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Overview

ID MAG03992
Name TLS2_bin.25
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Chloroflexota
Class Limnocylindria
Order QHBO01
Family QHBO01
Genus JAPSGM01
Species
Assembly information
Completeness (%) 56.17
Contamination (%) 0.03
GC content (%) 72.0
N50 (bp) 12,313
Genome size (bp) 1,364,492

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1273

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1023456_0 Belongs to the transketolase family K00615 - 2.2.1.1 7.566e-258 819.0
TLS2_k127_1023456_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005317 467.0
TLS2_k127_1023456_2 PRMT5 arginine-N-methyltransferase K11434 - 2.1.1.319 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 365.0
TLS2_k127_1023456_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 357.0
TLS2_k127_1023456_4 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000378 327.0
TLS2_k127_1023456_5 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 329.0
TLS2_k127_1023456_6 Probable zinc-ribbon domain - - - 0.00000000000000000000000000000006052 135.0
TLS2_k127_1023456_8 Isochorismatase family K08281 - 3.5.1.19 0.0002543 44.0
TLS2_k127_1036904_0 PFAM homogentisate 12-dioxygenase K00451 - 1.13.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 515.0
TLS2_k127_1036904_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 458.0
TLS2_k127_1036904_10 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004866 241.0
TLS2_k127_1036904_11 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000007883 201.0
TLS2_k127_1036904_12 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000002531 196.0
TLS2_k127_1036904_13 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000000000000000000000000000000001258 190.0
TLS2_k127_1036904_14 helix_turn_helix, cAMP Regulatory protein K01420,K10914,K21561,K21564 - - 0.00000000000000000000000000000000000000009464 161.0
TLS2_k127_1036904_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.000000000000000000000000000000000000003207 150.0
TLS2_k127_1036904_16 - - - - 0.00000000000000000000000000000000000005513 153.0
TLS2_k127_1036904_17 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000000004854 129.0
TLS2_k127_1036904_18 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.000000000000000000000000008025 123.0
TLS2_k127_1036904_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007646 397.0
TLS2_k127_1036904_20 PFAM Methyltransferase type K15256 - - 0.00000000000000000000003614 112.0
TLS2_k127_1036904_21 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.00000000000000000000504 98.0
TLS2_k127_1036904_22 Bacterial protein of unknown function (DUF885) - - - 0.000000000000002524 83.0
TLS2_k127_1036904_23 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000006629 76.0
TLS2_k127_1036904_25 Major Facilitator Superfamily - - - 0.000008257 59.0
TLS2_k127_1036904_26 - - - - 0.0006157 48.0
TLS2_k127_1036904_3 Enoyl- acyl-carrier-protein reductase NADH K00208,K11611 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030312,GO:0030497,GO:0031406,GO:0032787,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005952 304.0
TLS2_k127_1036904_4 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004152 320.0
TLS2_k127_1036904_5 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009259 294.0
TLS2_k127_1036904_6 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 296.0
TLS2_k127_1036904_7 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 299.0
TLS2_k127_1036904_8 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001825 269.0
TLS2_k127_1036904_9 Fumarylacetoacetate (FAA) hydrolase family K16171 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000022 268.0
TLS2_k127_1130201_0 Carbohydrate phosphorylase K00688,K00691 - 2.4.1.1,2.4.1.8 9.469e-201 647.0
TLS2_k127_1130201_1 TIGRFAM cysteine desulfurase family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 466.0
TLS2_k127_1130201_2 SMART Peptidoglycan-binding LysM - - - 0.00000000000000000000000000143 128.0
TLS2_k127_1130201_3 Belongs to the UPF0761 family K07058 - - 0.0007044 46.0
TLS2_k127_1179913_0 helicase superfamily c-terminal domain K06877 - - 7.939e-275 867.0
TLS2_k127_1179913_1 VIT family - - - 0.00000000000000000000000000000000000000000000000533 187.0
TLS2_k127_1179913_2 Transmembrane secretion effector - - - 0.000000000000000000007278 96.0
TLS2_k127_1179913_3 RNase_H superfamily K07502 - - 0.0000000000006985 80.0
TLS2_k127_1179913_4 PFAM Septum formation initiator K05589,K13052 - - 0.00000107 57.0
TLS2_k127_1180575_0 TIGRFAM LAO AO transport system ATPase K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003142 270.0
TLS2_k127_1180575_1 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000002987 257.0
TLS2_k127_1180575_2 methylmalonyl-CoA mutase C-terminal K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000001418 185.0
TLS2_k127_1180575_3 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000000005071 118.0
TLS2_k127_1180575_4 NERD domain protein - - - 0.00001035 55.0
TLS2_k127_11818_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 3.618e-278 878.0
TLS2_k127_11818_1 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 1.223e-250 788.0
TLS2_k127_11818_10 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 411.0
TLS2_k127_11818_11 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 419.0
TLS2_k127_11818_12 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 372.0
TLS2_k127_11818_13 alcohol dehydrogenase K00008,K08322 - 1.1.1.14,1.1.1.380 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 340.0
TLS2_k127_11818_14 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005106 327.0
TLS2_k127_11818_15 branched-chain amino acid transmembrane transporter activity K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 319.0
TLS2_k127_11818_16 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 312.0
TLS2_k127_11818_17 Short-chain dehydrogenase reductase sdr K00046 - 1.1.1.69 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 307.0
TLS2_k127_11818_18 PFAM extracellular solute-binding protein family 1 K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 317.0
TLS2_k127_11818_19 Binding-protein-dependent transport system inner membrane component K11070 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002648 291.0
TLS2_k127_11818_2 ABC-type branched-chain amino acid transport systems, periplasmic component K01999,K07407 - 3.2.1.22 2.309e-209 665.0
TLS2_k127_11818_21 Transcriptional regulator K22293 - - 0.000000000000000000000000000000000000000000000000000000000000001641 227.0
TLS2_k127_11818_22 alcohol dehydrogenase K00008,K08322 - 1.1.1.14,1.1.1.380 0.00000000000000000000000000000000000000000000000000000000000001234 221.0
TLS2_k127_11818_23 regulatory protein - - - 0.000000000000000000000000000000000000000000000000000000001448 220.0
TLS2_k127_11818_24 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000006549 216.0
TLS2_k127_11818_25 Psort location Cytoplasmic, score K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000007574 184.0
TLS2_k127_11818_26 spore germination - - - 0.00000000000000000000000000000000005755 146.0
TLS2_k127_11818_27 PFAM flavin reductase domain protein FMN-binding K21185 - - 0.0000000000000000000000000000009344 132.0
TLS2_k127_11818_28 Response regulator receiver domain protein K07658 - - 0.00000000000008796 77.0
TLS2_k127_11818_29 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.0000000009741 60.0
TLS2_k127_11818_3 von Willebrand factor (vWF) type A domain - - - 1.785e-199 642.0
TLS2_k127_11818_4 L-phenylalanine transmembrane transporter activity K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 487.0
TLS2_k127_11818_5 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003457 510.0
TLS2_k127_11818_6 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003447 450.0
TLS2_k127_11818_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 442.0
TLS2_k127_11818_8 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K05555 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003679 428.0
TLS2_k127_11818_9 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 431.0
TLS2_k127_1183895_0 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 7.4e-323 1005.0
TLS2_k127_1183895_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 450.0
TLS2_k127_1183895_2 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009075 308.0
TLS2_k127_1183895_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 293.0
TLS2_k127_1183895_4 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002181 274.0
TLS2_k127_1183895_5 cAMP-dependent protein kinase regulatory subunit K04739 GO:0000166,GO:0000228,GO:0000785,GO:0000790,GO:0001932,GO:0001933,GO:0002831,GO:0002832,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005886,GO:0005952,GO:0006469,GO:0006950,GO:0007154,GO:0008104,GO:0008150,GO:0008277,GO:0008603,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0010563,GO:0010570,GO:0010605,GO:0010646,GO:0010648,GO:0016020,GO:0017076,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019887,GO:0023051,GO:0023057,GO:0030234,GO:0030291,GO:0030447,GO:0030551,GO:0030552,GO:0030554,GO:0031279,GO:0031281,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031667,GO:0031668,GO:0031669,GO:0031974,GO:0031981,GO:0032101,GO:0032102,GO:0032104,GO:0032105,GO:0032107,GO:0032108,GO:0032268,GO:0032269,GO:0032386,GO:0032388,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032880,GO:0032991,GO:0033036,GO:0033157,GO:0033554,GO:0033673,GO:0034605,GO:0034613,GO:0036094,GO:0036170,GO:0036180,GO:0040007,GO:0040008,GO:0042325,GO:0042326,GO:0042594,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043549,GO:0043949,GO:0043951,GO:0044092,GO:0044093,GO:0044182,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045744,GO:0045761,GO:0045762,GO:0045786,GO:0045859,GO:0045926,GO:0045936,GO:0046578,GO:0046580,GO:0046822,GO:0046824,GO:0046825,GO:0046827,GO:0048518,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051056,GO:0051058,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051246,GO:0051248,GO:0051338,GO:0051339,GO:0051348,GO:0051349,GO:0051445,GO:0051447,GO:0051641,GO:0051716,GO:0051726,GO:0060255,GO:0060258,GO:0060341,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070727,GO:0071496,GO:0071900,GO:0071901,GO:0071944,GO:0080090,GO:0080134,GO:0090087,GO:0090316,GO:0097159,GO:0097271,GO:0097367,GO:0098772,GO:0106070,GO:0106072,GO:0110033,GO:0110034,GO:1900428,GO:1900429,GO:1900434,GO:1900435,GO:1900443,GO:1900444,GO:1901265,GO:1901363,GO:1902531,GO:1902532,GO:1902659,GO:1902660,GO:1903827,GO:1903829,GO:1904951,GO:2000241,GO:2000242,GO:2000479,GO:2000480 - 0.000000000000003221 81.0
TLS2_k127_1183895_6 PhoD-like phosphatase K07004 - - 0.000000001721 70.0
TLS2_k127_1183895_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.000005201 55.0
TLS2_k127_1220142_0 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 3.449e-222 711.0
TLS2_k127_1220142_1 Serine hydrolase involved in the detoxification of formaldehyde - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 471.0
TLS2_k127_1220142_2 abc transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 390.0
TLS2_k127_1220142_3 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006724 387.0
TLS2_k127_1220142_4 glycogen (starch) synthase activity K16148 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 2.4.1.342 0.00000000000000000000000000000000000000000000000000000231 197.0
TLS2_k127_1220142_5 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000001499 162.0
TLS2_k127_1220142_6 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000000000000000000000000000000000000003075 166.0
TLS2_k127_1220142_7 DSBA-like thioredoxin domain - - - 0.00000000000000000000001384 115.0
TLS2_k127_1220142_8 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000001514 63.0
TLS2_k127_1220142_9 cheY-homologous receiver domain - - - 0.00000002577 61.0
TLS2_k127_123420_0 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 3.234e-237 743.0
TLS2_k127_123420_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.454e-203 648.0
TLS2_k127_123420_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 445.0
TLS2_k127_123420_3 Biotin carboxylase C-terminal domain K01941,K01961 - 6.3.4.14,6.3.4.6,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 438.0
TLS2_k127_123420_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004151 394.0
TLS2_k127_123420_5 Cellulose biosynthesis protein BcsQ K03496 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000005661 242.0
TLS2_k127_123420_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.00000000000000000000000000008526 120.0
TLS2_k127_123420_7 Belongs to the ParB family K03497 - - 0.000000000000000000000006818 106.0
TLS2_k127_123420_8 Acetyltransferase (GNAT) domain - - - 0.0000000000000000003989 99.0
TLS2_k127_123420_9 Biotin-requiring enzyme - - - 0.000000000000009683 81.0
TLS2_k127_1235291_0 transferase activity, transferring glycosyl groups K09118,K13693,K21349 - 2.4.1.266,2.4.1.268 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 480.0
TLS2_k127_1235291_1 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity K06215 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 430.0
TLS2_k127_1235291_10 PFAM glycosyl transferase family 39 K00728 - 2.4.1.109 0.00000000000000000000000000000000000000000000000000000000008241 226.0
TLS2_k127_1235291_11 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000003021 213.0
TLS2_k127_1235291_12 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000004187 209.0
TLS2_k127_1235291_13 SMART HNH nuclease - - - 0.0000000000000000000000000000000000000000000000000000007907 199.0
TLS2_k127_1235291_14 YbaK prolyl-tRNA synthetase associated - - - 0.0000000000000000000000000000000000000000000897 165.0
TLS2_k127_1235291_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000001337 163.0
TLS2_k127_1235291_16 His Kinase A (phosphoacceptor) domain K07642 - 2.7.13.3 0.00000000000000000000000000000000000000005851 171.0
TLS2_k127_1235291_17 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000005707 138.0
TLS2_k127_1235291_18 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000005748 138.0
TLS2_k127_1235291_19 transporter K07238,K11021 - - 0.00000000000000000000000004976 125.0
TLS2_k127_1235291_2 Glycosyl transferase, family 2 K21349 - 2.4.1.268 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005117 384.0
TLS2_k127_1235291_20 Cell envelope-like function transcriptional attenuator common domain protein - - - 0.000000000000000000002462 109.0
TLS2_k127_1235291_21 Belongs to the Fur family K03711,K22297 - - 0.00000000000000183 89.0
TLS2_k127_1235291_22 ATP dependent DNA ligase domain K01971 - 6.5.1.1 0.00000000000001141 83.0
TLS2_k127_1235291_23 - - - - 0.000000005152 68.0
TLS2_k127_1235291_3 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 362.0
TLS2_k127_1235291_4 Belongs to the glycerate kinase type-1 family K00865 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 351.0
TLS2_k127_1235291_5 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002908 353.0
TLS2_k127_1235291_6 PolyA polymerase K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008682 328.0
TLS2_k127_1235291_7 PDZ domain (Also known as DHR or GLGF) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005936 254.0
TLS2_k127_1235291_8 PFAM single-stranded nucleic acid binding R3H domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000002455 220.0
TLS2_k127_1235291_9 COG COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms Transcription - - - 0.00000000000000000000000000000000000000000000000000000000000008595 222.0
TLS2_k127_1335069_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008637 422.0
TLS2_k127_1335069_1 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000001561 270.0
TLS2_k127_1335069_10 PFAM Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000000000000000000001247 108.0
TLS2_k127_1335069_11 Belongs to the Fur family K03711,K09825 - - 0.000000000000000000000002111 108.0
