLS2_k127_2345802_20 Beta-lactamase superfamily domain - - - 0.000000000000003027 85.0
TLS2_k127_2345802_21 Restriction endonuclease - - - 0.0000000006789 68.0
TLS2_k127_2345802_22 pyridoxamine 5-phosphate K05558 - - 0.000000151 62.0
TLS2_k127_2345802_23 - - - - 0.0000002121 64.0
TLS2_k127_2345802_24 His Kinase A (phosphoacceptor) domain - - - 0.00007712 55.0
TLS2_k127_2345802_25 diguanylate cyclase - - - 0.0005682 49.0
TLS2_k127_2345802_3 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 386.0
TLS2_k127_2345802_4 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007707 357.0
TLS2_k127_2345802_5 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006956 285.0
TLS2_k127_2345802_6 Glutamine cyclotransferase K00683 - 2.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005205 289.0
TLS2_k127_2345802_7 response to heat K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008223 284.0
TLS2_k127_2345802_8 HhH-GPD superfamily base excision DNA repair protein - - - 0.0000000000000000000000000000000000000000000000000000000000003943 229.0
TLS2_k127_2345802_9 FR47-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000006091 220.0
TLS2_k127_2363170_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 0.0 1014.0
TLS2_k127_2363170_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.039e-246 777.0
TLS2_k127_2363170_10 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit K11381,K21417 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 387.0
TLS2_k127_2363170_11 Dehydrogenase E1 component K21416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008799 381.0
TLS2_k127_2363170_12 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 391.0
TLS2_k127_2363170_13 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 347.0
TLS2_k127_2363170_14 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 339.0
TLS2_k127_2363170_15 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004122 343.0
TLS2_k127_2363170_16 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 308.0
TLS2_k127_2363170_17 Type ii secretion system protein e K02283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008576 306.0
TLS2_k127_2363170_18 HAD-superfamily subfamily IB hydrolase, TIGR01490 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002818 274.0
TLS2_k127_2363170_19 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627,K00658,K09699 - 2.3.1.12,2.3.1.168,2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000009468 277.0
TLS2_k127_2363170_2 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 6.948e-241 765.0
TLS2_k127_2363170_20 PTS system glucitol sorbitol-specific K02783 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000341 256.0
TLS2_k127_2363170_21 Cobalt ABC transporter K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002062 259.0
TLS2_k127_2363170_22 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000527 254.0
TLS2_k127_2363170_23 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006729 239.0
TLS2_k127_2363170_24 Sorbitol phosphotransferase enzyme II C-terminus K02782,K02783 - 2.7.1.198 0.000000000000000000000000000000000000000000000000000000000000000000008312 246.0
TLS2_k127_2363170_25 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000001051 213.0
TLS2_k127_2363170_26 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000001843 202.0
TLS2_k127_2363170_27 protein-phosphocysteine-sugar phosphotransferase activity K02782,K02783 - 2.7.1.198 0.00000000000000000000000000000000000000000000000000003578 192.0
TLS2_k127_2363170_28 Transmembrane secretion effector K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000462 205.0
TLS2_k127_2363170_29 transport, permease protein K01992 - - 0.00000000000000000000000000000000000000000000000005511 196.0
TLS2_k127_2363170_3 DNA polymerase beta thumb K02347 - - 5.787e-214 684.0
TLS2_k127_2363170_30 Cell envelope-related transcriptional attenuator domain - - - 0.0000000000000000000000000000000000000000000000001598 204.0
TLS2_k127_2363170_31 Putative sugar-binding domain - - - 0.0000000000000000000000000000000000000000000000007116 186.0
TLS2_k127_2363170_32 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00991,K21681 - 1.1.1.405,2.7.7.40,2.7.7.60 0.000000000000000000000000000000000000000000000001693 184.0
TLS2_k127_2363170_33 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.0000000000000000000000000000000000000000000003212 171.0
TLS2_k127_2363170_34 Belongs to the UPF0502 family K09915 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000002951 169.0
TLS2_k127_2363170_35 TIGRFAM DNA polymerase III, delta prime subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000001357 164.0
TLS2_k127_2363170_36 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000001491 154.0
TLS2_k127_2363170_37 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000001581 146.0
TLS2_k127_2363170_38 PTS system glucitol sorbitol-specific IIA component K02781 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0051179,GO:0051234,GO:0071702 2.7.1.198 0.000000000000000000000004078 108.0
TLS2_k127_2363170_39 alpha-ribazole phosphatase activity K15634,K22306 - 3.1.3.85,5.4.2.12 0.00000000000000000000001006 118.0
TLS2_k127_2363170_4 DEAH box helicase K06877 - - 2.336e-208 674.0
TLS2_k127_2363170_40 Clp amino terminal domain, pathogenicity island component - - - 0.0000000000000000000000689 107.0
TLS2_k127_2363170_41 PTS HPr component phosphorylation site K11189 - - 0.0000000000000000001353 91.0
TLS2_k127_2363170_42 - - - - 0.00000000000000001483 85.0
TLS2_k127_2363170_43 Belongs to the phosphoglycerate mutase family - - - 0.0000000000002908 84.0
TLS2_k127_2363170_44 carboxymethylenebutenolidase activity K01061,K07017 - 3.1.1.45 0.0000000000005259 76.0
TLS2_k127_2363170_45 PFAM methyltransferase - - - 0.00000000005778 76.0
TLS2_k127_2363170_46 TadE-like protein - - - 0.0009913 49.0
TLS2_k127_2363170_5 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005137 541.0
TLS2_k127_2363170_6 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 477.0
TLS2_k127_2363170_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 464.0
TLS2_k127_2363170_8 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003842 420.0
TLS2_k127_2363170_9 Peptidase S8 and S53 subtilisin kexin sedolisin K17734 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 426.0
TLS2_k127_2363435_0 Oxidoreductase K10219 - 1.1.1.312 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 439.0
TLS2_k127_2363435_1 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003757 403.0
TLS2_k127_2363435_10 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01856,K19802 - 5.1.1.20,5.5.1.1 0.00000000000000000000000000000000000000000000000000005147 205.0
TLS2_k127_2363435_11 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000001149 205.0
TLS2_k127_2363435_12 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000003706 194.0
TLS2_k127_2363435_13 ATPases associated with a variety of cellular activities K02049 - - 0.00000000000000000000000000000000000000000000000001625 194.0
TLS2_k127_2363435_14 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000002011 176.0
TLS2_k127_2363435_15 PFAM Bacterial regulatory proteins, gntR family - - - 0.00000000000000000000000000000000000009633 151.0
TLS2_k127_2363435_16 carboxymuconolactone decarboxylase - - - 0.000000000000000000000000000000000001238 145.0
TLS2_k127_2363435_17 6-phosphogluconate dehydrogenase - - - 0.00000000000000000000000000000000003751 147.0
TLS2_k127_2363435_18 Arabinose efflux permease family protein - - - 0.0000000000000000000000000000000189 146.0
TLS2_k127_2363435_19 histidine kinase A domain protein - - - 0.00000000000000000000000000005114 137.0
TLS2_k127_2363435_2 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000563 329.0
TLS2_k127_2363435_20 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000007018 127.0
TLS2_k127_2363435_21 NMT1/THI5 like - - - 0.000000000000000441 82.0
TLS2_k127_2363435_22 - - - - 0.0000000005494 67.0
TLS2_k127_2363435_23 Histidine kinase - - - 0.0000002407 64.0
TLS2_k127_2363435_3 MmgE/PrpD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 315.0
TLS2_k127_2363435_4 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 298.0
TLS2_k127_2363435_5 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 295.0
TLS2_k127_2363435_6 CsiD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006563 287.0
TLS2_k127_2363435_7 PFAM amidohydrolase 2 K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000001261 270.0
TLS2_k127_2363435_8 PFAM amidohydrolase 2 K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000006933 274.0
TLS2_k127_2363435_9 Belongs to the CinA family K03742,K03743 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000001324 248.0
TLS2_k127_2384748_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000001741 226.0
TLS2_k127_2384748_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000005009 126.0
TLS2_k127_2384748_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000009078 107.0
TLS2_k127_2384748_3 - - - - 0.000000000000000001319 97.0
TLS2_k127_2384748_4 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000002194 72.0
TLS2_k127_2392633_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372,K02567 - - 0.0 1201.0
TLS2_k127_2392633_1 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006539 614.0
TLS2_k127_2392633_10 MOSC domain - - - 0.000000000000000000000000000000000000000000000008106 182.0
TLS2_k127_2392633_11 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000001305 181.0
TLS2_k127_2392633_12 cobalamin binding protein - - - 0.00000000000000000000000000000000000003686 156.0
TLS2_k127_2392633_13 oxidoreductase activity, acting on diphenols and related substances as donors - - - 0.0000000000000000000000000000000003523 146.0
TLS2_k127_2392633_14 - - - - 0.00000000000000000000000000002181 121.0
TLS2_k127_2392633_15 Histidine kinase - - - 0.0000000000000000000000006851 119.0
TLS2_k127_2392633_16 Histidine kinase - - - 0.00000000000000000000001575 114.0
TLS2_k127_2392633_17 Protein conserved in bacteria K03886 - - 0.00000000000000000003233 99.0
TLS2_k127_2392633_18 Multicopper oxidase K00368 - 1.7.2.1 0.0000000000006266 82.0
TLS2_k127_2392633_19 Polyketide cyclase / dehydrase and lipid transport - - - 0.0001269 48.0
TLS2_k127_2392633_2 gluconolactonase activity K13276,K14274 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 651.0
TLS2_k127_2392633_3 nitrite transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007037 463.0
TLS2_k127_2392633_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 305.0
TLS2_k127_2392633_5 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 302.0
TLS2_k127_2392633_6 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007688 302.0
TLS2_k127_2392633_7 HPP family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000837 291.0
TLS2_k127_2392633_8 membrane K07149 - - 0.0000000000000000000000000000000000000000000000000000000000000006666 225.0
TLS2_k127_2392633_9 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000001668 188.0
TLS2_k127_2468617_0 NMT1/THI5 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 336.0
TLS2_k127_2468617_1 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004296 266.0
TLS2_k127_2468617_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000001073 188.0
TLS2_k127_2468617_3 FCD - - - 0.000000000000000000000000000000000001276 151.0
TLS2_k127_2478279_0 Cation efflux family K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003392 349.0
TLS2_k127_2478279_1 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000000000002577 165.0
TLS2_k127_2478279_2 PFAM PspC domain protein K03973 - - 0.00000000000000000000000000000009414 132.0
TLS2_k127_2478279_3 membrane - - - 0.00000000000000000000000000118 121.0
TLS2_k127_2478279_4 Domain of unknown function (DUF1918) - - - 0.0000000000000000001439 93.0
TLS2_k127_2478279_5 - - - - 0.00000000000000001083 87.0
TLS2_k127_2478279_6 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.0000000000002573 75.0
TLS2_k127_2482648_0 Berberine and berberine like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 494.0
TLS2_k127_2482648_1 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007207 437.0
TLS2_k127_2482648_10 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000006459 257.0
TLS2_k127_2482648_11 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000001568 207.0
TLS2_k127_2482648_12 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000003627 195.0
TLS2_k127_2482648_13 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.00000000000000000000000000000000000000000008593 171.0
TLS2_k127_2482648_14 Domain of unknown function (DUF2383) - - - 0.000000000000000000000000000004547 125.0
TLS2_k127_2482648_15 cell envelope-related transcriptional attenuator - - - 0.0000000000000000000000008139 117.0
TLS2_k127_2482648_16 Metallo-peptidase family M12 - - - 0.00000000000005543 85.0
TLS2_k127_2482648_17 ABC transporter, phosphonate, periplasmic substrate-binding protein K02051 - - 0.0000000001053 74.0
TLS2_k127_2482648_18 - - - - 0.00005962 56.0
TLS2_k127_2482648_2 Peptidase family U32 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 396.0
TLS2_k127_2482648_3 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 415.0
TLS2_k127_2482648_4 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 349.0
TLS2_k127_2482648_5 thiolester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005871 306.0
TLS2_k127_2482648_6 Fumarylacetoacetate (FAA) hydrolase family K14259 - 4.2.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 305.0
TLS2_k127_2482648_7 PFAM ABC transporter related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001656 261.0
TLS2_k127_2482648_8 Gluconolactonase K01053,K14274 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000001116 247.0
TLS2_k127_2482648_9 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000009244 242.0
TLS2_k127_2529322_0 FAD binding domain K21401 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 1.3.99.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005686 458.0
TLS2_k127_2529322_1 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000002319 211.0
TLS2_k127_2539781_0 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006243 367.0
TLS2_k127_2539781_1 PFAM Band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006011 345.0
TLS2_k127_2543946_0 2-oxoglutarate dehydrogenase C-terminal K00164 - 1.2.4.2 0.0 1336.0
TLS2_k127_2543946_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 1.033e-233 731.0
TLS2_k127_2543946_10 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000003362 181.0
TLS2_k127_2543946_11 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000009189 156.0
TLS2_k127_2543946_12 Alpha/beta hydrolase family K03928 - 3.1.1.1 0.000000000000000000000000000000003126 143.0
TLS2_k127_2543946_13 Histidine kinase K18350 - 2.7.13.3 0.000000000000000000000000288 119.0
TLS2_k127_2543946_14 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000442 112.0
TLS2_k127_2543946_15 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000004843 93.0
TLS2_k127_2543946_16 Catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway K01468 - 3.5.2.7 0.0000000000000000006589 99.0
TLS2_k127_2543946_17 PFAM Bacterial membrane flanked domain - - - 0.0000000000000004172 88.0
TLS2_k127_2543946_18 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.0000000000001001 82.0
TLS2_k127_2543946_19 Thioesterase superfamily - - - 0.00000007399 59.0
TLS2_k127_2543946_2 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 369.0
TLS2_k127_2543946_3 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 348.0
TLS2_k127_2543946_4 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 313.0
TLS2_k127_2543946_5 Patched family K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001183 294.0
TLS2_k127_2543946_6 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000003536 254.0
TLS2_k127_2543946_7 3-isopropylmalate dehydratase activity K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000005374 234.0
TLS2_k127_2543946_8 Belongs to the NUDIX hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000001082 219.0
TLS2_k127_2543946_9 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000006674 196.0
TLS2_k127_2604096_0 Belongs to the heme-copper respiratory oxidase family K15408 - 1.9.3.1 9.84e-217 713.0
TLS2_k127_2604096_1 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity K03583 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.5 3.758e-212 703.0
TLS2_k127_2604096_10 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 301.0
TLS2_k127_2604096_11 CAAX protease self-immunity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009983 293.0
TLS2_k127_2604096_12 helix_turn_helix gluconate operon transcriptional repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002224 265.0
TLS2_k127_2604096_13 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006077 248.0
TLS2_k127_2604096_14 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000000000000000000000000000001899 240.0
TLS2_k127_2604096_15 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000002067 234.0
TLS2_k127_2604096_16 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000002374 218.0
TLS2_k127_2604096_17 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000002074 207.0
TLS2_k127_2604096_18 Phage integrase family K04763 - - 0.000000000000000000000000000000000000000000000000000004232 206.0
TLS2_k127_2604096_19 Abhydrolase domain containing 18 - - - 0.0000000000000000000000000000000000000000000000000002424 198.0
TLS2_k127_2604096_2 PD-(D/E)XK nuclease superfamily K03582 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.1.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 646.0
TLS2_k127_2604096_20 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000000007533 184.0
TLS2_k127_2604096_21 Fic/DOC family K07341 - - 0.000000000000000000000000000000000000000000000000619 177.0
TLS2_k127_2604096_22 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000004689 179.0
TLS2_k127_2604096_23 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000785 179.0
TLS2_k127_2604096_24 Pfam:Pyridox_oxidase - - - 0.00000000000000000000000000000000000000001357 160.0
TLS2_k127_2604096_25 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.00000000000000000000000000000000000000002122 173.0
TLS2_k127_2604096_26 Protein of unknown function (DUF459) K09795 - - 0.00000000000000000000000000000000000001426 162.0
TLS2_k127_2604096_27 Methyltransferase domain - - - 0.00000000000000000000000000000000000001574 167.0
TLS2_k127_2604096_28 CAAX protease self-immunity - - - 0.000000000000000000000000000000000002118 148.0
TLS2_k127_2604096_29 acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000004997 156.0
TLS2_k127_2604096_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 542.0
TLS2_k127_2604096_30 Uncharacterized conserved protein (DUF2277) - - - 0.0000000000000000000000000000000005396 139.0
TLS2_k127_2604096_31 cytochrome C K03889 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000006017 147.0
TLS2_k127_2604096_32 Rieske [2Fe-2S] domain K03890 - - 0.000000000000000000000000000000007135 143.0
TLS2_k127_2604096_33 Cytochrome c - - - 0.0000000000000000000000001318 115.0
TLS2_k127_2604096_34 NMT1-like family K02051,K15598 - - 0.0000000000000000000001637 112.0
TLS2_k127_2604096_36 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.0000000000000001111 93.0
TLS2_k127_2604096_37 PFAM Nucleotidyltransferase domain K07075 - - 0.00000000000147 75.0
TLS2_k127_2604096_38 PFAM Polyketide cyclase dehydrase - - - 0.00000002959 63.0
TLS2_k127_2604096_39 Cupin domain-containing protein - - - 0.000003606 58.0
TLS2_k127_2604096_4 MBOAT, membrane-bound O-acyltransferase family K03739,K19294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 517.0
TLS2_k127_2604096_40 addiction module antidote protein, CC2985 family - GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351 - 0.00008068 48.0
TLS2_k127_2604096_5 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008844 415.0
TLS2_k127_2604096_6 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 365.0
TLS2_k127_2604096_7 Cytochrome b K03891 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 383.0
TLS2_k127_2604096_8 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 357.0
TLS2_k127_2604096_9 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 315.0
TLS2_k127_2660573_0 Thiolase, C-terminal domain K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 542.0
TLS2_k127_2660573_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007696 539.0
TLS2_k127_2660573_10 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.000000000000000000000000000000000000000000000000000000000000002064 229.0
TLS2_k127_2660573_11 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000007734 228.0
TLS2_k127_2660573_12 ANTAR domain protein - - - 0.000000000000000000000000000000000000000000000000000000007123 206.0
TLS2_k127_2660573_13 TIGRFAM FeS assembly protein SufD K09015 - - 0.0000000000000000000000000000000000000000000000000000001407 213.0
TLS2_k127_2660573_14 VanW family - - - 0.0000000000000000000000000000000000000000000008462 183.0
TLS2_k127_2660573_15 YbaK prolyl-tRNA synthetase associated region - - - 0.0000000000000000000000000000000000000128 153.0
TLS2_k127_2660573_16 NifU-like N terminal domain K04488 - - 0.000000000000000000000000000000000005447 142.0
TLS2_k127_2660573_17 Rieske-like [2Fe-2S] domain K05710 - - 0.000000000000000000002075 109.0
TLS2_k127_2660573_18 ANTAR - - - 0.00000000000000005933 92.0
TLS2_k127_2660573_19 STAS domain - - - 0.00005115 51.0
TLS2_k127_2660573_2 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 441.0
TLS2_k127_2660573_20 - - - - 0.0001025 53.0
TLS2_k127_2660573_3 Involved in chromosome partitioning - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009687 383.0
TLS2_k127_2660573_4 ATPases associated with a variety of cellular activities K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 301.0
TLS2_k127_2660573_5 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000643 286.0
TLS2_k127_2660573_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007964 287.0
TLS2_k127_2660573_7 Uracil DNA glycosylase superfamily K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009687 284.0
TLS2_k127_2660573_8 ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005735 263.0
TLS2_k127_2660573_9 aminopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000002122 255.0
TLS2_k127_2663186_0 Belongs to the aldehyde dehydrogenase family K13821 - 1.2.1.88,1.5.5.2 0.0 1086.0
TLS2_k127_2663186_1 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 8.397e-300 962.0
TLS2_k127_2663186_10 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 296.0
TLS2_k127_2663186_11 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000001131 273.0
TLS2_k127_2663186_12 Belongs to the UPF0255 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008309 275.0
TLS2_k127_2663186_13 ABC transporter, ATP-binding protein K01990,K09691,K09693 - 3.6.3.40 0.000000000000000000000000000000000000000000000000000000000000003997 236.0
TLS2_k127_2663186_14 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000001259 227.0
TLS2_k127_2663186_15 cytidylyl-transferase K00983 - 2.7.7.43 0.000000000000000000000000000000000000000000000000000000000003691 228.0
TLS2_k127_2663186_16 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000001896 191.0
TLS2_k127_2663186_17 pathogenesis - - - 0.00000000000000000000000000000000000000000000005144 196.0
TLS2_k127_2663186_18 Oxidoreductase FAD-binding domain K00529,K02613 GO:0000166,GO:0003674,GO:0005488,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0036094,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097159,GO:0098754,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 1.18.1.3 0.000000000000000000000000000000000000000000002125 174.0
TLS2_k127_2663186_19 ABC-2 type transporter K09692 - - 0.00000000000000000000000000000000000000003601 164.0
TLS2_k127_2663186_2 ABC transporter transmembrane region K06147 - - 1.796e-271 873.0
TLS2_k127_2663186_20 isomerase activity - - - 0.000000000000000000000000000000000000005613 169.0
TLS2_k127_2663186_22 Beta-lactamase enzyme family - - - 0.0000000000000000000000000007095 125.0
TLS2_k127_2663186_23 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000005243 118.0
TLS2_k127_2663186_25 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000192 102.0
TLS2_k127_2663186_28 ferredoxin K05337 - - 0.00000000000000003386 83.0
TLS2_k127_2663186_29 HNH nucleases - - - 0.000004152 55.0
TLS2_k127_2663186_3 ABC transporter K06147 - - 1.11e-246 779.0
TLS2_k127_2663186_4 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1.319e-215 688.0
TLS2_k127_2663186_5 phosphoribosyltransferase K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006655 539.0
TLS2_k127_2663186_6 Capsule synthesis protein K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008185 422.0
TLS2_k127_2663186_7 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 381.0
TLS2_k127_2663186_8 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 336.0
TLS2_k127_2663186_9 Glycosyl transferase family 2 K12992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008357 299.0
TLS2_k127_2697991_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 5.754e-311 975.0
TLS2_k127_2697991_1 Belongs to the 5'-nucleotidase family K01081 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 556.0
TLS2_k127_2697991_10 Peptidase M23 K21471 - - 0.0000000000000000000000000000000000000000000000000000006822 211.0
TLS2_k127_2697991_11 decarboxylase - - - 0.000000000000000000000000000000000000000000000000000003574 205.0
TLS2_k127_2697991_12 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000215 193.0
TLS2_k127_2697991_13 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000002171 181.0
TLS2_k127_2697991_14 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.0000000000000000000000000000000000000000001187 169.0
TLS2_k127_2697991_15 Histidine kinase - - - 0.0000000000000000000000000000000000000000072 171.0
TLS2_k127_2697991_16 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000002942 142.0
TLS2_k127_2697991_17 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.0000000000000000000000000000002885 135.0
TLS2_k127_2697991_18 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07171 - - 0.00000000000000000006367 93.0
TLS2_k127_2697991_19 - - - - 0.000000000002127 71.0
TLS2_k127_2697991_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 501.0
TLS2_k127_2697991_20 Competence protein - - - 0.00000006697 63.0
TLS2_k127_2697991_21 Trm112p-like protein K09791 - - 0.00000007949 64.0
TLS2_k127_2697991_22 - - - - 0.0000001454 55.0
TLS2_k127_2697991_23 Polyketide cyclase / dehydrase and lipid transport - - - 0.000001698 59.0
TLS2_k127_2697991_24 Protein of unknown function (DUF3499) - - - 0.0004135 46.0
TLS2_k127_2697991_3 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 468.0
TLS2_k127_2697991_4 RNB K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 414.0
TLS2_k127_2697991_5 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009391 368.0
TLS2_k127_2697991_6 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 364.0
TLS2_k127_2697991_7 cell division ATP-binding protein FtsE K09812 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 324.0
TLS2_k127_2697991_8 2 iron, 2 sulfur cluster binding K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 300.0
TLS2_k127_2697991_9 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 295.0
TLS2_k127_291821_0 PFAM ABC transporter related K02056 - 3.6.3.17 1.714e-194 620.0
TLS2_k127_291821_1 5'-nucleotidase, C-terminal domain K01081,K01119 - 3.1.3.5,3.1.3.6,3.1.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005068 612.0
TLS2_k127_291821_2 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 447.0
TLS2_k127_291821_3 ABC transporter substrate-binding protein PnrA-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007029 351.0
TLS2_k127_291821_4 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 352.0
TLS2_k127_291821_5 nucleoside hydrolase K01239,K01250,K10213 - 3.2.2.1,3.2.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 306.0
TLS2_k127_291821_6 queuosine salvage K09125 - - 0.0000000000000000000000000000000000000000000000000000007384 219.0
TLS2_k127_291821_7 cytochrome P-450 K00493 - 1.14.14.1 0.0000000000000000000000000000000000000000000000000000158 198.0
TLS2_k127_293368_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008562 546.0
TLS2_k127_293368_1 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 376.0
TLS2_k127_293368_10 - - - - 0.00000000000000003491 87.0
TLS2_k127_293368_11 - - - - 0.000000000000000796 81.0
TLS2_k127_293368_12 Fumarylacetoacetate (FAA) hydrolase family K01617 - 4.1.1.77 0.0000000000005436 79.0
TLS2_k127_293368_13 EamA-like transporter family - - - 0.0000006655 61.0
TLS2_k127_293368_14 Cupin domain - - - 0.0000428 51.0
TLS2_k127_293368_2 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004836 374.0
TLS2_k127_293368_3 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 291.0
TLS2_k127_293368_4 Amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000324 232.0
TLS2_k127_293368_5 PFAM iron dependent repressor K03709 - - 0.000000000000000000000000000000001355 139.0
TLS2_k127_293368_6 PFAM FAD dependent oxidoreductase K15736 - - 0.0000000000000000000000000000001552 125.0
TLS2_k127_293368_7 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000005699 129.0
TLS2_k127_293368_8 alcohol dehydrogenase - - - 0.0000000000000000000000000001937 128.0
TLS2_k127_293368_9 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.00000000000000000000000003736 110.0
TLS2_k127_2950445_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1063.0
TLS2_k127_2950445_1 Belongs to the GPAT DAPAT family K00631 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 460.0
TLS2_k127_2950445_10 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009014 340.0
TLS2_k127_2950445_11 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005486 315.0
TLS2_k127_2950445_12 Bacterial extracellular solute-binding protein K10232 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004333 314.0
TLS2_k127_2950445_13 Belongs to the helicase family. UvrD subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 317.0
TLS2_k127_2950445_14 ABC-type multidrug transport system, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002599 289.0
TLS2_k127_2950445_15 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006325 270.0
TLS2_k127_2950445_16 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005092 272.0
TLS2_k127_2950445_17 XdhC Rossmann domain K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004014 268.0
TLS2_k127_2950445_18 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001066 269.0
TLS2_k127_2950445_19 PD-(D/E)XK nuclease superfamily K07465 - - 0.0000000000000000000000000000000000000000000000000000000001914 216.0
TLS2_k127_2950445_2 Belongs to the helicase family. UvrD subfamily K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008157 478.0
TLS2_k127_2950445_20 carboxylic ester hydrolase activity K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000003142 207.0
TLS2_k127_2950445_21 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.000000000000000000000000000000000000000000000008054 177.0
TLS2_k127_2950445_22 Probable molybdopterin binding domain - - - 0.000000000000000000000000000000000000000009837 170.0
TLS2_k127_2950445_23 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.0000000000000000000000000000000000000002088 173.0
TLS2_k127_2950445_24 iron-sulfur cluster assembly K07400 - - 0.0000000000000000000000000000000000000002691 158.0
TLS2_k127_2950445_25 COG2202 FOG PAS PAC domain - - - 0.0000000000000000000000000000000000007136 159.0
TLS2_k127_2950445_26 Bacterial PH domain - - - 0.0000000000000000000000000000000003811 139.0
TLS2_k127_2950445_27 Protein of unknown function (DUF456) K09793 - - 0.00000000000000000004277 104.0
TLS2_k127_2950445_28 Protein of unknown function (DUF429) - - - 0.000000000000000002354 96.0
TLS2_k127_2950445_29 isomerase activity K07260 - 3.4.17.14 0.000000000000000005822 98.0
TLS2_k127_2950445_3 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 390.0
TLS2_k127_2950445_30 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 GO:0003674,GO:0003824,GO:0003872,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008443,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061615,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.11 0.0000000001808 66.0
TLS2_k127_2950445_31 - - - - 0.0000000188 61.0
TLS2_k127_2950445_4 Mur ligase family, glutamate ligase domain K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 360.0
TLS2_k127_2950445_5 ABC-type sugar transport system, permease component K10234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 354.0
