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Overview

ID MAG03998
Name TLS2_bin.31
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Actinomycetota
Class Acidimicrobiia
Order UBA5794
Family ZC4RG35
Genus JARDZU01
Species
Assembly information
Completeness (%) 90.6
Contamination (%) 0.83
GC content (%) 64.0
N50 (bp) 47,770
Genome size (bp) 2,899,808

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2731

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1006775_0 Glycosyl Transferase - - - 1.137e-248 801.0
TLS2_k127_1006775_1 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 325.0
TLS2_k127_1006775_2 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000005532 225.0
TLS2_k127_1006775_3 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000004659 217.0
TLS2_k127_1006775_4 thiolester hydrolase activity - - - 0.000000000000000000000000000000000006942 147.0
TLS2_k127_1006775_5 Putative glycolipid-binding K09957 - - 0.0000000001064 64.0
TLS2_k127_102086_0 SMART alpha amylase, catalytic sub domain K05343 - 3.2.1.1,5.4.99.16 0.0 1256.0
TLS2_k127_102086_1 Methionine synthase K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0 1184.0
TLS2_k127_102086_10 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007257 546.0
TLS2_k127_102086_11 Belongs to the glycosyl hydrolase 1 family K05350 - 3.2.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 509.0
TLS2_k127_102086_12 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431 - 3.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006461 483.0
TLS2_k127_102086_13 5'-nucleotidase, C-terminal domain K01081,K01119 - 3.1.3.5,3.1.3.6,3.1.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 500.0
TLS2_k127_102086_14 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 507.0
TLS2_k127_102086_15 carbohydrate transport K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 473.0
TLS2_k127_102086_16 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 469.0
TLS2_k127_102086_17 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008402 392.0
TLS2_k127_102086_18 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 393.0
TLS2_k127_102086_19 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003888 389.0
TLS2_k127_102086_2 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 9.777e-294 915.0
TLS2_k127_102086_20 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 387.0
TLS2_k127_102086_21 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 394.0
TLS2_k127_102086_22 Belongs to the binding-protein-dependent transport system permease family K10440,K10441 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 372.0
TLS2_k127_102086_23 transmembrane transport K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17242,K17316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 331.0
TLS2_k127_102086_24 Homoserine dehydrogenase K00003,K12524 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.3,2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008859 327.0
TLS2_k127_102086_25 ABC-type nitrate sulfonate bicarbonate transport system ATPase component K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005084 320.0
TLS2_k127_102086_26 3-oxo-5-alpha-steroid 4-dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006543 289.0
TLS2_k127_102086_27 PFAM Fatty acid desaturase, type 2 K03921 - 1.14.19.11,1.14.19.2,1.14.19.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000007235 270.0
TLS2_k127_102086_28 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008619 283.0
TLS2_k127_102086_29 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003494 265.0
TLS2_k127_102086_3 glutamate synthase, alpha subunit domain protein K00284 - 1.4.7.1 2.126e-287 910.0
TLS2_k127_102086_30 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000001518 241.0
TLS2_k127_102086_31 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000001516 237.0
TLS2_k127_102086_32 Periplasmic binding protein domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001909 254.0
TLS2_k127_102086_33 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000174 228.0
TLS2_k127_102086_34 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000000002215 228.0
TLS2_k127_102086_35 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000001399 226.0
TLS2_k127_102086_36 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000001759 216.0
TLS2_k127_102086_37 inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000002579 216.0
TLS2_k127_102086_38 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000002333 221.0
TLS2_k127_102086_39 iron dependent repressor - - - 0.00000000000000000000000000000000000000000000000000003981 196.0
TLS2_k127_102086_4 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 1.591e-232 737.0
TLS2_k127_102086_40 RNA polymerase sigma K03090 GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000000000000000008304 186.0
TLS2_k127_102086_41 sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000001069 171.0
TLS2_k127_102086_42 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.000000000000000000000000000000000000000000001551 177.0
TLS2_k127_102086_43 PFAM Rhomboid family protein - - - 0.0000000000000000000000000000000000000000003077 167.0
TLS2_k127_102086_44 OsmC-like protein K04063 - - 0.0000000000000000000000000000000000000000003529 165.0
TLS2_k127_102086_45 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000004167 161.0
TLS2_k127_102086_46 protein conserved in bacteria (DUF2179) - - - 0.000000000000000000000000000000000000000007349 160.0
TLS2_k127_102086_47 PRC-barrel domain - - - 0.00000000000000000000000000000000001 138.0
TLS2_k127_102086_48 LysE type translocator - - - 0.00000000000000000000000000000000104 137.0
TLS2_k127_102086_49 Major Facilitator Superfamily - - - 0.000000000000000000000000000009428 138.0
TLS2_k127_102086_5 Dehydrogenase K00140 - 1.2.1.18,1.2.1.27 1.557e-218 688.0
TLS2_k127_102086_50 Rho termination factor, N-terminal domain - - - 0.0000000000000000000000000001939 119.0
TLS2_k127_102086_51 PAS domain - - - 0.0000000000000000000000000006232 130.0
TLS2_k127_102086_52 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000133 100.0
TLS2_k127_102086_53 CAAX protease self-immunity K07052 - - 0.000000000000000000008496 102.0
TLS2_k127_102086_54 Shikimate kinase K00891 - 2.7.1.71 0.00000000000000000004988 96.0
TLS2_k127_102086_55 - - - - 0.000000000000000001331 93.0
TLS2_k127_102086_56 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.000000000000001478 87.0
TLS2_k127_102086_57 - - - - 0.00000000000002209 80.0
TLS2_k127_102086_58 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.000000000002674 72.0
TLS2_k127_102086_59 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648,K18003 - 2.3.1.180,2.3.1.262 0.00000000000838 68.0
TLS2_k127_102086_6 Dihydropyrimidinase K01464 - 3.5.2.2 6.595e-207 652.0
TLS2_k127_102086_60 Histidine kinase K02484 - 2.7.13.3 0.00000000001348 75.0
TLS2_k127_102086_62 Histidine kinase-like ATPase domain - - - 0.0000000006524 67.0
TLS2_k127_102086_63 Protein of unknown function (DUF998) - - - 0.000000000823 71.0
TLS2_k127_102086_64 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000179 59.0
TLS2_k127_102086_66 Putative Flp pilus-assembly TadE/G-like - - - 0.000106 55.0
TLS2_k127_102086_7 GTP-binding protein TypA K06207 - - 3.845e-205 664.0
TLS2_k127_102086_8 acyl-CoA dehydrogenase K09456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 608.0
TLS2_k127_102086_9 Belongs to the glycosyl hydrolase 57 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005267 593.0
TLS2_k127_1092548_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.4.4.2 0.0 1215.0
TLS2_k127_1092548_1 belongs to the aldehyde dehydrogenase family K00130,K00151 - 1.2.1.60,1.2.1.8 5.031e-218 692.0
TLS2_k127_1092548_10 Transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005069 472.0
TLS2_k127_1092548_11 aminotransferase class I and II K00812,K10907,K14260 - 2.6.1.1,2.6.1.2,2.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 456.0
TLS2_k127_1092548_12 Fumarylacetoacetate (FAA) hydrolase family K05921 - 4.1.1.68 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 447.0
TLS2_k127_1092548_13 Oligopeptide/dipeptide transporter, C-terminal region K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 439.0
TLS2_k127_1092548_14 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009071 435.0
TLS2_k127_1092548_15 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 429.0
TLS2_k127_1092548_16 CoA-transferase family III K01796 - 5.1.99.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006242 419.0
TLS2_k127_1092548_17 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 413.0
TLS2_k127_1092548_18 Putative exonuclease SbcCD, C subunit K03546 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 426.0
TLS2_k127_1092548_19 cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 405.0
TLS2_k127_1092548_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 1.183e-216 690.0
TLS2_k127_1092548_20 protein methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 391.0
TLS2_k127_1092548_21 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 384.0
TLS2_k127_1092548_22 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 381.0
TLS2_k127_1092548_23 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 367.0
TLS2_k127_1092548_24 Acetoacetate decarboxylase (ADC) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 371.0
TLS2_k127_1092548_25 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 364.0
TLS2_k127_1092548_26 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003489 363.0
TLS2_k127_1092548_27 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 363.0
TLS2_k127_1092548_28 PFAM NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus K00057 GO:0003674,GO:0003824,GO:0006072,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 337.0
TLS2_k127_1092548_29 Right handed beta helix region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007382 349.0
TLS2_k127_1092548_3 COG0433 Predicted ATPase K06915 - - 1.51e-215 693.0
TLS2_k127_1092548_30 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 GO:0008150,GO:0040007 4.2.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 327.0
TLS2_k127_1092548_31 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 316.0
TLS2_k127_1092548_32 transferase activity, transferring glycosyl groups K18818 - 2.4.1.269 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 320.0
TLS2_k127_1092548_33 ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 312.0
TLS2_k127_1092548_34 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006582 306.0
TLS2_k127_1092548_35 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K15893 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 300.0
TLS2_k127_1092548_36 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 306.0
TLS2_k127_1092548_37 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 304.0
TLS2_k127_1092548_38 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 294.0
TLS2_k127_1092548_39 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003796 287.0
TLS2_k127_1092548_4 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 610.0
TLS2_k127_1092548_40 Beta-eliminating lyase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006041 289.0
TLS2_k127_1092548_41 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001276 286.0
TLS2_k127_1092548_42 ABC-type dipeptide oligopeptide nickel transport system, permease component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002588 285.0
TLS2_k127_1092548_43 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007749 283.0
TLS2_k127_1092548_44 Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007508 280.0
TLS2_k127_1092548_45 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004914 273.0
TLS2_k127_1092548_46 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006008 269.0
TLS2_k127_1092548_47 Peptidase dimerisation domain K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000006595 273.0
TLS2_k127_1092548_48 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003016 254.0
TLS2_k127_1092548_49 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006834 265.0
TLS2_k127_1092548_5 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005128 620.0
TLS2_k127_1092548_50 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.000000000000000000000000000000000000000000000000000000000000000000001073 240.0
TLS2_k127_1092548_51 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000003343 240.0
TLS2_k127_1092548_52 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000003934 240.0
TLS2_k127_1092548_53 Evidence 2b Function of strongly homologous gene - - - 0.00000000000000000000000000000000000000000000000000000000000000000008347 247.0
TLS2_k127_1092548_54 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001494 235.0
TLS2_k127_1092548_55 Belongs to the enoyl-CoA hydratase isomerase family K01692 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000002307 234.0
TLS2_k127_1092548_56 Belongs to the N-Me-Phe pilin family - - - 0.00000000000000000000000000000000000000000000000000000000000000001558 236.0
TLS2_k127_1092548_57 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000002201 245.0
TLS2_k127_1092548_58 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000001623 228.0
TLS2_k127_1092548_59 chorismate binding enzyme K02361,K02552 - 5.4.4.2 0.00000000000000000000000000000000000000000000000000000000000002811 228.0
TLS2_k127_1092548_6 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 527.0
TLS2_k127_1092548_60 VanW like protein - - - 0.00000000000000000000000000000000000000000000000000000000000003152 238.0
TLS2_k127_1092548_61 mechanosensitive ion channel K22044 - - 0.000000000000000000000000000000000000000000000000000000004269 208.0
TLS2_k127_1092548_62 - - - - 0.000000000000000000000000000000000000000000001312 175.0
TLS2_k127_1092548_63 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000006536 178.0
TLS2_k127_1092548_64 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000000000008467 172.0
TLS2_k127_1092548_65 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.0000000000000000000000000000000000000000001356 164.0
TLS2_k127_1092548_66 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.00000000000000000000000000000000000000003334 158.0
TLS2_k127_1092548_67 Probable molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000491 158.0
TLS2_k127_1092548_68 ABC transporter - - - 0.0000000000000000000000000000000000000001856 165.0
TLS2_k127_1092548_69 - - - - 0.000000000000000000000000000000000000000237 166.0
TLS2_k127_1092548_7 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 522.0
TLS2_k127_1092548_70 transcriptional regulator - - - 0.0000000000000000000000000000000000005386 145.0
TLS2_k127_1092548_71 NifU-like domain K07400 - - 0.00000000000000000000000000000000003237 150.0
TLS2_k127_1092548_72 ABC transporter - - - 0.00000000000000000000000000000000909 145.0
TLS2_k127_1092548_73 EamA-like transporter family - - - 0.00000000000000000000000000000009631 134.0
TLS2_k127_1092548_74 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000005313 122.0
TLS2_k127_1092548_76 Putative inner membrane exporter, YdcZ K09936 - - 0.0000000000000000000000000001738 119.0
TLS2_k127_1092548_77 Histidine kinase K07654 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.0000000000000000000000003282 122.0
TLS2_k127_1092548_78 PBP superfamily domain K05772 - - 0.000000000000000000000001311 113.0
TLS2_k127_1092548_79 PhoQ Sensor - - - 0.000000000000000000000004566 118.0
TLS2_k127_1092548_8 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 487.0
TLS2_k127_1092548_80 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000418 106.0
TLS2_k127_1092548_81 PFAM Diacylglycerol kinase, catalytic - - - 0.000000000000000000005111 104.0
TLS2_k127_1092548_82 Thiamin pyrophosphokinase, vitamin B1 binding domain K00949 - 2.7.6.2 0.00000000000000000001267 99.0
TLS2_k127_1092548_83 SnoaL-like domain - - - 0.00000000000000000009419 89.0
TLS2_k127_1092548_84 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 0.000000000000000004399 89.0
TLS2_k127_1092548_85 blue (type 1) copper K00368 - 1.7.2.1 0.00000000003089 70.0
TLS2_k127_1092548_86 PFAM Cytochrome C - - - 0.00000001821 61.0
TLS2_k127_1092548_87 RecB family exonuclease K07465 - - 0.00000005104 63.0
TLS2_k127_1092548_9 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 476.0
TLS2_k127_1097322_0 DNA polymerase alpha chain like domain K02337 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 0.0 1206.0
TLS2_k127_1097322_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 3.95e-321 1025.0
TLS2_k127_1097322_10 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 374.0
TLS2_k127_1097322_11 associated with various cellular activities K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008404 364.0
TLS2_k127_1097322_12 abc transporter atp-binding protein K05847 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 357.0
TLS2_k127_1097322_13 PFAM Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003096 352.0
TLS2_k127_1097322_14 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 346.0
TLS2_k127_1097322_15 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0008150,GO:0040007 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003212 336.0
TLS2_k127_1097322_16 COGs COG0534 Na -driven multidrug efflux pump K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 319.0
TLS2_k127_1097322_17 Penicillin-binding protein dimerisation domain K03587,K08384 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 321.0
TLS2_k127_1097322_18 aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000803 298.0
TLS2_k127_1097322_19 short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001159 282.0
TLS2_k127_1097322_2 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 596.0
TLS2_k127_1097322_20 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005231 285.0
TLS2_k127_1097322_21 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000003331 273.0
TLS2_k127_1097322_22 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003595 258.0
TLS2_k127_1097322_23 Evidence 2b Function of strongly homologous gene - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000142 261.0
TLS2_k127_1097322_24 Substrate binding domain of ABC-type glycine betaine transport system K05845 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001767 254.0
TLS2_k127_1097322_25 Mur ligase middle domain K01925 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000001051 261.0
TLS2_k127_1097322_26 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000003952 246.0
TLS2_k127_1097322_27 Binding-protein-dependent transport system inner membrane component K05846 - - 0.000000000000000000000000000000000000000000000000000000000000001171 230.0
TLS2_k127_1097322_28 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000001708 227.0
TLS2_k127_1097322_29 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000003877 219.0
TLS2_k127_1097322_3 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006129 567.0
TLS2_k127_1097322_30 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000008679 212.0
TLS2_k127_1097322_31 Thioesterase - - - 0.0000000000000000000000000000000000000000000000000000000008947 210.0
TLS2_k127_1097322_32 cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000139 221.0
TLS2_k127_1097322_33 Binding-protein-dependent transport system inner membrane component K05846 - - 0.0000000000000000000000000000000000000000000000000000001924 208.0
TLS2_k127_1097322_34 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000003786 199.0
TLS2_k127_1097322_35 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000000000000005562 200.0
TLS2_k127_1097322_36 Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000004031 204.0
TLS2_k127_1097322_37 endonuclease - - - 0.00000000000000000000000000000000000000000000000000009836 190.0
TLS2_k127_1097322_38 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000003947 194.0
TLS2_k127_1097322_39 Cytochrome C biogenesis protein K06196,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000003259 185.0
TLS2_k127_1097322_4 PFAM Aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007804 468.0
TLS2_k127_1097322_40 Rhomboid family K19225 - 3.4.21.105 0.000000000000000000000000000000000000000000000002313 183.0
TLS2_k127_1097322_41 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000001704 189.0
TLS2_k127_1097322_42 AAA domain - - - 0.00000000000000000000000000000000000000000000003342 181.0
TLS2_k127_1097322_43 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000004835 179.0
TLS2_k127_1097322_44 anion-transporting ATPase - - - 0.000000000000000000000000000000000000000000001586 181.0
TLS2_k127_1097322_45 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000003139 172.0
TLS2_k127_1097322_46 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000000000008323 184.0
TLS2_k127_1097322_47 Prolyl oligopeptidase family K06889 - - 0.0000000000000000000000000000000000000000004896 169.0
TLS2_k127_1097322_48 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02193,K02194 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 0.0000000000000000000000000000000000000002576 160.0
TLS2_k127_1097322_49 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000000000003712 164.0
TLS2_k127_1097322_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007931 459.0
TLS2_k127_1097322_50 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000006289 120.0
TLS2_k127_1097322_51 MraZ protein, putative antitoxin-like K03925 - - 0.0000000000000000000000003532 109.0
TLS2_k127_1097322_52 Belongs to the GcvT family K06980 - - 0.000000000000000000000000507 120.0
TLS2_k127_1097322_53 phosphoglycerate mutase - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000534 113.0
TLS2_k127_1097322_54 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000005375 107.0
TLS2_k127_1097322_55 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000007824 110.0
TLS2_k127_1097322_56 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.00000000000000000000004802 105.0
TLS2_k127_1097322_57 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.4.23.36 0.0000000000000000000001787 103.0
TLS2_k127_1097322_58 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944 - 0.000000000000000000004057 103.0
TLS2_k127_1097322_59 Protein of unknown function (DUF1232) - - - 0.000000000000000000008431 97.0
TLS2_k127_1097322_6 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 448.0
TLS2_k127_1097322_60 subunit of a heme lyase - - - 0.0000000000000000000504 100.0
TLS2_k127_1097322_61 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA K09772 - - 0.000000000000000006879 91.0
TLS2_k127_1097322_62 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000006792 84.0
TLS2_k127_1097322_63 Belongs to the UPF0235 family K09131 - - 0.0000000000000001257 82.0
TLS2_k127_1097322_64 Major facilitator superfamily - - - 0.000000000000007904 87.0
TLS2_k127_1097322_65 - - - - 0.00000000000001382 75.0
TLS2_k127_1097322_66 Transcriptional regulator, TraR DksA family K06204 - - 0.0000000000001139 76.0
TLS2_k127_1097322_67 DivIVA domain protein K04074 - - 0.00000000000192 78.0
TLS2_k127_1097322_68 - - - - 0.0000000009938 63.0
TLS2_k127_1097322_69 Cell division protein FtsQ K03589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - 0.00000001209 65.0
TLS2_k127_1097322_7 GIY-YIG type nucleases (URI domain) K02342 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003473 434.0
TLS2_k127_1097322_70 YGGT family K02221 - - 0.0000001494 56.0
TLS2_k127_1097322_71 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.00001236 56.0
TLS2_k127_1097322_72 metallopeptidase activity K16922 - - 0.00002815 56.0
TLS2_k127_1097322_73 snoRNA binding - - - 0.00003588 48.0
TLS2_k127_1097322_74 Protein of unknown function (DUF3040) - - - 0.00004023 50.0
TLS2_k127_1097322_75 Essential cell division protein - - - 0.0003154 51.0
TLS2_k127_1097322_8 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006043 391.0
TLS2_k127_1097322_9 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 381.0
TLS2_k127_1170129_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 2.702e-210 670.0
TLS2_k127_1170129_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004788 393.0
TLS2_k127_1170129_2 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 - 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 322.0
TLS2_k127_1170129_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 303.0
TLS2_k127_1170129_4 Trehalose utilisation K09992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002018 289.0
TLS2_k127_1170129_5 Displays ATPase and GTPase activities K06958 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001037 278.0
TLS2_k127_1170129_6 Required for morphogenesis under gluconeogenic growth conditions - - - 0.0000000000000000000000000000000000000000000000000000135 203.0
TLS2_k127_1170129_7 GDP-mannose 4,6 dehydratase K01710 - 4.2.1.46 0.0000000000000000000005744 96.0
TLS2_k127_1170129_8 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000005222 101.0
TLS2_k127_1170129_9 Preprotein translocase SecG subunit K03075 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000001141 81.0
TLS2_k127_1174535_0 Hemerythrin HHE cation binding domain K01534 - 3.6.3.3,3.6.3.5 4.59e-220 706.0
TLS2_k127_1174535_1 TIGRFAM FeS assembly protein SufB K09014 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - 1.43e-200 628.0
TLS2_k127_1174535_10 Branched-chain amino acid transport system / permease component K02057,K10440,K17209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005891 323.0
TLS2_k127_1174535_11 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 300.0
TLS2_k127_1174535_12 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004645 296.0
TLS2_k127_1174535_13 Periplasmic binding protein-like domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001332 261.0
TLS2_k127_1174535_14 COG1129 ABC-type sugar transport system, ATPase component K02056,K10441,K10545 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000002081 251.0
TLS2_k127_1174535_15 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003287 245.0
TLS2_k127_1174535_16 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000000004738 244.0
TLS2_k127_1174535_17 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000004292 241.0
TLS2_k127_1174535_18 SIS domain K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000001024 238.0
TLS2_k127_1174535_19 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000002091 223.0
TLS2_k127_1174535_20 F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000122 212.0
TLS2_k127_1174535_21 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000000000000000000000002649 205.0
TLS2_k127_1174535_22 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.000000000000000000000000000000000000000000000000000001686 197.0
TLS2_k127_1174535_23 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000006284 200.0
TLS2_k127_1174535_24 purine nucleotide biosynthetic process K02529 - - 0.000000000000000000000000000000000000000000000000001712 198.0
TLS2_k127_1174535_25 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.00000000000000000000000000000000000000000000000005946 189.0
TLS2_k127_1174535_26 COGs COG1853 Conserved protein domain typically associated with flavoprotein oxygenase DIM6 NTAB family - - - 0.0000000000000000000000000000000000000000000000007459 183.0
TLS2_k127_1174535_27 metal-dependent membrane protease - - - 0.00000000000000000000000000000000001415 146.0
TLS2_k127_1174535_28 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase K01185,K02395,K19223 - 3.2.1.17 0.00000000000000000000000000000005996 139.0
TLS2_k127_1174535_29 Peptidase family M23 K21472 - - 0.0000000000000000000944 102.0
TLS2_k127_1174535_3 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 484.0
TLS2_k127_1174535_30 Clp amino terminal domain, pathogenicity island component - - - 0.0000000000000000003192 95.0
TLS2_k127_1174535_31 - - - - 0.0000000000000001664 80.0
TLS2_k127_1174535_32 Belongs to the UPF0337 (CsbD) family - - - 0.0000000001797 64.0
TLS2_k127_1174535_33 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.000003571 52.0
TLS2_k127_1174535_34 - - - - 0.00009613 48.0
TLS2_k127_1174535_4 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 457.0
TLS2_k127_1174535_5 Iron-containing alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 364.0
TLS2_k127_1174535_6 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 360.0
TLS2_k127_1174535_7 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 347.0
TLS2_k127_1174535_8 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 330.0
TLS2_k127_1174535_9 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 329.0
TLS2_k127_1366950_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 2.488e-238 760.0