TLS2_k127_1335069_13 - - - - 0.00000171 59.0
TLS2_k127_1335069_14 membrane - - - 0.00001226 51.0
TLS2_k127_1335069_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006739 275.0
TLS2_k127_1335069_3 arsR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001015 265.0
TLS2_k127_1335069_4 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001607 280.0
TLS2_k127_1335069_5 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001428 254.0
TLS2_k127_1335069_6 High-affinity nickel-transport protein K07241 - - 0.000000000000000000000000000000000000000000000000000000000000000002427 235.0
TLS2_k127_1335069_7 serine-type endopeptidase activity K04771 GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000003023 241.0
TLS2_k127_1335069_8 regulation of RNA biosynthetic process - - - 0.0000000000000000000000000002261 125.0
TLS2_k127_1394499_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 498.0
TLS2_k127_1394499_1 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000004371 162.0
TLS2_k127_1427191_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005176 362.0
TLS2_k127_1427191_1 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000001469 224.0
TLS2_k127_1427191_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000001019 165.0
TLS2_k127_1427191_3 YGGT family K02221 - - 0.000000000000004185 79.0
TLS2_k127_1427191_4 DUF167 K09131 - - 0.0000001625 62.0
TLS2_k127_1449302_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.811e-210 677.0
TLS2_k127_1449302_1 Endonuclease Exonuclease phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 561.0
TLS2_k127_1449302_10 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000000007084 191.0
TLS2_k127_1449302_11 PFAM Uncharacterised protein family (UPF0182) K09118 - - 0.00000000000000000000000000000000000000000000000005006 186.0
TLS2_k127_1449302_12 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000006612 175.0
TLS2_k127_1449302_13 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000003362 156.0
TLS2_k127_1449302_14 MgtC family K07507 - - 0.00000000000000000000000000000000002325 140.0
TLS2_k127_1449302_15 Double zinc ribbon - - - 0.0000000000000000000000000000006585 130.0
TLS2_k127_1449302_16 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000003162 91.0
TLS2_k127_1449302_17 PFAM CAAX amino terminal protease family K07052 - - 0.00000002863 65.0
TLS2_k127_1449302_18 Zinc finger domain - - - 0.0000171 57.0
TLS2_k127_1449302_19 Belongs to the UPF0758 family K03630 - - 0.0002229 48.0
TLS2_k127_1449302_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 505.0
TLS2_k127_1449302_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 432.0
TLS2_k127_1449302_4 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 351.0
TLS2_k127_1449302_5 Phosphoribosylglycinamide synthetase, C domain K01945,K11788 GO:0008150,GO:0040007 6.3.3.1,6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009702 356.0
TLS2_k127_1449302_6 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006427 351.0
TLS2_k127_1449302_7 SAICAR synthetase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 334.0
TLS2_k127_1449302_8 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000001516 260.0
TLS2_k127_1449302_9 metal-dependent phosphohydrolase HD region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005116 268.0
TLS2_k127_1456710_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000315 587.0
TLS2_k127_1456710_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 562.0
TLS2_k127_1456710_2 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 483.0
TLS2_k127_1456710_3 Mur ligase family, catalytic domain K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 306.0
TLS2_k127_1456710_4 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000001455 225.0
TLS2_k127_1456710_5 Belongs to the UPF0234 family K09767 - - 0.0000000000000000000000000000000000000000000000000000001359 199.0
TLS2_k127_1456710_6 Competence-damaged protein K03743 - 3.5.1.42 0.0000000000000000000000000000000001683 143.0
TLS2_k127_1456710_7 Cupin 2, conserved barrel domain protein - - - 0.00000000000000003043 86.0
TLS2_k127_1456710_8 SMART helix-turn-helix domain protein - - - 0.0000000000000131 86.0
TLS2_k127_1482216_0 FeS assembly protein SufB K07033,K09014 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005488 549.0
TLS2_k127_1482216_1 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000402 143.0
TLS2_k127_1498117_0 Participates in initiation and elongation during chromosome replication K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005254 484.0
TLS2_k127_1498117_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K14161 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 372.0
TLS2_k127_1498117_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000004353 224.0
TLS2_k127_1498117_3 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000001314 204.0
TLS2_k127_1498117_4 PFAM binding-protein-dependent transport systems inner membrane component K02050 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000001805 182.0
TLS2_k127_1498117_5 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.0000000000000000000000000000000000000000000000006601 183.0
TLS2_k127_1498117_6 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000000000000000000000009147 176.0
TLS2_k127_1498117_7 Formiminotransferase-cyclodeaminase - - - 0.00000000000000000000000000000005986 136.0
TLS2_k127_1498117_8 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000002334 126.0
TLS2_k127_1498117_9 Protein of unknown function (DUF1232) - - - 0.00000000009669 74.0
TLS2_k127_1701317_0 peptidase S9B dipeptidylpeptidase IV domain protein K01278 - 3.4.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 464.0
TLS2_k127_1701317_1 sigma factor activity K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 442.0
TLS2_k127_1701317_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000002078 230.0
TLS2_k127_1701317_3 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000001009 127.0
TLS2_k127_1701317_4 YCII-related domain - - - 0.000000000000000000001639 100.0
TLS2_k127_1701317_5 PFAM Sporulation and spore germination - - - 0.000000000000003314 88.0
TLS2_k127_1701317_6 Rhodanese Homology Domain - - - 0.0000000000000051 78.0
TLS2_k127_1701317_7 EamA-like transporter family - - - 0.0000000001394 66.0
TLS2_k127_1720823_0 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative mitochondrial subgroup K00239,K00244 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009202 603.0
TLS2_k127_1720823_1 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 335.0
TLS2_k127_1720823_10 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000000000000000007227 152.0
TLS2_k127_1720823_11 Succinate dehydrogenase flavoprotein subunit K00239,K00278 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4,1.4.3.16 0.00000000000000000000000000000000000002561 154.0
TLS2_k127_1720823_12 Reverse transcriptase-like - - - 0.000000000000000000000000000000001974 134.0
TLS2_k127_1720823_13 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000000009598 109.0
TLS2_k127_1720823_14 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.000000000000000000000008044 109.0
TLS2_k127_1720823_15 - - - - 0.00001808 52.0
TLS2_k127_1720823_16 PFAM Sporulation and spore germination - - - 0.00007794 54.0
TLS2_k127_1720823_17 - - - - 0.000449 46.0
TLS2_k127_1720823_2 Penicillin-binding Protein dimerisation domain K03587,K08384 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 344.0
TLS2_k127_1720823_3 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 322.0
TLS2_k127_1720823_4 TIGRFAM stage V sporulation protein E, cell division protein FtsW K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 312.0
TLS2_k127_1720823_5 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 291.0
TLS2_k127_1720823_6 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000003457 279.0
TLS2_k127_1720823_7 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000159 262.0
TLS2_k127_1720823_8 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000001987 264.0
TLS2_k127_1720823_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000007149 213.0
TLS2_k127_1739573_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335,K18331 - 1.12.1.3,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 363.0
TLS2_k127_1739573_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008173 292.0
TLS2_k127_1739573_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001103 263.0
TLS2_k127_1739573_3 2 iron, 2 sulfur cluster binding K00334,K18330 - 1.12.1.3,1.6.5.3 0.000000000000000001864 96.0
TLS2_k127_1739573_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000001856 87.0
TLS2_k127_1775866_0 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004165 356.0
TLS2_k127_1775866_1 CsiD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 292.0
TLS2_k127_1775866_2 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001736 271.0
TLS2_k127_1775866_3 Metallo-beta-lactamase superfamily K13075 - 3.1.1.81 0.00001336 48.0
TLS2_k127_178495_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 406.0
TLS2_k127_178495_1 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 388.0
TLS2_k127_178495_2 Domain of unknown function (DUF4162) K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005883 295.0
TLS2_k127_178495_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002799 257.0
TLS2_k127_178495_4 PFAM Conserved TM helix repeat-containing protein - - - 0.000000000000000000000000000000000000000000000002489 184.0
TLS2_k127_178495_5 ABC-type Na efflux pump, permease component K01992 - - 0.000000000000000000000000000000000000000000000007546 188.0
TLS2_k127_178495_6 domain protein - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000002815 168.0
TLS2_k127_178495_7 NAD(P) transhydrogenase, alpha subunit K00324 - 1.6.1.2 0.00000000000000000000000177 118.0
TLS2_k127_178495_8 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.0000005075 62.0
TLS2_k127_180946_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 297.0
TLS2_k127_180946_1 Participates in transcription elongation, termination and antitermination K02601 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003582 260.0
TLS2_k127_180946_10 Universal stress protein family - - - 0.00000000000000000000154 109.0
TLS2_k127_180946_11 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.000000000000000001767 86.0
TLS2_k127_180946_12 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.000004529 52.0
TLS2_k127_180946_2 Beta-eliminating lyase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000001425 221.0
TLS2_k127_180946_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000001313 203.0
TLS2_k127_180946_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000000000001991 171.0
TLS2_k127_180946_5 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000001155 161.0
TLS2_k127_180946_7 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000001854 133.0
TLS2_k127_180946_8 PFAM response regulator receiver - - - 0.0000000000000000000000000005485 119.0
TLS2_k127_180946_9 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000008345 105.0
TLS2_k127_1894413_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.236e-265 829.0
TLS2_k127_1894413_1 Heat shock 70 kDa protein K04043 - - 2.42e-259 815.0
TLS2_k127_1894413_2 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000001453 253.0
TLS2_k127_1894413_3 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000005155 166.0
TLS2_k127_1894413_4 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000004283 155.0
TLS2_k127_1894413_5 VanW like protein - - - 0.000000000000000000000000000000000000003207 161.0
TLS2_k127_1894413_6 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000574 115.0
TLS2_k127_1894413_7 - - - - 0.0000005604 58.0
TLS2_k127_1908191_0 - - - - 0.000000000000000000002754 102.0
TLS2_k127_1908191_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000002161 98.0
TLS2_k127_1908191_2 Belongs to the complex I subunit 6 family K00339,K05578 - 1.6.5.3 0.000000000000000006451 93.0
TLS2_k127_1908191_3 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.00000000000004272 80.0
TLS2_k127_1908191_4 Sigma-70 region 2 K03088 - - 0.000000000002079 72.0
TLS2_k127_1908191_5 Domain of unknown function (DUF378) K09779 - - 0.00000000006247 66.0
TLS2_k127_191145_0 Bacterial capsule synthesis protein PGA_cap K07282 - - 1.429e-224 710.0
TLS2_k127_191145_1 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 509.0
TLS2_k127_191145_10 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000002019 157.0
TLS2_k127_191145_11 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000005804 114.0
TLS2_k127_191145_12 SnoaL-like domain - - - 0.0000000000000000005188 92.0
TLS2_k127_191145_13 PFAM 4Fe-4S K00176 - 1.2.7.3 0.0000000007375 65.0
TLS2_k127_191145_14 - K22014 - - 0.0000000008854 70.0
TLS2_k127_191145_15 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00177 - 1.2.7.3 0.00000006913 66.0
TLS2_k127_191145_2 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007954 312.0
TLS2_k127_191145_3 D-alanyl-D-alanine carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 302.0
TLS2_k127_191145_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001833 248.0
TLS2_k127_191145_5 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001987 247.0
TLS2_k127_191145_6 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000006337 233.0
TLS2_k127_191145_7 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000007119 207.0
TLS2_k127_191145_8 diguanylate cyclase K21023 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000005552 209.0
TLS2_k127_191145_9 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000004851 165.0
TLS2_k127_1926958_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 308.0
TLS2_k127_1926958_1 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003142 285.0
TLS2_k127_1926958_10 Transmembrane secretion effector - - - 0.0000000000000000000004194 106.0
TLS2_k127_1926958_13 Histidine kinase-like ATPases - - - 0.00000000000000001886 96.0
TLS2_k127_1926958_15 CAAX protease self-immunity - - - 0.000000000000006788 85.0
TLS2_k127_1926958_16 Histidine kinase K13924 - 2.1.1.80,3.1.1.61 0.0000002055 63.0
TLS2_k127_1926958_17 Transcriptional regulatory protein, C terminal K02483,K07659 - - 0.00004148 56.0
TLS2_k127_1926958_2 PFAM Amidohydrolase 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002156 285.0
TLS2_k127_1926958_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005107 260.0
TLS2_k127_1926958_4 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004821 256.0
TLS2_k127_1926958_5 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis K19003 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046872,GO:0071704,GO:1901576 2.4.1.336 0.00000000000000000000000000000000000000000000009429 186.0
TLS2_k127_1926958_6 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000862 152.0
TLS2_k127_1926958_8 response regulator K03413 - - 0.0000000000000000000000000000003258 127.0
TLS2_k127_1926958_9 Belongs to the 'phage' integrase family K04763 - - 0.0000000000000000000000000006644 118.0
TLS2_k127_1941893_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 3.658e-202 646.0
TLS2_k127_1941893_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 398.0
TLS2_k127_1941893_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000006123 219.0
TLS2_k127_1941893_3 PFAM YbbR family protein - - - 0.00000000000000000000000002358 123.0
TLS2_k127_1941893_4 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000007811 122.0
TLS2_k127_1941893_5 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000001025 81.0
TLS2_k127_1972668_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 6.848e-207 654.0
TLS2_k127_1972668_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 5.331e-200 629.0
TLS2_k127_1972668_2 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 334.0
TLS2_k127_1972668_3 transport, permease protein K01992 - - 0.00000000000000000000000000000000000000000000000001375 198.0
