Overview

ID MAG03997
Name TLS2_bin.30
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Actinomycetota
Class Acidimicrobiia
Order UBA5794
Family ZC4RG35
Genus JANQRA01
Species
Assembly information
Completeness (%) 73.02
Contamination (%) 4.23
GC content (%) 65.0
N50 (bp) 13,040
Genome size (bp) 2,991,687

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2882

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1018032_0 Belongs to the glycosyl hydrolase 3 family - - - 9.097e-301 942.0
TLS2_k127_1018032_1 Acyclic terpene utilisation family protein AtuA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 525.0
TLS2_k127_1018032_10 Phospholipase_D-nuclease N-terminal - - - 0.000000000000000000000000000000000002575 141.0
TLS2_k127_1018032_11 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000007865 68.0
TLS2_k127_1018032_2 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 444.0
TLS2_k127_1018032_3 Bacterial extracellular solute-binding protein K10117 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003364 415.0
TLS2_k127_1018032_4 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 345.0
TLS2_k127_1018032_5 Binding-protein-dependent transport system inner membrane component K10118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 336.0
TLS2_k127_1018032_6 Binding-protein-dependent transport system inner membrane component K02026,K10119,K17243 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 312.0
TLS2_k127_1018032_7 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005357 300.0
TLS2_k127_1018032_8 helix_turn _helix lactose operon repressor K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000427 229.0
TLS2_k127_1018032_9 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000009133 184.0
TLS2_k127_1041430_0 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009702 478.0
TLS2_k127_1041430_1 CAAX amino terminal protease family - - - 0.000000000000000000000000000000000000005238 156.0
TLS2_k127_1041430_2 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000001678 107.0
TLS2_k127_1041430_3 - - - - 0.000000000000000005637 96.0
TLS2_k127_1041430_4 Domain of unknown function (DUF1794) - - - 0.00004968 51.0
TLS2_k127_1047102_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000007167 151.0
TLS2_k127_1047102_1 Protein of unknown function (DUF2568) - - - 0.000000000000000003667 90.0
TLS2_k127_1047102_3 - - - - 0.000000000000008256 79.0
TLS2_k127_1047102_4 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000002243 66.0
TLS2_k127_1047169_0 Proline racemase K01777 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016855,GO:0018112,GO:0019752,GO:0036361,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0050346,GO:0071704,GO:1901564 5.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008995 420.0
TLS2_k127_1047169_1 Amino Acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 326.0
TLS2_k127_1047169_10 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide - - - 0.00000000000000000000000002296 113.0
TLS2_k127_1047169_11 GAF domain - - - 0.0000000000000000000000005618 121.0
TLS2_k127_1047169_12 AraC-like ligand binding domain - - - 0.000000000000000000001441 101.0
TLS2_k127_1047169_13 Zn-ribbon protein, possibly nucleic acid-binding K07164 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000001163 89.0
TLS2_k127_1047169_14 membrane-bound metal-dependent hydrolase - - - 0.0000000000000004115 85.0
TLS2_k127_1047169_15 - K22014 - - 0.00000000000006227 74.0
TLS2_k127_1047169_16 Domain of unknown function (DUF4440) - - - 0.0000000005971 63.0
TLS2_k127_1047169_17 PFAM AIG2 family protein - - - 0.000000003003 67.0
TLS2_k127_1047169_18 Thiol-disulfide isomerase and thioredoxins - - - 0.0002844 47.0
TLS2_k127_1047169_2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004086 286.0
TLS2_k127_1047169_3 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002716 289.0
TLS2_k127_1047169_4 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000000000001185 186.0
TLS2_k127_1047169_5 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000003018 165.0
TLS2_k127_1047169_6 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.0000000000000000000000000000000000000615 152.0
TLS2_k127_1047169_7 NIF3 (NGG1p interacting factor 3) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000002213 143.0
TLS2_k127_1047169_8 Bacterial-like globin K06886 - - 0.00000000000000000000000000000004912 129.0
TLS2_k127_1047169_9 - - - - 0.00000000000000000000000000008727 126.0
TLS2_k127_1054707_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.4.4.2 0.0 1212.0
TLS2_k127_1054707_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 433.0
TLS2_k127_1054707_2 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 434.0
TLS2_k127_1054707_3 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000552 349.0
TLS2_k127_1054707_4 Exonuclease K03546 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 350.0
TLS2_k127_1054707_5 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 319.0
TLS2_k127_1054707_6 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 291.0
TLS2_k127_1054707_7 COGs COG2380 conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000122 246.0
TLS2_k127_1054707_8 Flavin-nucleotide-binding protein K07005 - - 0.000000000000000000000000000000000000000000000000000000005497 211.0
TLS2_k127_1054707_9 Histidine kinase - - - 0.0000000000000000000000000000001144 138.0
TLS2_k127_1066851_0 ABC-type dipeptide transport system periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000007543 242.0
TLS2_k127_1066851_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000004407 220.0
TLS2_k127_1066851_2 AlkA N-terminal domain K13529 - 3.2.2.21 0.00000000000000000000000000000000000000000009827 169.0
TLS2_k127_1066851_3 Domain of unknown function (DUF1905) - - - 0.0000000000000000000000000000000000000000002297 167.0
TLS2_k127_1066851_4 Bacterial regulatory protein, arsR family - - - 0.0000000000000000000000000000001761 137.0
TLS2_k127_1066851_5 Transcriptional regulator - - - 0.000000000000000000000000003919 116.0
TLS2_k127_1066851_6 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000009793 112.0
TLS2_k127_1066851_7 - - - - 0.00000000001717 67.0
TLS2_k127_108827_0 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007131 479.0
TLS2_k127_108827_1 Enoyl-CoA hydratase carnithine racemase K01692 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000005027 258.0
TLS2_k127_108827_10 Winged helix DNA-binding domain K09927 - - 0.000000000000101 78.0
TLS2_k127_108827_11 Winged helix DNA-binding domain K09927 - - 0.000729 44.0
TLS2_k127_108827_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000001487 175.0
TLS2_k127_108827_4 Stage II sporulation E family protein - - - 0.00000000000000000000000000000000000000002429 160.0
TLS2_k127_108827_5 Winged helix DNA-binding domain K09927 - - 0.00000000000000000000000000003749 121.0
TLS2_k127_108827_6 antisigma factor binding K03090,K04749,K06378 - - 0.000000000000000000000003706 105.0
TLS2_k127_108827_8 Winged helix DNA-binding domain K09927 - - 0.00000000000000001401 89.0
TLS2_k127_1111762_0 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 421.0
TLS2_k127_1111762_1 Major facilitator superfamily K08225 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009533 354.0
TLS2_k127_1111762_2 HI0933-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008614 333.0
TLS2_k127_1111762_3 PFAM Aldehyde dehydrogenase family K00128,K00131,K00146,K00151,K10217 - 1.2.1.3,1.2.1.32,1.2.1.39,1.2.1.60,1.2.1.85,1.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 318.0
TLS2_k127_1111762_4 ABC-type sugar transport system, permease component K02026 - - 0.0000000000000000000000000000000000000000000000000000000312 218.0
TLS2_k127_1111762_5 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000007646 196.0
TLS2_k127_1111762_6 transmembrane transport K02025,K15771 - - 0.0000000000000000000000000000000000000000000001289 180.0
TLS2_k127_1111762_7 Extracellular solute-binding protein K02027 - - 0.0000000000000001281 93.0
TLS2_k127_1111762_8 protein, possibly involved in utilization of glycolate and propanediol - - - 0.000000000003296 72.0
TLS2_k127_1140995_0 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 370.0
TLS2_k127_1140995_1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0008150,GO:0040007 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007887 342.0
TLS2_k127_1140995_2 TIGRFAM stage V sporulation protein D K03587,K08384 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000501 313.0
TLS2_k127_1140995_3 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005987 297.0
TLS2_k127_1140995_4 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001699 267.0
TLS2_k127_1140995_5 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000001381 256.0
TLS2_k127_1140995_6 endonuclease - - - 0.0000000000000000000000000000000000000000000001597 171.0
TLS2_k127_1140995_7 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000001011 177.0
TLS2_k127_1140995_8 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.0000000000000000000000001198 111.0
TLS2_k127_1140995_9 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.0005911 49.0
TLS2_k127_1157856_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 2.918e-295 920.0
TLS2_k127_1157856_1 Domain of unknown function (DUF4118) K07646 - 2.7.13.3 1.012e-248 793.0
TLS2_k127_1157856_10 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000000000000000000004855 180.0
TLS2_k127_1157856_11 acetyltransferase - - - 0.0000000000000000000000000000000000000000002117 166.0
TLS2_k127_1157856_12 Aspartyl protease - - - 0.0000000000000000000000000000000001076 149.0
TLS2_k127_1157856_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000003768 126.0
TLS2_k127_1157856_14 alpha/beta hydrolase fold - - - 0.00000000000000000000004915 109.0
TLS2_k127_1157856_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 1.652e-209 666.0
TLS2_k127_1157856_3 Potassium uptake protein K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004017 564.0
TLS2_k127_1157856_4 domain protein K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 295.0
TLS2_k127_1157856_5 COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07667 GO:0008150,GO:0040007 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 284.0
TLS2_k127_1157856_6 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000167 262.0
TLS2_k127_1157856_7 Protein of unknown function (DUF998) - - - 0.00000000000000000000000000000000000000000000000000000000002687 213.0
TLS2_k127_1157856_8 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000001508 205.0
TLS2_k127_1157856_9 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000000000000000009954 189.0
TLS2_k127_1159165_0 PFAM major facilitator superfamily MFS_1 K08167 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 604.0
TLS2_k127_1159165_1 PFAM extracellular solute-binding protein family 1 K10232 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 420.0
TLS2_k127_1159165_10 - - - - 0.0000000000000000003272 91.0
TLS2_k127_1159165_11 ROK family - - - 0.00000000000000003365 87.0
TLS2_k127_1159165_2 PFAM Binding-protein-dependent transport system inner membrane component K10119,K10234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000663 359.0
TLS2_k127_1159165_3 PFAM glycoside hydrolase, family 3 domain protein K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 346.0
TLS2_k127_1159165_4 COG1175 ABC-type sugar transport systems permease components K10233 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 320.0
TLS2_k127_1159165_5 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 320.0
TLS2_k127_1159165_6 PFAM sugar isomerase (SIS) K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005553 283.0
TLS2_k127_1159165_7 zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001311 272.0
TLS2_k127_1159165_8 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000009666 206.0
TLS2_k127_1159165_9 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000001531 165.0
TLS2_k127_1183777_0 Belongs to the GcvT family - - - 0.0 1131.0
TLS2_k127_1183777_1 COG1410 Methionine synthase I cobalamin-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 431.0
TLS2_k127_1183777_2 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 363.0
TLS2_k127_1183777_3 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003434 263.0
TLS2_k127_1183777_4 Protein of unknown function (DUF1638) - - - 0.000000000000000000000000000000000000000000000000000000000000000000008523 242.0
TLS2_k127_1183777_5 Electron transfer flavoprotein FAD-binding domain - - - 0.00000001642 67.0
TLS2_k127_1203364_0 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006113 283.0
TLS2_k127_1203364_1 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001944 277.0
TLS2_k127_1203364_2 COG1525 Micrococcal nuclease (thermonuclease) homologs K01174 - 3.1.31.1 0.00000000000000000000000000000000000001872 158.0
TLS2_k127_1203364_3 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000009284 139.0
TLS2_k127_1203364_4 D-alanyl-D-alanine carboxypeptidase - - - 0.00000000000000000000000000000467 133.0
TLS2_k127_1203364_5 Fasciclin - GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043207,GO:0044403,GO:0044419,GO:0044421,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071944,GO:0075136 - 0.000000000000000000000000008502 119.0
TLS2_k127_1203364_6 ECF sigma factor K03088 - - 0.000000000000000000000009416 108.0
TLS2_k127_1203364_7 protein import K01179 - 3.2.1.4 0.000005545 57.0
TLS2_k127_1216074_0 COG1404 Subtilisin-like serine proteases K14645 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 535.0
TLS2_k127_1216074_1 Epoxide hydrolase N terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 492.0
TLS2_k127_1216074_10 Contains one ATP-binding region, ATPase-like domain (IPR003594) - - - 0.000000000000000000000000000000000000000000000007613 186.0
TLS2_k127_1216074_11 chromate resistance protein - - - 0.000000000000000000000000000000000000000000009231 166.0
TLS2_k127_1216074_12 Toxic component of a toxin-antitoxin (TA) module K07171 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.0000000000000000000000000000000000000001642 152.0
TLS2_k127_1216074_13 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000009904 151.0
TLS2_k127_1216074_14 addiction module antidote protein, CC2985 family - GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351 - 0.0000000000000000000003616 97.0
TLS2_k127_1216074_15 - K07341 - - 0.00000000000000000001348 94.0
TLS2_k127_1216074_16 Low molecular weight phosphatase family - - - 0.000000005482 62.0
TLS2_k127_1216074_17 - K07341 - - 0.0000001994 54.0
TLS2_k127_1216074_18 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0004758 52.0
TLS2_k127_1216074_2 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 465.0
TLS2_k127_1216074_3 Serine aminopeptidase, S33 K00433 - 1.11.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 389.0
TLS2_k127_1216074_4 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304,K12267 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008113,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0016491,GO:0016667,GO:0016671,GO:0020012,GO:0030682,GO:0033744,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0075136 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 323.0
TLS2_k127_1216074_5 PFAM oxidoreductase, molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 291.0
TLS2_k127_1216074_6 epimerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005745 295.0
TLS2_k127_1216074_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003887 288.0
TLS2_k127_1216074_8 Belongs to the Pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000654 220.0
TLS2_k127_1216074_9 Host cell surface-exposed lipoprotein - - - 0.0000000000000000000000000000000000000000000000001087 190.0
TLS2_k127_1232735_0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009601 608.0
TLS2_k127_1232735_1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008131 461.0
TLS2_k127_1232735_2 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000000000000000000002856 159.0
TLS2_k127_1232735_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000004074 86.0
TLS2_k127_1232914_0 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 457.0
TLS2_k127_1232914_1 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 436.0
TLS2_k127_1232914_2 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000003613 263.0
TLS2_k127_1232914_3 PAC2 family - - - 0.00000000000000000000000000000000000000000000000000000000006955 214.0
TLS2_k127_1232914_4 Permease K20469 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000000000000000000000000000000000000000000004245 196.0
TLS2_k127_1232914_5 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.0000000000000000000000000000000000000001635 160.0
TLS2_k127_1232914_6 Single-strand binding protein family K03111 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000008195 146.0
TLS2_k127_1232914_7 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000002918 136.0
TLS2_k127_1232914_8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000001078 91.0
TLS2_k127_1232914_9 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000001539 78.0
TLS2_k127_1277001_0 PFAM sodium hydrogen exchanger - - - 6.308e-211 677.0
TLS2_k127_1277001_1 ketone body catabolic process K01026 - 2.8.3.1 1.472e-209 664.0
TLS2_k127_1277001_10 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 426.0
TLS2_k127_1277001_11 Anthranilate synthase component I, N terminal region K01657,K13503 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 375.0
TLS2_k127_1277001_12 DAHP synthetase I family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 358.0
TLS2_k127_1277001_13 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000097 369.0
TLS2_k127_1277001_14 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 342.0
TLS2_k127_1277001_15 Periplasmic binding protein domain K02058,K10439,K17213 GO:0003674,GO:0005215,GO:0005488,GO:0005534,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0015144,GO:0015145,GO:0015749,GO:0015757,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006097 330.0
TLS2_k127_1277001_16 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 329.0
TLS2_k127_1277001_17 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002843 315.0
TLS2_k127_1277001_18 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000001411 245.0
TLS2_k127_1277001_19 Phosphotriesterase family K07048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004086 257.0
TLS2_k127_1277001_2 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 615.0
TLS2_k127_1277001_20 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000005442 248.0
TLS2_k127_1277001_21 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000008726 235.0
TLS2_k127_1277001_22 Periplasmic binding protein LacI transcriptional regulator K02529 - - 0.000000000000000000000000000000000000000000000000000000000000002223 232.0
TLS2_k127_1277001_23 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000002051 194.0
TLS2_k127_1277001_24 Belongs to the TrpC family K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.000000000000000000000000000000000000000000000006364 183.0
TLS2_k127_1277001_25 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 0.000000000000000000000000000000000000000003778 164.0
TLS2_k127_1277001_26 Sigma-70 region 2 - - - 0.000000000000000000000000000000000000000009111 160.0
TLS2_k127_1277001_27 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000001714 138.0
TLS2_k127_1277001_28 Belongs to the pirin family K06911 - - 0.00000000000000000000000000001363 119.0
TLS2_k127_1277001_29 - - - - 0.000000000000000000000005872 106.0
TLS2_k127_1277001_3 ABC-type sugar transport system, ATPase component K10441 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 582.0
TLS2_k127_1277001_30 Subtilase family - - - 0.0000005727 62.0
TLS2_k127_1277001_31 Luciferase-like monooxygenase - - - 0.000006897 51.0
TLS2_k127_1277001_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 569.0
TLS2_k127_1277001_5 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 571.0
TLS2_k127_1277001_6 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 445.0
TLS2_k127_1277001_7 AP endonuclease family 2 C terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 438.0
TLS2_k127_1277001_8 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 428.0
TLS2_k127_1277001_9 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005656 430.0
TLS2_k127_1283903_0 Electron transfer flavoprotein K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001918 288.0
TLS2_k127_1283903_1 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000000000000000006457 185.0
TLS2_k127_1283903_2 molybdopterin cofactor binding - - - 0.0000000000000000000000000000000000004231 162.0
TLS2_k127_1283903_3 nuclease activity K18828 - - 0.0000000000000000000000001232 113.0
TLS2_k127_1283903_4 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000001618 90.0
TLS2_k127_1283903_5 S-layer homology domain - - - 0.000000001884 71.0
TLS2_k127_1283903_6 - - - - 0.000000002213 61.0
TLS2_k127_1283903_7 Belongs to the glycosyl hydrolase 31 family K20844 - 3.2.1.55 0.00000001304 68.0
TLS2_k127_1323919_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 2.547e-202 639.0
TLS2_k127_1323919_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 570.0
TLS2_k127_1323919_2 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 533.0
TLS2_k127_1323919_3 Peptidase family M20/M25/M40 K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 301.0
TLS2_k127_1323919_4 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000002937 250.0
TLS2_k127_1323919_5 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.0000000000000000000000000000000000001169 155.0
TLS2_k127_1323919_6 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944 - 0.00000000000000000000000009598 119.0
TLS2_k127_1323919_7 Methyltransferase domain - - - 0.000000000002768 77.0
TLS2_k127_1337253_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 406.0
TLS2_k127_1337253_1 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 323.0
TLS2_k127_1337253_10 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.000006003 57.0
TLS2_k127_1337253_11 Belongs to the 'phage' integrase family - - - 0.0004362 43.0
TLS2_k127_1337253_2 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 318.0
TLS2_k127_1337253_3 DNA polymerase LigD, polymerase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000658 241.0
TLS2_k127_1337253_4 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000001223 187.0
TLS2_k127_1337253_5 endoribonuclease L-PSP - - - 0.00000000000000000000000000000002954 128.0
TLS2_k127_1337253_6 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.0000000000000000000000000000002824 134.0
TLS2_k127_1337253_7 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000000002068 112.0
TLS2_k127_1337253_8 Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine - - - 0.000000000000000000001196 103.0
TLS2_k127_1337253_9 Virulence factor BrkB - - - 0.0000000003787 71.0
TLS2_k127_1380861_0 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000000002814 175.0
TLS2_k127_1380861_1 Protein of unknown function (DUF998) - - - 0.00000000000000000000000000000000000000006971 159.0
TLS2_k127_1380861_2 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000001778 143.0
TLS2_k127_1380861_3 Sucrose-6F-phosphate phosphohydrolase - - - 0.0001562 45.0
TLS2_k127_1385517_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 473.0
TLS2_k127_1385517_1 Stage II sporulation E family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 468.0
TLS2_k127_1385517_2 Peptidase family S58 K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007812 411.0
TLS2_k127_1385517_3 Transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004682 415.0
TLS2_k127_1385517_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000002777 185.0
TLS2_k127_1385517_5 Histidine kinase - - - 0.00000000000000000000000000000000288 145.0
TLS2_k127_1385517_6 polyketide cyclase - - - 0.00000000000000000000000000001273 125.0
TLS2_k127_1385517_7 Histidine kinase - - - 0.0005303 44.0
TLS2_k127_1439315_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 552.0
TLS2_k127_1439315_1 phosphatidate phosphatase activity - - - 0.000000000000000008327 92.0
TLS2_k127_1474623_0 Bacterial low temperature requirement A protein (LtrA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002786 274.0
TLS2_k127_1474623_1 Adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000005834 83.0
TLS2_k127_151522_0 TrkA-C domain - - - 8.401e-249 790.0
TLS2_k127_151522_1 Dehydrogenase K00140 - 1.2.1.18,1.2.1.27 3.967e-210 665.0
TLS2_k127_151522_2 Histidine kinase K07636 - 2.7.13.3 0.0000000000000000000000000000003976 138.0
TLS2_k127_151522_3 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000006932 129.0
TLS2_k127_151522_4 Transcriptional regulator - - - 0.000000000000000000000000000002366 128.0
TLS2_k127_151522_5 regulator of chromosome condensation, RCC1 K12287 - - 0.000005302 58.0
TLS2_k127_1556818_0 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005511 598.0
TLS2_k127_1556818_1 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006486 533.0
TLS2_k127_1556818_10 Cation transport protein K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 404.0
TLS2_k127_1556818_11 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 374.0
TLS2_k127_1556818_12 AAA domain (Cdc48 subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 355.0
TLS2_k127_1556818_13 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007644 348.0
TLS2_k127_1556818_14 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 349.0
TLS2_k127_1556818_15 ABC transporter K10545 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 339.0
TLS2_k127_1556818_16 Branched-chain amino acid transport system permease K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 335.0
TLS2_k127_1556818_17 Oxidoreductase FAD-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 299.0
TLS2_k127_1556818_18 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006152 298.0
TLS2_k127_1556818_19 ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005407 295.0
TLS2_k127_1556818_2 Belongs to the binding-protein-dependent transport system permease family K10544 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 507.0
TLS2_k127_1556818_20 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995,K11957 GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001001 282.0
TLS2_k127_1556818_21 branched-chain amino acid transmembrane transporter activity K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001422 281.0
TLS2_k127_1556818_22 Oxidoreductase molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002847 277.0
TLS2_k127_1556818_23 TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003855 286.0
TLS2_k127_1556818_24 electron transport chain K00347,K03614,K21163 - 1.6.5.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004873 295.0
TLS2_k127_1556818_25 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001585 277.0
TLS2_k127_1556818_26 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000009576 225.0
TLS2_k127_1556818_27 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000002301 226.0
TLS2_k127_1556818_28 Periplasmic binding protein LacI transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000001519 220.0
TLS2_k127_1556818_29 2OG-Fe(II) oxygenase superfamily - - - 0.000000000000000000000000000000000000000000002717 183.0
TLS2_k127_1556818_3 Xaa-Pro aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 484.0
TLS2_k127_1556818_30 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 0.000000000000000000000000000000000000000006282 163.0
TLS2_k127_1556818_31 Cation efflux family - - - 0.0000000000000000000000000000000000000006073 156.0
TLS2_k127_1556818_32 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000004881 119.0
TLS2_k127_1556818_33 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000006437 117.0
TLS2_k127_1556818_34 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000006901 119.0
TLS2_k127_1556818_35 cheY-homologous receiver domain - - - 0.0000000000000000000000004165 109.0
TLS2_k127_1556818_36 - - - - 0.000000000000976 71.0
TLS2_k127_1556818_37 peptidase - - - 0.00002658 55.0
TLS2_k127_1556818_4 Ribonuclease E/G family K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 472.0
TLS2_k127_1556818_5 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003664 459.0
TLS2_k127_1556818_6 VWA domain containing CoxE-like protein K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 447.0
TLS2_k127_1556818_7 Periplasmic binding protein domain K10543 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 432.0
TLS2_k127_1556818_8 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 434.0
TLS2_k127_1556818_9 Belongs to the xylose isomerase family K01805 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 417.0
TLS2_k127_1598539_0 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 375.0
TLS2_k127_1598539_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 370.0
TLS2_k127_1598539_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 340.0
TLS2_k127_1598539_3 Glycosyl transferase, family 2 K00721,K01912,K08301 - 2.4.1.83,6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000005483 241.0
TLS2_k127_1598539_4 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000002784 81.0
TLS2_k127_1598539_5 - - - - 0.000000000004256 79.0
TLS2_k127_1598539_6 - - - - 0.000000000288 72.0
TLS2_k127_166020_0 DALR_2 K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 450.0
TLS2_k127_166020_1 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000004679 235.0
TLS2_k127_166020_2 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.000000000000000000000000000000000000000000287 164.0
TLS2_k127_166020_3 RNA 2'-O ribose methyltransferase substrate binding K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000003704 166.0
TLS2_k127_1696477_0 Belongs to the GPAT DAPAT family K00631 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 453.0
TLS2_k127_1696477_1 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009863 374.0
TLS2_k127_1696477_2 ABC-type multidrug transport system, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009566 298.0
TLS2_k127_1696477_3 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002819 282.0
TLS2_k127_1696477_4 Belongs to the helicase family. UvrD subfamily K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000007539 193.0
TLS2_k127_1696477_5 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.0000000000000000000000000000000000000000000001547 176.0
TLS2_k127_1696477_6 transcriptional - - - 0.0000000000000000000000000000000121 133.0
TLS2_k127_1696477_7 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000533 99.0
TLS2_k127_1802142_0 ATPase with chaperone activity K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002763 396.0
TLS2_k127_1802142_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K02405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000101 287.0
TLS2_k127_1802142_10 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.0000000000000000000000000000000000000004703 153.0
TLS2_k127_1802142_11 Nitrogen regulatory protein P-II K04751,K04752 - - 0.0000000000000000000000000000000000000006941 150.0
TLS2_k127_1802142_2 gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 296.0
TLS2_k127_1802142_3 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008918 287.0
TLS2_k127_1802142_4 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000355 293.0
TLS2_k127_1802142_5 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000001266 229.0
TLS2_k127_1802142_6 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000004287 224.0
TLS2_k127_1802142_7 MafB19-like deaminase - - - 0.0000000000000000000000000000000000000000000000000000000023 211.0
TLS2_k127_1802142_8 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000001061 186.0
TLS2_k127_1802142_9 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.000000000000000000000000000000000000000000000001223 187.0
TLS2_k127_1890358_0 Thiolase, C-terminal domain K00626,K02615 - 2.3.1.174,2.3.1.223,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 476.0
TLS2_k127_1890358_1 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000005489 276.0
TLS2_k127_1890358_2 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004656 274.0
TLS2_k127_1890358_3 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000183 206.0
TLS2_k127_1890358_4 HhH-GPD superfamily base excision DNA repair protein - - - 0.00000000000000000000000000000000000000000000000000003737 194.0
TLS2_k127_1890358_5 Thioesterase - - - 0.0000000000000000000000000842 118.0
TLS2_k127_1890358_6 - - - - 0.000000002822 67.0
TLS2_k127_1896374_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 GO:0005575,GO:0005576,GO:0008150,GO:0040007 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008903 520.0
TLS2_k127_1896374_1 Ferredoxin-fold anticodon binding domain K01890 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004326 519.0
TLS2_k127_1896374_10 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000001221 126.0
TLS2_k127_1896374_11 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.00000000000000000000000002085 118.0
TLS2_k127_1896374_12 - - - - 0.0000000000000000000000003989 106.0
TLS2_k127_1896374_13 - - - - 0.000000000000000000000002197 103.0
TLS2_k127_1896374_14 - - - - 0.000000000000003439 80.0
TLS2_k127_1896374_15 structural constituent of ribosome K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000001523 69.0
TLS2_k127_1896374_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 390.0
TLS2_k127_1896374_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 342.0
TLS2_k127_1896374_4 riboflavin synthase, alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000007703 215.0
TLS2_k127_1896374_5 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000002395 218.0
TLS2_k127_1896374_6 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.000000000000000000000000000000000000000000000000000005133 197.0
TLS2_k127_1896374_7 Belongs to the DNA glycosylase MPG family K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.000000000000000000000000000000000000000000000003267 178.0
TLS2_k127_1896374_8 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000003564 154.0
TLS2_k127_1896374_9 - - - - 0.000000000000000000000000000000000000002458 149.0
TLS2_k127_1896871_0 Evidence 5 No homology to any previously reported sequences - - - 1.167e-261 827.0
TLS2_k127_1896871_1 ABC-type branched-chain amino acid transport systems, periplasmic component K01999,K07407 - 3.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 590.0
TLS2_k127_1896871_10 chorismate binding enzyme K02361,K02552 - 5.4.4.2 0.000000000000000000000000000000000000000000000002946 184.0
TLS2_k127_1896871_11 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059,K03793 - 1.1.1.100,1.5.1.33 0.000000000000000000000000000000000000007722 154.0
TLS2_k127_1896871_2 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K05555 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000475 449.0
TLS2_k127_1896871_3 L-phenylalanine transmembrane transporter activity K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007696 447.0
TLS2_k127_1896871_4 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 368.0
TLS2_k127_1896871_5 Short-chain dehydrogenase reductase sdr K00046 - 1.1.1.69 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 317.0
TLS2_k127_1896871_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 290.0
TLS2_k127_1896871_7 branched-chain amino acid transmembrane transporter activity K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007442 262.0
TLS2_k127_1896871_8 PFAM ThiJ PfpI - - - 0.0000000000000000000000000000000000000000000000000000000000000000000227 239.0
TLS2_k127_1896871_9 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000006118 190.0
TLS2_k127_1910108_0 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000002873 241.0
TLS2_k127_1910108_1 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.00000000000000000000000000000000000000000000000000000001691 208.0
TLS2_k127_1910108_2 Thiol-disulfide isomerase-like thioredoxin K02199 - - 0.0000000000000000000000000000000000000000000000000004257 191.0
TLS2_k127_1910108_3 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000000000405 160.0