TLS2_k127_1366950_1 K+ potassium transporter K03549 - - 5.11e-217 690.0
TLS2_k127_1366950_10 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005749 352.0
TLS2_k127_1366950_11 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 327.0
TLS2_k127_1366950_12 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 304.0
TLS2_k127_1366950_13 Belongs to the dCTP deaminase family K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000244 269.0
TLS2_k127_1366950_14 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003555 274.0
TLS2_k127_1366950_15 Putative undecaprenyl diphosphate synthase K00806,K12503 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.0000000000000000000000000000000000000000000000000000000000000000000000000782 256.0
TLS2_k127_1366950_16 SdpI/YhfL protein family - - - 0.0000000000000000000000000000000000000000000000000000000000005014 219.0
TLS2_k127_1366950_17 alpha-ribazole phosphatase activity K01834,K02226,K15634,K22305 - 3.1.3.3,3.1.3.73,5.4.2.11,5.4.2.12 0.0000000000000000000000000000000000000000000000000001681 194.0
TLS2_k127_1366950_18 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000003062 188.0
TLS2_k127_1366950_19 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000005598 169.0
TLS2_k127_1366950_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007242 561.0
TLS2_k127_1366950_20 Single-strand binding protein family K03111 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000002237 163.0
TLS2_k127_1366950_21 PFAM Endonuclease Exonuclease phosphatase - - - 0.0000000000000000000000000000000000000000004557 169.0
TLS2_k127_1366950_22 ECF sigma factor K03088 GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000003305 162.0
TLS2_k127_1366950_23 - - - - 0.000000000000000000000000000000000001699 151.0
TLS2_k127_1366950_24 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.000000000000000000000000000000001382 140.0
TLS2_k127_1366950_25 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000116 129.0
TLS2_k127_1366950_26 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000006746 131.0
TLS2_k127_1366950_27 Domain of unknown function (DU1801) - - - 0.00000000000000000000000003018 112.0
TLS2_k127_1366950_28 Transcriptional regulator, ArsR family - - - 0.00000000000000000000002997 102.0
TLS2_k127_1366950_29 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000673 101.0
TLS2_k127_1366950_3 tRNA nucleotidyltransferase poly(A) polymerase K00970,K00974 - 2.7.7.19,2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 470.0
TLS2_k127_1366950_30 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000109 104.0
TLS2_k127_1366950_31 serine threonine protein kinase - - - 0.0000000000000000004091 100.0
TLS2_k127_1366950_32 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000002437 79.0
TLS2_k127_1366950_33 FR47-like protein - - - 0.00000000000007004 85.0
TLS2_k127_1366950_34 - - - - 0.000001045 55.0
TLS2_k127_1366950_35 alpha beta - - - 0.0008446 50.0
TLS2_k127_1366950_4 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 423.0
TLS2_k127_1366950_5 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 432.0
TLS2_k127_1366950_6 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008073 425.0
TLS2_k127_1366950_7 MFS_1 like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005297 398.0
TLS2_k127_1366950_8 argininosuccinate lyase activity K01755,K14681 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 400.0
TLS2_k127_1366950_9 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 372.0
TLS2_k127_1367735_0 Penicillin amidase K01434 - 3.5.1.11 6.779e-251 800.0
TLS2_k127_1367735_1 4Fe-4S dicluster domain - - - 5.024e-241 766.0
TLS2_k127_1367735_10 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 533.0
TLS2_k127_1367735_100 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.00000000000000000000000000007044 123.0
TLS2_k127_1367735_101 Ferredoxin K02230 - 6.6.1.2 0.000000000000000000000000000128 120.0
TLS2_k127_1367735_102 Domain of unknown function (DUF4332) - - - 0.0000000000000000000000000003962 117.0
TLS2_k127_1367735_103 Peptidase family M50 - - - 0.000000000000000000000000001419 123.0
TLS2_k127_1367735_104 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000007941 115.0
TLS2_k127_1367735_105 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000289 108.0
TLS2_k127_1367735_106 PFAM Bacterial regulatory proteins, gntR family K07979 - - 0.00000000000000000000000387 105.0
TLS2_k127_1367735_107 translation release factor activity - - - 0.0000000000000000000001564 110.0
TLS2_k127_1367735_108 Anti-sigma-K factor rskA - - - 0.0000000000000000000004433 104.0
TLS2_k127_1367735_109 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000006759 108.0
TLS2_k127_1367735_11 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007541 537.0
TLS2_k127_1367735_110 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000005135 105.0
TLS2_k127_1367735_111 Protein of unknown function (DUF4230) - - - 0.000000000000000002152 96.0
TLS2_k127_1367735_112 Protein of unknown function (DUF2905) - - - 0.000000000000001496 78.0
TLS2_k127_1367735_113 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000206 79.0
TLS2_k127_1367735_114 Peptidase family M23 K21472 - - 0.000000000000007367 87.0
TLS2_k127_1367735_115 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000008463 85.0
TLS2_k127_1367735_116 Protein of unknown function (DUF454) K09790 - - 0.00000000000003429 78.0
TLS2_k127_1367735_117 thioesterase K07107 - - 0.000000000000121 76.0
TLS2_k127_1367735_118 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000296 77.0
TLS2_k127_1367735_119 SnoaL-like domain - - - 0.000000000004343 73.0
TLS2_k127_1367735_12 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009607 526.0
TLS2_k127_1367735_120 Bacterial regulatory proteins, tetR family - - - 0.00000000001218 75.0
TLS2_k127_1367735_121 - - - - 0.00000000006415 70.0
TLS2_k127_1367735_122 - - - - 0.000000001934 67.0
TLS2_k127_1367735_123 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - - 0.000000002791 70.0
TLS2_k127_1367735_124 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.0000002019 62.0
TLS2_k127_1367735_125 Belongs to the peptidase S8 family - - - 0.0000006896 62.0
TLS2_k127_1367735_126 Phage integrase family - - - 0.000003172 49.0
TLS2_k127_1367735_127 Domain of unknown function (DUF4388) - - - 0.00001816 55.0
TLS2_k127_1367735_128 - - - - 0.0000644 49.0
TLS2_k127_1367735_13 PFAM Aminotransferase class I and II K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 492.0
TLS2_k127_1367735_14 Sulfate transporter K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 501.0
TLS2_k127_1367735_15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006806 481.0
TLS2_k127_1367735_16 Belongs to the thiolase family K00626,K02615 - 2.3.1.174,2.3.1.223,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 480.0
TLS2_k127_1367735_17 PFAM oxidoreductase molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004012 482.0
TLS2_k127_1367735_18 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 472.0
TLS2_k127_1367735_19 pfkB family carbohydrate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005106 462.0
TLS2_k127_1367735_2 Molybdopterin oxidoreductase Fe4S4 domain - - - 3.375e-225 716.0
TLS2_k127_1367735_20 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 445.0
TLS2_k127_1367735_21 ABC-type Fe3 transport system permease component K02011,K02063 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006152 443.0
TLS2_k127_1367735_22 fructose-bisphosphate aldolase, class II, yeast E. coli subtype K01624 GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 438.0
TLS2_k127_1367735_23 COG0189 Glutathione synthase Ribosomal protein S6 modification - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 422.0
TLS2_k127_1367735_24 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004888 428.0
TLS2_k127_1367735_25 PFAM Cys Met metabolism pyridoxal-phosphate- dependent protein K01739,K01758,K01761 - 2.5.1.48,4.4.1.1,4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003669 426.0
TLS2_k127_1367735_26 Branched-chain amino acid transport system / permease component K10440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 401.0
TLS2_k127_1367735_27 F420-dependent oxidoreductase, MSMEG_2906 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 390.0
TLS2_k127_1367735_28 saccharopine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 393.0
TLS2_k127_1367735_29 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 378.0
TLS2_k127_1367735_3 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - - 9.446e-219 699.0
TLS2_k127_1367735_30 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 376.0
TLS2_k127_1367735_31 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 372.0
TLS2_k127_1367735_32 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 368.0
TLS2_k127_1367735_33 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004047 386.0
TLS2_k127_1367735_34 phosphogluconate dehydrogenase (decarboxylating) activity K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 355.0
TLS2_k127_1367735_35 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 347.0
TLS2_k127_1367735_36 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007441 344.0
TLS2_k127_1367735_37 PFAM Short-chain dehydrogenase reductase SDR K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 340.0
TLS2_k127_1367735_38 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005502 339.0
TLS2_k127_1367735_39 ABC-type sugar transport system periplasmic component K02058,K10439 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 335.0
TLS2_k127_1367735_4 Biotin carboxylase K01968 - 6.4.1.4 2.885e-210 672.0
TLS2_k127_1367735_40 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 329.0
TLS2_k127_1367735_41 ABC transporter, periplasmic binding protein, thiB subfamily K02064 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 321.0
TLS2_k127_1367735_42 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009213 319.0
TLS2_k127_1367735_43 Peptidase family M20/M25/M40 K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 316.0
TLS2_k127_1367735_44 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 314.0
TLS2_k127_1367735_45 Amidohydrolase K07046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 306.0
TLS2_k127_1367735_46 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000436 304.0
TLS2_k127_1367735_47 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 299.0
TLS2_k127_1367735_48 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004041 283.0
TLS2_k127_1367735_49 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures K07503 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004646 296.0
TLS2_k127_1367735_5 carboxylic acid catabolic process K18334 - 4.2.1.68 1.214e-202 638.0
TLS2_k127_1367735_50 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008773 276.0
TLS2_k127_1367735_51 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009288 282.0
TLS2_k127_1367735_52 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009833 268.0
TLS2_k127_1367735_53 Domain of unknown function (DUF4872) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001169 273.0
TLS2_k127_1367735_54 YibE/F-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002143 271.0
TLS2_k127_1367735_55 PFAM L-carnitine dehydratase bile acid-inducible protein F K18702 - 2.8.3.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000003029 271.0
TLS2_k127_1367735_56 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005828 273.0
TLS2_k127_1367735_57 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001437 268.0
TLS2_k127_1367735_58 TIGRFAM DNA polymerase LigD, polymerase domain protein K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000205 267.0
TLS2_k127_1367735_59 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007846 251.0
TLS2_k127_1367735_6 COG1960 Acyl-CoA dehydrogenases K20035 - - 3.649e-196 631.0
TLS2_k127_1367735_60 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000002672 250.0
TLS2_k127_1367735_61 ABC transporter K02010,K02052,K02062 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000497 254.0
TLS2_k127_1367735_62 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000007362 241.0
TLS2_k127_1367735_63 Rhodanese-related sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000001475 234.0
TLS2_k127_1367735_64 PFAM Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000002806 238.0
TLS2_k127_1367735_65 KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000000000000000000000000000000000002242 228.0
TLS2_k127_1367735_66 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000004809 224.0
TLS2_k127_1367735_67 gntR family K05799 - - 0.00000000000000000000000000000000000000000000000000000000000004964 223.0
TLS2_k127_1367735_68 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000003251 218.0
TLS2_k127_1367735_69 PFAM Clp amino terminal domain - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000003126 213.0
TLS2_k127_1367735_7 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02827 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.10.3.12,1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 609.0
TLS2_k127_1367735_70 helix_turn_helix isocitrate lyase regulation - - - 0.00000000000000000000000000000000000000000000000000000000009215 213.0
TLS2_k127_1367735_71 Cytochrome c oxidase subunit III K02276,K02299 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000001055 211.0
TLS2_k127_1367735_72 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000003479 210.0
TLS2_k127_1367735_73 Sir2 family K12410 - - 0.0000000000000000000000000000000000000000000000000000000008276 210.0
TLS2_k127_1367735_74 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily K03216 - 2.1.1.207 0.000000000000000000000000000000000000000000000000000000009582 205.0
TLS2_k127_1367735_75 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000006127 202.0
TLS2_k127_1367735_76 VIT family - - - 0.000000000000000000000000000000000000000000000000000001057 203.0
TLS2_k127_1367735_77 Uncharacterised protein family UPF0047 - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000002133 193.0
TLS2_k127_1367735_78 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000005528 202.0
TLS2_k127_1367735_79 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000004606 188.0
TLS2_k127_1367735_8 [isocitrate dehydrogenase (NADP+)] phosphatase activity K00906 GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 559.0
TLS2_k127_1367735_80 Thioesterase-like superfamily - - - 0.000000000000000000000000000000000000000000000000005106 191.0
TLS2_k127_1367735_81 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000003379 186.0
TLS2_k127_1367735_82 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000002919 185.0
TLS2_k127_1367735_83 HhH-GPD superfamily base excision DNA repair protein - - - 0.00000000000000000000000000000000000000000000000853 179.0
TLS2_k127_1367735_84 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02862 - - 0.0000000000000000000000000000000000000000000007552 177.0
TLS2_k127_1367735_85 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000008262 186.0
TLS2_k127_1367735_86 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000002579 171.0
TLS2_k127_1367735_87 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000001814 162.0
TLS2_k127_1367735_89 TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000003475 162.0
TLS2_k127_1367735_9 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007766 571.0
TLS2_k127_1367735_90 Ribosomal protein S6 modification protein - - - 0.000000000000000000000000000000000000001954 154.0
TLS2_k127_1367735_91 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.0000000000000000000000000000000000000239 161.0
TLS2_k127_1367735_92 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000003201 133.0
TLS2_k127_1367735_93 Transcriptional regulator, MarR family - - - 0.00000000000000000000000000000001112 132.0
TLS2_k127_1367735_94 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.0000000000000000000000000000002315 127.0
TLS2_k127_1367735_95 Secreted repeat of unknown function - - - 0.000000000000000000000000000000363 129.0
TLS2_k127_1367735_96 Transcriptional regulator - - - 0.000000000000000000000000000001365 124.0
TLS2_k127_1367735_97 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000003287 133.0
TLS2_k127_1367735_98 XdhC and CoxI family K07402 - - 0.00000000000000000000000000003695 119.0
TLS2_k127_1367735_99 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.0000000000000000000000000000547 128.0
TLS2_k127_1447028_0 AMP-binding enzyme K01897 - 6.2.1.3 1.658e-234 739.0
TLS2_k127_1447028_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 495.0
TLS2_k127_1447028_10 acetylesterase activity - - - 0.0000000000000000000000000000000000000002557 173.0
TLS2_k127_1447028_11 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.0000000000000000000000000000000003443 136.0
TLS2_k127_1447028_12 transcriptional regulator - - - 0.000000000000000000000007733 106.0
TLS2_k127_1447028_13 Uncharacterized conserved protein (DUF2277) - - - 0.000000000000000002491 90.0
TLS2_k127_1447028_14 Zincin-like metallopeptidase - - - 0.00000000000000001712 94.0
TLS2_k127_1447028_16 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000594 62.0
TLS2_k127_1447028_17 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000003136 63.0
TLS2_k127_1447028_19 Recombinase - - - 0.00002812 46.0
TLS2_k127_1447028_2 OST-HTH/LOTUS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007924 420.0
TLS2_k127_1447028_3 Voltage gated chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 366.0
TLS2_k127_1447028_4 mitochondrial respiratory chain complex I assembly K18166 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000112 263.0
TLS2_k127_1447028_5 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000001242 253.0
TLS2_k127_1447028_6 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0000000000000000000000000000000000000000000000000003565 199.0
TLS2_k127_1447028_7 PFAM ornithine cyclodeaminase mu-crystallin K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000005348 186.0
TLS2_k127_1447028_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000000000000000007316 176.0
TLS2_k127_1447028_9 Protein of unknown function (DUF3494) - - - 0.0000000000000000000000000000000000000000000003024 184.0
TLS2_k127_154012_0 A circularly permuted ATPgrasp - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 526.0
TLS2_k127_154012_1 Truncated hemoglobins K06886 - - 0.000000000000000000000000000000000000000000000000000000000000000002353 231.0
TLS2_k127_154012_10 - - - - 0.0000000000102 70.0
TLS2_k127_154012_11 Histidine kinase K07679 - 2.7.13.3 0.0000000003298 73.0
TLS2_k127_154012_12 HNH endonuclease - - - 0.000000001372 65.0
TLS2_k127_154012_13 bacterial-type flagellum organization - - - 0.0000000496 64.0
TLS2_k127_154012_14 - - - - 0.0000004238 58.0
TLS2_k127_154012_15 PFAM SAF domain - - - 0.000002242 58.0
TLS2_k127_154012_16 Helix-turn-helix domain - - - 0.000009598 50.0
TLS2_k127_154012_17 PFAM TadE family protein - - - 0.0002641 50.0
TLS2_k127_154012_2 Type II/IV secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000003709 240.0
TLS2_k127_154012_3 A predicted alpha-helical domain with a conserved ER motif. - - - 0.000000000000000000000000000000000000000000000000000000000003476 219.0
TLS2_k127_154012_4 Bacterial transglutaminase-like N-terminal region - - - 0.0000000000000000000000000000000000000000000000000000003878 205.0
TLS2_k127_154012_5 Domain of unknown function (DUF4389) - - - 0.00000000000000000000000000000000000000009625 153.0
TLS2_k127_154012_6 Type II secretion system (T2SS), protein F K12510 - - 0.0000000000000000000000004869 117.0
TLS2_k127_154012_7 Protein of unknown function (DUF3048) C-terminal domain - - - 0.00000000000000000000000306 115.0
TLS2_k127_154012_8 Type II secretion system (T2SS), protein F K12511 - - 0.000000000003688 78.0
TLS2_k127_154012_9 Histidine kinase K07679 - 2.7.13.3 0.00000000000552 78.0
TLS2_k127_1892366_0 NADH flavin oxidoreductase NADH oxidase K00354,K09461 GO:0000003,GO:0000302,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006950,GO:0006979,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009620,GO:0009694,GO:0009695,GO:0009791,GO:0009908,GO:0009987,GO:0010035,GO:0010193,GO:0010817,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016629,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0042221,GO:0042445,GO:0042446,GO:0042493,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046677,GO:0048367,GO:0048437,GO:0048438,GO:0048443,GO:0048466,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0051704,GO:0051707,GO:0055114,GO:0061458,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0090567,GO:0099402,GO:1901576,GO:1901700 1.14.13.40,1.6.99.1 2.211e-289 907.0
TLS2_k127_1892366_1 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 623.0
TLS2_k127_1892366_10 May catalyze the transamination reaction in phenylalanine biosynthesis K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000103 270.0
TLS2_k127_1892366_11 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000001173 231.0
TLS2_k127_1892366_12 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000008737 226.0
TLS2_k127_1892366_13 peroxiredoxin activity K03386,K03564,K16922 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000003656 209.0
TLS2_k127_1892366_14 phosphoribosyltransferase K07100 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000001382 204.0
TLS2_k127_1892366_15 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000002542 197.0
TLS2_k127_1892366_16 Belongs to the NUDIX hydrolase family K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000001362 194.0
TLS2_k127_1892366_17 NAD(P)H-dependent FMN reductase K19784 - - 0.0000000000000000000000000000000000000000000000003026 187.0
TLS2_k127_1892366_18 transcriptional regulator - - - 0.00000000000000000000000000000000000000000009474 164.0
TLS2_k127_1892366_19 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000005352 149.0
TLS2_k127_1892366_2 ABC transporter transmembrane region K02021,K06147,K16786,K16787 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007802 484.0
TLS2_k127_1892366_20 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.00000000000000000000000000000004271 138.0
TLS2_k127_1892366_21 homoserine kinase activity - - - 0.000000000000000000000000002285 123.0
TLS2_k127_1892366_23 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.0000000000000006692 86.0
TLS2_k127_1892366_3 ABC transporter, transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 461.0
TLS2_k127_1892366_4 Pyridoxal-phosphate dependent enzyme K01697 - 4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007662 418.0
TLS2_k127_1892366_5 Alpha Beta K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 342.0
TLS2_k127_1892366_6 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 362.0
TLS2_k127_1892366_7 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 353.0
TLS2_k127_1892366_8 Patched family K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002126 304.0
TLS2_k127_1892366_9 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002583 284.0
TLS2_k127_1931793_0 DEAD/H associated K03724 - - 0.0 1416.0
TLS2_k127_1931793_1 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1264.0
TLS2_k127_1931793_10 Belongs to the malate synthase family K01638 - 2.3.3.9 1.318e-200 637.0
TLS2_k127_1931793_100 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.000000000000000000000000000000000000000000000001538 185.0
TLS2_k127_1931793_101 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 0.0000000000000000000000000000000000000000000003568 184.0
TLS2_k127_1931793_102 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000151 172.0
TLS2_k127_1931793_103 metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000000000000000000000000008476 169.0
TLS2_k127_1931793_104 Belongs to the DNA glycosylase MPG family K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.00000000000000000000000000000000000000000003627 168.0
TLS2_k127_1931793_105 Bacterial lipid A biosynthesis acyltransferase K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.0000000000000000000000000000000000000000000652 174.0
TLS2_k127_1931793_106 Lipoate-protein ligase - - - 0.0000000000000000000000000000000000000000006705 167.0
TLS2_k127_1931793_107 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000012 162.0
TLS2_k127_1931793_108 - - - - 0.0000000000000000000000000000000000000001391 156.0
TLS2_k127_1931793_109 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000000000003549 151.0
TLS2_k127_1931793_11 PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein K01740 - 2.5.1.49 3.717e-196 619.0
TLS2_k127_1931793_110 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.000000000000000000000000000000000000001263 152.0
TLS2_k127_1931793_111 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000009131 147.0
TLS2_k127_1931793_112 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.000000000000000000000000000000000001898 147.0
TLS2_k127_1931793_113 Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway K03786 GO:0003674,GO:0003824,GO:0003855,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019630,GO:0019631,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 4.2.1.10 0.000000000000000000000000000000000009926 152.0
TLS2_k127_1931793_114 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000001771 139.0
TLS2_k127_1931793_115 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000001272 131.0
TLS2_k127_1931793_116 protein conserved in bacteria - - - 0.0000000000000000000000000000007633 124.0
TLS2_k127_1931793_117 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000000000000005385 120.0
TLS2_k127_1931793_118 PFAM RNP-1 like RNA-binding protein - - - 0.0000000000000000000000000006532 114.0
TLS2_k127_1931793_119 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000003222 118.0
TLS2_k127_1931793_12 L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 582.0
TLS2_k127_1931793_120 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000004194 120.0
TLS2_k127_1931793_121 SpoU rRNA Methylase family K03437 - - 0.00000000000000000000000001633 119.0
TLS2_k127_1931793_122 alpha/beta hydrolase fold - - - 0.00000000000000000000000006617 122.0
TLS2_k127_1931793_123 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.000000000000000000000000315 111.0
TLS2_k127_1931793_124 Ferric uptake regulator family K03711 - - 0.000000000000000000000003515 107.0
TLS2_k127_1931793_125 Patatin-like phospholipase K07001 - - 0.000000000000000000000007892 113.0
TLS2_k127_1931793_126 - - - - 0.00000000000000000000001218 109.0
TLS2_k127_1931793_127 - - - - 0.00000000000000000000001516 101.0
TLS2_k127_1931793_128 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000007175 108.0
TLS2_k127_1931793_129 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000001216 107.0
TLS2_k127_1931793_13 Alcohol dehydrogenase GroES-like domain K18369 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 552.0
TLS2_k127_1931793_130 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.000000000000000000001261 111.0
TLS2_k127_1931793_131 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.000000000000000000004393 96.0
TLS2_k127_1931793_132 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 GO:0008150,GO:0040007 - 0.000000000000000000005622 101.0
TLS2_k127_1931793_133 transglycosylase associated protein - - - 0.0000000000000000006188 91.0
TLS2_k127_1931793_134 hydroperoxide reductase activity - - - 0.000000000000000001025 87.0
TLS2_k127_1931793_135 integration host factor - - - 0.000000000000000005527 87.0
TLS2_k127_1931793_136 Type IV leader peptidase family - - - 0.00000000000000001294 92.0
TLS2_k127_1931793_137 - - - - 0.00000000000000004677 87.0
TLS2_k127_1931793_138 hydroperoxide reductase activity - - - 0.00000000000000007213 83.0
TLS2_k127_1931793_139 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000001888 76.0
TLS2_k127_1931793_14 Ftsk_gamma K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 570.0
TLS2_k127_1931793_140 - - - - 0.00000000000002694 78.0
TLS2_k127_1931793_141 structural constituent of ribosome K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000002422 74.0
TLS2_k127_1931793_142 Preprotein translocase subunit K03210 - - 0.000000000003006 71.0
TLS2_k127_1931793_143 ATPase associated with various cellular activities, AAA_5 K04748 - - 0.000000004963 68.0
TLS2_k127_1931793_144 LysM domain - - - 0.00000008635 58.0
TLS2_k127_1931793_145 - - - - 0.000001807 58.0
TLS2_k127_1931793_146 - - - - 0.000002986 50.0
TLS2_k127_1931793_147 Domain of unknown function (DUF4388) - - - 0.000006992 58.0