TLS2_k127_1972668_4 cytochrome c oxidase, subunit III K02276,K02299 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 0.000000000000000000000000000000000000000000002102 174.0
TLS2_k127_1972668_5 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.0000000000000000000000000000000192 135.0
TLS2_k127_1972668_6 Cytochrome C and Quinol oxidase polypeptide I K02274,K02827 - 1.10.3.12,1.9.3.1 0.00004024 51.0
TLS2_k127_2050654_0 Penicillin amidase K01434 - 3.5.1.11 2.265e-220 707.0
TLS2_k127_2050654_1 Acyl-CoA dehydrogenase, C-terminal domain K16173 - 1.3.99.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 539.0
TLS2_k127_2050654_10 Helix-turn-helix domain - - - 0.000000001204 62.0
TLS2_k127_2050654_11 Helix-turn-helix XRE-family like proteins - - - 0.00004178 55.0
TLS2_k127_2050654_12 - - - - 0.0001086 53.0
TLS2_k127_2050654_2 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005236 480.0
TLS2_k127_2050654_3 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007188 342.0
TLS2_k127_2050654_4 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 340.0
TLS2_k127_2050654_5 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 308.0
TLS2_k127_2050654_6 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007406 284.0
TLS2_k127_2050654_7 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000001186 247.0
TLS2_k127_2050654_8 Iron permease FTR1 family K07243 - - 0.0000000000000000000000000000000000000000000000000000000000007421 221.0
TLS2_k127_2050654_9 Rhomboid family K19225 - 3.4.21.105 0.0000000000000000000000000000000003537 146.0
TLS2_k127_2056632_0 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 306.0
TLS2_k127_2056632_1 PFAM peptidase S58, DmpA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000107 280.0
TLS2_k127_2056632_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000024 272.0
TLS2_k127_2056632_3 Domain of unknown function (DUF2520) - - - 0.0000000000000000000000000000000000000000003569 166.0
TLS2_k127_2056632_4 PFAM Zn-finger in ubiquitin-hydrolases and other protein - - - 0.00000000000000000000000001888 109.0
TLS2_k127_2056632_5 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000003562 111.0
TLS2_k127_206846_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 2.355e-266 856.0
TLS2_k127_2172043_0 Sodium Bile acid symporter family K03325,K03741 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006384 409.0
TLS2_k127_2172043_1 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 301.0
TLS2_k127_2172043_10 2OG-Fe(II) oxygenase superfamily K07394 - - 0.00000000000001524 84.0
TLS2_k127_2172043_11 PFAM blue (type 1) copper domain protein - - - 0.00000000000001944 79.0
TLS2_k127_2172043_12 MerR, DNA binding - - - 0.000000000001289 68.0
TLS2_k127_2172043_13 Glutaredoxin-like domain (DUF836) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000002801 67.0
TLS2_k127_2172043_2 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001202 276.0
TLS2_k127_2172043_3 water channel activity K02440,K06188,K09874 - - 0.000000000000000000000000000000000000000000000000000000000001336 218.0
TLS2_k127_2172043_4 Electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000000000000000000007453 195.0
TLS2_k127_2172043_5 Electron transfer flavoprotein K03522 - - 0.000000000000000000000000000000000000000000000004528 184.0
TLS2_k127_2172043_6 PFAM Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000002312 179.0
TLS2_k127_2172043_7 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000001089 167.0
TLS2_k127_2172043_8 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. K19519 - - 0.0000000000000000003881 96.0
TLS2_k127_2172043_9 - - - - 0.0000000000000000007561 89.0
TLS2_k127_2222048_0 ATPases associated with a variety of cellular activities K05847 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 402.0
TLS2_k127_2222048_1 F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000007822 225.0
TLS2_k127_2222048_2 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000000000000000000000005111 206.0
TLS2_k127_2222048_3 Binding-protein-dependent transport system inner membrane component K05846 - - 0.00000000000000000000000000000000000000000000000000000005424 203.0
TLS2_k127_2222048_4 transport K05845,K05846 - - 0.000000000000000000000000000000000000000000000000000006307 198.0
TLS2_k127_2222048_5 Substrate binding domain of ABC-type glycine betaine transport system K05845 - - 0.00000000000000000000000000000000000000007823 163.0
TLS2_k127_2222048_6 Dodecin - - - 0.00000000006931 63.0
TLS2_k127_2222048_7 TPM domain K06872 - - 0.000000006782 69.0
TLS2_k127_2222048_8 membrane - - - 0.00000002739 65.0
TLS2_k127_2259312_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 2.033e-256 813.0
TLS2_k127_2259312_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 454.0
TLS2_k127_2259312_10 Membrane - - - 0.0000000000000000000000000004979 120.0
TLS2_k127_2259312_11 Bacterial Ig-like domain K06894 - - 0.00000000000000000001517 107.0
TLS2_k127_2259312_12 Phosphoglycerate mutase - - - 0.00000000000000000009483 97.0
TLS2_k127_2259312_13 RDD family - - - 0.0000000000000000001133 97.0
TLS2_k127_2259312_14 Involved in the tonB-independent uptake of proteins - - - 0.00000000336 70.0
TLS2_k127_2259312_2 tRNA binding K04566 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 432.0
TLS2_k127_2259312_3 TIGRFAM RNA polymerase sigma-54 factor, RpoN K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000805 355.0
TLS2_k127_2259312_4 Belongs to the peptidase M16 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 312.0
TLS2_k127_2259312_5 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000001488 233.0
TLS2_k127_2259312_6 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000008251 190.0
TLS2_k127_2259312_7 Domain of unknown function (DUF4111) K00984 - 2.7.7.47 0.000000000000000000000000000000000000000000000000001122 198.0
TLS2_k127_2259312_8 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000001599 149.0
TLS2_k127_2259312_9 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000008269 140.0
TLS2_k127_2284900_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 2.738e-215 683.0
TLS2_k127_2284900_1 Cytochrome b/b6/petB K03891 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 497.0
TLS2_k127_2284900_2 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004672 413.0
TLS2_k127_2284900_3 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 339.0
TLS2_k127_2284900_4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.0000000000000000000000000000000000000000000003504 175.0
TLS2_k127_2284900_5 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000001606 120.0
TLS2_k127_2284900_6 PFAM isochorismatase hydrolase K08281 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 0.00000000000000000000001502 102.0
TLS2_k127_241430_0 UDP binding domain K02472,K13015 - 1.1.1.136,1.1.1.336 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 441.0
TLS2_k127_241430_1 aromatic amino acid beta-eliminating lyase threonine aldolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 419.0
TLS2_k127_241430_10 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 0.000000000000000000001984 109.0
TLS2_k127_241430_11 Hexapeptide repeat of succinyl-transferase - - - 0.00000000000000001931 83.0
TLS2_k127_241430_2 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 383.0
TLS2_k127_241430_3 PFAM oxidoreductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 316.0
TLS2_k127_241430_4 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000006356 265.0
TLS2_k127_241430_5 TIGRFAM MazG family protein K02499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009876 258.0
TLS2_k127_241430_6 Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000002183 231.0
TLS2_k127_241430_7 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000205 220.0
TLS2_k127_241430_8 DinB superfamily - - - 0.0000000000000000000000000000000000000002201 156.0
TLS2_k127_241430_9 cell envelope-related transcriptional attenuator - - - 0.000000000000000000000000000006307 133.0
TLS2_k127_2432730_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007153 522.0
TLS2_k127_2432730_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835,K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 432.0
TLS2_k127_2432730_10 phosphinothricin N-acetyltransferase activity K03830 - - 0.00000000000000000000000000000000000000000000006422 185.0
TLS2_k127_2432730_11 galactose-6-phosphate isomerase activity K00761,K01808 - 2.4.2.9,5.3.1.6 0.000000000000000000000000000000000000000535 158.0
TLS2_k127_2432730_12 Telomere recombination K07566 - 2.7.7.87 0.00000000000000000000000000000000008496 144.0
TLS2_k127_2432730_13 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109,K02113 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000001166 124.0
TLS2_k127_2432730_14 Protein of unknown function DUF126 K09128 - - 0.00000000000000000000000000005459 123.0
TLS2_k127_2432730_15 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000002941 121.0
TLS2_k127_2432730_16 Ribosomal L27 protein K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000001483 114.0
TLS2_k127_2432730_17 Binds the 23S rRNA K02909 - - 0.00000000000000000000003951 105.0
TLS2_k127_2432730_18 ATP synthase F(0) sector subunit b K02109 - - 0.000000000000000007139 90.0
TLS2_k127_2432730_19 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000001111 79.0
TLS2_k127_2432730_2 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 420.0
TLS2_k127_2432730_20 Uncharacterized protein conserved in bacteria (DUF2344) - - - 0.0000000000008621 83.0
TLS2_k127_2432730_21 PFAM penicillin-binding protein transpeptidase K05515 - 3.4.16.4 0.00000000001472 70.0
TLS2_k127_2432730_22 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.000005871 52.0
TLS2_k127_2432730_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005448 274.0
TLS2_k127_2432730_4 Protein of unknown function (DUF1385) K09153 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002276 263.0
TLS2_k127_2432730_5 Inosine-uridine preferring nucleoside hydrolase K01239 - 3.2.2.1 0.0000000000000000000000000000000000000000000000000000000000001301 235.0
TLS2_k127_2432730_6 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000001133 219.0
TLS2_k127_2432730_7 phosphinothricin N-acetyltransferase activity K03830 - - 0.000000000000000000000000000000000000000000000000008118 193.0
TLS2_k127_2432730_8 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000003141 189.0
TLS2_k127_2432730_9 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.00000000000000000000000000000000000000000000000388 188.0
TLS2_k127_2432956_0 luxR family - - - 0.0 1159.0
TLS2_k127_2432956_1 Epoxide hydrolase N terminus - - - 0.00000000000000000000000000000000003538 138.0
TLS2_k127_2519436_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 2.683e-206 675.0
TLS2_k127_2519436_1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000001735 254.0
TLS2_k127_2519436_2 PFAM sigma-70 region 2 domain protein K03088 - - 0.00000000000000000000000000000000000000008083 166.0
TLS2_k127_2519436_3 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859,K07566 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24,2.7.7.87 0.000000000000000000000000000000000001432 149.0
TLS2_k127_2519436_4 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.0000000000000000000002195 108.0
TLS2_k127_2519436_5 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000002933 99.0
TLS2_k127_2519436_6 DnaJ molecular chaperone homology domain K05516 - - 0.00000000000111 75.0
TLS2_k127_2519436_7 SAF K02279 - - 0.00001996 56.0
TLS2_k127_2548586_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003217 580.0
TLS2_k127_2548586_1 VanW like protein - - - 0.0000000007401 68.0
TLS2_k127_2548586_2 Binds directly to 16S ribosomal RNA K02968 - - 0.000000005922 64.0
TLS2_k127_2548586_3 Belongs to the phosphoglycerate kinase family K00927 GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3 0.00001323 47.0
TLS2_k127_2887521_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004713 602.0
TLS2_k127_2887521_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 409.0
TLS2_k127_2887521_2 V-type ATPase 116kDa subunit family K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 312.0
TLS2_k127_2887521_3 ATP synthase subunit C K02124 - - 0.000000000000327 83.0
TLS2_k127_2887521_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000006755 55.0
TLS2_k127_2887648_0 Binding-protein-dependent transport system inner membrane component K02033,K15581 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006609 266.0
TLS2_k127_2887648_1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.0000000000000000000000000000000000000000000000000000166 201.0
TLS2_k127_2887648_2 Glucose-6-phosphate dehydrogenase subunit - - - 0.000000000000000000000000000000000000000005747 171.0
TLS2_k127_2887648_3 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000003468 145.0
TLS2_k127_2894159_0 PFAM Xanthine uracil vitamin C permease K06901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 485.0
TLS2_k127_2894159_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 431.0
TLS2_k127_2894159_2 Protein of unknown function (DUF2905) - - - 0.0000000000002118 73.0
TLS2_k127_2894159_3 MobA-related protein K07141,K19190 - 1.1.1.328,2.7.7.76 0.000000000001077 74.0
TLS2_k127_2941473_0 Glycosyl hydrolases family 15 - - - 1.34e-317 985.0
TLS2_k127_2941473_1 citrate synthase K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 584.0
TLS2_k127_2941473_10 Polymer-forming cytoskeletal - - - 0.00000000000001322 83.0
TLS2_k127_2941473_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 406.0
TLS2_k127_2941473_3 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008142 281.0
TLS2_k127_2941473_4 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000003308 237.0
TLS2_k127_2941473_5 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000001709 214.0
TLS2_k127_2941473_6 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000004357 182.0
TLS2_k127_2941473_7 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000004956 181.0
TLS2_k127_2941473_8 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000001059 95.0
TLS2_k127_2941473_9 glyoxalase III activity - - - 0.00000000000000000002763 95.0
TLS2_k127_2942345_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002391 248.0
TLS2_k127_2942345_1 domain protein K06881 - 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000004695 208.0
TLS2_k127_2942345_2 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000000000001414 206.0
TLS2_k127_2942345_3 Belongs to the ribF family K11753 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000004028 158.0
TLS2_k127_2942345_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000000008114 111.0
TLS2_k127_2987882_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 2.471e-228 720.0
TLS2_k127_3004461_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1339.0
TLS2_k127_3004461_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005301 549.0
TLS2_k127_3004461_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001948 282.0
TLS2_k127_3004461_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000001517 240.0
TLS2_k127_3004461_4 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000005095 192.0
TLS2_k127_3004461_5 DNA helicase K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000005224 201.0
TLS2_k127_3004461_6 TRANSCRIPTIONal - - - 0.00000000000000000000000000000000000000023 169.0
TLS2_k127_3004461_7 PFAM phosphoesterase, RecJ domain protein K07462 - - 0.000000000000000000000000000000000804 137.0
TLS2_k127_3004461_8 Methyltransferase domain K07003 - - 0.000000000000000000000000005716 126.0
TLS2_k127_3013880_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 519.0
TLS2_k127_3013880_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00647,K09458 - 2.3.1.179,2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 451.0
TLS2_k127_3013880_2 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008125 280.0