TLS2_k127_2950445_6 ATP-grasp domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 346.0
TLS2_k127_2950445_7 COG1175 ABC-type sugar transport systems permease components K10233 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 340.0
TLS2_k127_2950445_8 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 355.0
TLS2_k127_2950445_9 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005863 326.0
TLS2_k127_296392_0 associated with various cellular activities K03696 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944 - 5.74e-267 836.0
TLS2_k127_296392_1 Chemotaxis protein CheA K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 392.0
TLS2_k127_296392_10 response regulator receiver K07658 - - 0.0000000000000000000001626 113.0
TLS2_k127_296392_11 Response regulator receiver domain - - - 0.00000000000000000004371 95.0
TLS2_k127_296392_12 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.00000000000000005933 92.0
TLS2_k127_296392_13 chemotaxis protein K03410 - - 0.0000000003465 68.0
TLS2_k127_296392_2 Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005102 273.0
TLS2_k127_296392_3 Belongs to the FPP GGPP synthase family K00805 - 2.5.1.30 0.0000000000000000000000000000000000000000000000000000000000000000002515 244.0
TLS2_k127_296392_4 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000004415 222.0
TLS2_k127_296392_5 CheR methyltransferase, all-alpha domain K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000001266 211.0
TLS2_k127_296392_6 PFAM surface presentation of antigens (SPOA) K02416 - - 0.00000000000000000000000000000000000002421 162.0
TLS2_k127_296392_7 response regulator K03413 - - 0.000000000000000000000000000000000001309 155.0
TLS2_k127_296392_8 Flagellar motor switch protein FliN K02417 GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0032879,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051270,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1902021,GO:2000145 - 0.00000000000000000000000000359 124.0
TLS2_k127_296392_9 PFAM CheW domain protein K03408 - - 0.00000000000000000000001822 112.0
TLS2_k127_2989835_0 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 513.0
TLS2_k127_2989835_1 COG1960 Acyl-CoA dehydrogenases K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 492.0
TLS2_k127_2989835_10 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001022 291.0
TLS2_k127_2989835_11 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007271 273.0
TLS2_k127_2989835_12 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000005217 196.0
TLS2_k127_2989835_13 - - - - 0.000000000000000000000000000000000000000000000000003953 194.0
TLS2_k127_2989835_14 - - - - 0.0000000000000000000000000000000000000000001108 171.0
TLS2_k127_2989835_15 Major facilitator Superfamily - - - 0.000000000000000000000000000000000007605 153.0
TLS2_k127_2989835_16 - - - - 0.0000000000000000000000000000000618 138.0
TLS2_k127_2989835_17 BetI-type transcriptional repressor, C-terminal - - - 0.0000000000000000000000000000001434 132.0
TLS2_k127_2989835_18 carboxylic ester hydrolase activity K03928 - 3.1.1.1 0.0000000000000000000005675 105.0
TLS2_k127_2989835_19 Fungalysin metallopeptidase (M36) - - - 0.000000000005319 68.0
TLS2_k127_2989835_2 CoA binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 489.0
TLS2_k127_2989835_20 D-alanyl-D-alanine carboxypeptidase K17733 - - 0.00000002072 65.0
TLS2_k127_2989835_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007337 436.0
TLS2_k127_2989835_4 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 407.0
TLS2_k127_2989835_5 Ring hydroxylating alpha subunit (catalytic domain) K00479 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 404.0
TLS2_k127_2989835_6 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 407.0
TLS2_k127_2989835_7 Putrescine transport system permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 338.0
TLS2_k127_2989835_8 Bacterial extracellular solute-binding protein K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 329.0
TLS2_k127_2989835_9 COG1177 ABC-type spermidine putrescine transport system, permease component II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005652 322.0
TLS2_k127_3004262_0 Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 601.0
TLS2_k127_3004262_1 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 580.0
TLS2_k127_3004262_10 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000001676 196.0
TLS2_k127_3004262_11 Domain of unknown function (DUF4386) - - - 0.000000000000000000000000000000000000000000000001044 188.0
TLS2_k127_3004262_12 regulation of cellular protein catabolic process - GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 - 0.000000000000000000000000000000000003053 144.0
TLS2_k127_3004262_13 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045926,GO:0048519,GO:0050789,GO:0065007,GO:0071944 - 0.000000000000000000000000000000000009045 141.0
TLS2_k127_3004262_14 - - - - 0.00000000000000000000000000002746 121.0
TLS2_k127_3004262_15 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000003578 113.0
TLS2_k127_3004262_16 ABC-2 family transporter protein - - - 0.00000000000000000000002278 113.0
TLS2_k127_3004262_17 Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000538 94.0
TLS2_k127_3004262_18 Copper binding proteins, plastocyanin/azurin family - - - 0.000000000000000001756 95.0
TLS2_k127_3004262_19 domain, Protein K07228 - - 0.0000000000000001443 82.0
TLS2_k127_3004262_2 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 433.0
TLS2_k127_3004262_20 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000000002026 90.0
TLS2_k127_3004262_21 - - - - 0.000000000003055 72.0
TLS2_k127_3004262_3 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 419.0
TLS2_k127_3004262_4 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 413.0
TLS2_k127_3004262_5 Voltage gated chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008537 331.0
TLS2_k127_3004262_6 Domain of unknown function (DUF4389) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005491 299.0
TLS2_k127_3004262_7 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001717 291.0
TLS2_k127_3004262_8 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003362 286.0
TLS2_k127_3004262_9 Domain of unknown function (DUF4386) - - - 0.000000000000000000000000000000000000000000000000000000000000002837 226.0
TLS2_k127_3024522_0 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 366.0
TLS2_k127_3024522_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 302.0
TLS2_k127_3024522_2 Flavin-binding monooxygenase-like K07222 - - 0.00000000000000000000000000000000000000000005994 169.0
TLS2_k127_3024522_3 LysM domain K03642,K03791,K22278 - 3.5.1.104 0.00001849 57.0
TLS2_k127_3151365_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1260.0
TLS2_k127_3151365_1 DNA polymerase alpha chain like domain K02337 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 0.0 1206.0
TLS2_k127_3151365_10 Cytidylyltransferase-like K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 452.0
TLS2_k127_3151365_11 MgsA AAA+ ATPase C terminal K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000579 436.0
TLS2_k127_3151365_12 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 414.0
TLS2_k127_3151365_13 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003436 415.0
TLS2_k127_3151365_14 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 405.0
TLS2_k127_3151365_15 4Fe-4S dicluster domain K00124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 411.0
TLS2_k127_3151365_16 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004885 391.0
TLS2_k127_3151365_17 NAD-dependent epimerase dehydratase K01710,K08678 - 4.1.1.35,4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 351.0
TLS2_k127_3151365_18 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 366.0
TLS2_k127_3151365_19 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 354.0
TLS2_k127_3151365_2 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1051.0
TLS2_k127_3151365_20 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 317.0
TLS2_k127_3151365_21 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 302.0
TLS2_k127_3151365_22 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000224 306.0
TLS2_k127_3151365_23 Protein of unknown function (DUF664) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008887 295.0
TLS2_k127_3151365_24 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000002491 262.0
TLS2_k127_3151365_25 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000007447 235.0
TLS2_k127_3151365_26 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000404 237.0
TLS2_k127_3151365_27 Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000009726 228.0
TLS2_k127_3151365_28 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000002501 194.0
TLS2_k127_3151365_29 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000002368 193.0
TLS2_k127_3151365_3 Carbamoyltransferase C-terminus K00612 - - 5.885e-236 743.0
TLS2_k127_3151365_30 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000001394 183.0
TLS2_k127_3151365_31 Predicted membrane protein (DUF2231) - - - 0.000000000000000000000000000000000000000000000003158 179.0
TLS2_k127_3151365_32 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000004047 186.0
TLS2_k127_3151365_33 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.00000000000000000000000000000000000000000000009315 171.0
TLS2_k127_3151365_34 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000006093 181.0
TLS2_k127_3151365_35 Rhomboid family K19225 - 3.4.21.105 0.000000000000000000000000000000000000000001514 179.0
TLS2_k127_3151365_36 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.00000000000000000000000000000000000000001669 158.0
TLS2_k127_3151365_37 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009378,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360 3.6.4.12 0.0000000000000000000000000000000000000001219 159.0
TLS2_k127_3151365_38 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000003519 162.0
TLS2_k127_3151365_39 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000115 117.0
TLS2_k127_3151365_4 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 2.61e-232 740.0
TLS2_k127_3151365_40 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000001149 120.0
TLS2_k127_3151365_41 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.4.23.36 0.000000000000000000000007229 113.0
TLS2_k127_3151365_42 Belongs to the CinA family - - - 0.0000000000000000000006242 103.0
TLS2_k127_3151365_43 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA K09772 - - 0.000000000000000000017 98.0
TLS2_k127_3151365_44 KR domain - - - 0.00000000000000000002357 107.0
TLS2_k127_3151365_45 TIGRFAM Sporulation protein YteA - - - 0.00000000000000436 79.0
TLS2_k127_3151365_46 Preprotein translocase subunit K03210 - - 0.00000000000432 70.0
TLS2_k127_3151365_47 Septum formation initiator K04074 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000002312 72.0
TLS2_k127_3151365_48 DUF167 K09131 - - 0.000000005087 64.0
TLS2_k127_3151365_49 Integral membrane protein K02221 - - 0.000002831 53.0
TLS2_k127_3151365_5 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 8.312e-221 713.0
TLS2_k127_3151365_50 Band 7 protein - - - 0.00001276 58.0
TLS2_k127_3151365_6 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 1.695e-212 678.0
TLS2_k127_3151365_7 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 591.0
TLS2_k127_3151365_8 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 554.0
TLS2_k127_3151365_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006089 542.0
TLS2_k127_3243222_0 PFAM Hydantoinase B oxoprolinase K01469,K01474 - 3.5.2.14,3.5.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006107 454.0
TLS2_k127_3243222_1 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 351.0
TLS2_k127_3243222_2 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000001402 177.0
TLS2_k127_3243222_3 Peptidase dimerisation domain K01438 - 3.5.1.16 0.0000000000861 73.0
TLS2_k127_3282863_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0 1335.0
TLS2_k127_3282863_1 Flavin containing amine oxidoreductase - - - 1.274e-267 845.0
TLS2_k127_3282863_3 Belongs to the FPP GGPP synthase family K13787,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 447.0
TLS2_k127_3282863_4 antibiotic biosynthesis - - - 0.0000000000000000004393 93.0
TLS2_k127_3282863_5 - - - - 0.0000000000004585 70.0
TLS2_k127_3282863_7 Short C-terminal domain - - - 0.000004617 50.0
TLS2_k127_3282863_8 metal ion transport - - - 0.0003343 52.0
TLS2_k127_3284597_0 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K03520 - 1.2.5.3 0.0 1131.0
TLS2_k127_3284597_1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 3.171e-248 780.0
TLS2_k127_3284597_10 xanthine dehydrogenase activity K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008708 275.0
TLS2_k127_3284597_11 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002909 260.0
TLS2_k127_3284597_12 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000009135 233.0
TLS2_k127_3284597_13 aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000005591 231.0
TLS2_k127_3284597_14 HNH nucleases - - - 0.00000000000000000000000000000000000000000000000000000000002733 232.0
TLS2_k127_3284597_15 - - - - 0.00000000000000000000000001292 117.0
TLS2_k127_3284597_16 PFAM Abortive infection protein - - - 0.00000000000000000000001325 112.0
TLS2_k127_3284597_17 Domain of unknown function (DUF1992) - - - 0.000000000000000000003089 94.0
TLS2_k127_3284597_18 - - - - 0.0000000016 67.0
TLS2_k127_3284597_19 Short C-terminal domain - - - 0.0000001391 55.0
TLS2_k127_3284597_2 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 514.0
TLS2_k127_3284597_20 - - - - 0.0000002407 61.0
TLS2_k127_3284597_3 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 529.0
TLS2_k127_3284597_4 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 456.0
TLS2_k127_3284597_5 Alpha/beta-hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 405.0
TLS2_k127_3284597_6 Glycine cleavage system T protein K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 350.0
TLS2_k127_3284597_7 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 343.0
TLS2_k127_3284597_8 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002928 323.0
TLS2_k127_3284597_9 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004049 278.0
TLS2_k127_3294362_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.0 1314.0
TLS2_k127_3294362_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 5.844e-283 889.0
TLS2_k127_3294362_10 Sigma-54 interaction domain K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 567.0
TLS2_k127_3294362_11 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008743 550.0
TLS2_k127_3294362_12 von Willebrand factor type A - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008441 551.0
TLS2_k127_3294362_13 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 513.0
TLS2_k127_3294362_14 Condensation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001591 246.0
TLS2_k127_3294362_15 NIF3 (NGG1p interacting factor 3) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000001281 238.0
TLS2_k127_3294362_16 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000003118 237.0
TLS2_k127_3294362_17 metal-dependent hydrolase with the TIM-barrel fold - - - 0.000000000000000000000000000000000000000000000000000000001008 213.0
TLS2_k127_3294362_18 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000261 205.0
TLS2_k127_3294362_19 Hydrolase of X-linked nucleoside diphosphate N terminal - - - 0.000000000000000000000000000000000000000000000000000004185 210.0
TLS2_k127_3294362_2 Belongs to the glycosyl hydrolase 57 family - - - 1.418e-275 875.0
TLS2_k127_3294362_20 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000000004219 178.0
TLS2_k127_3294362_21 Phosphatidylinositol - - - 0.00000000000000000000000000000000000000000000005704 184.0
TLS2_k127_3294362_22 Belongs to the SOS response-associated peptidase family - - - 0.00000000000000000000000000000000000000000000008132 190.0
TLS2_k127_3294362_24 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000003365 137.0
TLS2_k127_3294362_25 C4-type zinc ribbon domain K07164 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000009904 116.0
TLS2_k127_3294362_26 - - - - 0.0000000000000000000001436 108.0
TLS2_k127_3294362_3 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 2.86e-258 812.0
TLS2_k127_3294362_4 Condensation domain - - - 5.417e-239 803.0
TLS2_k127_3294362_5 Belongs to the GPI family K01810 - 5.3.1.9 3.149e-214 677.0
TLS2_k127_3294362_6 Alpha amylase, catalytic domain K06044 - 5.4.99.15 1.21e-199 653.0
TLS2_k127_3294362_7 Class II release factor RF3, C-terminal domain K02837 - - 1.824e-194 620.0
TLS2_k127_3294362_8 Domain of unknown function (DUF3459) K00700,K01236 - 2.4.1.18,3.2.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000672 597.0
TLS2_k127_3294362_9 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 584.0
TLS2_k127_3309363_0 Acyl-CoA dehydrogenase, C-terminal domain K09456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 609.0
TLS2_k127_3309363_1 PFAM major facilitator superfamily MFS_1 K08167 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005882 601.0
TLS2_k127_3309363_10 ABC transporter K15555 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001349 274.0
TLS2_k127_3309363_11 Capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004077 282.0
TLS2_k127_3309363_12 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000466 273.0
TLS2_k127_3309363_13 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000703 246.0
TLS2_k127_3309363_14 AAA domain, putative AbiEii toxin, Type IV TA system K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000007409 247.0
TLS2_k127_3309363_15 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000005318 254.0
TLS2_k127_3309363_16 permease K20469 - - 0.000000000000000000000000000000000000000000000000000000000000114 227.0
TLS2_k127_3309363_17 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000001656 201.0
TLS2_k127_3309363_18 - - - - 0.000000000000000000000000000000000000000000000000000001452 202.0
TLS2_k127_3309363_19 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000004038 193.0
TLS2_k127_3309363_2 Belongs to the aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 511.0
TLS2_k127_3309363_20 Histidine kinase - - - 0.000000000000000000000000000001951 141.0
TLS2_k127_3309363_21 lactoylglutathione lyase activity - - - 0.000000000000000000000000000002703 125.0
TLS2_k127_3309363_22 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.00000000000000000000000000006884 119.0
TLS2_k127_3309363_23 Flavin reductase like domain - - - 0.00000000000000000000000002254 128.0
TLS2_k127_3309363_24 Ferric uptake regulator family K03711 - - 0.0000000000000000000000003438 111.0
TLS2_k127_3309363_25 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000004533 79.0
TLS2_k127_3309363_26 Universal stress protein - - - 0.0000000006822 70.0
TLS2_k127_3309363_27 ABC transporter, phosphonate, periplasmic substrate-binding protein K15553 - - 0.0000008931 52.0
TLS2_k127_3309363_28 Redoxin K03564 - 1.11.1.15 0.0000023 59.0
TLS2_k127_3309363_3 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009486 438.0
TLS2_k127_3309363_4 TrkA-C domain K11105 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009154 440.0
TLS2_k127_3309363_5 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 385.0
TLS2_k127_3309363_6 catechol 1,2-dioxygenase K03381,K04098 - 1.13.11.1,1.13.11.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006753 370.0
TLS2_k127_3309363_7 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 312.0
TLS2_k127_3309363_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K15554 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 312.0
TLS2_k127_3309363_9 ABC 3 transport family K02075,K09819 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002467 279.0
TLS2_k127_332952_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 1.321e-226 722.0
TLS2_k127_332952_1 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000001256 280.0
TLS2_k127_332952_2 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000002985 256.0
TLS2_k127_332952_3 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000000000007923 219.0
TLS2_k127_332952_4 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K00950,K13940 - 2.7.6.3,4.1.2.25 0.000000000000000000000000000000001142 146.0
TLS2_k127_332952_5 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K00950,K13940 - 2.7.6.3,4.1.2.25 0.000000000000000000001648 101.0
TLS2_k127_332952_6 - - - - 0.000000000000000000002636 108.0
TLS2_k127_332952_7 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000001143 58.0
TLS2_k127_3389967_0 Hydrolase CocE NonD family K06978 - - 6.536e-255 836.0
TLS2_k127_3389967_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.717e-248 787.0
TLS2_k127_3389967_10 arylformamidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 340.0
TLS2_k127_3389967_11 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K19189 - 1.14.13.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009601 347.0
TLS2_k127_3389967_12 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 328.0
TLS2_k127_3389967_13 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 316.0
TLS2_k127_3389967_15 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 291.0
TLS2_k127_3389967_16 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001383 286.0
TLS2_k127_3389967_17 7TM receptor with intracellular HD hydrolase K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007843 302.0
TLS2_k127_3389967_18 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002626 278.0
TLS2_k127_3389967_19 Two component transcriptional regulator, winged helix family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004525 277.0
TLS2_k127_3389967_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 1.044e-210 681.0
TLS2_k127_3389967_20 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002277 265.0
TLS2_k127_3389967_21 Involved in the biosynthesis of porphyrin-containing compound - GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000003671 264.0
TLS2_k127_3389967_22 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000008895 259.0
TLS2_k127_3389967_23 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000003067 239.0
TLS2_k127_3389967_24 NPCBM-associated, NEW3 domain of alpha-galactosidase - - - 0.0000000000000000000000000000000000000000000000000000000000003176 228.0
TLS2_k127_3389967_25 membrane - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000003318 222.0
TLS2_k127_3389967_26 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000001006 225.0
TLS2_k127_3389967_27 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000001069 211.0
TLS2_k127_3389967_28 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000000006114 196.0
TLS2_k127_3389967_29 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000004262 142.0
TLS2_k127_3389967_3 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007843 478.0
TLS2_k127_3389967_30 Helix-hairpin-helix motif K02237 - - 0.0000000000000000000000000000007488 132.0
TLS2_k127_3389967_31 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000001153 118.0
TLS2_k127_3389967_32 ferredoxin K05337 - - 0.00000000000000000000001137 110.0
TLS2_k127_3389967_33 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000001238 111.0
TLS2_k127_3389967_34 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000004986 92.0
TLS2_k127_3389967_35 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000004647 96.0
TLS2_k127_3389967_36 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000006153 83.0
TLS2_k127_3389967_37 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.000000005228 69.0
TLS2_k127_3389967_38 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.0000001655 64.0
TLS2_k127_3389967_4 Histidinol dehydrogenase K00013,K15509 - 1.1.1.23,1.1.1.308 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000535 438.0
TLS2_k127_3389967_5 Amidohydrolase family K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 379.0
TLS2_k127_3389967_6 integral membrane sensor signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 376.0
TLS2_k127_3389967_7 phosphate starvation-inducible protein PhoH K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006315 362.0
TLS2_k127_3389967_8 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 372.0
TLS2_k127_3389967_9 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 349.0
TLS2_k127_3489660_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 610.0
TLS2_k127_3489660_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 552.0
TLS2_k127_3489660_10 Hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000003871 227.0
TLS2_k127_3489660_11 MASE1 - - - 0.0000000000000000000000000000000000000000000000009988 198.0
TLS2_k127_3489660_12 overlaps another CDS with the same product name K11472 - - 0.00000000000000000000000000000000000000000001649 177.0
TLS2_k127_3489660_13 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000225 123.0
TLS2_k127_3489660_14 PAS domain - - - 0.000000000000000000000003615 118.0
TLS2_k127_3489660_15 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000009031 116.0
TLS2_k127_3489660_16 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000006929 115.0
TLS2_k127_3489660_17 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000001355 108.0
TLS2_k127_3489660_18 - - - - 0.000000000000000000001119 107.0
TLS2_k127_3489660_19 - - - - 0.00000000000000000146 89.0
TLS2_k127_3489660_2 dehydrogenase, E1 component K11381 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002674 541.0
TLS2_k127_3489660_20 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.00000000000000007373 89.0
TLS2_k127_3489660_21 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 0.0000000001452 67.0
TLS2_k127_3489660_22 - K01992 - - 0.00009721 55.0
TLS2_k127_3489660_3 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 517.0
TLS2_k127_3489660_4 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 509.0
TLS2_k127_3489660_5 Belongs to the amidase family K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 438.0
TLS2_k127_3489660_6 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 345.0
TLS2_k127_3489660_7 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005922 291.0
TLS2_k127_3489660_8 COG0500 SAM-dependent methyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001005 265.0
TLS2_k127_3489660_9 Fe-S oxidoreductase K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001177 273.0
TLS2_k127_3619794_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 1.613e-218 713.0
TLS2_k127_3619794_1 UDP binding domain K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003303 406.0
TLS2_k127_3619794_2 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000002621 263.0
TLS2_k127_3619794_3 F420-0:Gamma-glutamyl ligase K12234 GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000004204 244.0
TLS2_k127_3619794_4 - - - - 0.00000000000000000000000000000000000000000000000000000006062 203.0
TLS2_k127_3619794_5 LytR cell envelope-related transcriptional attenuator - - - 0.000000000000000000000000000000000000000000000000000004957 208.0
TLS2_k127_3619794_6 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000201 196.0
TLS2_k127_3619794_7 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.0000000000000000009851 94.0
TLS2_k127_3619794_8 Dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000001373 82.0
TLS2_k127_3619794_9 Non-essential cell division protein that could be required for efficient cell constriction - - - 0.000007673 59.0
TLS2_k127_3645001_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.379e-239 751.0
TLS2_k127_3645001_1 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009166 395.0
TLS2_k127_3645001_10 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000002535 157.0
TLS2_k127_3645001_11 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family K16048 - - 0.0000000000000000000000000000000000001599 162.0
TLS2_k127_3645001_12 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000003776 102.0
TLS2_k127_3645001_13 Cupin domain - - - 0.00000003304 66.0
TLS2_k127_3645001_14 NMT1-like family K02051,K15553 - - 0.0000001515 63.0
TLS2_k127_3645001_15 Major facilitator Superfamily - - - 0.0001343 50.0
TLS2_k127_3645001_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 305.0
TLS2_k127_3645001_3 Amidohydrolase family K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 309.0
TLS2_k127_3645001_4 ABC transporter K02049,K10831 GO:0003674,GO:0003824,GO:0005215,GO:0005342,GO:0005368,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0008559,GO:0015075,GO:0015238,GO:0015399,GO:0015405,GO:0015411,GO:0015711,GO:0015734,GO:0015849,GO:0015893,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033283,GO:0034220,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042908,GO:0042910,GO:0043492,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072348,GO:0098656,GO:1901682,GO:1903825 3.6.3.36 0.00000000000000000000000000000000000000000000000000000000000000000007579 251.0
TLS2_k127_3645001_5 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000004388 204.0
TLS2_k127_3645001_6 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000003804 209.0
TLS2_k127_3645001_7 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000007291 179.0
TLS2_k127_3645001_8 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000004833 187.0
TLS2_k127_3645001_9 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.000000000000000000000000000000000000000001677 175.0
TLS2_k127_3679491_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005807 430.0
TLS2_k127_3679491_1 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 351.0
TLS2_k127_3679491_2 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 359.0
TLS2_k127_3679491_3 COG0433 Predicted ATPase K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007862 321.0
TLS2_k127_3679491_4 PFAM Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005362 263.0
TLS2_k127_3679491_5 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000001649 178.0
TLS2_k127_3679491_6 EamA-like transporter family - - - 0.00000000000000000000000000000000000001421 154.0
TLS2_k127_3679491_7 COG1525 Micrococcal nuclease (thermonuclease) homologs K01174 - 3.1.31.1 0.000000000000000001001 102.0
TLS2_k127_3724846_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003212 388.0
TLS2_k127_3724846_1 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019693,GO:0019752,GO:0020037,GO:0022607,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 316.0
TLS2_k127_3724846_2 helix_turn_helix, mercury resistance K13640 - - 0.00000000000000000000000000000008463 129.0
TLS2_k127_3724846_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000001661 121.0
TLS2_k127_3724846_4 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000002612 115.0
TLS2_k127_3724846_5 Lysyl oxidase K00277,K00280 GO:0000122,GO:0000785,GO:0001525,GO:0001568,GO:0001666,GO:0001667,GO:0001837,GO:0001935,GO:0001944,GO:0002040,GO:0003674,GO:0003824,GO:0004720,GO:0005488,GO:0005507,GO:0005509,GO:0005575,GO:0005576,GO:0005604,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005783,GO:0006091,GO:0006325,GO:0006355,GO:0006357,GO:0006464,GO:0006807,GO:0006928,GO:0006950,GO:0006996,GO:0007155,GO:0007275,GO:0007568,GO:0008150,GO:0008152,GO:0008283,GO:0009055,GO:0009628,GO:0009653,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010631,GO:0010717,GO:0010718,GO:0012505,GO:0016043,GO:0016477,GO:0016491,GO:0016638,GO:0016641,GO:0018057,GO:0018158,GO:0018193,GO:0018205,GO:0019219,GO:0019222,GO:0019538,GO:0022610,GO:0022900,GO:0030154,GO:0030198,GO:0030199,GO:0030246,GO:0031012,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031974,GO:0031981,GO:0032330,GO:0032332,GO:0032501,GO:0032502,GO:0035239,GO:0035295,GO:0036211,GO:0036293,GO:0040011,GO:0042221,GO:0043062,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043542,GO:0043933,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044421,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0045597,GO:0045892,GO:0045934,GO:0046688,GO:0046872,GO:0046914,GO:0048513,GO:0048514,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048646,GO:0048731,GO:0048762,GO:0048856,GO:0048869,GO:0048870,GO:0050673,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051093,GO:0051094,GO:0051171,GO:0051172,GO:0051179,GO:0051239,GO:0051240,GO:0051241,GO:0051252,GO:0051253,GO:0051276,GO:0051674,GO:0055114,GO:0060255,GO:0060485,GO:0061035,GO:0061036,GO:0062023,GO:0065007,GO:0070013,GO:0070482,GO:0070492,GO:0070828,GO:0071704,GO:0071840,GO:0072358,GO:0072359,GO:0080090,GO:0090130,GO:0090132,GO:0097435,GO:0140096,GO:1901564,GO:1902455,GO:1902679,GO:1903506,GO:1903507,GO:2000026,GO:2000036,GO:2000112,GO:2000113,GO:2001141 1.4.3.13 0.00000001799 67.0