TLS2_k127_1931793_148 Universal stress protein - - - 0.00002651 53.0
TLS2_k127_1931793_149 Phosphotransferase enzyme family - - - 0.0002845 52.0
TLS2_k127_1931793_15 Elongation factor Tu domain 2 K02355 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009279 567.0
TLS2_k127_1931793_16 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 536.0
TLS2_k127_1931793_17 Belongs to the citrate synthase family K01647 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 531.0
TLS2_k127_1931793_18 Endoribonuclease that initiates mRNA decay K18682 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005696 514.0
TLS2_k127_1931793_19 Ferredoxin-fold anticodon binding domain K01890 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 516.0
TLS2_k127_1931793_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - 1.413e-289 906.0
TLS2_k127_1931793_20 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 498.0
TLS2_k127_1931793_21 PFAM Peptidase S10, serine carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008309 488.0
TLS2_k127_1931793_22 Elongator protein 3 MiaB NifB K11779 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 490.0
TLS2_k127_1931793_23 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 470.0
TLS2_k127_1931793_24 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 464.0
TLS2_k127_1931793_25 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 445.0
TLS2_k127_1931793_26 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 439.0
TLS2_k127_1931793_27 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 433.0
TLS2_k127_1931793_28 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004752 430.0
TLS2_k127_1931793_29 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 430.0
TLS2_k127_1931793_3 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 1.048e-278 883.0
TLS2_k127_1931793_30 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 430.0
TLS2_k127_1931793_31 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004321 427.0
TLS2_k127_1931793_32 IrrE N-terminal-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009211 421.0
TLS2_k127_1931793_33 Protein of unknown function (DUF993) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008013 420.0
TLS2_k127_1931793_34 Insulinase (Peptidase family M16) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 416.0
TLS2_k127_1931793_35 Belongs to the CarA family K01955,K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 406.0
TLS2_k127_1931793_36 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 404.0
TLS2_k127_1931793_37 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 404.0
TLS2_k127_1931793_38 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 394.0
TLS2_k127_1931793_39 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 393.0
TLS2_k127_1931793_4 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 7.753e-227 731.0
TLS2_k127_1931793_40 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 385.0
TLS2_k127_1931793_41 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004039 355.0
TLS2_k127_1931793_42 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 346.0
TLS2_k127_1931793_43 tRNA synthetase class II core domain (G, H, P, S and T) K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008549 333.0
TLS2_k127_1931793_44 Branched-chain amino acid transport system permease K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 341.0
TLS2_k127_1931793_45 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 329.0
TLS2_k127_1931793_46 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 321.0
TLS2_k127_1931793_47 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 329.0
TLS2_k127_1931793_48 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005396 321.0
TLS2_k127_1931793_49 Belongs to the CinA family K03742 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 327.0
TLS2_k127_1931793_5 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 3.05e-223 715.0
TLS2_k127_1931793_50 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 322.0
TLS2_k127_1931793_51 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008501 315.0
TLS2_k127_1931793_52 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 314.0
TLS2_k127_1931793_53 Cupin superfamily protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 311.0
TLS2_k127_1931793_54 ABC 3 transport family K02075,K09819 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 305.0
TLS2_k127_1931793_55 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008703 298.0
TLS2_k127_1931793_56 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 297.0
TLS2_k127_1931793_57 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 296.0
TLS2_k127_1931793_58 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 289.0
TLS2_k127_1931793_59 branched-chain amino acid transmembrane transporter activity K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001259 287.0
TLS2_k127_1931793_6 PFAM ABC transporter transmembrane region K06147 - - 4.126e-217 691.0
TLS2_k127_1931793_60 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003453 282.0
TLS2_k127_1931793_61 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001038 282.0
TLS2_k127_1931793_62 Amino acid amide ABC transporter, ATP-binding protein, 1, HAAT family K01995,K11957 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001065 282.0
TLS2_k127_1931793_63 Alkyl hydroperoxide reductase and or thiol-specific antioxidant family (AhpC TSA) protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005744 268.0
TLS2_k127_1931793_64 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004279 274.0
TLS2_k127_1931793_65 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005699 264.0
TLS2_k127_1931793_66 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000002628 262.0
TLS2_k127_1931793_67 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000002868 268.0
TLS2_k127_1931793_68 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000001971 255.0
TLS2_k127_1931793_69 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000002422 258.0
TLS2_k127_1931793_7 Isocitrate lyase K01637 - 4.1.3.1 4.833e-209 656.0
TLS2_k127_1931793_70 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000001827 254.0
TLS2_k127_1931793_71 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000002013 252.0
TLS2_k127_1931793_72 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000005908 239.0
TLS2_k127_1931793_73 Putative glycosyl hydrolase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001993 248.0
TLS2_k127_1931793_74 PFAM Ribulose-phosphate 3-epimerase K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000001274 238.0
TLS2_k127_1931793_75 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000002385 242.0
TLS2_k127_1931793_76 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.00000000000000000000000000000000000000000000000000000000000000006541 233.0
TLS2_k127_1931793_77 PFAM short chain dehydrogenase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000006899 228.0
TLS2_k127_1931793_78 Periplasmic binding protein LacI transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000196 231.0
TLS2_k127_1931793_79 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000002101 228.0
TLS2_k127_1931793_8 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 5.591e-208 664.0
TLS2_k127_1931793_80 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000000003825 221.0
TLS2_k127_1931793_81 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000005153 218.0
TLS2_k127_1931793_82 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000005882 222.0
TLS2_k127_1931793_83 Glycosyltransferase K08256 GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 0.000000000000000000000000000000000000000000000000000000000001951 224.0
TLS2_k127_1931793_85 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) - - - 0.00000000000000000000000000000000000000000000000000000000008211 218.0
TLS2_k127_1931793_86 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000001633 205.0
TLS2_k127_1931793_87 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K00226,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 0.000000000000000000000000000000000000000000000000000000003166 219.0
TLS2_k127_1931793_88 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000002239 198.0
TLS2_k127_1931793_89 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768,K12132 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.11.1,5.2.1.8 0.0000000000000000000000000000000000000000000000000000003019 199.0
TLS2_k127_1931793_9 ketone body catabolic process K01026 - 2.8.3.1 1.634e-203 652.0
TLS2_k127_1931793_90 riboflavin synthase, alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.0000000000000000000000000000000000000000000000000000005095 203.0
TLS2_k127_1931793_91 Sucrase/ferredoxin-like - - - 0.000000000000000000000000000000000000000000000000000003879 203.0
TLS2_k127_1931793_92 Belongs to the UPF0173 family - - - 0.000000000000000000000000000000000000000000000000000004983 198.0
TLS2_k127_1931793_93 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.0000000000000000000000000000000000000000000000000000102 196.0
TLS2_k127_1931793_94 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.00000000000000000000000000000000000000000000000000008067 194.0
TLS2_k127_1931793_95 CoA binding domain K06929 - - 0.000000000000000000000000000000000000000000000000001143 192.0
TLS2_k127_1931793_96 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000002085 190.0
TLS2_k127_1931793_97 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000003475 193.0
TLS2_k127_1931793_98 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000005636 194.0
TLS2_k127_1931793_99 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.0000000000000000000000000000000000000000000000000981 183.0
TLS2_k127_1947640_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 6.15e-212 668.0
TLS2_k127_1947640_1 3-deoxy-7-phosphoheptulonate synthase activity K00661,K03856,K04092,K04093,K04516,K04518,K14170,K14187 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,2.3.1.79,2.5.1.54,4.2.1.51,5.4.99.5 9.997e-209 668.0
TLS2_k127_1947640_2 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 439.0
TLS2_k127_1947640_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000001589 222.0
TLS2_k127_1947640_4 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000001968 84.0
TLS2_k127_1947640_5 - - - - 0.00002568 49.0
TLS2_k127_1952627_0 SMART Adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000005382 120.0
TLS2_k127_1952627_1 Rieske [2Fe-2S] domain - - - 0.0000000000000000000008722 109.0
TLS2_k127_1952627_3 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000002194 72.0
TLS2_k127_1975189_0 Glutamine synthetase, beta-Grasp domain K01915 GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 7.261e-232 729.0
TLS2_k127_1975189_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 527.0
TLS2_k127_1975189_2 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009914 387.0
TLS2_k127_1975189_3 acetyltransferase involved in intracellular survival - - - 0.000000000000000000000000000000000000000000000000000000000000000000001421 253.0
TLS2_k127_1975189_4 2OG-Fe(II) oxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000002176 204.0
TLS2_k127_1975189_5 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000002484 174.0
TLS2_k127_1975189_6 CorA-like Mg2+ transporter protein K03284 - - 0.00000000000000000000000000000395 133.0
TLS2_k127_203015_0 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003286 457.0
TLS2_k127_203015_1 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 436.0
TLS2_k127_203015_2 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006947 270.0
TLS2_k127_203015_3 InterPro IPR014922 - - - 0.0000000000000000000000000000000000000000000000001102 182.0
TLS2_k127_203015_4 - - - - 0.00000000000000000000000000000000000000000000000435 175.0
TLS2_k127_203015_5 Trypsin-like serine protease - - - 0.000000000000000000000000000000000000001787 161.0
TLS2_k127_2065269_0 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 461.0
TLS2_k127_2065269_1 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000342 462.0
TLS2_k127_2065269_10 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 336.0
TLS2_k127_2065269_11 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 328.0
TLS2_k127_2065269_12 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 316.0
TLS2_k127_2065269_13 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 309.0
TLS2_k127_2065269_14 May function as heme-dependent peroxidase K00435 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005625 291.0
TLS2_k127_2065269_15 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K14080 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.246,4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002142 287.0
TLS2_k127_2065269_16 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000749 263.0
TLS2_k127_2065269_17 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002219 267.0
TLS2_k127_2065269_18 PFAM PHP domain K07053,K20859 - 3.1.3.97,3.1.4.57 0.00000000000000000000000000000000000000000000000000000000000000000000904 243.0
TLS2_k127_2065269_19 Domain of unknown function (DUF3291) - - - 0.00000000000000000000000000000000000000000000000000000000000003184 232.0
TLS2_k127_2065269_2 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008883 425.0
TLS2_k127_2065269_20 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000001708 216.0
TLS2_k127_2065269_21 phosphatase activity K05967 - - 0.0000000000000000000000000000000000000000000000000000000003686 207.0
TLS2_k127_2065269_22 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000001749 213.0
TLS2_k127_2065269_23 Abc-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000006459 198.0
TLS2_k127_2065269_24 PFAM Haloacid dehalogenase domain protein hydrolase - - - 0.00000000000000000000000000000000000000000000000001173 188.0
TLS2_k127_2065269_25 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000002304 191.0
TLS2_k127_2065269_26 Abc-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000001758 187.0
TLS2_k127_2065269_27 organic phosphonate transmembrane transporter activity K02042 - - 0.00000000000000000000000000000000000000000000001794 193.0
TLS2_k127_2065269_28 Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.0000000000000000000000000000000000001873 145.0
TLS2_k127_2065269_29 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.0000000000000000000000000000000001039 143.0
TLS2_k127_2065269_3 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 418.0
TLS2_k127_2065269_30 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000001537 141.0
TLS2_k127_2065269_31 - K01992 - - 0.00000000000000000000000000004826 134.0
TLS2_k127_2065269_32 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000001155 100.0
TLS2_k127_2065269_33 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000004968 106.0
TLS2_k127_2065269_34 - - - - 0.00000000000000000001182 103.0
TLS2_k127_2065269_35 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000001573 72.0
TLS2_k127_2065269_36 transcriptional regulator - - - 0.00000003053 63.0
TLS2_k127_2065269_37 synthase K01719 - 4.2.1.75 0.0001815 51.0
TLS2_k127_2065269_4 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 389.0
TLS2_k127_2065269_5 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007596 376.0
TLS2_k127_2065269_6 fructose-1,6-bisphosphatase K02446 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 378.0
TLS2_k127_2065269_7 ATPase associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 371.0
TLS2_k127_2065269_8 SMART Metal-dependent phosphohydrolase, HD region K01129 - 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 364.0
TLS2_k127_2065269_9 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006455 332.0
TLS2_k127_208919_0 Belongs to the peptidase S8 family - - - 1e-323 1019.0
TLS2_k127_208919_1 Belongs to the peptidase S8 family - - - 1.414e-279 891.0
TLS2_k127_208919_10 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006332 368.0
TLS2_k127_208919_11 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 349.0
TLS2_k127_208919_12 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 332.0
TLS2_k127_208919_13 galactosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 334.0
TLS2_k127_208919_14 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 321.0
TLS2_k127_208919_15 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000565 314.0
TLS2_k127_208919_16 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 290.0
TLS2_k127_208919_17 Metallopeptidase family M24 K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000264 275.0
TLS2_k127_208919_18 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008333 278.0
TLS2_k127_208919_19 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003023 273.0
TLS2_k127_208919_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 9.266e-236 739.0
TLS2_k127_208919_20 Bacterial sugar transferase K13012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006096 271.0
TLS2_k127_208919_21 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008171 263.0
TLS2_k127_208919_22 Forms part of the polypeptide exit tunnel K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000002538 244.0
TLS2_k127_208919_23 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000003296 239.0
TLS2_k127_208919_24 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000009253 226.0
TLS2_k127_208919_25 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000001543 229.0
TLS2_k127_208919_26 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000329 226.0
TLS2_k127_208919_27 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000001175 223.0
TLS2_k127_208919_28 PFAM peptidase S58 DmpA - - - 0.000000000000000000000000000000000000000000000000000000000000002473 228.0
TLS2_k127_208919_29 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000001499 226.0
TLS2_k127_208919_3 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 6.765e-201 644.0
TLS2_k127_208919_30 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000002921 232.0
TLS2_k127_208919_31 Uracil-DNA glycosylase, family 4 K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000004277 226.0
TLS2_k127_208919_32 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000004529 208.0
TLS2_k127_208919_33 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000001861 212.0
TLS2_k127_208919_34 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000000000000000000000001496 206.0
TLS2_k127_208919_35 PFAM Glycosyl transferase, group 1 K19424 - - 0.0000000000000000000000000000000000000000000000000000001069 209.0
TLS2_k127_208919_36 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000002023 188.0
TLS2_k127_208919_37 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000002323 184.0
TLS2_k127_208919_38 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000002894 186.0
TLS2_k127_208919_39 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000000000000006062 177.0
TLS2_k127_208919_4 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 434.0
TLS2_k127_208919_40 COG0451 Nucleoside-diphosphate-sugar epimerases K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000003981 178.0
TLS2_k127_208919_41 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000246 166.0
TLS2_k127_208919_42 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000001742 171.0
TLS2_k127_208919_43 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000003637 166.0
TLS2_k127_208919_44 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000001158 163.0
TLS2_k127_208919_45 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000000000000002102 159.0
TLS2_k127_208919_46 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000009727 163.0
TLS2_k127_208919_47 - - - - 0.000000000000000000000000000000000000001259 168.0
TLS2_k127_208919_48 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000001008 153.0
TLS2_k127_208919_49 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000131 147.0
TLS2_k127_208919_5 DegT/DnrJ/EryC1/StrS aminotransferase family K13010,K19430 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005148 435.0
TLS2_k127_208919_50 Glycoprotease family K14742 GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000254 151.0
TLS2_k127_208919_51 Formyl transferase K00604 - 2.1.2.9 0.000000000000000000000000000000000002748 151.0
TLS2_k127_208919_52 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000001638 142.0
TLS2_k127_208919_53 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000003683 135.0
TLS2_k127_208919_54 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000005207 140.0
TLS2_k127_208919_55 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000000000000000000000000865 136.0
TLS2_k127_208919_56 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000002514 127.0
TLS2_k127_208919_57 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000108 120.0
TLS2_k127_208919_58 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000001798 117.0
TLS2_k127_208919_59 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 GO:0008150,GO:0040007 - 0.0000000000000000000000000005564 120.0
TLS2_k127_208919_6 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009394 430.0
TLS2_k127_208919_60 Protein of unknown function (DUF559) - - - 0.0000000000000000000000003056 119.0
TLS2_k127_208919_61 Glycosyl transferases group 1 K00754 - - 0.000000000000000000000002883 115.0
TLS2_k127_208919_62 Glycosyl transferase 4-like - - - 0.00000000000000000000008929 111.0
TLS2_k127_208919_63 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000153 100.0
TLS2_k127_208919_64 - - - - 0.0000000000000000000002581 107.0
TLS2_k127_208919_65 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000003163 100.0
TLS2_k127_208919_66 Pfam:DUF385 - - - 0.0000000000000000000006033 101.0
TLS2_k127_208919_67 translation elongation factor activity K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000002523 84.0
TLS2_k127_208919_68 Ribosomal L29 protein K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000009718 85.0
TLS2_k127_208919_69 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000007679 76.0
TLS2_k127_208919_7 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 404.0
TLS2_k127_208919_70 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000000128 73.0
TLS2_k127_208919_71 Ribosomal protein L30p/L7e K02907 - - 0.00000000001714 68.0
TLS2_k127_208919_72 Capsular exopolysaccharide family - - - 0.00001498 59.0
TLS2_k127_208919_8 Pantothenic acid kinase K00867 GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 375.0
TLS2_k127_208919_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005696 361.0
TLS2_k127_2225691_0 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 559.0
TLS2_k127_2225691_1 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 394.0
TLS2_k127_2225691_2 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009241 307.0
TLS2_k127_2225691_3 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 301.0
TLS2_k127_2225691_4 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007309 273.0
TLS2_k127_2225691_5 Protein of unknown function (DUF664) - - - 0.00000000000000000000000003149 112.0
TLS2_k127_2225691_6 Domain of unknown function (DUF4389) - - - 0.000000000000000000006351 92.0
TLS2_k127_2225691_7 Serine aminopeptidase, S33 - - - 0.0000000000004053 75.0
TLS2_k127_2225691_8 Phospholipid methyltransferase - - - 0.0000000003898 68.0
TLS2_k127_2225691_9 Protein of unknown function (DUF664) - - - 0.00000001339 56.0
TLS2_k127_2301464_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 475.0
TLS2_k127_2301464_1 beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 435.0
TLS2_k127_2301464_10 Bacterial periplasmic substrate-binding proteins K02030,K10005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004521 353.0
TLS2_k127_2301464_11 ABC transporter K02028,K09972 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005865 357.0
TLS2_k127_2301464_12 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 356.0
TLS2_k127_2301464_13 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 348.0
TLS2_k127_2301464_14 PFAM Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 313.0
TLS2_k127_2301464_15 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 316.0
TLS2_k127_2301464_16 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000462 264.0
TLS2_k127_2301464_17 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000001222 266.0
TLS2_k127_2301464_18 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004399 262.0
TLS2_k127_2301464_19 Binding-protein-dependent transport system inner membrane component K09970 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002439 264.0
TLS2_k127_2301464_2 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 428.0
TLS2_k127_2301464_20 TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family K09971 - - 0.000000000000000000000000000000000000000000000000000000000000000000001169 264.0
TLS2_k127_2301464_21 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000003872 233.0
TLS2_k127_2301464_22 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000003288 227.0
TLS2_k127_2301464_23 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000443 193.0
TLS2_k127_2301464_24 enzyme of poly-gamma-glutamate biosynthesis (Capsule formation) K07282 - - 0.0000000000000000000000000000000000000000000000376 184.0
TLS2_k127_2301464_25 Belongs to the TrpC family K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.0000000000000000000000000000000000000000006915 168.0
TLS2_k127_2301464_26 ABC transporter K02029,K02030 - - 0.000000000000000000000000000000000000004845 148.0
TLS2_k127_2301464_27 PFAM transcriptional regulator PadR family protein K10947 - - 0.000000000000000000000000000000004959 132.0
TLS2_k127_2301464_28 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.00000000000000000000000000000004893 133.0
TLS2_k127_2301464_29 helix_turn_helix, mercury resistance K13640 - - 0.0000000000000000000000000005915 117.0
TLS2_k127_2301464_3 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K09972,K10041 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 412.0
TLS2_k127_2301464_30 - - - - 0.0000000000000001515 91.0
TLS2_k127_2301464_31 NfeD-like C-terminal, partner-binding - - - 0.000000000002621 76.0
TLS2_k127_2301464_32 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000001306 66.0
TLS2_k127_2301464_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 395.0
TLS2_k127_2301464_5 stress-induced mitochondrial fusion - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005424 384.0
TLS2_k127_2301464_6 amino acid ABC transporter, ATP-binding protein K02028,K17076 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 368.0
TLS2_k127_2301464_7 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008064 376.0
TLS2_k127_2301464_8 Binding-protein-dependent transport system inner membrane component K02029 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008985 355.0
TLS2_k127_2301464_9 Pfam Amidohydrolase K20810 - 3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009171 376.0
TLS2_k127_2407880_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004139 520.0
TLS2_k127_2407880_1 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001733 300.0
TLS2_k127_2407880_10 - - - - 0.0000000000000000000007448 98.0
TLS2_k127_2407880_11 - - - - 0.000005097 59.0
TLS2_k127_2407880_2 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001198 269.0
TLS2_k127_2407880_3 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002881 259.0
TLS2_k127_2407880_4 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01190 - 3.2.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000003785 260.0
TLS2_k127_2407880_5 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000002751 211.0
TLS2_k127_2407880_6 Domain of unknown function (DUF5060) - - - 0.00000000000000000000000000000000000000000000000000005803 210.0
TLS2_k127_2407880_7 Ketosteroid isomerase-related protein - - - 0.000000000000000000000000000000000000000000673 162.0
TLS2_k127_2407880_8 GCN5-related N-acetyl-transferase K06975 - - 0.000000000000000000000001012 106.0
TLS2_k127_2407880_9 alpha/beta hydrolase fold - - - 0.00000000000000000000001067 111.0
TLS2_k127_2501638_0 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 430.0
TLS2_k127_2501638_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000002529 212.0
TLS2_k127_2501638_2 EAL domain-containing protein - - - 0.0000000000000000000000000000000000000000141 172.0
TLS2_k127_2501638_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000151 146.0
TLS2_k127_2501638_4 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000002258 138.0
TLS2_k127_2501638_5 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000003646 117.0
TLS2_k127_2501638_6 DNA-binding transcription factor activity - - - 0.000000000000000000000003424 105.0