TLS2_k127_3013880_3 PFAM NUDIX domain - - - 0.00000000000000000000000000000000000000002529 162.0
TLS2_k127_3013880_4 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000003961 139.0
TLS2_k127_3013880_5 Peptidase dimerisation domain - - - 0.0000000000000000000000003519 108.0
TLS2_k127_3079559_0 Glycosyl transferase 4-like domain K08256 - 2.4.1.345 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 335.0
TLS2_k127_3079559_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005809 316.0
TLS2_k127_3079559_10 Phage shock protein C, PspC K03973 - - 0.0000000000000004461 87.0
TLS2_k127_3079559_2 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007392 295.0
TLS2_k127_3079559_3 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000001441 231.0
TLS2_k127_3079559_4 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000002408 210.0
TLS2_k127_3079559_5 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000003394 183.0
TLS2_k127_3079559_6 Glycosyl transferase K00728 - 2.4.1.109 0.0000000000000000000000000000000000000000004977 183.0
TLS2_k127_3079559_7 Protein of unknown function (DUF2723) - - - 0.000000000000000000000000000000007517 146.0
TLS2_k127_3079559_8 lipid A biosynthesis acyltransferase K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.0000000000000000000000000000001284 135.0
TLS2_k127_3079559_9 lipid A biosynthesis acyltransferase K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.00000000000000000000000000378 123.0
TLS2_k127_3174741_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005163 461.0
TLS2_k127_3174741_1 Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 444.0
TLS2_k127_3174741_10 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.000000000000000000000000000004745 127.0
TLS2_k127_3174741_11 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000343 119.0
TLS2_k127_3174741_12 - - - - 0.000000000000000000000000009486 111.0
TLS2_k127_3174741_13 4Fe-4S binding domain K00176 - 1.2.7.3 0.000000000000000002399 94.0
TLS2_k127_3174741_14 Hemerythrin HHE cation binding domain - - - 0.000000000000000009399 90.0
TLS2_k127_3174741_15 EamA-like transporter family - - - 0.0000000000000001377 91.0
TLS2_k127_3174741_16 EamA-like transporter family K11939 - - 0.00000000000003068 84.0
TLS2_k127_3174741_17 LamG domain protein jellyroll fold domain protein - - - 0.0000000004803 71.0
TLS2_k127_3174741_18 VIT family - - - 0.00004051 55.0
TLS2_k127_3174741_19 Transcriptional regulator - - - 0.0000764 51.0
TLS2_k127_3174741_2 PFAM Pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004655 412.0
TLS2_k127_3174741_20 Non-essential cell division protein that could be required for efficient cell constriction - - - 0.0002748 54.0
TLS2_k127_3174741_3 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 399.0
TLS2_k127_3174741_4 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 307.0
TLS2_k127_3174741_5 Subtilase family K08651,K14743 - 3.4.21.66 0.0000000000000000000000000000000000000000000000000000000000000000000000002999 272.0
TLS2_k127_3174741_6 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000006772 242.0
TLS2_k127_3174741_7 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000003527 173.0
TLS2_k127_3174741_8 PFAM Pyruvate ketoisovalerate oxidoreductase K00177 - 1.2.7.3 0.0000000000000000000000000000000000000000005542 163.0
TLS2_k127_3174741_9 Trypsin-like serine protease - - - 0.000000000000000000000000000000000000000000562 171.0
TLS2_k127_3175297_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000003228 200.0
TLS2_k127_3175297_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000002836 143.0
TLS2_k127_3175297_2 Cyclic-di-AMP receptor - - - 0.0000000000000000000000000000000001125 137.0
TLS2_k127_3175297_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000004414 119.0
TLS2_k127_3175297_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.0000000000000000000006462 99.0
TLS2_k127_3175297_5 GTP binding - - - 0.000000000000001777 88.0
TLS2_k127_3175297_6 DinB superfamily - - - 0.00026 50.0
TLS2_k127_3175297_7 membrane - - - 0.000888 49.0
TLS2_k127_3367139_0 protein methyltransferase activity K11434,K15984,K20421 - 2.1.1.242,2.1.1.303,2.1.1.319 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 447.0
TLS2_k127_3367139_1 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008267 382.0
TLS2_k127_3367139_2 Threonyl alanyl tRNA synthetase SAD K07050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001269 281.0
TLS2_k127_3367139_3 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000003402 222.0
TLS2_k127_3367139_4 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000002643 218.0
TLS2_k127_3367139_5 peptidase activity K01286 - 3.4.16.4 0.000000000000000000000000000000000000002485 164.0
TLS2_k127_3367139_6 Transmembrane secretion effector - - - 0.000000000000002177 79.0
TLS2_k127_3367139_7 Bacterial regulatory proteins, tetR family - - - 0.000000000709 68.0
TLS2_k127_3514190_0 Flavin containing amine oxidoreductase - - - 1.156e-245 774.0
TLS2_k127_3514190_1 ATPases associated with a variety of cellular activities K16786,K16787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006129 573.0
TLS2_k127_3514190_10 - - - - 0.00007287 49.0
TLS2_k127_3514190_11 Helix-turn-helix domain - - - 0.0001281 53.0
TLS2_k127_3514190_12 Serine aminopeptidase, S33 K06889 - - 0.0002852 53.0
TLS2_k127_3514190_2 Glycine cleavage T-protein C-terminal barrel domain K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000449 478.0
TLS2_k127_3514190_3 3'-5' exonuclease activity K03547 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 425.0
TLS2_k127_3514190_4 cobalt transport K16785 - - 0.0000000000000000000000000000000000000000000000000000000002411 214.0
TLS2_k127_3514190_5 membrane K16925 - - 0.00000000000000000000000000000000000000000000000000009809 194.0
TLS2_k127_3514190_6 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000006556 174.0
TLS2_k127_3514190_7 PFAM Thiamin pyrophosphokinase, catalytic region K00949 - 2.7.6.2 0.000000000000000000000000000000000000000177 160.0
TLS2_k127_3514190_8 YbaK prolyl-tRNA synthetase associated region - - - 0.00000000000000000000000000000000000001031 162.0
TLS2_k127_3514190_9 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.00000000001662 76.0
TLS2_k127_3542089_0 Na+/H+ antiporter 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002342 533.0
TLS2_k127_3542089_1 Protein of unknown function (DUF1684) K09164 - - 0.0000000000000000000000000000000001504 135.0
TLS2_k127_355004_0 UPF0365 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008864 399.0
TLS2_k127_355004_1 Membrane-bound serine protease (ClpP class) K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 312.0
TLS2_k127_3585992_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 364.0
TLS2_k127_3585992_1 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000002663 230.0
TLS2_k127_3585992_2 PFAM GGDEF domain containing protein K13590 - 2.7.7.65 0.0000000199 61.0
TLS2_k127_3622051_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 562.0
TLS2_k127_3622051_1 Cys/Met metabolism PLP-dependent enzyme K00639 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 522.0
TLS2_k127_3622051_2 L-threonine 3-dehydrogenase K00060 - 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 359.0
TLS2_k127_3622051_3 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002438 249.0
TLS2_k127_3622051_4 Two component transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000000000000000000004613 231.0
TLS2_k127_3622051_5 Integral membrane sensor signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000005168 217.0
TLS2_k127_3622051_6 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.000000000000000000000000000000000000000000000000000003195 204.0
TLS2_k127_3622051_7 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000000004521 111.0
TLS2_k127_3622051_8 ubiE/COQ5 methyltransferase family - - - 0.000000000007684 74.0
TLS2_k127_3680473_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 507.0
TLS2_k127_3680473_1 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000339 235.0
TLS2_k127_3680473_2 3-demethylubiquinone-9 3-methyltransferase K04750 - - 0.00000000000000000000000000000000000000000001255 166.0
TLS2_k127_3680473_3 Domain of unknown function (DUF309) K09763 - - 0.000000000000002017 88.0
TLS2_k127_3680473_4 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000006116 60.0
TLS2_k127_3680473_5 chaperone K05516 - - 0.0000002523 62.0
TLS2_k127_3692708_0 Putative modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 520.0
TLS2_k127_3692708_1 Putative modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000002631 248.0
TLS2_k127_3692708_10 PFAM Major Facilitator Superfamily - - - 0.000000000000000001246 97.0
TLS2_k127_3692708_11 Bacterial protein of unknown function (DUF881) - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000002103 93.0
TLS2_k127_3692708_12 Bacterial protein of unknown function (DUF881) - - - 0.000000000000000005957 95.0
TLS2_k127_3692708_13 protein, homolog of Cu resistance protein CopC K07245,K14166 - - 0.0000000000000001348 86.0
TLS2_k127_3692708_14 cytochrome c K00405,K07245 - - 0.000000000000002866 90.0
TLS2_k127_3692708_15 Bacterial protein of unknown function (DUF951) - - - 0.00000000000004768 85.0
TLS2_k127_3692708_16 MerR, DNA binding K19591 - - 0.0000000000002158 74.0
TLS2_k127_3692708_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000002869 227.0
TLS2_k127_3692708_3 domain, Protein - - - 0.0000000000000000000000000000000000000000000000479 189.0
TLS2_k127_3692708_4 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000000000000000000000000000000001199 146.0
TLS2_k127_3692708_5 Small Multidrug Resistance protein K03297 - - 0.000000000000000000000000000443 117.0
TLS2_k127_3692708_6 Protein of unknown function, DUF - - - 0.000000000000000000000000001293 118.0
TLS2_k127_3692708_7 copper resistance D domain protein K14166 - - 0.000000000000000000000001937 120.0
TLS2_k127_3692708_8 Peptidase MA superfamily - - - 0.000000000000000000001241 109.0
TLS2_k127_3692708_9 - - - - 0.000000000000000000001827 96.0
TLS2_k127_3699358_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 352.0
TLS2_k127_3699358_1 serine threonine protein kinase K08282,K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000001773 244.0
TLS2_k127_3699358_2 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000001633 250.0
TLS2_k127_3699358_3 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000001978 218.0
TLS2_k127_3699358_4 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000001983 186.0
TLS2_k127_3699358_5 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000002925 167.0
TLS2_k127_3699358_6 cheY-homologous receiver domain - - - 0.0000000000000000000000001337 118.0
TLS2_k127_3699358_8 ABC-type transport system involved in multi-copper enzyme maturation, permease K01992 - - 0.0000002311 61.0
TLS2_k127_3699358_9 Protein of unknown function (DUF998) - - - 0.000001053 58.0
TLS2_k127_3747157_0 ABC transporter K06147 - - 1.423e-241 762.0
TLS2_k127_3747157_1 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 635.0
TLS2_k127_3747157_2 Pfam Uncharacterised protein family UPF0047 - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000006616 195.0
TLS2_k127_3747157_3 Cell envelope-like function transcriptional attenuator common domain protein - - - 0.000000000000000000000003123 113.0
TLS2_k127_3809890_0 E1-E2 ATPase K01533 - 3.6.3.4 2.586e-246 779.0
TLS2_k127_3809890_1 Amino acid permease - - - 3.571e-206 661.0
TLS2_k127_3809890_10 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005922 283.0
TLS2_k127_3809890_11 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000447 286.0
TLS2_k127_3809890_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005713 282.0
TLS2_k127_3809890_13 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001148 272.0
TLS2_k127_3809890_15 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003844 259.0
TLS2_k127_3809890_16 Protein of unknown function (DUF998) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006695 243.0
TLS2_k127_3809890_17 Transcriptional regulatory protein, C terminal K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000009847 237.0
TLS2_k127_3809890_18 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000000000000000000000000000001067 228.0
TLS2_k127_3809890_19 GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000006686 228.0
TLS2_k127_3809890_2 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 554.0
TLS2_k127_3809890_20 Protein of unknown function (DUF2938) - - - 0.0000000000000000000000000000000000000000000000000000002706 198.0
TLS2_k127_3809890_21 F420H(2)-dependent quinone reductase - - - 0.0000000000000000000000000000000000000000000000000000008162 197.0
TLS2_k127_3809890_22 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000000000000000000000000000000003416 196.0
TLS2_k127_3809890_23 - - - - 0.000000000000000000000000000000000000000000000001269 184.0
TLS2_k127_3809890_24 Carboxylate--amine ligase - - - 0.0000000000000000000000000000000000000000001461 172.0
TLS2_k127_3809890_25 COG1668 ABC-type Na efflux pump, permease component - - - 0.000000000000000000000000000000000000002085 158.0
TLS2_k127_3809890_26 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000001234 143.0
TLS2_k127_3809890_27 FeoA K01356,K03709 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.0000000000000000000000000000000001514 142.0
TLS2_k127_3809890_28 cyclic nucleotide binding K01420,K10914 - - 0.000000000000000000000000000008876 126.0
TLS2_k127_3809890_29 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000002339 123.0
TLS2_k127_3809890_3 PFAM ABC transporter related K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007838 453.0
TLS2_k127_3809890_30 RDD family - - - 0.00000000000000000000000000271 117.0
TLS2_k127_3809890_31 - - - - 0.000000000000000000004145 104.0
TLS2_k127_3809890_32 Flavodoxin K03809 - 1.6.5.2 0.00000000000000000002349 102.0
TLS2_k127_3809890_33 Polymer-forming cytoskeletal - - - 0.000000000000008064 89.0
TLS2_k127_3809890_34 Transglycosylase associated protein - - - 0.0000000000001082 82.0
TLS2_k127_3809890_35 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000004976 78.0
TLS2_k127_3809890_36 Chaperone protein DNAj - GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - 0.000000005289 66.0
TLS2_k127_3809890_37 DNA binding - - - 0.0000001079 63.0
TLS2_k127_3809890_38 Multicopper oxidase K00368 - 1.7.2.1 0.000302 48.0
TLS2_k127_3809890_4 ABC-type sugar transport system periplasmic component K10232 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 363.0
TLS2_k127_3809890_5 ABC-type sugar transport system, permease component K10234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 356.0
TLS2_k127_3809890_6 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006837 359.0
TLS2_k127_3809890_7 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 322.0
TLS2_k127_3809890_8 PFAM Binding-protein-dependent transport system inner membrane component K02025,K10233 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 302.0
TLS2_k127_3809890_9 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001358 289.0
TLS2_k127_3850257_0 ABC transporter K06022,K06158,K10834 - 3.6.3.29,3.6.3.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 569.0
TLS2_k127_3850257_1 Peptidase family S58 K01266 - 3.4.11.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007259 475.0
TLS2_k127_3850257_10 histidine kinase, dimerisation and phosphoacceptor region - - - 0.000000000000000000000000000000000000000000000000000002392 221.0
TLS2_k127_3850257_11 endonuclease III K03575 - - 0.00000000000000000000000000000000000000000000000000001039 211.0
TLS2_k127_3850257_12 ACT domain K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000132 199.0
TLS2_k127_3850257_13 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.00000000000000000000000000000000000000000000639 175.0
TLS2_k127_3850257_14 Uncharacterized ACR, COG1993 K09137 - - 0.00000000000000000000000000000000000002781 153.0