TLS2_k127_3724846_6 Hint domain - - - 0.0001723 54.0
TLS2_k127_3775677_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812,K08351 - 1.7.2.3 2.954e-293 930.0
TLS2_k127_3775677_1 Trimethylamine methyltransferase (MTTB) - - - 1.039e-205 662.0
TLS2_k127_3775677_10 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 305.0
TLS2_k127_3775677_11 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003431 296.0
TLS2_k127_3775677_12 ABC transporter K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000000001313 258.0
TLS2_k127_3775677_13 protein containing SIS (Sugar isomerase) phosphosugar binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000003008 228.0
TLS2_k127_3775677_14 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000061 223.0
TLS2_k127_3775677_15 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360 2.1.1.198 0.00000000000000000000000000000000000000000000000000000001353 216.0
TLS2_k127_3775677_16 Uncharacterised protein family UPF0047 - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000003816 196.0
TLS2_k127_3775677_17 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000005863 200.0
TLS2_k127_3775677_18 Protein of unknown function (DUF3152) - - - 0.00000000000000000000000000000000000000000000000005312 193.0
TLS2_k127_3775677_19 TatD related DNase K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000000000006364 183.0
TLS2_k127_3775677_2 sugar-specific permease SgaT UlaA K03475 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 582.0
TLS2_k127_3775677_20 MobA-like NTP transferase domain K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000204 183.0
TLS2_k127_3775677_21 PFAM Translin K07477 - - 0.00000000000000000000000000000000000000000006778 167.0
TLS2_k127_3775677_22 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000001055 160.0
TLS2_k127_3775677_23 Zn peptidase - - - 0.000000000000000000000000000000000000000008764 170.0
TLS2_k127_3775677_24 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000212 164.0
TLS2_k127_3775677_25 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000004557 161.0
TLS2_k127_3775677_26 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000005622 149.0
TLS2_k127_3775677_27 PIN domain - - - 0.0000000000000000000000000000000003027 136.0
TLS2_k127_3775677_28 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02821 - 2.7.1.194 0.0000000000000000000000000000002822 134.0
TLS2_k127_3775677_29 phosphoprotein phosphatase activity - - - 0.000000000000000000000000000003967 132.0
TLS2_k127_3775677_3 Belongs to the TPP enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 431.0
TLS2_k127_3775677_30 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000001002 125.0
TLS2_k127_3775677_31 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity K02822 - 2.7.1.194 0.0000000000000000000000004247 122.0
TLS2_k127_3775677_32 Putative regulatory protein - - - 0.000000000000000005611 88.0
TLS2_k127_3775677_33 Transcriptional regulator, AbrB family K06284 - - 0.00000000000000001063 86.0
TLS2_k127_3775677_34 - - - - 0.000000000000000671 87.0
TLS2_k127_3775677_35 Major Facilitator Superfamily - - - 0.00000000000000103 80.0
TLS2_k127_3775677_36 Polymer-forming cytoskeletal - - - 0.000000000000001104 90.0
TLS2_k127_3775677_37 Major Facilitator Superfamily - - - 0.00000000001019 73.0
TLS2_k127_3775677_38 - - - - 0.0000000002302 72.0
TLS2_k127_3775677_39 Evidence 2b Function of strongly homologous gene K07171 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.0000000002756 68.0
TLS2_k127_3775677_4 Phenazine biosynthesis-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 391.0
TLS2_k127_3775677_41 Protein of unknown function (DUF3107) - - - 0.00000002161 57.0
TLS2_k127_3775677_42 Uncharacterized ACR, COG1430 K09005 - - 0.000001924 54.0
TLS2_k127_3775677_43 PFAM Peptidoglycan-binding lysin domain - - - 0.00001675 55.0
TLS2_k127_3775677_44 - - - - 0.0009997 50.0
TLS2_k127_3775677_5 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004709 387.0
TLS2_k127_3775677_6 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 350.0
TLS2_k127_3775677_7 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006326 358.0
TLS2_k127_3775677_8 SIS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003034 336.0
TLS2_k127_3775677_9 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003022 311.0
TLS2_k127_3857355_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 4.903e-275 858.0
TLS2_k127_3857355_1 PFAM phenylalanine histidine ammonia-lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 593.0
TLS2_k127_3857355_10 Binding-protein-dependent transport system inner membrane component K02025,K05814 - - 0.000000000000000000000000000000000000002388 160.0
TLS2_k127_3857355_11 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000005045 134.0
TLS2_k127_3857355_12 - - - - 0.0000000000000000005508 89.0
TLS2_k127_3857355_13 Cupin domain - - - 0.000000000000000003813 97.0
TLS2_k127_3857355_14 OsmC-like protein - - - 0.0000000004938 63.0
TLS2_k127_3857355_15 Bacterial extracellular solute-binding protein K02027 - - 0.0000000385 66.0
TLS2_k127_3857355_16 Luciferase-like monooxygenase - - - 0.00000006845 58.0
TLS2_k127_3857355_2 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008567 429.0
TLS2_k127_3857355_3 Imidazolone-5-propionate hydrolase K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 379.0
TLS2_k127_3857355_4 nucleoside 2-deoxyribosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001675 244.0
TLS2_k127_3857355_5 Na+/Pi-cotransporter - - - 0.00000000000000000000000000000000000000000000000000000000000001787 229.0
TLS2_k127_3857355_6 Amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000000000000000000000000000000000000009122 225.0
TLS2_k127_3857355_7 ABC-type sugar transport system, permease component K02026 - - 0.000000000000000000000000000000000000000000000000000008389 211.0
TLS2_k127_3857355_8 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000005515 198.0
TLS2_k127_3857355_9 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000001433 184.0
TLS2_k127_3858708_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007585 474.0
TLS2_k127_3858708_1 F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003594 388.0
TLS2_k127_3858708_2 Dipeptidyl aminopeptidase acylaminoacyl peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006786 383.0
TLS2_k127_3858708_3 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000001873 229.0
TLS2_k127_3858708_4 Appr-1'-p processing enzyme - GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231 - 0.0000000000000000000000000000000000000000000000000000000912 201.0
TLS2_k127_3858708_5 Domain of unknown function (DUF2383) - - - 0.00000000000000000000000006134 110.0
TLS2_k127_3858708_6 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000007469 76.0
TLS2_k127_3858708_7 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000403 73.0
TLS2_k127_3858708_8 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568 2.7.7.68 0.0000000001476 71.0
TLS2_k127_3894785_0 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 602.0
TLS2_k127_3894785_1 transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 432.0
TLS2_k127_3894785_10 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000005365 241.0
TLS2_k127_3894785_11 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000000006824 246.0
TLS2_k127_3894785_12 cell redox homeostasis K02199 - - 0.00000000000000000000000000000000000000000000002848 186.0
TLS2_k127_3894785_13 Acetyltransferase (GNAT) domain K03829 - - 0.000000000000000000000000000000000000000000007853 170.0
TLS2_k127_3894785_14 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000003418 173.0
TLS2_k127_3894785_15 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000003932 172.0
TLS2_k127_3894785_16 Histidine kinase - - - 0.00000000000000000000000000000000000000007089 166.0
TLS2_k127_3894785_17 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000000002502 159.0
TLS2_k127_3894785_18 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02193,K02194 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 0.0000000000000000000000000000001512 142.0
TLS2_k127_3894785_19 Ferric uptake regulator family K03711 - - 0.0000000000000000000003142 111.0
TLS2_k127_3894785_2 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003512 421.0
TLS2_k127_3894785_20 Endoribonuclease L-PSP - - - 0.000000000000000000002268 100.0
TLS2_k127_3894785_22 domain protein K07154 - 2.7.11.1 0.0000000000000002716 81.0
TLS2_k127_3894785_23 subunit of a heme lyase K02200 - - 0.000000000000002215 82.0
TLS2_k127_3894785_24 subunit of a heme lyase - - - 0.000000000000002942 87.0
TLS2_k127_3894785_25 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000001079 81.0
TLS2_k127_3894785_26 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000002424 74.0
TLS2_k127_3894785_27 - - - - 0.000000001065 66.0
TLS2_k127_3894785_29 sequence-specific DNA binding - - - 0.00009953 48.0
TLS2_k127_3894785_3 Part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 336.0
TLS2_k127_3894785_30 Protein of unknown function (DUF541) K09807 - - 0.0004016 49.0
TLS2_k127_3894785_31 Thioredoxin K02199 - - 0.0007066 46.0
TLS2_k127_3894785_4 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 330.0
TLS2_k127_3894785_5 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 290.0
TLS2_k127_3894785_6 HipA domain protein K07154 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001429 285.0
TLS2_k127_3894785_7 Bacterial extracellular solute-binding protein K10232 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000413 299.0
TLS2_k127_3894785_8 Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000000001094 242.0
TLS2_k127_3894785_9 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000008645 249.0
TLS2_k127_3896579_0 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 596.0
TLS2_k127_3896579_1 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007088 567.0
TLS2_k127_3896579_10 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 331.0
TLS2_k127_3896579_11 helix_turn _helix lactose operon repressor K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 322.0
TLS2_k127_3896579_12 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001211 289.0
TLS2_k127_3896579_13 helix_turn _helix lactose operon repressor K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002469 287.0
TLS2_k127_3896579_14 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000007202 274.0
TLS2_k127_3896579_15 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000003862 253.0
TLS2_k127_3896579_16 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000001693 242.0
TLS2_k127_3896579_17 Cysteine-rich domain K18928 - - 0.00000000000000000000000000000000000000000000000000000000000000161 235.0
TLS2_k127_3896579_18 ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000000000000008763 233.0
TLS2_k127_3896579_19 - - - - 0.000000000000000000000000000000000000000000000000000000000003561 217.0
TLS2_k127_3896579_2 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 467.0
TLS2_k127_3896579_20 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000006946 227.0
TLS2_k127_3896579_21 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000001489 219.0
TLS2_k127_3896579_22 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000005908 213.0
TLS2_k127_3896579_23 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07032 - - 0.000000000000000000000000000000000000000000000000000003518 193.0
TLS2_k127_3896579_24 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000000000000000000000004682 209.0
TLS2_k127_3896579_25 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.0000000000000000000000000000000000000000000000001267 191.0
TLS2_k127_3896579_26 PFAM Creatininase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000005175 194.0
TLS2_k127_3896579_27 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.000000000000000000000000000000000000000000000001302 190.0
TLS2_k127_3896579_28 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000001089 166.0
TLS2_k127_3896579_29 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000001098 164.0
TLS2_k127_3896579_3 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 429.0
TLS2_k127_3896579_30 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000004593 141.0
TLS2_k127_3896579_31 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000001962 141.0
TLS2_k127_3896579_32 Alpha/beta hydrolase of unknown function (DUF1100) - GO:0006582,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009987,GO:0018958,GO:0019438,GO:0019748,GO:0030638,GO:0030640,GO:0042438,GO:0042440,GO:0044237,GO:0044249,GO:0044550,GO:0046148,GO:0046189,GO:0071704,GO:0090487,GO:1901360,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901617 - 0.00000000000000000000000000001654 132.0
TLS2_k127_3896579_33 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000005221 128.0
TLS2_k127_3896579_34 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10794 - 1.21.4.1 0.00000000000000000000000001473 116.0
TLS2_k127_3896579_35 SnoaL-like polyketide cyclase - - - 0.000000000000000000000002024 120.0
TLS2_k127_3896579_36 LUD domain K00782 - - 0.0000000000000000000006282 109.0
TLS2_k127_3896579_37 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - 0.00000000000000002959 84.0
TLS2_k127_3896579_38 Belongs to the 'phage' integrase family - - - 0.0000000000001002 76.0
TLS2_k127_3896579_4 Amino acid dehydrogenase K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 421.0
TLS2_k127_3896579_40 Major Facilitator Superfamily - - - 0.00000001084 67.0
TLS2_k127_3896579_41 Transporter - - - 0.00000004673 64.0
TLS2_k127_3896579_42 Cupin 2, conserved barrel domain protein - - - 0.00000015 64.0
TLS2_k127_3896579_43 - - - - 0.000000628 56.0
TLS2_k127_3896579_44 NADPH quinone K00344 - 1.6.5.5 0.00008235 46.0
TLS2_k127_3896579_5 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 370.0
TLS2_k127_3896579_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 385.0
TLS2_k127_3896579_7 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 347.0
TLS2_k127_3896579_8 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 347.0
TLS2_k127_3896579_9 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 321.0
TLS2_k127_3900555_0 helicase activity - - - 5.329e-228 731.0
TLS2_k127_3900555_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 533.0
TLS2_k127_3900555_10 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000000000000000000000001637 115.0
TLS2_k127_3900555_11 Protein of unknown function (DUF3618) - - - 0.000000000000000003157 92.0
TLS2_k127_3900555_12 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.000000000000000005753 92.0
TLS2_k127_3900555_2 amino acid K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 470.0
TLS2_k127_3900555_3 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 407.0
TLS2_k127_3900555_4 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 411.0
TLS2_k127_3900555_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K15553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 325.0
TLS2_k127_3900555_6 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003495 310.0
TLS2_k127_3900555_7 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001487 272.0
TLS2_k127_3900555_8 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002454 264.0
TLS2_k127_3900555_9 YCII-related domain - - - 0.0000000000000000000000000000000000000000004687 160.0
TLS2_k127_3911312_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 622.0
TLS2_k127_3911312_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 536.0
TLS2_k127_3911312_10 Flagellar basal body rod FlgEFG protein C-terminal K02396 - - 0.000000000000000000000000000000000000000000000000000000000000000009814 245.0
TLS2_k127_3911312_11 MotA/TolQ/ExbB proton channel family K02556 - - 0.000000000000000000000000000000000000000000000000000000000009122 216.0
TLS2_k127_3911312_12 PFAM Flagellar motor switch protein FliG K02410 - - 0.00000000000000000000000000000000000000000000000000000005763 208.0
TLS2_k127_3911312_13 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000004632 194.0
TLS2_k127_3911312_14 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.0000000000000000000000000000000000000000000000007634 194.0
TLS2_k127_3911312_15 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000000000000000003738 188.0
TLS2_k127_3911312_16 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K02405 - - 0.00000000000000000000000000000000000000000000319 181.0
TLS2_k127_3911312_17 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.000000000000000000000000000000000000000101 171.0
TLS2_k127_3911312_18 Flagellar motor protein K02557 - - 0.000000000000000000000000000000000000007927 162.0
TLS2_k127_3911312_19 Bacterial flagellin N-terminal helical region K02397 - - 0.0000000000000000000000000000002379 134.0
TLS2_k127_3911312_2 ATP synthase alpha/beta family, nucleotide-binding domain K02412 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 441.0
TLS2_k127_3911312_20 Flagellar basal body rod FlgEFG protein C-terminal K02388 - - 0.000000000000000000000000000002873 131.0
TLS2_k127_3911312_21 Transglycosylase SLT domain - - - 0.00000000000000000000000002725 120.0
TLS2_k127_3911312_22 - K01992 - - 0.000000000000000000000005032 111.0
TLS2_k127_3911312_23 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.00000000000000000000004579 105.0
TLS2_k127_3911312_24 Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum K13626 - - 0.000000000000000000001089 101.0
TLS2_k127_3911312_25 Flagellar hook capping protein K02389 - - 0.000000000000000000005295 101.0
TLS2_k127_3911312_26 Flagellar protein FliS K02422 - - 0.000000000000000001211 93.0
TLS2_k127_3911312_27 flagellar biosynthetic protein FliR K02421 - - 0.000000000000000001897 95.0
TLS2_k127_3911312_28 23S rRNA-intervening sequence protein - - - 0.0000000000000003039 87.0
TLS2_k127_3911312_29 Global regulator protein family K03563 - - 0.000000000000002941 84.0
TLS2_k127_3911312_3 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005965 406.0
TLS2_k127_3911312_30 Bacterial export proteins, family 3 K02420 - - 0.00000000000007934 83.0
TLS2_k127_3911312_31 Flagellar protein (FlbD) K02385 - - 0.0000000000002072 74.0
TLS2_k127_3911312_32 FlgN protein - - - 0.0000000000005587 76.0
TLS2_k127_3911312_33 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.000000000006612 71.0
TLS2_k127_3911312_34 Flagellar hook-basal body K02408 - - 0.000000005035 63.0
TLS2_k127_3911312_35 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.000000009478 66.0
TLS2_k127_3911312_36 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02417 - - 0.00000003949 64.0
TLS2_k127_3911312_37 Membrane - - - 0.00000005301 63.0
TLS2_k127_3911312_38 flagellar assembly protein FliH K02411 - - 0.000001722 59.0
TLS2_k127_3911312_4 Flagella basal body rod protein K02390 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 394.0
TLS2_k127_3911312_40 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.000005534 57.0
TLS2_k127_3911312_41 Flagellar biosynthesis protein, FliO K02418 - - 0.00007976 50.0
TLS2_k127_3911312_42 PFAM EAL domain - - - 0.0001857 51.0
TLS2_k127_3911312_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 291.0
TLS2_k127_3911312_6 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001757 285.0
TLS2_k127_3911312_7 The M ring may be actively involved in energy transduction K02409 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001254 290.0
TLS2_k127_3911312_8 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001565 273.0
TLS2_k127_3911312_9 Plays a role in the flagellum-specific transport system K02419 - - 0.0000000000000000000000000000000000000000000000000000000000000000004914 237.0
TLS2_k127_3953584_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.4.4.2 0.0 1138.0
TLS2_k127_3953584_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1116.0
TLS2_k127_3953584_10 NADPH quinone reductase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 298.0
TLS2_k127_3953584_11 pfkB family carbohydrate kinase K00882 - 2.7.1.56 0.000000000000000000000000000000000000000000000000000000000000000000000456 248.0
TLS2_k127_3953584_12 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate K00598 - 2.1.1.144 0.0000000000000000000000000000000000000000000000000000000000000000007125 236.0
TLS2_k127_3953584_13 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000003215 209.0
TLS2_k127_3953584_14 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000001675 196.0
TLS2_k127_3953584_15 MgtC family K07507 - - 0.0000000000000000000000000000000000000000000000000006345 193.0
TLS2_k127_3953584_16 survival protein SurE K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000002501 190.0
TLS2_k127_3953584_17 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000000002527 181.0
TLS2_k127_3953584_18 Short repeat of unknown function (DUF308) - - - 0.000000000000000000000000000000000000000000000003986 179.0
TLS2_k127_3953584_19 SufE protein probably involved in Fe-S center assembly K02426 - - 0.0000000000000000000000000000000000000000000004518 170.0
TLS2_k127_3953584_2 Transport of potassium into the cell K03549 - - 1.193e-227 721.0
TLS2_k127_3953584_20 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.0000000000000000000000000000000000000000005602 165.0
TLS2_k127_3953584_21 isoleucine patch - - - 0.0000000000000000000000000000000000008667 156.0
TLS2_k127_3953584_22 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.00000000000000000000000000000000002411 147.0
TLS2_k127_3953584_23 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding - - - 0.00000000000000000000744 100.0
TLS2_k127_3953584_24 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding - - - 0.000000000000000001368 95.0
TLS2_k127_3953584_25 COG2010 Cytochrome c, mono- and diheme variants K12263,K13300 - - 0.000000001964 62.0
TLS2_k127_3953584_26 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.0000005986 58.0
TLS2_k127_3953584_27 argininosuccinate lyase activity K01755 - 4.3.2.1 0.000008244 55.0
TLS2_k127_3953584_28 helix_turn_helix, mercury resistance - - - 0.00001881 53.0
TLS2_k127_3953584_29 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.00003184 54.0
TLS2_k127_3953584_3 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007826 496.0
TLS2_k127_3953584_4 Sulfurtransferase K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 451.0
TLS2_k127_3953584_5 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 467.0
TLS2_k127_3953584_6 chorismate binding enzyme K02361,K02552 - 5.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 343.0
TLS2_k127_3953584_7 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 GO:0008150,GO:0040007 4.2.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 332.0
TLS2_k127_3953584_8 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 348.0
TLS2_k127_3953584_9 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 299.0
TLS2_k127_3963065_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 3.974e-196 623.0
TLS2_k127_3963065_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 531.0
TLS2_k127_3963065_2 Right handed beta helix region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007601 508.0
TLS2_k127_3963065_3 COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 413.0
TLS2_k127_3963065_4 N-acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001103 254.0
TLS2_k127_3963065_5 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000003003 153.0
TLS2_k127_3963065_6 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000002769 118.0
TLS2_k127_3963065_7 Scaffold protein Nfu NifU - - - 0.000000000004321 70.0
TLS2_k127_3971105_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 427.0
TLS2_k127_3971105_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004803 273.0
TLS2_k127_3971105_2 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001425 286.0
TLS2_k127_3971105_3 Forms part of the polypeptide exit tunnel K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000009155 236.0
TLS2_k127_3971105_4 Ribosomal protein S10p/S20e K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000001665 164.0
TLS2_k127_3971105_5 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000005003 161.0
TLS2_k127_3971105_6 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000000009442 138.0
TLS2_k127_3971105_7 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000002219 122.0
TLS2_k127_3971105_8 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0019899,GO:0030312,GO:0035375,GO:0036293,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.000000000002069 66.0
TLS2_k127_409104_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 557.0
TLS2_k127_409104_1 PFAM peptidase C45 acyl-coenzyme A 6-aminopenicillanic acid acyl-transferase K19200 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 372.0
TLS2_k127_409104_2 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000002758 194.0
TLS2_k127_409104_3 helix_turn_helix ASNC type K03718 - - 0.00000000000000000000000000000000000000000000000223 178.0
TLS2_k127_409104_4 Domain of unknown function (DUF4349) - - - 0.000000000000000000000000000000001694 147.0
TLS2_k127_410610_0 helix_turn_helix, Lux Regulon - - - 1.547e-319 1001.0
TLS2_k127_410610_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 8.319e-288 898.0
TLS2_k127_410610_10 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 420.0
TLS2_k127_410610_11 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 420.0
TLS2_k127_410610_12 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 344.0
TLS2_k127_410610_13 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005614 349.0
TLS2_k127_410610_14 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 349.0
TLS2_k127_410610_15 SAICAR synthetase K01923,K01945 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 313.0
TLS2_k127_410610_16 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003364 293.0
TLS2_k127_410610_17 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001501 301.0
TLS2_k127_410610_18 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006947 280.0
TLS2_k127_410610_19 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005598 289.0
TLS2_k127_410610_2 ABC-type multidrug transport system, ATPase and permease K06147 - - 1.221e-263 859.0
TLS2_k127_410610_20 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001308 269.0
TLS2_k127_410610_21 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003509 276.0
TLS2_k127_410610_22 Four helix bundle sensory module for signal transduction K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001996 277.0
TLS2_k127_410610_23 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000001195 261.0
TLS2_k127_410610_24 NADPH quinone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001574 251.0
TLS2_k127_410610_25 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000001093 244.0
TLS2_k127_410610_26 PAC2 family - - - 0.000000000000000000000000000000000000000000000000000000000000000003226 235.0
TLS2_k127_410610_27 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000002 233.0
TLS2_k127_410610_28 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000002767 231.0
TLS2_k127_410610_29 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000388 226.0
TLS2_k127_410610_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 5.518e-222 717.0
TLS2_k127_410610_30 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000007094 228.0
TLS2_k127_410610_31 metal-dependent hydrolase with the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000006611 233.0
TLS2_k127_410610_32 Inositol monophosphatase family K01092 GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 0.000000000000000000000000000000000000000000000000000000003215 209.0
TLS2_k127_410610_33 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000001236 211.0
TLS2_k127_410610_34 HAD-superfamily hydrolase, subfamily IA, variant 2 (HAD-like) K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000309 189.0
TLS2_k127_410610_35 mannose-6-phosphate isomerase K01809 - 5.3.1.8 0.0000000000000000000000000000000000000000000000004153 193.0
TLS2_k127_410610_36 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000000000000000000000002337 181.0
TLS2_k127_410610_37 Sugar (and other) transporter K18935 - - 0.00000000000000000000000000000000000000000008414 178.0
TLS2_k127_410610_38 PIN domain - - - 0.000000000000000000000000000000000000000002264 159.0
TLS2_k127_410610_39 AI-2E family transporter - - - 0.0000000000000000000000000000000000000008851 170.0
TLS2_k127_410610_4 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K12954,K12956,K17686,K21887 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009405,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0042221,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0050896,GO:0051704,GO:0071944 3.6.3.4,3.6.3.54 9.556e-205 662.0
TLS2_k127_410610_40 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.000000000000000000000000000000000001385 150.0
TLS2_k127_410610_41 - - - - 0.00000000000000000000000000000000009846 140.0
TLS2_k127_410610_42 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000002589 129.0
TLS2_k127_410610_43 Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region K21600 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010272,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042221,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046688,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097077,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000001254 120.0
TLS2_k127_410610_44 Cell envelope-related transcriptional attenuator domain - - - 0.0000000000000000000000000005419 126.0
TLS2_k127_410610_45 Nitroreductase family - - - 0.000000000000000000000000001477 119.0
TLS2_k127_410610_46 peroxiredoxin activity K03564,K07638 - 1.11.1.15,2.7.13.3 0.0000000000000000000000002532 115.0
TLS2_k127_410610_47 - - - - 0.00000000000000000000000506 115.0
TLS2_k127_410610_48 CoA-binding domain protein K06929 - - 0.00000000000000000000008239 107.0
TLS2_k127_410610_49 phenylacetic acid degradation protein PaaD K02614 GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790 - 0.0000000000000000001092 94.0
TLS2_k127_410610_5 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 597.0
TLS2_k127_410610_50 Domain of unknown function (DUF4386) - - - 0.00000000000002961 84.0
TLS2_k127_410610_51 Heavy-metal-associated domain K07213 - - 0.0000000000003304 76.0
TLS2_k127_410610_52 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000007158 80.0
TLS2_k127_410610_53 Carboxymuconolactone decarboxylase family - - - 0.000000000000976 71.0
TLS2_k127_410610_55 toxin-antitoxin pair type II binding - - - 0.00002784 57.0
TLS2_k127_410610_56 helix_turn_helix multiple antibiotic resistance protein K06075 - - 0.0001095 50.0
TLS2_k127_410610_6 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 518.0
TLS2_k127_410610_7 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005039 462.0
TLS2_k127_410610_8 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005893 441.0
TLS2_k127_410610_9 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 430.0
TLS2_k127_4134472_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 7.279e-238 757.0
TLS2_k127_4134472_1 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008676 433.0
TLS2_k127_4134472_10 Iron-containing redox enzyme - - - 0.000000000000000000000000000000000008589 147.0
TLS2_k127_4134472_11 WD-40 repeat-containing protein K12132 - 2.7.11.1 0.0000000000000000000000000000353 132.0
TLS2_k127_4134472_12 Transcriptional regulator - - - 0.00000000000000000000000000006781 120.0
TLS2_k127_4134472_13 Stage II sporulation protein E (SpoIIE) - - - 0.0000000000000008313 82.0
TLS2_k127_4134472_14 STAS domain K06378 - - 0.00000000001975 72.0
TLS2_k127_4134472_15 Universal stress protein - - - 0.00000004849 63.0
TLS2_k127_4134472_16 Anti-sigma-K factor rskA - - - 0.0000004425 61.0
TLS2_k127_4134472_17 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.0000005519 57.0
TLS2_k127_4134472_18 protein phosphatase 2C domain protein - - - 0.0001404 53.0
TLS2_k127_4134472_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648,K18003 - 2.3.1.180,2.3.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 347.0
TLS2_k127_4134472_3 Magnesium transport protein CorA K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 355.0
TLS2_k127_4134472_4 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006015 271.0
TLS2_k127_4134472_5 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000603 227.0
TLS2_k127_4134472_6 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000000000000000000000000000000000000000000000000001374 207.0
TLS2_k127_4134472_7 esterase lipase - - - 0.00000000000000000000000000000000000000000000000000007166 201.0