TLS2_k127_2501638_7 Activator of Hsp90 ATPase - - - 0.000000000000000001456 91.0
TLS2_k127_2501638_8 Sensory domain in DIguanylate Cyclases and Two-component system - - - 0.000001448 59.0
TLS2_k127_2546982_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005266 489.0
TLS2_k127_2546982_1 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 460.0
TLS2_k127_2546982_10 Protein of unknown function (DUF983) - - - 0.00000000000000000000000000738 114.0
TLS2_k127_2546982_11 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000001846 104.0
TLS2_k127_2546982_2 Catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000849 276.0
TLS2_k127_2546982_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000004042 267.0
TLS2_k127_2546982_4 Pfam:PNPOx_C K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000001823 230.0
TLS2_k127_2546982_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000007371 190.0
TLS2_k127_2546982_6 Beta-lactamase superfamily domain - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 - 0.0000000000000000000000000000000000000000000003487 178.0
TLS2_k127_2546982_7 Transcriptional regulator K13652 - - 0.00000000000000000000000000000000000495 142.0
TLS2_k127_2546982_8 pterin-4-alpha-carbinolamine dehydratase - - - 0.00000000000000000000000000001132 120.0
TLS2_k127_2546982_9 ferredoxin K05337 - - 0.000000000000000000000000001891 114.0
TLS2_k127_27123_0 arsenical-resistance protein K03325,K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009437 514.0
TLS2_k127_27123_1 synthase K00697,K16055 GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 462.0
TLS2_k127_27123_10 Glycosyl hydrolases family 15 K01087 - 3.1.3.12 0.0000000000000000000000000000000000004659 154.0
TLS2_k127_27123_11 PFAM NIF3 (NGG1p interacting factor 3) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000002155 141.0
TLS2_k127_27123_12 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K03469 - 3.1.26.4 0.00000000000000000005347 96.0
TLS2_k127_27123_13 membrane-bound metal-dependent hydrolase - - - 0.0000000000000000002549 94.0
TLS2_k127_27123_14 C4-type zinc ribbon domain K07164 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000289 85.0
TLS2_k127_27123_16 photosynthesis K12132,K20543 - 2.7.11.1 0.00001996 51.0
TLS2_k127_27123_17 AIG2-like family K00682 GO:0001836,GO:0002376,GO:0003674,GO:0003824,GO:0003839,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0007599,GO:0008150,GO:0008152,GO:0008219,GO:0008637,GO:0009058,GO:0009611,GO:0009987,GO:0012501,GO:0016043,GO:0016829,GO:0016840,GO:0016842,GO:0019184,GO:0023052,GO:0032501,GO:0034641,GO:0042060,GO:0042381,GO:0042398,GO:0042802,GO:0042803,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0045087,GO:0046983,GO:0050789,GO:0050794,GO:0050817,GO:0050878,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0097190,GO:1901564,GO:1901566,GO:1901576 4.3.2.9 0.00002357 53.0
TLS2_k127_27123_2 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 351.0
TLS2_k127_27123_3 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002883 289.0
TLS2_k127_27123_4 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001744 290.0
TLS2_k127_27123_5 Chlorophyllase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006695 266.0
TLS2_k127_27123_6 SOS response associated peptidase (SRAP) - - - 0.00000000000000000000000000000000000000000000000000000001656 204.0
TLS2_k127_27123_7 cell redox homeostasis K02199 - - 0.00000000000000000000000000000000000000000000000001861 188.0
TLS2_k127_27123_8 Belongs to the MIP aquaporin (TC 1.A.8) family K02440,K06188 - - 0.0000000000000000000000000000000000000000221 162.0
TLS2_k127_27123_9 glyoxalase bleomycin resistance protein dioxygenase K07032 - - 0.00000000000000000000000000000000000000002412 161.0
TLS2_k127_2747_0 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 409.0
TLS2_k127_2747_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000002156 213.0
TLS2_k127_2747_2 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.00000000000000000000000000000000001466 141.0
TLS2_k127_2747_3 Domain of unknown function (DUF4389) - - - 0.0000000000000000482 84.0
TLS2_k127_2836892_0 xanthine dehydrogenase activity K03520 - 1.2.5.3 0.0 1440.0
TLS2_k127_2836892_1 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204 1.2.4.1 0.0 1114.0
TLS2_k127_2836892_10 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 505.0
TLS2_k127_2836892_101 Protein of unknown function (DUF541) K09807 - - 0.0000000000000000000003276 106.0
TLS2_k127_2836892_102 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.0000000000000000001818 95.0
TLS2_k127_2836892_103 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.00000000000000000751 92.0
TLS2_k127_2836892_104 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000003471 82.0
TLS2_k127_2836892_105 acr, cog1399 K07040 - - 0.00000000000000008499 87.0
TLS2_k127_2836892_106 enzyme binding K00567,K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 0.0000000000000002453 83.0
TLS2_k127_2836892_107 - - - - 0.0000000000000002976 81.0
TLS2_k127_2836892_108 Ribosomal L28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000004267 82.0
TLS2_k127_2836892_109 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000001847 85.0
TLS2_k127_2836892_11 NAT, N-acetyltransferase, of N-acetylglutamate synthase K22478 - 2.3.1.1,2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 483.0
TLS2_k127_2836892_110 bacterial-type flagellum assembly K02401,K13820 - - 0.000000000000007036 85.0
TLS2_k127_2836892_113 - - - - 0.000000000005782 73.0
TLS2_k127_2836892_114 Belongs to the UPF0102 family K07460 - - 0.0000000003943 68.0
TLS2_k127_2836892_115 Belongs to the UPF0109 family K06960 - - 0.0000000009625 63.0
TLS2_k127_2836892_117 methyltransferase activity K00587 - 2.1.1.100 0.000000005493 68.0
TLS2_k127_2836892_118 Aminoglycoside phosphotransferase - - - 0.000000007071 57.0
TLS2_k127_2836892_119 Cold shock K03704 - - 0.00000001109 63.0
TLS2_k127_2836892_12 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 483.0
TLS2_k127_2836892_120 - - - - 0.00000005879 59.0
TLS2_k127_2836892_13 Belongs to the ATCase OTCase family K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 466.0
TLS2_k127_2836892_14 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00756,K00758 - 2.4.2.2,2.4.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 457.0
TLS2_k127_2836892_15 VWA domain containing CoxE-like protein K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 452.0
TLS2_k127_2836892_16 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003858 442.0
TLS2_k127_2836892_17 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 439.0
TLS2_k127_2836892_18 Belongs to the cysteine synthase cystathionine beta- synthase family K01738,K17216 - 2.5.1.134,2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 444.0
TLS2_k127_2836892_19 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 438.0
TLS2_k127_2836892_2 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 1.593e-289 916.0
TLS2_k127_2836892_20 Belongs to the GPAT DAPAT family K00631 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003793 446.0
TLS2_k127_2836892_21 ATPase with chaperone activity K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 426.0
TLS2_k127_2836892_22 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006649 417.0
TLS2_k127_2836892_23 N,N-dimethylaniline monooxygenase activity K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 403.0
TLS2_k127_2836892_24 Dehydrogenase K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000786 391.0
TLS2_k127_2836892_25 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 398.0
TLS2_k127_2836892_26 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006178 389.0
TLS2_k127_2836892_27 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008696 381.0
TLS2_k127_2836892_28 sulfurtransferase K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 374.0
TLS2_k127_2836892_29 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 362.0
TLS2_k127_2836892_3 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003464 617.0
TLS2_k127_2836892_30 metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004371 371.0
TLS2_k127_2836892_31 AAA domain (dynein-related subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 350.0
TLS2_k127_2836892_32 Belongs to the helicase family. UvrD subfamily K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 372.0
TLS2_k127_2836892_33 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 348.0
TLS2_k127_2836892_34 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008295 347.0
TLS2_k127_2836892_35 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 336.0
TLS2_k127_2836892_36 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 338.0
TLS2_k127_2836892_37 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 337.0
TLS2_k127_2836892_38 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 325.0
TLS2_k127_2836892_39 carboxymuconolactone decarboxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 317.0
TLS2_k127_2836892_4 RecF/RecN/SMC N terminal domain K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003462 621.0
TLS2_k127_2836892_40 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 332.0
TLS2_k127_2836892_41 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 327.0
TLS2_k127_2836892_42 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 306.0
TLS2_k127_2836892_43 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007279 299.0
TLS2_k127_2836892_44 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007091 302.0
TLS2_k127_2836892_45 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 299.0
TLS2_k127_2836892_46 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008321 297.0
TLS2_k127_2836892_47 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K02405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001713 284.0
TLS2_k127_2836892_48 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007726 282.0
TLS2_k127_2836892_49 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004063 276.0
TLS2_k127_2836892_5 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 585.0
TLS2_k127_2836892_50 ABC-type multidrug transport system, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001894 290.0
TLS2_k127_2836892_51 ABC-type multidrug transport system, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004392 269.0
TLS2_k127_2836892_52 Electron transfer flavoprotein domain K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009234 256.0
TLS2_k127_2836892_53 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003609 253.0
TLS2_k127_2836892_54 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001712 251.0
TLS2_k127_2836892_55 SMART von Willebrand factor, type A K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004571 257.0
TLS2_k127_2836892_56 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000008274 256.0
TLS2_k127_2836892_57 Belongs to the RNA methyltransferase TrmD family K00554,K01770 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000001381 231.0
TLS2_k127_2836892_58 Mazg nucleotide pyrophosphohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000004272 228.0
TLS2_k127_2836892_59 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.0000000000000000000000000000000000000000000000000000000000000001917 226.0
TLS2_k127_2836892_6 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 532.0
TLS2_k127_2836892_60 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000006717 225.0
TLS2_k127_2836892_61 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000002381 225.0
TLS2_k127_2836892_62 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000000009401 220.0
TLS2_k127_2836892_63 MafB19-like deaminase - - - 0.0000000000000000000000000000000000000000000000000000000000007616 215.0
TLS2_k127_2836892_64 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 GO:0003674,GO:0003824,GO:0004845,GO:0004849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016763,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000002015 214.0
TLS2_k127_2836892_65 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000008046 212.0
TLS2_k127_2836892_66 Protein of unknown function (DUF2800) K07465 - - 0.0000000000000000000000000000000000000000000000000000000001985 214.0
TLS2_k127_2836892_67 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000003342 206.0
TLS2_k127_2836892_68 TIGRFAM DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000001168 205.0
TLS2_k127_2836892_69 - - - - 0.0000000000000000000000000000000000000000000000000000001809 198.0
TLS2_k127_2836892_7 Exporter of polyketide antibiotics K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 530.0
TLS2_k127_2836892_70 PFAM peptidase M50 K11749 GO:0008150,GO:0040007 - 0.000000000000000000000000000000000000000000000000000004409 204.0
TLS2_k127_2836892_71 carboxylic ester hydrolase activity K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000001003 198.0
TLS2_k127_2836892_72 XdhC and CoxI family K07402 - - 0.00000000000000000000000000000000000000000000000000002554 199.0
TLS2_k127_2836892_73 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000001313 196.0
TLS2_k127_2836892_74 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000000000000000000000000007529 190.0
TLS2_k127_2836892_75 PFAM Cell envelope-related transcriptional attenuator - - - 0.000000000000000000000000000000000000000000000001455 190.0
TLS2_k127_2836892_76 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000006148 183.0
TLS2_k127_2836892_77 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.00000000000000000000000000000000000000000000006937 173.0
TLS2_k127_2836892_78 Ribosomal protein L19 K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000000000001564 164.0
TLS2_k127_2836892_79 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000000006038 167.0
TLS2_k127_2836892_8 Belongs to the Glu Leu Phe Val dehydrogenases family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006044 511.0
TLS2_k127_2836892_80 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000008311 171.0
TLS2_k127_2836892_81 - - - - 0.00000000000000000000000000000000000000000487 163.0
TLS2_k127_2836892_82 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000009536 158.0
TLS2_k127_2836892_83 Histidine kinase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000446 166.0
TLS2_k127_2836892_84 Protein of unknown function (DUF2469) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000003228 145.0
TLS2_k127_2836892_85 XdhC Rossmann domain K07402 - - 0.000000000000000000000000000000000001887 149.0
TLS2_k127_2836892_86 Bacterial PH domain - - - 0.000000000000000000000000000000000003416 144.0
TLS2_k127_2836892_87 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000005483 139.0
TLS2_k127_2836892_88 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000006981 134.0
TLS2_k127_2836892_89 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000002479 138.0
TLS2_k127_2836892_9 Fatty-acid--CoA ligase K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 512.0
TLS2_k127_2836892_90 XdhC and CoxI family - - - 0.0000000000000000000000000000002828 126.0
TLS2_k127_2836892_91 - - - - 0.0000000000000000000000000000003138 128.0
TLS2_k127_2836892_92 - - - - 0.00000000000000000000000000003489 118.0
TLS2_k127_2836892_93 - - - - 0.00000000000000000000000000003695 119.0
TLS2_k127_2836892_94 AsnC family - - - 0.0000000000000000000000000005107 116.0
TLS2_k127_2836892_95 - - - - 0.000000000000000000000000002173 118.0
TLS2_k127_2836892_96 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.00000000000000000000000003786 112.0
TLS2_k127_2836892_97 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000000001574 111.0
TLS2_k127_2836892_98 - K03641 - - 0.000000000000000000000004267 117.0
TLS2_k127_2836892_99 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000008724 104.0
TLS2_k127_2867147_0 Adenylyl cyclase class-3 4 guanylyl cyclase - - - 1.312e-212 703.0
TLS2_k127_2867147_1 Serine aminopeptidase, S33 K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 352.0
TLS2_k127_2940106_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01585 - 4.1.1.19 0.0 1090.0
TLS2_k127_2940106_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 3.013e-278 863.0
TLS2_k127_2940106_10 PrpF protein K16514 - 5.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 441.0
TLS2_k127_2940106_11 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005184 437.0
TLS2_k127_2940106_12 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 395.0
TLS2_k127_2940106_13 amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 370.0
TLS2_k127_2940106_14 PaaX-like protein K02616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 340.0
TLS2_k127_2940106_15 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 349.0
TLS2_k127_2940106_16 GlcNAc-PI de-N-acetylase K16515 - 4.2.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 312.0
TLS2_k127_2940106_17 protocatechuate 3,4-dioxygenase, beta subunit' K00449 - 1.13.11.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001149 275.0
TLS2_k127_2940106_18 acid phosphatase activity K03651 - 3.1.4.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009389 278.0
TLS2_k127_2940106_19 Aldolase/RraA K02553,K10218 - 4.1.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000001039 263.0
TLS2_k127_2940106_2 (ABC) transporter K06147,K06148 - - 1.798e-272 850.0
TLS2_k127_2940106_20 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000129 254.0
TLS2_k127_2940106_21 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000004604 262.0
TLS2_k127_2940106_22 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000003064 233.0
TLS2_k127_2940106_23 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000002219 229.0
TLS2_k127_2940106_24 Adenylosuccinate lyase C-terminus K01857 - 5.5.1.2 0.000000000000000000000000000000000000000000000000000000000000005636 235.0
TLS2_k127_2940106_25 PFAM ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000004676 216.0
TLS2_k127_2940106_26 Alpha beta hydrolase K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000000000007625 217.0
TLS2_k127_2940106_27 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000001554 211.0
TLS2_k127_2940106_28 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000002478 200.0
TLS2_k127_2940106_29 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000001159 191.0
TLS2_k127_2940106_3 Aminomethyltransferase folate-binding domain K15066 - 2.1.1.341 7.394e-218 684.0
TLS2_k127_2940106_30 protocatechuate 3,4-dioxygenase K00448 - 1.13.11.3 0.0000000000000000000000000000000000000000000004541 178.0
TLS2_k127_2940106_31 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000003379 177.0
TLS2_k127_2940106_32 transport system permease K01998 - - 0.000000000000000000000000000000000000000009714 168.0
TLS2_k127_2940106_33 Alpha beta hydrolase K01055,K14727 - 3.1.1.24,4.1.1.44 0.0000000000000000000000000000000000000001975 153.0
TLS2_k127_2940106_34 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000006081 164.0
TLS2_k127_2940106_35 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000002907 119.0
TLS2_k127_2940106_36 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000001557 104.0
TLS2_k127_2940106_37 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.0000000000000000000005671 111.0
TLS2_k127_2940106_38 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000002212 102.0
TLS2_k127_2940106_39 Belongs to the glycosyl hydrolase 43 family - - - 0.00000000002359 68.0
TLS2_k127_2940106_4 Aminomethyltransferase folate-binding domain K15064 - - 2.116e-211 668.0
TLS2_k127_2940106_5 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005583 574.0
TLS2_k127_2940106_6 Domain of unknown function (DUF2088) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 551.0
TLS2_k127_2940106_7 4-hydroxybenzoate K00481 - 1.14.13.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003471 479.0
TLS2_k127_2940106_8 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004855 481.0
TLS2_k127_2940106_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K00446 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 441.0
TLS2_k127_2945284_0 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004265 362.0
TLS2_k127_2945284_1 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000277 135.0
TLS2_k127_3000816_0 FGGY family of carbohydrate kinases, N-terminal domain K00854 - 2.7.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008202 419.0
TLS2_k127_3001289_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1283.0
TLS2_k127_3001289_1 FAD dependent oxidoreductase central domain - - - 0.0 1178.0
TLS2_k127_3001289_10 Belongs to the aldehyde dehydrogenase family K00128,K00130,K00146,K10217 - 1.2.1.3,1.2.1.32,1.2.1.39,1.2.1.8,1.2.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 546.0
TLS2_k127_3001289_100 DNA recombination protein RmuC K09760 - - 0.00000000000000000000000000000000001204 149.0
TLS2_k127_3001289_101 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000002043 147.0
TLS2_k127_3001289_102 RDD family - - - 0.0000000000000000000000000000000006162 140.0
TLS2_k127_3001289_103 - - - - 0.000000000000000000000000000000002661 136.0
TLS2_k127_3001289_104 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000003239 141.0
TLS2_k127_3001289_105 peptidoglycan-binding domain-containing protein - - - 0.00000000000000000000000000000005511 138.0
TLS2_k127_3001289_106 EamA-like transporter family - - - 0.0000000000000000000000000000006134 134.0
TLS2_k127_3001289_107 lactoylglutathione lyase activity - - - 0.000000000000000000000000000002161 124.0
TLS2_k127_3001289_108 flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000004588 131.0
TLS2_k127_3001289_109 Putative stress-induced transcription regulator - - - 0.0000000000000000000000000000591 124.0
TLS2_k127_3001289_11 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006949 524.0
TLS2_k127_3001289_110 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000001566 132.0
TLS2_k127_3001289_111 His Kinase A (phosphoacceptor) domain K07654 - 2.7.13.3 0.00000000000000000000000001295 122.0
TLS2_k127_3001289_112 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000005325 111.0
TLS2_k127_3001289_113 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000002683 121.0
TLS2_k127_3001289_114 dienelactone hydrolase - - - 0.0000000000000000000000006325 113.0
TLS2_k127_3001289_115 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000008017 119.0
TLS2_k127_3001289_116 - - - - 0.00000000000000000000000216 114.0
TLS2_k127_3001289_117 - - - - 0.0000000000000000000000119 107.0
TLS2_k127_3001289_118 Endoribonuclease L-PSP - - - 0.00000000000000000000001569 105.0
TLS2_k127_3001289_119 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.0000000000000000000001637 105.0
TLS2_k127_3001289_12 CoA binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004469 530.0
TLS2_k127_3001289_120 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000004285 102.0
TLS2_k127_3001289_121 Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000009996 107.0
TLS2_k127_3001289_122 C-terminal four TMM region of protein-O-mannosyltransferase - - - 0.000000000000000000001248 104.0
TLS2_k127_3001289_124 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000001635 102.0
TLS2_k127_3001289_125 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000001154 97.0
TLS2_k127_3001289_126 - - - - 0.00000000000000000001907 96.0
TLS2_k127_3001289_127 COG3030 Protein affecting phage T7 exclusion by the F plasmid K07113 - - 0.00000000000000000002708 96.0
TLS2_k127_3001289_128 Putative cyclase - - - 0.00000000000000000006768 102.0
TLS2_k127_3001289_129 BetI-type transcriptional repressor, C-terminal - - - 0.0000000000000000003915 96.0
TLS2_k127_3001289_13 PFAM FAD dependent oxidoreductase K00301 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004931 507.0
TLS2_k127_3001289_130 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000168 86.0
TLS2_k127_3001289_131 Tail protein - - - 0.0000000000000002306 89.0
TLS2_k127_3001289_132 Cysteine-rich secretory protein family - - - 0.000000000000001873 89.0
TLS2_k127_3001289_133 - - - - 0.000000000000001889 83.0
TLS2_k127_3001289_134 Protein of unknown function (DUF2630) - - - 0.000000000000002582 82.0
TLS2_k127_3001289_136 Cell wall-associated - - - 0.00000000000001536 88.0
TLS2_k127_3001289_137 Domain of unknown function (DUF4131) K02238 - - 0.00000000000002224 84.0
TLS2_k127_3001289_138 Acetyltransferase (GNAT) domain - - - 0.0000000000001347 81.0
TLS2_k127_3001289_139 Acetyltransferase (GNAT) domain - - - 0.000000000001436 79.0
TLS2_k127_3001289_14 PFAM FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 501.0
TLS2_k127_3001289_140 D-alanyl-D-alanine carboxypeptidase - - - 0.0000000000068 79.0
TLS2_k127_3001289_141 COG0346 Lactoylglutathione lyase and related lyases - - - 0.00000000005042 70.0
TLS2_k127_3001289_142 SnoaL-like domain K06893 - - 0.00000000005144 68.0
TLS2_k127_3001289_143 - - - - 0.0000000001265 70.0
TLS2_k127_3001289_144 Domain of unknown function (DUF1992) - - - 0.0000000003651 68.0
TLS2_k127_3001289_145 Acyltransferase family - - - 0.0000000005406 66.0
TLS2_k127_3001289_146 - - - - 0.000000001124 63.0
TLS2_k127_3001289_147 Protein of unknown function (DUF559) - - - 0.000000001514 69.0
TLS2_k127_3001289_148 amine dehydrogenase activity - - - 0.000000003057 69.0
TLS2_k127_3001289_149 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000004224 66.0
TLS2_k127_3001289_15 Oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006714 505.0
TLS2_k127_3001289_150 Protein of unknown function (DUF1761) - - - 0.00000001074 62.0
TLS2_k127_3001289_151 Immunoglobulin-like domain of bacterial spore germination - - - 0.00000001349 67.0
TLS2_k127_3001289_152 s53 subtilisin kexin sedolisin - - - 0.0000001215 64.0
TLS2_k127_3001289_153 - - - - 0.0000002429 64.0
TLS2_k127_3001289_154 Domain of unknown function (DUF4129) - - - 0.0000006421 59.0
TLS2_k127_3001289_155 Baseplate J-like protein - - - 0.000006552 54.0
TLS2_k127_3001289_156 Endonuclease/Exonuclease/phosphatase family - - - 0.00001142 55.0
TLS2_k127_3001289_158 Cupin domain K00971,K08641,K11312,K19547 - 2.7.7.13,3.4.13.22,5.3.3.19 0.00003576 52.0
TLS2_k127_3001289_159 Divergent 4Fe-4S mono-cluster K05337 - - 0.0001065 48.0
TLS2_k127_3001289_16 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000768 495.0
TLS2_k127_3001289_160 Acetyltransferase (GNAT) domain - - - 0.000488 48.0
TLS2_k127_3001289_17 COG1960 Acyl-CoA dehydrogenases K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 488.0
TLS2_k127_3001289_18 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 501.0
TLS2_k127_3001289_19 Glycine cleavage T-protein C-terminal barrel domain K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 474.0
TLS2_k127_3001289_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.827e-269 849.0
TLS2_k127_3001289_20 Phage tail sheath protein K06907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 462.0
TLS2_k127_3001289_21 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 473.0
TLS2_k127_3001289_22 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 439.0
TLS2_k127_3001289_23 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 428.0
TLS2_k127_3001289_24 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00479 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005491 415.0
TLS2_k127_3001289_25 secondary active sulfate transmembrane transporter activity K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 432.0
TLS2_k127_3001289_26 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 445.0
TLS2_k127_3001289_27 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 416.0
TLS2_k127_3001289_28 Peptidase S15 K06978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 422.0
TLS2_k127_3001289_29 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 399.0
TLS2_k127_3001289_3 Flavin containing amine oxidoreductase - - - 3.573e-251 784.0
TLS2_k127_3001289_30 Aminotransferase class I and II K11358 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008153 405.0
TLS2_k127_3001289_31 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 393.0
TLS2_k127_3001289_32 DNA ligase D DNA polymerase LigD K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008756 395.0
TLS2_k127_3001289_33 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 386.0
TLS2_k127_3001289_34 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009991 385.0
TLS2_k127_3001289_35 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 389.0
TLS2_k127_3001289_36 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 394.0
TLS2_k127_3001289_37 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004694 378.0
TLS2_k127_3001289_38 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007001 379.0