TLS2_k127_3850257_15 Lysyl oxidase - - - 0.0000000000000000000000000000000000001073 158.0
TLS2_k127_3850257_16 PFAM Haloacid dehalogenase domain protein hydrolase K07025 - - 0.0000000000000000000000000000007431 131.0
TLS2_k127_3850257_17 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000006027 116.0
TLS2_k127_3850257_18 L-asparaginase II - - - 0.00000000000000000000001339 106.0
TLS2_k127_3850257_19 EamA-like transporter family K03298 - - 0.0000000000000002184 92.0
TLS2_k127_3850257_2 glutamate-tRNA ligase activity K01885,K09698 - 6.1.1.17,6.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 424.0
TLS2_k127_3850257_20 response regulator - - - 0.0000001061 58.0
TLS2_k127_3850257_21 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000001782 63.0
TLS2_k127_3850257_3 Putative cell wall binding repeat 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 366.0
TLS2_k127_3850257_4 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 310.0
TLS2_k127_3850257_5 PFAM Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000003058 258.0
TLS2_k127_3850257_6 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001346 254.0
TLS2_k127_3850257_7 alcohol dehydrogenase K13953,K18382 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000002929 255.0
TLS2_k127_3850257_8 helix_turn_helix, Lux Regulon K02479 - - 0.000000000000000000000000000000000000000000000000000000000666 214.0
TLS2_k127_3850257_9 Protein of unknown function (DUF554) K07150 - - 0.0000000000000000000000000000000000000000000000000000003098 203.0
TLS2_k127_3859630_0 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006204 297.0
TLS2_k127_3859630_1 PFAM Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001494 272.0
TLS2_k127_3859630_2 AI-2E family transporter - - - 0.000000000003499 75.0
TLS2_k127_3871555_0 SMART alpha amylase catalytic sub domain K01187 - 3.2.1.20 9.691e-212 668.0
TLS2_k127_3871555_1 FtsX-like permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 457.0
TLS2_k127_3871555_2 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006214 372.0
TLS2_k127_3871555_3 Methyltransferase type 11 K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 343.0
TLS2_k127_3871555_4 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003359 291.0
TLS2_k127_3871555_5 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001438 252.0
TLS2_k127_3871555_6 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000003431 240.0
TLS2_k127_3871555_7 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000000000000000000000001158 160.0
TLS2_k127_3871555_8 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000001812 89.0
TLS2_k127_3897462_0 Acetyl-coenzyme A synthetase N-terminus K01907 - 6.2.1.16 4.538e-226 713.0
TLS2_k127_3897462_1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K11381,K21416,K21417 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 619.0
TLS2_k127_3897462_2 Dehydrogenase K00140 - 1.2.1.18,1.2.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005076 559.0
TLS2_k127_3897462_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002513 469.0
TLS2_k127_3897462_4 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 339.0
TLS2_k127_3897462_5 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007009 338.0
TLS2_k127_3897462_6 e3 binding domain K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009835 290.0
TLS2_k127_3897462_7 PFAM regulatory protein GntR HTH K22293 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001998 259.0
TLS2_k127_3897462_8 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000003987 100.0
TLS2_k127_3897462_9 Calcineurin-like phosphoesterase K07313 - 3.1.3.16 0.00000000000000001538 94.0
TLS2_k127_4054922_0 Natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 394.0
TLS2_k127_4054922_1 MgtE intracellular N domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006433 370.0
TLS2_k127_4054922_2 Aldehyde dehydrogenase K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004516 360.0
TLS2_k127_4054922_3 PHP domain protein K02347 - - 0.000000000000000000000000000000000000000003625 166.0
TLS2_k127_4054922_4 Putative stress-induced transcription regulator - - - 0.0000000000000000001578 100.0
TLS2_k127_4057862_0 TIGRFAM methylmalonyl-CoA mutase, large subunit K01848 - 5.4.99.2 2.519e-220 698.0
TLS2_k127_4057862_1 Helix-hairpin-helix domain K04477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009008 425.0
TLS2_k127_4057862_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 406.0
TLS2_k127_4057862_3 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 332.0
TLS2_k127_4057862_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005638 267.0
TLS2_k127_4057862_5 metal-dependent hydrolase with the TIM-barrel fold K07048 - - 0.000000000000000000000000000000000000000000000000000000000000000002128 239.0
TLS2_k127_4057862_6 Stage II sporulation protein - - - 0.0000000000000000000000000000003018 136.0
TLS2_k127_4057862_7 Dodecin - - - 0.0000000000000004068 93.0
TLS2_k127_412150_0 DegT/DnrJ/EryC1/StrS aminotransferase family K04127 - 5.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 383.0
TLS2_k127_412150_1 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000000000000000000001112 221.0
TLS2_k127_4136984_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 337.0
TLS2_k127_4136984_1 DRTGG domain K06873 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000611 286.0
TLS2_k127_4136984_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000005997 250.0
TLS2_k127_4136984_3 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000001062 216.0
TLS2_k127_4136984_4 PFAM HhH-GPD family protein - - - 0.0000000000000000000000000000000000000000000000000000002701 203.0
TLS2_k127_4155705_0 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 3.222e-262 841.0
TLS2_k127_4155705_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 357.0
TLS2_k127_4155705_2 Zincin-like metallopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001499 291.0
TLS2_k127_4155705_3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000002533 243.0
TLS2_k127_4155705_4 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000004544 225.0
TLS2_k127_4155705_5 NUBPL iron-transfer P-loop NTPase K02282 - - 0.00000000000000000000000000000000000000000000004215 184.0
TLS2_k127_4155705_6 Methyltransferase type 12 - - - 0.000000000000000000003726 108.0
TLS2_k127_4155705_7 Bacterial transcriptional activator domain K03556 - - 0.000000001096 72.0
TLS2_k127_417041_0 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 494.0
TLS2_k127_417041_1 Nickel-dependent hydrogenase K00436 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005168 455.0
TLS2_k127_417041_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00596,K00823 - 2.6.1.19,4.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 355.0
TLS2_k127_417041_3 NADH ubiquinone oxidoreductase, 20 Kd subunit K14128 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000409 288.0
TLS2_k127_417041_4 CobW/HypB/UreG, nucleotide-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003225 256.0
TLS2_k127_417041_5 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.00000000000000001256 94.0
TLS2_k127_417041_6 spore germination K03605 - - 0.00000001102 68.0
TLS2_k127_4237870_0 ATPases associated with a variety of cellular activities K16786,K16787 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003486 248.0
TLS2_k127_4237870_1 Psort location CytoplasmicMembrane, score K02006,K16786,K16787 - - 0.0000000000000000000000000000000000000000000000000006345 204.0
TLS2_k127_4237870_2 phosphorelay sensor kinase activity K16923,K18967 - 2.7.7.65 0.0000000000000000000000000000000000000000004412 171.0
TLS2_k127_4237870_3 Cobalt transport protein K02008,K16785 - - 0.000000000000000000000000000000000000000013 164.0
TLS2_k127_4237870_4 PFAM inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000001013 161.0
TLS2_k127_4237870_5 PFAM NUDIX hydrolase - - - 0.00000000000000000000000000002475 130.0
TLS2_k127_4237870_6 membrane - - - 0.000000000000000000005996 99.0
TLS2_k127_4237870_7 TIGRFAM TIGR02588 family protein - - - 0.0000000000002341 76.0
TLS2_k127_427376_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 338.0
TLS2_k127_427376_1 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627,K09699 - 2.3.1.12,2.3.1.168 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000261 281.0
TLS2_k127_427376_2 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002315 257.0
TLS2_k127_427376_3 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000008485 213.0
TLS2_k127_427376_4 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K00153,K01069 - 1.1.1.306,3.1.2.6 0.00000000000000000000000004319 122.0
TLS2_k127_427376_5 Acetyltransferase (GNAT) family - - - 0.0000000000000005574 91.0
TLS2_k127_4338270_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 3.906e-260 832.0
TLS2_k127_4338270_1 AAA ATPase, central domain protein K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 439.0
TLS2_k127_4338270_10 Protein of unknown function (DUF4446) - - - 0.00000000000000000000000001591 121.0
TLS2_k127_4338270_11 Belongs to the phosphoglycerate mutase family K22305 - 3.1.3.3 0.0000000000000000000000001067 120.0
TLS2_k127_4338270_12 Regulatory protein, FmdB family - - - 0.0000000000000000009908 90.0
TLS2_k127_4338270_13 PFAM Forkhead-associated protein - - - 0.00000000000000008976 90.0
TLS2_k127_4338270_14 sequence-specific DNA binding - - - 0.00000003828 60.0
TLS2_k127_4338270_15 Elongation factor SelB, winged helix K03833 - - 0.0004168 51.0
TLS2_k127_4338270_2 ATPase associated with various cellular K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 434.0
TLS2_k127_4338270_3 Cell cycle protein K03588,K05364,K05837 GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000053 345.0
TLS2_k127_4338270_4 Aminotransferase class-V K00436 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 311.0
TLS2_k127_4338270_5 PFAM penicillin-binding protein transpeptidase K05364 - - 0.00000000000000000000000000000000000000000000000000000000000000000002778 251.0
TLS2_k127_4338270_6 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000112 229.0
TLS2_k127_4338270_7 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000001009 213.0
TLS2_k127_4338270_8 PFAM response regulator receiver K02282 - - 0.00000000000000000000000000000000000000001056 169.0
TLS2_k127_4338270_9 PFAM Forkhead-associated protein - - - 0.0000000000000000000000000000000000009223 151.0
TLS2_k127_4479380_0 Cache domain - - - 0.000000000000000000000000000000001177 147.0
TLS2_k127_4479380_1 Protein of unknown function (DUF3048) C-terminal domain - - - 0.00000000000000000000003143 113.0
TLS2_k127_450086_0 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007268 419.0
TLS2_k127_450086_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 347.0
TLS2_k127_450086_2 CBS domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 304.0
TLS2_k127_450086_3 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000003499 261.0
TLS2_k127_450086_4 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000001419 233.0
TLS2_k127_450086_5 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000008768 208.0
TLS2_k127_450086_6 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000000001988 189.0
TLS2_k127_450086_7 endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000037 147.0
TLS2_k127_450086_8 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.000000000000000000000000000000000001018 150.0
TLS2_k127_450086_9 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000002189 145.0
TLS2_k127_4575987_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 9.789e-194 627.0
TLS2_k127_4575987_1 tRNA synthetases class I (W and Y) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 539.0
TLS2_k127_4575987_10 peptide catabolic process - - - 0.0000000000000000000000000000000007834 147.0
TLS2_k127_4575987_11 CoA binding domain K06929 - - 0.00000000000000000000000000000009795 132.0
TLS2_k127_4575987_12 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000005575 132.0
TLS2_k127_4575987_13 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000001267 113.0
TLS2_k127_4575987_14 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000000000000005948 123.0
TLS2_k127_4575987_15 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.00000000000000000000000006021 111.0
TLS2_k127_4575987_16 Probable zinc-ribbon domain - - - 0.0000000000000000000000001425 109.0
TLS2_k127_4575987_17 transferase activity, transferring acyl groups - - - 0.0000000000000000000000001965 118.0
TLS2_k127_4575987_18 OHCU decarboxylase - - - 0.0000000000000000000001205 110.0
TLS2_k127_4575987_19 Tetratricopeptide repeat - - - 0.000000000000000000001314 100.0
TLS2_k127_4575987_2 Amidohydrolase family K01464,K01466 - 3.5.2.2,3.5.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 340.0
TLS2_k127_4575987_20 Adenylate K01768 - 4.6.1.1 0.000000000000004274 86.0
TLS2_k127_4575987_3 PFAM glycosyl transferase, family 51 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 348.0
TLS2_k127_4575987_4 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 331.0
TLS2_k127_4575987_5 Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - 0.0000000000000000000000000000000000000000000000000000000000000000000001778 247.0
TLS2_k127_4575987_6 bis(5'-adenosyl)-triphosphatase activity - - - 0.000000000000000000000000000000000000002318 157.0
TLS2_k127_4575987_7 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000004511 152.0
TLS2_k127_4575987_8 Protein of unknown function (DUF3830) - - - 0.00000000000000000000000000000000000001474 149.0
TLS2_k127_4575987_9 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000002066 149.0
TLS2_k127_4578821_0 Uncharacterised protein family (UPF0261) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 560.0
TLS2_k127_4578821_1 RIO1 family K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000002528 181.0
TLS2_k127_4578821_2 DEAD DEAH box helicase domain protein - - - 0.0000000000000000000000000000000000000000002775 163.0
TLS2_k127_4578821_3 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000001796 116.0
TLS2_k127_4589326_0 MutL protein K00854 - 2.7.1.17 0.000000000000000000000000000000000000000043 175.0
TLS2_k127_4589326_1 PFAM Uncharacterised P-loop hydrolase UPF0079 K06925 - - 0.000000000000000000000000000000252 134.0
TLS2_k127_4589326_2 - - - - 0.0000000000000000000000002304 118.0
TLS2_k127_4589326_3 pseudouridine synthase activity K06178,K06181,K06183 - 5.4.99.19,5.4.99.20,5.4.99.22 0.000000007841 66.0
TLS2_k127_4589326_4 - - - - 0.00000009435 64.0
TLS2_k127_4589326_5 Glycoprotease family - - - 0.0000006999 59.0
TLS2_k127_4651297_0 Multicopper oxidase K00368 - 1.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 461.0
TLS2_k127_4651297_1 Starch synthase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 356.0
TLS2_k127_4651297_2 DEAD DEAH box helicase domain protein K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 324.0
TLS2_k127_4651297_3 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006961 319.0
TLS2_k127_4651297_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001026 255.0
TLS2_k127_4651297_5 Two component transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001188 237.0
TLS2_k127_4651297_6 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000002268 204.0
TLS2_k127_4651297_7 F420H(2)-dependent quinone reductase - - - 0.0000000000000000000000000001711 119.0
TLS2_k127_4651297_8 Aminotransferase class-V K04487 GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.7 0.0000000000001428 77.0
TLS2_k127_4693678_0 PFAM ABC transporter related K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 594.0
TLS2_k127_4693678_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 482.0
TLS2_k127_4693678_10 PFAM basic membrane lipoprotein K07335 - - 0.0000000000000000000000000000000000000000000000000000004876 207.0