TLS2_k127_4134472_8 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000004527 156.0
TLS2_k127_4134472_9 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP - - - 0.0000000000000000000000000000000000001576 147.0
TLS2_k127_4138092_0 Cytochrome b/b6/petB K03891 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003191 422.0
TLS2_k127_4138092_1 Cytochrome b(C-terminal)/b6/petD - - - 0.00000000000000000000000000000000000000000000000000000000002167 218.0
TLS2_k127_4138092_2 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000006096 158.0
TLS2_k127_4138092_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000003485 144.0
TLS2_k127_4138092_4 oxidoreductase activity, acting on diphenols and related substances as donors K02636,K03886 - 1.10.9.1 0.0000000000000000000000000000000464 144.0
TLS2_k127_4138092_5 Cytochrome C and Quinol oxidase polypeptide I K00404 - 1.9.3.1 0.00000000000000000000000007204 123.0
TLS2_k127_4178871_0 non-ribosomal peptide synthetase - - - 2.356e-215 719.0
TLS2_k127_4178871_1 SMART Glycosyl hydrolase, family 13, subfamily, catalytic domain K05343 - 3.2.1.1,5.4.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 520.0
TLS2_k127_4178871_10 Domain of unknown function (DUF305) - - - 0.000000000000000000000000000000000000000000000000000000000000004046 222.0
TLS2_k127_4178871_11 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000684 228.0
TLS2_k127_4178871_12 mandelate racemase muconate lactonizing K01781 - 5.1.2.2 0.0000000000000000000000000000000000000000000000000000000000007051 230.0
TLS2_k127_4178871_13 PFAM Creatininase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000004337 205.0
TLS2_k127_4178871_14 Bacterial low temperature requirement A protein (LtrA) - - - 0.00000000000000000000000000000000000000000000000000008655 202.0
TLS2_k127_4178871_15 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000003792 179.0
TLS2_k127_4178871_16 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01856,K19802 - 5.1.1.20,5.5.1.1 0.000000000000000000000000000000000000000000003038 177.0
TLS2_k127_4178871_17 HNH nucleases - - - 0.00000000000000000000000000000000000000000001643 168.0
TLS2_k127_4178871_18 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000003453 139.0
TLS2_k127_4178871_19 superoxide dismutase activity K02674,K04565 - 1.15.1.1 0.00000000000000000000001384 112.0
TLS2_k127_4178871_2 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000652 396.0
TLS2_k127_4178871_20 Mannose-6-phosphate isomerase - - - 0.00000000000000000000007541 105.0
TLS2_k127_4178871_3 D-isomer specific 2-hydroxyacid dehydrogenase K00018 - 1.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004931 358.0
TLS2_k127_4178871_4 ABC-type multidrug transport system ATPase and permease K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 357.0
TLS2_k127_4178871_5 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 317.0
TLS2_k127_4178871_6 Malate/L-lactate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 300.0
TLS2_k127_4178871_7 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007973 272.0
TLS2_k127_4178871_8 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000309 260.0
TLS2_k127_4178871_9 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000004296 244.0
TLS2_k127_4204805_0 O-acetylhomoserine sulfhydrylase K01740 - 2.5.1.49 6.374e-225 704.0
TLS2_k127_4204805_1 alpha amylase, catalytic K01187 - 3.2.1.20 6.143e-205 653.0
TLS2_k127_4204805_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000001135 146.0
TLS2_k127_4204805_11 Unextendable partial coding region - - - 0.0000000000000002161 78.0
TLS2_k127_4204805_12 Glyoxalase-like domain K01759 - 4.4.1.5 0.0000000001108 69.0
TLS2_k127_4204805_13 PFAM Pentapeptide repeats (8 copies) - - - 0.000000000262 71.0
TLS2_k127_4204805_15 Cupin 2, conserved barrel domain protein - - - 0.000002613 56.0
TLS2_k127_4204805_16 Unextendable partial coding region - - - 0.000008338 49.0
TLS2_k127_4204805_17 - - - - 0.0001684 50.0
TLS2_k127_4204805_2 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 310.0
TLS2_k127_4204805_3 Polysaccharide pyruvyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004619 287.0
TLS2_k127_4204805_4 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000009836 269.0
TLS2_k127_4204805_5 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000002655 229.0
TLS2_k127_4204805_6 Thioredoxin K00384,K03671,K03672 - 1.8.1.8,1.8.1.9 0.00000000000000000000000000000000000000000000001021 174.0
TLS2_k127_4204805_7 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.0000000000000000000000000000000000000000000002833 176.0
TLS2_k127_4204805_8 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000002029 184.0
TLS2_k127_4204805_9 YbaK prolyl-tRNA synthetase associated region - - - 0.0000000000000000000000000000000000000000000832 164.0
TLS2_k127_4227997_0 Thiamine pyrophosphate enzyme, central domain K03336 - 3.7.1.22 1.589e-234 743.0
TLS2_k127_4227997_1 PFAM Alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 387.0
TLS2_k127_4227997_10 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000162 214.0
TLS2_k127_4227997_11 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000000000002652 199.0
TLS2_k127_4227997_12 Haem-degrading - - - 0.00000000000000000000000000000000000000000000000000001429 192.0
TLS2_k127_4227997_13 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000009918 202.0
TLS2_k127_4227997_14 PFAM amidohydrolase 2 - - - 0.00000000000000000000000000000000000000000000000002627 193.0
TLS2_k127_4227997_15 KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.0000000000000000000000000000007361 136.0
TLS2_k127_4227997_16 PFAM transposase IS204 IS1001 IS1096 IS1165 family protein K07485 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000001217 83.0
TLS2_k127_4227997_17 Cupin 2, conserved barrel domain protein - - - 0.000000000003826 78.0
TLS2_k127_4227997_18 Helix-turn-helix - - - 0.0001109 47.0
TLS2_k127_4227997_2 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 380.0
TLS2_k127_4227997_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 377.0
TLS2_k127_4227997_4 PFAM Short-chain dehydrogenase reductase SDR K00065 - 1.1.1.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 327.0
TLS2_k127_4227997_5 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001014 254.0
TLS2_k127_4227997_6 PFAM PfkB domain protein K00874 - 2.7.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000001377 256.0
TLS2_k127_4227997_7 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003865 248.0
TLS2_k127_4227997_8 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000003567 232.0
TLS2_k127_4227997_9 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000003914 224.0
TLS2_k127_4248009_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006822 400.0
TLS2_k127_4248009_1 Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) K00010 - 1.1.1.18,1.1.1.369 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 332.0
TLS2_k127_4248009_2 dehydratase K03335 - 4.2.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000002405 273.0
TLS2_k127_4343575_0 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 1.232e-291 914.0
TLS2_k127_4343575_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 2.305e-289 902.0
TLS2_k127_4343575_10 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000041 230.0
TLS2_k127_4343575_11 involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb - GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000003202 207.0
TLS2_k127_4343575_12 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000000000000000000000000001743 199.0
TLS2_k127_4343575_13 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 6.3.4.19 0.0000000000000000000000000000000007771 140.0
TLS2_k127_4343575_14 Metal-sensitive transcriptional repressor K21600 - - 0.000000000000000000000000000001777 122.0
TLS2_k127_4343575_16 Putative zinc-finger - - - 0.000000007952 59.0
TLS2_k127_4343575_17 Domain of unknown function (DUF4118) - - - 0.0000004928 59.0
TLS2_k127_4343575_18 Belongs to the WXG100 family - - - 0.00001139 54.0
TLS2_k127_4343575_2 His Kinase A (phosphoacceptor) domain - - - 2.957e-232 746.0
TLS2_k127_4343575_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 1.985e-213 679.0
TLS2_k127_4343575_4 DNA segregation ATPase FtsK SpoIIIE and related K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 503.0
TLS2_k127_4343575_5 Member of the two-component regulatory system kdpD kdpE involved in the regulation of the kdp operon K02483,K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 314.0
TLS2_k127_4343575_6 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000852 254.0
TLS2_k127_4343575_7 Sigma-70 region 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000189 260.0
TLS2_k127_4343575_8 Pfam:Zinicin_2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000003472 244.0
TLS2_k127_4343575_9 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000001844 237.0
TLS2_k127_4441803_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 4.504e-223 720.0
TLS2_k127_4441803_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 484.0
TLS2_k127_4441803_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 463.0
TLS2_k127_4441803_3 Ribosomal protein S1 K02945 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000725 477.0
TLS2_k127_4441803_4 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000006628 228.0
TLS2_k127_4441803_5 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 4.2.1.20 0.000000000000000000000000000000000000000000000000000000001404 223.0
TLS2_k127_4441803_6 Glycine cleavage T-protein C-terminal barrel domain K06980 - - 0.00000000000000000000000000000001125 139.0
TLS2_k127_4441803_7 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000002111 127.0
TLS2_k127_4441803_8 Flp pilus assembly protein CpaB K02279 - - 0.00000000009221 72.0
TLS2_k127_4486104_0 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002616 338.0
TLS2_k127_4486104_1 Polysaccharide pyruvyl transferase K16710 - - 0.000000000000000000000000000000000000000000000000000000000000000000003383 261.0
TLS2_k127_4486104_2 lysyltransferase activity K07027,K20468 - - 0.000000000000000000000000000000000000004499 166.0
TLS2_k127_4486104_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00441 - 1.12.98.1 0.00000000000000000000000002676 124.0
TLS2_k127_4495013_0 Quinone oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000584 370.0
TLS2_k127_4495013_1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 368.0
TLS2_k127_4495013_10 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00042 - 1.1.1.60 0.000000000000000000000000000000000000000000000000000000009547 210.0
TLS2_k127_4495013_11 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000003337 202.0
TLS2_k127_4495013_12 Glycine reductase complex selenoprotein A K10670 - 1.21.4.2,1.21.4.3,1.21.4.4 0.0000000000000000000000000004458 116.0
TLS2_k127_4495013_13 Thioredoxin - - - 0.000000000000000000000002148 106.0
TLS2_k127_4495013_14 Glycine reductase complex selenoprotein A K10670 - 1.21.4.2,1.21.4.3,1.21.4.4 0.00009892 51.0
TLS2_k127_4495013_2 Mycolic acid cyclopropane synthetase K00574,K20238 - 2.1.1.317,2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008869 322.0
TLS2_k127_4495013_3 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 323.0
TLS2_k127_4495013_4 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003132 285.0
TLS2_k127_4495013_5 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002557 288.0
TLS2_k127_4495013_6 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001742 285.0
TLS2_k127_4495013_7 [2Fe-2S] binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009552 251.0
TLS2_k127_4495013_8 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001414 274.0
TLS2_k127_4495013_9 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000007244 249.0
TLS2_k127_4693137_0 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K03520 - 1.2.5.3 0.0 1195.0
TLS2_k127_4693137_1 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008305 386.0
TLS2_k127_4693137_10 Domain of unknown function (DUF1905) - - - 0.000000000000000000000000000000003102 141.0
TLS2_k127_4693137_11 XdhC and CoxI family - - - 0.00000000000000000000000000002065 120.0
TLS2_k127_4693137_12 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000417 65.0
TLS2_k127_4693137_2 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 355.0
TLS2_k127_4693137_3 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006682 288.0
TLS2_k127_4693137_4 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003388 290.0
TLS2_k127_4693137_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000001221 266.0
TLS2_k127_4693137_6 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002772 258.0
TLS2_k127_4693137_7 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000003331 256.0
TLS2_k127_4693137_8 [2Fe-2S] binding domain K03518,K13483 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000001051 228.0
TLS2_k127_4693137_9 XdhC and CoxI family K07402 - - 0.0000000000000000000000000000000000000000000000000004344 194.0
TLS2_k127_4699648_0 Protein of unknown function, DUF255 K06888 - - 8.38e-196 634.0
TLS2_k127_4699648_1 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009745 501.0
TLS2_k127_4699648_10 Alcohol dehydrogenase GroES-like domain K00847 - 2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008165 338.0
TLS2_k127_4699648_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008734 317.0
TLS2_k127_4699648_12 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001874 293.0
TLS2_k127_4699648_13 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005449 284.0
TLS2_k127_4699648_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000008903 234.0
TLS2_k127_4699648_15 cytochrome oxidase assembly K02259 - - 0.000000000000000000000000000000000000000000000000001859 199.0
TLS2_k127_4699648_16 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000001824 164.0
TLS2_k127_4699648_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000004242 134.0
TLS2_k127_4699648_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000003573 118.0
TLS2_k127_4699648_19 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000005509 115.0
TLS2_k127_4699648_2 ThiF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 493.0
TLS2_k127_4699648_20 Mov34 MPN PAD-1 family K21140 - 3.13.1.6 0.000000000000000003842 98.0
TLS2_k127_4699648_21 Polymer-forming cytoskeletal - - - 0.000000000005489 78.0
TLS2_k127_4699648_3 NADH-quinone oxidoreductase chain L K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006068 506.0
TLS2_k127_4699648_4 Glycosyltransferase family 20 K00697,K16055 GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 501.0
TLS2_k127_4699648_5 Pyridoxal-phosphate dependent enzyme K01697 - 4.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009197 413.0
TLS2_k127_4699648_6 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 388.0
TLS2_k127_4699648_7 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 374.0
TLS2_k127_4699648_8 ATPases associated with a variety of cellular activities K01995,K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 352.0
TLS2_k127_4699648_9 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 348.0
TLS2_k127_4792573_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.147e-270 849.0
TLS2_k127_4792573_1 Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA K01638 - 2.3.3.9 8.191e-267 841.0
TLS2_k127_4792573_10 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 411.0
TLS2_k127_4792573_11 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008057 369.0
TLS2_k127_4792573_12 protein import - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007965 368.0
TLS2_k127_4792573_13 proline dipeptidase activity K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 369.0
TLS2_k127_4792573_14 Belongs to the HAD-like hydrolase superfamily K02566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 321.0
TLS2_k127_4792573_15 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006131 317.0
TLS2_k127_4792573_16 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 316.0
TLS2_k127_4792573_17 Aminotransferase, class I K14155 - 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 316.0
TLS2_k127_4792573_18 Drug resistance transporter Bcr CflA subfamily K03446,K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003473 288.0
TLS2_k127_4792573_19 Transcriptional regulator K02624 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004075 275.0
TLS2_k127_4792573_2 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955,K00956 GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234 2.7.1.25,2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006702 613.0
TLS2_k127_4792573_20 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004796 258.0
TLS2_k127_4792573_21 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000000000005191 269.0
TLS2_k127_4792573_22 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000004613 247.0
TLS2_k127_4792573_23 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001346 243.0
TLS2_k127_4792573_24 proline dipeptidase activity K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000002945 245.0
TLS2_k127_4792573_25 Catalyzes the synthesis of activated sulfate K00955,K00956 GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234 2.7.1.25,2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000442 236.0
TLS2_k127_4792573_26 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000001576 252.0
TLS2_k127_4792573_27 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000007452 242.0
TLS2_k127_4792573_28 PFAM Activator of Hsp90 ATPase 1 family protein - - - 0.000000000000000000000000000000000000000000000000000000001374 206.0
TLS2_k127_4792573_29 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000006343 201.0
TLS2_k127_4792573_3 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 546.0
TLS2_k127_4792573_30 - - - - 0.0000000000000000000000000000000000000000000000000001777 198.0
TLS2_k127_4792573_31 2-hydroxychromene-2-carboxylate isomerase - - - 0.000000000000000000000000000000000000000000000000004169 188.0
TLS2_k127_4792573_32 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000006378 186.0
TLS2_k127_4792573_33 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000008948 177.0
TLS2_k127_4792573_34 oxidoreductase - - - 0.00000000000000000000000000000000000000000001154 178.0
TLS2_k127_4792573_35 PFAM Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000001265 186.0
TLS2_k127_4792573_36 PFAM Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000001105 170.0
TLS2_k127_4792573_37 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000002812 162.0
TLS2_k127_4792573_38 PFAM SpoU rRNA Methylase family - - - 0.00000000000000000000000000000000000000000427 160.0
TLS2_k127_4792573_39 N-acetylmuramoyl-L-alanine amidase - - - 0.00000000000000000000000000000000000000001745 169.0
TLS2_k127_4792573_4 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 542.0
TLS2_k127_4792573_40 WHG domain - - - 0.0000000000000000000000000000000000000001437 166.0
TLS2_k127_4792573_41 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000003137 152.0
TLS2_k127_4792573_42 Sulfite exporter TauE/SafE - - - 0.00000000000000000000000000000005509 135.0
TLS2_k127_4792573_43 - - - - 0.0000000000000000000000000000202 130.0
TLS2_k127_4792573_44 Sodium/calcium exchanger protein K07301 - - 0.00000000000000000000000009372 115.0
TLS2_k127_4792573_45 Tetratricopeptide repeat - - - 0.000000000000000000000003525 113.0
TLS2_k127_4792573_46 Alpha/beta hydrolase family - - - 0.00000000000000000000001221 113.0
TLS2_k127_4792573_47 - - - - 0.00000000000000000001301 96.0
TLS2_k127_4792573_48 Dioxygenase K00449 - 1.13.11.3 0.00000000000000000008768 100.0
TLS2_k127_4792573_49 SpoU rRNA Methylase family - - - 0.0000000000000001617 94.0
TLS2_k127_4792573_5 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 566.0
TLS2_k127_4792573_50 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000005695 84.0
TLS2_k127_4792573_51 Sodium/calcium exchanger protein K07301 - - 0.00000000001978 67.0
TLS2_k127_4792573_52 phage tail tape measure protein - - - 0.00000000002712 76.0
TLS2_k127_4792573_53 positive regulation of macromolecule biosynthetic process - - - 0.00000000008804 64.0
TLS2_k127_4792573_54 rRNA binding K00334 - 1.6.5.3 0.00000001155 67.0
TLS2_k127_4792573_55 peptidyl-tyrosine sulfation - - - 0.0000003765 61.0
TLS2_k127_4792573_56 COG0835 Chemotaxis signal transduction protein K13489 - - 0.0000005689 59.0
TLS2_k127_4792573_57 Toxic component of a toxin-antitoxin (TA) module. An RNase K19686 - - 0.00002349 56.0
TLS2_k127_4792573_59 - - - - 0.0003295 51.0
TLS2_k127_4792573_6 FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 447.0
TLS2_k127_4792573_7 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 413.0
TLS2_k127_4792573_8 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009941 404.0
TLS2_k127_4792573_9 antibiotic catabolic process K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007408 397.0
TLS2_k127_4827928_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 1.546e-310 973.0
TLS2_k127_4827928_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 601.0
TLS2_k127_4827928_10 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 365.0
TLS2_k127_4827928_11 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 354.0
TLS2_k127_4827928_12 PFAM cation transporter K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007991 357.0
TLS2_k127_4827928_13 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000073 336.0
TLS2_k127_4827928_14 Sulfate transporter K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009998 361.0
TLS2_k127_4827928_15 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 350.0
TLS2_k127_4827928_16 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 325.0
TLS2_k127_4827928_17 Alanine dehydrogenase/PNT, C-terminal domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 301.0
TLS2_k127_4827928_18 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 308.0
TLS2_k127_4827928_19 Amino acid amide ABC transporter, ATP-binding protein, 1, HAAT family K01995,K11957 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008146 284.0
TLS2_k127_4827928_2 PFAM Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 587.0
TLS2_k127_4827928_20 Mur ligase middle domain K11754 GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002423 308.0
TLS2_k127_4827928_21 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002067 287.0
TLS2_k127_4827928_22 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008162 277.0
TLS2_k127_4827928_23 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002542 276.0
TLS2_k127_4827928_24 branched-chain amino acid transmembrane transporter activity K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001227 265.0
TLS2_k127_4827928_25 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000001844 262.0
TLS2_k127_4827928_26 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005627 272.0
TLS2_k127_4827928_27 Histidine kinase-like ATPases K01768,K02488,K17763 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65,4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001865 274.0
TLS2_k127_4827928_28 PFAM Thymidine kinase K00857 - 2.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000003087 231.0
TLS2_k127_4827928_29 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000865 238.0
TLS2_k127_4827928_3 glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 488.0
TLS2_k127_4827928_30 Metal-dependent hydrolases of the beta-lactamase superfamily III - - - 0.00000000000000000000000000000000000000000000000001724 188.0
TLS2_k127_4827928_31 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000007448 187.0
TLS2_k127_4827928_32 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000004776 171.0
TLS2_k127_4827928_33 oxidation-reduction process K09022 - 3.5.99.10 0.0000000000000000000000000000000000000001098 154.0
TLS2_k127_4827928_34 TrkA-N domain K03499 - - 0.00000000000000000000000000000000000009367 150.0
TLS2_k127_4827928_35 Sporulation and spore germination - - - 0.0000000000000000000000000000000005407 153.0
TLS2_k127_4827928_36 PFAM TrkA-N domain protein K03499 - - 0.0000000000000000000000000000000006401 146.0
TLS2_k127_4827928_37 ribosomal protein - - - 0.00000000000000000000000000008736 120.0
TLS2_k127_4827928_38 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000001005 116.0
TLS2_k127_4827928_39 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000002639 119.0
TLS2_k127_4827928_4 VWA domain containing CoxE-like protein K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 481.0
TLS2_k127_4827928_40 SdrD B-like domain - - - 0.000000000000000000000007388 113.0
TLS2_k127_4827928_41 cheY-homologous receiver domain - - - 0.00000000000000000000003328 103.0
TLS2_k127_4827928_42 Histidine kinase - - - 0.0000000000000000000006986 110.0
TLS2_k127_4827928_43 Protein of unknown function (DUF983) - - - 0.000000000000000002631 94.0
TLS2_k127_4827928_44 Endoribonuclease L-PSP - - - 0.00000000000001057 82.0
TLS2_k127_4827928_45 S-layer homology domain - - - 0.0000000000003034 84.0
TLS2_k127_4827928_46 Involved in formation and maintenance of cell shape K03570 - - 0.00000000003068 74.0
TLS2_k127_4827928_48 Integrase core domain - - - 0.000004586 58.0
TLS2_k127_4827928_5 Cell shape determining protein MreB Mrl K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000391 470.0
TLS2_k127_4827928_50 - - - - 0.00002078 59.0
TLS2_k127_4827928_51 OsmC-like protein - - - 0.00006551 49.0
TLS2_k127_4827928_52 redox protein regulator of disulfide bond formation - - - 0.000108 48.0
TLS2_k127_4827928_53 rod shape-determining protein (MreD) K03571 - - 0.0001725 52.0
TLS2_k127_4827928_54 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.0002001 48.0
TLS2_k127_4827928_55 - - - - 0.0005731 50.0
TLS2_k127_4827928_6 Ribonuclease E/G family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 474.0
TLS2_k127_4827928_7 Cation transport protein K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005173 409.0
TLS2_k127_4827928_8 PFAM ATPase associated with various cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 362.0
TLS2_k127_4827928_9 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 371.0
TLS2_k127_4900325_0 ADP binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002906 502.0
TLS2_k127_4900325_1 SpoIID LytB domain protein - - - 0.00000000000000000000000000000000000000000000003505 191.0
TLS2_k127_4900325_2 oxidoreductase - - - 0.00000000000000000000000000000000000000000005208 184.0
TLS2_k127_4900325_3 Belongs to the peptidase S8 family - - - 0.0000000000009352 81.0
TLS2_k127_4906053_0 Major facilitator superfamily K08225 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006892 316.0
TLS2_k127_4906053_1 - - - - 0.0000000000000002073 88.0
TLS2_k127_4906053_2 AAA domain - - - 0.000000003272 62.0
TLS2_k127_4906053_3 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.0003276 44.0
TLS2_k127_4973567_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006088 472.0
TLS2_k127_4973567_1 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 447.0
TLS2_k127_4973567_10 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000104 134.0
TLS2_k127_4973567_11 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000003419 99.0
TLS2_k127_4973567_12 - - - - 0.0000000000000000000622 103.0
TLS2_k127_4973567_13 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000001719 100.0
TLS2_k127_4973567_14 - - - - 0.00000000007646 70.0
TLS2_k127_4973567_16 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.00009437 51.0
TLS2_k127_4973567_2 Phospholipase D. Active site motifs. K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 387.0
TLS2_k127_4973567_3 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 340.0
TLS2_k127_4973567_4 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005081 274.0
TLS2_k127_4973567_5 KR domain K00065 - 1.1.1.127 0.0000000000000000000000000000000000000000000000000000000000000000000000347 248.0
TLS2_k127_4973567_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03090 GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000002797 213.0
TLS2_k127_4973567_7 Single-strand binding protein family K03111 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000001919 160.0
TLS2_k127_4973567_8 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000005245 162.0
TLS2_k127_4973567_9 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000009904 136.0
TLS2_k127_5000650_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K15408 - 1.9.3.1 0.0 1144.0
TLS2_k127_5000650_1 ATP-dependent helicase HrpB K03579 - 3.6.4.13 2.941e-250 796.0
TLS2_k127_5000650_10 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 336.0
TLS2_k127_5000650_11 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 308.0
TLS2_k127_5000650_12 PFAM Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 317.0
TLS2_k127_5000650_13 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009237 299.0
TLS2_k127_5000650_14 transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001964 284.0
TLS2_k127_5000650_15 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001213 276.0
TLS2_k127_5000650_16 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005079 278.0
TLS2_k127_5000650_17 Domain of unknown function (DUF368) K08974 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001376 273.0
TLS2_k127_5000650_18 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001399 259.0
TLS2_k127_5000650_19 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.00000000000000000000000000000000000000000000000000000000000000000002548 248.0
TLS2_k127_5000650_2 Glycosyl hydrolase family 65 central catalytic domain K05342 - 2.4.1.64 2.172e-226 733.0
TLS2_k127_5000650_20 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000001557 241.0
TLS2_k127_5000650_21 Aspartyl asparaginyl beta-hydroxylase K12979 - - 0.000000000000000000000000000000000000000000000000000000000000000001044 241.0
TLS2_k127_5000650_22 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000004196 233.0
TLS2_k127_5000650_23 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000005334 230.0
TLS2_k127_5000650_24 Peptidase s1 and s6 chymotrypsin hap - - - 0.00000000000000000000000000000000000000000000000000000000009902 220.0
TLS2_k127_5000650_25 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000002021 221.0
TLS2_k127_5000650_26 Predicted membrane protein (DUF2243) - - - 0.00000000000000000000000000000000000000000000000000001463 194.0
TLS2_k127_5000650_27 pyridoxamine 5-phosphate - - - 0.000000000000000000000000000000000000000000000002962 182.0
TLS2_k127_5000650_28 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000001137 192.0
TLS2_k127_5000650_29 Response regulator receiver - - - 0.000000000000000000000000000000000000000000002422 179.0
TLS2_k127_5000650_3 IMP dehydrogenase GMP reductase K00088 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.1.1.205 3.374e-201 636.0
TLS2_k127_5000650_30 membrane - - - 0.000000000000000000000000000000000000000006227 160.0
TLS2_k127_5000650_31 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000001448 154.0
TLS2_k127_5000650_32 CBS domain - GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0009628,GO:0016020,GO:0030312,GO:0035821,GO:0036293,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0070482,GO:0071944,GO:0075136 - 0.000000000000000000000000000000000008032 141.0
TLS2_k127_5000650_33 - - - - 0.000000000000000000000000000000007735 140.0
TLS2_k127_5000650_34 Rho termination factor, N-terminal domain - - - 0.0000000000000000000000000000005432 127.0
TLS2_k127_5000650_35 His Kinase A (phosphoacceptor) domain K07654 - 2.7.13.3 0.000000000000000000000000000008974 136.0
TLS2_k127_5000650_36 - - - - 0.00000000000000000000000000001187 120.0
TLS2_k127_5000650_37 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000003686 119.0
TLS2_k127_5000650_38 protein phosphatase 2C domain protein - GO:0000287,GO:0003674,GO:0003824,GO:0004035,GO:0005488,GO:0005515,GO:0006355,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019219,GO:0019222,GO:0030145,GO:0031323,GO:0031326,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000001395 126.0
TLS2_k127_5000650_39 Competence-damaged protein - - - 0.0000000000000000000000002551 113.0
TLS2_k127_5000650_4 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 534.0
TLS2_k127_5000650_40 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K02548,K03179,K17105 - 2.5.1.39,2.5.1.42,2.5.1.74 0.0000000000000000000000008866 120.0
TLS2_k127_5000650_41 Metallo-peptidase family M12 - - - 0.00000000000000000000004539 110.0
TLS2_k127_5000650_42 - - - - 0.00000000000000006384 83.0
TLS2_k127_5000650_43 YrhK-like protein - - - 0.0000000000000003571 81.0
TLS2_k127_5000650_44 PFAM peptidase M15B and M15C DD-carboxypeptidase VanY endolysin - - - 0.0000000000000005027 92.0