TLS2_k127_3001289_39 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 369.0
TLS2_k127_3001289_4 E1-E2 ATPase K12952 - - 3.119e-234 750.0
TLS2_k127_3001289_40 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 348.0
TLS2_k127_3001289_41 F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009227 347.0
TLS2_k127_3001289_42 Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 342.0
TLS2_k127_3001289_43 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 350.0
TLS2_k127_3001289_44 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000458 349.0
TLS2_k127_3001289_45 Putrescine transport system permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 327.0
TLS2_k127_3001289_46 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 327.0
TLS2_k127_3001289_47 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 325.0
TLS2_k127_3001289_48 Bacterial extracellular solute-binding protein K11069 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 323.0
TLS2_k127_3001289_49 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 317.0
TLS2_k127_3001289_5 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 3.016e-225 722.0
TLS2_k127_3001289_50 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 323.0
TLS2_k127_3001289_51 COG1177 ABC-type spermidine putrescine transport system, permease component II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005922 314.0
TLS2_k127_3001289_52 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006084 301.0
TLS2_k127_3001289_53 Acetyltransferase (GNAT) domain K00663,K03790 - 2.3.1.128,2.3.1.82 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 298.0
TLS2_k127_3001289_54 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 290.0
TLS2_k127_3001289_55 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009085 294.0
TLS2_k127_3001289_56 Transcriptional regulator K02624 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003213 283.0
TLS2_k127_3001289_57 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003599 293.0
TLS2_k127_3001289_58 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004988 287.0
TLS2_k127_3001289_59 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006287 291.0
TLS2_k127_3001289_6 endonuclease exonuclease phosphatase K07004 - - 1.604e-220 726.0
TLS2_k127_3001289_60 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007868 278.0
TLS2_k127_3001289_61 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001094 282.0
TLS2_k127_3001289_62 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001321 277.0
TLS2_k127_3001289_63 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001939 274.0
TLS2_k127_3001289_64 Alcohol dehydrogenase GroES-like domain K00004 - 1.1.1.303,1.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000002284 265.0
TLS2_k127_3001289_65 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000001514 251.0
TLS2_k127_3001289_66 Putative serine esterase (DUF676) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002701 258.0
TLS2_k127_3001289_67 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000000000000000000000000003227 241.0
TLS2_k127_3001289_68 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000008347 261.0
TLS2_k127_3001289_69 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000005185 229.0
TLS2_k127_3001289_7 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 581.0
TLS2_k127_3001289_70 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000001458 225.0
TLS2_k127_3001289_71 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000001586 223.0
TLS2_k127_3001289_72 SMP-30/Gluconolaconase/LRE-like region K14274 - - 0.0000000000000000000000000000000000000000000000000000000000003903 222.0
TLS2_k127_3001289_73 - - - - 0.00000000000000000000000000000000000000000000000000000000001633 214.0
TLS2_k127_3001289_74 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000009048 226.0
TLS2_k127_3001289_75 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000001115 207.0
TLS2_k127_3001289_76 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000001769 224.0
TLS2_k127_3001289_77 ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000009546 211.0
TLS2_k127_3001289_78 YbaK prolyl-tRNA synthetase associated - - - 0.00000000000000000000000000000000000000000000000000000000374 203.0
TLS2_k127_3001289_79 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000005654 211.0
TLS2_k127_3001289_8 belongs to the aldehyde dehydrogenase family K21802 - 1.2.1.67 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 565.0
TLS2_k127_3001289_80 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000004904 202.0
TLS2_k127_3001289_81 glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000002989 197.0
TLS2_k127_3001289_82 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.0000000000000000000000000000000000000000000000000001042 201.0
TLS2_k127_3001289_83 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000006344 206.0
TLS2_k127_3001289_84 COG0662 Mannose-6-phosphate isomerase - - - 0.000000000000000000000000000000000000000000000000001623 192.0
TLS2_k127_3001289_85 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000003505 185.0
TLS2_k127_3001289_86 Cro/C1-type HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000004003 188.0
TLS2_k127_3001289_87 Bacterial low temperature requirement A protein (LtrA) - - - 0.0000000000000000000000000000000000000000000000003224 190.0
TLS2_k127_3001289_88 ADP binding K08282,K13419 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.11.1 0.0000000000000000000000000000000000000000000004203 184.0
TLS2_k127_3001289_89 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000003174 171.0
TLS2_k127_3001289_9 Metallopeptidase family M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006685 557.0
TLS2_k127_3001289_90 Galactose oxidase, central domain - - - 0.00000000000000000000000000000000000000000002134 175.0
TLS2_k127_3001289_91 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000001654 181.0
TLS2_k127_3001289_92 Sigma-70 region 2 - - - 0.0000000000000000000000000000000000000000002278 172.0
TLS2_k127_3001289_93 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.000000000000000000000000000000000000000004204 163.0
TLS2_k127_3001289_94 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000000005065 162.0
TLS2_k127_3001289_95 AAA ATPase domain - - - 0.00000000000000000000000000000000000000001174 178.0
TLS2_k127_3001289_96 Methyltransferase domain - - - 0.0000000000000000000000000000000000000001517 158.0
TLS2_k127_3001289_97 transcriptional regulator - - - 0.00000000000000000000000000000000000002522 154.0
TLS2_k127_3001289_98 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000002834 147.0
TLS2_k127_3001289_99 META domain - - - 0.000000000000000000000000000000000002094 146.0
TLS2_k127_3205836_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 5.869e-302 945.0
TLS2_k127_3205836_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.179e-251 790.0
TLS2_k127_3205836_10 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000000000003879 212.0
TLS2_k127_3205836_11 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000006914 185.0
TLS2_k127_3205836_12 Helix-hairpin-helix motif K02237 - - 0.0000000000000000000000000000000004061 138.0
TLS2_k127_3205836_13 COG0285 Folylpolyglutamate synthase K00796 - 2.5.1.15 0.0000000000000000000000000000001029 135.0
TLS2_k127_3205836_14 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000001085 117.0
TLS2_k127_3205836_15 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000007244 91.0
TLS2_k127_3205836_16 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000002282 87.0
TLS2_k127_3205836_17 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000008561 79.0
TLS2_k127_3205836_18 DNA polymerase III K02340 - 2.7.7.7 0.00001523 56.0
TLS2_k127_3205836_2 ABC-type dipeptide transport system, periplasmic component K02035,K12368 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005652 585.0
TLS2_k127_3205836_3 PhoH family K06217 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000933 355.0
TLS2_k127_3205836_4 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006475 335.0
TLS2_k127_3205836_5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004713 293.0
TLS2_k127_3205836_6 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000103 291.0
TLS2_k127_3205836_7 Involved in the biosynthesis of porphyrin-containing compound - GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001118 262.0
TLS2_k127_3205836_8 ComEC Rec2-related protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001594 267.0
TLS2_k127_3205836_9 7TM receptor with intracellular metal dependent phosphohydrolase K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000008948 264.0
TLS2_k127_324490_0 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system K02056,K10441 - 3.6.3.17 1.695e-243 761.0
TLS2_k127_324490_1 Alpha amylase, catalytic domain K21350 - 2.4.1.329 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 519.0
TLS2_k127_324490_10 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002572 280.0
TLS2_k127_324490_11 B3/4 domain - - - 0.0000000000000000000000000000000000000000000000000000001727 215.0
TLS2_k127_324490_12 F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000008068 196.0
TLS2_k127_324490_13 LysE type translocator - - - 0.000000000000000000000000000000000000000000000006457 184.0
TLS2_k127_324490_14 Beta-lactamase - - - 0.0000000000000000000000000000000000000000002402 163.0
TLS2_k127_324490_15 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000002069 156.0
TLS2_k127_324490_16 Redoxin - - - 0.00000000000000000000000000000002602 134.0
TLS2_k127_324490_17 Transcriptional regulator padr family - - - 0.000000000000000000000000000002587 123.0
TLS2_k127_324490_18 STAS domain K04749 - - 0.00000000006131 71.0
TLS2_k127_324490_19 Sigma-70 region 2 K03088 - - 0.000455 49.0
TLS2_k127_324490_2 Periplasmic binding protein domain K02058,K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 494.0
TLS2_k127_324490_3 Belongs to the binding-protein-dependent transport system permease family K02057,K10440,K17209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 463.0
TLS2_k127_324490_4 Branched-chain amino acid transport system / permease component K02057,K10440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004563 459.0
TLS2_k127_324490_5 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005382 397.0
TLS2_k127_324490_6 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004386 388.0
TLS2_k127_324490_7 Cytochrome c biogenesis protein transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007128 318.0
TLS2_k127_324490_8 purine nucleotide biosynthetic process K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004398 305.0
TLS2_k127_324490_9 Alcohol dehydrogenase GroES-like domain K00004,K00008 - 1.1.1.14,1.1.1.303,1.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000017 299.0
TLS2_k127_3344465_0 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 458.0
TLS2_k127_3344465_1 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 444.0
TLS2_k127_3344465_10 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000204 245.0
TLS2_k127_3344465_11 Protein of unknown function (DUF3494) - - - 0.000000000000000000000000000000000000000000000000000000000000008502 230.0
TLS2_k127_3344465_12 LysE type translocator - - - 0.0000000000000000000000000000000000000005845 156.0
TLS2_k127_3344465_13 Domain of unknown function (DUF1905) - - - 0.0000000000000000000000000000000000005081 143.0
TLS2_k127_3344465_15 SnoaL-like domain - - - 0.00000000000000000000003776 103.0
TLS2_k127_3344465_16 Transcriptional regulator - - - 0.0000000000000000003638 98.0
TLS2_k127_3344465_17 PucR C-terminal helix-turn-helix domain - - - 0.0000000000001548 81.0
TLS2_k127_3344465_18 2TM domain - - - 0.0000000000002371 77.0
TLS2_k127_3344465_2 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 409.0
TLS2_k127_3344465_3 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007727 407.0
TLS2_k127_3344465_4 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 402.0
TLS2_k127_3344465_5 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 344.0
TLS2_k127_3344465_6 pterin-4-alpha-carbinolamine dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 299.0
TLS2_k127_3344465_7 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 285.0
TLS2_k127_3344465_8 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006635 284.0
TLS2_k127_3344465_9 GCN5 family acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007063 263.0
TLS2_k127_3468542_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 5.194e-202 666.0
TLS2_k127_3468542_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 540.0
TLS2_k127_3468542_10 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K19189 - 1.14.13.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 379.0
TLS2_k127_3468542_11 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003582 373.0
TLS2_k127_3468542_12 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 356.0
TLS2_k127_3468542_13 Threonine synthase N terminus K01733 GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007343 353.0
TLS2_k127_3468542_14 arylformamidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 341.0
TLS2_k127_3468542_15 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 331.0
TLS2_k127_3468542_16 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 331.0
TLS2_k127_3468542_17 PFAM amidohydrolase 2 K03392 - 4.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 323.0
TLS2_k127_3468542_18 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 322.0
TLS2_k127_3468542_19 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005846 311.0
TLS2_k127_3468542_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 507.0
TLS2_k127_3468542_20 3-keto-5-aminohexanoate cleavage protein K18013 - 2.3.1.247 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 311.0
TLS2_k127_3468542_21 Malate/L-lactate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 312.0
TLS2_k127_3468542_22 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K16843 - 1.1.1.310 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 306.0
TLS2_k127_3468542_23 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 299.0
TLS2_k127_3468542_24 Belongs to the HpcH HpaI aldolase family K01630,K02510 - 4.1.2.20,4.1.2.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005903 291.0
TLS2_k127_3468542_25 PFAM amidohydrolase 2 K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003296 276.0
TLS2_k127_3468542_26 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000001136 271.0
TLS2_k127_3468542_27 Metallopeptidase family M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001321 272.0
TLS2_k127_3468542_28 Psort location CytoplasmicMembrane, score 10.00 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006772 266.0
TLS2_k127_3468542_29 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000001524 244.0
TLS2_k127_3468542_3 Creatinase/Prolidase N-terminal domain K01271,K15783 - 3.4.13.9,3.5.4.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 500.0
TLS2_k127_3468542_30 Belongs to the CinA family K03742 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000004246 249.0
TLS2_k127_3468542_31 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002709 242.0
TLS2_k127_3468542_32 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000677 243.0
TLS2_k127_3468542_33 FMN-dependent dehydrogenase K11517 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000001875 246.0
TLS2_k127_3468542_34 DNA ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000005713 230.0
TLS2_k127_3468542_35 HNH nucleases - - - 0.00000000000000000000000000000000000000000000000000000000000002033 231.0
TLS2_k127_3468542_36 ABC-type sugar transport system, permease component K02026 - - 0.000000000000000000000000000000000000000000000000000000002459 217.0
TLS2_k127_3468542_37 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000002313 206.0
TLS2_k127_3468542_38 Enoyl-CoA hydratase/isomerase K01661,K07536 - 4.1.3.36 0.000000000000000000000000000000000000000000000000000002344 201.0
TLS2_k127_3468542_39 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000004117 201.0
TLS2_k127_3468542_4 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007147 467.0
TLS2_k127_3468542_40 Amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000000000000000000000000000004153 200.0
TLS2_k127_3468542_41 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000002672 198.0
TLS2_k127_3468542_42 Oxidoreductase family, C-terminal alpha/beta domain K19181 - 1.1.1.292 0.0000000000000000000000000000000000000000000000000009523 199.0
TLS2_k127_3468542_43 PFAM alpha beta hydrolase fold K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000003074 182.0
TLS2_k127_3468542_44 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000004415 177.0
TLS2_k127_3468542_45 Glucose dehydrogenase C-terminus K00001,K00344 - 1.1.1.1,1.6.5.5 0.00000000000000000000000000000000000000000000007124 185.0
TLS2_k127_3468542_46 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000007189 169.0
TLS2_k127_3468542_47 PFAM Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000002601 167.0
TLS2_k127_3468542_48 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000007973 160.0
TLS2_k127_3468542_49 Belongs to the SUA5 family K07566 GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.87 0.0000000000000000000000000000000000006349 146.0
TLS2_k127_3468542_5 Amidohydrolase family K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 456.0
TLS2_k127_3468542_50 carboxymuconolactone decarboxylase - - - 0.0000000000000000000000000000000000007996 145.0
TLS2_k127_3468542_51 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000001007 154.0
TLS2_k127_3468542_52 transcriptional regulator - - - 0.00000000000000000000000000000000001172 146.0
TLS2_k127_3468542_53 Yqey-like protein K09117 - - 0.0000000000000000000000000000001607 129.0
TLS2_k127_3468542_54 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000001312 120.0
TLS2_k127_3468542_55 Binds the 23S rRNA K02909 - - 0.0000000000000000000000000001024 117.0
TLS2_k127_3468542_56 Glycerophosphodiester phosphodiesterase family protein K01126 - 3.1.4.46 0.000000000000000000000002283 111.0
TLS2_k127_3468542_57 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000005108 105.0
TLS2_k127_3468542_58 carbohydrate transport K02027 - - 0.00000000000000000000005336 113.0
TLS2_k127_3468542_59 Mannose-6-phosphate isomerase - - - 0.000000000000000000001374 98.0
TLS2_k127_3468542_6 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002928 430.0
TLS2_k127_3468542_60 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000001557 97.0
TLS2_k127_3468542_61 - - - - 0.00000000000000953 79.0
TLS2_k127_3468542_62 PBS lyase K22221 - - 0.0000000000003645 81.0
TLS2_k127_3468542_63 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.000000002229 61.0
TLS2_k127_3468542_64 protein containing LysM domain - - - 0.0000002071 58.0
TLS2_k127_3468542_65 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.000002485 61.0
TLS2_k127_3468542_66 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.000003279 60.0
TLS2_k127_3468542_68 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00008172 47.0
TLS2_k127_3468542_7 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 422.0
TLS2_k127_3468542_8 Oxidoreductase K10219 - 1.1.1.312 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 413.0
TLS2_k127_3468542_9 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000536 417.0
TLS2_k127_3469031_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 3.051e-263 834.0
TLS2_k127_3469031_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 1.087e-223 710.0
TLS2_k127_3469031_10 Low molecular weight phosphotyrosine protein phosphatase K03741,K18701 - 1.20.4.1,2.8.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000001985 253.0
TLS2_k127_3469031_11 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000007806 252.0
TLS2_k127_3469031_12 Low molecular weight phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000134 207.0
TLS2_k127_3469031_13 Cell wall hydrolase autolysin K01448 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 0.000000000000000000000000000000000000000002303 168.0
TLS2_k127_3469031_14 Putative single-stranded nucleic acids-binding domain K06346 - - 0.00000000000000000000000000000007458 137.0
TLS2_k127_3469031_15 belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000125 130.0
TLS2_k127_3469031_16 Membrane protein insertase, YidC Oxa1 family K03217 - - 0.00000000000000000000000001165 120.0
TLS2_k127_3469031_17 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000277 106.0
TLS2_k127_3469031_18 Belongs to the peptidase S8 family - - - 0.0000000000000000001497 102.0
TLS2_k127_3469031_19 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.00000000000000003048 89.0
TLS2_k127_3469031_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 408.0
TLS2_k127_3469031_20 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.000000000002336 79.0
TLS2_k127_3469031_21 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000003406 62.0
TLS2_k127_3469031_22 ribonuclease P activity K03536,K08998 GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 0.00000001144 62.0
TLS2_k127_3469031_23 Transmembrane domain of unknown function (DUF3566) - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000009611 60.0
TLS2_k127_3469031_25 Protein of unknown function (DUF721) - - - 0.0008573 46.0
TLS2_k127_3469031_3 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 366.0
TLS2_k127_3469031_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005524 353.0
TLS2_k127_3469031_5 ATPase MipZ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 340.0
TLS2_k127_3469031_6 DNA polymerase III beta subunit K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007938 282.0
TLS2_k127_3469031_7 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001111 260.0
TLS2_k127_3469031_8 Pyridine nucleotide-disulphide oxidoreductase K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000004232 252.0
TLS2_k127_3469031_9 PFAM Sodium hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005051 264.0
TLS2_k127_3763912_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 5.709e-302 941.0
TLS2_k127_3763912_1 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006824 397.0
TLS2_k127_3763912_2 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 289.0
TLS2_k127_3763912_3 Protein of unknown function (DUF2587) - GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 - 0.0000000000000000000000000000000000002077 145.0
TLS2_k127_3763912_4 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.00000000000000000000000001873 110.0
TLS2_k127_3763912_5 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000001787 93.0
TLS2_k127_3763912_6 Putative Flp pilus-assembly TadE/G-like - - - 0.000002818 60.0
TLS2_k127_3763912_7 TadE-like protein - - - 0.00001639 54.0
TLS2_k127_3763912_8 TadE-like protein - - - 0.0001036 52.0
TLS2_k127_3763912_9 TadE-like protein - - - 0.000402 50.0
TLS2_k127_3813596_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1155.0
TLS2_k127_3813596_1 von Willebrand factor, type A K07114 - - 2.553e-253 835.0
TLS2_k127_3813596_10 Glutamine amidotransferase class-I K02501 - - 0.00000000000000000000000000000000000000000000000008338 185.0
TLS2_k127_3813596_11 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000003551 187.0
TLS2_k127_3813596_12 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000003774 183.0
TLS2_k127_3813596_13 translation release factor activity - - - 0.0000000000000000000000000000000000002857 154.0
TLS2_k127_3813596_14 SatD family (SatD) - - - 0.0000000000000000000000000000000251 134.0
TLS2_k127_3813596_15 translation initiation factor activity - - - 0.000000000000000000000000000006609 136.0
TLS2_k127_3813596_16 Psort location CytoplasmicMembrane, score - - - 0.00000000000003597 81.0
TLS2_k127_3813596_2 associated with various cellular activities K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 369.0
TLS2_k127_3813596_3 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004171 335.0
TLS2_k127_3813596_4 Cytochrome c-type biogenesis protein CcmF K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 312.0
TLS2_k127_3813596_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006335 296.0
TLS2_k127_3813596_6 D-alanyl-D-alanine carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 297.0
TLS2_k127_3813596_7 histidinol-phosphate transaminase activity K00817,K01814 GO:0000105,GO:0003674,GO:0003824,GO:0004400,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0010038,GO:0010045,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000001678 263.0
TLS2_k127_3813596_8 Imidazoleglycerol-phosphate dehydratase K00817,K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,3.1.3.15,4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000008729 236.0
TLS2_k127_3813596_9 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000004435 192.0
TLS2_k127_3876863_0 Uncharacterised protein family (UPF0182) K09118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 632.0
TLS2_k127_3876863_1 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 453.0
TLS2_k127_3876863_10 Belongs to the peptidase S16 family K07177 - - 0.00000000000000000000000000000000000000000000000000001566 203.0
TLS2_k127_3876863_11 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000000000000008891 196.0
TLS2_k127_3876863_12 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000332 185.0
TLS2_k127_3876863_13 - - - - 0.000000000000000000000000000000000000000000000003516 183.0
TLS2_k127_3876863_14 - - - - 0.0000000000000000000000000000000000000000001324 166.0
TLS2_k127_3876863_15 BioY family K03523 - - 0.000000000000000000000000000000000000000003143 161.0
TLS2_k127_3876863_16 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000000000000000000000000004433 164.0
TLS2_k127_3876863_17 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.00000000000000000000000000000000000006548 147.0
TLS2_k127_3876863_18 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000001609 103.0
TLS2_k127_3876863_2 pfam abc K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005118 368.0
TLS2_k127_3876863_20 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000000000000001253 81.0
TLS2_k127_3876863_21 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000003261 79.0
TLS2_k127_3876863_22 Glyoxalase-like domain - - - 0.0000000002202 66.0
TLS2_k127_3876863_23 Cytochrome c K00406 - - 0.00000001057 66.0
TLS2_k127_3876863_24 - - - - 0.00000004294 59.0
TLS2_k127_3876863_25 DivIVA protein K04074 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000005282 59.0
TLS2_k127_3876863_26 Enoyl-(Acyl carrier protein) reductase - - - 0.000006097 50.0
TLS2_k127_3876863_3 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 352.0
TLS2_k127_3876863_4 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006652 357.0
TLS2_k127_3876863_5 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 350.0
TLS2_k127_3876863_6 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 306.0
TLS2_k127_3876863_7 Domain of unknown function (DUF4389) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007859 299.0
TLS2_k127_3876863_8 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002214 285.0
TLS2_k127_3876863_9 ABC-type branched-chain amino acid transport - - - 0.00000000000000000000000000000000000000000000000000000000000541 225.0
TLS2_k127_3939575_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.0 1483.0
TLS2_k127_3939575_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.7.8 1.517e-245 783.0
TLS2_k127_3939575_10 Belongs to the ribF family K11753 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000003014 235.0
TLS2_k127_3939575_11 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000000000000004353 213.0
TLS2_k127_3939575_12 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.0000000000000000000000000000000000000003274 158.0
TLS2_k127_3939575_13 Pfam Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000003873 143.0
TLS2_k127_3939575_14 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000005177 135.0
TLS2_k127_3939575_15 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000000000004004 141.0
TLS2_k127_3939575_16 Putative adhesin - - - 0.0000000000000000000001172 108.0
TLS2_k127_3939575_17 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.0000000000000000000002547 103.0
TLS2_k127_3939575_18 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000006805 82.0
TLS2_k127_3939575_19 Protein of unknown function (DUF503) K09764 - - 0.00000000004947 66.0
TLS2_k127_3939575_2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 6.439e-200 643.0
TLS2_k127_3939575_20 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000004352 61.0