TLS2_k127_4693678_11 Haloacid dehalogenase-like hydrolase - GO:0000121,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030145,GO:0042578,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0046475,GO:0046486,GO:0046503,GO:0046872,GO:0046914,GO:0046983,GO:0050897,GO:0071704,GO:1901575 - 0.0000000000000000000000000000000000000000002051 173.0
TLS2_k127_4693678_12 pfam nudix K01515 - 3.6.1.13 0.0000000000000000000000000000000000006355 153.0
TLS2_k127_4693678_13 TIGRFAM phosphodiesterase, MJ0936 - - - 0.00000000000000000000000000000000001023 144.0
TLS2_k127_4693678_14 aminopeptidase N - - - 0.000000000000000000000000004089 129.0
TLS2_k127_4693678_15 Peptidase, M23 K21471 - - 0.0000000000000000000000007113 120.0
TLS2_k127_4693678_16 Tetratricopeptide repeat - - - 0.000000000000000000000004705 109.0
TLS2_k127_4693678_17 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000003301 81.0
TLS2_k127_4693678_18 Belongs to the UPF0337 (CsbD) family - - - 0.00000005559 65.0
TLS2_k127_4693678_19 COG0419 ATPase involved in DNA repair K03546 - - 0.0005671 49.0
TLS2_k127_4693678_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007048 417.0
TLS2_k127_4693678_20 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0008077 46.0
TLS2_k127_4693678_3 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 361.0
TLS2_k127_4693678_4 PFAM glycosyl transferase, family 51 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 336.0
TLS2_k127_4693678_5 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005026 311.0
TLS2_k127_4693678_6 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007718 281.0
TLS2_k127_4693678_7 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001819 283.0
TLS2_k127_4693678_8 Adenosine/AMP deaminase - - - 0.00000000000000000000000000000000000000000000000000000000002461 231.0
TLS2_k127_4693678_9 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000005439 227.0
TLS2_k127_4704855_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005793 437.0
TLS2_k127_4704855_1 ATPase with chaperone activity K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 430.0
TLS2_k127_4704855_2 PFAM response regulator receiver K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000002269 239.0
TLS2_k127_4704855_3 DNA recombination-mediator protein A K04096 - - 0.000000000000000000000000000000000000000000000000004339 204.0
TLS2_k127_4704855_4 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000003999 150.0
TLS2_k127_4704855_5 protein with SCP PR1 domains - - - 0.0000000000001959 83.0
TLS2_k127_4704855_6 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.000000000000518 72.0
TLS2_k127_4704855_7 response to copper ion - - - 0.0000565 56.0
TLS2_k127_4713025_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 497.0
TLS2_k127_4713025_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 485.0
TLS2_k127_4713025_2 Acyl-CoA dehydrogenase, N-terminal domain K00248,K00249 - 1.3.8.1,1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 402.0
TLS2_k127_4713025_3 PFAM peptidase M1, membrane alanine aminopeptidase - - - 0.00000000000000000000000000000268 137.0
TLS2_k127_4713025_4 ECF sigma factor K03088 - - 0.0000000000000000000000008588 111.0
TLS2_k127_4713025_5 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000001886 107.0
TLS2_k127_4713025_6 PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.00000000000000000002488 91.0
TLS2_k127_485509_0 RimK-like ATP-grasp domain K03802 - 6.3.2.29,6.3.2.30 0.0 1159.0
TLS2_k127_485509_1 Amylo-alpha-1,6-glucosidase - - - 3.91e-236 755.0
TLS2_k127_485509_10 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000003917 176.0
TLS2_k127_485509_11 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.000000000000000000000000001153 118.0
TLS2_k127_485509_12 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000008018 111.0
TLS2_k127_485509_13 Protein of unknown function (DUF3105) - - - 0.00000000000000001801 93.0
TLS2_k127_485509_14 PAS fold - - - 0.0000000000000007838 91.0
TLS2_k127_485509_15 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000000001742 70.0
TLS2_k127_485509_16 DnaJ domain - GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006109,GO:0006457,GO:0008150,GO:0009507,GO:0009536,GO:0009889,GO:0009987,GO:0010322,GO:0010565,GO:0010675,GO:0019216,GO:0019220,GO:0019222,GO:0019747,GO:0031323,GO:0031326,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046890,GO:0050789,GO:0050790,GO:0050794,GO:0051174,GO:0051338,GO:0061077,GO:0062012,GO:0065007,GO:0065009,GO:0071071,GO:0080090,GO:1902395,GO:1903725 - 0.000003477 59.0
TLS2_k127_485509_2 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 4.444e-232 737.0
TLS2_k127_485509_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 530.0
TLS2_k127_485509_4 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005305 463.0
TLS2_k127_485509_5 Tetratrico peptide repeat K03802 - 6.3.2.29,6.3.2.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 349.0
TLS2_k127_485509_6 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004963 338.0
TLS2_k127_485509_7 Peptidase family S51 K13282 - 3.4.15.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009742 325.0
TLS2_k127_485509_8 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006931 292.0
TLS2_k127_485509_9 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004151 280.0
TLS2_k127_4862594_0 PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 486.0
TLS2_k127_4862594_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001841 274.0
TLS2_k127_4862594_2 FabA-like domain K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000001054 200.0
TLS2_k127_4878451_0 decarboxylase K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 479.0
TLS2_k127_4878451_1 TrkA-N domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006298 468.0
TLS2_k127_4878451_2 Aminotransferase class-III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 450.0
TLS2_k127_4878451_3 PAS domain - - - 0.00000000000000000000000000001839 122.0
TLS2_k127_4878451_4 AAA domain - - - 0.000000000000000000008083 103.0
TLS2_k127_488115_0 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 329.0
TLS2_k127_488115_1 Belongs to the peptidase S41A family - - - 0.00000000000000000000000000000008241 136.0
TLS2_k127_488115_2 peptidyl-tyrosine sulfation - - - 0.0000000001717 63.0
TLS2_k127_4926616_0 Fe-S oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 521.0
TLS2_k127_4926616_1 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006879 430.0
TLS2_k127_4926616_2 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004321 405.0
TLS2_k127_4926616_3 Membrane - - - 0.000000000000000000000000000000000000000000000003759 184.0
TLS2_k127_4926616_4 AsnC family K03718 - - 0.00000000000000000000000000000000000000000000405 168.0
TLS2_k127_4926616_5 Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000007632 116.0
TLS2_k127_4964748_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 313.0
TLS2_k127_4964748_1 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002786 285.0
TLS2_k127_4964748_2 DoxX K16937 - 1.8.5.2 0.000000000000000000000000000000000000000000000000000000000001841 221.0
TLS2_k127_4964748_3 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000009032 183.0
TLS2_k127_4964748_4 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000009819 153.0
TLS2_k127_4964748_5 Cbs domain - - - 0.000000000000000001115 91.0
TLS2_k127_5039052_0 CoA-binding K09181 - - 0.0 1167.0
TLS2_k127_5039052_1 malic protein domain protein K00027 - 1.1.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 565.0
TLS2_k127_5039052_10 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000003496 227.0
TLS2_k127_5039052_11 Sodium:sulfate symporter transmembrane region K14445 - - 0.000000000000000000000000000000000000000000000000000000000002293 230.0
TLS2_k127_5039052_12 Belongs to the pseudouridine synthase RsuA family K06178,K06182 - 5.4.99.21,5.4.99.22 0.00000000000000000000000000000000000000000000000000000000003828 224.0
TLS2_k127_5039052_13 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000751 202.0
TLS2_k127_5039052_14 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000002111 180.0
TLS2_k127_5039052_15 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000002444 174.0
TLS2_k127_5039052_16 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.0000000000000000000000000000000000000002109 161.0
TLS2_k127_5039052_17 Peptidase M50 - - - 0.000000000000000000000000000000000000009888 152.0
TLS2_k127_5039052_18 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000544 146.0
TLS2_k127_5039052_19 PFAM membrane-flanked domain - - - 0.000000000000000000000000002689 122.0
TLS2_k127_5039052_2 GTPase that plays an essential role in the late steps of ribosome biogenesis K00058,K03977 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 490.0
TLS2_k127_5039052_20 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000001201 112.0
TLS2_k127_5039052_21 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000007862 108.0
TLS2_k127_5039052_22 PFAM HD domain - - - 0.00000000000009402 77.0
TLS2_k127_5039052_3 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000784 411.0
TLS2_k127_5039052_4 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 359.0
TLS2_k127_5039052_5 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 334.0
TLS2_k127_5039052_6 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 306.0
TLS2_k127_5039052_7 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 303.0
TLS2_k127_5039052_8 integrase domain protein SAM domain protein K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001003 273.0
TLS2_k127_5039052_9 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000001727 248.0
TLS2_k127_5052404_0 PFAM FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004672 514.0
TLS2_k127_5052404_1 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 462.0
TLS2_k127_5052404_2 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 394.0
TLS2_k127_5052404_3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000002493 246.0
TLS2_k127_5052404_4 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000005039 193.0
TLS2_k127_5052404_5 4Fe-4S binding domain - - - 0.00000000000000000000000001242 113.0
TLS2_k127_5052404_6 Aminoacyl-tRNA editing domain K19055 - - 0.0000000000000000003837 95.0
TLS2_k127_5052404_7 COG3119 Arylsulfatase A and related enzymes - - - 0.0003415 46.0
TLS2_k127_5103583_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 516.0
TLS2_k127_5103583_1 Required for morphogenesis under gluconeogenic growth conditions - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 371.0
TLS2_k127_5103583_10 Preprotein translocase SecG subunit K03075 - - 0.0000000000005766 71.0
TLS2_k127_5103583_2 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006888 265.0
TLS2_k127_5103583_3 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001032 244.0
TLS2_k127_5103583_4 DHH family K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000006318 235.0
TLS2_k127_5103583_5 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000001706 223.0
TLS2_k127_5103583_6 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000839 188.0
TLS2_k127_5103583_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000499 172.0
TLS2_k127_5103583_8 May be required for sporulation K09762 - - 0.0000000000000000000000000000000002803 143.0
TLS2_k127_5103583_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000003972 74.0
TLS2_k127_5132026_0 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 506.0
TLS2_k127_5132026_1 Beta-eliminating lyase K01667,K01668 - 4.1.99.1,4.1.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 480.0
TLS2_k127_5132026_10 nuclease activity K18828 - - 0.00003689 53.0
TLS2_k127_5132026_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009114 448.0
TLS2_k127_5132026_3 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000001023 232.0
TLS2_k127_5132026_4 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000001365 221.0
TLS2_k127_5132026_5 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000004862 220.0
TLS2_k127_5132026_6 Cytochrome c oxidase caa3-type, assembly factor CtaG-related K02351,K07245 - - 0.0000000000000000000000000000000000000000000000000000004651 206.0
TLS2_k127_5132026_7 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.00000000000000000000000000000000000000000001174 176.0
TLS2_k127_5132026_8 - - - - 0.00000000000000000000001353 117.0
TLS2_k127_5132026_9 - - - - 0.000000496 55.0
TLS2_k127_5270324_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 3.7e-216 684.0
TLS2_k127_5270324_1 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 589.0
TLS2_k127_5270324_10 - - - - 0.000000000000000006324 86.0
TLS2_k127_5270324_2 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000976 343.0
TLS2_k127_5270324_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000001536 219.0
TLS2_k127_5270324_4 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 0.000000000000000000000000000000000000000000000000000003083 193.0
TLS2_k127_5270324_5 Belongs to the UPF0145 family - - - 0.00000000000000000000000000000000000000008154 157.0
TLS2_k127_5270324_6 MOSC domain - - - 0.0000000000000000000000000000000006346 137.0
TLS2_k127_5270324_7 Clp amino terminal domain, pathogenicity island component - - - 0.0000000000000000000000000000002661 132.0
TLS2_k127_5270324_9 Bacterial transcription activator, effector binding domain - - - 0.00000000000000000000000615 110.0
TLS2_k127_5296186_0 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 347.0
TLS2_k127_5296186_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 331.0
TLS2_k127_5296186_2 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000001443 231.0
TLS2_k127_5296186_3 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000299 208.0
TLS2_k127_5296186_4 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000004305 152.0
TLS2_k127_5296186_5 protein serine/threonine phosphatase activity - - - 0.000001373 62.0
TLS2_k127_5336029_0 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 496.0
TLS2_k127_5336029_1 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 362.0
TLS2_k127_5336029_10 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000000000000000000000006164 104.0
TLS2_k127_5336029_11 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000000000000000001219 110.0
TLS2_k127_5336029_12 Cytochrome C and Quinol oxidase polypeptide I K00404 - 1.9.3.1 0.000000000000000000003584 108.0
TLS2_k127_5336029_13 - - - - 0.00000000000006631 80.0
TLS2_k127_5336029_14 - - - - 0.00000001682 57.0
TLS2_k127_5336029_15 - - - - 0.0002646 46.0
TLS2_k127_5336029_2 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002343 274.0
TLS2_k127_5336029_3 PFAM Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000000000000000000000000000000001124 239.0
TLS2_k127_5336029_4 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000007695 217.0
TLS2_k127_5336029_5 helix_turn_helix, mercury resistance K22491 - - 0.0000000000000000000000000000000000000000000000000000001238 207.0
TLS2_k127_5336029_6 Belongs to the glycosyl hydrolase 26 family - - - 0.00000000000000000000000000000000000000000000000000001705 199.0
TLS2_k127_5336029_7 serine-type peptidase activity - - - 0.0000000000000000000000000000000000000009747 158.0
TLS2_k127_5336029_8 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000109 147.0
TLS2_k127_5336029_9 translation release factor activity K03265 - - 0.00000000000000000000000003782 122.0
TLS2_k127_5340120_0 F420-dependent oxidoreductase, G6PDH family K15510 - 1.1.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 473.0
TLS2_k127_5340120_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000001033 199.0
TLS2_k127_5340120_2 FR47-like protein - - - 0.00000000000000000000000000000000000000000000000007016 188.0
TLS2_k127_5340120_3 Pfam Pyridoxamine 5'-phosphate - - - 0.000000000000000000000000001442 114.0
TLS2_k127_5340120_4 - - - - 0.000000000006424 75.0
TLS2_k127_5341840_0 Cytidylyltransferase K00983 - 2.7.7.43 0.00000000000000000000000000002665 119.0