TLS2_k127_1910108_4 subunit of a heme lyase K02200 - - 0.00000000000000000197 97.0
TLS2_k127_1910108_5 Domain of unknown function (DUF4440) - - - 0.00000000000000003544 83.0
TLS2_k127_1910108_6 HNH nucleases - - - 0.0000000000000004189 86.0
TLS2_k127_1910108_8 HNH endonuclease - - - 0.000001052 57.0
TLS2_k127_1950457_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 5.444e-217 679.0
TLS2_k127_1950457_1 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit K00341 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 523.0
TLS2_k127_1950457_2 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 516.0
TLS2_k127_1950457_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006427 435.0
TLS2_k127_1950457_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 308.0
TLS2_k127_1950457_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000002793 119.0
TLS2_k127_1950457_6 Domain protein associated with RNAses G and E K07586 - - 0.00000000000000000000000000004224 124.0
TLS2_k127_1950457_7 Polymer-forming cytoskeletal - - - 0.000000000003948 78.0
TLS2_k127_1955924_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 1.463e-235 740.0
TLS2_k127_1955924_1 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 348.0
TLS2_k127_1955924_2 GCN5 family acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004974 245.0
TLS2_k127_1955924_3 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000003768 224.0
TLS2_k127_1955924_4 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000006182 162.0
TLS2_k127_1955924_5 Alpha beta hydrolase - - - 0.00000000000000000000000000000001643 129.0
TLS2_k127_1955924_6 Acetyltransferase (GNAT) family - - - 0.0000000000001282 79.0
TLS2_k127_1999720_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004285 606.0
TLS2_k127_1999720_1 Alpha amylase catalytic K01187,K05343 - 3.2.1.1,3.2.1.20,5.4.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 584.0
TLS2_k127_1999720_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 490.0
TLS2_k127_1999720_3 Glycosyltransferase family 20 K00697,K16055 GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 494.0
TLS2_k127_1999720_4 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 340.0
TLS2_k127_1999720_5 PFAM isochorismatase hydrolase K08281 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000005618 222.0
TLS2_k127_1999720_6 Glycosyl hydrolases family 15 K01087 - 3.1.3.12 0.0000000000000000000000000000000000001095 154.0
TLS2_k127_1999720_7 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000776 138.0
TLS2_k127_1999720_8 PFAM PspC domain - - - 0.000000000000000000000000001352 126.0
TLS2_k127_1999720_9 PspC domain - - - 0.00000001159 64.0
TLS2_k127_1999750_0 PFAM aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 1.308e-202 660.0
TLS2_k127_1999750_1 Adenylyl cyclase class-3 4 guanylyl cyclase - - - 1.739e-196 658.0
TLS2_k127_1999750_10 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001698 271.0
TLS2_k127_1999750_11 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001439 254.0
TLS2_k127_1999750_12 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001603 253.0
TLS2_k127_1999750_13 PFAM isochorismatase hydrolase K08281 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 0.00000000000000000000000000000000000000000000000000000000000002713 220.0
TLS2_k127_1999750_14 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000128 159.0
TLS2_k127_1999750_15 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000001656 140.0
TLS2_k127_1999750_16 Sodium/hydrogen exchanger family K03316 - - 0.00000000000000000000000000002181 121.0
TLS2_k127_1999750_17 PAS domain - - - 0.00000000000000000000004705 104.0
TLS2_k127_1999750_18 GCN5-related N-acetyl-transferase K06975 - - 0.00000000000000000000004784 106.0
TLS2_k127_1999750_19 lactoylglutathione lyase activity - - - 0.00000000000000000182 91.0
TLS2_k127_1999750_2 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 604.0
TLS2_k127_1999750_20 PspC domain - - - 0.00000000000000002094 95.0
TLS2_k127_1999750_21 Histidine kinase - - - 0.00000000344 65.0
TLS2_k127_1999750_3 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 596.0
TLS2_k127_1999750_4 Alpha amylase catalytic K01187,K05343 - 3.2.1.1,3.2.1.20,5.4.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 582.0
TLS2_k127_1999750_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 498.0
TLS2_k127_1999750_6 Glycosyltransferase family 20 K00697,K16055 GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 496.0
TLS2_k127_1999750_7 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 427.0
TLS2_k127_1999750_8 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 345.0
TLS2_k127_1999750_9 Bacterial low temperature requirement A protein (LtrA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002157 274.0
TLS2_k127_2020781_0 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 2.503e-291 900.0
TLS2_k127_2020781_1 ABC-type proline glycine betaine transport system permease component K02001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 407.0
TLS2_k127_2020781_2 glycine betaine K02000 - 3.6.3.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 376.0
TLS2_k127_2042674_0 Kynurenine--oxoglutarate transaminase - GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 450.0
TLS2_k127_2042674_1 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 363.0
TLS2_k127_2042674_2 transport, permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000003523 232.0
TLS2_k127_2042674_3 F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000001235 187.0
TLS2_k127_2042674_4 F420H(2)-dependent quinone reductase - - - 0.0000000000000000000000000000000001959 138.0
TLS2_k127_2042674_5 Belongs to the universal stress protein A family - - - 0.000000001017 70.0
TLS2_k127_2042674_6 PFAM aldo keto reductase K19265 - - 0.0000008879 56.0
TLS2_k127_2063650_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.3.4.2 1.759e-215 690.0
TLS2_k127_2063650_1 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K13571 GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 7.003e-211 662.0
TLS2_k127_2063650_10 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000004559 187.0
TLS2_k127_2063650_11 Haloacid dehalogenase-like hydrolase K01101 - 3.1.3.41 0.000000000000000000000000000000000000000000000009975 193.0
TLS2_k127_2063650_12 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000003759 164.0
TLS2_k127_2063650_13 transcriptional regulator K13572,K13573 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000004308 164.0
TLS2_k127_2063650_14 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.00000000000000000000000000000000000001254 154.0
TLS2_k127_2063650_15 SMART diacylglycerol kinase catalytic region K07029 - 2.7.1.107 0.0000000000000000000000000003498 125.0
TLS2_k127_2063650_16 PFAM NUDIX hydrolase K01515,K03574 - 3.6.1.13,3.6.1.55 0.000000000000000000000000006594 118.0
TLS2_k127_2063650_17 Acetyltransferase (GNAT) family - - - 0.000000001038 70.0
TLS2_k127_2063650_18 - - - - 0.000000002736 63.0
TLS2_k127_2063650_19 Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation K13570 - - 0.0000000393 58.0
TLS2_k127_2063650_2 DSHCT K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 6.333e-199 649.0
TLS2_k127_2063650_20 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000007287 60.0
TLS2_k127_2063650_21 Domain of unknown function (DUF4193) - - - 0.000336 52.0
TLS2_k127_2063650_3 Pup-ligase protein K20814 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 469.0
TLS2_k127_2063650_4 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 360.0
TLS2_k127_2063650_5 May be involved in recombinational repair of damaged DNA K03631 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006572 299.0
TLS2_k127_2063650_6 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000287 268.0
TLS2_k127_2063650_7 Proteasome subunit K03433 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001659 256.0
TLS2_k127_2063650_8 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000001768 245.0
TLS2_k127_2063650_9 transcriptional regulator K13573 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000006204 197.0
TLS2_k127_2067982_0 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 533.0
TLS2_k127_2067982_1 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004554 296.0
TLS2_k127_2067982_10 - - - - 0.00000000000000000000000001162 115.0
TLS2_k127_2067982_11 Fic/DOC family K07341 - - 0.000000000000008112 78.0
TLS2_k127_2067982_12 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000001109 71.0
TLS2_k127_2067982_14 Fic/DOC family K07341 - - 0.0002743 47.0
TLS2_k127_2067982_15 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0004207 45.0
TLS2_k127_2067982_2 helix_turn_helix, Lux Regulon K07693 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001234 272.0
TLS2_k127_2067982_3 triphosphatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001063 251.0
TLS2_k127_2067982_4 F420H(2)-dependent quinone reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001702 235.0
TLS2_k127_2067982_5 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000005264 235.0
TLS2_k127_2067982_6 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000007242 214.0
TLS2_k127_2067982_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07778 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000006818 225.0
TLS2_k127_2067982_8 COG1012 NAD-dependent aldehyde dehydrogenases K13922,K15515 - 1.2.1.81,1.2.1.87 0.00000000000000000000000000000000000000000000000002405 183.0
TLS2_k127_2067982_9 Major facilitator Superfamily - - - 0.000000000000000000000000000000007805 145.0
TLS2_k127_2091854_0 Ftsk_gamma K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 574.0
TLS2_k127_2091854_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006136 463.0
TLS2_k127_2091854_2 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004883 390.0
TLS2_k127_2091854_3 Dehydrogenase E1 component K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 313.0
TLS2_k127_2091854_4 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009735 288.0
TLS2_k127_20990_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 3.782e-233 730.0
TLS2_k127_20990_1 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - 0.00000000000000000000000000000000000000000000000002359 186.0
TLS2_k127_20990_2 Formamidopyrimidine-DNA glycosylase N-terminal domain K05522 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.0000000000000000000000000000000000000000000345 170.0
TLS2_k127_20990_3 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000002844 175.0
TLS2_k127_20990_4 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000003499 165.0
TLS2_k127_20990_5 Thioesterase superfamily protein - - - 0.000000000000000000000000000000001814 134.0
TLS2_k127_20990_6 - - - - 0.00000000000001015 86.0
TLS2_k127_2130409_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 1.592e-271 846.0
TLS2_k127_2130409_1 Monooxygenase K14733 - 1.14.13.107 0.000000000000000000000000000000000000000000000000000000000000000000000001134 259.0
TLS2_k127_2130409_10 DinB superfamily - - - 0.0008502 49.0
TLS2_k127_2130409_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000007571 237.0
TLS2_k127_2130409_3 Thioredoxin K00384,K03671,K03672 - 1.8.1.8,1.8.1.9 0.0000000000000000000000000000000000000000000000004146 178.0
TLS2_k127_2130409_4 Acetyltransferase (GNAT) domain K03829 - - 0.00000000000000000000000000000000000000000000005164 173.0
TLS2_k127_2130409_5 YbaK prolyl-tRNA synthetase associated region - - - 0.00000000000000000000000000000000000000000000555 168.0
TLS2_k127_2130409_6 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.0000000000000000000000000000000000000000009826 165.0
TLS2_k127_2130409_7 Tetratricopeptide repeat - - - 0.00000000000001346 80.0
TLS2_k127_2130409_8 DinB superfamily - - - 0.00000000000005675 74.0
TLS2_k127_2130409_9 Single-stranded DNA-binding protein K03111 - - 0.000008454 53.0
TLS2_k127_21322_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 9.021e-276 881.0
TLS2_k127_21322_1 Belongs to the GPI family K01810 - 5.3.1.9 3.392e-220 694.0
TLS2_k127_21322_10 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000944 237.0
TLS2_k127_21322_11 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000001762 182.0
TLS2_k127_21322_12 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000003643 179.0
TLS2_k127_21322_13 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000009202 148.0
TLS2_k127_21322_14 o-methyltransferase - - - 0.00000000000000000000000000000000919 133.0
TLS2_k127_21322_15 Disulfide bond formation protein DsbB K03611 - - 0.0000000000000000000000000000000363 132.0
TLS2_k127_21322_16 Redoxin - - - 0.000000000000000000000000000009584 129.0
TLS2_k127_21322_17 - - - - 0.000000000000000000000000009617 115.0
TLS2_k127_21322_18 NifU-like domain - - - 0.0000000000000000007769 90.0
TLS2_k127_21322_19 Domain of unknown function (DUF4440) - - - 0.000000000000002486 81.0
TLS2_k127_21322_2 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 507.0
TLS2_k127_21322_21 Nucleotidyltransferase domain K07075 - - 0.000000006388 61.0
TLS2_k127_21322_22 response to heat K03668,K09914 - - 0.0000006973 59.0
TLS2_k127_21322_23 - - - - 0.00001274 51.0
TLS2_k127_21322_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K00446 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005534 488.0
TLS2_k127_21322_4 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 GO:0008150,GO:0040007 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 432.0
TLS2_k127_21322_5 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 399.0
TLS2_k127_21322_6 EamA-like transporter family K11939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 319.0
TLS2_k127_21322_7 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003131 296.0
TLS2_k127_21322_8 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000005113 248.0
TLS2_k127_21322_9 AMP-binding enzyme C-terminal domain K01911 - 6.2.1.26 0.00000000000000000000000000000000000000000000000000000000000000000001861 248.0
TLS2_k127_2135257_0 ATPase P-type (Transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 484.0
TLS2_k127_2135257_1 Belongs to the HAD-like hydrolase superfamily K02566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 374.0
TLS2_k127_2135257_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K15553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 378.0
TLS2_k127_2135257_3 Binding-protein-dependent transport system inner membrane component K15554 - - 0.0000000000000000000000000000000000000000007639 162.0
TLS2_k127_2135257_4 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.00000005758 61.0
TLS2_k127_220422_0 Acyl-CoA dehydrogenase N terminal - - - 4.529e-218 691.0
TLS2_k127_220422_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 453.0
TLS2_k127_220422_10 YbaK prolyl-tRNA synthetase associated - - - 0.00000000000000000000000000000000001198 140.0
TLS2_k127_220422_11 hydrolase of the alpha beta superfamily K07018 - - 0.0000000000000000000000537 107.0
TLS2_k127_220422_12 Bacterial regulatory proteins, tetR family K22108 GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0042803,GO:0046983,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000002466 57.0
TLS2_k127_220422_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004241 418.0
TLS2_k127_220422_3 e3 binding domain K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 362.0
TLS2_k127_220422_4 Elongator protein 3, MiaB family, Radical SAM K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006011 345.0
TLS2_k127_220422_5 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 325.0
TLS2_k127_220422_6 FeS assembly ATPase SufC K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 293.0
TLS2_k127_220422_7 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.000000000000000000000000000000000000000000000000000000000008098 218.0
TLS2_k127_220422_8 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000001872 169.0
TLS2_k127_220422_9 F420-dependent oxidoreductase K04091 - 1.14.14.5 0.000000000000000000000000000000000002031 153.0
TLS2_k127_2213508_0 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K09972,K10041 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 419.0
TLS2_k127_2213508_1 beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 434.0
TLS2_k127_2213508_2 enzyme of poly-gamma-glutamate biosynthesis (Capsule formation) K07282 - - 0.000000000000000000000000000000000000000003548 173.0
TLS2_k127_221832_0 Cell shape determining protein MreB Mrl K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008525 471.0
TLS2_k127_221832_1 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000004312 282.0
TLS2_k127_221832_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004142 254.0
TLS2_k127_221832_3 PFAM Thymidine kinase K00857 - 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000003638 225.0
TLS2_k127_221832_4 Involved in formation and maintenance of cell shape K03570 - - 0.0000000002324 71.0
TLS2_k127_2253819_0 Domain of Unknown Function (DUF1206) - - - 0.0000000000000000000000000000000000000000000000000000000000000002406 229.0
TLS2_k127_2253819_1 Transposase (IS116 IS110 IS902 family) - - - 0.000000000000000000000000000000000000000000000000000000000002389 214.0
TLS2_k127_2253819_2 Transposase (IS116 IS110 IS902 family) - - - 0.00000000000000000000000000006085 122.0
TLS2_k127_2253819_3 GDP-mannose mannosyl hydrolase activity K03574 - 3.6.1.55 0.0000000000000000000000000007168 119.0
TLS2_k127_2253819_4 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000001953 108.0
TLS2_k127_2253819_5 Transposase - - - 0.0000000000000008836 79.0
TLS2_k127_2253819_7 Bacterial regulatory proteins, tetR family - - - 0.000000000001752 68.0
TLS2_k127_2258979_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006181 572.0
TLS2_k127_2258979_1 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 480.0
TLS2_k127_2258979_10 Universal stress protein family - - - 0.0000000000000000000000000000006591 127.0
TLS2_k127_2258979_11 Histidine kinase - - - 0.000000000000000000000000000005237 137.0
TLS2_k127_2258979_12 molybdopterin cofactor binding - - - 0.000000000000000000000000295 123.0
TLS2_k127_2258979_13 HAMP domain - - - 0.00000000000000000000009245 110.0
TLS2_k127_2258979_14 Protein of unknown function (DUF2905) - - - 0.000000000000000003016 86.0
TLS2_k127_2258979_15 Evidence 5 No homology to any previously reported sequences - - - 0.000000000009242 79.0
TLS2_k127_2258979_16 Protein of unknown function (DUF3039) - - - 0.00000002452 60.0
TLS2_k127_2258979_17 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0000691 53.0
TLS2_k127_2258979_2 DNA ligase D DNA polymerase LigD K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 397.0
TLS2_k127_2258979_3 sarcosine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 358.0
TLS2_k127_2258979_4 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 335.0
TLS2_k127_2258979_5 SPTR Q471D1 TPR repeat Bacterial transcriptional activator domain Tetratricopeptide TPR_4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001748 283.0
TLS2_k127_2258979_6 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.000000000000000000000000000000000000000000000000000000002486 215.0
TLS2_k127_2258979_7 SMP-30/Gluconolaconase/LRE-like region K14274 - - 0.0000000000000000000000000000000000000000000000000000001655 205.0
TLS2_k127_2258979_8 Oxidoreductase molybdopterin binding domain K07147 - - 0.00000000000000000000000000000000000000000000001488 186.0
TLS2_k127_2258979_9 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000007919 171.0
TLS2_k127_227493_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009524 599.0
TLS2_k127_227493_1 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 565.0
TLS2_k127_227493_10 MDMPI C-terminal domain - - - 0.0000000000000000000000000004355 122.0
TLS2_k127_227493_11 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides K01468 - 3.5.2.7 0.00000000000000000000000001446 111.0
TLS2_k127_227493_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 454.0
TLS2_k127_227493_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006504 365.0
TLS2_k127_227493_4 Putative methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000018 271.0
TLS2_k127_227493_5 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE - - - 0.000000000000000000000000000000000000000000000000000000000001011 212.0
TLS2_k127_227493_6 PFAM LemA K03744 - - 0.00000000000000000000000000000000000000000000000000000000002404 213.0
TLS2_k127_227493_7 membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000232 225.0
TLS2_k127_227493_8 Methylmalonyl-CoA mutase K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000001179 188.0
TLS2_k127_227493_9 - - - - 0.00000000000000000000000000000000000000000000003988 180.0
TLS2_k127_22765_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009689 252.0
TLS2_k127_22765_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000001957 209.0
TLS2_k127_22765_2 - - - - 0.0000000000000000000000000000000000000000000000000000000003333 214.0
TLS2_k127_22765_3 arsR family - - - 0.0000000000000000000000000000000006646 133.0
TLS2_k127_22765_4 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.0001746 44.0
TLS2_k127_2353388_0 fumarylacetoacetate (FAA) hydrolase K05921 - 4.1.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 428.0
TLS2_k127_2353388_1 Bacterial low temperature requirement A protein (LtrA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 395.0
TLS2_k127_2353388_2 Peptidase C26 - - - 0.00000000000000000000000000000000000000000001591 172.0
TLS2_k127_2353388_3 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000000004063 119.0
TLS2_k127_2353388_4 RecB family exonuclease K07465 - - 0.000000003343 67.0
TLS2_k127_2407332_0 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 616.0
TLS2_k127_2407332_1 PFAM Aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 452.0
TLS2_k127_2407332_10 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02193,K02194 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 0.0000000000000000000000000000000000006858 149.0
TLS2_k127_2407332_11 alpha beta K06889 - - 0.000000000000000000000000000000002236 141.0
TLS2_k127_2407332_12 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.00000000000000000000002465 108.0
TLS2_k127_2407332_13 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000002802 98.0
TLS2_k127_2407332_14 Thiol-disulfide isomerase-like thioredoxin K02199 - - 0.00000000000000000001689 95.0
TLS2_k127_2407332_15 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.000000000000000000117 99.0
TLS2_k127_2407332_16 Protein of unknown function (DUF1232) - - - 0.0000000000000000006842 92.0
TLS2_k127_2407332_17 subunit of a heme lyase K02200 - - 0.00000000000000003784 93.0
TLS2_k127_2407332_18 peptidyl-tyrosine sulfation - - - 0.0000000000007948 79.0
TLS2_k127_2407332_19 - - - - 0.0000009381 53.0
TLS2_k127_2407332_2 Contains 3'-5'exonuclease domain K02342 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008309 422.0
TLS2_k127_2407332_20 Acyl transferase domain K00645,K13935,K15327 - 2.3.1.39 0.00000294 51.0
TLS2_k127_2407332_21 Prolipoprotein diacylglyceryl transferase - - - 0.0008427 51.0
TLS2_k127_2407332_3 Anion-transporting ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 363.0
TLS2_k127_2407332_4 Beta-eliminating lyase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008113 280.0
TLS2_k127_2407332_5 Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000001964 208.0
TLS2_k127_2407332_6 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000000000000000000000000000000000000000000000000404 197.0
TLS2_k127_2407332_7 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000000001217 187.0
TLS2_k127_2407332_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000554 180.0
TLS2_k127_2407332_9 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000214 173.0
TLS2_k127_2440777_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1070.0
TLS2_k127_2440777_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000001133 170.0
TLS2_k127_2440777_10 NfeD-like C-terminal, partner-binding - - - 0.00005426 53.0
TLS2_k127_2440777_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000002177 159.0
TLS2_k127_2440777_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000002132 156.0
TLS2_k127_2440777_4 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000003068 167.0
TLS2_k127_2440777_5 Domain of unknown function (DUF4397) - - - 0.000000000000000000000000000000000000009256 162.0
TLS2_k127_2440777_6 PFAM transcriptional regulator PadR family protein K10947 - - 0.0000000000000000000000000000001745 130.0
TLS2_k127_2440777_7 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000003635 139.0
TLS2_k127_2440777_8 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000326 96.0
TLS2_k127_2440777_9 Cell wall hydrolase autolysin K01448 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 0.000000000000006283 88.0
TLS2_k127_2584574_0 ATPase P-type (Transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 355.0
TLS2_k127_2584574_1 Sporulation and spore germination - - - 0.0000000000000000000000000000000000000000000000000000001226 206.0
TLS2_k127_2584574_2 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000005577 171.0
TLS2_k127_2584574_3 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000006855 155.0
TLS2_k127_2584574_4 Belongs to the PEP-utilizing enzyme family K01007 - 2.7.9.2 0.0000000000000000000000000000003918 130.0
TLS2_k127_2584574_5 COG0662 Mannose-6-phosphate isomerase - - - 0.0000000000000000000000009184 107.0
TLS2_k127_2584574_6 - K03641 - - 0.00000000000000000000004993 116.0
TLS2_k127_2584574_7 alpha/beta hydrolase fold - - - 0.00000001079 64.0
TLS2_k127_2622855_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004805 434.0
TLS2_k127_2622855_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 418.0
TLS2_k127_2622855_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 392.0
TLS2_k127_2622855_3 Belongs to the ABC transporter superfamily K02031,K02032,K10823,K13896,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 384.0
TLS2_k127_2622855_4 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 323.0
TLS2_k127_2677644_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 1.954e-231 738.0
TLS2_k127_2677644_1 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000543 482.0
TLS2_k127_2677644_10 Ferritin-like domain K04047 - - 0.000000000000000000000000000000000000000000000003289 179.0
TLS2_k127_2677644_11 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000000000001929 168.0
TLS2_k127_2677644_12 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000037 147.0
TLS2_k127_2677644_13 IMP dehydrogenase activity K02902 - - 0.00000000000000000000000000003122 123.0
TLS2_k127_2677644_14 LysE type translocator - - - 0.000000000000000000000000005351 113.0
TLS2_k127_2677644_15 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000000000000000000002285 108.0
TLS2_k127_2677644_16 LysE type translocator - - - 0.00000000000000000000005251 100.0
TLS2_k127_2677644_17 NhaP-type Na H and K H antiporters with a unique C-terminal domain K11105 - - 0.0000000000000002396 85.0
TLS2_k127_2677644_18 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.00000000000136 70.0
TLS2_k127_2677644_19 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000001015 62.0
TLS2_k127_2677644_2 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 465.0
TLS2_k127_2677644_3 Aminoglycoside/hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 396.0
TLS2_k127_2677644_4 Belongs to the GcvT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005029 359.0
TLS2_k127_2677644_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 349.0
TLS2_k127_2677644_6 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006646 315.0
TLS2_k127_2677644_7 Cupin superfamily protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 307.0
TLS2_k127_2677644_8 Sucrase/ferredoxin-like - - - 0.00000000000000000000000000000000000000000000000000002233 201.0
TLS2_k127_2677644_9 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000002358 185.0
TLS2_k127_270719_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564 2.7.4.1 1.229e-244 773.0
TLS2_k127_270719_1 glutamine synthetase K01915 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009865 432.0
TLS2_k127_270719_2 TIGRFAM phosphate binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003928 259.0
TLS2_k127_270719_3 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000001903 259.0
TLS2_k127_270719_4 probably responsible for the translocation of the substrate across the membrane K02037,K02038 - - 0.0000000000000000000000000000000000000000000000000000000000001719 217.0
TLS2_k127_270719_5 Low molecular weight phosphatase family - - - 0.00000000000000000000000000000000000000000000000000005553 194.0
TLS2_k127_270719_6 Belongs to the MIP aquaporin (TC 1.A.8) family - - - 0.00000000000000000000000000000000000000005398 160.0
TLS2_k127_270719_7 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000001344 89.0
TLS2_k127_270719_8 Bacterial regulatory proteins, tetR family - - - 0.0000000000005795 76.0
TLS2_k127_270720_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 5.187e-201 641.0
TLS2_k127_270720_1 Belongs to the glutamine synthetase family K01915 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009381 422.0
TLS2_k127_270720_10 RDD family - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000003453 114.0
TLS2_k127_270720_11 NUDIX hydrolase - - - 0.0000000000000001592 83.0
TLS2_k127_270720_12 Protein of unknown function (DUF559) - - - 0.00000001037 66.0
TLS2_k127_270720_13 Protein conserved in bacteria - - - 0.00000003819 63.0
TLS2_k127_270720_2 cystathione gamma lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 422.0
TLS2_k127_270720_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 331.0
TLS2_k127_270720_4 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000001052 193.0
TLS2_k127_270720_5 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000002107 196.0
TLS2_k127_270720_6 heme binding K21471,K21472 - - 0.000000000000000000000000000000000000000002109 172.0
TLS2_k127_270720_7 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000001511 161.0
TLS2_k127_270720_8 Iron-sulphur cluster biosynthesis K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564 - 0.0000000000000000000000000000000000001048 144.0
TLS2_k127_270720_9 Has endoribonuclease activity on mRNA K09022 - 3.5.99.10 0.00000000000000000000000000000007278 130.0
TLS2_k127_2724640_0 SMART alpha amylase, catalytic sub domain K01187,K05343 - 3.2.1.1,3.2.1.20,5.4.99.16 0.0 1257.0
TLS2_k127_2724640_1 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 9.661e-238 753.0
TLS2_k127_2724640_2 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 543.0
TLS2_k127_2724640_3 Belongs to the glycosyl hydrolase 57 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 361.0
TLS2_k127_2761234_0 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 542.0
TLS2_k127_2761234_1 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 485.0
TLS2_k127_2761234_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 304.0
TLS2_k127_2761234_3 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006243 269.0
TLS2_k127_2761234_4 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009706 256.0
TLS2_k127_2761234_5 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.000000000000000000000000000000000000000000000000000000005275 220.0
TLS2_k127_2761234_6 Periplasmic binding protein domain K10439 - - 0.00000000000000000000000000000000000008181 156.0
TLS2_k127_2763329_0 PFAM NAD-dependent epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 446.0
TLS2_k127_2763329_10 - - - - 0.000000000001364 77.0
TLS2_k127_2763329_11 protein folding K09510,K09519 - - 0.0000000002777 69.0
TLS2_k127_2763329_12 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000002905 53.0
TLS2_k127_2763329_2 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 296.0
TLS2_k127_2763329_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003641 284.0
TLS2_k127_2763329_4 RNA polymerase, sigma-24 subunit, ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000001246 243.0
TLS2_k127_2763329_5 - - - - 0.000000000000000000000000000000000000000000000000003379 196.0
TLS2_k127_2763329_7 RNA polymerase, sigma-24 subunit, ECF subfamily K03088 - - 0.00000000000000000000000000000000000000003264 158.0
TLS2_k127_2763329_8 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000826 168.0
TLS2_k127_2763329_9 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.00000000000000001978 90.0
TLS2_k127_2844619_0 xanthine dehydrogenase activity K03520 - 1.2.5.3 0.0 1438.0
TLS2_k127_2844619_1 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 2.582e-272 865.0
TLS2_k127_2844619_10 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009309 332.0
TLS2_k127_2844619_11 XdhC Rossmann domain K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003833 336.0
TLS2_k127_2844619_12 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 297.0
TLS2_k127_2844619_13 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000124 268.0
TLS2_k127_2844619_14 Protein containing von Willebrand factor type A (vWA) domain K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002001 261.0
TLS2_k127_2844619_15 Belongs to the RNA methyltransferase TrmD family K00554,K01770 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000002287 233.0
TLS2_k127_2844619_16 peroxiredoxin activity K03386,K03564,K16922 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000001101 229.0
TLS2_k127_2844619_17 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 GO:0003674,GO:0003824,GO:0004845,GO:0004849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016763,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000004248 208.0
TLS2_k127_2844619_18 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.000000000000000000000000000000000000000000000000000000001089 209.0
TLS2_k127_2844619_19 - - - - 0.00000000000000000000000000000000000000000000000000000005465 203.0
TLS2_k127_2844619_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 496.0
TLS2_k127_2844619_20 TRANSCRIPTIONal - - - 0.000000000000000000000000000000000000000000000000001591 200.0
TLS2_k127_2844619_21 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000000000000000000000000002453 199.0
TLS2_k127_2844619_22 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.000000000000000000000000000000000000000000000000004921 192.0
TLS2_k127_2844619_23 Ribosomal protein L19 K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.000000000000000000000000000000000000000000003937 166.0
TLS2_k127_2844619_24 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000002734 158.0
TLS2_k127_2844619_25 Protein of unknown function (DUF2469) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000002319 148.0
TLS2_k127_2844619_26 - - - - 0.000000000000000000000000000000000000002539 154.0
TLS2_k127_2844619_27 - - - - 0.0000000000000000000000000001894 115.0
TLS2_k127_2844619_28 XdhC and CoxI family - - - 0.000000000000000000000000002083 127.0
TLS2_k127_2844619_29 - - - - 0.000000000000000000000000002159 113.0
TLS2_k127_2844619_3 Exporter of polyketide antibiotics K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005935 501.0
TLS2_k127_2844619_30 - - - - 0.000000000000000000000000008727 114.0
TLS2_k127_2844619_31 XdhC Rossmann domain K07402 - - 0.00000000000000000000001067 111.0
TLS2_k127_2844619_32 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000002486 105.0
TLS2_k127_2844619_33 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.00000000000000000001201 98.0
TLS2_k127_2844619_35 - - - - 0.000000000000002531 84.0
TLS2_k127_2844619_36 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000002702 79.0
TLS2_k127_2844619_38 - - - - 0.00000000000002643 75.0
TLS2_k127_2844619_4 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 482.0
TLS2_k127_2844619_40 6-O-methylguanine DNA methyltransferase, DNA binding domain - - - 0.00000000002462 67.0
TLS2_k127_2844619_44 KH domain K06960 - - 0.00000002359 59.0
TLS2_k127_2844619_45 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000001737 56.0
TLS2_k127_2844619_46 Belongs to the UPF0102 family K07460 - - 0.0001122 52.0
TLS2_k127_2844619_5 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 449.0