TLS2_k127_5000650_45 Major facilitator superfamily - - - 0.0000000000000005346 91.0
TLS2_k127_5000650_46 Major facilitator superfamily - - - 0.000000000000004669 87.0
TLS2_k127_5000650_47 Cysteine-rich secretory protein family - - - 0.0000000000000168 84.0
TLS2_k127_5000650_48 Sulfite exporter TauE/SafE - - - 0.0000000000001574 80.0
TLS2_k127_5000650_5 PFAM Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000098 481.0
TLS2_k127_5000650_6 Pyridoxal-dependent decarboxylase conserved domain K01593,K01634 - 4.1.1.105,4.1.1.28,4.1.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007266 488.0
TLS2_k127_5000650_7 Aldehyde dehydrogenase family K00128,K22445 - 1.2.1.3,1.2.99.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008667 479.0
TLS2_k127_5000650_8 Fumarylacetoacetase K01555 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 393.0
TLS2_k127_5000650_9 aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 389.0
TLS2_k127_5188968_0 PFAM sodium hydrogen exchanger - - - 1.404e-200 646.0
TLS2_k127_5188968_1 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008734 469.0
TLS2_k127_5188968_10 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000002462 156.0
TLS2_k127_5188968_11 - - - - 0.0000000000000000000000000000000000000003633 164.0
TLS2_k127_5188968_12 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000000000000000002763 95.0
TLS2_k127_5188968_13 Nucleotidyltransferase domain - - - 0.000000000000000003197 93.0
TLS2_k127_5188968_14 HEPN domain - - - 0.00000000000007962 77.0
TLS2_k127_5188968_15 Phage integrase family - - - 0.000000006103 63.0
TLS2_k127_5188968_16 membrane K07149 - - 0.00000001559 65.0
TLS2_k127_5188968_17 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000001104 61.0
TLS2_k127_5188968_19 - - - - 0.00001096 50.0
TLS2_k127_5188968_2 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) K05947 - 2.4.1.217 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007724 377.0
TLS2_k127_5188968_20 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.00001857 51.0
TLS2_k127_5188968_21 Protein of unknown function (DUF1634) - - - 0.000179 51.0
TLS2_k127_5188968_3 involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009397 358.0
TLS2_k127_5188968_4 pfam mofrl K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 327.0
TLS2_k127_5188968_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000001131 231.0
TLS2_k127_5188968_6 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000003633 222.0
TLS2_k127_5188968_7 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000001013 223.0
TLS2_k127_5188968_9 UTRA K03710 - - 0.00000000000000000000000000000000000000000001481 171.0
TLS2_k127_5205628_0 FAD linked oxidase - - - 8.043e-306 954.0
TLS2_k127_5205628_1 Isocitrate lyase K01637 - 4.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 606.0
TLS2_k127_5205628_10 FR47-like protein - - - 0.0000000000000000000000000000000000000000002447 174.0
TLS2_k127_5205628_11 Belongs to the pirin family K06911 - - 0.000000000000000000001167 95.0
TLS2_k127_5205628_2 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 591.0
TLS2_k127_5205628_3 Ftsk_gamma K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008531 572.0
TLS2_k127_5205628_4 IrrE N-terminal-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 423.0
TLS2_k127_5205628_5 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009054 408.0
TLS2_k127_5205628_6 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005904 390.0
TLS2_k127_5205628_7 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 329.0
TLS2_k127_5205628_8 Histidinol phosphate phosphatase, HisJ K04486 - 3.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008961 316.0
TLS2_k127_5205628_9 e3 binding domain K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003614 290.0
TLS2_k127_5249021_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 448.0
TLS2_k127_5249021_1 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate - - - 0.0000000000000000000000000000000001344 150.0
TLS2_k127_5249021_2 Type IV leader peptidase family K02654 - 3.4.23.43 0.000000000000000000000000001944 121.0
TLS2_k127_5249021_3 Domain of unknown function (DUF4388) - - - 0.000000000482 72.0
TLS2_k127_52650_0 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 508.0
TLS2_k127_52650_1 helix_turn_helix, Lux Regulon K03556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 512.0
TLS2_k127_52650_10 Membrane - - - 0.0000000000000000000000000000000003958 143.0
TLS2_k127_52650_11 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000007578 132.0
TLS2_k127_52650_12 YCII-related domain - - - 0.00000000000000000000000000000001087 130.0
TLS2_k127_52650_13 Regulatory protein MarR - - - 0.0000000000000000000000000002428 121.0
TLS2_k127_52650_15 SnoaL-like domain - - - 0.0000000000000000000000001687 122.0
TLS2_k127_52650_16 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.0000000000000000003423 92.0
TLS2_k127_52650_17 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.0000000000000000006293 96.0
TLS2_k127_52650_18 - - - - 0.000001799 55.0
TLS2_k127_52650_2 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 422.0
TLS2_k127_52650_3 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 402.0
TLS2_k127_52650_4 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005103 243.0
TLS2_k127_52650_5 Protein of unknown function (DUF1298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000003848 264.0
TLS2_k127_52650_6 Carbon-nitrogen hydrolase K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000001144 256.0
TLS2_k127_52650_7 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000002955 229.0
TLS2_k127_52650_8 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000000001793 140.0
TLS2_k127_52650_9 CAAX protease self-immunity - - - 0.000000000000000000000000000000000004245 151.0
TLS2_k127_5346520_0 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000009491 240.0
TLS2_k127_5346520_1 Cell division protein FtsQ K03589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - 0.00000000179 70.0
TLS2_k127_542155_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1200.0
TLS2_k127_542155_1 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 518.0
TLS2_k127_542155_10 Aldose 1-epimerase K01785 - 5.1.3.3 0.00000000000000000000000000000000000000000000000008199 187.0
TLS2_k127_542155_11 Sortase family K07284 - 3.4.22.70 0.0000000000000000000000000000000000000897 151.0
TLS2_k127_542155_12 HD domain - - - 0.0000000000000000000000000000000007245 147.0
TLS2_k127_542155_13 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000002622 142.0
TLS2_k127_542155_14 transcriptional regulator - - - 0.00000000000000000000000000003689 126.0
TLS2_k127_542155_15 - - - - 0.000000000000000000000000001125 121.0
TLS2_k127_542155_16 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.00000000000000000000000001761 116.0
TLS2_k127_542155_17 - - - - 0.00000000000000002748 88.0
TLS2_k127_542155_18 Protein of unknown function (DUF2752) - - - 0.000000000008372 72.0
TLS2_k127_542155_19 Family of unknown function (DUF5317) - - - 0.00000000001188 72.0
TLS2_k127_542155_2 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 372.0
TLS2_k127_542155_20 - - - - 0.0000000001189 66.0
TLS2_k127_542155_21 Toxic component of a toxin-antitoxin (TA) module K07171 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.0000005104 60.0
TLS2_k127_542155_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003417 357.0
TLS2_k127_542155_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 332.0
TLS2_k127_542155_5 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005184 279.0
TLS2_k127_542155_6 Binding-protein-dependent transport system inner membrane component K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005654 271.0
TLS2_k127_542155_7 Bacterial extracellular solute-binding protein K11069 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003624 251.0
TLS2_k127_542155_8 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002739 237.0
TLS2_k127_542155_9 enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000001352 203.0
TLS2_k127_5442473_0 transferase activity, transferring glycosyl groups - - - 1.249e-197 644.0
TLS2_k127_5442473_1 pyridoxamine 5-phosphate - - - 0.00000000000000000000000000000000000000000000000000004696 192.0
TLS2_k127_5442473_2 LysE type translocator - - - 0.00000000000000000000000000000000000000000000001034 179.0
TLS2_k127_5442473_3 PIN domain - - - 0.00000000000000000000000000001114 124.0
TLS2_k127_5442473_4 positive regulation of growth - - - 0.0000000000000003247 80.0
TLS2_k127_5443508_0 Tricorn protease homolog K08676 - - 2.154e-319 1009.0
TLS2_k127_5443508_1 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030312,GO:0030976,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 3.936e-231 732.0
TLS2_k127_5443508_10 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008619 370.0
TLS2_k127_5443508_11 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 368.0
TLS2_k127_5443508_12 Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 364.0
TLS2_k127_5443508_13 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 371.0
TLS2_k127_5443508_14 associated with various cellular activities K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 372.0
TLS2_k127_5443508_15 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0008150,GO:0040007 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003217 329.0
TLS2_k127_5443508_16 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007506 318.0
TLS2_k127_5443508_17 Beta-eliminating lyase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000826 300.0
TLS2_k127_5443508_18 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008822 291.0
TLS2_k127_5443508_19 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000437 300.0
TLS2_k127_5443508_2 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 4.2.1.9 8.166e-230 726.0
TLS2_k127_5443508_20 PFAM short chain dehydrogenase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000001478 274.0
TLS2_k127_5443508_21 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000001084 271.0
TLS2_k127_5443508_22 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001999 276.0
TLS2_k127_5443508_23 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000002655 229.0
TLS2_k127_5443508_24 glucokinase K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000001861 214.0
TLS2_k127_5443508_25 PFAM HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000001017 191.0
TLS2_k127_5443508_26 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000001275 194.0
TLS2_k127_5443508_27 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000001519 181.0
TLS2_k127_5443508_28 PFAM transglutaminase domain protein - - - 0.000000000000000000000000000000000000000000000007515 198.0
TLS2_k127_5443508_29 Acetolactate synthase K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.00000000000000000000000000000000000000000000008237 173.0
TLS2_k127_5443508_3 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 7.633e-196 633.0
TLS2_k127_5443508_30 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000296 175.0
TLS2_k127_5443508_31 Evidence 2b Function of strongly homologous gene K07171 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.000000000000000000000000000000000000000001259 162.0
TLS2_k127_5443508_32 MazG-like family - - - 0.00000000000000000000000000000000000000003923 165.0
TLS2_k127_5443508_33 membrane - - - 0.00000000000000000000000000000000000000004272 161.0
TLS2_k127_5443508_34 - - - - 0.000000000000000000000000000000000000008139 152.0
TLS2_k127_5443508_35 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000001187 151.0
TLS2_k127_5443508_36 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000002256 121.0
TLS2_k127_5443508_37 peptidase inhibitor activity - - - 0.000000000000000000000000003025 123.0
TLS2_k127_5443508_38 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.000000000000000000000000003644 117.0
TLS2_k127_5443508_39 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000001483 108.0
TLS2_k127_5443508_4 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 512.0
TLS2_k127_5443508_40 Evidence 4 Homologs of previously reported genes of - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.000000000000000000000007932 107.0
TLS2_k127_5443508_41 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000001997 111.0
TLS2_k127_5443508_42 Phosphoglycerate mutase family - - - 0.000000000000000000184 104.0
TLS2_k127_5443508_43 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000002155 84.0
TLS2_k127_5443508_44 Protein of unknown function (DUF1232) - - - 0.0000000000000006306 91.0
TLS2_k127_5443508_45 - - - - 0.000000000006383 68.0
TLS2_k127_5443508_46 - - - - 0.000000143 62.0
TLS2_k127_5443508_47 Luciferase-like monooxygenase - - - 0.0000002698 61.0
TLS2_k127_5443508_48 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.0001011 54.0
TLS2_k127_5443508_49 Psort location CytoplasmicMembrane, score - - - 0.0008446 50.0
TLS2_k127_5443508_5 Aminotransferase class I and II K10206,K14261 GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 505.0
TLS2_k127_5443508_6 Isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007639 473.0
TLS2_k127_5443508_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007742 466.0
TLS2_k127_5443508_8 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 453.0
TLS2_k127_5443508_9 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000292 393.0
TLS2_k127_5468303_0 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.00000000000000000000000000000000000000000000000000000000000000003565 235.0
TLS2_k127_5468303_1 metal-dependent phosphohydrolase HD region - - - 0.00000000000000000004762 104.0
TLS2_k127_5651503_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 2.215e-233 743.0
TLS2_k127_5651503_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 413.0
TLS2_k127_5651503_10 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000007372 201.0
TLS2_k127_5651503_11 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000002985 203.0
TLS2_k127_5651503_12 Enoyl-CoA hydratase/isomerase K01661,K07536 - 4.1.3.36 0.0000000000000000000000000000000000000000000000000005894 194.0
TLS2_k127_5651503_13 homoserine transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000101 176.0
TLS2_k127_5651503_14 Bacterial transcription activator, effector binding domain - - - 0.0000000000000000000000000000000000000002452 158.0
TLS2_k127_5651503_15 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity - - - 0.0000000000000000000000002929 116.0
TLS2_k127_5651503_16 dehydratase K07068,K14449 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0015977,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019752,GO:0032787,GO:0043427,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0045733,GO:0046185,GO:0046395,GO:0046487,GO:0071704,GO:0072329,GO:1901575 4.2.1.148 0.00000000000002716 81.0
TLS2_k127_5651503_2 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 357.0
TLS2_k127_5651503_3 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 351.0
TLS2_k127_5651503_4 F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 340.0
TLS2_k127_5651503_5 acyl-CoA transferase carnitine dehydratase K18702 - 2.8.3.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 343.0
TLS2_k127_5651503_6 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 319.0
TLS2_k127_5651503_7 CoA binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006043 337.0
TLS2_k127_5651503_8 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001053 254.0
TLS2_k127_5651503_9 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000001627 222.0
TLS2_k127_5726253_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1080.0
TLS2_k127_5726253_1 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 7.957e-306 966.0
TLS2_k127_5726253_10 Belongs to the aldehyde dehydrogenase family K00128,K00130,K00135,K00138,K00146 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.39,1.2.1.79,1.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003958 506.0
TLS2_k127_5726253_11 Dehydrogenase E1 component K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 461.0
TLS2_k127_5726253_12 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007034 447.0
TLS2_k127_5726253_13 acetyltransferase component of pyruvate dehydrogenase complex K00627,K00658 - 2.3.1.12,2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 419.0
TLS2_k127_5726253_14 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 351.0
TLS2_k127_5726253_15 CBS domain containing protein K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006567 331.0
TLS2_k127_5726253_16 short-chain K00034,K00038,K00046 - 1.1.1.47,1.1.1.53,1.1.1.69 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 312.0
TLS2_k127_5726253_17 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 307.0
TLS2_k127_5726253_18 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 288.0
TLS2_k127_5726253_19 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000151 280.0
TLS2_k127_5726253_2 synthetase K01895 - 6.2.1.1 8.864e-226 732.0
TLS2_k127_5726253_20 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000006855 249.0
TLS2_k127_5726253_21 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000008145 241.0
TLS2_k127_5726253_22 Helix-turn-helix domain, rpiR family - - - 0.00000000000000000000000000000000000000000000000000000000000000319 230.0
TLS2_k127_5726253_23 Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000000000000000000000000003119 218.0
TLS2_k127_5726253_24 ABC-type Na efflux pump, permease K01992 - - 0.00000000000000000000000000000000000000000000000000004039 213.0
TLS2_k127_5726253_25 translation release factor activity - - - 0.0000000000000000000000000000000000000000000000000007486 204.0
TLS2_k127_5726253_26 Virulence factor BrkB - - - 0.0000000000000000000000000000000000000000000000000009223 196.0
TLS2_k127_5726253_27 TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000001905 183.0
TLS2_k127_5726253_28 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000001378 165.0
TLS2_k127_5726253_29 - - - - 0.000000000000000000000000000000000001571 149.0
TLS2_k127_5726253_3 Amino acid permease K16238 - - 4.01e-209 661.0
TLS2_k127_5726253_30 Multisubunit Na H antiporter MnhC subunit K05567 - - 0.00000000000000000000000000000000006952 139.0
TLS2_k127_5726253_31 - - - - 0.0000000000000000000000000000001748 129.0
TLS2_k127_5726253_32 Putative NAD(P)-binding K03499 - - 0.00000000000000000000000000000137 131.0
TLS2_k127_5726253_33 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K05565,K14086 - - 0.0000000000000000000000000004593 118.0
TLS2_k127_5726253_34 Na+/H+ antiporter subunit K05571 - - 0.00000000000000000000004003 106.0
TLS2_k127_5726253_35 COG1863 Multisubunit Na H antiporter, MnhE subunit K05569 - - 0.000000000000000001341 94.0
TLS2_k127_5726253_36 - - - - 0.00000000000000000203 100.0
TLS2_k127_5726253_37 serine-type aminopeptidase activity K02030,K14475 - - 0.000000000000003612 87.0
TLS2_k127_5726253_38 Histidine kinase - - - 0.0000000000001182 74.0
TLS2_k127_5726253_39 Phosphopantetheine attachment site - - - 0.0000000001683 74.0
TLS2_k127_5726253_4 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 1.357e-201 638.0
TLS2_k127_5726253_40 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.0000002669 61.0
TLS2_k127_5726253_41 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.0000008647 57.0
TLS2_k127_5726253_42 Belongs to the universal stress protein A family - - - 0.00003131 54.0
TLS2_k127_5726253_43 Two component transcriptional regulator, LuxR family K07695 - - 0.0007031 47.0
TLS2_k127_5726253_5 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 579.0
TLS2_k127_5726253_6 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit K05565,K14086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005175 586.0
TLS2_k127_5726253_7 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 518.0
TLS2_k127_5726253_8 Belongs to the RtcB family K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 516.0
TLS2_k127_5726253_9 Proton-conducting membrane transporter K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 521.0
TLS2_k127_573179_0 PFAM carbohydrate kinase K00854 - 2.7.1.17 3.581e-200 634.0
TLS2_k127_573179_1 Belongs to the xylose isomerase family K01805 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 589.0
TLS2_k127_573179_10 PFAM Peptidase family M20 M25 M40 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000012 263.0
TLS2_k127_573179_11 Endoribonuclease L-PSP - - - 0.00000000000000000001762 105.0
TLS2_k127_573179_12 - K22014 - - 0.000000000000001742 80.0
TLS2_k127_573179_2 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 595.0
TLS2_k127_573179_3 Belongs to the binding-protein-dependent transport system permease family K10544 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 531.0
TLS2_k127_573179_4 Xaa-Pro aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 510.0
TLS2_k127_573179_5 ABC transporter substrate-binding protein K10543 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009911 434.0
TLS2_k127_573179_6 ATPases associated with a variety of cellular activities K10545 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 342.0
TLS2_k127_573179_7 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003006 319.0
TLS2_k127_573179_8 PFAM ROK family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009474 302.0
TLS2_k127_573179_9 electron transport chain K00347,K03614,K21163 - 1.6.5.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008794 296.0
TLS2_k127_5903133_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1354.0
TLS2_k127_5903133_1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 2.669e-205 667.0
TLS2_k127_5903133_10 Sigma-70 region 2 - - - 0.00000000000000000000000000000000000006509 156.0
TLS2_k127_5903133_11 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K00332 - 1.6.5.3 0.00000000000000000000000000000001475 141.0
TLS2_k127_5903133_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.3 0.00000000000000000000000000009724 121.0
TLS2_k127_5903133_13 PFAM Response regulator receiver domain, Transcriptional regulatory protein, C terminal K07665 - - 0.000000000000000002107 91.0
TLS2_k127_5903133_14 Belongs to the universal stress protein A family - - - 0.0000000000002386 83.0
TLS2_k127_5903133_15 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000006123 72.0
TLS2_k127_5903133_16 - - - - 0.000000001482 61.0
TLS2_k127_5903133_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000573 542.0
TLS2_k127_5903133_3 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007089 465.0
TLS2_k127_5903133_4 membrane protein terC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 372.0
TLS2_k127_5903133_5 PFAM regulatory protein LuxR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 349.0
TLS2_k127_5903133_6 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003475 306.0
TLS2_k127_5903133_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001011 286.0
TLS2_k127_5903133_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000001597 244.0
TLS2_k127_5903133_9 NADH ubiquinone oxidoreductase 24 kD subunit K00334 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000000000000000000000002863 158.0
TLS2_k127_5972805_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1049.0
TLS2_k127_5972805_1 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 4.257e-238 808.0
TLS2_k127_5972805_10 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005083 506.0
TLS2_k127_5972805_11 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000423 478.0
TLS2_k127_5972805_12 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431 - 3.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 471.0
TLS2_k127_5972805_13 Von Willebrand factor, type A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 489.0
TLS2_k127_5972805_14 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 471.0
TLS2_k127_5972805_15 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000588 467.0
TLS2_k127_5972805_16 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 394.0
TLS2_k127_5972805_17 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006069 395.0
TLS2_k127_5972805_18 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 382.0
TLS2_k127_5972805_19 helix_turn_helix gluconate operon transcriptional repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007033 379.0
TLS2_k127_5972805_2 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 2.169e-223 702.0
TLS2_k127_5972805_20 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 362.0
TLS2_k127_5972805_21 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 338.0
TLS2_k127_5972805_22 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 322.0
TLS2_k127_5972805_23 ABC-type nitrate sulfonate bicarbonate transport system ATPase component K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004752 326.0
TLS2_k127_5972805_24 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008155 325.0
TLS2_k127_5972805_25 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005682 318.0
TLS2_k127_5972805_26 MazG family K02499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 311.0
TLS2_k127_5972805_27 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001587 308.0
TLS2_k127_5972805_28 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006144 295.0
TLS2_k127_5972805_29 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002836 276.0
TLS2_k127_5972805_3 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 5.292e-206 652.0
TLS2_k127_5972805_30 succinyl-diaminopimelate desuccinylase K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000004354 284.0
TLS2_k127_5972805_31 Cysteine desulfurase K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000002641 276.0
TLS2_k127_5972805_32 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002675 255.0
TLS2_k127_5972805_33 3-methyladenine DNA glycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001225 244.0
TLS2_k127_5972805_34 VanW like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000008762 255.0
TLS2_k127_5972805_35 2-hydroxyacid dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000001459 237.0
TLS2_k127_5972805_36 Belongs to the enoyl-CoA hydratase isomerase family K01692 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000009886 217.0
TLS2_k127_5972805_37 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000001034 219.0
TLS2_k127_5972805_38 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.00000000000000000000000000000000000000000000000000009812 197.0
TLS2_k127_5972805_39 membrane - - - 0.00000000000000000000000000000000000000000000000001208 191.0
TLS2_k127_5972805_4 Dihydropyrimidinase K01464 - 3.5.2.2 8.355e-206 651.0
TLS2_k127_5972805_40 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 GO:0008150,GO:0040007 5.4.99.18 0.000000000000000000000000000000000000000000000000285 182.0
TLS2_k127_5972805_41 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000008294 192.0
TLS2_k127_5972805_42 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 0.00000000000000000000000000000000000000000000003168 179.0
TLS2_k127_5972805_43 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000122 180.0
TLS2_k127_5972805_44 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000003657 171.0
TLS2_k127_5972805_45 Inositol monophosphatase family K01092,K05602 - 3.1.3.15,3.1.3.25 0.00000000000000000000000000000000000000000004271 175.0
TLS2_k127_5972805_46 Protein of unknown function (DUF418) - - - 0.0000000000000000000000000000000000000000003065 174.0
TLS2_k127_5972805_47 ABC transporter - - - 0.0000000000000000000000000000000000000000006401 178.0
TLS2_k127_5972805_48 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000003355 169.0
TLS2_k127_5972805_49 Hydrolase of the alpha beta-hydrolase K07020 - - 0.00000000000000000000000000000000002334 153.0
TLS2_k127_5972805_5 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 628.0
TLS2_k127_5972805_50 Uncharacterized conserved protein (DUF2267) - - - 0.000000000000000000000000000000001051 134.0
TLS2_k127_5972805_51 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000002955 137.0
TLS2_k127_5972805_52 AraC-like ligand binding domain - - - 0.00000000000000000000000000000005274 140.0
TLS2_k127_5972805_53 oxidoreductase activity, acting on CH-OH group of donors - - - 0.00000000000000000000000000003905 121.0
TLS2_k127_5972805_54 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.00000000000000000000000000005618 121.0
TLS2_k127_5972805_55 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000188 122.0
TLS2_k127_5972805_56 Cupin domain - - - 0.0000000000000000000000001817 108.0
TLS2_k127_5972805_57 thiolester hydrolase activity K17362 - - 0.0000000000000000000000004807 113.0
TLS2_k127_5972805_58 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000008079 107.0
TLS2_k127_5972805_59 Protein of unknown function (DUF501) K09009 - - 0.00000000000000000003625 103.0
TLS2_k127_5972805_6 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00140,K00823 - 1.2.1.18,1.2.1.27,2.6.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 598.0
TLS2_k127_5972805_60 rRNA binding K02890,K02899,K04074 - - 0.00000000000000000004442 102.0
TLS2_k127_5972805_61 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 0.000000000000004144 87.0
TLS2_k127_5972805_62 PFAM Diacylglycerol kinase catalytic - - - 0.000000000000008071 86.0
TLS2_k127_5972805_63 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000008136 77.0
TLS2_k127_5972805_65 Bacterial extracellular solute-binding protein - - - 0.000003791 59.0
TLS2_k127_5972805_66 - - - - 0.0000151 59.0
TLS2_k127_5972805_67 Septum formation initiator K13052 - - 0.00001913 54.0
TLS2_k127_5972805_7 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 535.0
TLS2_k127_5972805_8 [isocitrate dehydrogenase (NADP+)] phosphatase activity K00906 GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007885 535.0
TLS2_k127_5972805_9 Aminotransferase K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 524.0
TLS2_k127_597924_0 PFAM PfkB domain protein K03338 - 2.7.1.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 390.0
TLS2_k127_597924_1 deoxyribose-phosphate aldolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 330.0
TLS2_k127_597924_2 KduI/IolB family K03337 - 5.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005365 316.0
TLS2_k127_597924_4 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000006878 276.0
TLS2_k127_597924_5 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000002588 176.0
TLS2_k127_597924_6 ABC transporter, ATP-binding protein K02056 - 3.6.3.17 0.00000000000000000000000000000000386 130.0
TLS2_k127_597924_7 SnoaL-like domain - - - 0.000000000000000000000000000009934 127.0
TLS2_k127_597924_8 CHRD domain - - - 0.0000000000000000000002056 104.0
TLS2_k127_597924_9 - - - - 0.00000000000005232 84.0
TLS2_k127_5988027_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02827 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.10.3.12,1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 596.0
TLS2_k127_5988027_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003304 544.0
TLS2_k127_5988027_10 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000002164 262.0
TLS2_k127_5988027_11 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003978 259.0
TLS2_k127_5988027_12 branched-chain amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000006038 222.0
TLS2_k127_5988027_13 Glutamate-cysteine ligase family 2(GCS2) K06048 - - 0.000000000000000000000000000000000000000000000000000000005855 203.0
TLS2_k127_5988027_14 Cytochrome c oxidase subunit III K02276,K02299 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 0.000000000000000000000000000000000000000000000000000002848 197.0
TLS2_k127_5988027_15 XdhC and CoxI family K07402 - - 0.00000000000000000000000000000000000000000000000000004608 197.0
TLS2_k127_5988027_16 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02862 - - 0.000000000000000000000000000000000000000000000000008236 190.0
TLS2_k127_5988027_17 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000003101 180.0
TLS2_k127_5988027_18 ferredoxin like protein - - - 0.0000000000000000000000000000000000003086 144.0
TLS2_k127_5988027_19 cell redox homeostasis K02199 - - 0.00000000000000000000000000000000001262 147.0
TLS2_k127_5988027_2 SMART Metal-dependent phosphohydrolase, HD region K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 383.0
TLS2_k127_5988027_20 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000006296 147.0
TLS2_k127_5988027_21 XdhC and CoxI family - - - 0.0000000000000000000000000000000006959 133.0
TLS2_k127_5988027_22 Domain of unknown function (DUF4332) - - - 0.00000000000000000000000000000001571 132.0
TLS2_k127_5988027_23 Helix-turn-helix domain - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000004237 132.0