TLS2_k127_3939575_21 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.000000003675 68.0
TLS2_k127_3939575_3 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008393 479.0
TLS2_k127_3939575_4 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000646 449.0
TLS2_k127_3939575_5 Histidinol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 394.0
TLS2_k127_3939575_6 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 378.0
TLS2_k127_3939575_7 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008542 290.0
TLS2_k127_3939575_8 DHH family K06881 GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000006717 273.0
TLS2_k127_3939575_9 impB/mucB/samB family K14161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000134 278.0
TLS2_k127_3945093_0 PFAM isocitrate isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004562 583.0
TLS2_k127_3945093_1 Histidine ammonia-lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003326 498.0
TLS2_k127_3945093_10 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 - 1.13.11.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 372.0
TLS2_k127_3945093_11 Part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 351.0
TLS2_k127_3945093_12 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000659 370.0
TLS2_k127_3945093_13 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 341.0
TLS2_k127_3945093_14 Belongs to the NadC ModD family K00767,K03813 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 310.0
TLS2_k127_3945093_15 Drug resistance transporter, bcr cfla subfamily K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 310.0
TLS2_k127_3945093_16 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0040007,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 303.0
TLS2_k127_3945093_17 Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000104 299.0
TLS2_k127_3945093_18 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001323 276.0
TLS2_k127_3945093_19 Cobalt ABC transporter K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001892 258.0
TLS2_k127_3945093_2 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 490.0
TLS2_k127_3945093_20 KR domain - - - 0.0000000000000000000000000000000000000000000000000000001512 203.0
TLS2_k127_3945093_22 Methyltransferase small domain - - - 0.000000000000000000000000000000000000000000000000000002379 204.0
TLS2_k127_3945093_23 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000001027 192.0
TLS2_k127_3945093_24 Acyltransferase - - - 0.00000000000000000000000000000000000000003174 158.0
TLS2_k127_3945093_25 Endoribonuclease L-PSP - - - 0.0000000000000000000000000009103 117.0
TLS2_k127_3945093_26 CoA-binding domain protein K06929 - - 0.0000000000000000000000002067 110.0
TLS2_k127_3945093_27 Belongs to the Fur family K03711,K09825 - - 0.000000000000000000000001953 108.0
TLS2_k127_3945093_28 PAS PAC sensor signal transduction histidine kinase K18350 - 2.7.13.3 0.000000000000000000000009725 117.0
TLS2_k127_3945093_29 YCII-related domain - - - 0.000000000000000000000303 96.0
TLS2_k127_3945093_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009657 479.0
TLS2_k127_3945093_30 - - - - 0.000000000000000000006969 109.0
TLS2_k127_3945093_31 Rhodanese Homology Domain - - - 0.0000000000000002713 88.0
TLS2_k127_3945093_32 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000001526 85.0
TLS2_k127_3945093_33 - - - - 0.00000002069 67.0
TLS2_k127_3945093_34 - - - - 0.00000002577 61.0
TLS2_k127_3945093_4 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 466.0
TLS2_k127_3945093_5 Selenocysteine lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009973 438.0
TLS2_k127_3945093_6 Quinolinate synthetase A protein K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 418.0
TLS2_k127_3945093_7 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 407.0
TLS2_k127_3945093_8 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004461 400.0
TLS2_k127_3945093_9 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 392.0
TLS2_k127_4035160_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1217.0
TLS2_k127_4035160_1 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 568.0
TLS2_k127_4035160_10 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 GO:0008150,GO:0040007 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005234 325.0
TLS2_k127_4035160_11 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 322.0
TLS2_k127_4035160_12 PFAM FAD dependent oxidoreductase K09471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 310.0
TLS2_k127_4035160_13 molybdopterin biosynthesis K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000983 298.0
TLS2_k127_4035160_14 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003575 289.0
TLS2_k127_4035160_15 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001131 285.0
TLS2_k127_4035160_16 PFAM peptidase C45 acyl-coenzyme A 6-aminopenicillanic acid acyl-transferase K19200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006945 269.0
TLS2_k127_4035160_17 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006853 257.0
TLS2_k127_4035160_18 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000546 239.0
TLS2_k127_4035160_19 Belongs to the DapB family K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000001805 234.0
TLS2_k127_4035160_2 Belongs to the aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 498.0
TLS2_k127_4035160_20 Enoyl-CoA hydratase K01692,K13766 - 4.2.1.17,4.2.1.18 0.0000000000000000000000000000000000000000000000000002559 201.0
TLS2_k127_4035160_21 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000136 173.0
TLS2_k127_4035160_22 Utp--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000002069 183.0
TLS2_k127_4035160_23 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000003343 176.0
TLS2_k127_4035160_24 HD domain - - - 0.00000000000000000000000000000000000000009116 168.0
TLS2_k127_4035160_25 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.0000000000000000000000000000000000000001122 160.0
TLS2_k127_4035160_26 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000002504 154.0
TLS2_k127_4035160_27 SnoaL-like polyketide cyclase K15945 - - 0.0000000000000000000000000000000000000004636 155.0
TLS2_k127_4035160_28 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 0.0000000000000000000000000000000000001427 148.0
TLS2_k127_4035160_29 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.0000000000000000000000000000000004312 141.0
TLS2_k127_4035160_3 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 417.0
TLS2_k127_4035160_30 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000001667 144.0
TLS2_k127_4035160_31 PFAM Translin K07477 - - 0.000000000000000000000000000001331 125.0
TLS2_k127_4035160_32 Transcriptional regulator - - - 0.000000000000000000000000000004211 129.0
TLS2_k127_4035160_33 Domain of unknown function (DUF4349) - - - 0.0000000000000000000000000001986 128.0
TLS2_k127_4035160_34 - - - - 0.00000000000000000000000002411 116.0
TLS2_k127_4035160_35 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.00000000000000000000002936 106.0
TLS2_k127_4035160_36 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000004512 99.0
TLS2_k127_4035160_37 Putative regulatory protein - - - 0.000000000000000000512 90.0
TLS2_k127_4035160_38 Family of unknown function (DUF5317) - - - 0.00000000000000001224 91.0
TLS2_k127_4035160_39 Domain of unknown function (DUF4870) K09940 - - 0.00000000000000003032 88.0
TLS2_k127_4035160_4 Major Facilitator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004646 413.0
TLS2_k127_4035160_41 - - - - 0.000000000001144 77.0
TLS2_k127_4035160_42 Protein of unknown function (DUF2752) - - - 0.000000000279 72.0
TLS2_k127_4035160_43 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.000000001572 67.0
TLS2_k127_4035160_44 Helix-hairpin-helix domain - - - 0.00001316 57.0
TLS2_k127_4035160_5 Belongs to the arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 378.0
TLS2_k127_4035160_6 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 364.0
TLS2_k127_4035160_7 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000593 356.0
TLS2_k127_4035160_8 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003732 344.0
TLS2_k127_4035160_9 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 333.0
TLS2_k127_4105447_0 PFAM sodium hydrogen exchanger - - - 1.487e-211 680.0
TLS2_k127_4105447_1 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K05565,K14086 - - 4.941e-194 630.0
TLS2_k127_4105447_10 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 328.0
TLS2_k127_4105447_11 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 315.0
TLS2_k127_4105447_12 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001114 278.0
TLS2_k127_4105447_13 Cobalamin B12-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000007869 225.0
TLS2_k127_4105447_14 O-acetyl-ADP-ribose deacetylase 1 - - - 0.00000000000000000000000000000000000000000000000000000008324 199.0
TLS2_k127_4105447_15 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000008309 205.0
TLS2_k127_4105447_16 YjbR - - - 0.00000000000000000000000000000000000000000000003364 177.0
TLS2_k127_4105447_17 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000000004697 153.0
TLS2_k127_4105447_18 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000008062 158.0
TLS2_k127_4105447_19 Multisubunit Na H antiporter MnhC subunit K05567 - - 0.0000000000000000000000000000000001588 142.0
TLS2_k127_4105447_2 oxidoreductase K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 581.0
TLS2_k127_4105447_20 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K05565,K14086 - - 0.0000000000000000000000000000006127 127.0
TLS2_k127_4105447_21 TIGRFAM deazaflavin-dependent nitroreductase family protein - - - 0.00000000000000000000000000009002 121.0
TLS2_k127_4105447_22 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.0000000000000000000000001109 114.0
TLS2_k127_4105447_23 Na+/H+ ion antiporter subunit K05569 - - 0.000000000000000000000005251 110.0
TLS2_k127_4105447_24 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000001504 110.0
TLS2_k127_4105447_25 amidohydrolase - - - 0.000000000000000000003463 109.0
TLS2_k127_4105447_26 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.00000000000004212 76.0
TLS2_k127_4105447_27 Belongs to the universal stress protein A family - - - 0.000000003302 67.0
TLS2_k127_4105447_28 Amidohydrolase family - - - 0.000000009666 68.0
TLS2_k127_4105447_29 UPF0678 fatty acid-binding protein-like protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000001312 58.0
TLS2_k127_4105447_3 Proton-conducting membrane transporter K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 577.0
TLS2_k127_4105447_30 - - - - 0.000004554 52.0
TLS2_k127_4105447_4 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033,K12369 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 428.0
TLS2_k127_4105447_5 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 421.0
TLS2_k127_4105447_6 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 400.0
TLS2_k127_4105447_7 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K12370 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000041 377.0
TLS2_k127_4105447_8 ABC-type dipeptide transport system, periplasmic component K02035,K12368 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 347.0
TLS2_k127_4105447_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002846 340.0
TLS2_k127_4252778_0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal K00648 - 2.3.1.180 2.445e-204 654.0
TLS2_k127_4252778_1 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 532.0
TLS2_k127_4252778_2 Beta propeller domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005319 449.0
TLS2_k127_4252778_3 RNase_H superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005819 273.0
TLS2_k127_4252778_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001395 247.0
TLS2_k127_4252778_5 Acetyltransferase (GNAT) family K00657 - 2.3.1.57 0.0000000000000000000000000000000000000000000000000000000001043 210.0
TLS2_k127_4252778_6 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.0005671 53.0
TLS2_k127_4267218_0 Molybdopterin oxidoreductase - - - 0.0 1399.0
TLS2_k127_4267218_1 C-terminal, D2-small domain, of ClpB protein K03695,K03696 - - 0.0 1363.0
TLS2_k127_4267218_10 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000631 548.0
TLS2_k127_4267218_11 Belongs to the binding-protein-dependent transport system permease family K10544 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 549.0
TLS2_k127_4267218_12 Xaa-Pro aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008047 533.0
TLS2_k127_4267218_13 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 497.0
TLS2_k127_4267218_14 PFAM Rh family protein ammonium transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006811 491.0
TLS2_k127_4267218_15 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 462.0
TLS2_k127_4267218_16 ABC transporter substrate-binding protein K10543 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 429.0
TLS2_k127_4267218_17 beta-1,4-mannooligosaccharide phosphorylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 408.0
TLS2_k127_4267218_18 ABC transporter, ATP-binding protein K10545 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006498 370.0
TLS2_k127_4267218_19 Glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 362.0
TLS2_k127_4267218_2 ATPase P-type (Transporting), HAD superfamily, subfamily IC - - - 0.0 1079.0
TLS2_k127_4267218_20 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006032 361.0
TLS2_k127_4267218_21 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000541 363.0
TLS2_k127_4267218_22 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K02351,K07245,K21071 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009256 347.0
TLS2_k127_4267218_23 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 332.0
TLS2_k127_4267218_24 Highly conserved protein containing a thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 314.0
TLS2_k127_4267218_25 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003852 311.0
TLS2_k127_4267218_26 PFAM ROK family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 307.0
TLS2_k127_4267218_27 ANTAR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003349 265.0
TLS2_k127_4267218_28 electron transport chain K00347,K03614,K21163 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000001697 267.0
TLS2_k127_4267218_29 ABC-type molybdate transport system, permease component K02018 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000002583 232.0
TLS2_k127_4267218_3 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 5.075e-289 903.0
TLS2_k127_4267218_30 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000006563 236.0
TLS2_k127_4267218_31 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000008856 239.0
TLS2_k127_4267218_32 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.0000000000000000000000000000000000000000000000000000000000001942 222.0
TLS2_k127_4267218_33 - - - - 0.000000000000000000000000000000000000000000000000000000000008411 213.0
TLS2_k127_4267218_34 Sodium/calcium exchanger protein K07301 - - 0.00000000000000000000000000000000000000000000000000000000002447 223.0
TLS2_k127_4267218_35 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000005844 194.0
TLS2_k127_4267218_36 COG0589 Universal stress protein UspA and related K14055 - - 0.000000000000000000000000000000000000000000000003055 185.0
TLS2_k127_4267218_37 Belongs to the ABC transporter superfamily K02017 - 3.6.3.29 0.0000000000000000000000000000000000000000000006373 175.0
TLS2_k127_4267218_38 ANTAR - - - 0.000000000000000000000000000000000000000000001795 175.0
TLS2_k127_4267218_39 Activator of Hsp90 ATPase 1 family - - - 0.000000000000000000000000000000000000000002743 161.0
TLS2_k127_4267218_4 PFAM carbohydrate kinase K00854 - 2.7.1.17 3.212e-211 668.0
TLS2_k127_4267218_40 membrane - - - 0.000000000000000000000000000000000000004176 156.0
TLS2_k127_4267218_41 regulatory protein, arsR - - - 0.00000000000000000000000000000000000002962 146.0
TLS2_k127_4267218_43 chaperone-mediated protein complex assembly K00373,K17052 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - 0.00000000000000000000000000000000001173 149.0
TLS2_k127_4267218_44 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000157 136.0
TLS2_k127_4267218_45 Cytochrome c - - - 0.00000000000000000000000000000002437 135.0
TLS2_k127_4267218_46 Bacterial-like globin K06886 - - 0.00000000000000000000000000000002637 131.0
TLS2_k127_4267218_47 Metal-sensitive transcriptional repressor K21600 - - 0.000000000000000000000000000001471 122.0
TLS2_k127_4267218_48 - - - - 0.000000000000000000000000000006323 126.0
TLS2_k127_4267218_49 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000005145 123.0
TLS2_k127_4267218_5 Luciferase-like monooxygenase - - - 3.892e-211 660.0
TLS2_k127_4267218_50 Beta-lactamase enzyme family - - - 0.0000000000000000000000000003664 132.0
TLS2_k127_4267218_51 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000001572 118.0
TLS2_k127_4267218_52 protein complex oligomerization - - - 0.0000000000000000000001088 110.0
TLS2_k127_4267218_53 binding domain K03750,K07219 - 2.10.1.1 0.000000000000000000001896 106.0
TLS2_k127_4267218_54 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000004617 98.0
TLS2_k127_4267218_55 Metal-sensitive transcriptional repressor K21600 - - 0.0000000000000004814 87.0
TLS2_k127_4267218_56 Universal stress protein family - - - 0.000000000000003028 81.0
TLS2_k127_4267218_57 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000001367 74.0
TLS2_k127_4267218_58 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - 0.000000000002914 74.0
TLS2_k127_4267218_59 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000003066 66.0
TLS2_k127_4267218_6 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01667,K01668 - 4.1.99.1,4.1.99.2 1.026e-199 632.0
TLS2_k127_4267218_60 Short C-terminal domain K08982 - - 0.00000004076 57.0
TLS2_k127_4267218_61 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000004396 61.0
TLS2_k127_4267218_62 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.00000294 51.0
TLS2_k127_4267218_63 RelA SpoT domain protein - - - 0.000003768 55.0
TLS2_k127_4267218_64 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase K01227 - 3.2.1.96 0.00009879 55.0
TLS2_k127_4267218_7 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 599.0
TLS2_k127_4267218_8 Belongs to the xylose isomerase family K01805 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 596.0
TLS2_k127_4267218_9 nitrate reductase beta subunit K00371,K16965,K17048,K17051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 573.0
TLS2_k127_4275929_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 4.2.1.9 5.284e-234 736.0
TLS2_k127_4275929_1 PFAM aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 6.299e-216 695.0
TLS2_k127_4275929_10 Glycerol acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 331.0
TLS2_k127_4275929_11 ABC-type sugar transport system periplasmic component K10232 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 327.0
TLS2_k127_4275929_12 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 325.0
TLS2_k127_4275929_13 SMART ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 303.0
TLS2_k127_4275929_14 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 287.0
TLS2_k127_4275929_15 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001578 257.0
TLS2_k127_4275929_16 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000005397 255.0
TLS2_k127_4275929_17 ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000169 237.0
TLS2_k127_4275929_18 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000001225 223.0
TLS2_k127_4275929_19 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000006644 135.0
TLS2_k127_4275929_2 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 9.444e-197 629.0
TLS2_k127_4275929_20 Pfam Zn-finger in ubiquitin-hydrolases and other protein K03455 - - 0.0000000000000000000000000009103 117.0
TLS2_k127_4275929_21 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000000001134 124.0
TLS2_k127_4275929_22 SnoaL-like domain - - - 0.00000000000000000000000001583 119.0
TLS2_k127_4275929_23 universal stress protein - - - 0.00000000000000000001774 102.0
TLS2_k127_4275929_24 RDD family - - - 0.0000000001667 72.0
TLS2_k127_4275929_3 Glycosyl hydrolase family 1 K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 479.0
TLS2_k127_4275929_4 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 466.0
TLS2_k127_4275929_5 ATPases associated with a variety of cellular activities K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 458.0
TLS2_k127_4275929_6 Domain of unknown function (DUF4032) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 416.0
TLS2_k127_4275929_7 ABC-type sugar transport system, permease component K10234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007717 358.0
TLS2_k127_4275929_8 COG1175 ABC-type sugar transport systems permease components K10233 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002906 345.0
TLS2_k127_4275929_9 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 336.0
TLS2_k127_4529023_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 597.0
TLS2_k127_4529023_1 Cell shape determining protein MreB Mrl K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 469.0
TLS2_k127_4529023_10 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000511 278.0
TLS2_k127_4529023_11 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000008475 284.0
TLS2_k127_4529023_12 Alanine dehydrogenase/PNT, C-terminal domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007286 271.0
TLS2_k127_4529023_13 Belongs to the SEDS family K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001126 265.0
TLS2_k127_4529023_14 Bacterial trigger factor protein (TF) C-terminus K03545 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000002598 247.0
TLS2_k127_4529023_15 PFAM Thymidine kinase K00857 - 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000008386 233.0
TLS2_k127_4529023_16 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.000000000000000000000000000000000000000000000001916 181.0
TLS2_k127_4529023_17 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000001745 143.0
TLS2_k127_4529023_18 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000002123 121.0
TLS2_k127_4529023_19 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000005049 122.0
TLS2_k127_4529023_2 Ribonuclease E/G family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 473.0
TLS2_k127_4529023_20 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000002174 116.0
TLS2_k127_4529023_21 cheY-homologous receiver domain - - - 0.000000000000000000000005786 105.0
TLS2_k127_4529023_22 Prokaryotic dksA/traR C4-type zinc finger - - - 0.0000000000000000002293 91.0
TLS2_k127_4529023_23 - - - - 0.00000000000005978 86.0
TLS2_k127_4529023_24 - - - - 0.000000000006371 69.0
TLS2_k127_4529023_25 Lysin motif - - - 0.00000002135 63.0
TLS2_k127_4529023_26 - - - - 0.0000002455 57.0
TLS2_k127_4529023_27 Involved in formation and maintenance of cell shape K03570 - - 0.00003044 55.0
TLS2_k127_4529023_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 435.0
TLS2_k127_4529023_4 VWA domain containing CoxE-like protein K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 431.0
TLS2_k127_4529023_5 Cation transport protein K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003715 415.0
TLS2_k127_4529023_6 AAA domain (Cdc48 subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 362.0
TLS2_k127_4529023_7 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004905 355.0
TLS2_k127_4529023_8 Belongs to the folylpolyglutamate synthase family K11754 GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 309.0
TLS2_k127_4529023_9 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001579 279.0
TLS2_k127_4596619_0 Creatinase/Prolidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004837 364.0
TLS2_k127_4596619_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 342.0
TLS2_k127_4596619_10 Carboxypeptidase regulatory-like domain - - - 0.0003331 51.0
TLS2_k127_4596619_2 PIN domain - - - 0.0000000000000000000000000000000000000002047 154.0
TLS2_k127_4596619_3 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000145 142.0
TLS2_k127_4596619_4 - - - - 0.00000000000000000000000006503 123.0
TLS2_k127_4596619_5 toxin-antitoxin pair type II binding - - - 0.00000000000000000000003422 102.0
TLS2_k127_4596619_6 Belongs to the peptidase S8 family - - - 0.0000000000000000002269 101.0
TLS2_k127_4596619_7 cell wall organization K18197 - 4.2.2.23 0.000000000000002886 89.0
TLS2_k127_4596619_8 S-layer homology domain - - - 0.000008629 56.0
TLS2_k127_4596619_9 Belongs to the peptidase S8 family - - - 0.00001174 55.0
TLS2_k127_4692810_0 Clp amino terminal domain, pathogenicity island component K03696 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944 - 0.0 1148.0
TLS2_k127_4692810_1 Belongs to the glycosyl hydrolase 3 family - - - 1.503e-301 957.0
TLS2_k127_4692810_10 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008112 539.0
TLS2_k127_4692810_11 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 517.0
TLS2_k127_4692810_12 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008384 507.0
TLS2_k127_4692810_13 COG0659 Sulfate permease and related transporters (MFS superfamily) K01673,K03321 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 491.0
TLS2_k127_4692810_14 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 475.0
TLS2_k127_4692810_15 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 468.0
TLS2_k127_4692810_16 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 466.0
TLS2_k127_4692810_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 453.0
TLS2_k127_4692810_18 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005424 462.0
TLS2_k127_4692810_19 helix_turn _helix lactose operon repressor K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 442.0
TLS2_k127_4692810_2 UvrD-like helicase C-terminal domain K03657 GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 2.667e-240 764.0
TLS2_k127_4692810_20 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004829 441.0
TLS2_k127_4692810_21 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002708 426.0
TLS2_k127_4692810_22 Bacterial extracellular solute-binding protein K10117 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 419.0
TLS2_k127_4692810_23 Binding-protein-dependent transport systems inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 387.0
TLS2_k127_4692810_24 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 362.0
TLS2_k127_4692810_25 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000519 356.0
TLS2_k127_4692810_26 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006041 364.0
TLS2_k127_4692810_27 Binding-protein-dependent transport system inner membrane component K02025,K10118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 348.0
TLS2_k127_4692810_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 326.0
TLS2_k127_4692810_29 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 324.0
TLS2_k127_4692810_3 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 2.204e-226 719.0
TLS2_k127_4692810_30 Binding-protein-dependent transport systems inner membrane component K02026,K10119,K17243 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003496 314.0
TLS2_k127_4692810_31 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 321.0
TLS2_k127_4692810_32 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005918 305.0
TLS2_k127_4692810_33 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 299.0
TLS2_k127_4692810_34 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004568 269.0
TLS2_k127_4692810_35 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000001234 270.0
TLS2_k127_4692810_36 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000002567 273.0
TLS2_k127_4692810_37 ATP-binding region, ATPase domain protein K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000002317 282.0
TLS2_k127_4692810_38 gtp cyclohydrolase i K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000004935 259.0
TLS2_k127_4692810_39 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000003414 259.0
TLS2_k127_4692810_4 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.468e-217 687.0
TLS2_k127_4692810_40 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000005043 249.0
TLS2_k127_4692810_41 pfkB family carbohydrate kinase K00882 - 2.7.1.56 0.000000000000000000000000000000000000000000000000000000000000000000000003162 254.0
TLS2_k127_4692810_42 Pfam:Zinicin_2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000335 247.0