TLS2_k127_2844619_6 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007925 428.0
TLS2_k127_2844619_7 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 415.0
TLS2_k127_2844619_8 xanthine dehydrogenase activity K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003844 371.0
TLS2_k127_2844619_9 COG0714 MoxR-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 355.0
TLS2_k127_2860667_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 2.702e-223 714.0
TLS2_k127_2860667_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 514.0
TLS2_k127_2860667_10 PFAM Cell envelope-related transcriptional attenuator - - - 0.0000000000000000000001247 110.0
TLS2_k127_2860667_11 Thioesterase superfamily K02614 - - 0.0000000000000000000002039 103.0
TLS2_k127_2860667_12 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000005557 78.0
TLS2_k127_2860667_13 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000009745 74.0
TLS2_k127_2860667_14 carbon-nitrogen ligase activity, with glutamine as amido-N-donor K09117 - - 0.000005871 52.0
TLS2_k127_2860667_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 422.0
TLS2_k127_2860667_3 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00850,K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 423.0
TLS2_k127_2860667_4 belongs to the sigma-70 factor family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 391.0
TLS2_k127_2860667_5 Winged helix DNA-binding domain K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000047 342.0
TLS2_k127_2860667_6 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 329.0
TLS2_k127_2860667_7 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000791 216.0
TLS2_k127_2860667_8 Phosphoribosylformylglycinamidine cyclo-ligase K01933 GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016882,GO:0044424,GO:0044444,GO:0044464 6.3.3.1 0.00000000000000000000000000000000000000000000000000000009674 200.0
TLS2_k127_2860667_9 isoleucine patch - - - 0.000000000000000000000000000000000000000000006934 168.0
TLS2_k127_2861736_0 COGs COG1253 Hemolysins and related protein containing CBS domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 574.0
TLS2_k127_2861736_1 COGs COG1253 Hemolysins and related protein containing CBS domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 517.0
TLS2_k127_2861736_2 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000002409 216.0
TLS2_k127_2861736_3 - K03641 - - 0.00000000000000000000005135 113.0
TLS2_k127_2861736_4 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000004033 86.0
TLS2_k127_2861736_6 - - - - 0.00002472 53.0
TLS2_k127_2861736_7 Enoyl-(Acyl carrier protein) reductase - - - 0.00004876 49.0
TLS2_k127_2868963_0 Aminomethyltransferase folate-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008352 566.0
TLS2_k127_2868963_1 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008044 503.0
TLS2_k127_2868963_10 cytochrome c oxidase K02351,K02862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000108 254.0
TLS2_k127_2868963_11 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.00000000000000000000000000000000000000000000000000000000000000192 227.0
TLS2_k127_2868963_12 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000466 200.0
TLS2_k127_2868963_13 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000004739 198.0
TLS2_k127_2868963_14 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) - - - 0.00000000000000000000000000000000000000000000000000003139 199.0
TLS2_k127_2868963_15 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000000000000000000000000000005061 190.0
TLS2_k127_2868963_16 Histidine kinase - - - 0.000000000000000000000000000000000000000000000003405 198.0
TLS2_k127_2868963_17 SCO1 SenC K07152 - - 0.00000000000000000000000000000000000000000000003099 180.0
TLS2_k127_2868963_18 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000003558 105.0
TLS2_k127_2868963_19 helix_turn _helix lactose operon repressor - - - 0.00000000000000002928 86.0
TLS2_k127_2868963_2 Daunorubicin resistance ABC transporter ATP-binding subunit K01990,K18232 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 439.0
TLS2_k127_2868963_20 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000003823 86.0
TLS2_k127_2868963_21 Copper chaperone PCu(A)C K09796 - - 0.00000000000003842 84.0
TLS2_k127_2868963_22 Domain of unknown function (DUF4349) - - - 0.00000000000008351 84.0
TLS2_k127_2868963_23 Histidine kinase - - - 0.0000000000001264 84.0
TLS2_k127_2868963_24 Cro/C1-type HTH DNA-binding domain K07729 - - 0.0000000000002022 75.0
TLS2_k127_2868963_25 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000001179 71.0
TLS2_k127_2868963_26 Transmembrane domain of unknown function (DUF3566) - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000007242 66.0
TLS2_k127_2868963_27 cellular response to nickel ion - - - 0.0000001368 61.0
TLS2_k127_2868963_3 COG0025 NhaP-type Na H and K H antiporters - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 431.0
TLS2_k127_2868963_4 transport, permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 382.0
TLS2_k127_2868963_5 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007323 384.0
TLS2_k127_2868963_6 WYL domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 349.0
TLS2_k127_2868963_7 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005092 336.0
TLS2_k127_2868963_8 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 340.0
TLS2_k127_2868963_9 Short-chain Dehydrogenase reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001643 267.0
TLS2_k127_2870513_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007869 593.0
TLS2_k127_2870513_1 amino acid ABC transporter, ATP-binding protein K02028,K17076 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 366.0
TLS2_k127_2870513_2 ABC transporter K02029,K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 294.0
TLS2_k127_2870513_3 amino acid transport K09969 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000288 283.0
TLS2_k127_2870513_4 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07776 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002119 263.0
TLS2_k127_2870513_5 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000002745 248.0
TLS2_k127_2870513_6 Bacterial periplasmic substrate-binding proteins K02030 - - 0.0000000000000000000000000000000000000000000000000000002673 210.0
TLS2_k127_2870513_7 acetyltransferase - - - 0.0000000000000000000000000003172 126.0
TLS2_k127_2870513_8 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000003315 59.0
TLS2_k127_2883796_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 2.459e-219 702.0
TLS2_k127_2883796_1 PGAP1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000004 226.0
TLS2_k127_2883796_2 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0000000000000000000000000000000417 135.0
TLS2_k127_2883796_3 Belongs to the CinA family - - - 0.0000000000000000000000002103 112.0
TLS2_k127_2885670_0 Belongs to the group II decarboxylase family K01580 - 4.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000768 612.0
TLS2_k127_2885670_1 Sulfate permease family K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 558.0
TLS2_k127_2885670_2 Flavin-binding monooxygenase-like K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 421.0
TLS2_k127_2885670_3 Prokaryotic glutathione synthetase, ATP-grasp domain K01920 - 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 403.0
TLS2_k127_2885670_4 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006898 350.0
TLS2_k127_2885670_5 Truncated hemoglobins K06886 - - 0.00000000000000000000000000000000000000000000000000000000001606 210.0
TLS2_k127_2885670_6 chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000006022 217.0
TLS2_k127_2885670_7 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000004735 197.0
TLS2_k127_2885670_8 membrane - - - 0.00000000000000000000000000000000000000000000000000222 186.0
TLS2_k127_2885670_9 - - - - 0.000000000000000000000000000000000000000000000003783 184.0
TLS2_k127_2899429_0 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008567 487.0
TLS2_k127_2899429_1 Cytochrome P450 K00493 - 1.14.14.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 335.0
TLS2_k127_2900547_0 SecA preprotein cross-linking domain K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 3.652e-309 970.0
TLS2_k127_2900547_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 517.0
TLS2_k127_2900547_10 pathogenesis - - - 0.000000001363 69.0
TLS2_k127_2900547_11 Competence protein - GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 - 0.000000004337 66.0
TLS2_k127_2900547_12 Protein of unknown function (DUF3499) - - - 0.0000002526 55.0
TLS2_k127_2900547_2 the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells K01840 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 453.0
TLS2_k127_2900547_3 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 389.0
TLS2_k127_2900547_4 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006491 370.0
TLS2_k127_2900547_5 Sugar isomerase (SIS) K15916 - 5.3.1.8,5.3.1.9 0.0000000000000000000000000000000000000000000000000001083 198.0
TLS2_k127_2900547_6 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000426 177.0
TLS2_k127_2900547_7 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000001375 171.0
TLS2_k127_2900547_8 - - - - 0.000000000008513 73.0
TLS2_k127_2900547_9 Trm112p-like protein K09791 - - 0.00000000005157 68.0
TLS2_k127_2904689_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 9.599e-246 773.0
TLS2_k127_2904689_1 Arginosuccinate synthase K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 557.0
TLS2_k127_2904689_2 Ferredoxin oxidoreductase K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006742 441.0
TLS2_k127_2904689_3 Argininosuccinate lyase C-terminal K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007809 383.0
TLS2_k127_2904689_4 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 323.0
TLS2_k127_2904689_5 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000002268 248.0
TLS2_k127_2904689_6 Protein of unknown function (DUF3048) C-terminal domain - - - 0.000000000000000000000000000000000002716 151.0
TLS2_k127_2904689_7 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000001689 145.0
TLS2_k127_2904689_8 Oxidoreductase FAD-binding domain K02613 - - 0.00000000000000000000000000005874 117.0
TLS2_k127_2904689_9 Sigma-70 region 2 - - - 0.00002319 56.0
TLS2_k127_2918156_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 5.042e-205 655.0
TLS2_k127_2918156_1 DegT/DnrJ/EryC1/StrS aminotransferase family K13010,K19430 - 2.6.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 440.0
TLS2_k127_2918156_10 Glycosyltransferase Family 4 K19424 - - 0.0000000000000000000000000000000000000000000000000001648 205.0
TLS2_k127_2918156_11 Bacterial sugar transferase - - - 0.0000000000000000000000000000000000000000000000000002064 193.0
TLS2_k127_2918156_12 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000004302 185.0
TLS2_k127_2918156_13 NAD-dependent epimerase dehydratase K01784,K17947 - 5.1.3.2,5.1.3.25 0.0000000000000000000000000000000000000000000001584 179.0
TLS2_k127_2918156_14 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000009978 153.0
TLS2_k127_2918156_15 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000003278 155.0
TLS2_k127_2918156_16 PFAM Polysaccharide deacetylase - - - 0.0000000000000000000000000000000001243 142.0
TLS2_k127_2918156_17 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000001271 137.0
TLS2_k127_2918156_18 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000006682 102.0
TLS2_k127_2918156_19 biosynthesis protein - - - 0.00005669 57.0
TLS2_k127_2918156_2 Domain of unknown function (DUF2172) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 382.0
TLS2_k127_2918156_3 Nucleotidyl transferase K00978 - 2.7.7.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004232 344.0
TLS2_k127_2918156_4 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000557 358.0
TLS2_k127_2918156_5 galactosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 338.0
TLS2_k127_2918156_6 galactosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005856 254.0
TLS2_k127_2918156_7 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000218 221.0
TLS2_k127_2918156_8 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008830,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.1.3.13 0.00000000000000000000000000000000000000000000000000002962 194.0
TLS2_k127_2918156_9 - - - - 0.0000000000000000000000000000000000000000000000000001269 204.0
TLS2_k127_292710_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.2.1.1 1.384e-202 646.0
TLS2_k127_292710_1 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000721 388.0
TLS2_k127_292710_2 Domain of unknown function (DUF427) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 316.0
TLS2_k127_292710_3 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000002259 197.0
TLS2_k127_292710_4 NUDIX domain - - - 0.000000000000000000000000000000000000009791 151.0
TLS2_k127_292710_5 CHAD - - - 0.0000000000000000000000000000000007375 147.0
TLS2_k127_292710_6 PFAM GCN5-related N-acetyltransferase - - - 0.00000000002194 72.0
TLS2_k127_2935933_0 Probable RNA and SrmB- binding site of polymerase A K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003761 492.0
TLS2_k127_2935933_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 334.0
TLS2_k127_2935933_2 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 318.0
TLS2_k127_2935933_3 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005378 285.0
TLS2_k127_2935933_4 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000089 273.0
TLS2_k127_2935933_5 belongs to the sigma-70 factor family, ECF subfamily K03088 GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000001434 158.0
TLS2_k127_2935933_6 PFAM Endonuclease Exonuclease phosphatase - - - 0.000000000000000000000000000000000000002591 158.0
TLS2_k127_2935933_7 serine threonine protein kinase - - - 0.0000000000008977 80.0
TLS2_k127_2935933_8 PFAM GCN5-related N-acetyltransferase - - - 0.000000000003537 79.0
TLS2_k127_2957200_0 Alpha amylase catalytic K01187,K05343 - 3.2.1.1,3.2.1.20,5.4.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 592.0
TLS2_k127_2957200_1 FAD binding domain K20218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 584.0
TLS2_k127_2957200_10 ABC-type sugar transport system, permease component K10234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006965 361.0
TLS2_k127_2957200_11 GlcNAc-PI de-N-acetylase K16515 - 4.2.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 341.0
TLS2_k127_2957200_12 COG1175 ABC-type sugar transport systems permease components K10233 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004576 336.0
TLS2_k127_2957200_13 Bacterial extracellular solute-binding protein K10232 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 326.0
TLS2_k127_2957200_14 Threonine synthase N terminus K01733 GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 323.0
TLS2_k127_2957200_15 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001411 289.0
TLS2_k127_2957200_16 Aldolase/RraA K10218 - 4.1.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008385 275.0
TLS2_k127_2957200_17 Alcohol dehydrogenase GroES-like domain K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000002852 267.0
TLS2_k127_2957200_18 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005021 259.0
TLS2_k127_2957200_19 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002353 251.0
TLS2_k127_2957200_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 555.0
TLS2_k127_2957200_20 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002873 248.0
TLS2_k127_2957200_21 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000009085 233.0
TLS2_k127_2957200_22 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000322 224.0
TLS2_k127_2957200_23 - - - - 0.0000000000000000000000000000000000000000000003438 173.0
TLS2_k127_2957200_24 Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - - 0.000000000000000000000000000000000000000000671 163.0
TLS2_k127_2957200_25 Yqey-like protein K09117 - - 0.000000000000000000000000002574 126.0
TLS2_k127_2957200_26 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000008426 104.0
TLS2_k127_2957200_27 - - - - 0.0000000000000000001819 89.0
TLS2_k127_2957200_29 Transcription factor WhiB K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0002274 44.0
TLS2_k127_2957200_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007999 517.0
TLS2_k127_2957200_4 ATPases associated with a variety of cellular activities K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007075 457.0
TLS2_k127_2957200_5 Glycosyl hydrolase family 1 K05350 - 3.2.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 451.0
TLS2_k127_2957200_6 PrpF protein K16514 - 5.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005213 421.0
TLS2_k127_2957200_7 Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols K04101 - 1.13.11.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004054 409.0
TLS2_k127_2957200_8 Domain of unknown function (DUF4032) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 392.0
TLS2_k127_2957200_9 Amidohydrolase K10221 - 3.1.1.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 363.0
TLS2_k127_2995758_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1242.0
TLS2_k127_2995758_1 ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis K13527 GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 - 7.141e-218 690.0
TLS2_k127_2995758_10 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 415.0
TLS2_k127_2995758_11 Belongs to the phosphoglycerate kinase family K00927,K01803 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 2.7.2.3,5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 368.0
TLS2_k127_2995758_12 PFAM thiamine pyrophosphate protein domain protein TPP-binding K09459 - 4.1.1.82 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 328.0
TLS2_k127_2995758_13 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008449 323.0
TLS2_k127_2995758_14 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003865 295.0
TLS2_k127_2995758_15 Displays ATPase and GTPase activities K06958 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002555 295.0
TLS2_k127_2995758_16 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000005057 246.0
TLS2_k127_2995758_17 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001592 234.0
TLS2_k127_2995758_18 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000009302 210.0
TLS2_k127_2995758_19 Required for morphogenesis under gluconeogenic growth conditions - - - 0.00000000000000000000000000000000000000000000000000000003942 208.0
TLS2_k127_2995758_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 5.075e-207 660.0
TLS2_k127_2995758_20 Belongs to the P(II) protein family K04751 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000004414 156.0
TLS2_k127_2995758_21 hydroxyacid-oxoacid transhydrogenase activity K19954 - - 0.00000000000000000000000000000000000000004152 166.0
TLS2_k127_2995758_22 PhoQ Sensor - - - 0.00000000000000000000000000000000000005753 163.0
TLS2_k127_2995758_23 Transmembrane secretion effector - - - 0.0000000000000000000000000000000002353 149.0
TLS2_k127_2995758_24 Pup-ligase protein K20814 - 3.5.1.119 0.0000000000000000000000000000000003063 135.0
TLS2_k127_2995758_25 pyridoxamine 5-phosphate - - - 0.0000000000000000000000000000002393 129.0
TLS2_k127_2995758_26 - - - - 0.0000000000000000000000000000007321 128.0
TLS2_k127_2995758_27 Pfam Adenylate and Guanylate cyclase catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.0000000000000000000000000000008391 126.0
TLS2_k127_2995758_28 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000001782 113.0
TLS2_k127_2995758_29 Preprotein translocase SecG subunit K03075 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000002707 79.0
TLS2_k127_2995758_3 Phosphoenolpyruvate phosphomutase K01841 - 5.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 525.0
TLS2_k127_2995758_30 methyltransferase - - - 0.0000000000000342 82.0
TLS2_k127_2995758_31 PFAM Acyltransferase family - - - 0.000000007478 58.0
TLS2_k127_2995758_4 trisaccharide binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 533.0
TLS2_k127_2995758_5 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 496.0
TLS2_k127_2995758_6 Aminotransferase class-III K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005639 482.0
TLS2_k127_2995758_7 TrkA-N domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 447.0
TLS2_k127_2995758_8 ADP-glyceromanno-heptose 6-epimerase activity K01710,K08678 - 4.1.1.35,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 435.0
TLS2_k127_2995758_9 Ammonium Transporter Family K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 436.0
TLS2_k127_3027212_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 6.682e-246 777.0
TLS2_k127_3027212_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 312.0
TLS2_k127_3027212_2 Histidine kinase - - - 0.000000000000000000000000000167 129.0
TLS2_k127_3027212_3 - - - - 0.000000000000000000002109 96.0
TLS2_k127_3027212_4 Phosphoglycerate mutase family K02226,K22316 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 0.0000000000000000005428 99.0
TLS2_k127_3027212_5 Belongs to the phosphoglycerate mutase family K01834,K22306 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237 3.1.3.85,5.4.2.11 0.00000000000000007837 93.0
TLS2_k127_3027212_6 HNH endonuclease - - - 0.00000000000000009381 90.0
TLS2_k127_3027212_7 GNAT family - - - 0.00000006332 63.0
TLS2_k127_3073285_0 PFAM ABC transporter transmembrane region K06147 - - 1.213e-208 668.0
TLS2_k127_3073285_1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000001178 219.0
TLS2_k127_3073285_2 Lipoate-protein ligase - - - 0.0000000000000000000000000000000000000000000003362 181.0
TLS2_k127_3073285_3 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000004448 145.0
TLS2_k127_3073285_4 alpha/beta hydrolase fold - - - 0.000000000000000000000000000004029 133.0
TLS2_k127_3095325_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 299.0
TLS2_k127_3095325_1 sequence-specific DNA binding K00567,K13529,K15051 - 2.1.1.63,3.2.2.21 0.00000000000000000000000000000000000000000000000000005239 195.0
TLS2_k127_3095325_2 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000003894 130.0
TLS2_k127_3095325_3 Belongs to the transketolase family K00615 - 2.2.1.1 0.000000000000000000000000002894 112.0
TLS2_k127_313888_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 551.0
TLS2_k127_313888_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 505.0
TLS2_k127_313888_2 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008816 389.0
TLS2_k127_313888_3 VanW like protein - - - 0.00000000000000000000000000000000000000000000000000000001597 218.0
TLS2_k127_313888_4 succinyl-diaminopimelate desuccinylase K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000002512 189.0
TLS2_k127_313888_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 0.000000000000000000117 93.0
TLS2_k127_3156367_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 586.0
TLS2_k127_3156367_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000885 364.0
TLS2_k127_3156367_10 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000001293 160.0
TLS2_k127_3156367_11 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000001713 115.0
TLS2_k127_3156367_12 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000006759 104.0
TLS2_k127_3156367_13 - - - - 0.0000001494 57.0
TLS2_k127_3156367_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007669 349.0
TLS2_k127_3156367_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004856 289.0
TLS2_k127_3156367_4 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K14215,K21273 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008819 284.0
TLS2_k127_3156367_5 SMART Metal-dependent phosphohydrolase, HD region K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000001047 265.0
TLS2_k127_3156367_6 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000006448 206.0
TLS2_k127_3156367_7 Permease component K02069 - - 0.00000000000000000000000000000000000000000000000000001466 200.0
TLS2_k127_3156367_8 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000004768 177.0
TLS2_k127_3156367_9 PhoH family K06217 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000003597 165.0
TLS2_k127_3170144_0 Iron-containing alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005721 368.0
TLS2_k127_3170144_1 Periplasmic binding protein domain K02058,K10439,K17213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001077 248.0
TLS2_k127_3170144_2 Contains amidotransferase and phosphosugar isomerase domains K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000001631 234.0
TLS2_k127_3170144_3 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.0000000000000000000000000000000000000000000000000008576 201.0
TLS2_k127_3170144_4 Psort location Cytoplasmic, score - - - 0.0000000000000001874 89.0
TLS2_k127_3171477_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 4.585e-257 803.0
TLS2_k127_3171477_1 luciferase-like monooxygenase - - - 9.349e-222 694.0
TLS2_k127_3171477_10 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000295 283.0
TLS2_k127_3171477_11 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002118 280.0
TLS2_k127_3171477_12 FMN reductase K00299 - 1.5.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005633 276.0
TLS2_k127_3171477_13 Amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009554 279.0
TLS2_k127_3171477_14 NADPH:quinone reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003345 276.0
TLS2_k127_3171477_15 PFAM amidohydrolase 2 K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000004157 277.0
TLS2_k127_3171477_16 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002556 263.0
TLS2_k127_3171477_17 NMT1/THI5 like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001203 269.0
TLS2_k127_3171477_18 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002093 255.0
TLS2_k127_3171477_19 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000002528 250.0
TLS2_k127_3171477_2 Histidinol dehydrogenase K00013,K15509 - 1.1.1.23,1.1.1.308 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 436.0
TLS2_k127_3171477_20 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K00090 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000008636 260.0
TLS2_k127_3171477_21 PFAM amidohydrolase 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001152 242.0
TLS2_k127_3171477_22 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.000000000000000000000000000000000000000000000000000000000000000009853 236.0
TLS2_k127_3171477_23 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000008336 208.0
TLS2_k127_3171477_24 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000000000000004238 182.0
TLS2_k127_3171477_25 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01856,K01860,K19802 - 5.1.1.20,5.5.1.1,5.5.1.7 0.00000000000000000000000000000000000000000000173 179.0
TLS2_k127_3171477_26 ATPases associated with a variety of cellular activities K02049 - - 0.00000000000000000000000000000000000000000246 164.0
TLS2_k127_3171477_27 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000002268 168.0
TLS2_k127_3171477_28 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000146 152.0
TLS2_k127_3171477_29 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000002376 152.0
TLS2_k127_3171477_3 inositol 2-dehydrogenase activity K18106 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 436.0
TLS2_k127_3171477_30 phosphogluconate dehydrogenase (decarboxylating) activity K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000166 150.0
TLS2_k127_3171477_31 PFAM Bacterial regulatory proteins, gntR family - - - 0.000000000000000000000000000000000005676 145.0
TLS2_k127_3171477_32 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000001002 123.0
TLS2_k127_3171477_33 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.0000000000000000826 87.0
TLS2_k127_3171477_34 Major facilitator superfamily - - - 0.0003061 48.0
TLS2_k127_3171477_4 oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 405.0
TLS2_k127_3171477_5 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009745 383.0
TLS2_k127_3171477_6 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006626 385.0
TLS2_k127_3171477_7 FtsX-like permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 398.0
TLS2_k127_3171477_8 arylformamidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003782 325.0
TLS2_k127_3171477_9 nitric oxide dioxygenase activity K00528,K05784 GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009447 331.0
TLS2_k127_319305_0 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 420.0
TLS2_k127_319305_1 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008037 413.0
TLS2_k127_319305_10 antisigma factor binding - - - 0.00000000000002779 77.0
TLS2_k127_319305_12 sigma factor antagonist activity - - - 0.0000000000002736 74.0
TLS2_k127_319305_13 - - - - 0.000000000001254 76.0
TLS2_k127_319305_14 CAAX protease self-immunity K07052 - - 0.00000000001841 73.0
TLS2_k127_319305_15 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000001012 71.0
TLS2_k127_319305_16 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000001893 53.0
TLS2_k127_319305_17 PFAM Uracil-DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000197 50.0
TLS2_k127_319305_18 - - - - 0.00002982 53.0
TLS2_k127_319305_19 - - - - 0.00006785 48.0
TLS2_k127_319305_2 MASE1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002177 286.0
TLS2_k127_319305_3 RNA polymerase K03090 GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141 - 0.00000000000000000000000000000000000000000000007309 185.0
TLS2_k127_319305_4 PRC-barrel domain - - - 0.00000000000000000000000000000000000004913 149.0
TLS2_k127_319305_5 Rho termination factor, N-terminal domain - - - 0.0000000000000000000000000000001029 126.0
TLS2_k127_319305_6 translation release factor activity - - - 0.0000000000000000000007652 108.0
TLS2_k127_319305_7 Sigma 54 modulation/S30EA ribosomal protein C terminus - - - 0.000000000000000000003649 103.0
TLS2_k127_319305_8 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000003623 87.0
TLS2_k127_319305_9 Belongs to the UPF0337 (CsbD) family - - - 0.000000000000004616 76.0
TLS2_k127_3195779_0 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 284.0
TLS2_k127_3195779_1 N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000238 288.0
TLS2_k127_3195779_2 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009723 278.0
TLS2_k127_3195779_3 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.0000000000000000000000000000000000000000000000000000000000000000213 243.0
TLS2_k127_3195779_4 ABC 3 transport family K02075,K09819 - - 0.000000000000000000000000000000000000000000000000000000005097 203.0
TLS2_k127_3195779_5 Ferric uptake regulator family K03711 - - 0.0000000000000000000000007282 109.0
TLS2_k127_3195779_6 branched-chain amino acid - GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015238,GO:0015318,GO:0015562,GO:0015658,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903785,GO:1903825,GO:1905039 - 0.000000000000001863 85.0
TLS2_k127_3195779_7 Conserved TM helix repeat-containing protein - - - 0.0001064 52.0
TLS2_k127_3231874_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008709 603.0
TLS2_k127_3231874_1 Belongs to the folylpolyglutamate synthase family K11754 GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 316.0
TLS2_k127_3231874_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.0000000000000000000000000000000000000000000000000006274 186.0
TLS2_k127_3231874_3 domain protein K02476,K12373 - 2.7.13.3,3.2.1.52 0.00000000003494 77.0
TLS2_k127_3231874_4 Cell division protein FtsA K03569 - - 0.00000000008532 63.0
TLS2_k127_3231874_5 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0003641 43.0
TLS2_k127_3282473_0 NADH flavin oxidoreductase NADH oxidase K00354,K09461 GO:0000003,GO:0000302,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006950,GO:0006979,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009620,GO:0009694,GO:0009695,GO:0009791,GO:0009908,GO:0009987,GO:0010035,GO:0010193,GO:0010817,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016629,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0042221,GO:0042445,GO:0042446,GO:0042493,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046677,GO:0048367,GO:0048437,GO:0048438,GO:0048443,GO:0048466,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0051704,GO:0051707,GO:0055114,GO:0061458,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0090567,GO:0099402,GO:1901576,GO:1901700 1.14.13.40,1.6.99.1 3.436e-291 912.0
TLS2_k127_3282473_1 TOBE domain K02017,K02018 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 381.0
TLS2_k127_3282473_2 Binding-protein-dependent transport system inner membrane component K02017,K02018 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 358.0
TLS2_k127_3282473_3 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704 - 0.000000000000000000000000000000000000000000000000000000001489 209.0
TLS2_k127_3282473_4 Major facilitator Superfamily K07552,K19577 - - 0.000000000000000000000000000000000000000000000000000000009277 216.0
TLS2_k127_3282473_5 ROK family - - - 0.00000000000000000000000000000000000000000000000000001158 203.0
TLS2_k127_3282473_6 Transcriptional regulator PadR-like family K10917 - - 0.00000000000000000000000145 118.0
TLS2_k127_3300281_0 ATPases associated with a variety of cellular activities K02006,K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 314.0
TLS2_k127_3300281_1 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000122 271.0
TLS2_k127_3300281_2 Cobalt ABC transporter K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001437 247.0
TLS2_k127_3300281_3 Cbs domain - - - 0.0000000000000000000000006948 110.0
TLS2_k127_3300281_4 Belongs to the Fur family K03711,K09825 - - 0.0000000000000000001002 94.0
TLS2_k127_3300281_5 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000002317 79.0
TLS2_k127_3300281_6 phosphorelay signal transduction system - - - 0.000000000003659 72.0
TLS2_k127_3351568_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000345 327.0
TLS2_k127_3351568_1 Glycosyltransferase family 28 C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 311.0
TLS2_k127_3351568_10 N-terminal domain of galactosyltransferase - - - 0.000000000000000000000000000007699 138.0
TLS2_k127_3351568_11 SpoIID LytB domain protein - - - 0.00000000000000000000000000004243 128.0
TLS2_k127_3351568_12 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000000000001225 121.0
TLS2_k127_3351568_13 S-layer domain protein - - - 0.00000000000007095 85.0
TLS2_k127_3351568_14 - - - - 0.00000000002031 73.0
TLS2_k127_3351568_15 D-alanyl-D-alanine carboxypeptidase - - - 0.0000007912 63.0
TLS2_k127_3351568_2 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006884 283.0
TLS2_k127_3351568_3 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000181 274.0
TLS2_k127_3351568_4 Glycosyl transferase, family 2 K16555,K16564 - - 0.00000000000000000000000000000000000000000000000000000004687 222.0
TLS2_k127_3351568_5 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000054 205.0
TLS2_k127_3351568_6 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000009285 182.0
TLS2_k127_3351568_7 - - - - 0.000000000000000000000000000000000000005824 165.0
TLS2_k127_3351568_8 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000009744 158.0
TLS2_k127_3351568_9 Polysaccharide pyruvyl transferase - - - 0.0000000000000000000000000000004776 142.0
TLS2_k127_3499821_0 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000084 213.0
TLS2_k127_3499821_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000001252 179.0
TLS2_k127_3499821_2 glyoxalase III activity - - - 0.0000000000000000000000000000000000001392 146.0
TLS2_k127_3499821_3 - - - - 0.00000000008134 69.0
TLS2_k127_3511083_0 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 572.0
TLS2_k127_3511083_1 Beta propeller domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 428.0
TLS2_k127_3511083_2 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 388.0
TLS2_k127_3511083_3 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009263 367.0