TLS2_k127_5988027_24 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944 - 0.0000000000000000000000000000003783 130.0
TLS2_k127_5988027_25 MobA-Related Protein K07141 - 2.7.7.76 0.00000000000000000000000000004324 130.0
TLS2_k127_5988027_26 heme binding K21472 - - 0.0000000000000000002689 102.0
TLS2_k127_5988027_27 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - - 0.000000000000005819 81.0
TLS2_k127_5988027_28 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.00000000001645 68.0
TLS2_k127_5988027_29 protein conserved in bacteria - - - 0.000000002412 69.0
TLS2_k127_5988027_3 DAHP synthetase I family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007146 385.0
TLS2_k127_5988027_30 Branched-chain amino acid transport protein (AzlD) - - - 0.0000000172 64.0
TLS2_k127_5988027_4 amidohydrolase K01436,K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 349.0
TLS2_k127_5988027_5 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003845 321.0
TLS2_k127_5988027_6 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 289.0
TLS2_k127_5988027_7 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002482 278.0
TLS2_k127_5988027_8 PFAM DAHP synthetase I K03856,K04516 - 2.5.1.54,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000244 278.0
TLS2_k127_5988027_9 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000831 271.0
TLS2_k127_606288_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1545.0
TLS2_k127_606288_1 Belongs to the aldehyde dehydrogenase family - - - 3.226e-209 664.0
TLS2_k127_606288_10 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006789 349.0
TLS2_k127_606288_11 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007291 332.0
TLS2_k127_606288_12 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008683 301.0
TLS2_k127_606288_13 Histidine kinase K02484 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 308.0
TLS2_k127_606288_14 Alpha/beta hydrolase family K21209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007071 298.0
TLS2_k127_606288_15 Binding-protein-dependent transport system inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 301.0
TLS2_k127_606288_16 RNA polymerase, sigma-24 subunit, ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001942 285.0
TLS2_k127_606288_17 TOBE domain K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001354 282.0
TLS2_k127_606288_18 Acetamidase formamidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002455 275.0
TLS2_k127_606288_19 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004394 279.0
TLS2_k127_606288_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 486.0
TLS2_k127_606288_20 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001977 267.0
TLS2_k127_606288_21 Capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002683 274.0
TLS2_k127_606288_22 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001626 259.0
TLS2_k127_606288_23 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) K16164 - 3.7.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000002714 254.0
TLS2_k127_606288_24 helix_turn_helix, Lux Regulon K07693 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001135 262.0
TLS2_k127_606288_25 HNH nucleases - - - 0.000000000000000000000000000000000000000000000000000000000000004421 231.0
TLS2_k127_606288_26 Permease K20469 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000001001 229.0
TLS2_k127_606288_27 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000001144 206.0
TLS2_k127_606288_28 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000002677 216.0
TLS2_k127_606288_29 Histidine kinase K07778 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000001242 216.0
TLS2_k127_606288_30 Protein of unknown function (DUF664) - - - 0.00000000000000000000000000000000000000000000000000000361 211.0
TLS2_k127_606288_31 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000001101 197.0
TLS2_k127_606288_32 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000009205 187.0
TLS2_k127_606288_33 penicillin-binding protein - - - 0.00000000000000000000000000000000000000000003088 179.0
TLS2_k127_606288_34 PIN domain - - - 0.0000000000000000000000000000000000000000002835 164.0
TLS2_k127_606288_35 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000131 147.0
TLS2_k127_606288_36 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000001518 142.0
TLS2_k127_606288_37 InterPro IPR014922 - - - 0.00000000000000000000000000000002665 139.0
TLS2_k127_606288_38 - - - - 0.000000000000000000000000000001316 129.0
TLS2_k127_606288_4 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000437 449.0
TLS2_k127_606288_40 Transcriptional regulator - - - 0.00000000000000000000006084 115.0
TLS2_k127_606288_41 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000002473 104.0
TLS2_k127_606288_42 FCD - - - 0.0000000000000000001509 98.0
TLS2_k127_606288_43 - - - - 0.00000000000000002158 87.0
TLS2_k127_606288_44 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000002325 96.0
TLS2_k127_606288_46 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 0.00000000000000281 87.0
TLS2_k127_606288_47 - - - - 0.000000000000005804 87.0
TLS2_k127_606288_48 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000006775 77.0
TLS2_k127_606288_49 Pfam:DUF385 - - - 0.00000000008601 69.0
TLS2_k127_606288_5 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 428.0
TLS2_k127_606288_51 oxidation-reduction process K09022 - 3.5.99.10 0.000000003147 69.0
TLS2_k127_606288_52 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.0000001318 65.0
TLS2_k127_606288_53 Nacht domain K12132 - 2.7.11.1 0.0000004862 60.0
TLS2_k127_606288_54 Polyketide cyclase / dehydrase and lipid transport - - - 0.000007993 53.0
TLS2_k127_606288_55 YqeY-like protein K09117 - - 0.00001985 54.0
TLS2_k127_606288_56 - - - - 0.00003155 55.0
TLS2_k127_606288_6 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 416.0
TLS2_k127_606288_7 Coenzyme A transferase K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 403.0
TLS2_k127_606288_8 Acyl CoA acetate 3-ketoacid CoA transferase beta subunit K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 374.0
TLS2_k127_606288_9 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 376.0
TLS2_k127_6088625_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K03520 - 1.2.5.3 3.106e-219 704.0
TLS2_k127_6088625_1 aminopeptidase activity K01301 - 3.4.17.21 6.317e-214 679.0
TLS2_k127_6088625_10 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 384.0
TLS2_k127_6088625_11 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 380.0
TLS2_k127_6088625_12 WYL domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 361.0
TLS2_k127_6088625_13 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004859 342.0
TLS2_k127_6088625_14 Coproporphyrinogen III oxidase K00228 - 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 336.0
TLS2_k127_6088625_15 Transport permease protein K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 321.0
TLS2_k127_6088625_16 Purine nucleoside phosphorylase K03784 GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009164,GO:0009987,GO:0015949,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0019686,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 311.0
TLS2_k127_6088625_17 Acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 310.0
TLS2_k127_6088625_18 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005599 296.0
TLS2_k127_6088625_19 Integral membrane protein TerC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000153 276.0
TLS2_k127_6088625_2 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 505.0
TLS2_k127_6088625_20 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001765 284.0
TLS2_k127_6088625_21 D-alanyl-D-alanine carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002192 285.0
TLS2_k127_6088625_22 PFAM CBS domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008659 267.0
TLS2_k127_6088625_23 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001809 237.0
TLS2_k127_6088625_24 of the major facilitator superfamily K08151 - - 0.00000000000000000000000000000000000000000000000000000000000000001271 248.0
TLS2_k127_6088625_25 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.0000000000000000000000000000000000000000000000000000000000009295 212.0
TLS2_k127_6088625_26 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000524 212.0
TLS2_k127_6088625_27 ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000003978 212.0
TLS2_k127_6088625_28 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000002719 207.0
TLS2_k127_6088625_29 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.00000000000000000000000000000000000000000000001169 184.0
TLS2_k127_6088625_3 PFAM Transketolase central region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 475.0
TLS2_k127_6088625_30 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000001921 173.0
TLS2_k127_6088625_31 Rubrerythrin K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000003975 170.0
TLS2_k127_6088625_32 Ferredoxin - - - 0.00000000000000000000000000000000000000000001054 175.0
TLS2_k127_6088625_33 Maf-like protein K06287 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000003037 172.0
TLS2_k127_6088625_34 amidohydrolase - - - 0.000000000000000000000000000000000000000002951 171.0
TLS2_k127_6088625_35 Transcriptional regulator - - - 0.00000000000000000000000000000000000000002059 162.0
TLS2_k127_6088625_36 KAP family P-loop domain - - - 0.00000000000000000000000000000000000000006968 174.0
TLS2_k127_6088625_37 Toxic component of a toxin-antitoxin (TA) module K07171 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.0000000000000000000000000000000000000001364 152.0
TLS2_k127_6088625_38 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000001989 171.0
TLS2_k127_6088625_39 Peptidase family S51 - - - 0.000000000000000000000000000000000000002082 158.0
TLS2_k127_6088625_4 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004483 486.0
TLS2_k127_6088625_40 - - - - 0.000000000000000000000000000000000000006865 149.0
TLS2_k127_6088625_41 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.0000000000000000000000000000000000009703 145.0
TLS2_k127_6088625_42 glyoxalase III activity - - - 0.0000000000000000000000000000006404 135.0
TLS2_k127_6088625_43 Toxic component of a toxin-antitoxin (TA) module. An RNase - GO:0008150,GO:0009605,GO:0009607,GO:0040008,GO:0043207,GO:0044403,GO:0044419,GO:0045927,GO:0048518,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0065007,GO:0075136 - 0.000000000000000000000000005552 115.0
TLS2_k127_6088625_44 PAS fold - - - 0.0000000000000000000000001268 124.0
TLS2_k127_6088625_45 FR47-like protein - - - 0.0000000000000000000000009143 119.0
TLS2_k127_6088625_47 DNA-binding transcription factor activity - - - 0.00000000000000000000004299 102.0
TLS2_k127_6088625_48 Activator of Hsp90 ATPase - - - 0.00000000000000000000009957 103.0
TLS2_k127_6088625_49 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000001018 114.0
TLS2_k127_6088625_5 Daunorubicin resistance ABC transporter ATP-binding subunit K01990,K18232 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 446.0
TLS2_k127_6088625_50 OsmC-like protein - - - 0.000000000000000007542 89.0
TLS2_k127_6088625_51 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000001317 85.0
TLS2_k127_6088625_52 - - - - 0.00000000000007026 82.0
TLS2_k127_6088625_53 PFAM pentapeptide repeat protein - - - 0.000000000003483 73.0
TLS2_k127_6088625_54 (FHA) domain - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.00000000001737 76.0
TLS2_k127_6088625_55 Uroporphyrinogen-III synthase K01719 - 4.2.1.75 0.00000001077 68.0
TLS2_k127_6088625_56 Clp amino terminal domain, pathogenicity island component - - - 0.000001689 53.0
TLS2_k127_6088625_6 AAA domain, putative AbiEii toxin, Type IV TA system K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 439.0
TLS2_k127_6088625_7 PFAM dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 424.0
TLS2_k127_6088625_8 Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 407.0
TLS2_k127_6088625_9 transport, permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005904 390.0
TLS2_k127_6125721_0 Phosphopantetheine attachment site - - - 0.0 1201.0
TLS2_k127_6125721_1 Aminotransferase class-III K00836 - 2.6.1.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004749 525.0
TLS2_k127_6125721_10 - - - - 0.00000008045 56.0
TLS2_k127_6125721_11 Protein of unknown function (DUF1761) - - - 0.0000006321 57.0
TLS2_k127_6125721_12 Involved in cell division - - - 0.00008879 48.0
TLS2_k127_6125721_2 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 507.0
TLS2_k127_6125721_3 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 391.0
TLS2_k127_6125721_4 HNH nucleases - - - 0.00000000000000000000000000000000000000000000000000007164 196.0
TLS2_k127_6125721_5 - - - - 0.0000000000000000000000000000000000000000000000000478 197.0
TLS2_k127_6125721_6 Ion transport 2 domain protein - - - 0.00000000000000000000000002861 116.0
TLS2_k127_6125721_7 AraC-like ligand binding domain - - - 0.0000000000000000000000004964 113.0
TLS2_k127_6125721_8 Peptidase C26 K01658,K01664 - 2.6.1.85,4.1.3.27 0.000000000000000002126 88.0
TLS2_k127_6125721_9 Ion channel - - - 0.0000000000000004129 89.0
TLS2_k127_6157336_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 428.0
TLS2_k127_6157336_1 Putative sugar-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000001798 228.0
TLS2_k127_6157336_2 - - - - 0.0000000000000000000000000000000000000000000000000000000002837 207.0
TLS2_k127_6157336_3 PTS system glucitol sorbitol-specific K02783 GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0051179,GO:0051234,GO:0071702 - 0.0000000000000000000000000000000000000000000000592 171.0
TLS2_k127_6157336_4 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000009656 166.0
TLS2_k127_6161561_1 Glycosyltransferase family 28 C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 392.0
TLS2_k127_6161561_10 Glycosyl transferases group 1 - - - 0.000000000000000000000000000006327 137.0
TLS2_k127_6161561_11 Polysaccharide pyruvyl transferase - - - 0.0000000000000000000000000001055 135.0
TLS2_k127_6161561_12 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000001467 134.0
TLS2_k127_6161561_13 Spore maturation protein CgeB K06320 - - 0.0000000000000000000000000004019 131.0
TLS2_k127_6161561_14 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000001032 101.0
TLS2_k127_6161561_15 bacterial-type flagellum-dependent cell motility K03641 - - 0.00000000000000001161 97.0
TLS2_k127_6161561_16 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000002121 97.0
TLS2_k127_6161561_17 antibiotic catabolic process K01174,K02238,K08651,K13277,K20276,K20486 - 3.1.31.1,3.4.21.66 0.00000000000000002174 97.0
TLS2_k127_6161561_18 Peptidase family M23 - - - 0.000000000000006312 87.0
TLS2_k127_6161561_19 Evidence 5 No homology to any previously reported sequences - - - 0.000000001075 70.0
TLS2_k127_6161561_2 COG2133 Glucose sorbosone dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008369 330.0
TLS2_k127_6161561_20 D-alanyl-D-alanine carboxypeptidase - - - 0.00000153 61.0
TLS2_k127_6161561_21 ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - 0.00003648 51.0
TLS2_k127_6161561_22 Cell shape determining protein MreB Mrl K03569 - - 0.0002709 52.0
TLS2_k127_6161561_23 FG-GAP repeat - - - 0.0006734 53.0
TLS2_k127_6161561_3 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000004787 239.0
TLS2_k127_6161561_4 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000001273 246.0
TLS2_k127_6161561_5 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000001697 228.0
TLS2_k127_6161561_6 SpoIID LytB domain protein - - - 0.000000000000000000000000000000000000000000000000004485 206.0
TLS2_k127_6161561_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000001618 199.0
TLS2_k127_6161561_8 Protein of unknown function (DUF3048) C-terminal domain - - - 0.000000000000000000000000000000003519 141.0
TLS2_k127_6161561_9 Glycosyl transferase, family 2 K13500 - 2.4.1.175,2.4.1.226 0.000000000000000000000000000000006378 149.0
TLS2_k127_620322_0 Oxidoreductase molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 423.0
TLS2_k127_620322_1 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 344.0
TLS2_k127_6248200_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 453.0
TLS2_k127_6248200_1 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377,K16554 - 1.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000001139 239.0
TLS2_k127_6263296_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 642.0
TLS2_k127_6263296_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003725 581.0
TLS2_k127_6263296_10 Uncharacterized protein family UPF0016 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000033 242.0
TLS2_k127_6263296_11 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000006802 231.0
TLS2_k127_6263296_12 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000005122 230.0
TLS2_k127_6263296_13 FR47-like protein K15520 GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701 2.3.1.189 0.00000000000000000000000000000000000000000000000000007933 199.0
TLS2_k127_6263296_14 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000001116 206.0
TLS2_k127_6263296_15 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000004156 176.0
TLS2_k127_6263296_16 Glycosyltransferase K08256 GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 0.00000000000000000000000000000000000000000000003149 187.0
TLS2_k127_6263296_17 anion-transporting ATPase - - - 0.00000000000000000000000000000000000000000007234 180.0
TLS2_k127_6263296_18 Bacterial lipid A biosynthesis acyltransferase K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.00000000000000000000000000000000000000003303 172.0
TLS2_k127_6263296_19 Histidine kinase - - - 0.0000000000000000000000000000000000000001867 166.0
TLS2_k127_6263296_2 elongation factor G K02355 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 573.0
TLS2_k127_6263296_20 EamA-like transporter family - - - 0.000000000000000000000000000000000000000235 160.0
TLS2_k127_6263296_21 AAA domain - - - 0.000000000000000000000000000000000001114 149.0
TLS2_k127_6263296_22 - - - - 0.00000000000000000000000000000000001799 145.0
TLS2_k127_6263296_23 Scavenger mRNA decapping enzyme C-term binding - - - 0.00000000000000000000000000000000229 140.0
TLS2_k127_6263296_24 COGs COG0534 Na -driven multidrug efflux pump K03327 - - 0.00000000000000000000000000000001182 142.0
TLS2_k127_6263296_26 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000005805 124.0
TLS2_k127_6263296_27 Patatin-like phospholipase K07001 - - 0.00000000000000000000000006759 120.0
TLS2_k127_6263296_28 - - - - 0.0000000000000000000000007654 113.0
TLS2_k127_6263296_29 Thioesterase superfamily - - - 0.000000000000000001724 99.0
TLS2_k127_6263296_3 Belongs to the citrate synthase family K01647 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008389 548.0
TLS2_k127_6263296_30 - - - - 0.00000000000000004548 82.0
TLS2_k127_6263296_31 G-D-S-L family - - - 0.00000000000005316 81.0
TLS2_k127_6263296_32 PFAM helix-turn-helix domain protein - - - 0.00000008257 58.0
TLS2_k127_6263296_33 Non-essential cell division protein that could be required for efficient cell constriction - - - 0.0001567 54.0
TLS2_k127_6263296_4 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 477.0
TLS2_k127_6263296_5 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 429.0
TLS2_k127_6263296_6 Two component transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002886 334.0
TLS2_k127_6263296_7 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005063 274.0
TLS2_k127_6263296_8 Mitochondrial small ribosomal subunit Rsm22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004598 280.0
TLS2_k127_6263296_9 transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002053 254.0
TLS2_k127_6282008_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 6.163e-253 802.0
TLS2_k127_6282008_1 asparagine synthase K01953 - 6.3.5.4 3.683e-229 731.0
TLS2_k127_6282008_10 Nucleoside-diphosphate-sugar pyrophosphorylase family protein K00978 - 2.7.7.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 355.0
TLS2_k127_6282008_11 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004233 369.0
TLS2_k127_6282008_12 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004842 312.0
TLS2_k127_6282008_13 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001093 237.0
TLS2_k127_6282008_14 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000112 218.0
TLS2_k127_6282008_15 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000009142 197.0
TLS2_k127_6282008_16 biosynthesis protein K08252,K16692 - 2.7.10.1 0.00000000000000000000000000000000000000000001582 183.0
TLS2_k127_6282008_18 Acetyltransferase (GNAT) domain K03817 - - 0.000000000000000000000000000000217 130.0
TLS2_k127_6282008_19 NUDIX domain - - - 0.000000000000000000000000000632 121.0
TLS2_k127_6282008_2 Heparinase II/III N-terminus - - - 7.588e-217 693.0
TLS2_k127_6282008_20 N-terminal Region. This family is found at the N-terminus of a number of subtilisins. It is cleaved prior to activation of the enzyme - - - 0.00000000000000005935 95.0
TLS2_k127_6282008_21 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000001573 87.0
TLS2_k127_6282008_22 deoxyhypusine monooxygenase activity K03301 - - 0.000000000000004495 90.0
TLS2_k127_6282008_23 rRNA binding - - - 0.000000004797 70.0
TLS2_k127_6282008_3 Ion channel K10716 - - 1.743e-202 646.0
TLS2_k127_6282008_4 epimerase dehydratase K08678 - 4.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 482.0
TLS2_k127_6282008_5 glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004797 474.0
TLS2_k127_6282008_6 Right handed beta helix region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008009 458.0
TLS2_k127_6282008_7 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 446.0
TLS2_k127_6282008_8 homoserine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 423.0
TLS2_k127_6282008_9 UDP binding domain K00066 - 1.1.1.132 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004885 432.0
TLS2_k127_6309499_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 622.0
TLS2_k127_6309499_1 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004907 590.0
TLS2_k127_6309499_10 Threonyl and Alanyl tRNA synthetase second additional domain K07050 - - 0.0000000000000000000000000000000000000000000000000000000000000007904 243.0
TLS2_k127_6309499_11 DinB family - - - 0.000000000000000000000000000000000000000000000000000000000000001516 228.0
TLS2_k127_6309499_12 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000001338 222.0
TLS2_k127_6309499_13 - - - - 0.0000000000000000000000000000000000000000000000000000004509 202.0
TLS2_k127_6309499_14 PIN domain - - - 0.00000000000000000000000000000000000000000009561 165.0
TLS2_k127_6309499_15 Histidine kinase - - - 0.0000000000000000000000000000000000000002744 167.0
TLS2_k127_6309499_16 AI-2E family transporter - - - 0.0000000000000000000000000000004792 137.0
TLS2_k127_6309499_17 Histidine kinase - - - 0.000000000000000000000000003959 128.0
TLS2_k127_6309499_18 - - - - 0.000000000000000001862 90.0
TLS2_k127_6309499_19 Protein of unknown function (DUF3263) - - - 0.0000000000000003441 82.0
TLS2_k127_6309499_2 TAP-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003398 551.0
TLS2_k127_6309499_21 - - - - 0.00000005767 57.0
TLS2_k127_6309499_22 cell envelope-related transcriptional attenuator - - - 0.0000000618 63.0
TLS2_k127_6309499_23 acyl-CoA dehydrogenase activity - - - 0.00002741 48.0
TLS2_k127_6309499_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007672 430.0
TLS2_k127_6309499_4 Belongs to the long-chain O-acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 378.0
TLS2_k127_6309499_5 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 362.0
TLS2_k127_6309499_6 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 319.0
TLS2_k127_6309499_7 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 296.0
TLS2_k127_6309499_8 Phage integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004884 281.0
TLS2_k127_6309499_9 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001315 256.0
TLS2_k127_6314577_0 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004333 423.0
TLS2_k127_6314577_1 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 384.0
TLS2_k127_6330820_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 1.299e-283 891.0
TLS2_k127_6330820_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 1.906e-277 888.0
TLS2_k127_6330820_10 ABC transporter (Permease) K02050 - - 0.000000000000000000000000000000000000000000000000000000000772 211.0
TLS2_k127_6330820_11 ABC transporter (Permease) K02050 - - 0.000000000000000000000000000000000000000000000000000000001901 211.0
TLS2_k127_6330820_12 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000005853 197.0
TLS2_k127_6330820_13 Glycine/sarcosine/betaine reductase component B subunits K10671 - 1.21.4.2 0.0000000000000000000000000000000000000000000000000004581 201.0
TLS2_k127_6330820_14 Toxic component of a toxin-antitoxin (TA) module K07171 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000007651 177.0
TLS2_k127_6330820_15 Glycine/sarcosine/betaine reductase component B subunits K10671 - 1.21.4.2 0.000000000000000000000000000000000000000000004712 182.0
TLS2_k127_6330820_16 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000005148 185.0
TLS2_k127_6330820_17 Isochorismatase family K09020 - 3.5.1.110 0.000000000000000000000000000000000000000002135 162.0
TLS2_k127_6330820_18 ABC transporter (Periplasmic binding protein) K02051 - - 0.00000000000000000000000000000000000000002173 168.0
TLS2_k127_6330820_19 amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000000000000000006598 164.0
TLS2_k127_6330820_2 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520,K19187 - 1.2.5.3,1.5.99.14 3.454e-213 686.0
TLS2_k127_6330820_20 HAD-hyrolase-like K07025 - - 0.00000000000000000000000000000000000001194 164.0
TLS2_k127_6330820_21 Alpha/beta hydrolase of unknown function (DUF1100) - - - 0.000000000000000000000000000001227 139.0
TLS2_k127_6330820_22 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10672 - 1.21.4.2 0.0000000000000000000001381 99.0
TLS2_k127_6330820_23 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.000000000000005273 87.0
TLS2_k127_6330820_3 Glycine reductase complex component B subunit gamma K10672 - 1.21.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 337.0
TLS2_k127_6330820_4 Belongs to the ABC transporter superfamily K02031,K02032,K13896,K19229,K19230 GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008144,GO:0008150,GO:0008324,GO:0008519,GO:0009987,GO:0015075,GO:0015101,GO:0015203,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0017076,GO:0022857,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071804,GO:0071805,GO:0072488,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902047 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006792 326.0
TLS2_k127_6330820_5 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005254 304.0
TLS2_k127_6330820_6 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007237 293.0
TLS2_k127_6330820_7 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001126 274.0
TLS2_k127_6330820_8 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000113 259.0
TLS2_k127_6330820_9 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000001043 245.0
TLS2_k127_6338955_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 366.0
TLS2_k127_6338955_1 Elongation factor SelB, winged helix K03833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007211 374.0
TLS2_k127_6338955_2 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 330.0
TLS2_k127_6338955_3 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000001058 204.0
TLS2_k127_6338955_4 Iron-sulphur cluster biosynthesis K13628 - - 0.000000000000000000000000000000000002276 142.0
TLS2_k127_6338955_5 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000001495 112.0
TLS2_k127_6338955_6 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01069 - 3.1.2.6 0.000000000000000000000001898 110.0
TLS2_k127_6338955_7 RDD family - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000009899 103.0
TLS2_k127_6339771_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 609.0
TLS2_k127_6339771_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004251 611.0
TLS2_k127_6339771_10 membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000005456 228.0
TLS2_k127_6339771_11 PFAM LemA K03744 - - 0.0000000000000000000000000000000000000000000000000000001455 203.0
TLS2_k127_6339771_12 Methylmalonyl-CoA mutase K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000003572 192.0
TLS2_k127_6339771_13 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000009191 187.0
TLS2_k127_6339771_14 Lysyl oxidase - - - 0.00000000000000000000000000000000000000000000002501 184.0
TLS2_k127_6339771_15 thioesterase - - - 0.00000000000000000000001492 116.0
TLS2_k127_6339771_16 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000000000000001211 96.0
TLS2_k127_6339771_17 ParE toxin of type II toxin-antitoxin system, parDE - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000001084 88.0
TLS2_k127_6339771_18 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.000000008711 59.0
TLS2_k127_6339771_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 515.0
TLS2_k127_6339771_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 464.0
TLS2_k127_6339771_4 Quinolinate synthetase A protein K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 451.0
TLS2_k127_6339771_5 Fumarate reductase flavoprotein C-term K00278 - 1.4.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007805 375.0
TLS2_k127_6339771_6 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 371.0
TLS2_k127_6339771_7 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 306.0
TLS2_k127_6339771_8 belongs to the nudix hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006322 272.0
TLS2_k127_6339771_9 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000000000000001533 212.0
TLS2_k127_637161_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 517.0
TLS2_k127_637161_1 Endoribonuclease that initiates mRNA decay K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000689 518.0
TLS2_k127_637161_10 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000003729 151.0
TLS2_k127_637161_11 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000001463 112.0
TLS2_k127_637161_12 Belongs to the SAICAR synthetase family K01923,K01945 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.0000006805 52.0
TLS2_k127_637161_13 LysM domain protein - - - 0.000002591 56.0
TLS2_k127_637161_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 492.0
TLS2_k127_637161_3 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 456.0
TLS2_k127_637161_4 Belongs to the CinA family K03742 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007096 344.0
TLS2_k127_637161_5 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K14441 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 345.0
TLS2_k127_637161_6 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000002423 222.0
TLS2_k127_637161_7 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000008262 226.0
TLS2_k127_637161_8 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000001162 193.0
TLS2_k127_637161_9 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000006183 152.0
TLS2_k127_647338_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 3.6.3.14 2.897e-211 667.0
TLS2_k127_647338_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.6.3.14 5.334e-207 662.0
TLS2_k127_647338_10 Homoserine dehydrogenase K00003,K12524 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.3,2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 421.0
TLS2_k127_647338_11 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 414.0
TLS2_k127_647338_12 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 406.0
TLS2_k127_647338_13 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 359.0
TLS2_k127_647338_14 N-acetylglucosaminylinositol deacetylase activity K18455 - 3.5.1.115 0.00000000000000000000000000000000000000000000000000000000000000000000000000004078 273.0
TLS2_k127_647338_15 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002706 258.0
TLS2_k127_647338_16 Psort location CytoplasmicMembrane, score 10.00 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002995 260.0
TLS2_k127_647338_17 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000007144 252.0
TLS2_k127_647338_18 DNA ligase D DNA polymerase LigD K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000001894 233.0
TLS2_k127_647338_19 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000001772 237.0