TLS2_k127_4692810_43 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000671 239.0
TLS2_k127_4692810_44 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001614 244.0
TLS2_k127_4692810_45 Siderophore biosynthesis protein domain K00663 - 2.3.1.82 0.0000000000000000000000000000000000000000000000000000000000000000001657 234.0
TLS2_k127_4692810_46 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000000000000004909 225.0
TLS2_k127_4692810_47 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000001252 224.0
TLS2_k127_4692810_48 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000002559 215.0
TLS2_k127_4692810_49 Belongs to the FPP GGPP synthase family K00805,K21275 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.30,2.5.1.83 0.00000000000000000000000000000000000000000000000000000005914 209.0
TLS2_k127_4692810_5 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 588.0
TLS2_k127_4692810_50 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000002909 198.0
TLS2_k127_4692810_51 membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000003776 216.0
TLS2_k127_4692810_52 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000004971 194.0
TLS2_k127_4692810_53 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000007844 186.0
TLS2_k127_4692810_54 survival protein SurE K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000003983 168.0
TLS2_k127_4692810_55 NADH ubiquinone oxidoreductase 24 kD subunit K00334 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000000000000000000000000009826 165.0
TLS2_k127_4692810_56 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000103 156.0
TLS2_k127_4692810_57 Transcriptional regulator PadR-like family K10947 - - 0.000000000000000000000000000000000000005314 148.0
TLS2_k127_4692810_58 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000006968 156.0
TLS2_k127_4692810_59 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00332 - 1.6.5.3 0.0000000000000000000000000000000000001627 149.0
TLS2_k127_4692810_6 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 610.0
TLS2_k127_4692810_60 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000005067 150.0
TLS2_k127_4692810_61 transcriptional regulator - - - 0.00000000000000000000000000000000004882 147.0
TLS2_k127_4692810_62 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000003739 149.0
TLS2_k127_4692810_63 Sporulation and spore germination - - - 0.0000000000000000000000000000000005336 144.0
TLS2_k127_4692810_64 TIGRFAM DNA polymerase III, delta prime subunit K02341 - 2.7.7.7 0.000000000000000000000000000000001684 142.0
TLS2_k127_4692810_65 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K00332 - 1.6.5.3 0.000000000000000000000000000000004535 141.0
TLS2_k127_4692810_66 - - - - 0.00000000000000000000000000000001093 129.0
TLS2_k127_4692810_67 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339,K05578 - 1.6.5.3 0.00000000000000000000000000000009975 131.0
TLS2_k127_4692810_68 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000000003237 128.0
TLS2_k127_4692810_69 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633,K13940 GO:0008150,GO:0040007 1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8 0.000000000000000000000000000001166 132.0
TLS2_k127_4692810_7 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 586.0
TLS2_k127_4692810_70 Transcriptional regulator - - - 0.00000000000000000000000000000217 129.0
TLS2_k127_4692810_71 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950,K13940 - 2.7.6.3,4.1.2.25 0.00000000000000000000000000003397 130.0
TLS2_k127_4692810_72 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 - 1.6.5.3 0.0000000000000000000000000008741 117.0
TLS2_k127_4692810_73 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.3 0.000000000000000000000000011 113.0
TLS2_k127_4692810_74 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000001192 119.0
TLS2_k127_4692810_75 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.00000000000000000000000006321 113.0
TLS2_k127_4692810_76 - - - - 0.00000000000000000000000198 113.0
TLS2_k127_4692810_77 MDMPI C-terminal domain - - - 0.00000000000000000000001704 109.0
TLS2_k127_4692810_78 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000001778 104.0
TLS2_k127_4692810_79 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins K03817 - - 0.0000000000000000000004294 104.0
TLS2_k127_4692810_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008202 552.0
TLS2_k127_4692810_80 Uncharacterized BCR, YaiI/YqxD family COG1671 K09768 - - 0.00000000000000000002558 96.0
TLS2_k127_4692810_81 Putative adhesin - - - 0.0000000000000000003518 97.0
TLS2_k127_4692810_82 PFAM peptidase M15B and M15C DD-carboxypeptidase VanY endolysin - - - 0.0000000000000003545 87.0
TLS2_k127_4692810_83 Putative zinc-finger - GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - 0.00000000003415 66.0
TLS2_k127_4692810_85 membrane - - - 0.0000000002019 73.0
TLS2_k127_4692810_86 protein encoded in hypervariable junctions of pilus gene clusters - - - 0.00000000468 64.0
TLS2_k127_4692810_87 Polymer-forming cytoskeletal - - - 0.00000004137 65.0
TLS2_k127_4692810_88 - - - - 0.0000002323 62.0
TLS2_k127_4692810_89 CAAX protease self-immunity K07052 - - 0.0000003097 60.0
TLS2_k127_4692810_9 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 554.0
TLS2_k127_4692810_90 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.00001339 57.0
TLS2_k127_47377_0 Belongs to the peptidase S8 family K14743 - - 0.000000000000000000000000000000000004204 156.0
TLS2_k127_47377_1 - - - - 0.0000000002854 73.0
TLS2_k127_4743199_0 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030312,GO:0030976,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 8.459e-222 702.0
TLS2_k127_4743199_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004337 445.0
TLS2_k127_4743199_2 acetolactate synthase K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.00000000000000000000000000000000000000000001499 168.0
TLS2_k127_4745191_0 alpha-L-arabinofuranosidase K01209 - 3.2.1.55 1.557e-218 688.0
TLS2_k127_4745191_1 DNA alkylation repair - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 389.0
TLS2_k127_4745191_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002961 263.0
TLS2_k127_4745191_3 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000006653 235.0
TLS2_k127_4745191_4 - - - - 0.0000000000000000000000000007012 121.0
TLS2_k127_4745191_5 Ion channel - - - 0.000000000000000002977 89.0
TLS2_k127_4745191_6 Diguanylate cyclase - - - 0.00000000268 70.0
TLS2_k127_4745191_7 CAAX protease self-immunity - - - 0.000001046 54.0
TLS2_k127_4745191_8 DNA-binding transcription factor activity - - - 0.00003024 47.0
TLS2_k127_4746994_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 6.3e-239 749.0
TLS2_k127_4746994_1 Tetratricopeptide repeat - - - 5.853e-216 709.0
TLS2_k127_4746994_10 blue (type 1) copper K00368 - 1.7.2.1 0.000003229 59.0
TLS2_k127_4746994_2 YidE YbjL duplication domain protein K07085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 536.0
TLS2_k127_4746994_3 NADPH:quinone reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006965 263.0
TLS2_k127_4746994_4 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000000000000000002809 145.0
TLS2_k127_4746994_5 N-acetylmuramoyl-L-alanine amidase - - - 0.0000000000000000000000000000000000002807 157.0
TLS2_k127_4746994_6 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000001764 135.0
TLS2_k127_4746994_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0001101,GO:0001666,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0036293,GO:0042221,GO:0044419,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051704,GO:0060255,GO:0065007,GO:0070482,GO:0080090,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000005759 123.0
TLS2_k127_4746994_8 D-alanyl-D-alanine carboxypeptidase - - - 0.0000000000000000000000002253 120.0
TLS2_k127_4746994_9 hydrolase (metallo-beta-lactamase superfamily) - - - 0.0000000624 65.0
TLS2_k127_4758035_0 Heat shock 70 kDa protein K04043 - - 5.939e-263 822.0
TLS2_k127_4758035_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 5.745e-224 713.0
TLS2_k127_4758035_10 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006015 444.0
TLS2_k127_4758035_11 N-4 methylation of cytosine K00571,K00590 - 2.1.1.113,2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 396.0
TLS2_k127_4758035_12 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 394.0
TLS2_k127_4758035_13 transport, permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 379.0
TLS2_k127_4758035_14 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 372.0
TLS2_k127_4758035_15 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 350.0
TLS2_k127_4758035_16 DNA primase, small subunit K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 344.0
TLS2_k127_4758035_17 ATP dependent DNA ligase domain - GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 345.0
TLS2_k127_4758035_18 Na+/Pi-cotransporter K03324,K14683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 335.0
TLS2_k127_4758035_19 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 325.0
TLS2_k127_4758035_2 Aminotransferase class-V - - - 2.802e-218 690.0
TLS2_k127_4758035_20 Domain of unknown function (DUF427) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006583 312.0
TLS2_k127_4758035_21 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 304.0
TLS2_k127_4758035_22 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008216 300.0
TLS2_k127_4758035_23 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001238 279.0
TLS2_k127_4758035_24 Short-chain Dehydrogenase reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001288 272.0
TLS2_k127_4758035_25 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001854 273.0
TLS2_k127_4758035_26 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000005732 253.0
TLS2_k127_4758035_27 - - - - 0.00000000000000000000000000000000000000000000000000000000000000006263 227.0
TLS2_k127_4758035_28 N-acetylmuramoyl-L-alanine amidase - - - 0.00000000000000000000000000000000000000000000000000000000001478 218.0
TLS2_k127_4758035_29 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000005279 203.0
TLS2_k127_4758035_3 ABC transporter transmembrane region K06147,K06148 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 571.0
TLS2_k127_4758035_30 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000001017 206.0
TLS2_k127_4758035_31 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01476,K01480 - 3.5.3.1,3.5.3.11 0.0000000000000000000000000000000000000000000000000000000524 217.0
TLS2_k127_4758035_32 sequence-specific DNA binding K00567,K13529,K15051 - 2.1.1.63,3.2.2.21 0.0000000000000000000000000000000000000000000000000000009203 204.0
TLS2_k127_4758035_33 CHAD - - - 0.0000000000000000000000000000000000000001036 171.0
TLS2_k127_4758035_34 NUDIX domain - - - 0.000000000000000000000000000000000000004286 155.0
TLS2_k127_4758035_35 DoxX K15977 - - 0.000000000000000000000000000000000002225 144.0
TLS2_k127_4758035_36 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000001503 136.0
TLS2_k127_4758035_37 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.0000000000000000000000000000000009708 139.0
TLS2_k127_4758035_38 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000008485 134.0
TLS2_k127_4758035_39 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000001393 126.0
TLS2_k127_4758035_4 ABC transporter transmembrane region K06147,K06148 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008673 565.0
TLS2_k127_4758035_40 helix_turn_helix, mercury resistance K13640 - - 0.000000000000000000000000000289 118.0
TLS2_k127_4758035_41 - - - - 0.00000000000000000000000000175 123.0
TLS2_k127_4758035_42 amidohydrolase - - - 0.000000000000000000000000064 124.0
TLS2_k127_4758035_43 Virulence factor BrkB K07058 - - 0.000000000000000000000000169 118.0
TLS2_k127_4758035_44 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.000000000000000000000001614 111.0
TLS2_k127_4758035_45 - - - - 0.000000000000000000000003594 108.0
TLS2_k127_4758035_46 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.00000000000000000000001965 113.0
TLS2_k127_4758035_47 rhs-related protein - - - 0.00000000000000000000007087 115.0
TLS2_k127_4758035_48 cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.0000000000000000000006266 101.0
TLS2_k127_4758035_49 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K15520 - 2.3.1.189 0.000000000000000000002569 101.0
TLS2_k127_4758035_5 Berberine and berberine like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 551.0
TLS2_k127_4758035_50 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000004716 104.0
TLS2_k127_4758035_51 PhoU domain - - - 0.0000000000000000001273 97.0
TLS2_k127_4758035_52 ABC-2 family transporter protein K01992 - - 0.000000000009049 75.0
TLS2_k127_4758035_53 HNH nucleases - - - 0.00000002372 65.0
TLS2_k127_4758035_6 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 507.0
TLS2_k127_4758035_7 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00303 - 1.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009637 464.0
TLS2_k127_4758035_8 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 453.0
TLS2_k127_4758035_9 Daunorubicin resistance ABC transporter ATP-binding subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 445.0
TLS2_k127_4761410_0 alpha amylase, catalytic K01187 - 3.2.1.20 1.392e-200 638.0
TLS2_k127_4761410_1 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007828 597.0
TLS2_k127_4761410_10 Parallel beta-helix repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001239 304.0
TLS2_k127_4761410_11 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008484 255.0
TLS2_k127_4761410_12 Isochorismatase family K08281 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000001553 235.0
TLS2_k127_4761410_13 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000002288 211.0
TLS2_k127_4761410_14 Protein of unknown function (DUF998) - - - 0.00000000000000000000000000000000000000000000000000000007481 203.0
TLS2_k127_4761410_15 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000000000000000000000444 205.0
TLS2_k127_4761410_16 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000001297 186.0
TLS2_k127_4761410_17 PhoQ Sensor - - - 0.00000000000000000000000000000000000000133 169.0
TLS2_k127_4761410_18 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000001414 151.0
TLS2_k127_4761410_19 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000001757 136.0
TLS2_k127_4761410_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004759 582.0
TLS2_k127_4761410_20 PspC domain - - - 0.000000000000000000000000001666 126.0
TLS2_k127_4761410_21 Belongs to the peptidase S8 family - - - 0.000000000000000000000009155 118.0
TLS2_k127_4761410_22 - - - - 0.00000000000000000001553 100.0
TLS2_k127_4761410_23 Glycosyl hydrolases family 25 - - - 0.0000000000000000005277 101.0
TLS2_k127_4761410_24 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18958 GO:0001101,GO:0008150,GO:0010033,GO:0033993,GO:0042221,GO:0046677,GO:0050896,GO:0070542,GO:1901700 - 0.000000000000003714 80.0
TLS2_k127_4761410_25 membrane - - - 0.00000000000002905 78.0
TLS2_k127_4761410_26 Sh3 type 3 domain protein - - - 0.0000000004458 63.0
TLS2_k127_4761410_27 - - - - 0.0000006188 53.0
TLS2_k127_4761410_28 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000003538 56.0
TLS2_k127_4761410_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 513.0
TLS2_k127_4761410_4 hydroperoxide reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 482.0
TLS2_k127_4761410_5 helicase superfamily c-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005089 443.0
TLS2_k127_4761410_6 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 404.0
TLS2_k127_4761410_7 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 309.0
TLS2_k127_4761410_8 metallopeptidase activity K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001348 300.0
TLS2_k127_4761410_9 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006443 283.0
TLS2_k127_4802620_0 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 469.0
TLS2_k127_4802620_1 spermidine synthase K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006871 411.0
TLS2_k127_4802620_2 TAP-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000841 368.0
TLS2_k127_4802620_3 Glycosidase - - - 0.000000000000000000000000000000000000000000000002583 175.0
TLS2_k127_4802620_4 Haemolysin-III related K11068 - - 0.00000000000000000000000000000002534 134.0
TLS2_k127_4802620_5 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.0000000000000000000000001105 109.0
TLS2_k127_4868978_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 0.0 1027.0
TLS2_k127_4868978_1 DNA polymerase beta thumb K02347 - - 2.158e-202 645.0
TLS2_k127_4868978_10 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000002633 169.0
TLS2_k127_4868978_11 Aminoacyl-tRNA editing domain K03976 - - 0.000000000000000000000000000000000000001039 153.0
TLS2_k127_4868978_12 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000001088 135.0
TLS2_k127_4868978_13 SnoaL-like domain - - - 0.000000000000000000000000000000004846 131.0
TLS2_k127_4868978_14 PAS domain K18350 - 2.7.13.3 0.00000000000000000000000000000003649 145.0
TLS2_k127_4868978_15 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00991 - 2.7.7.60 0.000000000000000000000000003098 120.0
TLS2_k127_4868978_16 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006323,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010556,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051276,GO:0060255,GO:0065007,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2001141 - 0.00000000000000001561 87.0
TLS2_k127_4868978_17 Helix-turn-helix domain - - - 0.00000000000000003465 89.0
TLS2_k127_4868978_18 Pfam:DUF385 - - - 0.0000000000000002613 84.0
TLS2_k127_4868978_19 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000001717 63.0
TLS2_k127_4868978_2 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 422.0
TLS2_k127_4868978_21 Type II secretion system (T2SS), protein F K12510 - - 0.00007036 55.0
TLS2_k127_4868978_3 SMART Nucleotide binding protein, PINc K07175 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 340.0
TLS2_k127_4868978_4 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006977 342.0
TLS2_k127_4868978_5 Secretion system protein K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 311.0
TLS2_k127_4868978_6 CAAX protease self-immunity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 299.0
TLS2_k127_4868978_7 ABC-type antimicrobial peptide transport system, ATPase component K02003,K05685 - - 0.00000000000000000000000000000000000000000000000000000001389 205.0
TLS2_k127_4868978_8 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000004295 203.0
TLS2_k127_4868978_9 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000008555 194.0
TLS2_k127_4935687_0 3-demethylubiquinone-9 3-O-methyltransferase activity K00384,K00568 - 1.8.1.9,2.1.1.222,2.1.1.64 1.743e-234 735.0
TLS2_k127_4935687_1 bifunctional deaminase-reductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 351.0
TLS2_k127_4935687_10 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000001557 155.0
TLS2_k127_4935687_11 peroxidase - GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0046686,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.0000000000000000000000000000000004558 132.0
TLS2_k127_4935687_12 PFAM Abortive infection protein - - - 0.0000000000000000001813 99.0
TLS2_k127_4935687_13 - - - - 0.0000000009374 59.0
TLS2_k127_4935687_14 PFAM Alpha beta hydrolase - - - 0.00000003456 64.0
TLS2_k127_4935687_15 Bacterial regulatory proteins, tetR family - - - 0.000001833 53.0
TLS2_k127_4935687_16 - - - - 0.0000181 55.0
TLS2_k127_4935687_2 transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 286.0
TLS2_k127_4935687_3 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000183 260.0
TLS2_k127_4935687_4 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009697 260.0
TLS2_k127_4935687_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000003864 239.0
TLS2_k127_4935687_6 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000000000000000000000000000009977 200.0
TLS2_k127_4935687_7 GrpB protein - - - 0.00000000000000000000000000000000000000000000002449 176.0
TLS2_k127_4935687_8 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000002356 183.0
TLS2_k127_4935687_9 - - - - 0.0000000000000000000000000000000000000009368 152.0
TLS2_k127_493596_0 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000002677 220.0
TLS2_k127_493596_1 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000000000001795 164.0
TLS2_k127_4961929_0 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000007656 133.0
TLS2_k127_4961929_1 Histidine kinase K03406,K07673,K07675 - 2.7.13.3 0.0000000000000000000007753 110.0
TLS2_k127_4979108_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 550.0
TLS2_k127_4979108_1 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004808 453.0
TLS2_k127_4979108_10 import. Responsible for energy coupling to the transport system - - - 0.00000000000000000000000000000000000000000000000000008912 212.0
TLS2_k127_4979108_11 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system - - - 0.0000000000000000000000000000000000000005572 153.0
TLS2_k127_4979108_12 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000000000000000006389 146.0
TLS2_k127_4979108_13 - - - - 0.00000000000000000702 96.0
TLS2_k127_4979108_14 - - - - 0.00000000000001609 79.0
TLS2_k127_4979108_16 Domain of unknown function (DUF4190) - - - 0.000000007401 67.0
TLS2_k127_4979108_2 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000534 446.0
TLS2_k127_4979108_3 Alkylmercury lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 318.0
TLS2_k127_4979108_4 Histidine kinase K02484 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 306.0
TLS2_k127_4979108_5 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 294.0
TLS2_k127_4979108_6 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001735 271.0
TLS2_k127_4979108_7 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003943 271.0
TLS2_k127_4979108_8 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000008683 231.0
TLS2_k127_4979108_9 Putative peptidoglycan binding domain - - - 0.000000000000000000000000000000000000000000000000000000009652 212.0
TLS2_k127_4979691_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0 1035.0
TLS2_k127_4979691_1 transcriptional K21884 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000002252 117.0
TLS2_k127_4979691_2 VanW like protein - - - 0.000000000009643 77.0
TLS2_k127_4986501_0 PFAM extracellular solute-binding protein family 1 K10232 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005385 416.0
TLS2_k127_4986501_1 PFAM Binding-protein-dependent transport system inner membrane component K10119,K10234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003557 353.0
TLS2_k127_4986501_2 COG1175 ABC-type sugar transport systems permease components K10233 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 310.0
TLS2_k127_4986501_3 PFAM glycoside hydrolase family 3 K01207 - 3.2.1.52 0.0000000004629 65.0
TLS2_k127_4986501_4 ROK family K00845 - 2.7.1.2 0.0000402 49.0
TLS2_k127_4986539_0 PFAM extracellular solute-binding protein family 1 K10232 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004289 421.0
TLS2_k127_4986539_1 PFAM Binding-protein-dependent transport system inner membrane component K10119,K10234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005979 349.0
TLS2_k127_4986539_2 COG1175 ABC-type sugar transport systems permease components K10233 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 311.0
TLS2_k127_4986539_3 PFAM glycoside hydrolase, family 3 domain protein K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000673 317.0
TLS2_k127_4986539_4 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004704 295.0
TLS2_k127_4986539_5 PFAM sugar isomerase (SIS) K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008899 291.0
TLS2_k127_4986539_6 ROK family K00845 - 2.7.1.2 0.000695 46.0
TLS2_k127_4999837_0 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003648 436.0
TLS2_k127_4999837_1 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005598 302.0
TLS2_k127_4999837_2 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005533 247.0
TLS2_k127_4999837_3 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000001789 155.0
TLS2_k127_5031051_0 ABC transporter - - - 0.0 1242.0
TLS2_k127_5031051_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 3.669e-253 799.0
TLS2_k127_5031051_10 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000002807 220.0
TLS2_k127_5031051_11 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000364 224.0
TLS2_k127_5031051_12 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000000000000025 203.0
TLS2_k127_5031051_13 Domain of unknown function (DUF4389) - - - 0.00000000000000000000000000000000000000000000000000006358 187.0
TLS2_k127_5031051_14 Hydroxypyruvate reductase K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000004368 188.0
TLS2_k127_5031051_15 ANTAR - - - 0.0000000000000000000000000000000000000000000004603 179.0
TLS2_k127_5031051_16 oxidoreductase activity, acting on CH-OH group of donors - - - 0.00000000000000000000000000000000000000000001039 172.0
TLS2_k127_5031051_17 Cytochrome c oxidase caa3-type, assembly factor K02351 - - 0.0000000000000000000000000000000000000003685 161.0
TLS2_k127_5031051_18 Belongs to the phosphoglycerate mutase family K22305 - 3.1.3.3 0.000000000000000000000000000000004032 143.0
TLS2_k127_5031051_19 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000007534 136.0
TLS2_k127_5031051_2 FAD binding domain - - - 2.207e-232 727.0
TLS2_k127_5031051_20 pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000008018 129.0
TLS2_k127_5031051_21 Phage integrase family - - - 0.00000000000000006773 87.0
TLS2_k127_5031051_22 Cytochrome c - - - 0.00000000000001381 83.0
TLS2_k127_5031051_23 COG0500 SAM-dependent methyltransferases - - - 0.00000000000005787 82.0
TLS2_k127_5031051_24 2-phospho-L-lactate guanylyltransferase K14941 - 2.7.7.68 0.000000000006098 73.0
TLS2_k127_5031051_25 AMP binding - - - 0.00000000002154 70.0
TLS2_k127_5031051_26 Septum formation - - - 0.00000000003003 72.0
TLS2_k127_5031051_27 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.0000000001594 68.0
TLS2_k127_5031051_28 antisigma factor binding K04749 - - 0.00000008098 59.0
TLS2_k127_5031051_3 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K15408 - 1.9.3.1 1.823e-214 692.0
TLS2_k127_5031051_30 Glyoxalase-like domain - - - 0.0000002254 62.0
TLS2_k127_5031051_31 PFAM Stage II sporulation protein E (SpoIIE) - - - 0.0003933 50.0
TLS2_k127_5031051_4 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 455.0
TLS2_k127_5031051_5 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 417.0
TLS2_k127_5031051_6 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 399.0
TLS2_k127_5031051_7 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 334.0
TLS2_k127_5031051_8 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 289.0
TLS2_k127_5031051_9 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000229 250.0
TLS2_k127_508247_0 Dihydrofolate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 373.0
TLS2_k127_508247_1 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 355.0
TLS2_k127_508247_2 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000003022 219.0
TLS2_k127_508247_3 TfoX N-terminal domain - - - 0.00000000000000000000000000000000000005047 145.0
TLS2_k127_508247_4 acetyltransferase - - - 0.00000002043 58.0
TLS2_k127_510185_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007033 361.0
TLS2_k127_510185_1 Cytochrome C biogenesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 306.0
TLS2_k127_510185_10 ABC transporter - - - 0.00000000000000000000000000000000000000000001563 171.0
TLS2_k127_510185_11 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000002051 175.0
TLS2_k127_510185_12 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000007329 169.0
TLS2_k127_510185_13 PFAM Bacterial regulatory proteins, gntR family - - - 0.00000000000000000000000000000000000005393 151.0
TLS2_k127_510185_14 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000001463 148.0
TLS2_k127_510185_15 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000008404 145.0
TLS2_k127_510185_16 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.0000000000000000000000000000896 123.0
TLS2_k127_510185_17 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000689 112.0
TLS2_k127_510185_18 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase - - - 0.00000000000000000000001028 107.0