TLS2_k127_3511083_4 sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000009111 160.0
TLS2_k127_3511083_5 - - - - 0.00000000000000000000000000000001244 132.0
TLS2_k127_3511083_6 TadE-like protein - - - 0.0000001278 59.0
TLS2_k127_3511083_8 TadE-like protein - - - 0.0002837 50.0
TLS2_k127_3511083_9 Putative Flp pilus-assembly TadE/G-like - - - 0.0008914 51.0
TLS2_k127_3546815_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 1.344e-306 965.0
TLS2_k127_3546815_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 590.0
TLS2_k127_3546815_2 Sporulation and spore germination - - - 0.000000000000000000000000000000000000000000000000000051 198.0
TLS2_k127_3546815_3 Universal stress protein family - - - 0.0000000000000000000000000000000000000000004035 171.0
TLS2_k127_357658_0 Metallopeptidase family M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 544.0
TLS2_k127_357658_1 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 491.0
TLS2_k127_357658_2 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 357.0
TLS2_k127_357658_3 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020,K00042 - 1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005982 296.0
TLS2_k127_357658_4 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 302.0
TLS2_k127_357658_5 PFAM dehydrogenase, E1 component K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 293.0
TLS2_k127_357658_6 Periplasmic binding protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000362 235.0
TLS2_k127_357658_7 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.000000000000000000000000000000000000000000000000000000003689 213.0
TLS2_k127_357658_8 Monosaccharide ABC transporter ATP-binding protein, CUT2 family K10441 - 3.6.3.17 0.0000000000004018 73.0
TLS2_k127_3672683_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004748 545.0
TLS2_k127_3672683_1 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 455.0
TLS2_k127_3672683_10 Putative ATP-dependant zinc protease - - - 0.000000000000000000000000000000000000007826 152.0
TLS2_k127_3672683_11 Peptidase family M50 - - - 0.0000000000000000000000317 110.0
TLS2_k127_3672683_12 Cupin domain - - - 0.00000000000000000007335 93.0
TLS2_k127_3672683_13 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000003574 80.0
TLS2_k127_3672683_14 transcriptional regulator - - - 0.0000000002194 70.0
TLS2_k127_3672683_2 Belongs to the RimK family K05827,K05844 - 6.3.2.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005007 428.0
TLS2_k127_3672683_3 Succinylglutamate desuccinylase aspartoacylase K06987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 350.0
TLS2_k127_3672683_4 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 321.0
TLS2_k127_3672683_5 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures K07503 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 302.0
TLS2_k127_3672683_6 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000000000000000004753 215.0
TLS2_k127_3672683_7 VanW like protein - - - 0.00000000000000000000000000000000000000000000000000007179 207.0
TLS2_k127_3672683_8 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000004478 178.0
TLS2_k127_3672683_9 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000001005 154.0
TLS2_k127_3686704_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1122.0
TLS2_k127_3686704_1 von Willebrand factor, type A K07114 - - 3.336e-249 823.0
TLS2_k127_3686704_10 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001054 271.0
TLS2_k127_3686704_11 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006768 270.0
TLS2_k127_3686704_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07032 - - 0.000000000000000000000000000000000000000000000000003759 190.0
TLS2_k127_3686704_13 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000005892 191.0
TLS2_k127_3686704_14 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000000000005126 186.0
TLS2_k127_3686704_15 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000007295 184.0
TLS2_k127_3686704_16 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000354 175.0
TLS2_k127_3686704_17 HNH endonuclease - - - 0.00000000000000000000000000000000000000001795 167.0
TLS2_k127_3686704_18 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000001797 148.0
TLS2_k127_3686704_19 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.0000000000000000000000002328 107.0
TLS2_k127_3686704_2 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 429.0
TLS2_k127_3686704_20 nuclear chromosome segregation - - - 0.00000000000000000001066 107.0
TLS2_k127_3686704_21 transglycosylase associated protein - - - 0.00000000000000001063 86.0
TLS2_k127_3686704_22 glyoxalase III activity - - - 0.00000004438 62.0
TLS2_k127_3686704_23 Dodecin K09165 - - 0.00006125 48.0
TLS2_k127_3686704_3 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 429.0
TLS2_k127_3686704_4 associated with various cellular activities K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 372.0
TLS2_k127_3686704_5 protein methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007473 351.0
TLS2_k127_3686704_6 D-alanyl-D-alanine carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009756 297.0
TLS2_k127_3686704_7 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000448 277.0
TLS2_k127_3686704_8 -acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000819 264.0
TLS2_k127_3686704_9 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000341 269.0
TLS2_k127_36988_0 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 578.0
TLS2_k127_36988_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 410.0
TLS2_k127_36988_2 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 320.0
TLS2_k127_36988_3 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000396 292.0
TLS2_k127_36988_4 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.00000000000000000000000000000000000000000000000005934 183.0
TLS2_k127_36988_5 LytR cell envelope-related transcriptional attenuator - - - 0.000000000000000000000000001182 126.0
TLS2_k127_36988_6 NUDIX domain - - - 0.0000000000000000000000002772 111.0
TLS2_k127_36988_7 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000005155 106.0
TLS2_k127_36988_8 CAAX protease self-immunity K07052 - - 0.000000000265 70.0
TLS2_k127_3744596_0 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003353 431.0
TLS2_k127_3744596_1 Amino acid amide ABC transporter ATP-binding protein 1, HAAT family K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004012 338.0
TLS2_k127_3744596_2 Amino acid amide ABC transporter ATP-binding protein 2, HAAT family K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 334.0
TLS2_k127_3744596_3 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000001163 217.0
TLS2_k127_3744596_4 Permease - - - 0.0000000000000000000000000000000000001205 158.0
TLS2_k127_3747729_0 beta-1,4-mannooligosaccharide phosphorylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007998 442.0
TLS2_k127_3747729_1 Divalent cation transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000131 287.0
TLS2_k127_3747729_10 Universal stress protein - - - 0.00000000000000003286 88.0
TLS2_k127_3747729_11 - - - - 0.000000004872 65.0
TLS2_k127_3747729_2 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005643 275.0
TLS2_k127_3747729_3 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009386 266.0
TLS2_k127_3747729_4 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001282 268.0
TLS2_k127_3747729_5 Phosphoribosyl transferase domain K07100 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000006848 203.0
TLS2_k127_3747729_6 response regulator - - - 0.0000000000000000000000000000000000000000000005671 173.0
TLS2_k127_3747729_7 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000002855 179.0
TLS2_k127_3747729_8 Histidine kinase - - - 0.000000000000000000000000000000000000000000008289 181.0
TLS2_k127_3747729_9 menaquinone-dependent protoporphyrinogen oxidase activity K00230 - 1.3.5.3 0.0000000000000000000000000000000000000001727 156.0
TLS2_k127_3749476_0 Divalent cation transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 367.0
TLS2_k127_3749476_1 Bacterial regulatory protein, arsR family - - - 0.000000000000000000004116 97.0
TLS2_k127_3749476_2 Transcriptional regulator, arsR - - - 0.0000000000000004028 84.0
TLS2_k127_3749476_3 Rhodanese Homology Domain - - - 0.000000000000001636 79.0
TLS2_k127_3749476_4 CAAX protease self-immunity - - - 0.000005305 53.0
TLS2_k127_3753334_0 Domain of unknown function (DUF4389) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 423.0
TLS2_k127_3753334_1 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007574 285.0
TLS2_k127_3753334_2 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004555 273.0
TLS2_k127_3753334_3 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005823 265.0
TLS2_k127_3753334_4 Short repeat of unknown function (DUF308) - - - 0.0000000000000000000000000000000000000000000000003176 182.0
TLS2_k127_3753334_5 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000000000001052 145.0
TLS2_k127_3756714_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K19312 GO:0003674,GO:0003824,GO:0004658,GO:0016421,GO:0016874,GO:0016885 2.1.3.15,6.4.1.2,6.4.1.3 3.216e-210 663.0
TLS2_k127_3756714_1 UDP binding domain K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003283 390.0
TLS2_k127_3756714_2 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007533 276.0
TLS2_k127_3756714_3 F420-0:Gamma-glutamyl ligase K12234 GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000008717 227.0
TLS2_k127_3756714_4 LytR cell envelope-related transcriptional attenuator - - - 0.000000000000000000000000000000000000000000001393 181.0
TLS2_k127_3756714_5 Glycosyltransferase like family 2 - - - 0.00000000000000000000000001463 128.0
TLS2_k127_3756714_6 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.000000000000000000002938 102.0
TLS2_k127_3756714_7 Carboxymethylenebutenolidase K01061 - 3.1.1.45 0.000000000000000000008264 103.0
TLS2_k127_3756714_8 Non-essential cell division protein that could be required for efficient cell constriction - - - 0.000000002693 70.0
TLS2_k127_3792344_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 5.161e-194 617.0
TLS2_k127_3792344_1 DNA polymerase beta thumb K02347 - - 5.968e-194 620.0
TLS2_k127_3792344_10 Type II secretion system K12510 - - 0.00008743 55.0
TLS2_k127_3792344_2 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 344.0
TLS2_k127_3792344_3 PFAM Type II secretion system protein E K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 306.0
TLS2_k127_3792344_4 HAD-superfamily subfamily IB hydrolase, TIGR01490 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000841 257.0
TLS2_k127_3792344_5 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000003379 195.0
TLS2_k127_3792344_6 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00991 - 2.7.7.60 0.000000000000000000000000000000001477 138.0
TLS2_k127_3792344_7 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000002172 127.0
TLS2_k127_3792344_8 F420H(2)-dependent quinone reductase - - - 0.000000000000000007267 89.0
TLS2_k127_379810_0 fructose-bisphosphate aldolase, class II, yeast E. coli subtype K01624 GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 430.0
TLS2_k127_379810_1 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 360.0
TLS2_k127_379810_2 PFAM oxidoreductase molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 345.0
TLS2_k127_379810_3 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 326.0
TLS2_k127_379810_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001232 252.0
TLS2_k127_379810_5 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000001738 233.0
TLS2_k127_379810_6 Protein of unknown function (DUF454) K09790 - - 0.00000000000002073 79.0
TLS2_k127_3805510_0 Transport of potassium into the cell K03549 - - 3.252e-214 682.0
TLS2_k127_3805510_1 OST-HTH/LOTUS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005511 439.0
TLS2_k127_3805510_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000000000005939 171.0
TLS2_k127_3805510_11 Redoxin K03386 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.00000000000000000000000000000000000007108 150.0
TLS2_k127_3805510_12 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000964 143.0
TLS2_k127_3805510_13 PFAM Glycosyl transferase, family 2 K11936 - - 0.0000000000000000000006033 101.0
TLS2_k127_3805510_14 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000000000114 100.0
TLS2_k127_3805510_15 SNARE associated Golgi protein - - - 0.0000000000000000006484 95.0
TLS2_k127_3805510_16 Hydrolase - - - 0.000000000000001058 89.0
TLS2_k127_3805510_17 - - - - 0.00000000000009921 79.0
TLS2_k127_3805510_18 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000004698 65.0
TLS2_k127_3805510_2 Protein of unknown function (DUF1298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 376.0
TLS2_k127_3805510_20 PFAM Colicin V production protein K03558 - - 0.0000000003592 71.0
TLS2_k127_3805510_21 - - - - 0.000000132 62.0
TLS2_k127_3805510_23 antisigma factor binding K03598 - - 0.00001571 57.0
TLS2_k127_3805510_24 DNA-templated transcription, initiation - - - 0.0002478 46.0
TLS2_k127_3805510_25 Recombinase - - - 0.0005938 46.0
TLS2_k127_3805510_3 Voltage gated chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 360.0
TLS2_k127_3805510_4 Threonyl and Alanyl tRNA synthetase second additional domain K07050 - - 0.00000000000000000000000000000000000000000000000000000000000000000002509 240.0
TLS2_k127_3805510_5 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000003443 230.0
TLS2_k127_3805510_6 Response regulator receiver domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000003133 224.0
TLS2_k127_3805510_7 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000005295 202.0
TLS2_k127_3805510_8 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000007167 197.0
TLS2_k127_3805510_9 PFAM ornithine cyclodeaminase mu-crystallin K01750 - 4.3.1.12 0.0000000000000000000000000000000000000000000000008548 185.0
TLS2_k127_3806177_0 ABC transporter K06147 - - 3.238e-279 873.0
TLS2_k127_3806177_1 ABC transporter transmembrane region K06147 - - 9.612e-242 760.0
TLS2_k127_3806177_10 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000003022 239.0
TLS2_k127_3806177_11 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000001289 169.0
TLS2_k127_3806177_12 HD domain - - - 0.000000000000000000000000000000000000000242 166.0
TLS2_k127_3806177_13 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase K01185,K02395,K19223 - 3.2.1.17 0.00000000000000000000000000000000144 143.0
TLS2_k127_3806177_14 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000002015 124.0
TLS2_k127_3806177_15 heme binding K21472 - - 0.0000000000000000000004367 109.0
TLS2_k127_3806177_16 - - - - 0.00000000000000000000274 105.0
TLS2_k127_3806177_17 Family of unknown function (DUF5317) - - - 0.000000001371 63.0
TLS2_k127_3806177_18 poly(R)-hydroxyalkanoic acid synthase subunit PhaC K03821 - - 0.0000006494 56.0
TLS2_k127_3806177_2 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 511.0
TLS2_k127_3806177_3 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 355.0
TLS2_k127_3806177_4 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007084 333.0
TLS2_k127_3806177_5 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 319.0
TLS2_k127_3806177_6 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 313.0
TLS2_k127_3806177_7 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 307.0
TLS2_k127_3806177_8 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000055 292.0
TLS2_k127_3806177_9 ABC-type cobalamin Fe3 -siderophore transport system, ATPase component K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000001228 258.0
TLS2_k127_3812228_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 5.614e-237 747.0
TLS2_k127_3812228_1 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006311 480.0
TLS2_k127_3812228_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 457.0
TLS2_k127_3812228_3 acetyltransferase component of pyruvate dehydrogenase complex K00627,K00658 - 2.3.1.12,2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 325.0
TLS2_k127_3812228_4 Transcriptional regulator K13652 - - 0.0000000000000000000000000000000000002909 145.0
TLS2_k127_3840529_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 335.0
TLS2_k127_3840529_1 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000001561 211.0
TLS2_k127_3840529_2 PFAM peptidase M50 K11749 GO:0008150,GO:0040007 - 0.00000000000000000000000000000000000000000000001305 181.0
TLS2_k127_3840529_3 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000001301 132.0
TLS2_k127_3840529_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000002791 82.0
TLS2_k127_3879007_0 PFAM AMP-dependent synthetase and ligase K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006849 528.0
TLS2_k127_3879007_1 TspO/MBR family K05770 - - 0.00000000000000000000000000000000000004387 149.0
TLS2_k127_3879007_2 Bacterial PH domain - - - 0.00000000000000000000000000000000000007841 151.0
TLS2_k127_3879007_3 - - - - 0.000001539 60.0
TLS2_k127_3881500_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003446 421.0
TLS2_k127_3881500_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001922 272.0
TLS2_k127_3881500_2 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000004789 226.0
TLS2_k127_3881500_3 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.0000000000000000000000000000000000000000557 158.0
TLS2_k127_3881500_4 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000003388 142.0
TLS2_k127_3881500_5 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000001132 141.0
TLS2_k127_3881500_6 Tetratricopeptide repeat - - - 0.000000000000000000001236 106.0
TLS2_k127_3881500_7 HNH nucleases - - - 0.00000000000000000005565 101.0
TLS2_k127_3881500_8 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.00000000004286 63.0
TLS2_k127_3881500_9 Evidence 5 No homology to any previously reported sequences - - - 0.00001763 53.0
TLS2_k127_3909233_0 Belongs to the GcvT family K00302 - 1.5.3.1 0.0 1226.0
TLS2_k127_3909233_1 homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 5.722e-285 900.0
TLS2_k127_3909233_10 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001646 261.0
TLS2_k127_3909233_11 histidinol-phosphate transaminase activity K00817,K01814 GO:0000105,GO:0003674,GO:0003824,GO:0004400,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0010038,GO:0010045,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000001559 271.0
TLS2_k127_3909233_12 Imidazoleglycerol-phosphate dehydratase K00817,K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,3.1.3.15,4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000195 249.0
TLS2_k127_3909233_13 Glutamine amidotransferase class-I K02501 - - 0.0000000000000000000000000000000000000000000000000002234 193.0
TLS2_k127_3909233_14 Sarcosine oxidase, delta subunit family K00304 - 1.5.3.1 0.00000000000000000000000008257 110.0
TLS2_k127_3909233_15 Belongs to the GcvT family K00302 - 1.5.3.1 0.000000000000000001583 97.0
TLS2_k127_3909233_16 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K00320 - 1.5.98.2 0.00002216 53.0
TLS2_k127_3909233_2 FAD dependent oxidoreductase K00303 - 1.5.3.1 8.361e-202 649.0
TLS2_k127_3909233_3 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 544.0
TLS2_k127_3909233_4 ThiF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 493.0
TLS2_k127_3909233_5 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 494.0
TLS2_k127_3909233_6 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 436.0
TLS2_k127_3909233_7 Histidinol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 402.0
TLS2_k127_3909233_8 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 335.0
TLS2_k127_3909233_9 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000929 287.0
TLS2_k127_3917202_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.747e-285 889.0
TLS2_k127_3917202_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 3.389e-223 701.0
TLS2_k127_3917202_10 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000004427 162.0
TLS2_k127_3917202_11 Protein of unknown function (DUF456) K09793 - - 0.00000000000000000000000000000001175 135.0
TLS2_k127_3917202_12 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.0000000000000000000000001616 113.0
TLS2_k127_3917202_13 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000001822 108.0
TLS2_k127_3917202_14 Psort location Cytoplasmic, score - - - 0.0000000000000007341 85.0
TLS2_k127_3917202_15 - - - - 0.000000000004702 76.0
TLS2_k127_3917202_2 metalloendopeptidase activity K01392,K01393 GO:0000209,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005829,GO:0005886,GO:0006109,GO:0006111,GO:0006464,GO:0006508,GO:0006518,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009987,GO:0010675,GO:0010830,GO:0010906,GO:0016020,GO:0016202,GO:0016567,GO:0016787,GO:0019222,GO:0019538,GO:0023052,GO:0031323,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032446,GO:0033218,GO:0034641,GO:0035556,GO:0036211,GO:0042277,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0048634,GO:0048641,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051147,GO:0051153,GO:0051239,GO:0051716,GO:0062012,GO:0065007,GO:0070011,GO:0070012,GO:0070013,GO:0070647,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564,GO:1901861,GO:1902809,GO:2000026,GO:2001014 3.4.24.15,3.4.24.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 477.0
TLS2_k127_3917202_3 Amidohydrolase family K01466 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000433 403.0
TLS2_k127_3917202_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008652 396.0
TLS2_k127_3917202_5 Allantoicase repeat K01477 - 3.5.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000006091 271.0
TLS2_k127_3917202_6 metal-dependent hydrolase with the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000005457 230.0
TLS2_k127_3917202_7 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.0000000000000000000000000000000000000000000000000000000000001111 224.0
TLS2_k127_3917202_8 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000009765 217.0
TLS2_k127_3917202_9 PFAM inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000002235 207.0
TLS2_k127_3943837_0 FAD binding domain - - - 5.116e-212 669.0
TLS2_k127_3943837_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 415.0
TLS2_k127_3943837_10 - - - - 0.00000000000006696 77.0
TLS2_k127_3943837_11 membrane - - - 0.00000001009 64.0
TLS2_k127_3943837_12 TM2 domain - - - 0.00001801 51.0
TLS2_k127_3943837_13 - - - - 0.000417 49.0
TLS2_k127_3943837_2 Flavin-binding monooxygenase-like K07222,K18277 - 1.14.13.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 333.0
TLS2_k127_3943837_3 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000689 325.0
TLS2_k127_3943837_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006712 312.0
TLS2_k127_3943837_5 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002026 289.0
TLS2_k127_3943837_6 - - - - 0.00000000000000000000000000000000000000000000001024 175.0
TLS2_k127_3943837_7 3-demethylubiquinone-9 3-O-methyltransferase activity K03428 - 2.1.1.11 0.00000000000000000000000000000000000000000004548 169.0
TLS2_k127_3943837_9 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18958 GO:0001101,GO:0008150,GO:0010033,GO:0033993,GO:0042221,GO:0046677,GO:0050896,GO:0070542,GO:1901700 - 0.0000000000000001079 83.0
TLS2_k127_3963603_0 Protein of unknown function (DUF1295) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006932 333.0
TLS2_k127_3963603_1 Cupin domain K08641,K11312 - 3.4.13.22 0.00000000000000000000000000000000000000000000000000002784 195.0
TLS2_k127_3963603_10 HEPN domain - - - 0.000000000001824 73.0
TLS2_k127_3963603_11 Transcriptional regulatory protein, C terminal - - - 0.0000000000137 76.0
TLS2_k127_3963603_12 tape measure protein - - - 0.00000000001592 78.0
TLS2_k127_3963603_14 - - - - 0.000001464 51.0
TLS2_k127_3963603_15 belongs to the sigma-70 factor family, ECF subfamily - - - 0.0003516 49.0
TLS2_k127_3963603_16 - - - - 0.0006163 49.0
TLS2_k127_3963603_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000001835 195.0
TLS2_k127_3963603_3 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000001297 140.0
TLS2_k127_3963603_4 BNR Asp-box repeat K01186 - 3.2.1.18 0.0000000000000000000000000000000009211 151.0
TLS2_k127_3963603_5 sequence-specific DNA binding - - - 0.00000000000000000000000000002448 122.0
TLS2_k127_3963603_7 Nucleotidyltransferase domain - - - 0.0000000000000000001077 96.0
TLS2_k127_3963603_9 FR47-like protein - - - 0.00000000000000004357 91.0
TLS2_k127_3966698_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003433 597.0
TLS2_k127_3966698_1 amino acid ABC transporter, ATP-binding protein K02028,K17076 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 357.0
TLS2_k127_3966698_2 amino acid transport K09969 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 314.0
TLS2_k127_3966698_3 ABC transporter K02029,K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 287.0
TLS2_k127_3966698_4 Transcriptional regulatory protein, C terminal K07776 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004107 265.0
TLS2_k127_3966698_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000002149 260.0
TLS2_k127_3966698_6 Belongs to the bacterial solute-binding protein 3 family K02030 - - 0.00000000000000000000000000000000000000000000000000000004379 208.0
TLS2_k127_3966698_7 acetyltransferase - - - 0.0000000000000000000000000003433 124.0
TLS2_k127_3966722_0 Alpha/beta-hydrolase family N-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 617.0
TLS2_k127_3966722_1 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 312.0
TLS2_k127_3966722_2 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000008612 225.0
TLS2_k127_3966722_3 - - - - 0.0000000004824 72.0
TLS2_k127_3984285_0 Molybdopterin oxidoreductase K00123 - 1.17.1.9 3.228e-238 747.0
TLS2_k127_3984285_1 FAD dependent oxidoreductase - - - 4.642e-197 624.0
TLS2_k127_3984285_10 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007738 344.0
TLS2_k127_3984285_11 COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain K00544,K00548 - 2.1.1.13,2.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008029 324.0
TLS2_k127_3984285_12 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003012 258.0
TLS2_k127_3984285_13 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004236 246.0
TLS2_k127_3984285_14 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000009334 188.0
TLS2_k127_3984285_15 Phospholipid methyltransferase - - - 0.000000000000000000000000000000000000000000000000001775 195.0
TLS2_k127_3984285_16 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000808 138.0
TLS2_k127_3984285_17 ABC-type proline glycine betaine transport system, permease component K05845,K05846 - - 0.0000000000000000000000000004069 116.0
TLS2_k127_3984285_18 Molybdopterin oxidoreductase - - - 0.00000000000000000000000006428 108.0
TLS2_k127_3984285_19 Protein conserved in bacteria - - - 0.00000000000000001215 94.0
TLS2_k127_3984285_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00122,K00335 - 1.17.1.9,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002696 604.0
TLS2_k127_3984285_20 hydrolase (metallo-beta-lactamase superfamily) - - - 0.000000004403 69.0
TLS2_k127_3984285_3 trimethylamine methyltransferase K14083 - 2.1.1.250 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003903 567.0
TLS2_k127_3984285_4 mandelate racemase muconate lactonizing - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004825 533.0
TLS2_k127_3984285_5 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 441.0
TLS2_k127_3984285_6 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 437.0
TLS2_k127_3984285_7 2Fe-2S iron-sulfur cluster binding domain K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 404.0
TLS2_k127_3984285_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 396.0
TLS2_k127_3984285_9 alcohol dehydrogenase K00001,K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000576 367.0
TLS2_k127_3985127_0 malic enzyme K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 5.544e-229 727.0
TLS2_k127_3985127_1 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008135 621.0
TLS2_k127_3985127_10 Phosphoglycerate mutase family - - - 0.000000000000000000000000000000000003301 144.0
TLS2_k127_3985127_11 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000615 149.0
TLS2_k127_3985127_12 PspA/IM30 family K03969 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044464,GO:0071944 - 0.00000000000000000000000003367 117.0
TLS2_k127_3985127_13 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000003781 106.0
TLS2_k127_3985127_14 - - - - 0.00003188 47.0
TLS2_k127_3985127_15 DNA-binding helix-turn-helix protein - - - 0.0005072 51.0
TLS2_k127_3985127_2 Glycosyltransferase family 28 C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 468.0
TLS2_k127_3985127_3 Cysteine synthase K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 399.0
TLS2_k127_3985127_4 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 332.0
TLS2_k127_3985127_5 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000009233 249.0
TLS2_k127_3985127_6 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000006966 226.0
TLS2_k127_3985127_7 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000001952 204.0
TLS2_k127_3985127_8 MerR, DNA binding K13639 - - 0.0000000000000000000000000000000000000000000000000001218 192.0
TLS2_k127_3985127_9 - - - - 0.0000000000000000000000000000000000005218 146.0
TLS2_k127_399483_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1238.0
TLS2_k127_399483_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 553.0
TLS2_k127_399483_10 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02045,K06857,K11072 - 3.6.3.25,3.6.3.31,3.6.3.55 0.000000000005141 66.0
TLS2_k127_399483_11 Protein of unknown function (DUF2752) - - - 0.0000000003885 65.0
TLS2_k127_399483_12 Family of unknown function (DUF5317) - - - 0.000000001188 69.0
TLS2_k127_399483_2 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008754 409.0
TLS2_k127_399483_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 313.0
TLS2_k127_399483_4 PFAM FAD dependent oxidoreductase K09471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004398 280.0
TLS2_k127_399483_5 enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000008676 218.0
TLS2_k127_399483_6 Beta-lactamase class A - - - 0.000000000000000000000000000000000000000000000000000001372 209.0
TLS2_k127_399483_7 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.000000000000000000000000000192 127.0
TLS2_k127_399483_8 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000009123 120.0
TLS2_k127_399483_9 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.0000000000000000000000002772 111.0
TLS2_k127_3997084_0 ABC transporter - - - 2.806e-298 922.0
TLS2_k127_3997084_1 PFAM Activator of Hsp90 ATPase 1 family protein - - - 0.00000000000000000000000000000000000000000005414 165.0
TLS2_k127_3997084_2 MarR family transcriptional regulator - - - 0.000000000000000000000000000000001334 136.0
TLS2_k127_3997084_3 pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000248 119.0
TLS2_k127_3997084_4 Haemolysin-III related K11068 - - 0.000000000000000000000262 104.0
TLS2_k127_3997084_5 ABC transporter substrate-binding protein K02016 - - 0.00000000001553 70.0
TLS2_k127_3997084_6 PFAM periplasmic binding protein K02016 - - 0.00000000006321 67.0
TLS2_k127_3997084_7 Periplasmic binding protein K02016 - - 0.00000006116 60.0
TLS2_k127_3997084_8 PFAM periplasmic binding protein K02016 - - 0.0003034 50.0
TLS2_k127_4002759_0 COG2015 Alkyl sulfatase and related hydrolases - - - 1.149e-208 662.0
TLS2_k127_4002759_1 Sulfate permease family K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 415.0
TLS2_k127_4002759_2 Sulfate permease family K03321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 373.0
TLS2_k127_4002759_3 Sodium Bile acid symporter family K03453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000711 289.0
TLS2_k127_4002759_4 chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000002321 229.0
TLS2_k127_4002759_5 helix_turn_helix, Lux Regulon K03556 - - 0.000000000000004942 77.0
TLS2_k127_4007275_0 PFAM regulatory protein LuxR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 434.0
TLS2_k127_4007275_1 - - - - 0.00000000000000000000001042 118.0
TLS2_k127_4007275_2 Histidine kinase - - - 0.000000000000000006095 94.0
TLS2_k127_4007275_3 - - - - 0.0000006511 57.0
TLS2_k127_4024856_0 Na H antiporter K05565,K14086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 591.0
TLS2_k127_4024856_1 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 484.0
TLS2_k127_4024856_10 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000004394 188.0
TLS2_k127_4024856_11 Pfam:Pyridox_oxidase - GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0030312,GO:0031406,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 - 0.00000000000000000000000000000000000000008417 154.0
TLS2_k127_4024856_12 PFAM NADH-ubiquinone oxidoreductase chain 4L K05567 - - 0.000000000000000000000000000000000000001745 153.0
TLS2_k127_4024856_13 sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000009215 148.0
TLS2_k127_4024856_14 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K05565,K14086 - - 0.00000000000000000000000000000000006528 138.0
TLS2_k127_4024856_15 signal transduction Histidine kinase - - - 0.00000000000000000000000000000149 136.0
TLS2_k127_4024856_16 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000007439 123.0
TLS2_k127_4024856_17 Na+/H+ antiporter subunit K05571 - - 0.00000000000000000005445 97.0
TLS2_k127_4024856_18 multisubunit Na H antiporter MnhE subunit K05569 - - 0.000000000000002086 83.0
TLS2_k127_4024856_19 antiporter activity K05570 - - 0.000000000001507 74.0
TLS2_k127_4024856_2 PFAM NADH Ubiquinone plastoquinone (complex I) K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 452.0
TLS2_k127_4024856_20 SnoaL-like domain - - - 0.00000000001106 66.0
TLS2_k127_4024856_22 synthase K01719 - 4.2.1.75 0.0000000948 64.0
TLS2_k127_4024856_23 Belongs to the universal stress protein A family - - - 0.0005335 50.0
TLS2_k127_4024856_3 PFAM delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008505 396.0
TLS2_k127_4024856_4 binding-protein-dependent transport systems inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 370.0
TLS2_k127_4024856_5 Coproporphyrinogen III oxidase K00228 - 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004171 328.0
TLS2_k127_4024856_6 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006553 317.0
TLS2_k127_4024856_7 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 299.0
TLS2_k127_4024856_8 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000001575 220.0
TLS2_k127_4024856_9 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000003658 217.0
TLS2_k127_4040261_0 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 287.0
TLS2_k127_4040261_1 Glycerol acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000109 291.0
TLS2_k127_4040261_10 Sigma-70, region 4 - - - 0.0000000000000000000000008489 109.0
TLS2_k127_4040261_11 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.0000000000000000000000111 103.0
TLS2_k127_4040261_12 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000005295 101.0
TLS2_k127_4040261_13 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000005468 84.0
TLS2_k127_4040261_14 glyoxalase - - - 0.00000051 59.0
TLS2_k127_4040261_2 Truncated hemoglobins K06886 - - 0.000000000000000000000000000000000000000000000000000000000000008163 218.0
TLS2_k127_4040261_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000002616 208.0
TLS2_k127_4040261_4 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000001009 204.0
TLS2_k127_4040261_5 - - - - 0.00000000000000000000000000000000000000000000000000000423 194.0
TLS2_k127_4040261_6 - - - - 0.0000000000000000000000000000000000000000004131 165.0
TLS2_k127_4040261_7 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000007456 166.0
TLS2_k127_4040261_8 - - - - 0.000000000000000000000000000000000000000003437 162.0
TLS2_k127_4040261_9 SnoaL-like domain - - - 0.00000000000000000000000000003076 120.0
TLS2_k127_4042697_0 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007623 418.0