TLS2_k127_647338_2 PFAM peptidase M13 K07386 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 572.0
TLS2_k127_647338_20 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000003025 199.0
TLS2_k127_647338_21 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000001953 193.0
TLS2_k127_647338_22 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000000000000000000007474 171.0
TLS2_k127_647338_23 LuxR family transcriptional regulator - - - 0.000000000000000000000000000000000002683 158.0
TLS2_k127_647338_24 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000004485 152.0
TLS2_k127_647338_25 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000002943 143.0
TLS2_k127_647338_26 transcriptional regulator - - - 0.000000000000000000000000000000004289 141.0
TLS2_k127_647338_27 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000003381 133.0
TLS2_k127_647338_28 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000007164 120.0
TLS2_k127_647338_29 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000003228 122.0
TLS2_k127_647338_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 537.0
TLS2_k127_647338_30 Binds the 23S rRNA K02909 - - 0.000000000000000000000000004885 113.0
TLS2_k127_647338_31 Yqey-like protein K09117 - - 0.000000000000000000000000006485 120.0
TLS2_k127_647338_32 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000001421 116.0
TLS2_k127_647338_33 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000001953 111.0
TLS2_k127_647338_34 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000003781 98.0
TLS2_k127_647338_35 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000005863 85.0
TLS2_k127_647338_38 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0001172 44.0
TLS2_k127_647338_39 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.000124 51.0
TLS2_k127_647338_4 ABC transporter K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 476.0
TLS2_k127_647338_5 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009194 466.0
TLS2_k127_647338_6 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002843 478.0
TLS2_k127_647338_7 Aminotransferase class-III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004071 453.0
TLS2_k127_647338_8 ATPases associated with a variety of cellular activities K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000053 445.0
TLS2_k127_647338_9 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003928 433.0
TLS2_k127_6525997_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 9.513e-299 951.0
TLS2_k127_6525997_1 xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 1.735e-221 720.0
TLS2_k127_6525997_10 Short-chain Dehydrogenase reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000435 293.0
TLS2_k127_6525997_11 Branched-chain amino acid transport system / permease component K01997,K11956 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 302.0
TLS2_k127_6525997_12 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000009537 276.0
TLS2_k127_6525997_13 abc transporter atp-binding protein K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001224 274.0
TLS2_k127_6525997_14 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003566 254.0
TLS2_k127_6525997_15 NADH:flavin oxidoreductase / NADH oxidase family K10680 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005464 264.0
TLS2_k127_6525997_16 ATPases associated with a variety of cellular activities K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000002505 251.0
TLS2_k127_6525997_17 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000001277 230.0
TLS2_k127_6525997_18 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000006694 228.0
TLS2_k127_6525997_19 Amidohydrolase K10220 - 4.2.1.83 0.000000000000000000000000000000000000000000000000000000000003039 222.0
TLS2_k127_6525997_2 xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 1.508e-219 707.0
TLS2_k127_6525997_20 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000000000000000000000002535 220.0
TLS2_k127_6525997_21 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000003391 213.0
TLS2_k127_6525997_22 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000007305 203.0
TLS2_k127_6525997_23 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000001806 192.0
TLS2_k127_6525997_24 oxidation-reduction process - - - 0.000000000000000000000000000000000000000000000001281 191.0
TLS2_k127_6525997_25 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000347 188.0
TLS2_k127_6525997_26 TIGRFAM phenylacetate-CoA oxygenase, PaaJ subunit K02612 - - 0.0000000000000000000000000000000000000000000004943 183.0
TLS2_k127_6525997_27 PAC2 family - - - 0.000000000000000000000000000000000000000000006104 181.0
TLS2_k127_6525997_28 transcriptional regulator - - - 0.000000000000000000000000000000000000000002684 167.0
TLS2_k127_6525997_29 membrane K08981 - - 0.000000000000000000000000000000000000000003936 177.0
TLS2_k127_6525997_3 Phenylacetate-CoA oxygenase K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 503.0
TLS2_k127_6525997_30 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000002543 164.0
TLS2_k127_6525997_31 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000001701 154.0
TLS2_k127_6525997_32 - - - - 0.00000000000000000000000000000005312 130.0
TLS2_k127_6525997_33 Acetylornithine deacetylase - - - 0.000000000000000000000000000000201 139.0
TLS2_k127_6525997_34 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000007511 135.0
TLS2_k127_6525997_35 Phenylacetic acid degradation B K02610 - - 0.00000000000000000000000000003097 132.0
TLS2_k127_6525997_36 Membrane-flanked domain K09167 - - 0.00000000000000000000000001845 115.0
TLS2_k127_6525997_37 RNA recognition motif - - - 0.00000000000000000000001785 115.0
TLS2_k127_6525997_38 Subtilisin inhibitor-like - - - 0.00000000000000005692 88.0
TLS2_k127_6525997_39 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.000000000000007677 79.0
TLS2_k127_6525997_4 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005504 461.0
TLS2_k127_6525997_40 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls - - - 0.000000000004965 74.0
TLS2_k127_6525997_41 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000001408 70.0
TLS2_k127_6525997_42 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000005477 75.0
TLS2_k127_6525997_43 EamA-like transporter family - - - 0.000000002079 68.0
TLS2_k127_6525997_5 Dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 353.0
TLS2_k127_6525997_6 Phenylacetate-CoA oxygenase reductase, PaaK subunit K02613 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003849 351.0
TLS2_k127_6525997_7 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007412 342.0
TLS2_k127_6525997_8 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 342.0
TLS2_k127_6525997_9 PFAM phenylacetic acid catabolic family protein K02611 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 302.0
TLS2_k127_6624389_0 malic enzyme K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 3.276e-255 809.0
TLS2_k127_6624389_1 Peptidase family M1 domain K08776 - - 8.081e-227 734.0
TLS2_k127_6624389_10 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000001365 203.0
TLS2_k127_6624389_11 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000002071 176.0
TLS2_k127_6624389_12 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.000000000000000000000000000000000008362 147.0
TLS2_k127_6624389_13 Protein of unknown function (DUF559) - - - 0.00000000000000000000000001876 121.0
TLS2_k127_6624389_14 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03073 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000001218 66.0
TLS2_k127_6624389_15 Helix-turn-helix XRE-family like proteins - - - 0.0003402 51.0
TLS2_k127_6624389_2 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 1.367e-198 629.0
TLS2_k127_6624389_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 426.0
TLS2_k127_6624389_4 Phosphoserine phosphatase K01079 GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 412.0
TLS2_k127_6624389_5 cystathione gamma lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 401.0
TLS2_k127_6624389_6 ROK family K00886 - 2.7.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002225 276.0
TLS2_k127_6624389_7 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004277 273.0
TLS2_k127_6624389_8 Participates in transcription elongation, termination and antitermination K02601 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000001535 246.0
TLS2_k127_6624389_9 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000003131 205.0
TLS2_k127_6674346_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000004601 221.0
TLS2_k127_6674346_1 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000005441 212.0
TLS2_k127_6674346_2 domain protein - - - 0.00000000000000000007758 90.0
TLS2_k127_673204_0 e3 binding domain K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 378.0
TLS2_k127_673204_1 Belongs to the peptidase S8 family - - - 0.000008845 55.0
TLS2_k127_6751324_0 DEAD/H associated K03724 - - 0.0 1455.0
TLS2_k127_6751324_1 FAD linked oxidases, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006666 496.0
TLS2_k127_6751324_10 Belongs to the DapB family K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000007162 224.0
TLS2_k127_6751324_11 PFAM Thioredoxin domain K05838 - - 0.000000000000000000000000000000000000000000000000000002099 201.0
TLS2_k127_6751324_12 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000358 192.0
TLS2_k127_6751324_13 MFS_1 like family - - - 0.000000000000000000000000000000000000000000000002964 188.0
TLS2_k127_6751324_14 diguanylate cyclase (GGDEF) domain - - - 0.000000000000000000000000000000000000000000003863 171.0
TLS2_k127_6751324_15 DinB superfamily - - - 0.0000000000000000000000000000000000000002734 158.0
TLS2_k127_6751324_16 Formamidopyrimidine-DNA glycosylase H2TH domain K05522 - 4.2.99.18 0.00000000000000000000000000000000000003791 154.0
TLS2_k127_6751324_17 Protein of unknown function (DUF4230) - - - 0.0000000000000000004311 96.0
TLS2_k127_6751324_18 associated with various cellular activities K09882 - 6.6.1.2 0.0000000000001965 81.0
TLS2_k127_6751324_2 Domain of unknown function (DUF4032) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 500.0
TLS2_k127_6751324_3 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 500.0
TLS2_k127_6751324_4 Aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 452.0
TLS2_k127_6751324_5 Elongator protein 3 MiaB NifB K11779 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 419.0
TLS2_k127_6751324_6 Insulinase (Peptidase family M16) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 390.0
TLS2_k127_6751324_7 cytokinin biosynthetic process K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 314.0
TLS2_k127_6751324_8 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004534 277.0
TLS2_k127_6751324_9 TIGRFAM membrane complex biogenesis protein, BtpA family K06971 - - 0.000000000000000000000000000000000000000000000000000000000000006168 235.0
TLS2_k127_6755622_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006745 471.0
TLS2_k127_6755622_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 375.0
TLS2_k127_6755622_10 ABC-2 family transporter protein K01992 - - 0.000001546 54.0
TLS2_k127_6755622_11 (FHA) domain - - - 0.0002852 53.0
TLS2_k127_6755622_2 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007911 341.0
TLS2_k127_6755622_3 ABC-type multidrug transport system, ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 298.0
TLS2_k127_6755622_4 Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP K07067 - 2.7.7.85 0.00000000000000000000000000000000000000000000000000000000000000000000000005477 277.0
TLS2_k127_6755622_5 cytochrome P-450 K00493 - 1.14.14.1 0.00000000000000000000000000000000000000000000000000000000000001791 224.0
TLS2_k127_6755622_6 RNA 2'-O ribose methyltransferase substrate binding K03218 - 2.1.1.185 0.000000000000000000000000000000000000000001521 165.0
TLS2_k127_6755622_7 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000001105 160.0
TLS2_k127_6755622_8 CarD-like/TRCF domain K07736 - - 0.0000000000000000000000000000002663 141.0
TLS2_k127_6755622_9 - - - - 0.0000003037 63.0
TLS2_k127_678237_0 Belongs to the GcvT family - - - 0.0 1100.0
TLS2_k127_678237_1 Domain of unknown function (DUF4445) - - - 2.39e-235 748.0
TLS2_k127_678237_10 COG1410 Methionine synthase I, cobalamin-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003653 404.0
TLS2_k127_678237_11 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 369.0
TLS2_k127_678237_12 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 362.0
TLS2_k127_678237_13 COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain K00544,K00548 - 2.1.1.13,2.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008414 310.0
TLS2_k127_678237_14 Electron transfer flavoprotein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002156 289.0
TLS2_k127_678237_15 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004529 266.0
TLS2_k127_678237_16 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) K05845 - - 0.0000000000000000000000000000000000000000000000000000000000002977 234.0
TLS2_k127_678237_17 gntR family - - - 0.0000000000000000000000000000000000000000000000000000000000008992 218.0
TLS2_k127_678237_18 Protein of unknown function (DUF1638) - - - 0.0000000000000000000000000000000000000000000000000000000000009582 228.0
TLS2_k127_678237_19 Superoxide dismutase K00518 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000009648 205.0
TLS2_k127_678237_2 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01907 - 6.2.1.16 5.874e-233 737.0
TLS2_k127_678237_20 COG0685 5,10-methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000001761 224.0
TLS2_k127_678237_21 Binding-protein-dependent transport system inner membrane component K05846 - - 0.00000000000000000000000000000000000000000000000000002294 209.0
TLS2_k127_678237_22 Binding-protein-dependent transport system inner membrane component K05846 - - 0.0000000000000000000000000000000000000000001251 176.0
TLS2_k127_678237_23 Bacterial transcriptional regulator - - - 0.0000000000000000000000000000000000142 145.0
TLS2_k127_678237_24 Protein of unknown function (DUF3048) C-terminal domain - - - 0.0000000000000000000000000000001761 137.0
TLS2_k127_678237_25 CGNR zinc finger - - - 0.000000000000000000000001009 122.0
TLS2_k127_678237_26 Molybdopterin oxidoreductase - - - 0.000000000000000000000002556 110.0
TLS2_k127_678237_27 PFAM Peptidase S24 S26A S26B, conserved region K03100 - 3.4.21.89 0.0000000006695 65.0
TLS2_k127_678237_28 PFAM amino acid-binding ACT domain protein - - - 0.000000006659 66.0
TLS2_k127_678237_3 Molybdopterin oxidoreductase K00123 - 1.17.1.9 1.022e-230 726.0
TLS2_k127_678237_4 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 2.98e-223 706.0
TLS2_k127_678237_5 GTP-binding protein K06207 - - 8.265e-203 655.0
TLS2_k127_678237_6 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00122,K00335 - 1.17.1.9,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009354 609.0
TLS2_k127_678237_7 PFAM chorismate K01665,K03342 - 2.6.1.85,4.1.3.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003592 512.0
TLS2_k127_678237_8 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01739,K01761 - 2.5.1.48,4.4.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 456.0
TLS2_k127_678237_9 2Fe-2S iron-sulfur cluster binding domain K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 424.0
TLS2_k127_6795516_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564 2.7.4.1 1.966e-225 722.0
TLS2_k127_6795516_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004294 612.0
TLS2_k127_6795516_10 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000002831 101.0
TLS2_k127_6795516_11 Transcriptional regulator - - - 0.00000000000000519 84.0
TLS2_k127_6795516_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006147 540.0
TLS2_k127_6795516_3 Winged helix DNA-binding domain K09927 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 416.0
TLS2_k127_6795516_4 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 393.0
TLS2_k127_6795516_5 Belongs to the peptidase S51 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001221 267.0
TLS2_k127_6795516_6 PFAM Phage tail sheath protein K06907 - - 0.000000000000000000000000000000000000000000000000001092 202.0
TLS2_k127_6795516_7 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000009488 191.0
TLS2_k127_6795516_8 glyoxalase bleomycin resistance protein dioxygenase - GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 - 0.00000000000000000000000000000000000000000009474 164.0
TLS2_k127_6795516_9 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000005126 110.0
TLS2_k127_6812637_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.0 1070.0
TLS2_k127_6812637_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 7.639e-228 715.0
TLS2_k127_6812637_10 PFAM Bacterial-like globin K06886 - - 0.0000000000000000000000005456 112.0
TLS2_k127_6812637_11 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000002641 120.0
TLS2_k127_6812637_12 Pfam:DUF385 - - - 0.00000000000000000000009556 104.0
TLS2_k127_6812637_13 - - - - 0.000000000000000004113 99.0
TLS2_k127_6812637_14 Subtilase family - - - 0.000000000000001463 91.0
TLS2_k127_6812637_15 Roadblock/LC7 domain K07131 - - 0.000001044 60.0
TLS2_k127_6812637_16 Cupin domain - - - 0.000009327 55.0
TLS2_k127_6812637_17 Dodecin K09165 - - 0.00008883 52.0
TLS2_k127_6812637_2 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 337.0
TLS2_k127_6812637_3 Enoyl-CoA hydratase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000008988 283.0
TLS2_k127_6812637_4 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004588 255.0
TLS2_k127_6812637_5 endonuclease III K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000003159 228.0
TLS2_k127_6812637_6 MafB19-like deaminase K01485 - 3.5.4.1 0.00000000000000000000000000000000000000000000000000000000004832 210.0
TLS2_k127_6812637_7 Putative glycosyl hydrolase domain - - - 0.00000000000000000000000000000000000000000000000000000000009692 231.0
TLS2_k127_6812637_8 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000005256 196.0
TLS2_k127_6812637_9 TIGRFAM small GTP-binding protein K06945 - - 0.00000000000000000000000000000000000000000001342 168.0
TLS2_k127_6851281_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1261.0
TLS2_k127_6851281_1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 9.028e-316 1002.0
TLS2_k127_6851281_10 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000501 178.0
TLS2_k127_6851281_11 Lipoate-protein ligase - - - 0.0000000000000000000000000000000000000002256 159.0
TLS2_k127_6851281_12 Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase K01845,K07257 - 5.4.3.8 0.000000000000000000000000001586 117.0
TLS2_k127_6851281_13 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.00000000000000000000001723 103.0
TLS2_k127_6851281_14 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.00000000000000000000001913 110.0
TLS2_k127_6851281_15 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.00000000000000007122 92.0
TLS2_k127_6851281_16 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0002709 54.0
TLS2_k127_6851281_2 ABC transporter K06147 - - 3.005e-219 712.0
TLS2_k127_6851281_3 4Fe-4S binding domain K07307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 486.0
TLS2_k127_6851281_4 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779,K11784 - 1.21.98.1,2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008333 396.0
TLS2_k127_6851281_5 Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC K18704,K21285 - 2.7.8.14,2.7.8.44,2.7.8.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009525 323.0
TLS2_k127_6851281_6 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 306.0
TLS2_k127_6851281_7 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000008368 244.0
TLS2_k127_6851281_8 (mono)amine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000001203 226.0
TLS2_k127_6851281_9 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000000000000000000000004932 214.0
TLS2_k127_6888743_0 Dehydrogenase E1 component K21416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 477.0
TLS2_k127_6888743_1 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004803 362.0
TLS2_k127_6888743_2 Transketolase, pyrimidine binding domain K21417 - - 0.000000000000000000000000000001046 131.0
TLS2_k127_6901022_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1224.0
TLS2_k127_6901022_1 Non-ribosomal peptide synthetase modules and related proteins - - - 1.233e-223 761.0
TLS2_k127_6901022_10 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000005057 246.0
TLS2_k127_6901022_11 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000001971 231.0
TLS2_k127_6901022_12 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000007159 233.0
TLS2_k127_6901022_13 Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000002645 218.0
TLS2_k127_6901022_14 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000002073 213.0
TLS2_k127_6901022_15 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000002532 214.0
TLS2_k127_6901022_16 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.000000000000000000000000000000000000000000000000000005363 212.0
TLS2_k127_6901022_17 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.000000000000000000000000000000000000000000000000009474 187.0
TLS2_k127_6901022_18 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000001943 178.0
TLS2_k127_6901022_19 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000000000000000000000000659 130.0
TLS2_k127_6901022_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 457.0
TLS2_k127_6901022_20 Helix-hairpin-helix DNA-binding motif class 1 - - - 0.00000000000000000000000004675 110.0
TLS2_k127_6901022_21 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 GO:0008150,GO:0040007 - 0.000000000000000000002084 100.0
TLS2_k127_6901022_22 4'-phosphopantetheinyl transferase superfamily K06133 - - 0.0000000000000002535 92.0
TLS2_k127_6901022_23 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000001278 72.0
TLS2_k127_6901022_3 Belongs to the CarA family K01955,K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006108 406.0
TLS2_k127_6901022_4 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009246 362.0
TLS2_k127_6901022_5 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009512 347.0
TLS2_k127_6901022_6 ABC-type multidrug transport system ATPase and permease K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 335.0
TLS2_k127_6901022_7 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 328.0
TLS2_k127_6901022_8 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 294.0
TLS2_k127_6901022_9 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000008481 253.0
TLS2_k127_6920377_0 Belongs to the catalase family K03781 - 1.11.1.6 8.37e-296 912.0
TLS2_k127_6920377_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 448.0
TLS2_k127_6920377_10 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 319.0
TLS2_k127_6920377_11 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004967 282.0
TLS2_k127_6920377_12 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002142 267.0
TLS2_k127_6920377_13 Periplasmic binding protein domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001229 276.0
TLS2_k127_6920377_14 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000207 252.0
TLS2_k127_6920377_15 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000001229 254.0
TLS2_k127_6920377_16 Activator of Hsp90 ATPase 1 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001598 237.0
TLS2_k127_6920377_17 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000005978 248.0
TLS2_k127_6920377_18 calcium, potassium:sodium antiporter activity K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000002291 241.0
TLS2_k127_6920377_19 PFAM amidohydrolase 2 K03392 - 4.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000001334 237.0
TLS2_k127_6920377_2 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 442.0
TLS2_k127_6920377_20 Amidohydrolase K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000003112 239.0
TLS2_k127_6920377_21 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000001437 228.0
TLS2_k127_6920377_22 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000001104 218.0
TLS2_k127_6920377_23 ABC-type sugar transport system, permease component K02026 - - 0.000000000000000000000000000000000000000000000000000000791 215.0
TLS2_k127_6920377_24 Protein of unknown function (DUF1211) - - - 0.000000000000000000000000000000000000000000000000000006116 215.0
TLS2_k127_6920377_25 import. Responsible for energy coupling to the transport system - - - 0.000000000000000000000000000000000000000000000000000007688 217.0
TLS2_k127_6920377_26 Domain of unknown function (DUF4397) - - - 0.00000000000000000000000000000000000000000000000001366 193.0
TLS2_k127_6920377_27 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000001527 190.0
TLS2_k127_6920377_28 transcriptional regulator, ArsR family - - - 0.00000000000000000000000000000000000000000000000005138 187.0
TLS2_k127_6920377_29 Cro/C1-type HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000002056 175.0
TLS2_k127_6920377_3 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 425.0
TLS2_k127_6920377_30 PFAM binding-protein-dependent transport systems inner membrane component K02025,K05814 - - 0.000000000000000000000000000000000000007248 158.0
TLS2_k127_6920377_31 Cupin domain - - - 0.00000000000000000000000000000000000001931 156.0
TLS2_k127_6920377_32 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000002907 145.0
TLS2_k127_6920377_33 Hemerythrin HHE cation binding domain K01534 - 3.6.3.3,3.6.3.5 0.00000000000000000000000000000000005256 138.0
TLS2_k127_6920377_34 Oxidoreductase K10219 - 1.1.1.312 0.0000000000000000000000000000002817 139.0
TLS2_k127_6920377_35 Phospholipase_D-nuclease N-terminal - - - 0.0000000000000000000000000000007927 125.0
TLS2_k127_6920377_36 peptidase C60 sortase A and B - - - 0.00000000000000000000000000001897 130.0
TLS2_k127_6920377_37 - - - - 0.000000000000000000000000002215 118.0
TLS2_k127_6920377_38 OsmC-like protein - - - 0.0000000000000000000000001328 116.0
TLS2_k127_6920377_39 - K01992 - - 0.0000000000000000000001418 108.0
TLS2_k127_6920377_4 Exporter of polyketide antibiotics K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 435.0
TLS2_k127_6920377_40 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000005817 88.0
TLS2_k127_6920377_41 PFAM Carboxymuconolactone decarboxylase - - - 0.0001999 50.0
TLS2_k127_6920377_42 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0002709 52.0
TLS2_k127_6920377_5 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 436.0
TLS2_k127_6920377_6 Belongs to the binding-protein-dependent transport system permease family K10440,K10441 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008598 387.0
TLS2_k127_6920377_7 VIT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 363.0
TLS2_k127_6920377_8 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 361.0
TLS2_k127_6920377_9 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 376.0
TLS2_k127_7012373_0 Aminotransferase K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 503.0
TLS2_k127_7012373_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 424.0
TLS2_k127_7012373_10 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000006241 237.0
TLS2_k127_7012373_11 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000002926 229.0
TLS2_k127_7012373_12 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000004869 214.0
TLS2_k127_7012373_13 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000009912 203.0
TLS2_k127_7012373_14 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000006765 202.0
TLS2_k127_7012373_15 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000001646 197.0
TLS2_k127_7012373_16 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000029 190.0
TLS2_k127_7012373_17 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000005628 180.0
TLS2_k127_7012373_18 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000001742 162.0
TLS2_k127_7012373_19 Cell envelope-related transcriptional attenuator domain - - - 0.0000000000000000000000000000000000000000001942 178.0
TLS2_k127_7012373_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005925 419.0
TLS2_k127_7012373_20 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000000001564 163.0
TLS2_k127_7012373_21 Ribosomal protein S9/S16 K02996 - - 0.00000000000000000000000000000000000000007518 159.0
TLS2_k127_7012373_22 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000002051 156.0
TLS2_k127_7012373_23 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000004179 145.0
TLS2_k127_7012373_24 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000009157 118.0
TLS2_k127_7012373_25 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.00000000000000000000000004421 108.0
TLS2_k127_7012373_26 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000001668 108.0
TLS2_k127_7012373_27 phosphatase activity K07025 - - 0.00000000000000000000000656 113.0
TLS2_k127_7012373_28 GDP-mannose mannosyl hydrolase activity K03574 - 3.6.1.55 0.000000000000000000000007733 116.0
TLS2_k127_7012373_29 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000002516 94.0
TLS2_k127_7012373_3 Pantothenic acid kinase K00867 GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 414.0
TLS2_k127_7012373_30 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000388 82.0
TLS2_k127_7012373_31 Ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000006866 83.0
TLS2_k127_7012373_32 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000006515 73.0
TLS2_k127_7012373_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 347.0
TLS2_k127_7012373_5 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000004362 265.0
TLS2_k127_7012373_6 Metallopeptidase family M24 K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000002844 267.0
TLS2_k127_7012373_7 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001277 258.0
TLS2_k127_7012373_8 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000001388 250.0
TLS2_k127_7012373_9 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000004847 227.0
TLS2_k127_7025532_0 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009831 424.0
TLS2_k127_7025532_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 372.0
TLS2_k127_7025532_10 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K09459 - 4.1.1.82 0.00000278 58.0
TLS2_k127_7025532_2 Aldo Keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009418 284.0
TLS2_k127_7025532_3 Amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000008649 278.0
TLS2_k127_7025532_4 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001513 246.0
TLS2_k127_7025532_5 Enoyl-CoA hydratase/isomerase K01661,K07536 - 4.1.3.36 0.000000000000000000000000000000000000000000000000000002345 203.0
TLS2_k127_7025532_6 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000002777 166.0
TLS2_k127_7025532_7 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.00000000000000000000000000007085 131.0
TLS2_k127_7025532_8 Oxidoreductase family, C-terminal alpha/beta domain K19181 - 1.1.1.292 0.000000000000000000000003356 119.0
TLS2_k127_7025532_9 Non-essential cell division protein that could be required for efficient cell constriction - - - 0.000001177 61.0
TLS2_k127_7026798_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000111 215.0
TLS2_k127_7026798_1 UTRA K03710 - - 0.00000000000000000000000000000000000000000000000000000001503 206.0
TLS2_k127_7026798_2 Amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000000000000000000000000000000006906 203.0
TLS2_k127_7026798_3 Cupin domain - - - 0.0000000000000000000000000000006682 129.0
TLS2_k127_7026798_4 Cupin domain - - - 0.00001866 48.0
TLS2_k127_7028707_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.364e-226 715.0
TLS2_k127_7028707_1 DSHCT K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 631.0
TLS2_k127_7028707_10 Belongs to the pseudouridine synthase RsuA family K06178,K06183 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000004593 235.0
TLS2_k127_7028707_11 Cytidylate kinase K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000007027 196.0
TLS2_k127_7028707_12 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000003264 177.0
TLS2_k127_7028707_13 PFAM Rhomboid family protein - - - 0.0000000000000000000000000000000000000000000006491 180.0
TLS2_k127_7028707_14 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000002403 171.0
TLS2_k127_7028707_15 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000004166 166.0
TLS2_k127_7028707_16 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000001247 162.0