TLS2_k127_5341840_1 PFAM O-Antigen K18814 - - 0.0000000000000016 90.0
TLS2_k127_5341840_2 COG2148 Sugar transferases involved in lipopolysaccharide synthesis - - - 0.000003056 49.0
TLS2_k127_5507885_0 response regulator - - - 0.00000000000000000000000000000000000002096 154.0
TLS2_k127_5507885_1 Histidine kinase K03406,K07673,K07675 - 2.7.13.3 0.000000000000000000000000001954 128.0
TLS2_k127_5644308_0 ABC transporter, phosphonate, periplasmic substrate-binding protein K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 387.0
TLS2_k127_5644308_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 356.0
TLS2_k127_5644308_10 transcriptional regulator, Rrf2 family K13643 - - 0.0000000000000000000000000000000000000000008893 175.0
TLS2_k127_5644308_11 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000009014 163.0
TLS2_k127_5644308_12 serine-type peptidase activity K01061,K06889 - 3.1.1.45 0.00000000000000000000000000000000000000009874 164.0
TLS2_k127_5644308_13 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000261 155.0
TLS2_k127_5644308_14 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000004386 161.0
TLS2_k127_5644308_15 OsmC-like protein K04063 - - 0.000000000000000000000000000000000005576 144.0
TLS2_k127_5644308_16 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000001447 143.0
TLS2_k127_5644308_17 HDOD domain - - - 0.0000000000000000000000000003577 128.0
TLS2_k127_5644308_18 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.000000000000000000000007284 111.0
TLS2_k127_5644308_19 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000002242 106.0
TLS2_k127_5644308_2 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 333.0
TLS2_k127_5644308_20 PFAM sigma-70 region 2 domain protein K03088 - - 0.000000000000000000002296 109.0
TLS2_k127_5644308_21 Galactose oxidase, central domain - - - 0.00000000000001473 85.0
TLS2_k127_5644308_22 membrane K00389 - - 0.000000002593 68.0
TLS2_k127_5644308_23 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01535,K01537,K12955 GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.6,3.6.3.8 0.00007547 49.0
TLS2_k127_5644308_24 Putative zinc-finger - - - 0.0008231 52.0
TLS2_k127_5644308_3 galactose-1-phosphate uridylyltransferase K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 334.0
TLS2_k127_5644308_4 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 308.0
TLS2_k127_5644308_5 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 311.0
TLS2_k127_5644308_6 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006478 277.0
TLS2_k127_5644308_7 phosphoenolpyruvate carboxykinase (ATP) activity K01610 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019318,GO:0019319,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 4.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000272 290.0
TLS2_k127_5644308_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000008611 235.0
TLS2_k127_5644308_9 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000001128 228.0
TLS2_k127_56779_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008154 349.0
TLS2_k127_56779_1 integral membrane protein - - - 0.00000000000000000000000000000000000000001031 160.0
TLS2_k127_56779_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000001375 112.0
TLS2_k127_5715038_0 calcium, potassium:sodium antiporter activity K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 485.0
TLS2_k127_5715038_1 PFAM glycoside hydrolase family 10 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000774 307.0
TLS2_k127_5715038_2 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003018 243.0
TLS2_k127_5715038_3 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000002644 144.0
TLS2_k127_5715038_4 - - - - 0.00000000000000000000000000000001847 137.0
TLS2_k127_5715038_5 Secreted repeat of unknown function - - - 0.00000000000000000000000000000341 132.0
TLS2_k127_5715038_6 - - - - 0.0000000000000000000000001585 107.0
TLS2_k127_5715038_7 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000004471 112.0
TLS2_k127_5733287_0 Carboxyl transferase domain K01969 - 6.4.1.4 6.773e-247 771.0
TLS2_k127_5733287_1 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 517.0
TLS2_k127_5733287_10 Glyoxalase-like domain - - - 0.0000000000000000001556 98.0
TLS2_k127_5733287_11 Pfam:DUF59 - - - 0.00000003341 56.0
TLS2_k127_5733287_12 SseB protein N-terminal domain - - - 0.0004573 52.0
TLS2_k127_5733287_2 Cation transport protein K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 422.0
TLS2_k127_5733287_3 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006926 330.0
TLS2_k127_5733287_4 Enoyl-CoA hydratase/isomerase K13766,K13779 - 4.2.1.18,4.2.1.57 0.0000000000000000000000000000000000000000000000000000000000000000000001473 252.0
TLS2_k127_5733287_5 TrkA-C domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000001832 235.0
TLS2_k127_5733287_6 TIGRFAM LPXTG-motif cell wall anchor domain - - - 0.000000000000000000000000000000000000001088 160.0
TLS2_k127_5733287_7 Putative tRNA binding domain K06878 - - 0.00000000000000000000000000000001412 130.0
TLS2_k127_5733287_8 N-acetylglucosaminylinositol deacetylase activity K22135 - - 0.00000000000000000000000000004848 125.0
TLS2_k127_5733287_9 PFAM GGDEF domain containing protein - - - 0.0000000000000000000007883 110.0
TLS2_k127_5734068_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 7.331e-218 701.0
TLS2_k127_5873498_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 475.0
TLS2_k127_5873498_1 Peptidase, family M20 M25 M40 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 447.0
TLS2_k127_5873498_10 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000003151 163.0
TLS2_k127_5873498_11 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000006004 132.0
TLS2_k127_5873498_12 - - - - 0.000000000000000000000000000000001081 139.0
TLS2_k127_5873498_13 Transcriptional regulator - - - 0.000000000000000000000000001705 123.0
TLS2_k127_5873498_14 Helix-turn-helix domain - - - 0.0000000000000000000000002916 115.0
TLS2_k127_5873498_15 JAB/MPN domain K21140 - 3.13.1.6 0.00000000000000000004343 104.0
TLS2_k127_5873498_16 PFAM Phospholipid glycerol acyltransferase - - - 0.0000000000000000001946 101.0
TLS2_k127_5873498_17 of nitrite reductase and ring-hydroxylating K05710 - - 0.00000000000000003631 88.0
TLS2_k127_5873498_18 - - - - 0.0000000001426 70.0
TLS2_k127_5873498_19 D-glucuronyl C5-epimerase C-terminus - - - 0.00001851 59.0
TLS2_k127_5873498_2 Cysteine synthase K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004446 422.0
TLS2_k127_5873498_3 PFAM UBA THIF-type NAD FAD binding protein K21029,K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 398.0
TLS2_k127_5873498_4 PFAM peptidase M24 K01262,K01271,K01274 - 3.4.11.9,3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 382.0
TLS2_k127_5873498_5 PFAM ABC transporter related K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004723 331.0
TLS2_k127_5873498_6 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000003424 208.0
TLS2_k127_5873498_7 COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component K09015 - - 0.0000000000000000000000000000000000000000000000003818 186.0
TLS2_k127_5873498_8 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000006164 162.0
TLS2_k127_5873498_9 NifU-like N terminal domain K04488 - - 0.00000000000000000000000000000000000007733 147.0
TLS2_k127_5908876_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1123.0
TLS2_k127_5908876_1 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004853 319.0
TLS2_k127_5908876_2 ABC-2 type transporter - - - 0.000000000000000000000000000000000000000000000001024 186.0
TLS2_k127_5908876_3 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000293 158.0
TLS2_k127_5908876_4 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000009153 118.0
TLS2_k127_5908876_5 CHRD domain - - - 0.0000000000000004558 85.0
TLS2_k127_5908876_6 Putative adhesin - - - 0.0000000000005847 81.0
TLS2_k127_5908876_7 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0006457,GO:0008150,GO:0009987 - 0.00000007795 61.0
TLS2_k127_5962401_0 ATPase P-type (Transporting), HAD superfamily, subfamily IC - - - 0.0 1054.0
TLS2_k127_5962401_1 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 2.455e-305 979.0
TLS2_k127_5962401_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001664 260.0
TLS2_k127_5962401_3 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000003037 239.0
TLS2_k127_5962401_4 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000007309 145.0
TLS2_k127_5962401_5 - - - - 0.00000000000000000000000597 109.0
TLS2_k127_5962401_6 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.00000000000000000001009 98.0
TLS2_k127_5962401_7 Response regulator, receiver - - - 0.000000000000002163 86.0
TLS2_k127_5962401_8 HesB YadR YfhF-family protein - - - 0.000000004754 62.0
TLS2_k127_5996408_0 xanthine dehydrogenase activity - - - 6.608e-206 666.0
TLS2_k127_5996408_1 Malate synthase K01638 - 2.3.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 545.0
TLS2_k127_5996408_2 Amidohydrolase family K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 382.0
TLS2_k127_5996408_3 xanthine dehydrogenase activity K13479 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000005882 222.0
TLS2_k127_5996408_4 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000001727 192.0
TLS2_k127_5996408_5 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000000001366 186.0
TLS2_k127_6059731_0 Threonine synthase K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006718 431.0
TLS2_k127_6059731_1 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 372.0
TLS2_k127_6059731_2 Aminotransferase class I and II K11358 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009916 284.0
TLS2_k127_6059731_3 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000001457 199.0
TLS2_k127_6059731_4 NADPH-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000008494 148.0
TLS2_k127_6059731_5 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000007399 137.0
TLS2_k127_6059731_6 Predicted integral membrane protein (DUF2269) - - - 0.00000000000000000000000002858 118.0
TLS2_k127_6059731_7 Alpha/beta hydrolase family - - - 0.0000000000000000000001509 109.0
TLS2_k127_6059731_8 - - - - 0.00000000000000004562 88.0
TLS2_k127_6059731_9 PFAM Acetyltransferase (GNAT) family - - - 0.000005405 57.0
TLS2_k127_6085880_0 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000004985 223.0
TLS2_k127_6085880_1 Permease for cytosine/purines, uracil, thiamine, allantoin K03457 - - 0.0000000000000000000000000000000000000000000000000000000000005151 215.0
TLS2_k127_6085880_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K11747 - - 0.00000000000000000000000000000000000003587 149.0
TLS2_k127_6100023_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 9.056e-307 974.0
TLS2_k127_6100023_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 490.0
TLS2_k127_6100023_10 Acetyltransferase (GNAT) domain - - - 0.000000000000000001174 93.0
TLS2_k127_6100023_11 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000008345 69.0
TLS2_k127_6100023_12 SMART Metal-dependent phosphohydrolase, HD - - - 0.0000000008487 66.0
TLS2_k127_6100023_13 HupF/HypC family K04653 - - 0.000002636 53.0
TLS2_k127_6100023_14 - - - - 0.0005763 44.0
TLS2_k127_6100023_2 TipAS antibiotic-recognition domain K21744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 301.0
TLS2_k127_6100023_3 PFAM ComEC Rec2-related protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000644 320.0
TLS2_k127_6100023_4 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000008299 244.0
TLS2_k127_6100023_5 - - - - 0.0000000000000000000000000000000000000000000000000000000001113 224.0
TLS2_k127_6100023_6 Methyltransferase domain - - - 0.0000000000000000000000000000000327 137.0
TLS2_k127_6100023_8 Helix-hairpin-helix motif K02237 - - 0.0000000000000000000000001796 115.0
TLS2_k127_6101429_0 ATP-dependent DNA helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004426 419.0
TLS2_k127_6101429_1 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.00000000000000000000000000000000000000000000000000000000000005066 226.0
TLS2_k127_6101429_2 YCII-related domain - - - 0.0000000000000001524 84.0
TLS2_k127_629560_0 major pilin protein fima - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008842 273.0
TLS2_k127_629560_1 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000002014 259.0
TLS2_k127_629560_2 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000002587 165.0
TLS2_k127_629560_3 MMPL family K06994,K20470 - - 0.000000000000000000000000000001035 141.0
TLS2_k127_629560_4 ACT domain protein - - - 0.00000000000000000000006246 109.0
TLS2_k127_6304899_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 585.0
TLS2_k127_6304899_1 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000004295 232.0
TLS2_k127_6304899_2 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 0.00000000000000000000000000000000000000000000000000000000009956 212.0
TLS2_k127_6304899_3 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.000000000000000000000000000000000000000004474 165.0
TLS2_k127_6304899_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K00999 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 0.0000000000000000000000000000000593 134.0
TLS2_k127_6304899_5 ABC transporter, ATP-binding protein K01990 - - 0.000000000000000004454 94.0
TLS2_k127_6304899_6 DNA-binding transcription factor activity K03892 - - 0.00000000000002892 77.0
TLS2_k127_6304899_7 peptidase C60 sortase A and B - - - 0.0004037 52.0
TLS2_k127_6307263_0 FAD linked oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 466.0
TLS2_k127_6307263_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 438.0
TLS2_k127_6307263_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 326.0
TLS2_k127_6307263_3 Imidazolone-5-propionate hydrolase K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000055 278.0
TLS2_k127_6307263_4 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000004655 266.0
TLS2_k127_6307263_5 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000001082 221.0
TLS2_k127_6307263_6 XdhC and CoxI family - - - 0.0000000000000000000000000000000000000000000000000002199 195.0
TLS2_k127_6307263_7 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000007296 181.0
TLS2_k127_6307263_8 Transcriptional regulator - - - 0.00000000000000000000000000001022 132.0
TLS2_k127_6427157_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01840 - 5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005355 291.0
TLS2_k127_6427157_1 glutamine-fructose-6-phosphate transaminase (isomerizing) activity K00820,K15916 - 2.6.1.16,5.3.1.8,5.3.1.9 0.00000000000000000000000000000000002653 143.0
TLS2_k127_646742_0 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000003612 239.0
TLS2_k127_646742_1 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000002524 199.0
TLS2_k127_646742_2 Domain of unknown function (DUF296) K06934 - - 0.0000000000000000000000000006311 132.0
TLS2_k127_6518093_0 AAA domain, putative AbiEii toxin, Type IV TA system K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 454.0
TLS2_k127_6518093_1 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005046 312.0
TLS2_k127_6518093_10 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000002673 115.0
TLS2_k127_6518093_11 - - - - 0.00007549 48.0
TLS2_k127_6518093_2 ABC-2 type transporter K09694 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002234 259.0
TLS2_k127_6518093_3 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002492 259.0
TLS2_k127_6518093_4 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000001388 239.0
TLS2_k127_6518093_5 Transport permease protein K09694 - - 0.000000000000000000000000000000000000000000000000000000001063 222.0
TLS2_k127_6518093_6 Belongs to the UPF0173 family - - - 0.000000000000000000000000000000000000000000000000008077 190.0
TLS2_k127_6518093_7 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000003419 150.0