TLS2_k127_4042697_1 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006143 261.0
TLS2_k127_4042697_2 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000001141 230.0
TLS2_k127_4042697_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000006014 209.0
TLS2_k127_4042697_4 Hydrolase, TatD family K03424 - - 0.0000000000000000000000000000000000000000000002175 178.0
TLS2_k127_4042697_5 Zn peptidase - - - 0.0000000000000000000000000000000000000134 160.0
TLS2_k127_4042697_6 conserved protein, contains double-stranded beta-helix domain - - - 0.000000000000000000000000000000002907 136.0
TLS2_k127_4042697_7 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000001219 110.0
TLS2_k127_4042697_8 Transcriptional regulator, AbrB family K06284 - - 0.0000000000000000227 85.0
TLS2_k127_4074416_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 2.321e-203 657.0
TLS2_k127_4074416_1 Isocitrate/isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005672 445.0
TLS2_k127_4074416_2 Glycerol acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002224 289.0
TLS2_k127_4074416_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000009699 230.0
TLS2_k127_4074416_4 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000004907 160.0
TLS2_k127_4080354_0 Belongs to the Glu Leu Phe Val dehydrogenases family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 504.0
TLS2_k127_4080354_1 Protein of unknown function (DUF2800) K07465 - - 0.000000000000000000000000000000000000000000000000000006823 203.0
TLS2_k127_4080354_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000002093 163.0
TLS2_k127_4080354_3 Belongs to the helicase family. UvrD subfamily - - - 0.000000000000000000009966 100.0
TLS2_k127_4131739_0 Heat shock 70 kDa protein K04043 - - 9.562e-263 822.0
TLS2_k127_4131739_1 N-4 methylation of cytosine K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 394.0
TLS2_k127_4131739_10 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000002829 108.0
TLS2_k127_4131739_11 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000185 106.0
TLS2_k127_4131739_12 acetyltransferase K09181 - - 0.00000000001952 73.0
TLS2_k127_4131739_13 MT0933-like antitoxin protein - - - 0.000000000165 64.0
TLS2_k127_4131739_2 COG4335 DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 371.0
TLS2_k127_4131739_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 363.0
TLS2_k127_4131739_4 isomerase activity - - - 0.000000000000000000000000000000000000000000000000000000001148 212.0
TLS2_k127_4131739_5 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000006604 200.0
TLS2_k127_4131739_6 DoxX K15977 - - 0.000000000000000000000000000000000000005661 151.0
TLS2_k127_4131739_7 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000001945 127.0
TLS2_k127_4131739_8 helix_turn_helix, mercury resistance K13640 - - 0.00000000000000000000000000003506 120.0
TLS2_k127_4131739_9 - - - - 0.00000000000000000000000008004 118.0
TLS2_k127_4156170_0 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006944 614.0
TLS2_k127_4156170_1 GXGXG motif K00265 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008963 550.0
TLS2_k127_4156170_10 - - - - 0.00000000000001571 80.0
TLS2_k127_4156170_11 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000687 73.0
TLS2_k127_4156170_12 Pfam:Pyridox_oxidase K07005 - - 0.0000958 51.0
TLS2_k127_4156170_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002301 284.0
TLS2_k127_4156170_3 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000004325 250.0
TLS2_k127_4156170_4 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000001304 222.0
TLS2_k127_4156170_5 Ribonuclease III family K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000007382 213.0
TLS2_k127_4156170_6 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000002385 160.0
TLS2_k127_4156170_7 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000001055 100.0
TLS2_k127_4156170_8 acylphosphatase activity K01512 GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 0.00000000000000001279 87.0
TLS2_k127_4156170_9 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000002403 82.0
TLS2_k127_4167031_0 Flavin containing amine oxidoreductase - - - 6.85e-252 785.0
TLS2_k127_4167031_1 Glycine cleavage T-protein C-terminal barrel domain K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 447.0
TLS2_k127_4167031_2 Peptidase S15 K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 450.0
TLS2_k127_4167031_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005988 383.0
TLS2_k127_4167031_4 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00479 - - 0.00000000000000000000000000000000000000000000000000000000000000102 225.0
TLS2_k127_4167031_5 ATP- GTP-binding protein - - - 0.000000000000000000000000000000000000000000000000008635 184.0
TLS2_k127_4167031_6 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000002598 155.0
TLS2_k127_4167031_7 Domain of unknown function (DUF1905) - - - 0.000000000000000000000000000000000002772 139.0
TLS2_k127_4167031_8 repeat protein - - - 0.0000000000004087 75.0
TLS2_k127_4182527_0 Acyl-CoA dehydrogenase N terminal K20035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 610.0
TLS2_k127_4182527_1 PFAM Cys Met metabolism pyridoxal-phosphate- dependent protein K01739,K01758,K01761 - 2.5.1.48,4.4.1.1,4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000463 426.0
TLS2_k127_4182527_2 PFAM short chain dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008268 276.0
TLS2_k127_4182527_3 Sir2 family K12410 - - 0.000000000000000000000000000000000000000000000000000000001442 211.0
TLS2_k127_4182527_4 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000005837 186.0
TLS2_k127_4182527_5 Phosphoserine phosphatase - - - 0.0000000000000001707 84.0
TLS2_k127_4290839_0 TIGRFAM phenylacetate-CoA oxygenase, PaaG subunit K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007009 499.0
TLS2_k127_4290839_1 chorismate mutase K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007046 494.0
TLS2_k127_4290839_2 PFAM lactate malate dehydrogenase, alpha beta C-terminal domain K00016 - 1.1.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 394.0
TLS2_k127_4290839_3 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000003738 180.0
TLS2_k127_4290839_4 Phenylacetic acid degradation B K02610 - - 0.000000000000000000000000008733 111.0
TLS2_k127_4305127_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 385.0
TLS2_k127_4305127_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001633 256.0
TLS2_k127_4305127_2 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000002219 153.0
TLS2_k127_4305127_3 CAAX protease self-immunity - - - 0.00000000000000000000004643 111.0
TLS2_k127_4305127_4 metal-dependent membrane protease - - - 0.0000000000000000000006655 106.0
TLS2_k127_4305127_5 helix_turn_helix, Lux Regulon K07693 - - 0.00000002786 55.0
TLS2_k127_4305127_6 - - - - 0.0004026 45.0
TLS2_k127_4309595_0 Adenylate cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003864 601.0
TLS2_k127_4309595_1 lysozyme activity K07273 - - 0.0000000000000000000000000000000000000000001872 164.0
TLS2_k127_4309595_2 Histidine kinase - - - 0.000000000000000000000000006293 124.0
TLS2_k127_4309595_3 response regulator - - - 0.00000000000004363 77.0
TLS2_k127_4343556_0 MMPL family K06994 - - 2.253e-288 904.0
TLS2_k127_4343556_1 Major Facilitator Superfamily K18833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 466.0
TLS2_k127_4343556_10 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000001633 144.0
TLS2_k127_4343556_12 pyridoxamine-phosphate oxidase activity K00275 - 1.4.3.5 0.000000004458 61.0
TLS2_k127_4343556_13 TIGRFAM acetylornithine deacetylase or succinyl- diaminopimelate desuccinylase K01439 - 3.5.1.18 0.0004132 44.0
TLS2_k127_4343556_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 429.0
TLS2_k127_4343556_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004491 401.0
TLS2_k127_4343556_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003097 349.0
TLS2_k127_4343556_5 Two component transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 332.0
TLS2_k127_4343556_6 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005579 310.0
TLS2_k127_4343556_7 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 289.0
TLS2_k127_4343556_8 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000008576 194.0
TLS2_k127_4343556_9 Putative stress-induced transcription regulator - - - 0.0000000000000000000000000000000000000000000000000000232 194.0
TLS2_k127_4348599_0 C4-dicarboxylate anaerobic carrier - - - 3.547e-235 736.0
TLS2_k127_4348599_1 major facilitator superfamily - - - 2.68e-218 689.0
TLS2_k127_4348599_2 Amidinotransferase K01478 - 3.5.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009405 536.0
TLS2_k127_4348599_3 Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the stringent response , an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 528.0
TLS2_k127_4348599_4 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 498.0
TLS2_k127_4348599_5 Putative threonine/serine exporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003941 320.0
TLS2_k127_4348599_6 Amino acid permease - - - 0.00000000000001008 75.0
TLS2_k127_4348599_7 - - - - 0.0000000006524 67.0
TLS2_k127_4376200_0 E1-E2 ATPase K12952 - - 3.948e-233 747.0
TLS2_k127_4376200_1 Creatinase/Prolidase N-terminal domain K01271,K15783 - 3.4.13.9,3.5.4.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008218 490.0
TLS2_k127_4376200_10 ABC-type sugar transport system, permease component K02026 - - 0.000000000000000000000000000000000000000000000000000000005585 221.0
TLS2_k127_4376200_11 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000005486 194.0
TLS2_k127_4376200_12 oxidoreductase - - - 0.000000000000000000000000000000000000000000000001773 187.0
TLS2_k127_4376200_13 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000002706 177.0
TLS2_k127_4376200_14 transcriptional regulator - - - 0.000000000000000000000000000000000000001044 155.0
TLS2_k127_4376200_15 PFAM amidohydrolase 2 K03392 - 4.1.1.45 0.0000000000000000000000000000813 123.0
TLS2_k127_4376200_16 Bacterial extracellular solute-binding protein K02027 - - 0.00000000001559 77.0
TLS2_k127_4376200_2 secondary active sulfate transmembrane transporter activity K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 409.0
TLS2_k127_4376200_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006509 416.0
TLS2_k127_4376200_4 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007468 322.0
TLS2_k127_4376200_5 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 310.0
TLS2_k127_4376200_6 CoA binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 316.0
TLS2_k127_4376200_7 Belongs to the HpcH HpaI aldolase family K01630,K02510 - 4.1.2.20,4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 303.0
TLS2_k127_4376200_8 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K16843 - 1.1.1.310 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006431 279.0
TLS2_k127_4376200_9 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000321 265.0
TLS2_k127_4440917_0 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 491.0
TLS2_k127_4440917_1 L-carnitine dehydratase bile acid-inducible protein F K01796 - 5.1.99.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007234 443.0
TLS2_k127_4440917_10 Thioesterase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000426 193.0
TLS2_k127_4440917_11 MOSC domain - - - 0.000000000000000000000000000000000000000000000007251 177.0
TLS2_k127_4440917_12 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000000000000000000005438 177.0
TLS2_k127_4440917_13 iron-sulfur cluster assembly K07400 - - 0.00000000000000000000000000000000000000002915 162.0
TLS2_k127_4440917_14 ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000000000000001517 159.0
TLS2_k127_4440917_15 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.000000000000000000000000000000000000003822 166.0
TLS2_k127_4440917_16 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.0000000000000000000000000000000000596 143.0
TLS2_k127_4440917_17 Probable molybdopterin binding domain - - - 0.000000000000000000000000000000001106 144.0
TLS2_k127_4440917_18 PFAM extracellular solute-binding protein, family 5 - - - 0.000000000000000000000000000000003884 136.0
TLS2_k127_4440917_19 PFAM Thiamin pyrophosphokinase, catalytic region K00949 - 2.7.6.2 0.00000000000000000000000005336 115.0
TLS2_k127_4440917_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 367.0
TLS2_k127_4440917_20 PFAM blue (type 1) copper domain protein - - - 0.00003763 52.0
TLS2_k127_4440917_3 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K15893 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004721 338.0
TLS2_k127_4440917_4 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003694 323.0
TLS2_k127_4440917_5 Right handed beta helix region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003481 319.0
TLS2_k127_4440917_6 dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005755 292.0
TLS2_k127_4440917_7 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000713 263.0
TLS2_k127_4440917_8 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.000000000000000000000000000000000000000000000000000000000000000000345 243.0
TLS2_k127_4440917_9 dihydrofolate reductase activity - - - 0.000000000000000000000000000000000000000000000000000000000003946 214.0
TLS2_k127_4442090_0 transporter K12942 - - 1.283e-206 657.0
TLS2_k127_4442090_1 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 580.0
TLS2_k127_4442090_10 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000007458 188.0
TLS2_k127_4442090_11 Roadblock/LC7 domain K07131 - - 0.0000000000000000000000000000002993 127.0
TLS2_k127_4442090_12 - - - - 0.0000000000000000000000001914 115.0
TLS2_k127_4442090_13 Ion channel - - - 0.00000000000000000000775 101.0
TLS2_k127_4442090_14 FR47-like protein - - - 0.0000000000000000001645 102.0
TLS2_k127_4442090_15 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.0000000000000003971 91.0
TLS2_k127_4442090_16 Protein of unknown function (DUF742) - - - 0.000000000005452 77.0
TLS2_k127_4442090_17 META domain - - - 0.0000000003288 66.0
TLS2_k127_4442090_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 528.0
TLS2_k127_4442090_3 Cytosol aminopeptidase family, catalytic domain K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 500.0
TLS2_k127_4442090_4 PFAM FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006094 488.0
TLS2_k127_4442090_5 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000567 369.0
TLS2_k127_4442090_6 PFAM Transketolase central region K00167 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006303 365.0
TLS2_k127_4442090_7 integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 349.0
TLS2_k127_4442090_8 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004942 330.0
TLS2_k127_4442090_9 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000001429 243.0
TLS2_k127_4455756_0 ATPase MipZ K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 344.0
TLS2_k127_4455756_1 ParB-like nuclease domain K03497 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000135 251.0
TLS2_k127_4455756_10 Ribonuclease P - - - 0.0000001865 59.0
TLS2_k127_4455756_2 Cell wall hydrolase autolysin K01448 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 0.00000000000000000000000000000000000003398 156.0
TLS2_k127_4455756_3 ferredoxin-NADP+ reductase activity K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000003799 127.0
TLS2_k127_4455756_4 Putative single-stranded nucleic acids-binding domain K06346 - - 0.0000000000000000000000000000007486 133.0
TLS2_k127_4455756_5 Membrane protein insertase, YidC Oxa1 family K03217 - - 0.00000000000000000000000000000906 129.0
TLS2_k127_4455756_6 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000142 121.0
TLS2_k127_4455756_7 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000002487 111.0
TLS2_k127_4455756_8 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.00000000000000003643 89.0
TLS2_k127_4455756_9 Ribosomal protein L34 K02914 - - 0.000000001513 59.0
TLS2_k127_4465226_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 1.065e-201 646.0
TLS2_k127_4465226_1 elongation factor G K02355 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 563.0
TLS2_k127_4465226_2 Belongs to the citrate synthase family K01647 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 540.0
TLS2_k127_4465226_3 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 464.0
TLS2_k127_4465226_4 protein conserved in bacteria - - - 0.000000000000000000000000000001275 125.0
TLS2_k127_4465226_5 - - - - 0.0000000000000000001997 94.0
TLS2_k127_4465226_6 PFAM Patatin - - - 0.0000000000000001063 91.0
TLS2_k127_4465226_7 - - - - 0.00000000000002078 80.0
TLS2_k127_4465226_8 Phosphotransferase enzyme family - - - 0.0007406 50.0
TLS2_k127_4535595_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.709e-207 658.0
TLS2_k127_4535595_1 Biotin carboxylase C-terminal domain K11263 - 6.3.4.14,6.4.1.2,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 559.0
TLS2_k127_4535595_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 485.0
TLS2_k127_4535595_3 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 377.0
TLS2_k127_4535595_4 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005029 389.0
TLS2_k127_4535595_5 Protein of unknown function (DUF559) - - - 0.00000000000000000000000008844 119.0
TLS2_k127_4676966_0 Two component transcriptional regulator, LuxR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002422 259.0
TLS2_k127_4676966_1 Type II/IV secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000005798 242.0
TLS2_k127_4676966_10 - - - - 0.0000000851 61.0
TLS2_k127_4676966_11 Helix-turn-helix domain - - - 0.000007835 51.0
TLS2_k127_4676966_12 TadE-like protein - - - 0.0003824 50.0
TLS2_k127_4676966_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000009045 203.0
TLS2_k127_4676966_4 Protein of unknown function (DUF2587) - GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 - 0.00000000000000000000000000000001163 133.0
TLS2_k127_4676966_5 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.0000000000000000000000000006318 115.0
TLS2_k127_4676966_6 Type II secretion system K12510 - - 0.0000000000000000000000000145 121.0
TLS2_k127_4676966_7 Type II secretion system K12511 - - 0.000000000000006507 87.0
TLS2_k127_4676966_8 bacterial-type flagellum organization - - - 0.0000000000002069 82.0
TLS2_k127_4676966_9 Membrane - - - 0.000000000001611 76.0
TLS2_k127_4682201_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 2.275e-247 787.0
TLS2_k127_4682201_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 546.0
TLS2_k127_4682201_10 Protein conserved in bacteria - - - 0.000000003354 63.0
TLS2_k127_4682201_2 Belongs to the HpcH HpaI aldolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 473.0
TLS2_k127_4682201_3 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 456.0
TLS2_k127_4682201_4 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K01488 GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 406.0
TLS2_k127_4682201_5 AIR synthase related protein, C-terminal domain K01933 GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016882,GO:0044424,GO:0044444,GO:0044464 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000007713 271.0
TLS2_k127_4682201_6 thiolester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008091 253.0
TLS2_k127_4682201_7 CO dehydrogenase flavoprotein C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004548 234.0
TLS2_k127_4682201_8 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000002298 175.0
TLS2_k127_4682201_9 Metal-dependent hydrolase - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 - 0.000000000000000000000000000000000000000005215 162.0
TLS2_k127_469764_0 topoisomerase K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005112 291.0
TLS2_k127_469764_1 Helix-hairpin-helix domain K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000004625 244.0
TLS2_k127_469764_2 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.0000000000000000000000000000000000000000000000004876 187.0
TLS2_k127_469764_3 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000000008129 160.0
TLS2_k127_469764_4 Protein of unknown function (DUF421) - - - 0.0000000000000000000000000000000000004888 148.0
TLS2_k127_469764_5 - - - - 0.0000000000000000000006715 102.0
TLS2_k127_469764_6 Anti-sigma-K factor rskA - - - 0.000000001048 68.0
TLS2_k127_469764_7 Belongs to the anti-sigma-factor antagonist family - - - 0.00000004345 61.0
TLS2_k127_4707605_0 Belongs to the peptidase S8 family - - - 5.753e-307 969.0
TLS2_k127_4707605_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 2.683e-230 724.0
TLS2_k127_4707605_10 Glycoprotease family K14742 GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000002618 155.0
TLS2_k127_4707605_11 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000004175 133.0
TLS2_k127_4707605_12 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06925 GO:0008150,GO:0040007 - 0.00000000000000000000000000002271 128.0
TLS2_k127_4707605_13 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.000000000000000000000000005493 124.0
TLS2_k127_4707605_14 - - - - 0.000000000000000000000007648 109.0
TLS2_k127_4707605_15 biosynthesis protein K08252,K16692 - 2.7.10.1 0.00000000000000000005342 105.0
TLS2_k127_4707605_16 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000003127 96.0
TLS2_k127_4707605_17 - - - - 0.000000000000000003256 91.0
TLS2_k127_4707605_18 Phage integrase family - - - 0.000000000001298 81.0
TLS2_k127_4707605_19 -O-antigen - - - 0.00000005169 66.0
TLS2_k127_4707605_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006585 335.0
TLS2_k127_4707605_20 - - - - 0.0004512 44.0
TLS2_k127_4707605_3 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 306.0
TLS2_k127_4707605_4 Peptidase family M48 K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001205 277.0
TLS2_k127_4707605_5 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005369 256.0
TLS2_k127_4707605_6 PFAM peptidase S58 DmpA - - - 0.00000000000000000000000000000000000000000000000000000000000002998 226.0
TLS2_k127_4707605_7 Uracil-DNA glycosylase, family 4 K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000005677 211.0
TLS2_k127_4707605_8 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000471 204.0
TLS2_k127_4707605_9 acr, cog1565 - - - 0.000000000000000000000000000000000000000000002176 183.0
TLS2_k127_4729754_0 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 302.0
TLS2_k127_4729754_1 acetylesterase activity - - - 0.0000000000000000000000000000000000000000000000003465 200.0
TLS2_k127_4729754_2 Dienelactone hydrolase and related enzymes - - - 0.00000000000000000000000000000000001811 146.0
TLS2_k127_4729754_3 lysozyme activity K07273 - - 0.0000000000000004143 83.0
TLS2_k127_4734691_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.7.8 2.476e-232 747.0
TLS2_k127_4734691_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 5.695e-194 627.0
TLS2_k127_4734691_10 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000013 101.0
TLS2_k127_4734691_11 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000002503 88.0
TLS2_k127_4734691_12 deoxyhypusine monooxygenase activity - - - 0.0000000004939 72.0
TLS2_k127_4734691_2 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007079 379.0
TLS2_k127_4734691_3 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 365.0
TLS2_k127_4734691_4 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 370.0
TLS2_k127_4734691_5 Belongs to the ribF family K11753 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000004315 242.0
TLS2_k127_4734691_6 DHH family K06881 GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000001304 246.0
TLS2_k127_4734691_7 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000003414 219.0
TLS2_k127_4734691_8 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000009045 132.0
TLS2_k127_4734691_9 Transcriptional regulatory protein, C terminal K07658 - - 0.00000000000000000000004616 107.0
TLS2_k127_4746800_0 Phosphoribulokinase / Uridine kinase family K00867 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 376.0
TLS2_k127_4746800_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 364.0
TLS2_k127_4746800_2 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000003842 237.0
TLS2_k127_4746800_3 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000001959 214.0
TLS2_k127_4746800_4 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000005376 160.0
TLS2_k127_4746800_5 - - - - 0.0000000000000003535 91.0
TLS2_k127_4752846_0 [isocitrate dehydrogenase (NADP+)] phosphatase activity K00906 GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 477.0
TLS2_k127_4752846_1 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005853 348.0
TLS2_k127_4752846_10 - - - - 0.000000000000001624 80.0
TLS2_k127_4752846_2 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000628 340.0
TLS2_k127_4752846_3 ABC transporter, ATP-binding protein K06148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 329.0
TLS2_k127_4752846_4 (ABC) transporter K06147,K06148 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 330.0
TLS2_k127_4752846_5 3-methyladenine DNA glycosylase - - - 0.0000000000000000000000000000000000000000000000000000000000000008968 229.0
TLS2_k127_4752846_6 iron dependent repressor K03709 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000004319 205.0
TLS2_k127_4752846_7 FAD-dependent pyridine nucleotide-disulfide oxidoreductase - - - 0.0000000000000000000000000000000000000000009191 162.0
TLS2_k127_4752846_8 Iron-storage protein K02217 - 1.16.3.2 0.0000000000000000000000000000000000001355 147.0
TLS2_k127_4752846_9 acetylesterase activity - - - 0.00000000000000001548 85.0
TLS2_k127_4754942_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008107 412.0
TLS2_k127_4754942_1 PFAM penicillin-binding protein transpeptidase K05364 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 332.0
TLS2_k127_4754942_10 Forkhead associated domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.000000000000000004927 89.0
TLS2_k127_4754942_11 Forkhead associated domain K03466 - - 0.000000005198 66.0
TLS2_k127_4754942_2 Cell cycle protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008528 306.0
TLS2_k127_4754942_3 pfkB family carbohydrate kinase K00882 - 2.7.1.56 0.0000000000000000000000000000000000000000000000000000000000000000000008776 248.0
TLS2_k127_4754942_4 MFS_1 like family - - - 0.00000000000000000000000000000000000000000000000000000000000538 222.0
TLS2_k127_4754942_5 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K11991 - 3.5.4.1,3.5.4.33 0.0000000000000000000000000000000000000000000000007824 178.0
TLS2_k127_4754942_6 Survival protein SurE K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000001305 181.0
TLS2_k127_4754942_7 Tetratrico peptide repeat - - - 0.0000000000000000000000000000000000000000000004052 177.0
TLS2_k127_4754942_8 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000001169 154.0
TLS2_k127_4754942_9 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000001287 115.0
TLS2_k127_4768106_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007477 593.0
TLS2_k127_4768106_1 Phosphate starvation-inducible protein PhoH K06217 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 366.0
TLS2_k127_4768106_10 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000006447 169.0
TLS2_k127_4768106_11 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000003133 169.0
TLS2_k127_4768106_12 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000001104 158.0
TLS2_k127_4768106_13 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000001888 114.0
TLS2_k127_4768106_14 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000587 103.0
TLS2_k127_4768106_15 PFAM helix-turn-helix domain protein - - - 0.00000000000000003545 86.0
TLS2_k127_4768106_16 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000961 86.0
TLS2_k127_4768106_17 Protein of unknown function (DUF2568) - - - 0.00000000000002895 78.0
TLS2_k127_4768106_18 - - - - 0.0000004342 53.0
TLS2_k127_4768106_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 357.0
TLS2_k127_4768106_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002412 325.0
TLS2_k127_4768106_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003808 315.0
TLS2_k127_4768106_5 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009433 302.0
TLS2_k127_4768106_6 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K14215,K21273 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002843 274.0
TLS2_k127_4768106_7 SMART Metal-dependent phosphohydrolase, HD region K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001014 284.0
TLS2_k127_4768106_8 - - - - 0.0000000000000000000000000000000000000000000000000000000007602 209.0
TLS2_k127_4768106_9 Transporter associated domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000001441 183.0
TLS2_k127_4775614_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 4.778e-272 849.0
TLS2_k127_4775614_1 ABC transporter transmembrane region K02021,K06147,K16786,K16787 - - 6.749e-195 625.0
TLS2_k127_4775614_10 Thioredoxin K00384,K03671,K03672 - 1.8.1.8,1.8.1.9 0.0000000000000000000000000000000000000000000000001227 179.0
TLS2_k127_4775614_11 Acetyltransferase (GNAT) domain K03829 - - 0.00000000000000000000000000000000000000000000001067 175.0
TLS2_k127_4775614_12 Belongs to the UPF0301 (AlgH) family K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000004458 172.0
TLS2_k127_4775614_13 YbaK prolyl-tRNA synthetase associated region - - - 0.00000000000000000000000000000000000000000001429 166.0
TLS2_k127_4775614_14 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.000000000000000000000000000000000000000001344 165.0
TLS2_k127_4775614_15 DinB superfamily - - - 0.000000000000000000000000000000000001542 148.0
TLS2_k127_4775614_16 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000007238 144.0
TLS2_k127_4775614_17 - - - - 0.00000000000000000000000000581 125.0
TLS2_k127_4775614_18 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000005598 108.0
TLS2_k127_4775614_19 Sporulation and spore germination - - - 0.0000000000000000007222 100.0
TLS2_k127_4775614_2 ABC transporter transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 551.0
TLS2_k127_4775614_20 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.000000000000000003244 98.0
TLS2_k127_4775614_21 PFAM Pentapeptide repeats (8 copies) - - - 0.000000000000001034 87.0
TLS2_k127_4775614_22 Single-strand binding protein family K03111 - - 0.0000000135 62.0
TLS2_k127_4775614_3 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 546.0
TLS2_k127_4775614_4 Dehydrogenase K00004,K00060,K08322 GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0030246,GO:0042221,GO:0044238,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701 1.1.1.103,1.1.1.303,1.1.1.380,1.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004096 463.0
TLS2_k127_4775614_5 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II K01835,K01840 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 470.0
TLS2_k127_4775614_6 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007554 422.0
TLS2_k127_4775614_7 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002994 283.0
TLS2_k127_4775614_8 Monooxygenase K14733 - 1.14.13.107 0.000000000000000000000000000000000000000000000000000000000000000000000000009978 264.0
TLS2_k127_4775614_9 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003055 235.0
TLS2_k127_4776393_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 5.284e-290 911.0
TLS2_k127_4776393_1 PFAM carbohydrate kinase K00854 - 2.7.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007998 611.0
TLS2_k127_4776393_10 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001366 254.0
TLS2_k127_4776393_11 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000004004 258.0
TLS2_k127_4776393_12 Periplasmic binding protein LacI transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000002804 239.0
TLS2_k127_4776393_13 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000002965 194.0
TLS2_k127_4776393_14 Domain of unknown function (DUF5060) - - - 0.0000000000000000000000000000000000000000000000004063 196.0
TLS2_k127_4776393_15 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000001446 165.0
TLS2_k127_4776393_16 Helix-hairpin-helix motif K02237 - - 0.000000000000000000000000000000002646 137.0
TLS2_k127_4776393_17 Domain of unknown function (DUF4380) - - - 0.000000000000000000000000000000003807 140.0
TLS2_k127_4776393_18 AzlC protein - - - 0.00000000000000000000000000000002233 137.0
TLS2_k127_4776393_19 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000006047 102.0
TLS2_k127_4776393_2 Aldo/keto reductase family K19265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 495.0
TLS2_k127_4776393_20 Shikimate kinase K00891 - 2.7.1.71 0.0000000000000000005756 94.0
TLS2_k127_4776393_21 Acetyltransferase (GNAT) family - - - 0.00000000000000000192 90.0
TLS2_k127_4776393_22 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.0000000003583 67.0
TLS2_k127_4776393_23 - - - - 0.00007303 52.0
TLS2_k127_4776393_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 380.0
TLS2_k127_4776393_4 PFAM Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 325.0
TLS2_k127_4776393_5 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 304.0
TLS2_k127_4776393_6 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009535 296.0
TLS2_k127_4776393_7 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004784 274.0
TLS2_k127_4776393_8 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01190 - 3.2.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000009752 276.0
TLS2_k127_4776393_9 Belongs to the xylose isomerase family K01805 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000002205 263.0
TLS2_k127_4779436_0 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000135 205.0
TLS2_k127_4779436_1 L-asparaginase II - - - 0.0000000000000000000000000000000000000000000000000006626 197.0
TLS2_k127_4779436_2 heme binding K06401,K21472 - - 0.0000000000000000000000000000000000007913 153.0
TLS2_k127_4779436_3 - - - - 0.0000000000000000000000001716 112.0
TLS2_k127_4779436_4 CrcB-like protein, Camphor Resistance (CrcB) K06199 - - 0.00000000000000000000008382 102.0
TLS2_k127_4779436_5 PFAM Molybdopterin guanine dinucleotide synthesis protein B K06947 - - 0.000000000000006323 85.0
TLS2_k127_4779436_6 Mo-molybdopterin cofactor metabolic process K03636,K21142 - 2.8.1.12 0.00000000000001001 85.0
TLS2_k127_4779436_7 Putative bacterial sensory transduction regulator - - - 0.00000000001915 74.0
TLS2_k127_4779436_8 peptidase inhibitor activity - - - 0.000000000385 70.0
TLS2_k127_4794887_0 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009299 544.0
TLS2_k127_4794887_1 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006135 522.0
TLS2_k127_4794887_2 CoA binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007036 512.0
TLS2_k127_4794887_3 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005442 392.0
TLS2_k127_4794887_4 COG1177 ABC-type spermidine putrescine transport system, permease component II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 333.0
TLS2_k127_4794887_5 Putrescine transport system permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 319.0
TLS2_k127_4794887_6 Bacterial extracellular solute-binding protein K11069 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 317.0
TLS2_k127_4794887_7 Ring hydroxylating alpha subunit (catalytic domain) K00479 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000404 247.0
TLS2_k127_4794887_8 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000005319 226.0
TLS2_k127_4794887_9 BetI-type transcriptional repressor, C-terminal - - - 0.000000000000000000000000000000209 133.0
TLS2_k127_4798016_0 Belongs to the aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 518.0
TLS2_k127_4798016_1 Protein of unknown function (DUF2867) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 494.0
TLS2_k127_4798016_10 Belongs to the long-chain O-acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 351.0
TLS2_k127_4798016_11 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 307.0