TLS2_k127_7028707_17 Haloacid dehalogenase-like hydrolase K01101 - 3.1.3.41 0.00000000000000000000000000000000000001013 161.0
TLS2_k127_7028707_18 Hydrolase, NUDIX family K01515 - 3.6.1.13 0.0000000000000000000000000000000002367 142.0
TLS2_k127_7028707_19 Redoxin - - - 0.000000000000000000000000000000009904 136.0
TLS2_k127_7028707_2 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 440.0
TLS2_k127_7028707_20 NUDIX domain - - - 0.000000000000000000000000000000771 126.0
TLS2_k127_7028707_21 Belongs to the DsbB family K03611 - - 0.000000000000000000000000323 115.0
TLS2_k127_7028707_22 Diacylglycerol kinase catalytic domain - - - 0.000000000000000000000001982 115.0
TLS2_k127_7028707_24 Transcriptional regulator, TraR DksA family K06204 - - 0.000000000000000888 81.0
TLS2_k127_7028707_25 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.000000101 61.0
TLS2_k127_7028707_26 Acetyltransferase (GNAT) family - - - 0.000000273 58.0
TLS2_k127_7028707_27 PFAM Metal-dependent phosphohydrolase, HD - - - 0.00001763 53.0
TLS2_k127_7028707_28 Domain of unknown function (DUF4193) - - - 0.0001834 50.0
TLS2_k127_7028707_3 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009477 360.0
TLS2_k127_7028707_4 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008652 364.0
TLS2_k127_7028707_5 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006933 339.0
TLS2_k127_7028707_6 May be involved in recombinational repair of damaged DNA K03631 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002952 294.0
TLS2_k127_7028707_7 VanW like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002443 288.0
TLS2_k127_7028707_8 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000008867 255.0
TLS2_k127_7028707_9 FtsJ-like methyltransferase K06442 GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000007524 250.0
TLS2_k127_706127_0 Acyl-CoA dehydrogenase, middle domain - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000782 514.0
TLS2_k127_706127_1 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 484.0
TLS2_k127_706127_10 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000002229 239.0
TLS2_k127_706127_11 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000001366 219.0
TLS2_k127_706127_12 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000000002634 202.0
TLS2_k127_706127_13 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000000000002661 199.0
TLS2_k127_706127_14 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000002722 193.0
TLS2_k127_706127_15 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.0000000000000000000000000000000000000000000000002222 195.0
TLS2_k127_706127_16 transcriptional regulator K03719 - - 0.0000000000000000000000000000000000000000000000005961 180.0
TLS2_k127_706127_17 COGs COG3288 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.00000000000000000000000000002453 133.0
TLS2_k127_706127_18 TIGRFAM TrpR like protein, YerC YecD - - - 0.0000000000000000002397 97.0
TLS2_k127_706127_19 serine-type peptidase activity K08676 - - 0.00000000009996 62.0
TLS2_k127_706127_2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005249 449.0
TLS2_k127_706127_20 Sigma-70 region 2 K03088 - - 0.000000002003 66.0
TLS2_k127_706127_21 COG0531 Amino acid transporters - - - 0.000001044 60.0
TLS2_k127_706127_22 CBS domain K04767,K07168,K07182 - - 0.0007022 51.0
TLS2_k127_706127_3 DNA polymerase III, epsilon subunit K02342 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004994 413.0
TLS2_k127_706127_4 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013,K15509 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 351.0
TLS2_k127_706127_5 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 312.0
TLS2_k127_706127_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 314.0
TLS2_k127_706127_7 COG0464 ATPases of the AAA class K13525 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 311.0
TLS2_k127_706127_8 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008265 284.0
TLS2_k127_706127_9 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000005258 241.0
TLS2_k127_7113146_0 Flavin containing amine oxidoreductase - - - 5.384e-248 795.0
TLS2_k127_7113146_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006093 594.0
TLS2_k127_7113146_10 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 412.0
TLS2_k127_7113146_11 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 364.0
TLS2_k127_7113146_12 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004126 366.0
TLS2_k127_7113146_13 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 359.0
TLS2_k127_7113146_14 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 344.0
TLS2_k127_7113146_15 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 326.0
TLS2_k127_7113146_16 ABC transporter (Permease) K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006086 313.0
TLS2_k127_7113146_17 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 289.0
TLS2_k127_7113146_18 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 304.0
TLS2_k127_7113146_19 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001009 289.0
TLS2_k127_7113146_2 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 573.0
TLS2_k127_7113146_20 ABC transporter K01990,K13926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001362 261.0
TLS2_k127_7113146_21 ornithine cyclodeaminase K01750,K19244 - 1.4.1.1,4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000002362 253.0
TLS2_k127_7113146_22 Belongs to the DapA family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000001212 245.0
TLS2_k127_7113146_23 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000001168 241.0
TLS2_k127_7113146_24 Isochorismatase family K08281 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000001586 224.0
TLS2_k127_7113146_25 Belongs to the serpin family K13963 - - 0.000000000000000000000000000000000000000000000000005238 197.0
TLS2_k127_7113146_26 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000149 191.0
TLS2_k127_7113146_27 - - - - 0.00000000000000000000000000000000000000002599 155.0
TLS2_k127_7113146_28 BetI-type transcriptional repressor, C-terminal - - - 0.00000000000000000000000000000000000004174 154.0
TLS2_k127_7113146_29 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000001129 139.0
TLS2_k127_7113146_3 Aldehyde dehydrogenase family K00138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 515.0
TLS2_k127_7113146_30 PspC domain - - - 0.0000000000000000000000000000000001659 149.0
TLS2_k127_7113146_31 Toxic component of a toxin-antitoxin (TA) module. An RNase - GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.0000000000000000000000000000003123 127.0
TLS2_k127_7113146_32 - - - - 0.0000000000000000000000000000005957 137.0
TLS2_k127_7113146_33 PspC domain - - - 0.000000000000000000000000000001031 139.0
TLS2_k127_7113146_34 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000006873 115.0
TLS2_k127_7113146_35 DNA binding domain with preference for A/T rich regions K18958 GO:0001101,GO:0008150,GO:0010033,GO:0033993,GO:0042221,GO:0046677,GO:0050896,GO:0070542,GO:1901700 - 0.0000000000000001594 84.0
TLS2_k127_7113146_36 Belongs to the UPF0337 (CsbD) family - - - 0.0000000000000168 76.0
TLS2_k127_7113146_37 Cell wall-active antibiotics response 4TMS YvqF - - - 0.00000000006536 71.0
TLS2_k127_7113146_38 positive regulation of growth - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.00000000108 63.0
TLS2_k127_7113146_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 504.0
TLS2_k127_7113146_5 Glycine cleavage T-protein C-terminal barrel domain K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 488.0
TLS2_k127_7113146_6 Ring hydroxylating alpha subunit (catalytic domain) K00479 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006692 430.0
TLS2_k127_7113146_7 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 425.0
TLS2_k127_7113146_8 Peptidase family S58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 419.0
TLS2_k127_7113146_9 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 432.0
TLS2_k127_7247937_0 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 491.0
TLS2_k127_7247937_1 Spermidine synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004951 406.0
TLS2_k127_7247937_10 Chitinase class I K03791 - - 0.000000000000000000000000003188 125.0
TLS2_k127_7247937_11 poly(R)-hydroxyalkanoic acid synthase subunit PhaC K03821 - - 0.0000002574 57.0
TLS2_k127_7247937_12 transcriptional regulator - - - 0.0007869 50.0
TLS2_k127_7247937_2 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 367.0
TLS2_k127_7247937_3 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 312.0
TLS2_k127_7247937_4 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 299.0
TLS2_k127_7247937_5 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006224 290.0
TLS2_k127_7247937_6 COG2087 Adenosyl cobinamide kinase adenosyl cobinamide phosphate guanylyltransferase K02231 - 2.7.1.156,2.7.7.62 0.0000000000000000000000000000000000000000000001578 174.0
TLS2_k127_7247937_7 phosphoglycerate mutase family - - - 0.000000000000000000000000000000000000000007312 171.0
TLS2_k127_7247937_8 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000003432 141.0
TLS2_k127_7247937_9 phosphoglycerate mutase family - - - 0.0000000000000000000000000001631 122.0
TLS2_k127_7333386_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 1.69e-242 757.0
TLS2_k127_7333386_1 Beta propeller domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 614.0
TLS2_k127_7333386_10 - - - - 0.000000000126 74.0
TLS2_k127_7333386_2 ribosomal rna small subunit methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007445 394.0
TLS2_k127_7333386_3 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 331.0
TLS2_k127_7333386_4 Cytidine monophosphokinase K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000001296 242.0
TLS2_k127_7333386_5 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.00000000000000000000000000000000000000000000000000000004144 209.0
TLS2_k127_7333386_6 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000874 185.0
TLS2_k127_7333386_7 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000007004 181.0
TLS2_k127_7333386_8 Phage shock protein A (IM30), suppresses sigma54-dependent transcription K03969 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044464,GO:0071944 - 0.0000000000000000000000000000004256 132.0
TLS2_k127_7333386_9 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000006492 109.0
TLS2_k127_7377727_0 Belongs to the peptidase S8 family - - - 3.545e-247 801.0
TLS2_k127_7377727_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 1.695e-227 716.0
TLS2_k127_7377727_10 Belongs to the UPF0234 family K09767 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000001859 167.0
TLS2_k127_7377727_11 acr, cog1565 - - - 0.0000000000000000000000000000000000000000001838 173.0
TLS2_k127_7377727_12 Glycoprotease family K14742 GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000192 151.0
TLS2_k127_7377727_13 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000002997 133.0
TLS2_k127_7377727_14 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000000000000000000000001264 140.0
TLS2_k127_7377727_15 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06925 GO:0008150,GO:0040007 - 0.0000000000000000000000000029 121.0
TLS2_k127_7377727_16 Sigma-70 region 2 K03088 - - 0.00000000000000000000000003145 115.0
TLS2_k127_7377727_17 - - - - 0.0000000000000000000004411 102.0
TLS2_k127_7377727_18 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000001038 81.0
TLS2_k127_7377727_19 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.000000000000002301 89.0
TLS2_k127_7377727_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 398.0
TLS2_k127_7377727_20 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000001258 62.0
TLS2_k127_7377727_3 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005056 329.0
TLS2_k127_7377727_4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000321 334.0
TLS2_k127_7377727_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 327.0
TLS2_k127_7377727_6 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008927 265.0
TLS2_k127_7377727_7 PFAM peptidase S58 DmpA - - - 0.0000000000000000000000000000000000000000000000000000000000000000003457 239.0
TLS2_k127_7377727_8 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.000000000000000000000000000000000000000000000000000000000009431 226.0
TLS2_k127_7377727_9 Uracil-DNA glycosylase, family 4 K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000006049 204.0
TLS2_k127_7380806_0 COG0475 Kef-type K transport systems, membrane components - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 449.0
TLS2_k127_7380806_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 443.0
TLS2_k127_7380806_2 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 354.0
TLS2_k127_7380806_3 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 323.0
TLS2_k127_7380806_4 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 318.0
TLS2_k127_7380806_5 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000000002798 215.0
TLS2_k127_7380806_6 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000005598 188.0
TLS2_k127_7380806_7 MaoC like domain - - - 0.0000000000000000000000000000000000000000000002822 171.0
TLS2_k127_7459799_0 Glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1250.0
TLS2_k127_7459799_1 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 3.934e-286 903.0
TLS2_k127_7459799_10 COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01911 - 6.2.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000002817 270.0
TLS2_k127_7459799_11 Belongs to the MenA family. Type 1 subfamily K02548 GO:0003674,GO:0003824,GO:0004659,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 0.00000000000000000000000000000000000000000000000000000000000000001896 239.0
TLS2_k127_7459799_12 COG1131 ABC-type multidrug transport system, ATPase component - - - 0.0000000000000000000000000000000000000000000000000000000000002783 215.0
TLS2_k127_7459799_13 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000008741 218.0
TLS2_k127_7459799_14 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000002777 185.0
TLS2_k127_7459799_15 Peptidase S16, lon domain protein K01338,K07157 - 3.4.21.53 0.000000000000000000000000000000000007412 150.0
TLS2_k127_7459799_16 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000001451 140.0
TLS2_k127_7459799_17 stage II sporulation protein K06381 - - 0.0000000000000000000000000000000174 146.0
TLS2_k127_7459799_18 RF-1 domain K15034 - - 0.000000000000000000000000001332 125.0
TLS2_k127_7459799_19 NifU-like domain - - - 0.000000000000000000004283 96.0
TLS2_k127_7459799_2 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 8.157e-223 706.0
TLS2_k127_7459799_20 PFAM CBS domain - - - 0.00000000000000000007613 97.0
TLS2_k127_7459799_21 Universal stress protein - - - 0.000000000000000432 89.0
TLS2_k127_7459799_23 Peptidase family M23 - - - 0.00000000000001116 83.0
TLS2_k127_7459799_24 - - - - 0.00000000008281 71.0
TLS2_k127_7459799_3 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004149 497.0
TLS2_k127_7459799_4 Belongs to the EPSP synthase family. MurA subfamily K00790 GO:0008150,GO:0040007 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 422.0
TLS2_k127_7459799_5 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 394.0
TLS2_k127_7459799_6 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 379.0
TLS2_k127_7459799_7 Dipeptidyl aminopeptidase acylaminoacyl peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000824 333.0
TLS2_k127_7459799_8 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 291.0
TLS2_k127_7459799_9 ArgK protein K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007425 282.0
TLS2_k127_760823_0 TIGRFAM phenylacetic acid degradation protein paaN K02618 - 1.2.1.91,3.3.2.12 4.735e-261 827.0
TLS2_k127_760823_1 Acyclic terpene utilisation family protein AtuA - - - 4.897e-220 702.0
TLS2_k127_760823_10 type II secretion system protein E K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000336 322.0
TLS2_k127_760823_11 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005824 312.0
TLS2_k127_760823_12 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004077 290.0
TLS2_k127_760823_13 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008463 285.0
TLS2_k127_760823_14 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000001422 278.0
TLS2_k127_760823_15 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0003674,GO:0003824,GO:0016740,GO:0016765,GO:0033850 2.5.1.31,2.5.1.68 0.0000000000000000000000000000000000000000000000000000000000000000000001448 250.0
TLS2_k127_760823_16 alpha-ribazole phosphatase activity K02226,K15634 - 3.1.3.73,5.4.2.12 0.0000000000000000000000000000000000000000000000000008251 193.0
TLS2_k127_760823_17 Uncharacterised protein, DegV family COG1307 - - - 0.0000000000000000000000000000000000000000003927 174.0
TLS2_k127_760823_18 Haemolysin-III related K11068 - - 0.00000000000000000000000000000000000006882 153.0
TLS2_k127_760823_19 PFAM Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000002833 146.0
TLS2_k127_760823_2 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006959 587.0
TLS2_k127_760823_20 translation release factor activity - - - 0.00000000000000000000000000000001049 141.0
TLS2_k127_760823_21 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000185 119.0
TLS2_k127_760823_22 - - - - 0.000000000000000000001483 109.0
TLS2_k127_760823_23 Regulates arginine biosynthesis genes K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000008263 104.0
TLS2_k127_760823_24 FR47-like protein - - - 0.0000000000000000003779 96.0
TLS2_k127_760823_25 Histidine kinase-like ATPase domain - - - 0.0000000002893 66.0
TLS2_k127_760823_26 regulatory protein - - - 0.00000001489 63.0
TLS2_k127_760823_27 antisigma factor binding K05946 - 2.4.1.187 0.0000008881 55.0
TLS2_k127_760823_3 Arginosuccinate synthase K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006772 587.0
TLS2_k127_760823_4 Probable RNA and SrmB- binding site of polymerase A K00970,K00974 - 2.7.7.19,2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 490.0
TLS2_k127_760823_5 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 410.0
TLS2_k127_760823_6 Argininosuccinate lyase C-terminal K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 379.0
TLS2_k127_760823_7 hydrolase activity, acting on ester bonds K01563 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009410,GO:0009987,GO:0016020,GO:0016787,GO:0016824,GO:0018786,GO:0019120,GO:0030312,GO:0042178,GO:0042197,GO:0042206,GO:0042221,GO:0044237,GO:0044248,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071466,GO:0071704,GO:0071944,GO:1901575 3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 368.0
TLS2_k127_760823_8 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005237 371.0
TLS2_k127_760823_9 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003445 324.0
TLS2_k127_769096_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.666e-271 855.0
TLS2_k127_769096_1 Heat shock 70 kDa protein K04043 - - 1.943e-268 840.0
TLS2_k127_769096_10 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 462.0
TLS2_k127_769096_11 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 473.0
TLS2_k127_769096_12 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 431.0
TLS2_k127_769096_13 Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 449.0
TLS2_k127_769096_14 Oligopeptide/dipeptide transporter, C-terminal region K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005858 433.0
TLS2_k127_769096_15 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 421.0
TLS2_k127_769096_16 helicase superfamily c-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005847 415.0
TLS2_k127_769096_17 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 399.0
TLS2_k127_769096_18 Putative glycosyl hydrolase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 404.0
TLS2_k127_769096_19 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008827 379.0
TLS2_k127_769096_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.716e-220 694.0
TLS2_k127_769096_20 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 367.0
TLS2_k127_769096_22 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 311.0
TLS2_k127_769096_23 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000008416 251.0
TLS2_k127_769096_24 haloacid dehalogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003984 268.0
TLS2_k127_769096_25 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001126 236.0
TLS2_k127_769096_26 A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics - - - 0.000000000000000000000000000000000000000000000000000000000000000001203 246.0
TLS2_k127_769096_27 sequence-specific DNA binding K00567,K13529,K15051 - 2.1.1.63,3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000001114 235.0
TLS2_k127_769096_28 major pilin protein fima - - - 0.00000000000000000000000000000000000000000000000000000000000000687 239.0
TLS2_k127_769096_29 - - - - 0.0000000000000000000000000000000000000000000000000000000002599 207.0
TLS2_k127_769096_3 FtsK/SpoIIIE family K03466 GO:0002790,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009405,GO:0009605,GO:0009607,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0020012,GO:0030312,GO:0030682,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0040007,GO:0042783,GO:0042886,GO:0043207,GO:0044110,GO:0044116,GO:0044117,GO:0044315,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0075136 - 9.999e-211 703.0
TLS2_k127_769096_30 PFAM Methionine sulfoxide reductase B K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000001726 197.0
TLS2_k127_769096_31 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000004042 199.0
TLS2_k127_769096_32 MerR, DNA binding K13639 - - 0.00000000000000000000000000000000000000000000000000001582 194.0
TLS2_k127_769096_33 CHAD - - - 0.000000000000000000000000000000000000000000000008674 190.0
TLS2_k127_769096_34 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000007148 173.0
TLS2_k127_769096_35 Pfam NUDIX - - - 0.000000000000000000000000000000000000000002774 165.0
TLS2_k127_769096_36 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000001659 152.0
TLS2_k127_769096_37 PAS fold - - - 0.0000000000000000000000000000000000262 156.0
TLS2_k127_769096_38 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000004911 151.0
TLS2_k127_769096_39 - - - - 0.0000000000000000000000000000000001664 138.0
TLS2_k127_769096_4 Extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 584.0
TLS2_k127_769096_40 Thioesterase - - - 0.000000000000000000000000000000008313 148.0
TLS2_k127_769096_41 Protein of unknown function (DUF421) - - - 0.00000000000000000000000000000003981 130.0
TLS2_k127_769096_42 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000005482 131.0
TLS2_k127_769096_43 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000000000000005309 130.0
TLS2_k127_769096_44 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000001062 120.0
TLS2_k127_769096_45 regulatory protein, arsR - - - 0.000000000000000000000000006171 118.0
TLS2_k127_769096_46 transcriptional regulator - - - 0.00000000000000000000003179 109.0
TLS2_k127_769096_47 AzlC protein - - - 0.00000000000000000000003323 115.0
TLS2_k127_769096_48 - - - - 0.00000000000000000002016 98.0
TLS2_k127_769096_49 Acetyltransferase (GNAT) domain - - - 0.00000000000000000286 91.0
TLS2_k127_769096_5 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 608.0
TLS2_k127_769096_50 Glycosyl hydrolases family 25 - - - 0.000000000000002651 89.0
TLS2_k127_769096_51 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000002235 73.0
TLS2_k127_769096_52 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000005635 73.0
TLS2_k127_769096_53 - - - - 0.000000002064 69.0
TLS2_k127_769096_54 ADP-ribosylglycohydrolase - - - 0.000000008304 68.0
TLS2_k127_769096_55 Branched-chain amino acid transport protein (AzlD) - - - 0.000003644 54.0
TLS2_k127_769096_56 Belongs to the WXG100 family K14956 - - 0.00008545 51.0
TLS2_k127_769096_6 acyl-CoA dehydrogenase K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 569.0
TLS2_k127_769096_7 N-4 methylation of cytosine K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 500.0
TLS2_k127_769096_8 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 469.0
TLS2_k127_769096_9 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008095 465.0
TLS2_k127_930653_0 Evidence 2b Function of strongly homologous gene K05343 - 3.2.1.1,5.4.99.16 1.354e-223 706.0
TLS2_k127_930653_1 Acyl-CoA oxidase K00232 - 1.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005912 581.0
TLS2_k127_930653_10 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005318 441.0
TLS2_k127_930653_11 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 419.0
TLS2_k127_930653_12 Dehydrogenase E1 component K21416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 396.0
TLS2_k127_930653_13 Transcriptional regulator, LuxR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 404.0
TLS2_k127_930653_14 binding-protein-dependent transport systems inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 381.0
TLS2_k127_930653_15 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 367.0
TLS2_k127_930653_16 Penicillin binding protein transpeptidase domain K05364 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 370.0
TLS2_k127_930653_17 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 334.0
TLS2_k127_930653_18 amino acid aldolase or racemase K20757 - 4.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 346.0
TLS2_k127_930653_19 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 336.0
TLS2_k127_930653_2 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 560.0
TLS2_k127_930653_20 Cell cycle protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 331.0
TLS2_k127_930653_21 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 318.0
TLS2_k127_930653_22 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 312.0
TLS2_k127_930653_23 COG3221 ABC-type phosphate phosphonate transport system, periplasmic component K02044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005356 290.0
TLS2_k127_930653_24 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003693 304.0
TLS2_k127_930653_25 PFAM Peptidase family M20 M25 M40 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006257 291.0
TLS2_k127_930653_26 Domain of unknown function (DUF1731) K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006588 282.0
TLS2_k127_930653_27 mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003472 280.0
TLS2_k127_930653_28 Domain of unknown function (DUF3524) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001028 275.0
TLS2_k127_930653_29 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000127 274.0
TLS2_k127_930653_3 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0016874,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 554.0
TLS2_k127_930653_30 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001959 269.0
TLS2_k127_930653_31 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002918 253.0
TLS2_k127_930653_32 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001276 266.0
TLS2_k127_930653_33 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000000000000000000001346 229.0
TLS2_k127_930653_34 endonuclease III K03575 - - 0.000000000000000000000000000000000000000000000000000000000000199 242.0
TLS2_k127_930653_35 phosphatase activity K05967 - - 0.0000000000000000000000000000000000000000000000000000000000004089 219.0
TLS2_k127_930653_36 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.0000000000000000000000000000000000000000000000000000000000006173 222.0
TLS2_k127_930653_37 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000131 231.0
TLS2_k127_930653_38 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000007389 227.0
TLS2_k127_930653_39 PFAM TspO MBR family protein K05770 - - 0.000000000000000000000000000000000000000000000000000000002609 203.0
TLS2_k127_930653_4 PFAM Glycosyl hydrolase family 1 K01223,K05350 - 3.2.1.21,3.2.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 527.0
TLS2_k127_930653_40 Periplasmic binding protein LacI transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000001176 224.0
TLS2_k127_930653_41 Beta-lactamase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000001737 221.0
TLS2_k127_930653_42 2OG-Fe(II) oxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000001372 203.0
TLS2_k127_930653_43 Sporulation and spore germination - - - 0.0000000000000000000000000000000000000000000000000002672 198.0
TLS2_k127_930653_44 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K11991 - 3.5.4.1,3.5.4.33 0.000000000000000000000000000000000000000000000000002339 187.0
TLS2_k127_930653_45 Sigma factor PP2C-like phosphatases K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000006764 195.0
TLS2_k127_930653_46 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.000000000000000000000000000000000000000000000002493 182.0
TLS2_k127_930653_47 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000002998 181.0
TLS2_k127_930653_48 menaquinone-dependent protoporphyrinogen oxidase activity K00230 - 1.3.5.3 0.00000000000000000000000000000000000000000000003576 181.0
TLS2_k127_930653_49 protein phosphatase 2C domain protein - - - 0.00000000000000000000000000000000000000000000003855 190.0
TLS2_k127_930653_5 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897,K01904 - 6.2.1.12,6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005389 531.0
TLS2_k127_930653_50 e3 binding domain K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000002661 180.0
TLS2_k127_930653_51 ATP-NAD kinase - - - 0.000000000000000000000000000000000000000000007336 177.0
TLS2_k127_930653_52 PFAM OsmC-like protein K04063 - - 0.00000000000000000000000000000000000000000006217 169.0
TLS2_k127_930653_53 ABC transporter K02042 - - 0.0000000000000000000000000000000000000000002033 179.0
TLS2_k127_930653_54 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000002428 168.0
TLS2_k127_930653_55 Anthranilate synthase component I, N terminal region K01657,K01665,K03342,K13950 - 2.6.1.85,4.1.3.27,4.1.3.38 0.0000000000000000000000000000000000000007663 151.0
TLS2_k127_930653_56 metal-dependent hydrolase K07043 - - 0.000000000000000000000000000000000000007809 151.0
TLS2_k127_930653_57 Histidine kinase - - - 0.0000000000000000000000000000000000000082 160.0
TLS2_k127_930653_58 Diacylglycerol kinase catalytic domain (presumed) - - - 0.0000000000000000000000000000000000000188 156.0
TLS2_k127_930653_59 PFAM DsrC family protein K11179 - - 0.0000000000000000000000000000000000003576 149.0
TLS2_k127_930653_6 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 484.0
TLS2_k127_930653_60 ABC transporter K02042 - - 0.000000000000000000000000000000000001065 157.0
TLS2_k127_930653_61 - - - - 0.000000000000000000000000000000000002301 148.0
TLS2_k127_930653_62 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000002287 123.0
TLS2_k127_930653_63 Domain of unknown function (DUF4870) K09940 - - 0.00000000000000000000000002473 115.0
TLS2_k127_930653_64 - - - - 0.00000000000000000000001572 108.0
TLS2_k127_930653_65 SnoaL-like domain K06893 - - 0.0000000000000000000008259 100.0
TLS2_k127_930653_66 - K01992 - - 0.00000000000000000002079 107.0
TLS2_k127_930653_67 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000002986 95.0
TLS2_k127_930653_68 Forkhead associated domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.000000000000000001085 91.0
TLS2_k127_930653_69 (FHA) domain - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.000000000000000002153 94.0
TLS2_k127_930653_7 Transketolase, central region K11381,K21417 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 492.0
TLS2_k127_930653_70 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000005499 89.0
TLS2_k127_930653_71 CHASE2 K01768 - 4.6.1.1 0.0000000000000006154 87.0
TLS2_k127_930653_72 SEC-C motif - - - 0.00000000000001951 81.0
TLS2_k127_930653_73 FCD - - - 0.00000000000004258 81.0
TLS2_k127_930653_74 His Kinase A (phosphoacceptor) domain - - - 0.00000000000004623 85.0
TLS2_k127_930653_75 - - - - 0.000000000000742 72.0
TLS2_k127_930653_76 Sigma-70, region 4 K03088 - - 0.0000000009111 72.0
TLS2_k127_930653_77 Domain of unknown function (DUF4190) - - - 0.00000006887 65.0
TLS2_k127_930653_78 Phage integrase, N-terminal SAM-like domain - - - 0.000001186 55.0
TLS2_k127_930653_79 ERCC4 domain protein - - - 0.000001469 53.0
TLS2_k127_930653_8 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 473.0
TLS2_k127_930653_80 SEC-C motif - - - 0.00001508 51.0
TLS2_k127_930653_82 Peptidase family M48 - - - 0.0001781 50.0
TLS2_k127_930653_84 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.0007466 49.0
TLS2_k127_930653_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 449.0