TLS2_k127_6518093_8 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000001139 134.0
TLS2_k127_6518093_9 - - - - 0.0000000000000000000000000000003827 141.0
TLS2_k127_6578388_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 538.0
TLS2_k127_6578388_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 530.0
TLS2_k127_6578388_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008245 289.0
TLS2_k127_6578388_3 Mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001125 286.0
TLS2_k127_6578388_4 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000001236 231.0
TLS2_k127_6578388_5 PFAM YibE F-like protein - - - 0.00000000000000000000000000000000000000000000000001105 194.0
TLS2_k127_6578388_6 Domain of unknown function (DUF374) K09778 - - 0.000000000000001633 87.0
TLS2_k127_6611484_0 Aromatic amino acid lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000007533 184.0
TLS2_k127_6611484_1 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000007343 141.0
TLS2_k127_6611484_2 Phosphoesterase, PA-phosphatase related K19302 - 3.6.1.27 0.000000000003384 76.0
TLS2_k127_6666862_0 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000001388 216.0
TLS2_k127_6666862_1 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000001705 175.0
TLS2_k127_6666862_2 Zn peptidase - - - 0.00000000000000000000000000000000000000006527 167.0
TLS2_k127_6666862_3 domain protein - - - 0.000000000000004392 84.0
TLS2_k127_6695622_0 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008239 598.0
TLS2_k127_6695622_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 442.0
TLS2_k127_6695622_2 oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 315.0
TLS2_k127_6695622_3 TatD related DNase K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000006055 198.0
TLS2_k127_6695622_4 Oxidoreductase NAD-binding domain K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000001874 158.0
TLS2_k127_6695622_5 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000006665 142.0
TLS2_k127_6695622_6 DinB family - - - 0.000000000000000000000000000000001565 136.0
TLS2_k127_6695622_7 PFAM single-strand binding protein Primosomal replication protein n K03111 - - 0.0000000000000000000000000000008916 126.0
TLS2_k127_6695622_9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679 - 0.0001282 46.0
TLS2_k127_6709098_0 Aconitase C-terminal domain K01681 - 4.2.1.3 0.0 1095.0
TLS2_k127_6709098_1 PFAM Protein kinase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 338.0
TLS2_k127_6709098_2 Domain of unknown function (DUF4162) K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001156 254.0
TLS2_k127_6709098_3 SdpI/YhfL protein family - - - 0.00000000000000000000000000000000000001699 155.0
TLS2_k127_6709098_4 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.000000000000009433 87.0
TLS2_k127_6709098_5 Phospholipase_D-nuclease N-terminal - - - 0.000000000003181 70.0
TLS2_k127_6709098_6 SnoaL-like polyketide cyclase - - - 0.0000003236 58.0
TLS2_k127_672535_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 3.368e-228 721.0
TLS2_k127_672535_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004823 475.0
TLS2_k127_672535_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001013 284.0
TLS2_k127_672535_3 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109,K02113 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000004534 117.0
TLS2_k127_672535_4 ATP synthesis coupled proton transport K02109 - - 0.0000000000008865 73.0
TLS2_k127_675386_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.017e-269 852.0
TLS2_k127_675386_1 PFAM ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 319.0
TLS2_k127_675386_2 DnaJ molecular chaperone homology domain K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000000000000003627 229.0
TLS2_k127_675386_3 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000002099 174.0
TLS2_k127_675386_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000002963 140.0
TLS2_k127_675386_5 helix_turn_helix, mercury resistance K13640 - - 0.00000000000000002326 88.0
TLS2_k127_6800314_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 377.0
TLS2_k127_6800314_1 phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 341.0
TLS2_k127_6800314_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005417 291.0
TLS2_k127_6800314_3 phosphate transport system permease K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000001033 257.0
TLS2_k127_6800314_4 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000001462 228.0
TLS2_k127_6800314_5 PFAM ATP-binding region, ATPase domain protein K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000524 217.0
TLS2_k127_6800314_6 YceI-like domain - - - 0.0000000000000000000000000000000000000000000000000000003149 199.0
TLS2_k127_6800314_7 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000005166 168.0
TLS2_k127_6800314_8 Belongs to the glycosyl hydrolase 2 family K01195 - 3.2.1.31 0.00000000000000001173 98.0
TLS2_k127_6800314_9 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000003056 60.0
TLS2_k127_6907297_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 382.0
TLS2_k127_6907297_1 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003898 321.0
TLS2_k127_6907297_10 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000009961 97.0
TLS2_k127_6907297_11 - - - - 0.0000002875 54.0
TLS2_k127_6907297_2 PFAM Sodium calcium exchanger membrane region K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003741 280.0
TLS2_k127_6907297_3 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000325 268.0
TLS2_k127_6907297_4 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000009452 192.0
TLS2_k127_6907297_5 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000001695 127.0
TLS2_k127_6907297_6 NUBPL iron-transfer P-loop NTPase K02282 - - 0.0000000000000000000000000005914 128.0
TLS2_k127_6907297_7 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000004412 116.0
TLS2_k127_6907297_8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000000008631 111.0
TLS2_k127_6907297_9 F420H(2)-dependent quinone reductase - - - 0.0000000000000000000000005491 108.0
TLS2_k127_6909349_0 ABC-type Fe3 -siderophore transport system, permease component K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001764 267.0
TLS2_k127_6909349_1 PFAM ABC transporter related K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000002198 216.0
TLS2_k127_6909349_2 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000000000000000000000000000000000000000000000000001251 200.0
TLS2_k127_6909349_3 permease - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.0000000000000000000000000000009889 138.0
TLS2_k127_6909349_4 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.000000000000000000000008768 104.0
TLS2_k127_6921775_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 457.0
TLS2_k127_6921775_1 Dehydrogenase K00166 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 372.0
TLS2_k127_6921775_2 PFAM Transketolase central region K00167 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000002188 250.0
TLS2_k127_6921775_3 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000005552 115.0
TLS2_k127_6921775_4 Peptidase dimerisation domain K01295 - 3.4.17.11 0.0000000000000000002219 89.0
TLS2_k127_7016836_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 612.0
TLS2_k127_7016836_1 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 563.0
TLS2_k127_7016836_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00001187 54.0
TLS2_k127_7016836_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 491.0
TLS2_k127_7016836_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009674 345.0
TLS2_k127_7016836_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000811 286.0
TLS2_k127_7016836_5 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000004695 200.0
TLS2_k127_7016836_6 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000001473 200.0
TLS2_k127_7016836_7 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000003892 146.0
TLS2_k127_7016836_8 Ribosomal protein L35 K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000004377 73.0
TLS2_k127_7016836_9 PFAM Colicin V production protein K03558 - - 0.000004913 56.0
TLS2_k127_7123864_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 2.473e-196 634.0
TLS2_k127_7123864_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 571.0
TLS2_k127_7123864_10 Alpha beta hydrolase - - - 0.0000008531 61.0
TLS2_k127_7123864_2 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007916 355.0
TLS2_k127_7123864_3 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000595 309.0
TLS2_k127_7123864_4 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000009163 243.0
TLS2_k127_7123864_5 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000774 225.0
TLS2_k127_7123864_6 Histidine triad (HIT) protein K02503 - - 0.00000000000000000000000000000000004004 138.0
TLS2_k127_7123864_7 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000002207 96.0
TLS2_k127_7123864_8 Transcriptional regulator - - - 0.000000000000000002451 89.0
TLS2_k127_7144712_0 Histidine ammonia-lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 421.0
TLS2_k127_7144712_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 335.0
TLS2_k127_7144712_2 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000001913 197.0
TLS2_k127_7144712_3 PIN domain - - - 0.0000000000000000000000000000001342 128.0
TLS2_k127_7144712_4 Protein of unknown function (DUF2568) - - - 0.0000000000000004969 83.0
TLS2_k127_7144712_5 von Willebrand factor (vWF) type A domain - - - 0.0000000000009216 80.0
TLS2_k127_7144712_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000005846 74.0
TLS2_k127_7144712_7 phosphinothricin N-acetyltransferase activity - - - 0.0000001141 63.0
TLS2_k127_7176509_0 PFAM pyruvate carboxyltransferase K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 311.0
TLS2_k127_7176509_1 PFAM Inosine uridine-preferring nucleoside hydrolase K01239 - 3.2.2.1 0.00000000000000000000000000000000000000000000000000002498 203.0
TLS2_k127_7176509_2 phosphorelay sensor kinase activity K16923,K18967 - 2.7.7.65 0.0000000000000002649 83.0
TLS2_k127_7229359_0 Coenzyme A transferase K01039 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 386.0
TLS2_k127_7229359_1 Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000003411 216.0
TLS2_k127_7229359_2 Iron-containing redox enzyme K06137 - 1.3.3.11 0.00000000001128 78.0
TLS2_k127_7229359_3 Multicopper oxidase K00368 - 1.7.2.1 0.000000001063 69.0
TLS2_k127_727319_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 2.781e-233 750.0
TLS2_k127_727319_1 cell division - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 342.0
TLS2_k127_727319_2 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 316.0
TLS2_k127_727319_3 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000001453 87.0
TLS2_k127_727319_4 Baseplate J-like protein K01218 - 3.2.1.78 0.000148 53.0
TLS2_k127_727319_5 Uncharacterised protein family (UPF0180) - - - 0.000376 50.0
TLS2_k127_7418075_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 8.368e-285 892.0
TLS2_k127_7418075_1 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000008273 115.0
TLS2_k127_7418075_2 PFAM TadE family protein - - - 0.000001143 59.0
TLS2_k127_7435465_0 PFAM Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 8.645e-209 666.0
TLS2_k127_7435465_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 617.0
TLS2_k127_7435465_10 COGs COG2343 conserved - - - 0.000000000000000000000000000000000005205 147.0
TLS2_k127_7435465_11 Rieske 2Fe-2S - - - 0.000000000000000000000000006419 117.0
TLS2_k127_7435465_12 GyrI-like small molecule binding domain - - - 0.0000000000000000000000002502 117.0
TLS2_k127_7435465_13 phospholipid glycerol acyltransferase - - - 0.000000009748 66.0
TLS2_k127_7435465_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004811 602.0
TLS2_k127_7435465_3 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 453.0
TLS2_k127_7435465_4 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 328.0
TLS2_k127_7435465_6 SMART ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001606 289.0
TLS2_k127_7435465_7 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000001269 181.0
TLS2_k127_7435465_8 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000009968 186.0
TLS2_k127_7435465_9 aminopeptidase N - - - 0.00000000000000000000000000000000000000000667 175.0
TLS2_k127_797979_0 Phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1281.0
TLS2_k127_797979_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K03737 - 1.2.7.1 8.981e-210 666.0
TLS2_k127_797979_10 Transcriptional K03892 - - 0.00000000000000001974 86.0
TLS2_k127_797979_11 Sulfurtransferase TusA - - - 0.00000000000000004032 89.0
TLS2_k127_797979_2 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 4.63e-207 661.0
TLS2_k127_797979_3 FAD-dependent pyridine nucleotide-disulfide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 440.0
TLS2_k127_797979_4 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 324.0
TLS2_k127_797979_5 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000001268 176.0
TLS2_k127_797979_6 Sulfurtransferase TusA - - - 0.00000000000000000000000002594 110.0
TLS2_k127_797979_7 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000003265 119.0
TLS2_k127_797979_8 Polysaccharide deacetylase - - - 0.000000000000000000002511 96.0
TLS2_k127_797979_9 signal transduction protein with CBS domains K07744 - - 0.00000000000000001386 91.0
TLS2_k127_800612_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 1.353e-303 949.0
TLS2_k127_800612_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.569e-287 900.0
TLS2_k127_800612_2 synthase K06044 - 5.4.99.15 1.311e-265 856.0
TLS2_k127_800612_3 4-alpha-glucanotransferase K00705 - 2.4.1.25 1.629e-201 646.0
TLS2_k127_800612_4 MreB/Mbl protein K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000811 456.0
TLS2_k127_800612_5 protein, probably involved in trehalose biosynthesis K16146 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.7.1.175 0.0000000000000000000176 93.0
TLS2_k127_800612_6 Involved in formation and maintenance of cell shape K03570 - - 0.00000006044 61.0
TLS2_k127_842208_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005521 594.0
TLS2_k127_842208_1 Belongs to the aldehyde dehydrogenase family K00130 - 1.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 505.0
TLS2_k127_842208_2 phosphinothricin N-acetyltransferase activity K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000000004633 203.0
TLS2_k127_842208_3 histidine kinase A domain protein K02484 - 2.7.13.3 0.0000000000000000000000000000000000000000009047 168.0
TLS2_k127_842208_4 type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis - - - 0.000000000000000000000000000000000002805 154.0
TLS2_k127_842208_5 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000005016 124.0
TLS2_k127_842208_6 Protein of unknown function (DUF1232) - - - 0.0000000000000009608 83.0
TLS2_k127_842208_7 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000002392 85.0
TLS2_k127_842208_8 von Willebrand factor (vWF) type A domain - - - 0.00000000003123 66.0
TLS2_k127_916850_0 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007128 291.0
TLS2_k127_916850_1 Protein of unknown function (DUF1461) - - - 0.000000000000374 76.0
TLS2_k127_963029_0 TIGRFAM DNA polymerase III, delta prime subunit K02341 - 2.7.7.7 0.00000000000000000000000000002388 132.0
TLS2_k127_963029_1 Acylphosphatase K01512 - 3.6.1.7 0.000000000000000003866 88.0
TLS2_k127_963029_2 Lipid kinase - - - 0.000000000322 71.0
TLS2_k127_987719_0 Cytochrome b(N-terminal)/b6/petB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007883 334.0
TLS2_k127_987719_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.00000000000000000000000000000000000000000000001598 178.0
TLS2_k127_987719_2 Rieske 2Fe-2S - - - 0.000000000000000000000000000000002006 144.0
TLS2_k127_987719_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0002418 49.0