TLS2_k127_4798016_12 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001618 285.0
TLS2_k127_4798016_13 Molybdenum cofactor synthesis domain protein K00963,K03750 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1,2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000002001 282.0
TLS2_k127_4798016_14 ATPase (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001751 270.0
TLS2_k127_4798016_15 Binding-protein-dependent transport system inner membrane component K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001514 272.0
TLS2_k127_4798016_16 acetyltransferase K18815 - 2.3.1.82 0.00000000000000000000000000000000000000000000000000000000000000000000004495 253.0
TLS2_k127_4798016_17 Belongs to the DapB family K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000003363 242.0
TLS2_k127_4798016_18 Bacterial extracellular solute-binding protein K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000002408 246.0
TLS2_k127_4798016_19 protein conserved in bacteria K09966 - - 0.000000000000000000000000000000000000000000000000000000000000007019 218.0
TLS2_k127_4798016_2 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 497.0
TLS2_k127_4798016_20 - - - - 0.000000000000000000000000000000000000000000000000000000000002023 219.0
TLS2_k127_4798016_21 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000003465 215.0
TLS2_k127_4798016_22 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000151 181.0
TLS2_k127_4798016_23 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000003343 176.0
TLS2_k127_4798016_24 Utp--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000443 177.0
TLS2_k127_4798016_25 PFAM Translin K07477 - - 0.0000000000000000000000000000000000000000008362 164.0
TLS2_k127_4798016_26 Domain of unknown function (DUF4126) - - - 0.0000000000000000000000000000000000000001725 165.0
TLS2_k127_4798016_27 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 0.000000000000000000000000000000000005176 144.0
TLS2_k127_4798016_28 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000004882 141.0
TLS2_k127_4798016_29 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine - - - 0.000000000000000000000000007638 115.0
TLS2_k127_4798016_3 Major Facilitator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004098 416.0
TLS2_k127_4798016_30 Pfam:Pyridox_oxidase - - - 0.00000000000000000000009907 104.0
TLS2_k127_4798016_31 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase - - - 0.000000000000000000001734 105.0
TLS2_k127_4798016_32 Regulatory protein, FmdB family - - - 0.000000000000000002192 91.0
TLS2_k127_4798016_33 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0005997 43.0
TLS2_k127_4798016_4 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 407.0
TLS2_k127_4798016_5 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 410.0
TLS2_k127_4798016_6 Belongs to the TPP enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 416.0
TLS2_k127_4798016_7 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 375.0
TLS2_k127_4798016_8 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 365.0
TLS2_k127_4798016_9 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000968 344.0
TLS2_k127_4800333_0 saccharopine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 318.0
TLS2_k127_4800333_1 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 312.0
TLS2_k127_4800333_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000001007 150.0
TLS2_k127_4800333_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.000000000000000000000000000000371 125.0
TLS2_k127_4800333_4 transcriptional - - - 0.00000000000000000000000000004841 118.0
TLS2_k127_4800333_5 Domain of unknown function (DUF1330) - - - 0.000000000000000000008151 95.0
TLS2_k127_4800333_6 protein conserved in bacteria - - - 0.000000000000000001324 95.0
TLS2_k127_4800333_7 Domain of unknown function (DUF222) - - - 0.000000000000001849 85.0
TLS2_k127_4800333_8 endonuclease activity - - - 0.00000003676 63.0
TLS2_k127_4800333_9 Belongs to the peptidase S16 family K07177 - - 0.0000003578 62.0
TLS2_k127_4800653_0 Insulinase (Peptidase family M16) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 403.0
TLS2_k127_4800653_1 cytokinin biosynthetic process K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 317.0
TLS2_k127_4800653_2 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000006323 236.0
TLS2_k127_4800653_3 BtpA family K06971 - - 0.000000000000000000000000000000000000000000000000000000002081 212.0
TLS2_k127_4800653_4 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.0000000000000000000000000000000000000000002811 167.0
TLS2_k127_4800653_6 ATPase associated with various cellular activities, AAA_5 K04748 - - 0.0000001141 63.0
TLS2_k127_4800653_7 metal-dependent phosphohydrolase HD region - - - 0.000002935 51.0
TLS2_k127_4822139_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 - 2.4.1.321 0.0 1161.0
TLS2_k127_4837073_0 Sulfatase - - - 0.0 1329.0
TLS2_k127_4837073_1 transferase activity, transferring glycosyl groups K19003,K20327 - 2.4.1.336 6.3e-235 746.0
TLS2_k127_4837073_10 LURP-one-related - - - 0.0000000000000000000000000000000000000000000000000000000000000001877 225.0
TLS2_k127_4837073_11 - - - - 0.00000000000000000000000000000000000000000000001003 176.0
TLS2_k127_4837073_12 Putative peptidoglycan binding domain - - - 0.00000000000000000000000000000000000000000000001528 188.0
TLS2_k127_4837073_13 involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - - 0.000000000000000000000000000000000000000000000257 181.0
TLS2_k127_4837073_14 - - - - 0.000000000000000000000000000000000000124 145.0
TLS2_k127_4837073_15 Phospholipase_D-nuclease N-terminal - - - 0.0000000000000000000000000000000000002728 145.0
TLS2_k127_4837073_16 - - - - 0.00000000000000000000000000005706 132.0
TLS2_k127_4837073_17 Short C-terminal domain - - - 0.00000000000000000000000007695 109.0
TLS2_k127_4837073_18 Endoribonuclease L-PSP - - - 0.0000000000000000000000008555 108.0
TLS2_k127_4837073_19 Putative adhesin - - - 0.00000000000000000001377 101.0
TLS2_k127_4837073_2 Sulfatase-modifying factor enzyme 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 438.0
TLS2_k127_4837073_20 COG2335, Secreted and surface protein containing fasciclin-like repeats - - - 0.00000000000000000008702 103.0
TLS2_k127_4837073_21 Sodium Bile acid symporter family K03453 - - 0.000000000000002056 87.0
TLS2_k127_4837073_22 - - - - 0.000000000004342 71.0
TLS2_k127_4837073_23 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000001654 68.0
TLS2_k127_4837073_24 RibD C-terminal domain - - - 0.00000000005611 63.0
TLS2_k127_4837073_3 helix_turn_helix, Lux Regulon K03556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 432.0
TLS2_k127_4837073_4 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 398.0
TLS2_k127_4837073_5 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005888 339.0
TLS2_k127_4837073_6 1-deoxy-D-xylulose-5-phosphate synthase K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003994 280.0
TLS2_k127_4837073_7 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001472 286.0
TLS2_k127_4837073_8 Bacterial sugar transferase K13012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006485 265.0
TLS2_k127_4837073_9 zinc transporter K07238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002324 250.0
TLS2_k127_4869385_0 Binding-protein-dependent transport system inner membrane component K02029 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 346.0
TLS2_k127_4869385_1 ABC transporter K02028,K09972 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 328.0
TLS2_k127_4869385_2 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000953 249.0
TLS2_k127_4869385_3 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001343 251.0
TLS2_k127_4869385_4 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000000000000000000000000000000004069 199.0
TLS2_k127_4869385_5 Inner membrane component domain - - - 0.000000000000000000000000000000000000009105 149.0
TLS2_k127_4869385_6 Bacterial transcriptional activator domain - - - 0.000000000000000001653 93.0
TLS2_k127_4869385_7 Sel1-like repeats. K14026 - - 0.00004165 46.0
TLS2_k127_4869786_0 Aminopeptidase K01256,K08776 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 595.0
TLS2_k127_4869786_1 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 545.0
TLS2_k127_4869786_10 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000004449 60.0
TLS2_k127_4869786_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009995 402.0
TLS2_k127_4869786_3 Phosphoserine phosphatase K01079 GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007499 371.0
TLS2_k127_4869786_4 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001216 269.0
TLS2_k127_4869786_5 polyphosphate glucokinase K00845,K00886 - 2.7.1.2,2.7.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000438 250.0
TLS2_k127_4869786_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000002936 204.0
TLS2_k127_4869786_7 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000007408 168.0
TLS2_k127_4869786_8 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000001567 163.0
TLS2_k127_4869786_9 Malic enzyme, NAD binding domain K00029 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.40 0.0000000000858 63.0
TLS2_k127_4870718_0 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 397.0
TLS2_k127_4870718_1 Elongator protein 3 MiaB NifB K11779 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000007178 274.0
TLS2_k127_4870718_10 Universal stress protein - - - 0.00001511 54.0
TLS2_k127_4870718_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001139 247.0
TLS2_k127_4870718_3 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000001983 235.0
TLS2_k127_4870718_4 Histidine kinase K07682 GO:0000166,GO:0000287,GO:0001666,GO:0003032,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009593,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0019825,GO:0019826,GO:0020037,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042165,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0051606,GO:0051775,GO:0051776,GO:0070025,GO:0070026,GO:0070482,GO:0070483,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000985 212.0
TLS2_k127_4870718_5 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000000000000000000000262 167.0
TLS2_k127_4870718_6 PFAM flavin reductase domain protein FMN-binding - - - 0.0000000000000000000007678 101.0
TLS2_k127_4870718_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000003389 93.0
TLS2_k127_4870718_8 - - - - 0.00000000000004728 78.0
TLS2_k127_4870718_9 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000002063 67.0
TLS2_k127_4875658_0 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 322.0
TLS2_k127_4875658_1 RNA pseudouridylate synthase K06178,K06183 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000075 252.0
TLS2_k127_4875658_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000002786 252.0
TLS2_k127_4875658_3 Tyrosine recombinase XerD K04763 GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000000000000000000000023 243.0
TLS2_k127_4875658_4 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000002892 164.0
TLS2_k127_4875658_5 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000001833 157.0
TLS2_k127_4875658_6 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000006352 76.0
TLS2_k127_4875658_7 mRNA catabolic process - - - 0.0001195 52.0
TLS2_k127_4904300_1 EamA-like transporter family K11939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000823 319.0
TLS2_k127_4904300_2 CGNR zinc finger - - - 0.00000000000000000000000000001981 124.0
TLS2_k127_4904300_3 Serine aminopeptidase, S33 - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000002365 59.0
TLS2_k127_4904300_4 - - - - 0.0000000789 55.0
TLS2_k127_4909883_0 Transcriptional regulator, LuxR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006911 466.0
TLS2_k127_4909883_1 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000006188 231.0
TLS2_k127_4909883_2 GCN5 family acetyltransferase - - - 0.000000000000000000000000000000000000000000000000001913 184.0
TLS2_k127_4909883_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000002588 145.0
TLS2_k127_4909883_4 SnoaL-like polyketide cyclase - - - 0.00000000000000001758 88.0
TLS2_k127_4927854_0 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 524.0
TLS2_k127_4927854_1 membrane protein terC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 399.0
TLS2_k127_4927854_10 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000001639 204.0
TLS2_k127_4927854_11 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000004992 179.0
TLS2_k127_4927854_12 carboxymethylenebutenolidase activity - - - 0.00000000000000000000000000000000000000000223 163.0
TLS2_k127_4927854_13 ribonuclease BN K07058 - - 0.0000000000000000000000000009851 124.0
TLS2_k127_4927854_14 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000000000000000000000008711 116.0
TLS2_k127_4927854_15 - - - - 0.000000000000000000006657 99.0
TLS2_k127_4927854_16 Acetyltransferase (GNAT) domain - - - 0.0000000000000000004552 97.0
TLS2_k127_4927854_17 Universal stress protein - - - 0.000000000009063 74.0
TLS2_k127_4927854_18 ABC-2 family transporter protein K01992 - - 0.00000000002029 73.0
TLS2_k127_4927854_19 LysM domain K03642,K03791,K22278 - 3.5.1.104 0.000002698 59.0
TLS2_k127_4927854_2 ATP dependent DNA ligase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 338.0
TLS2_k127_4927854_3 DNA primase, small subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 336.0
TLS2_k127_4927854_4 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 301.0
TLS2_k127_4927854_5 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0006950,GO:0006979,GO:0008113,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019538,GO:0030091,GO:0033744,GO:0036456,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114,GO:0071704,GO:1901564 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000122 285.0
TLS2_k127_4927854_6 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001634 278.0
TLS2_k127_4927854_8 MOSC domain - - - 0.0000000000000000000000000000000000000000000000000000002713 197.0
TLS2_k127_4927854_9 PFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000007857 200.0
TLS2_k127_4933252_0 Transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 435.0
TLS2_k127_4933252_1 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000000000000000009281 204.0
TLS2_k127_4933252_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000001343 198.0
TLS2_k127_4933252_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000004492 179.0
TLS2_k127_4933252_4 Histidine kinase - - - 0.000000000000000000000000000000000000000004892 169.0
TLS2_k127_4933252_5 Histidine kinase - - - 0.0000000000000000000000000000000000000006662 163.0
TLS2_k127_4933252_6 Histidine kinase - - - 0.00000000000000000000000000000000000005116 159.0
TLS2_k127_4933252_7 Histidine kinase - - - 0.0000000000000000000000000000000000001165 156.0
TLS2_k127_4933252_8 response regulator, receiver K02483,K07667 - - 0.0000000000000000000000004971 105.0
TLS2_k127_4933252_9 Histidine kinase - - - 0.000000000000000004156 96.0
TLS2_k127_4946058_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 512.0
TLS2_k127_4946058_1 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004553 454.0
TLS2_k127_4946058_2 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 372.0
TLS2_k127_4946058_3 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004967 282.0
TLS2_k127_4946058_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002819 229.0
TLS2_k127_4946058_5 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000001783 163.0
TLS2_k127_4946058_6 transcriptional regulator - - - 0.000000000000000000000000000002198 133.0
TLS2_k127_4946058_7 - - - - 0.00000000003614 70.0
TLS2_k127_4979782_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1215.0
TLS2_k127_4979782_1 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 471.0
TLS2_k127_4979782_2 Phospholipase_D-nuclease N-terminal - - - 0.0000000000000000000000000000000000000009193 151.0
TLS2_k127_4979782_3 helix_turn_helix, Lux Regulon K03556 - - 0.000000000000000000000000000002511 132.0
TLS2_k127_4979782_4 Amidinotransferase K01478 - 3.5.3.6 0.00000000006931 63.0
TLS2_k127_4979782_5 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000008687 68.0
TLS2_k127_4983850_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006839 434.0
TLS2_k127_4983850_1 Kynurenine--oxoglutarate transaminase - GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 428.0
TLS2_k127_4983850_2 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009968 300.0
TLS2_k127_4983850_3 PFAM extracellular solute-binding protein, family 5 - - - 0.00000000000000000000000000000000000000000000000001966 201.0
TLS2_k127_4983850_4 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000006671 192.0
TLS2_k127_4983850_5 PFAM regulatory protein, MerR - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000156 170.0
TLS2_k127_4983850_6 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000004911 161.0
TLS2_k127_4983850_7 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 0.0000000000000000000000000001267 126.0
TLS2_k127_4983850_8 Signal peptide protein - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006110,GO:0006140,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010563,GO:0010675,GO:0010677,GO:0016020,GO:0016310,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0030312,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0036211,GO:0042325,GO:0042326,GO:0042802,GO:0043170,GO:0043412,GO:0043457,GO:0043467,GO:0043470,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045820,GO:0045912,GO:0045934,GO:0045936,GO:0045980,GO:0046777,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901564,GO:1903578,GO:1903579,GO:2001169,GO:2001170 - 0.0000000000000000000000000777 112.0
TLS2_k127_4983850_9 Phosphoribosyl transferase domain K00760,K15780 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8,6.3.4.19 0.00000000094 62.0
TLS2_k127_5002329_0 arylsulfatase activity K01130 - 3.1.6.1 0.0 1017.0
TLS2_k127_5002329_1 Membrane bound O-acyl transferase MBOAT family protein K03739,K19294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 370.0
TLS2_k127_5002329_10 Metallo-beta-lactamase superfamily - - - 0.00000000000001068 76.0
TLS2_k127_5002329_11 Acyltransferase family - - - 0.00000000000436 72.0
TLS2_k127_5002329_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002794 334.0
TLS2_k127_5002329_3 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000006726 198.0
TLS2_k127_5002329_4 Haem-binding domain - - - 0.0000000000000000000000000000000000000000000000006601 180.0
TLS2_k127_5002329_5 GyrI-like small molecule binding domain - - - 0.000000000000000000000000000000000000000000000003315 180.0
TLS2_k127_5002329_6 Sulfatase - - - 0.00000000000000000000000000000000000000000002255 173.0
TLS2_k127_5002329_7 Protein of unknown function (DUF459) K09795 - - 0.0000000000000000000000000000000000000001907 164.0
TLS2_k127_5002329_8 - - - - 0.00000000000000002405 87.0
TLS2_k127_5002329_9 Serine aminopeptidase, S33 - - - 0.0000000000000005241 79.0
TLS2_k127_5067167_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008078 586.0
TLS2_k127_5067167_1 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008699 500.0
TLS2_k127_5067167_10 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000007631 196.0
TLS2_k127_5067167_11 Acyltransferase - - - 0.00000000000000000000000000000000000000004403 158.0
TLS2_k127_5067167_12 Bax inhibitor 1 like - - - 0.000000000000000000000000001879 113.0
TLS2_k127_5067167_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000007601 109.0
TLS2_k127_5067167_14 PFAM Rhodanese domain protein - - - 0.0000000000000004296 83.0
TLS2_k127_5067167_15 - - - - 0.00000000001418 78.0
TLS2_k127_5067167_16 - - - - 0.000007085 55.0
TLS2_k127_5067167_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 465.0
TLS2_k127_5067167_3 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 428.0
TLS2_k127_5067167_4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 396.0
TLS2_k127_5067167_5 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 - 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 373.0
TLS2_k127_5067167_6 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 350.0
TLS2_k127_5067167_7 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 296.0
TLS2_k127_5067167_8 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000659 224.0
TLS2_k127_5067167_9 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000003818 218.0
TLS2_k127_5115101_0 Transcriptional regulator, LuxR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 421.0
TLS2_k127_5115101_1 Histidine kinase K07646 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003789 349.0
TLS2_k127_5115101_10 YCII-related domain - - - 0.000003373 51.0
TLS2_k127_5115101_11 Transposase (IS116 IS110 IS902 family) - - - 0.0002876 48.0
TLS2_k127_5115101_12 Bacterial regulatory proteins, tetR family - - - 0.0003381 48.0
TLS2_k127_5115101_2 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 332.0
TLS2_k127_5115101_3 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 343.0
TLS2_k127_5115101_4 COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07667 GO:0008150,GO:0040007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 314.0
TLS2_k127_5115101_5 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007808 241.0
TLS2_k127_5115101_6 Plasmid maintenance system killer K07334 - - 0.00000000000000000000000000000000000002681 144.0
TLS2_k127_5115101_7 Helix-turn-helix XRE-family like proteins K21498 - - 0.00000000000000000000000000000000006576 141.0
TLS2_k127_5115101_8 Histidine kinase - - - 0.00000000000000000000000000003266 131.0
TLS2_k127_5115101_9 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000002462 67.0
TLS2_k127_5151007_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 384.0
TLS2_k127_5151007_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 327.0
TLS2_k127_5151007_10 Universal stress protein - - - 0.000000000000001917 81.0
TLS2_k127_5151007_11 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000002699 63.0
TLS2_k127_5151007_12 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.00000508 54.0
TLS2_k127_5151007_14 DNA integration - - - 0.0006171 45.0
TLS2_k127_5151007_2 Domain of unknown function (DUF2437) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002083 281.0
TLS2_k127_5151007_3 Domain of unknown function (DUF427) - - - 0.000000000000000000000000000000000000000004625 156.0
TLS2_k127_5151007_4 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000009225 161.0
TLS2_k127_5151007_5 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000001096 136.0
TLS2_k127_5151007_6 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000001343 134.0
TLS2_k127_5151007_7 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.00000000000000001817 90.0
TLS2_k127_5151007_8 Belongs to the phosphoglycerate mutase family K02226,K22305 - 3.1.3.3,3.1.3.73 0.00000000000000003271 93.0
TLS2_k127_5151007_9 PFAM methyltransferase - - - 0.000000000000001396 85.0
TLS2_k127_5171039_0 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000001644 252.0
TLS2_k127_5171039_1 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000002035 263.0
TLS2_k127_5171039_2 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950,K13940 - 2.7.6.3,4.1.2.25 0.0000000000000000000000000000005972 134.0
TLS2_k127_5171039_3 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K00950,K13940 - 2.7.6.3,4.1.2.25 0.0000000000000000000000000000228 123.0
TLS2_k127_5171039_4 - - - - 0.0000000000000000000000004274 112.0
TLS2_k127_5171039_5 Methyltransferase - - - 0.00000000000126 78.0
TLS2_k127_5171039_6 protein encoded in hypervariable junctions of pilus gene clusters - - - 0.00000000003291 70.0
TLS2_k127_5212351_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 306.0
TLS2_k127_5212351_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.0000000000000000000000000000000000000000000000000000000000000000001394 256.0
TLS2_k127_5212351_2 ABC transporter substrate-binding protein K02030,K02424,K17073 - - 0.000000000000000000000000000000000000000000000000006918 187.0
TLS2_k127_5212351_3 alpha-ribazole phosphatase activity K02226,K15634 - 3.1.3.73,5.4.2.12 0.00000000000000000000000000000000000000000000001004 188.0
TLS2_k127_5212351_4 Haemolysin-III related K11068 - - 0.00000000000000000000000000000000000000105 156.0
TLS2_k127_5212351_5 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000001841 130.0
TLS2_k127_5212351_6 cation transport ATPase K01533,K01534,K12954,K17686 - 3.6.3.3,3.6.3.4,3.6.3.5,3.6.3.54 0.00000000000000000000000001763 109.0
TLS2_k127_5212351_7 - - - - 0.000000000000000002792 87.0
TLS2_k127_5301291_0 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01667,K01668 - 4.1.99.1,4.1.99.2 1.669e-199 634.0
TLS2_k127_5301291_1 helicase superfamily c-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 385.0
TLS2_k127_5301291_2 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000489 275.0
TLS2_k127_5301291_3 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000007793 183.0
TLS2_k127_5301291_4 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000001279 148.0
TLS2_k127_5301291_5 OsmC-like protein - - - 0.00000000000000000000000009327 113.0
TLS2_k127_5392445_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K15408 - 1.9.3.1 6.146e-212 685.0
TLS2_k127_5392445_1 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006479 403.0
TLS2_k127_5392445_10 Redoxin K03386 - 1.11.1.15 0.000672 51.0
TLS2_k127_5392445_2 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008459 269.0
TLS2_k127_5392445_3 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000007159 234.0
TLS2_k127_5392445_4 Cyclase dehydrase - - - 0.0000000000000000000000000000000000000000000000000000000000000279 217.0
TLS2_k127_5392445_5 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000001526 203.0
TLS2_k127_5392445_6 - - - - 0.0000000000000000000000000000000000000000009668 168.0
TLS2_k127_5392445_7 Cytochrome c oxidase caa3-type, assembly factor K02351 - - 0.000000000000000000000001302 116.0
TLS2_k127_5392445_8 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000009551 72.0
TLS2_k127_5392445_9 SnoaL-like domain - - - 0.00000008941 58.0
TLS2_k127_5626812_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003679 409.0
TLS2_k127_5626812_1 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 406.0
TLS2_k127_5626812_10 Glycosyltransferase, group 2 family protein - - - 0.00000000000000728 87.0
TLS2_k127_5626812_11 Uncharacterized conserved protein (DUF2304) K09153 - - 0.000000004888 68.0
TLS2_k127_5626812_12 Glycosyl transferase, family 2 K09809 - 2.7.8.12 0.00003749 48.0
TLS2_k127_5626812_13 - - - - 0.00009574 55.0
TLS2_k127_5626812_2 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 399.0
TLS2_k127_5626812_3 PFAM Glycosyl transferase family 2 K20444 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003369 387.0
TLS2_k127_5626812_4 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004376 357.0
TLS2_k127_5626812_5 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004295 314.0
TLS2_k127_5626812_6 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002407 240.0
TLS2_k127_5626812_7 Udp N-acetylglucosamine O-acyltransferase; Domain 2 K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000007652 220.0
TLS2_k127_5626812_8 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 1.1.1.133 0.000000000000000000000000000000000000000000000000000000003912 218.0
TLS2_k127_5626812_9 CoA-binding domain K19421 GO:0008150,GO:0043900,GO:0043902,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:1900190,GO:1900192 - 0.000000000000000002326 95.0
TLS2_k127_5633222_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 GO:0005575,GO:0005576,GO:0008150,GO:0040007 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008375 507.0
TLS2_k127_5633222_1 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 307.0
TLS2_k127_5633222_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000001163 274.0
TLS2_k127_5633222_3 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000002891 245.0
TLS2_k127_5633222_4 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000009231 222.0
TLS2_k127_5633222_5 riboflavin synthase, alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000005751 207.0
TLS2_k127_5633222_6 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000001137 173.0
TLS2_k127_5635881_0 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 497.0
TLS2_k127_5635881_1 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 422.0
TLS2_k127_5635881_2 DAHP synthetase I family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003328 357.0
TLS2_k127_5635881_3 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001329 270.0
TLS2_k127_5635881_4 Cro/C1-type HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000002925 171.0
TLS2_k127_5635881_5 NIPSNAP - - - 0.000000000000000000000000000000000001951 140.0
TLS2_k127_5635881_6 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000000000000000000001409 98.0
TLS2_k127_5635881_7 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000002554 91.0
TLS2_k127_5635881_8 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000004404 60.0
TLS2_k127_5635881_9 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020,K00042 - 1.1.1.31,1.1.1.60 0.0007745 42.0
TLS2_k127_5640662_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 3.6.3.14 1.843e-212 671.0
TLS2_k127_5640662_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006943 494.0
TLS2_k127_5640662_10 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0000225 54.0
TLS2_k127_5640662_11 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.00002911 49.0
TLS2_k127_5640662_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000002703 179.0
TLS2_k127_5640662_3 phosphatase activity K07025 - - 0.000000000000000000000000000000000000004087 154.0
TLS2_k127_5640662_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000000000000281 149.0
TLS2_k127_5640662_5 Belongs to the SUA5 family K07566 GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.87 0.0000000000000000000000000000000000004447 149.0
TLS2_k127_5640662_6 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000001136 128.0
TLS2_k127_5640662_7 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000001063 91.0
TLS2_k127_5640662_8 S-layer homology domain - - - 0.00000000000000332 87.0
TLS2_k127_5640662_9 - - - - 0.0000000002188 67.0
TLS2_k127_5652432_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.949e-264 835.0
TLS2_k127_5652432_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007423 464.0
TLS2_k127_5652432_10 flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000004547 151.0
TLS2_k127_5652432_11 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000001497 95.0
TLS2_k127_5652432_12 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000005477 87.0
TLS2_k127_5652432_13 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.000000000000171 84.0
TLS2_k127_5652432_14 - - - - 0.00000745 54.0
TLS2_k127_5652432_15 - - - - 0.00004603 54.0
TLS2_k127_5652432_2 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 433.0
TLS2_k127_5652432_3 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 402.0
TLS2_k127_5652432_4 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006848 381.0
TLS2_k127_5652432_5 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002812 256.0
TLS2_k127_5652432_6 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000003798 228.0
TLS2_k127_5652432_7 Cell envelope-related transcriptional attenuator domain - - - 0.0000000000000000000000000000000000000000000000000000000000001582 227.0
TLS2_k127_5652432_8 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000001756 214.0
TLS2_k127_5652432_9 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000003055 185.0
TLS2_k127_5660141_0 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006484 357.0
TLS2_k127_5660141_1 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 354.0
TLS2_k127_5660141_2 Patched family K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001474 308.0
TLS2_k127_5660141_3 May catalyze the transamination reaction in phenylalanine biosynthesis K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000001023 267.0
TLS2_k127_5660141_4 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000000002573 203.0
TLS2_k127_5660141_5 ABC transporter transmembrane region K02021,K06147,K16786,K16787 - - 0.000000000000000000000000000000000000000000000000001354 185.0
TLS2_k127_5660141_6 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000009185 152.0
TLS2_k127_5660141_7 Bacterial transcriptional repressor C-terminal - - - 0.00000000000000000000000001243 116.0
TLS2_k127_5660141_8 Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system K05997,K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016530,GO:0019538,GO:0022607,GO:0031163,GO:0034986,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:0140104,GO:1901564 - 0.000003098 58.0
TLS2_k127_5687496_0 Domain of unknown function (DUF4389) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 319.0
TLS2_k127_5687496_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001694 240.0
TLS2_k127_5687496_2 PFAM Abortive infection protein - - - 0.0000000000000005611 86.0
TLS2_k127_5687496_3 Serine aminopeptidase, S33 - - - 0.000000000369 67.0
TLS2_k127_5731942_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000999 605.0
TLS2_k127_5731942_1 helicase superfamily c-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 406.0
TLS2_k127_5731942_2 possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP catalytic activity ATP H(2)O undeterminated metal cation(in) ADP phosphate undeterminated metal cation(out) K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 301.0
TLS2_k127_5731942_3 PFAM Fatty acid desaturase, type 2 K03921 - 1.14.19.11,1.14.19.2,1.14.19.26 0.0000000000000000000000000000000000000000000000000000000000000000000000001747 257.0
TLS2_k127_5731942_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000003714 181.0
TLS2_k127_5731942_5 - - - - 0.000000000000000000000000000000000000000000003931 169.0
TLS2_k127_5731942_6 - K01992 - - 0.000000000000000000000002156 117.0
TLS2_k127_5731942_7 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.0000000000000000000008996 111.0
TLS2_k127_5731942_8 - - - - 0.00000000000002711 78.0
TLS2_k127_5742805_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 609.0
TLS2_k127_5742805_1 involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 333.0
TLS2_k127_5742805_10 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.0001546 46.0
TLS2_k127_5742805_2 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006364 308.0
TLS2_k127_5742805_3 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003649 287.0
TLS2_k127_5742805_4 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002866 254.0
TLS2_k127_5742805_5 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000002338 229.0
TLS2_k127_5742805_6 PFAM Methyltransferase type 12 - - - 0.0000000000000000000000000000000000000001517 158.0
TLS2_k127_5742805_8 cyclic nucleotide binding K01420,K10914 - - 0.00000002354 57.0
TLS2_k127_5742805_9 Short-chain dehydrogenase reductase SDR - - - 0.000002141 53.0
TLS2_k127_5768011_0 ABC transporter related K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007981 570.0
TLS2_k127_5768011_1 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 386.0
TLS2_k127_5768011_2 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000319 369.0
TLS2_k127_5768011_3 ABC transporter substrate-binding protein PnrA-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009696 324.0
TLS2_k127_5768011_4 queuosine salvage K09125 - - 0.00000000000000000000000000000000000001304 148.0
TLS2_k127_5768636_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000898 556.0
TLS2_k127_5768636_1 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008482 449.0
TLS2_k127_5768636_2 AP endonuclease family 2 C terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000549 438.0
TLS2_k127_5768636_3 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009159 429.0
TLS2_k127_5768636_4 Periplasmic binding protein domain K02058,K10439,K17213 GO:0003674,GO:0005215,GO:0005488,GO:0005534,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0015144,GO:0015145,GO:0015749,GO:0015757,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 318.0
TLS2_k127_5768636_5 ABC-2 type transporter K01992 - - 0.000000000000000000002144 95.0
TLS2_k127_5771782_0 DNA polymerase alpha chain like domain K02337 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 0.0 1114.0
TLS2_k127_5771782_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 8.449e-219 707.0
TLS2_k127_5771782_10 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000001742 217.0
TLS2_k127_5771782_11 Transcriptional regulatory protein, C terminal K07776 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000005809 210.0
TLS2_k127_5771782_12 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.00000000000000000000000000000000000000000000000000008313 190.0
TLS2_k127_5771782_13 Pfam Anion-transporting ATPase - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000009509 198.0
TLS2_k127_5771782_14 Cytochrome C biogenesis protein transmembrane region K06196,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000007298 186.0
TLS2_k127_5771782_15 protein encoded in hypervariable junctions of pilus gene clusters - - - 0.000000000000000000000000000000000000000000000002429 178.0
TLS2_k127_5771782_16 His Kinase A (phosphoacceptor) domain K07642 - 2.7.13.3 0.000000000000000000000000000000000000000000005645 182.0
TLS2_k127_5771782_17 PFAM Anion-transporting ATPase - - - 0.0000000000000000000000000000000000000000003917 171.0
TLS2_k127_5771782_18 Aminomethyltransferase folate-binding domain K06980 - - 0.000000000000000000000000001016 123.0
TLS2_k127_5771782_19 - - - - 0.000000000002954 72.0
TLS2_k127_5771782_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009125,GO:0009129,GO:0009130,GO:0009131,GO:0009157,GO:0009159,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009178,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0032259,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042083,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046073,GO:0046078,GO:0046079,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000947 454.0
TLS2_k127_5771782_20 Major facilitator superfamily - - - 0.0000000003077 72.0
TLS2_k127_5771782_3 Ribosomal protein S1 K02945 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 462.0
TLS2_k127_5771782_4 Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008861 433.0
TLS2_k127_5771782_5 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 414.0
TLS2_k127_5771782_6 transport, permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008515 338.0
TLS2_k127_5771782_7 COGs COG0534 Na -driven multidrug efflux pump K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008966 308.0
TLS2_k127_5771782_8 Putative adhesin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001004 252.0
TLS2_k127_5771782_9 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000009626 242.0
TLS2_k127_5793349_0 Alkyl sulfatase dimerisation - - - 1.211e-318 989.0
TLS2_k127_5793349_1 Fic/DOC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 541.0
TLS2_k127_5793349_10 - - - - 0.000000000000000000000000000000000000000000000000000000000001555 217.0
TLS2_k127_5793349_11 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000105 231.0
TLS2_k127_5793349_12 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000000000000000000000000003106 211.0
TLS2_k127_5793349_13 Protein of unknown function (DUF2938) - - - 0.0000000000000000000000000000000000000000000000000000004382 201.0
TLS2_k127_5793349_14 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000000000000002505 198.0
TLS2_k127_5793349_15 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000001379 189.0
TLS2_k127_5793349_16 F420H(2)-dependent quinone reductase - - - 0.0000000000000000000000000000000000000000000000003317 185.0
TLS2_k127_5793349_17 Sigma-70 region 2 - - - 0.00000000000000000000000000000000000000000000021 174.0
TLS2_k127_5793349_18 Histidine kinase - - - 0.00000000000000000000000000000000000000000007882 175.0
TLS2_k127_5793349_19 - - - - 0.000000000000000000000000000000000001041 144.0
TLS2_k127_5793349_2 bifunctional deaminase-reductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 330.0
TLS2_k127_5793349_20 Beta-lactamase - - - 0.00000000000000000000000000005006 125.0
TLS2_k127_5793349_21 MarR family - - - 0.00000000000000000000000002659 114.0
TLS2_k127_5793349_22 Domain of unknown function (DU1801) - - - 0.000000000000000000001167 95.0
TLS2_k127_5793349_23 PFAM Abortive infection protein - - - 0.000000000000000007764 94.0
TLS2_k127_5793349_24 Domain of unknown function (DU1801) - - - 0.00000000000000001635 85.0
TLS2_k127_5793349_25 2TM domain - - - 0.000000000000001099 81.0
TLS2_k127_5793349_26 - - - - 0.0000001456 57.0
TLS2_k127_5793349_27 Alpha beta hydrolase - - - 0.000002436 52.0
TLS2_k127_5793349_28 - - - - 0.00005135 49.0
TLS2_k127_5793349_29 gnat family - - - 0.000228 46.0
TLS2_k127_5793349_3 Domain of unknown function (DUF4389) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 313.0
TLS2_k127_5793349_4 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 302.0
TLS2_k127_5793349_5 Belongs to the dihydrofolate reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 291.0
TLS2_k127_5793349_6 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000237 282.0
TLS2_k127_5793349_7 Domain of unknown function (DUF4386) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005389 269.0
TLS2_k127_5793349_8 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004611 270.0
TLS2_k127_5793349_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000002113 246.0
TLS2_k127_5795209_0 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001511 277.0
TLS2_k127_5795209_1 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000001998 250.0
TLS2_k127_5795209_2 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000001113 171.0
TLS2_k127_5795209_3 acetylesterase activity - - - 0.000000000000000000000000000000000000000000003672 186.0
TLS2_k127_5795209_4 AI-2E family transporter - - - 0.000000000000000000000000000000000000003519 162.0
TLS2_k127_5795209_5 - - - - 0.00009597 53.0
TLS2_k127_5807067_0 penicillin amidase K01434 - 3.5.1.11 2.054e-239 770.0
TLS2_k127_5807067_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02827 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.10.3.12,1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009614 597.0
TLS2_k127_5807067_10 Ferredoxin K02230 - 6.6.1.2 0.0000000000000000000000000000465 121.0
TLS2_k127_5807067_11 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000003061 126.0
TLS2_k127_5807067_12 cell redox homeostasis K02199 - - 0.00000000000000000000000001483 126.0
TLS2_k127_5807067_13 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - - 0.0000000000004617 76.0
TLS2_k127_5807067_14 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.000000000006382 71.0
TLS2_k127_5807067_2 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 351.0
TLS2_k127_5807067_3 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 320.0
TLS2_k127_5807067_4 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 317.0
TLS2_k127_5807067_5 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 310.0
TLS2_k127_5807067_6 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002455 262.0
TLS2_k127_5807067_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002347 261.0
TLS2_k127_5807067_8 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000969 205.0
TLS2_k127_5807067_9 Cytochrome c oxidase subunit III K02276,K02299 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 0.0000000000000000000000000000000000000000000000000000009928 199.0
TLS2_k127_5864772_1 PFAM ABC transporter related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004811 288.0
TLS2_k127_5864772_2 Uncharacterised protein family UPF0047 - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000005008 183.0
TLS2_k127_5864772_3 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000005249 137.0
TLS2_k127_5943612_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006121 573.0
TLS2_k127_5943612_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003222 530.0
TLS2_k127_5943612_2 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000534 383.0
TLS2_k127_5943612_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000001805 180.0
TLS2_k127_5943612_4 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000651 149.0
TLS2_k127_5943612_5 Winged helix DNA-binding domain K09927 - - 0.0000000000000000000000000000000007746 132.0
TLS2_k127_5943612_6 glutamine synthetase K01915 GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 0.000000002441 58.0
TLS2_k127_599188_0 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 323.0
TLS2_k127_599188_1 Sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001605 280.0
TLS2_k127_599188_2 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001265 273.0
TLS2_k127_599188_3 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001096 270.0
TLS2_k127_599188_4 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004214 269.0
TLS2_k127_599188_5 Glycosyl transferase WecB/TagA/CpsF family K05946 - 2.4.1.187 0.00000000000000000000000000000000000000000000000000000000002567 216.0
TLS2_k127_599188_6 - - - - 0.0000000000000000000000000000000000000000000000000000000003375 213.0
TLS2_k127_599188_7 Macrocin-O-methyltransferase (TylF) K05303 - - 0.00000000000000000000000000000000000000000000000001884 189.0
TLS2_k127_599188_8 peptidoglycan biosynthetic process K03980 - - 0.0000000000000000001445 102.0
TLS2_k127_599188_9 O-Antigen ligase - - - 0.000000001094 72.0
TLS2_k127_6003475_0 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003899 350.0
TLS2_k127_6003475_1 PFAM glycosyl transferase, family 51 K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001501 308.0
TLS2_k127_6003475_2 polysaccharide biosynthetic process K01992 GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009987,GO:0044764,GO:0046812,GO:0051704 - 0.000001274 61.0
TLS2_k127_6022174_0 belongs to the aldehyde dehydrogenase family K00130,K00151 - 1.2.1.60,1.2.1.8 5.267e-223 711.0
TLS2_k127_6022174_1 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 383.0
TLS2_k127_6022174_10 Diacylglycerol kinase catalytic domain (presumed) - - - 0.000000000000000006863 94.0
TLS2_k127_6022174_11 HNH endonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000005034 84.0
TLS2_k127_6022174_2 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005076 391.0
TLS2_k127_6022174_3 Acetoacetate decarboxylase (ADC) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 335.0
TLS2_k127_6022174_4 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004034 314.0
TLS2_k127_6022174_5 Alcohol dehydrogenase GroES-like domain K00001,K00008 - 1.1.1.1,1.1.1.14 0.00000000000000000000000000000000000000000000000000005959 201.0
TLS2_k127_6022174_6 mechanosensitive ion channel K22044 - - 0.000000000000000000000000000000000000000000000000002329 198.0
TLS2_k127_6022174_7 50S ribosome-binding GTPase - - - 0.000000000000000000000000000000000000000000000599 181.0
TLS2_k127_6022174_8 Dynamin family - - - 0.000000000000000000000000000000000008846 153.0
TLS2_k127_6022174_9 transcriptional regulator - - - 0.000000000000000000000000000000000009912 142.0
TLS2_k127_6024717_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003464 527.0
TLS2_k127_6024717_1 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007786 487.0
TLS2_k127_6024717_2 Fe-S oxidoreductase K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000002122 249.0
TLS2_k127_6024717_3 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000002168 156.0
TLS2_k127_6024717_4 FAD binding domain K11472 - - 0.0000000000000000000000000000000000000003446 164.0
TLS2_k127_6024717_5 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000005096 107.0
TLS2_k127_6091214_0 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002352 278.0
TLS2_k127_6091214_1 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000001018 113.0
TLS2_k127_6091214_2 - - - - 0.000000000000000000003064 104.0
TLS2_k127_6091214_3 SpoIID LytB domain protein - - - 0.0000000000002885 81.0
TLS2_k127_6091214_4 Belongs to the glycosyl hydrolase family 6 - - - 0.00000004165 66.0
TLS2_k127_6091214_6 S-layer homology domain - - - 0.000159 53.0
TLS2_k127_6149756_0 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000001333 218.0
TLS2_k127_6149756_1 Transposase IS116 IS110 IS902 family protein - - - 0.00000000000000000000000000000000000000000000000000009996 193.0
TLS2_k127_6149756_2 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000004659 116.0
TLS2_k127_6149756_3 Transposase - - - 0.000000000000000000000002202 111.0
TLS2_k127_6195096_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 1.338e-308 965.0
TLS2_k127_6195096_1 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006657 394.0
TLS2_k127_6195096_2 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009947 264.0
TLS2_k127_6195096_3 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000000000000000000000000000003019 180.0
TLS2_k127_6195096_4 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000000000000001093 141.0
TLS2_k127_6195096_5 Protein of unknown function (DUF2587) - GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 - 0.0000000000000000000000000000000008321 134.0
TLS2_k127_6195096_6 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.0000000000000000000000000002706 116.0
TLS2_k127_6195096_7 TadE-like protein - - - 0.000000000000000005049 91.0
TLS2_k127_6195096_8 PFAM TadE family protein - - - 0.000002621 57.0
TLS2_k127_6195096_9 PFAM TadE family protein - - - 0.00013 51.0
TLS2_k127_6217642_0 ABC-type dipeptide transport system periplasmic component K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006046 570.0
TLS2_k127_6217642_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007703 472.0
TLS2_k127_6217642_10 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002588 272.0
TLS2_k127_6217642_11 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000789 262.0
TLS2_k127_6217642_12 Cobalt ABC transporter K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003081 245.0
TLS2_k127_6217642_13 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000769 224.0
TLS2_k127_6217642_14 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.0000000000000000000000000000000000000000000000000000000000002534 226.0
TLS2_k127_6217642_15 PFAM sugar transferase - - - 0.00000000000000000000000000000000000000004789 168.0
TLS2_k127_6217642_16 belongs to the Fur family K03711 - - 0.000000000000000000005924 100.0
TLS2_k127_6217642_17 Belongs to the Fur family K03711,K09825 - - 0.0000000000000000003518 93.0
TLS2_k127_6217642_2 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005846 451.0
TLS2_k127_6217642_3 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 417.0
TLS2_k127_6217642_4 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005105 376.0
TLS2_k127_6217642_5 Peptidase, M20 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 340.0
TLS2_k127_6217642_6 Part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 322.0
TLS2_k127_6217642_7 cystathionine beta-lyase activity K14155 - 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007024 320.0
TLS2_k127_6217642_8 Peptidase family M20/M25/M40 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 312.0
TLS2_k127_6217642_9 ABC 3 transport family K02075,K09819 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004068 281.0
TLS2_k127_6263676_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005863 450.0
TLS2_k127_6263676_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 355.0
TLS2_k127_6263676_2 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000003115 219.0
TLS2_k127_6263676_3 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000003248 186.0
TLS2_k127_6263676_4 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - 0.00000000000000000000000001229 117.0
TLS2_k127_6263676_5 Cell division protein FtsQ K03589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - 0.00000000003794 73.0
TLS2_k127_6264402_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000003867 246.0
TLS2_k127_6264402_1 GtrA-like protein - - - 0.0000000000000000001511 97.0
TLS2_k127_6264402_2 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA K09772 - - 0.0000000000000004151 85.0
TLS2_k127_6264402_3 YGGT family K02221 - - 0.00000128 54.0
TLS2_k127_6264402_4 DivIVA protein - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944 - 0.000001591 59.0
TLS2_k127_6286293_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.041e-282 880.0
TLS2_k127_6286293_1 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000001771 134.0
TLS2_k127_6286293_2 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.000000000000000000000000003062 123.0
TLS2_k127_6286293_3 Histidine kinase - - - 0.0000000000000000000001374 112.0
TLS2_k127_6286293_4 Flp Fap pilin component K02651 - - 0.0005817 44.0
TLS2_k127_6294466_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 471.0
TLS2_k127_6294466_1 Malate/L-lactate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 293.0
TLS2_k127_6294466_2 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004862 275.0
TLS2_k127_6294466_3 Dehydrogenase K00101 - 1.1.2.3 0.000000000000000000000000000000000000000000000000000000000003188 223.0
TLS2_k127_6294466_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000004289 170.0
TLS2_k127_6294466_5 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000005086 158.0
TLS2_k127_6294466_6 Oxidoreductase family, C-terminal alpha/beta domain K19181 - 1.1.1.292 0.00000000000000000000000000000000000003686 156.0
TLS2_k127_6294466_7 Amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000001659 124.0
TLS2_k127_6294466_8 Mannose-6-phosphate isomerase - - - 0.0000000000000000000000005388 108.0
TLS2_k127_6313555_0 Periplasmic binding protein K01999 - - 1.675e-213 675.0
TLS2_k127_6313555_1 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000436 594.0
TLS2_k127_6313555_10 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002775 300.0
TLS2_k127_6313555_11 ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007631 285.0
TLS2_k127_6313555_12 Enoyl-(Acyl carrier protein) reductase K00065 - 1.1.1.127 0.0000000000000000000000000000000000000000000000000000000000000000000002836 246.0
TLS2_k127_6313555_13 Truncated hemoglobins K06886 - - 0.00000000000000000000000000000000000000000000000000000000004732 208.0
TLS2_k127_6313555_14 Cupin - - - 0.0000000000000000000000000000000000000000000000000000001496 199.0
TLS2_k127_6313555_15 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000001909 190.0
TLS2_k127_6313555_16 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000007293 152.0
TLS2_k127_6313555_17 Fic/DOC family - - - 0.000000000000000000000000000000000000002933 153.0
TLS2_k127_6313555_18 - - - - 0.00000000000000000000000000000000058 136.0
TLS2_k127_6313555_19 Transcriptional regulator - - - 0.000000000000000000000000000000004263 140.0
TLS2_k127_6313555_2 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 588.0
TLS2_k127_6313555_20 Helix-turn-helix domain K07729 - - 0.00000000000000000000000000000007783 128.0
TLS2_k127_6313555_21 PFAM AP endonuclease family 2 C terminus - - - 0.0000000000000000000000000000113 133.0
TLS2_k127_6313555_22 Domain of unknown function (DUF4440) - - - 0.000000000000000000002437 97.0
TLS2_k127_6313555_23 - - - - 0.0000000000000001033 88.0
TLS2_k127_6313555_3 Uncharacterised protein family (UPF0261) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 501.0
TLS2_k127_6313555_4 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 472.0
TLS2_k127_6313555_5 Phosphoenolpyruvate hydrolase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 463.0
TLS2_k127_6313555_6 Uncharacterised protein family (UPF0261) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 425.0
TLS2_k127_6313555_7 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008038 398.0
TLS2_k127_6313555_8 Xylose isomerase-like TIM barrel K18910 GO:0003674,GO:0003824,GO:0005488,GO:0016853,GO:0016854,GO:0016857,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050897 5.1.3.30,5.1.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 398.0
TLS2_k127_6313555_9 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 394.0
TLS2_k127_6371504_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.078e-219 694.0
TLS2_k127_6371504_1 Belongs to the AlaDH PNT family K00259 GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030312,GO:0036293,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009462 424.0
TLS2_k127_6371504_2 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000005668 239.0
TLS2_k127_6371504_3 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000002222 150.0
TLS2_k127_6371504_4 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000005604 130.0
TLS2_k127_6371504_5 May be involved in recombinational repair of damaged DNA K03631 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000007494 74.0
TLS2_k127_6371504_6 TIGRFAM Sporulation protein YteA - - - 0.000000000007037 74.0
TLS2_k127_6403214_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0 1600.0
TLS2_k127_6403214_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0 1553.0
TLS2_k127_6403214_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 1.161e-296 926.0
TLS2_k127_6403214_3 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 329.0
TLS2_k127_6403214_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000472 215.0
TLS2_k127_6403214_5 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000002355 205.0
TLS2_k127_6403214_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000002592 146.0
TLS2_k127_6403214_7 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000001284 74.0
TLS2_k127_6450194_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 1.034e-235 757.0
TLS2_k127_6450194_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 600.0
TLS2_k127_6450194_10 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000007653 127.0
TLS2_k127_6450194_11 Type IV leader peptidase family - - - 0.00000000000000000000002159 109.0
TLS2_k127_6450194_12 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000645 92.0
TLS2_k127_6450194_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.6.5,3.1.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006743 511.0
TLS2_k127_6450194_3 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 435.0
TLS2_k127_6450194_4 tRNA synthetase class II core domain (G, H, P, S and T) K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003693 343.0
TLS2_k127_6450194_5 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000001383 237.0
TLS2_k127_6450194_6 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000406 213.0
TLS2_k127_6450194_7 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000008073 214.0
TLS2_k127_6450194_8 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000004055 171.0
TLS2_k127_6450194_9 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000883 123.0
TLS2_k127_6551146_0 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007315 454.0
TLS2_k127_6551146_1 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 406.0
TLS2_k127_6551146_2 ABC-type dipeptide transport system periplasmic component K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 385.0
TLS2_k127_6551146_3 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005386 310.0
TLS2_k127_6551146_4 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002088 229.0
TLS2_k127_6551146_5 Beta-lactamase superfamily domain - - - 0.00000000000000000003595 98.0
TLS2_k127_6567418_0 ABC transporter related K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 565.0
TLS2_k127_6567418_1 C-terminal, D2-small domain, of ClpB protein K03696 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 484.0
TLS2_k127_6567418_2 ABC transporter substrate-binding protein PnrA-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004518 324.0
TLS2_k127_6567418_3 queuosine salvage K09125 - - 0.00000000000000000000000000000000000000000000000000000000006088 214.0
TLS2_k127_6567418_4 Protein of unknown function (DUF559) - - - 0.0000000000000000000008909 106.0
TLS2_k127_6567418_5 D-alanyl-D-alanine carboxypeptidase - - - 0.000000000000000003196 93.0
TLS2_k127_6585600_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005174 501.0
TLS2_k127_6585600_1 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004058 469.0
TLS2_k127_6585600_2 HMGL-like K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000007869 273.0
TLS2_k127_6585600_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000001087 261.0
TLS2_k127_6585600_4 Pfam:PNPOx_C K00275 - 1.4.3.5 0.000000000000000000000000000000000000000000000000000000000000000003901 234.0
TLS2_k127_6585600_5 Metal-dependent hydrolases of the beta-lactamase superfamily III - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 - 0.000000000000000000000000000000000000000000000904 175.0
TLS2_k127_6585600_6 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000744 164.0
TLS2_k127_6585600_7 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.000000000000000000000000000000003802 141.0
TLS2_k127_6585600_8 Protein of unknown function (DUF983) - - - 0.000000000000000000000001873 111.0
TLS2_k127_6602906_0 ABC-type sugar transport system, ATPase component K10441 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 597.0
TLS2_k127_6602906_1 Protein of unknown function (DUF2867) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 512.0
TLS2_k127_6602906_2 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 342.0
TLS2_k127_6602906_3 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007548 323.0
TLS2_k127_6602906_4 membrane - - - 0.0000000000000000000000000000000000000008705 157.0
TLS2_k127_6602906_5 Protein of unknown function (DUF1475) - - - 0.00000000000002646 78.0
TLS2_k127_662143_0 Probable RNA and SrmB- binding site of polymerase A K00970,K00974 - 2.7.7.19,2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 489.0
TLS2_k127_662143_1 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006559 438.0
TLS2_k127_662143_10 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000001485 164.0
TLS2_k127_662143_11 PFAM Endonuclease Exonuclease phosphatase - - - 0.0000000000000000000000000000000000000002966 161.0
TLS2_k127_662143_12 TIGRFAM channel protein, hemolysin III family K11068 - - 0.00000001332 57.0
TLS2_k127_662143_2 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 422.0
TLS2_k127_662143_3 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004152 402.0
TLS2_k127_662143_4 Binding-protein-dependent transport system inner membrane component K02029 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 362.0
TLS2_k127_662143_5 ABC transporter K02028,K09972 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 350.0
TLS2_k127_662143_6 Pfam Amidohydrolase K20810 - 3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 332.0
TLS2_k127_662143_7 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 316.0
TLS2_k127_662143_8 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 302.0
TLS2_k127_662143_9 ABC transporter substrate-binding protein K02030,K02424,K17073 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003726 251.0
TLS2_k127_6632226_0 Hemerythrin HHE cation binding domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000002715 265.0
TLS2_k127_6632226_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000003295 235.0
TLS2_k127_6632226_2 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000002594 142.0
TLS2_k127_6650008_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.234e-218 696.0
TLS2_k127_6650008_1 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 481.0
TLS2_k127_6650008_10 alpha-ribazole phosphatase activity K15634 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000573 246.0
TLS2_k127_6650008_11 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000415 115.0
TLS2_k127_6650008_2 pfkB family carbohydrate kinase K03338 - 2.7.1.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 404.0
TLS2_k127_6650008_3 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009809 382.0
TLS2_k127_6650008_4 deoxyribose-phosphate aldolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 343.0
TLS2_k127_6650008_5 PFAM extracellular solute-binding protein, family 5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 336.0
TLS2_k127_6650008_6 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 314.0
TLS2_k127_6650008_7 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005943 303.0
TLS2_k127_6650008_8 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000014 277.0
TLS2_k127_6650008_9 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001014 260.0
TLS2_k127_6680914_0 PFAM Xanthine uracil vitamin C permease K06901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 416.0
TLS2_k127_6680914_1 ABC transporter K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 334.0
TLS2_k127_6680914_10 Nitroreductase family - - - 0.00000000000000000000006039 104.0
TLS2_k127_6680914_11 Branched-chain amino acid transport protein (AzlD) - - - 0.0000000000000000000003964 103.0
TLS2_k127_6680914_12 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000001526 77.0
TLS2_k127_6680914_2 NMT1/THI5 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 339.0
TLS2_k127_6680914_3 phosphorylase K03784 GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0034641,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:1901360 2.4.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006984 321.0
TLS2_k127_6680914_4 AzlC protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001146 265.0
TLS2_k127_6680914_5 B3/4 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002298 247.0
TLS2_k127_6680914_6 Amidinotransferase K01482 - 3.5.3.18 0.0000000000000000000000000000000000000000000000000000003332 202.0
TLS2_k127_6680914_7 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000002899 160.0
TLS2_k127_6680914_8 FCD - - - 0.000000000000000000000000000000000003201 147.0
TLS2_k127_6680914_9 - - - - 0.00000000000000000000000009099 112.0
TLS2_k127_6682314_0 associated with various cellular activities K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 369.0
TLS2_k127_6682314_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 368.0
TLS2_k127_6682314_2 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000001416 182.0
TLS2_k127_6682314_3 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000000008226 155.0
TLS2_k127_6682314_4 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000004146 117.0
TLS2_k127_6682314_5 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000000000002476 81.0
TLS2_k127_6682314_6 phosphoglycerate mutase - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000001337 79.0
TLS2_k127_6682314_7 HNH endonuclease - - - 0.00000001807 57.0
TLS2_k127_6682314_8 Protein of unknown function (DUF3040) - - - 0.0000143 51.0
TLS2_k127_6682314_9 Phosphoglycerate mutase family - - - 0.0002938 48.0
TLS2_k127_6696073_0 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 360.0
TLS2_k127_6696073_1 YibE F family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001544 292.0
TLS2_k127_6696073_2 Cytidine monophosphokinase K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000001057 244.0
TLS2_k127_6696073_3 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000003318 244.0
TLS2_k127_6696073_4 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000412 220.0
TLS2_k127_6696073_5 Pfam:DUF385 - - - 0.00000000000000000000005309 104.0
TLS2_k127_6696073_6 ArsR family transcriptional regulator - - - 0.00000000000000000002284 98.0
TLS2_k127_6696073_7 Domain of unknown function (DUF4388) - - - 0.000008563 57.0
TLS2_k127_6722416_0 Uncharacterized protein family (UPF0051) K09014 - - 6.049e-224 701.0
TLS2_k127_6722416_1 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009701 531.0
TLS2_k127_6722416_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001836 253.0
TLS2_k127_6722416_3 Response regulator receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003853 241.0
TLS2_k127_6722416_4 Trypsin K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000009682 191.0
TLS2_k127_6722416_5 D-alanyl-D-alanine carboxypeptidase - - - 0.000000000000000000000000000000000000000000000001706 183.0
TLS2_k127_6722416_6 heme binding K21472 - - 0.000000000000000000001051 103.0
TLS2_k127_6722416_7 - - - - 0.00000009651 59.0
TLS2_k127_6738139_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003757 331.0
TLS2_k127_6738139_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 326.0
TLS2_k127_6738139_3 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000002014 179.0
TLS2_k127_6738139_4 - - - - 0.00000000000000000000000000000000002549 147.0
TLS2_k127_6739930_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 443.0
TLS2_k127_6739930_1 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000004781 267.0
TLS2_k127_6739930_10 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000609 133.0
TLS2_k127_6739930_11 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000000002822 74.0
TLS2_k127_6739930_12 Ribosomal protein L30p/L7e K02907 - - 0.000000000003279 70.0
TLS2_k127_6739930_2 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007197 245.0
TLS2_k127_6739930_3 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000006542 228.0
TLS2_k127_6739930_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000002349 216.0
TLS2_k127_6739930_5 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000003256 213.0
TLS2_k127_6739930_6 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000003658 187.0
TLS2_k127_6739930_7 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000001623 183.0
TLS2_k127_6739930_8 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000000000000001203 163.0
TLS2_k127_6739930_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000004665 157.0
TLS2_k127_6762616_0 Cupin superfamily protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 328.0
TLS2_k127_6762616_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001327 244.0
TLS2_k127_6762616_2 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000006289 222.0
TLS2_k127_6762616_3 Sucrase/ferredoxin-like - - - 0.000000000000000000000000000000000000000000000000000000000004412 220.0
TLS2_k127_6762616_4 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000002969 207.0
TLS2_k127_6762616_5 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000006347 215.0
TLS2_k127_6762616_6 InterPro IPR014922 - - - 0.000000000000000000000000000000000000000000000000024 185.0
TLS2_k127_6762616_7 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000008424 173.0
TLS2_k127_6762616_8 Sporulation and spore germination - - - 0.0000000000000000000000000000000000007913 153.0
TLS2_k127_6762616_9 pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000005625 136.0
TLS2_k127_6767840_0 Belongs to the complex I 49 kDa subunit family K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 457.0
TLS2_k127_6767840_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000201 262.0
TLS2_k127_6767840_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00332 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000000000000000000003944 146.0
TLS2_k127_6767840_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000004557 149.0
TLS2_k127_6767840_4 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.4.1.1 0.0000000000000000000000000000000006554 136.0
TLS2_k127_6767840_5 Psort location Cytoplasmic, score - - - 0.000000003035 63.0
TLS2_k127_6768617_0 helicase activity - - - 2.314e-214 690.0
TLS2_k127_6768617_1 ABC transporter transmembrane region K02021,K06147,K16786,K16787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 501.0
TLS2_k127_6768617_10 Alkylmercury lyase - - - 0.000000001617 61.0
TLS2_k127_6768617_11 Flp Fap pilin component K02651 - - 0.0004005 51.0
TLS2_k127_6768617_2 ABC transporter, transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 468.0
TLS2_k127_6768617_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005069 296.0
TLS2_k127_6768617_4 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000003698 216.0
TLS2_k127_6768617_5 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000002644 199.0
TLS2_k127_6768617_6 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.00000000000000000000000000000002078 137.0
TLS2_k127_6768617_7 Transketolase, C-terminal domain K00162 - 1.2.4.1 0.000000000000000000000000002969 114.0
TLS2_k127_6768617_8 PFAM CBS domain - - - 0.000000000000000002217 93.0
TLS2_k127_6768617_9 Alkylmercury lyase - - - 0.000000000000989 76.0
TLS2_k127_6780461_0 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006044 546.0
TLS2_k127_6780461_1 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 395.0
TLS2_k127_6780461_10 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000002142 63.0
TLS2_k127_6780461_2 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 362.0
TLS2_k127_6780461_3 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002815 267.0
TLS2_k127_6780461_4 ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000001416 224.0
TLS2_k127_6780461_5 Belongs to the binding-protein-dependent transport system permease family K01997,K01999 - - 0.0000000000000000000000000000000000000000000000000000007825 207.0
TLS2_k127_6780461_6 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000000000000000000001219 205.0
TLS2_k127_6780461_7 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000002777 186.0
TLS2_k127_6780461_8 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000005333 148.0
TLS2_k127_6780461_9 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000002298 112.0
TLS2_k127_6791024_0 COG1960 Acyl-CoA dehydrogenases K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 504.0
TLS2_k127_6791024_1 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 389.0
TLS2_k127_6791024_2 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005415 361.0
TLS2_k127_6791024_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 339.0
TLS2_k127_6791024_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 306.0
TLS2_k127_6791024_5 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 294.0
TLS2_k127_6791024_6 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000002037 222.0
TLS2_k127_6798490_0 Aldo/keto reductase family K19265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007831 500.0
TLS2_k127_6798490_1 Kynurenine--oxoglutarate transaminase - GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 452.0
TLS2_k127_6798490_2 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 351.0
TLS2_k127_6798490_3 transport, permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000001731 234.0
TLS2_k127_6798490_4 Sap, sulfolipid-1-addressing protein - - - 0.000000000000000000000000000000000000000000000000000000001834 207.0
TLS2_k127_6798490_5 F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000232 186.0
TLS2_k127_6798490_6 F420H(2)-dependent quinone reductase - GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0030312,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 - 0.00000000000000000000000000000004511 129.0
TLS2_k127_6798490_7 Belongs to the universal stress protein A family - - - 0.00000000003305 73.0
TLS2_k127_6804824_0 Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 568.0
TLS2_k127_6804824_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000507 478.0
TLS2_k127_6804824_10 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000001772 256.0
TLS2_k127_6804824_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000015 231.0
TLS2_k127_6804824_12 ABC transporter, ATP-binding protein K02052,K02062 - - 0.00000000000000000000000000000000000000000000000000000000000002177 223.0
TLS2_k127_6804824_13 ANTAR domain protein - - - 0.00000000000000000000000000000000000000000000000000000000004689 213.0
TLS2_k127_6804824_14 DNA synthesis involved in DNA repair - - - 0.00000000000000000000000000000000000000000000005608 186.0
TLS2_k127_6804824_15 NAD(P) transhydrogenase, alpha subunit K00324 - 1.6.1.2 0.00000000000000000000000000000001694 128.0
TLS2_k127_6804824_18 ANTAR - - - 0.0000000000000001368 90.0
TLS2_k127_6804824_19 IQR COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000001348 74.0
TLS2_k127_6804824_2 ABC-type Fe3 transport system permease component K02011,K02063 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 463.0
TLS2_k127_6804824_20 PFAM Integrase catalytic - - - 0.0000000000001162 72.0
TLS2_k127_6804824_21 Thioesterase-like superfamily K07107 - - 0.0000000000004072 74.0
TLS2_k127_6804824_22 Fasciclin - - - 0.0000000007401 68.0
TLS2_k127_6804824_23 STAS domain K06378 - - 0.000008448 53.0
TLS2_k127_6804824_24 Zinc-binding dehydrogenase K13953 - 1.1.1.1 0.0001754 45.0
TLS2_k127_6804824_25 PFAM Integrase catalytic - - - 0.0002789 50.0
TLS2_k127_6804824_3 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 444.0
TLS2_k127_6804824_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007737 385.0
TLS2_k127_6804824_5 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009017 366.0
TLS2_k127_6804824_6 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004167 353.0
TLS2_k127_6804824_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 321.0
TLS2_k127_6804824_8 ABC transporter, periplasmic binding protein, thiB subfamily K02064 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005223 314.0
TLS2_k127_6804824_9 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 301.0
TLS2_k127_6827015_0 4Fe-4S dicluster domain - - - 3.387e-231 730.0
TLS2_k127_6827015_1 ATP-dependent Clp protease adaptor protein ClpS K06891 - - 0.00000000000000000000000000000002401 127.0
TLS2_k127_6827015_2 translation release factor activity - - - 0.0000000000000000000000003837 118.0
TLS2_k127_6827015_3 Domain of unknown function (DUF4332) - - - 0.0000000000000000000000005947 109.0
TLS2_k127_6827015_4 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.000000000000000000000001446 110.0
TLS2_k127_6827015_5 Domain of unknown function (DUF2017) - - - 0.00000000001817 71.0
TLS2_k127_6827015_6 - - - - 0.000001929 59.0
TLS2_k127_6829707_0 4-hydroxybenzoate K00481 - 1.14.13.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 494.0
TLS2_k127_6829707_1 trisaccharide binding K03556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 509.0
TLS2_k127_6829707_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000001521 224.0
TLS2_k127_6829707_11 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756,K01857 - 4.3.2.2,5.5.1.2 0.000000000000000000000000000000000000000000000000000000000001386 226.0
TLS2_k127_6829707_12 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000006186 219.0
TLS2_k127_6829707_13 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000009848 221.0
TLS2_k127_6829707_14 PFAM Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000003399 218.0
TLS2_k127_6829707_15 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000001224 216.0
TLS2_k127_6829707_16 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000000000000733 199.0
TLS2_k127_6829707_17 Prolyl oligopeptidase family K06889 - - 0.00000000000000000000000000000000000000000000000000003014 202.0
TLS2_k127_6829707_18 Dioxygenase K00448 - 1.13.11.3 0.000000000000000000000000000000000000000000000000006192 188.0
TLS2_k127_6829707_19 CAAX protease self-immunity - - - 0.000000000000000000000000000000000000001439 159.0
TLS2_k127_6829707_2 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 399.0
TLS2_k127_6829707_20 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000003128 155.0
TLS2_k127_6829707_21 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.00000000000000000000000000000000000001468 149.0
TLS2_k127_6829707_22 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000001195 132.0
TLS2_k127_6829707_23 CAAX protease self-immunity K07052 - - 0.000000000000000000000000009808 120.0
TLS2_k127_6829707_24 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000001079 118.0
TLS2_k127_6829707_25 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000003581 109.0
TLS2_k127_6829707_26 Pfam:DUF385 - - - 0.00000000000000000008331 95.0
TLS2_k127_6829707_27 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000001142 75.0
TLS2_k127_6829707_28 Alpha/beta-hydrolase family N-terminus - - - 0.000000000007406 69.0
TLS2_k127_6829707_29 Protein of unknown function (DUF1761) - - - 0.0000000003586 66.0
TLS2_k127_6829707_3 C4-dicarboxylate ABC transporter permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005065 401.0
TLS2_k127_6829707_30 hyperosmotic response K04065 - - 0.0000009965 56.0
TLS2_k127_6829707_31 - - - - 0.0001125 48.0
TLS2_k127_6829707_33 - - - - 0.000417 49.0
TLS2_k127_6829707_4 Coenzyme A transferase K01040 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 344.0
TLS2_k127_6829707_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648,K18003 - 2.3.1.180,2.3.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 333.0
TLS2_k127_6829707_6 Transcriptional regulator K02624 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002376 287.0
TLS2_k127_6829707_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001112 279.0
TLS2_k127_6829707_8 Protocatechuate 3,4-dioxygenase beta subunit N terminal K00449 - 1.13.11.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000005025 275.0
TLS2_k127_6829707_9 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004169 256.0
TLS2_k127_6830793_0 Adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005795 587.0
TLS2_k127_6830793_1 Inosine-uridine preferring nucleoside hydrolase K01239 GO:0003674,GO:0003824,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008655,GO:0009056,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009164,GO:0009165,GO:0009435,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019357,GO:0019358,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0034356,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0045437,GO:0046135,GO:0046483,GO:0046496,GO:0046497,GO:0046700,GO:0050263,GO:0051186,GO:0051188,GO:0055086,GO:0070635,GO:0070636,GO:0071704,GO:0072521,GO:0072523,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.2.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 398.0
TLS2_k127_6830793_2 ABC transporter transmembrane region K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000887 281.0
TLS2_k127_6830793_3 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000008776 248.0
TLS2_k127_6830793_4 N-acetylmuramoyl-L-alanine amidase - - - 0.00000000000000000000000000000000002413 149.0
TLS2_k127_6830793_5 Histidine kinase - - - 0.00000000000000000000000000008007 134.0
TLS2_k127_6830793_6 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K00663,K03790 - 2.3.1.128,2.3.1.82 0.00000000000000000003638 92.0
TLS2_k127_6830793_7 Belongs to the peptidase S8 family - - - 0.00000000000000000004074 103.0
TLS2_k127_6830793_8 Transglycosylase SLT domain - - - 0.000000002416 65.0
TLS2_k127_6835797_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 2843.0
TLS2_k127_6835797_1 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007683 288.0
TLS2_k127_6835797_2 Toxic component of a toxin-antitoxin (TA) module K07171 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.000000000000000000000000000000000000000000004274 164.0
TLS2_k127_6835797_3 50S ribosome-binding GTPase - - - 0.00000000000000000000000000000000000000000194 175.0
TLS2_k127_6886228_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007928 488.0
TLS2_k127_6886228_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 421.0
TLS2_k127_6886228_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 404.0
TLS2_k127_6886228_3 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 344.0
TLS2_k127_6886228_4 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000004388 281.0
TLS2_k127_6886228_5 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000007765 156.0
TLS2_k127_6886228_6 YCII-related domain - - - 0.00000000000000000000000000000001374 138.0
TLS2_k127_6886228_7 membrane - - - 0.00000000000000000000006534 106.0
TLS2_k127_6886228_8 sterol carrier protein - - - 0.0000001424 58.0
TLS2_k127_6927995_0 Dihydropyrimidinase K01464 - 3.5.2.2 2.405e-205 651.0
TLS2_k127_6927995_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00140,K00823 - 1.2.1.18,1.2.1.27,2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008897 584.0
TLS2_k127_6927995_10 regulatory protein GntR HTH K03710 - - 0.0000000000000000000000000000000000000000000002918 179.0
TLS2_k127_6927995_11 2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase K01625 - 4.1.2.14,4.1.3.42 0.000000000000000000000000000000000001306 152.0
TLS2_k127_6927995_12 PFAM Aldehyde dehydrogenase family K00128,K00135,K22187 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 0.00000000003298 64.0
TLS2_k127_6927995_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 488.0
TLS2_k127_6927995_3 Phenazine biosynthesis protein PhzF - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 318.0
TLS2_k127_6927995_4 protein containing SIS (Sugar isomerase) phosphosugar binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 310.0
TLS2_k127_6927995_5 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000356 262.0
TLS2_k127_6927995_6 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431 - 3.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000003068 238.0
TLS2_k127_6927995_7 Bacterial low temperature requirement A protein (LtrA) - - - 0.000000000000000000000000000000000000000000000000000000000000000009553 240.0
TLS2_k127_6927995_8 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000002656 233.0
TLS2_k127_6927995_9 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000001336 230.0
TLS2_k127_6934958_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 602.0
TLS2_k127_6934958_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008623 279.0
TLS2_k127_6934958_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000002908 255.0
TLS2_k127_6934958_5 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.0002061 44.0
TLS2_k127_6967123_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 4.2.1.9 2.229e-227 717.0
TLS2_k127_6967123_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 452.0
TLS2_k127_6967123_2 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 319.0
TLS2_k127_6967123_3 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009742 321.0
TLS2_k127_6967123_4 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000002074 250.0
TLS2_k127_6967123_5 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000001629 217.0
TLS2_k127_6967123_6 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.000000000000000000000000000000000002575 141.0
TLS2_k127_6967123_7 universal stress protein - - - 0.0000000000000000000001386 108.0
TLS2_k127_6967123_8 RDD family - - - 0.0000000005735 70.0
TLS2_k127_702118_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009241 595.0
TLS2_k127_702118_1 import. Responsible for energy coupling to the transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007928 425.0
TLS2_k127_702118_10 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.000000000000000000000000000000000000000000000000000000001198 214.0
TLS2_k127_702118_11 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000000000003266 199.0
TLS2_k127_702118_12 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000001421 202.0
TLS2_k127_702118_13 Belongs to the arylamine N-acetyltransferase family K00675 - 2.3.1.118 0.000000000000000000000000000000000000000004059 165.0
TLS2_k127_702118_14 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.1.11.6 0.00000000000000000000000000000000000001008 155.0
TLS2_k127_702118_15 Amidohydrolase family - - - 0.0000000000000000000000000000002045 129.0
TLS2_k127_702118_16 Roadblock lc7 family protein K07131 - - 0.000000000000000000000000000001107 127.0
TLS2_k127_702118_17 response regulator, receiver - - - 0.000000000000000000001607 109.0
TLS2_k127_702118_18 Histidine kinase - - - 0.0000000000000009227 89.0
TLS2_k127_702118_19 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000001145 83.0
TLS2_k127_702118_2 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004257 421.0
TLS2_k127_702118_20 Protein of unknown function (DUF742) - - - 0.000008098 56.0
TLS2_k127_702118_21 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0001444 49.0
TLS2_k127_702118_22 Predicted integral membrane protein (DUF2269) - - - 0.0001502 50.0
TLS2_k127_702118_23 - - - - 0.0002643 53.0
TLS2_k127_702118_3 Epoxide hydrolase N terminus K21159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 351.0
TLS2_k127_702118_4 PFAM NmrA family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 305.0
TLS2_k127_702118_5 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000582 280.0
TLS2_k127_702118_6 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001878 284.0
TLS2_k127_702118_7 ATP- GTP-binding protein K06945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001057 248.0
TLS2_k127_702118_8 Periplasmic binding protein domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004206 238.0
TLS2_k127_702118_9 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000007338 233.0
TLS2_k127_7038521_0 trisaccharide binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 371.0
TLS2_k127_7038521_1 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000000000000003991 135.0
TLS2_k127_7038521_3 - - - - 0.000000000000000000000000000001295 127.0
TLS2_k127_7038521_4 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 0.000000003247 61.0
TLS2_k127_7038521_5 PFAM Uncharacterised protein family UPF0150 - - - 0.0002645 47.0
TLS2_k127_7085349_0 Belongs to the ATCase OTCase family K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006021 475.0
TLS2_k127_7085349_1 NAT, N-acetyltransferase, of N-acetylglutamate synthase K22478 - 2.3.1.1,2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008104 467.0
TLS2_k127_7085349_2 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00756,K00758 - 2.4.2.2,2.4.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 447.0
TLS2_k127_7085349_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 332.0
TLS2_k127_7085349_4 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001533 276.0
TLS2_k127_7085349_5 Protein of unknown function (DUF541) K09807 - - 0.000000000000000000000001992 112.0
TLS2_k127_7085349_6 Protein of unknown function (DUF664) - - - 0.000000000000001082 83.0
TLS2_k127_7085349_7 DNA-templated transcription, initiation K03088 - - 0.0009065 44.0
TLS2_k127_7108200_0 methionine synthase K00544,K00548 - 2.1.1.13,2.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004591 487.0
TLS2_k127_7108200_1 kynureninase activity K01556 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0019439,GO:0019441,GO:0019752,GO:0030429,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008442 412.0
TLS2_k127_7108200_10 Ion transport 2 domain protein K10716 - - 0.0000001558 56.0
TLS2_k127_7108200_2 Amidohydrolase family - - - 0.000000000000000000000000000000000005831 139.0
TLS2_k127_7108200_3 protein conserved in bacteria - - - 0.0000000000000000000000000001466 122.0
TLS2_k127_7108200_4 - - - - 0.0000000000000000004556 93.0
TLS2_k127_7108200_5 - - - - 0.00000000000003743 79.0
TLS2_k127_7108200_6 - - - - 0.0000000000002048 74.0
TLS2_k127_7108200_7 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.000000000005037 70.0
TLS2_k127_7108200_8 Terminase RNaseH-like domain - - - 0.0000000007539 64.0
TLS2_k127_7108200_9 antisigma factor binding K04749 - - 0.00000002019 59.0
TLS2_k127_7148265_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008437 429.0
TLS2_k127_7148265_1 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 376.0
TLS2_k127_7148265_10 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001311 300.0
TLS2_k127_7148265_11 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005733 265.0
TLS2_k127_7148265_12 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001013 259.0
TLS2_k127_7148265_13 PFAM PHP domain K07053,K20859 - 3.1.3.97,3.1.4.57 0.00000000000000000000000000000000000000000000000000000000000000000007482 240.0
TLS2_k127_7148265_14 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000004268 205.0
TLS2_k127_7148265_15 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000004875 219.0
TLS2_k127_7148265_16 phosphatase activity K05967 - - 0.000000000000000000000000000000000000000000000000000000678 198.0
TLS2_k127_7148265_17 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000000004529 195.0
TLS2_k127_7148265_18 organic phosphonate transmembrane transporter activity K02042 - - 0.00000000000000000000000000000000000000000000000007017 201.0
TLS2_k127_7148265_19 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000002554 182.0
TLS2_k127_7148265_2 SMART Metal-dependent phosphohydrolase, HD region K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007036 376.0
TLS2_k127_7148265_20 Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000000000000000000000000001201 151.0
TLS2_k127_7148265_21 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.000000000000000000000000000000000001824 148.0
TLS2_k127_7148265_22 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000001404 108.0
TLS2_k127_7148265_23 transcriptional regulator - - - 0.0000000000000000000765 89.0
TLS2_k127_7148265_24 PhoU domain - - - 0.0000000000004774 78.0
TLS2_k127_7148265_25 Helix-turn-helix domain - - - 0.000002783 56.0
TLS2_k127_7148265_3 Fructose-1,6-bisphosphatase K02446 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 370.0
TLS2_k127_7148265_4 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 337.0
TLS2_k127_7148265_5 Na+/Pi-cotransporter K03324,K14683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 335.0
TLS2_k127_7148265_6 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003898 324.0
TLS2_k127_7148265_7 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 311.0
TLS2_k127_7148265_8 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 315.0
TLS2_k127_7148265_9 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 299.0
TLS2_k127_7187065_0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 616.0
TLS2_k127_7187065_1 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 461.0
TLS2_k127_7187065_10 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00006689 49.0
TLS2_k127_7187065_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006919 255.0
TLS2_k127_7187065_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000002051 173.0
TLS2_k127_7187065_4 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000003817 180.0
TLS2_k127_7187065_5 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000001124 147.0
TLS2_k127_7187065_6 Signal transduction histidine kinase - - - 0.000000000000000008226 97.0
TLS2_k127_7187065_7 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000004511 91.0
TLS2_k127_7187065_9 helix_turn_helix, Lux Regulon - - - 0.00000001457 59.0
TLS2_k127_7202534_0 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 454.0
TLS2_k127_7202534_1 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 428.0
TLS2_k127_7202534_10 PFAM pyridoxamine 5'-phosphate oxidase-related - - - 0.0000000000000000000000008488 108.0
TLS2_k127_7202534_11 Concanavalin A-like lectin/glucanases superfamily K12287 - - 0.00000001373 67.0
TLS2_k127_7202534_12 Domain of unknown function (DUF1992) - - - 0.000004329 51.0
TLS2_k127_7202534_2 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 367.0
TLS2_k127_7202534_3 Peptidase family M20/M25/M40 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006316 347.0
TLS2_k127_7202534_4 Peptidase family M20/M25/M40 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003903 336.0
TLS2_k127_7202534_5 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.00000000000000000000000000000000000000000000000000000005516 200.0
TLS2_k127_7202534_6 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively K01243 - 3.2.2.9 0.0000000000000000000000000000000000000000000000000007672 194.0
TLS2_k127_7202534_7 OsmC-like protein K04063 - - 0.000000000000000000000000000000000000000000001824 168.0
TLS2_k127_7202534_8 CGNR zinc finger - - - 0.000000000000000000000000004309 119.0
TLS2_k127_7202534_9 Histidine kinase K07636 - 2.7.13.3 0.0000000000000000000000003508 120.0
TLS2_k127_7232030_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1103.0
TLS2_k127_7232030_1 Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 352.0
TLS2_k127_7232030_11 - - - - 0.0003446 50.0
TLS2_k127_7232030_2 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000361 266.0
TLS2_k127_7232030_3 Activator of Hsp90 ATPase 1 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000001029 235.0
TLS2_k127_7232030_4 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000007542 192.0
TLS2_k127_7232030_5 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000006906 191.0
TLS2_k127_7232030_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000007075 166.0
TLS2_k127_7232030_7 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000007329 147.0
TLS2_k127_7232030_8 transcriptional - - - 0.000000000000000001199 96.0
TLS2_k127_7232030_9 JAB/MPN domain K21140 - 3.13.1.6 0.000000000003227 74.0
TLS2_k127_7285272_0 Glutamine synthetase, beta-Grasp domain K01915 GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 7.476e-232 724.0
TLS2_k127_7285272_1 Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008092 413.0
TLS2_k127_7285272_2 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000001153 221.0
TLS2_k127_7285272_3 transcriptional regulator - - - 0.00000000000000000000000000000000000465 139.0
TLS2_k127_7285272_4 DNA alkylation repair - - - 0.0000000000000004794 86.0
TLS2_k127_7285272_5 HIRA-interacting protein K22074 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0031974,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051604,GO:0070013,GO:0071704,GO:0097428,GO:0106035,GO:1901564 - 0.0000000000001773 73.0
TLS2_k127_7289551_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1262.0
TLS2_k127_7289551_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 451.0
TLS2_k127_7289551_10 AAA domain - - - 0.00000000000000000000000000000718 125.0
TLS2_k127_7289551_11 integration host factor - - - 0.00000000000000000000000002484 114.0
TLS2_k127_7289551_12 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000000000000001017 101.0
TLS2_k127_7289551_13 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 GO:0008150,GO:0040007 - 0.0000000000000001088 87.0
TLS2_k127_7289551_14 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000005211 74.0
TLS2_k127_7289551_2 Belongs to the CarA family K01955,K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 379.0
TLS2_k127_7289551_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 336.0
TLS2_k127_7289551_4 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 324.0
TLS2_k127_7289551_5 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000003439 264.0
TLS2_k127_7289551_6 Catalyzes the conversion of dihydroorotate to orotate K00254,K17828 - 1.3.1.14,1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000354 229.0
TLS2_k127_7289551_7 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000001372 205.0
TLS2_k127_7289551_8 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000003377 192.0
TLS2_k127_7289551_9 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000002732 165.0
TLS2_k127_7297008_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 2.611e-215 678.0
TLS2_k127_7297008_1 Psort location CytoplasmicMembrane, score 10.00 K03458 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 469.0
TLS2_k127_7297008_2 Carbon-nitrogen hydrolase K01431 - 3.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001387 280.0
TLS2_k127_7297008_3 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.00000000000000000000000000000000000000000000000006691 188.0
TLS2_k127_7297008_4 Domain of unknown function (DUF1992) - - - 0.0000000000007549 70.0
TLS2_k127_7419048_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 9.193e-255 798.0
TLS2_k127_7419048_1 Beta-glucosidase K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 479.0
TLS2_k127_7419048_2 Involved in the biosynthesis of porphyrin-containing compound - GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002285 281.0
TLS2_k127_7419048_3 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000002646 187.0
TLS2_k127_7419048_4 COG0285 Folylpolyglutamate synthase K00796 - 2.5.1.15 0.0000000000000000000000000000000001223 143.0
TLS2_k127_7419048_5 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000807 79.0
TLS2_k127_7419048_6 DNA polymerase III delta subunit K02340 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0001162 54.0
TLS2_k127_74723_0 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 422.0
TLS2_k127_74723_1 Domain of unknown function (DUF4389) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007044 393.0
TLS2_k127_74723_2 pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 353.0
TLS2_k127_74723_3 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000000000000000008541 205.0
TLS2_k127_74723_4 F420H(2)-dependent quinone reductase - - - 0.0000000000000000000000000000000000000000000000001008 186.0
TLS2_k127_74723_5 Two component transcriptional regulator, LuxR family - - - 0.00001498 54.0
TLS2_k127_784119_0 Dehydrogenase K00004,K00060,K08322 GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0030246,GO:0042221,GO:0044238,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701 1.1.1.103,1.1.1.303,1.1.1.380,1.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 540.0
TLS2_k127_784119_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002286 291.0
TLS2_k127_784119_2 hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000002977 231.0
TLS2_k127_784119_3 Belongs to the UPF0301 (AlgH) family K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000001875 171.0
TLS2_k127_784119_4 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000001891 169.0
TLS2_k127_784119_5 Psort location Cytoplasmic, score K00760 - 2.4.2.8 0.0000000000000000000000000000003922 127.0
TLS2_k127_851433_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02827 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.10.3.12,1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 589.0
TLS2_k127_851433_1 PFAM FAD dependent oxidoreductase K00116,K15736 - 1.1.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 550.0
TLS2_k127_851433_10 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.00000000000249 72.0
TLS2_k127_851433_2 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 459.0
TLS2_k127_851433_3 F420-dependent oxidoreductase, MSMEG_2906 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008719 407.0
TLS2_k127_851433_4 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 403.0
TLS2_k127_851433_5 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009929 349.0
TLS2_k127_851433_6 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004824 315.0
TLS2_k127_851433_7 3-methyladenine DNA glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000001487 260.0
TLS2_k127_851433_8 Cytochrome c oxidase subunit III K02276,K02299 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 0.000000000000000000000000000000000000000000000000000000294 203.0
TLS2_k127_851433_9 PFAM oxidoreductase molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000006459 198.0
TLS2_k127_852773_0 Lanthionine synthetase C-like protein - - - 6.034e-222 717.0
TLS2_k127_852773_1 Pyridoxal-phosphate dependent enzyme K01505,K05396 - 3.5.99.7,4.4.1.15 2.352e-196 615.0
TLS2_k127_852773_10 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 364.0
TLS2_k127_852773_11 Alcohol dehydrogenase GroES-like domain K00004 - 1.1.1.303,1.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000007487 249.0
TLS2_k127_852773_12 4Fe-4S binding domain K05524 - - 0.000000000000000000000000000000000000000000000000000000000000000009552 226.0
TLS2_k127_852773_13 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000001052 232.0
TLS2_k127_852773_14 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000006233 227.0
TLS2_k127_852773_15 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01476,K01480 - 3.5.3.1,3.5.3.11 0.00000000000000000000000000000000000000000000000000000002894 207.0
TLS2_k127_852773_16 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000002154 199.0
TLS2_k127_852773_17 glutamine amidotransferase - - - 0.000000000000000000000000000000000000000000000000000002739 198.0
TLS2_k127_852773_18 HNH endonuclease - - - 0.00000000000000000000000000000000000000000000000000007985 198.0
TLS2_k127_852773_19 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000003567 181.0
TLS2_k127_852773_2 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 579.0
TLS2_k127_852773_20 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000000000000000000000000000000000000004416 168.0
TLS2_k127_852773_21 CHAT domain - - - 0.000000000000000000000000000000000000000001122 179.0
TLS2_k127_852773_22 protein involved in virulence - - - 0.00000000000000000000000000000000000002037 159.0
TLS2_k127_852773_23 peptidoglycan-binding domain-containing protein - - - 0.000000000000000000000000008542 124.0
TLS2_k127_852773_24 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.0000000000000000000000001575 116.0
TLS2_k127_852773_25 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000002249 101.0
TLS2_k127_852773_26 C-terminal four TMM region of protein-O-mannosyltransferase - - - 0.0000000000000000007449 95.0
TLS2_k127_852773_27 PFAM Cupin 2, conserved barrel - - - 0.00000000000001334 80.0
TLS2_k127_852773_28 Gcn5-related n-acetyltransferase K22476 - 2.3.1.1 0.0000000004918 69.0
TLS2_k127_852773_29 Protein of unknown function (DUF3156) - - - 0.000000005747 65.0
TLS2_k127_852773_3 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 516.0
TLS2_k127_852773_30 addiction module antidote protein, CC2985 family - - - 0.00009486 53.0
TLS2_k127_852773_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000629 502.0
TLS2_k127_852773_5 Alcohol dehydrogenase GroES-like domain K00001,K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 491.0
TLS2_k127_852773_6 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 483.0
TLS2_k127_852773_7 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005327 402.0
TLS2_k127_852773_8 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005085 372.0
TLS2_k127_852773_9 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 373.0
TLS2_k127_895134_0 Carboxyl transferase domain - - - 4.559e-225 708.0
TLS2_k127_895134_1 Acetyl propionyl-CoA carboxylase, alpha subunit K01959,K01965,K01968 - 6.4.1.1,6.4.1.3,6.4.1.4 5.215e-203 654.0
TLS2_k127_895134_10 Histidine kinase - - - 0.00000000000000004665 87.0
TLS2_k127_895134_11 lysyltransferase activity - - - 0.0000001202 63.0
TLS2_k127_895134_2 PFAM Aminotransferase class I and II K00639,K00652 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003454 487.0
TLS2_k127_895134_3 phosphogluconate dehydrogenase (decarboxylating) activity K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 336.0
TLS2_k127_895134_4 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000001351 180.0
TLS2_k127_895134_5 MaoC like domain - - - 0.0000000000000000000000000000000000000000001032 170.0
TLS2_k127_895134_6 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000001144 136.0
TLS2_k127_895134_7 ferredoxin K05337 - - 0.0000000000000000000000000000008684 123.0
TLS2_k127_895134_8 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000003849 112.0
TLS2_k127_895134_9 Protein of unknown function (DUF4230) - - - 0.00000000000000002402 90.0
TLS2_k127_926250_0 PFAM ABC transporter related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001403 277.0
TLS2_k127_926250_1 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000001242 244.0
TLS2_k127_926250_2 Competence-damaged protein K03742 - 3.5.1.42 0.00000000000000000000000000007807 126.0
TLS2_k127_926250_3 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 0.00000000000000000000001549 100.0
TLS2_k127_926250_4 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000007295 84.0
TLS2_k127_994137_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 512.0
TLS2_k127_994137_1 Endoribonuclease that initiates mRNA decay K18682 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 518.0
TLS2_k127_994137_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 462.0
TLS2_k127_994137_3 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 411.0
TLS2_k127_994137_4 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000003708 244.0
TLS2_k127_994137_5 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000003565 235.0
TLS2_k127_994137_6 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000001679 210.0
TLS2_k127_994137_7 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000914 203.0