TLS2_k127_510185_19 Non-essential cell division protein that could be required for efficient cell constriction - - - 0.000000001223 70.0
TLS2_k127_510185_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 295.0
TLS2_k127_510185_20 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K06034 - 4.1.1.79 0.000000002604 67.0
TLS2_k127_510185_3 ATPases associated with a variety of cellular activities K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003436 284.0
TLS2_k127_510185_4 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002823 281.0
TLS2_k127_510185_5 Aldo Keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000068 274.0
TLS2_k127_510185_6 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000001418 277.0
TLS2_k127_510185_7 NMT1/THI5 like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000034 268.0
TLS2_k127_510185_8 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008131 256.0
TLS2_k127_510185_9 PFAM amidohydrolase 2 K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000008082 235.0
TLS2_k127_5108814_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 1.458e-314 985.0
TLS2_k127_5108814_1 adenosylhomocysteinase activity K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000714 525.0
TLS2_k127_5108814_10 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.0000000000000000000000005065 116.0
TLS2_k127_5108814_11 - - - - 0.00000000001879 70.0
TLS2_k127_5108814_12 Trm112p-like protein K09791 - - 0.0000000003384 66.0
TLS2_k127_5108814_13 PFAM Phosphoribosyl transferase domain - - - 0.000000003597 65.0
TLS2_k127_5108814_14 Protein of unknown function (DUF3499) - - - 0.00000001095 61.0
TLS2_k127_5108814_15 - - - - 0.0000001914 63.0
TLS2_k127_5108814_16 - - - - 0.0001825 54.0
TLS2_k127_5108814_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01840 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008897 460.0
TLS2_k127_5108814_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 376.0
TLS2_k127_5108814_4 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004623 365.0
TLS2_k127_5108814_5 ATPases associated with a variety of cellular activities K09812 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 312.0
TLS2_k127_5108814_6 Sugar isomerase (SIS) K15916 - 5.3.1.8,5.3.1.9 0.000000000000000000000000000000000000000000000000000003661 203.0
TLS2_k127_5108814_7 Response regulator receiver K02479 - - 0.0000000000000000000000000000000000000000000002896 175.0
TLS2_k127_5108814_8 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000001891 169.0
TLS2_k127_5108814_9 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000001008 160.0
TLS2_k127_5144063_0 Proline racemase K01777 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016855,GO:0018112,GO:0019752,GO:0036361,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0050346,GO:0071704,GO:1901564 5.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006683 426.0
TLS2_k127_5144063_1 ATPase activity K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003441 265.0
TLS2_k127_5144063_2 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000001865 198.0
TLS2_k127_5144063_3 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis - - - 0.0000000000000000000000000000000000002267 158.0
TLS2_k127_5144063_4 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000001042 149.0
TLS2_k127_5144063_5 Polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000000007 142.0
TLS2_k127_5144063_6 Acetyltransferase (GNAT) domain - - - 0.000004507 58.0
TLS2_k127_5144063_8 Acetyltransferase (GNAT) domain - - - 0.0000178 56.0
TLS2_k127_5251275_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 408.0
TLS2_k127_5251275_1 Domain of unknown function (DUF4389) - - - 0.0000000000000000000000000000000000000000000000000002252 185.0
TLS2_k127_5251275_2 Sporulation and spore germination - - - 0.00000000000000000000000000000000000000000000005889 181.0
TLS2_k127_5320130_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 1.946e-219 691.0
TLS2_k127_5320130_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009729 395.0
TLS2_k127_5320130_2 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000001747 269.0
TLS2_k127_5320130_3 F420-0:Gamma-glutamyl ligase K12234 GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000005139 250.0
TLS2_k127_5320130_4 LytR cell envelope-related transcriptional attenuator - - - 0.00000000000000000000000000000000000000000000001799 188.0
TLS2_k127_5320130_5 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000004251 108.0
TLS2_k127_5320130_6 Biotin-(Acetyl-CoA carboxylase) ligase K03524 - 6.3.4.15 0.0000000000000000005181 95.0
TLS2_k127_5320130_7 Glycosyltransferase like family 2 - - - 0.00000000000000003633 94.0
TLS2_k127_5471505_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.531e-256 800.0
TLS2_k127_5471505_1 Domain of unknown function (DUF4118) K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003268 520.0
TLS2_k127_5471505_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000000000000000000000002458 187.0
TLS2_k127_5533473_0 PFAM Glycoside hydrolase family 65, central catalytic - - - 3.866e-308 962.0
TLS2_k127_5533473_1 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 3.227e-283 895.0
TLS2_k127_5533473_10 coenzyme F420 hydrogenase activity K18007 - 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 381.0
TLS2_k127_5533473_11 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000775 336.0
TLS2_k127_5533473_12 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005027 321.0
TLS2_k127_5533473_13 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006478 321.0
TLS2_k127_5533473_14 SPTR C1WI92 Carbohydrate ABC transporter membrane protein 2, CUT1 family K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003106 259.0
TLS2_k127_5533473_15 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001569 255.0
TLS2_k127_5533473_16 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000001577 245.0
TLS2_k127_5533473_17 Lao ao transport system K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000004203 227.0
TLS2_k127_5533473_18 Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK) K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000001515 229.0
TLS2_k127_5533473_19 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01911 - 6.2.1.26 0.00000000000000000000000000000000000000000000000000000000000002014 230.0
TLS2_k127_5533473_2 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 7.079e-194 613.0
TLS2_k127_5533473_20 - - - - 0.000000000000000000000000000000000000000000000000000000000006769 228.0
TLS2_k127_5533473_21 NmrA family - - - 0.00000000000000000000000000000000000000000000000000000006946 204.0
TLS2_k127_5533473_22 helix_turn _helix lactose operon repressor - - - 0.00000000000000000000000000000000000000000000000000003186 201.0
TLS2_k127_5533473_23 META domain - - - 0.00000000000000000000000000000000000000000000000003141 189.0
TLS2_k127_5533473_24 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000005313 180.0
TLS2_k127_5533473_25 Required for disulfide bond formation in some proteins K03611 - - 0.000000000000000000000000000000000004674 144.0
TLS2_k127_5533473_26 O-methyltransferase - - - 0.00000000000000000000000000000000002473 144.0
TLS2_k127_5533473_27 SpoIID LytB domain protein K06381 - - 0.00000000000000000000000000000000003466 154.0
TLS2_k127_5533473_28 membrane - - - 0.00000000000000000000000000000007862 131.0
TLS2_k127_5533473_29 Redoxin - - - 0.0000000000000000000000000000003633 132.0
TLS2_k127_5533473_3 Nickel-dependent hydrogenase K00436 - 1.12.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 591.0
TLS2_k127_5533473_30 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.000000000000000000000000004597 119.0
TLS2_k127_5533473_31 Hydrogenase maturation protease - - - 0.000000000000000000000001015 116.0
TLS2_k127_5533473_32 translation release factor activity K02835,K15034 - - 0.0000000000000000000003947 101.0
TLS2_k127_5533473_33 Domain of unknown function (DUF1918) - - - 0.00000000000000002124 83.0
TLS2_k127_5533473_34 NifU-like domain - - - 0.0000000000000003647 83.0
TLS2_k127_5533473_35 Peptidase family M23 - - - 0.000000000000002531 84.0
TLS2_k127_5533473_36 - - - - 0.0000000004263 67.0
TLS2_k127_5533473_37 hydrogenase assembly chaperone HypC HupF K04653 - - 0.000000004499 61.0
TLS2_k127_5533473_38 Methyltransferase - - - 0.00008038 53.0
TLS2_k127_5533473_39 Polysaccharide biosynthesis protein - - - 0.0001105 50.0
TLS2_k127_5533473_4 COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component K09014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 547.0
TLS2_k127_5533473_5 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000709 512.0
TLS2_k127_5533473_6 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 498.0
TLS2_k127_5533473_7 Aldo/keto reductase family K16950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 483.0
TLS2_k127_5533473_8 Belongs to the EPSP synthase family. MurA subfamily K00790 GO:0008150,GO:0040007 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 437.0
TLS2_k127_5533473_9 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008034 409.0
TLS2_k127_5656161_0 pilus assembly protein ATPase CpaF K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007178 564.0
TLS2_k127_5656161_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 541.0
TLS2_k127_5656161_2 in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats K02945 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 466.0
TLS2_k127_5656161_3 Type II secretion system (T2SS), protein F K12510 - - 0.000000000000000000000000000000000000000000000000000000000000002469 243.0
TLS2_k127_5656161_4 Type II secretion system (T2SS), protein F K12511 - - 0.00000000000000000000000000000000000000000000000000000000000001911 229.0
TLS2_k127_5656161_5 NUBPL iron-transfer P-loop NTPase K02282 - - 0.0000000000000000000000000000000000000000000000000000007621 207.0
TLS2_k127_5656161_6 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000004441 150.0
TLS2_k127_5656161_7 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.0000001562 63.0
TLS2_k127_5691874_0 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 508.0
TLS2_k127_5691874_1 Belongs to the RtcB family K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004089 506.0
TLS2_k127_5691874_10 Belongs to the SEDS family K03588 GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000336 303.0
TLS2_k127_5691874_11 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006401 261.0
TLS2_k127_5691874_12 (ABC) transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003094 256.0
TLS2_k127_5691874_13 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000001758 228.0
TLS2_k127_5691874_14 MFS_1 like family - - - 0.000000000000000000000000000000000000000000000000000000000000003567 232.0
TLS2_k127_5691874_15 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000002456 227.0
TLS2_k127_5691874_16 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K11991 - 3.5.4.1,3.5.4.33 0.00000000000000000000000000000000000000000000000000005541 190.0
TLS2_k127_5691874_17 Sigma factor PP2C-like phosphatases K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000006573 183.0
TLS2_k127_5691874_18 Aminoacyl-tRNA editing domain K19055 - - 0.000000000000000000000000000000000003396 142.0
TLS2_k127_5691874_19 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000001174 149.0
TLS2_k127_5691874_2 phosphoribosyltransferase K07100 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 495.0
TLS2_k127_5691874_20 translation initiation inhibitor yjgF family - - - 0.0000000000000000000000000002106 119.0
TLS2_k127_5691874_21 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000000003578 109.0
TLS2_k127_5691874_22 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000003947 114.0
TLS2_k127_5691874_23 - K09957 - - 0.00000000000000000001526 98.0
TLS2_k127_5691874_24 histone H2A K63-linked ubiquitination K02283 - - 0.0000000000000000003989 94.0
TLS2_k127_5691874_25 (FHA) domain - - - 0.00000000000000861 83.0
TLS2_k127_5691874_26 Endoribonuclease L-PSP - - - 0.00000000000002354 79.0
TLS2_k127_5691874_27 Acetyltransferase (GNAT) family - - - 0.00000000002712 74.0
TLS2_k127_5691874_28 Archease protein family (MTH1598/TM1083) - - - 0.0000000001518 70.0
TLS2_k127_5691874_29 - - - - 0.000000006119 60.0
TLS2_k127_5691874_3 PFAM regulatory protein LuxR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 443.0
TLS2_k127_5691874_31 Involved in cell division - - - 0.0001516 48.0
TLS2_k127_5691874_4 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 430.0
TLS2_k127_5691874_5 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004757 410.0
TLS2_k127_5691874_6 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 407.0
TLS2_k127_5691874_7 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 354.0
TLS2_k127_5691874_8 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 354.0
TLS2_k127_5691874_9 Penicillin binding protein transpeptidase domain K05364 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000434 359.0
TLS2_k127_5700997_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 6.2.1.1 4.176e-282 879.0
TLS2_k127_5700997_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 4.933e-239 761.0
TLS2_k127_5700997_10 metallopeptidase MepB K01405,K13726 GO:0000322,GO:0000323,GO:0000324,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005773,GO:0005794,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0012505,GO:0016787,GO:0019538,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0034641,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043603,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070011,GO:0070013,GO:0071704,GO:0140096,GO:1901564 3.4.24.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 491.0
TLS2_k127_5700997_11 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009633 448.0
TLS2_k127_5700997_12 Amidohydrolase family K01466 - 3.5.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009836 434.0
TLS2_k127_5700997_13 Adenosine/AMP deaminase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007799 427.0
TLS2_k127_5700997_14 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00850,K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 426.0
TLS2_k127_5700997_15 Belongs to the allantoicase family K01477 - 3.5.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008287 413.0
TLS2_k127_5700997_16 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 392.0
TLS2_k127_5700997_17 Winged helix DNA-binding domain K09927 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003078 396.0
TLS2_k127_5700997_18 Belongs to the sigma-70 factor family K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 382.0
TLS2_k127_5700997_19 Aminotransferase class-V K04127 - 5.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000095 351.0
TLS2_k127_5700997_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K12954,K12956,K17686,K21887 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009405,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0042221,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0050896,GO:0051704,GO:0071944 3.6.3.4,3.6.3.54 1.183e-216 694.0
TLS2_k127_5700997_20 Belongs to the SAICAR synthetase family K01923,K01945 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006446 339.0
TLS2_k127_5700997_21 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004324 290.0
TLS2_k127_5700997_22 Phosphoribosylformylglycinamidine cyclo-ligase K01933 GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016882,GO:0044424,GO:0044444,GO:0044464 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001952 270.0
TLS2_k127_5700997_23 thiolester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001111 260.0
TLS2_k127_5700997_24 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000002154 248.0
TLS2_k127_5700997_25 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.00000000000000000000000000000000000000000000000000000000000007297 225.0
TLS2_k127_5700997_26 metal-dependent hydrolase with the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000002904 221.0
TLS2_k127_5700997_27 CO dehydrogenase flavoprotein C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000008997 215.0
TLS2_k127_5700997_28 PAC2 family - - - 0.000000000000000000000000000000000000000000000000000000000413 212.0
TLS2_k127_5700997_29 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000001595 210.0
TLS2_k127_5700997_3 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 2.597e-216 679.0
TLS2_k127_5700997_30 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000009356 207.0
TLS2_k127_5700997_31 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000003118 189.0
TLS2_k127_5700997_32 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000009881 183.0
TLS2_k127_5700997_33 isoleucine patch - - - 0.0000000000000000000000000000000000000000000004596 171.0
TLS2_k127_5700997_34 BON domain - - - 0.0000000000000000000000000000000000000006364 159.0
TLS2_k127_5700997_35 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000001807 147.0
TLS2_k127_5700997_36 Protein of unknown function (DUF456) K09793 - - 0.000000000000000000000000000000258 131.0
TLS2_k127_5700997_37 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.000000000000000000000000000007618 122.0
TLS2_k127_5700997_38 Short repeat of unknown function (DUF308) - - - 0.0000000000000000000000007971 111.0
TLS2_k127_5700997_39 PFAM Cell envelope-related transcriptional attenuator - - - 0.000000000000000000000002127 117.0
TLS2_k127_5700997_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 5.273e-213 686.0
TLS2_k127_5700997_40 Thioesterase superfamily K02614 - - 0.00000000000000000001655 96.0
TLS2_k127_5700997_41 amine dehydrogenase activity - - - 0.0000000000000000228 95.0
TLS2_k127_5700997_42 - - - - 0.00000000000000007562 90.0
TLS2_k127_5700997_43 - - - - 0.000000000000000114 90.0
TLS2_k127_5700997_44 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000002385 83.0
TLS2_k127_5700997_45 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.0000000000005784 74.0
TLS2_k127_5700997_46 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000007321 74.0
TLS2_k127_5700997_47 Heavy-metal-associated domain K07213 - - 0.0000000000125 68.0
TLS2_k127_5700997_49 - - - - 0.000001061 57.0
TLS2_k127_5700997_5 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006509 594.0
TLS2_k127_5700997_50 integral membrane protein - - - 0.0001171 52.0
TLS2_k127_5700997_6 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 557.0
TLS2_k127_5700997_7 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007268 565.0
TLS2_k127_5700997_8 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 518.0
TLS2_k127_5700997_9 Belongs to the HpcH HpaI aldolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 497.0
TLS2_k127_5728782_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.125e-261 815.0
TLS2_k127_5728782_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000374 448.0
TLS2_k127_5728782_10 imidazolonepropionase activity K01468 - 3.5.2.7 0.0000000000000000000000000000000004995 152.0
TLS2_k127_5728782_11 - - - - 0.000000000000000000000001776 115.0
TLS2_k127_5728782_12 - - - - 0.000000000000000001778 91.0
TLS2_k127_5728782_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 301.0
TLS2_k127_5728782_3 Arginase family - - - 0.0000000000000000000000000000000000000000000000000000006234 206.0
TLS2_k127_5728782_4 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000000001398 182.0
TLS2_k127_5728782_5 Belongs to the peptidase S41A family K03797 GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016787,GO:0019538,GO:0023052,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.102 0.000000000000000000000000000000000000000000008587 181.0
TLS2_k127_5728782_6 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - 0.0000000000000000000000000000000000000000007324 168.0
TLS2_k127_5728782_7 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000005249 168.0
TLS2_k127_5728782_8 Thioesterase superfamily - - - 0.000000000000000000000000000000000001687 142.0
TLS2_k127_5728782_9 ABC-2 family transporter protein K09694 - - 0.000000000000000000000000000000000006912 138.0
TLS2_k127_5744729_0 ABC transporter related K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 567.0
TLS2_k127_5744729_1 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 539.0
TLS2_k127_5744729_10 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000452 355.0
TLS2_k127_5744729_11 ABC transporter substrate-binding protein PnrA-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 351.0
TLS2_k127_5744729_12 Amino acid amide ABC transporter ATP-binding protein 1, HAAT family K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 335.0
TLS2_k127_5744729_13 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 294.0
TLS2_k127_5744729_14 Ion channel K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005342 292.0
TLS2_k127_5744729_15 Branched-chain amino acid transport K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007387 267.0
TLS2_k127_5744729_16 Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process K07067 - 2.7.7.85 0.00000000000000000000000000000000000000000000000000000000000000000000005625 252.0
TLS2_k127_5744729_17 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000001607 242.0
TLS2_k127_5744729_18 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000001314 228.0
TLS2_k127_5744729_19 Threonyl alanyl tRNA synthetase SAD K07050 - - 0.00000000000000000000000000000000000000000000000000000000000000002197 232.0
TLS2_k127_5744729_2 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007397 506.0
TLS2_k127_5744729_20 queuosine salvage K09125 - - 0.0000000000000000000000000000000000000000000000000000000000000002279 226.0
TLS2_k127_5744729_21 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.000000000000000000000000000000000000002132 156.0
TLS2_k127_5744729_22 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.000000000000000000000000000000000000005305 154.0
TLS2_k127_5744729_23 CarD family transcriptional regulator K07736 GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496 - 0.00000000000000000000000000000000002543 141.0
TLS2_k127_5744729_24 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000003968 137.0
TLS2_k127_5744729_25 Universal stress protein family - - - 0.0000000000000000000000000000007146 127.0
TLS2_k127_5744729_26 AI-2E family transporter - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000000000000000000000001175 136.0
TLS2_k127_5744729_27 Ion transport protein K10716 - - 0.0000000000000000000000001253 116.0
TLS2_k127_5744729_28 - - - - 0.00000000000001597 78.0
TLS2_k127_5744729_29 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.000000000000452 79.0
TLS2_k127_5744729_3 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 436.0
TLS2_k127_5744729_30 Protein of unknown function (DUF3263) - - - 0.000000002043 62.0
TLS2_k127_5744729_31 PFAM Forkhead-associated protein - - - 0.00006569 54.0
TLS2_k127_5744729_32 Colicin V production protein K03558 - - 0.000452 51.0
TLS2_k127_5744729_33 LytR cell envelope-related transcriptional attenuator - - - 0.0005396 50.0
TLS2_k127_5744729_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 430.0
TLS2_k127_5744729_5 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 429.0
TLS2_k127_5744729_6 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003913 424.0
TLS2_k127_5744729_7 KaiC K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004796 381.0
TLS2_k127_5744729_8 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 382.0
TLS2_k127_5744729_9 Belongs to the long-chain O-acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 376.0
TLS2_k127_5796522_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 2.334e-289 913.0
TLS2_k127_5796522_1 ATPases associated with a variety of cellular activities K02056,K10441 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 568.0
TLS2_k127_5796522_10 Branched-chain amino acid transport system / permease component K10440,K17209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 326.0
TLS2_k127_5796522_11 Belongs to the GHMP kinase family K00849 - 2.7.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 311.0
TLS2_k127_5796522_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005699 259.0
TLS2_k127_5796522_13 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000198 254.0
TLS2_k127_5796522_14 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000626 256.0
TLS2_k127_5796522_15 DeoR C terminal sensor domain - - - 0.00000000000000000000000000000000000000000000000000000000000000004124 232.0
TLS2_k127_5796522_16 Belongs to the arylamine N-acetyltransferase family K00675,K15466 - 2.3.1.118 0.00000000000000000000000000000000000000000000000000000004624 205.0
TLS2_k127_5796522_17 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000001811 206.0
TLS2_k127_5796522_18 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000004289 183.0
TLS2_k127_5796522_19 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000000008199 196.0
TLS2_k127_5796522_2 inositol 2-dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 443.0
TLS2_k127_5796522_20 domain, Protein K07228 - - 0.00000000000000000000000000000000000000000000002288 174.0
TLS2_k127_5796522_21 uridine kinase - - - 0.0000000000000000000000000000000000000000000015 175.0
TLS2_k127_5796522_22 Belongs to the P(II) protein family K04752 - - 0.00000000000000000000000000000000000000007099 156.0
TLS2_k127_5796522_23 Short-chain Dehydrogenase reductase - - - 0.00000000000000000000000000000000000001602 149.0
TLS2_k127_5796522_24 Histidine kinase - - - 0.00000000000000000000000000009479 133.0
TLS2_k127_5796522_25 phosphatase activity K07025 - - 0.00000000000000000000000000597 118.0
TLS2_k127_5796522_26 calcium- and calmodulin-responsive adenylate cyclase activity K07114,K20276 - - 0.000000000000000000000002258 121.0
TLS2_k127_5796522_28 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000219 98.0
TLS2_k127_5796522_29 Belongs to the universal stress protein A family - - - 0.0000000000000000003705 96.0
TLS2_k127_5796522_3 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 435.0
TLS2_k127_5796522_30 DsrE/DsrF-like family - - - 0.00000000000005462 73.0
TLS2_k127_5796522_31 Metallo-beta-lactamase superfamily - - - 0.000000003365 65.0
TLS2_k127_5796522_32 RNA polymerase, sigma-24 subunit, ECF subfamily K03088 - - 0.000008697 50.0
TLS2_k127_5796522_33 - - - - 0.00003851 56.0
TLS2_k127_5796522_34 membrane protein (DUF2078) K08982 - - 0.0001999 50.0
TLS2_k127_5796522_4 Periplasmic binding protein domain K10439 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 422.0
TLS2_k127_5796522_5 Phenazine biosynthesis protein PhzF - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 409.0
TLS2_k127_5796522_6 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 414.0
TLS2_k127_5796522_7 PFAM sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 398.0
TLS2_k127_5796522_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 352.0
TLS2_k127_5796522_9 Belongs to the binding-protein-dependent transport system permease family K02057,K10440 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005776 333.0
TLS2_k127_5808_0 PFAM sodium calcium exchanger K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039 365.0
TLS2_k127_5808_1 PFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000000000001644 220.0
TLS2_k127_5808_2 LysM domain K03642,K03791,K22278 - 3.5.1.104 0.00000003659 65.0
TLS2_k127_5911655_0 Molybdopterin oxidoreductase K00123 - 1.17.1.9 2.01e-236 741.0
TLS2_k127_5911655_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 8.874e-227 719.0
TLS2_k127_5911655_10 CoA-transferase family III K18702 - 2.8.3.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000657 327.0
TLS2_k127_5911655_11 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 321.0
TLS2_k127_5911655_12 nitric oxide dioxygenase activity K00528,K05784 GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000036 303.0
TLS2_k127_5911655_13 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 293.0
TLS2_k127_5911655_14 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002786 285.0
TLS2_k127_5911655_15 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001791 275.0
TLS2_k127_5911655_16 Pfam Class II Aldolase and Adducin N-terminal domain K03077 - 5.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000001648 254.0
TLS2_k127_5911655_17 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008758 248.0
TLS2_k127_5911655_18 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000093 239.0
TLS2_k127_5911655_19 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000009379 243.0
TLS2_k127_5911655_2 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 4.541e-226 715.0
TLS2_k127_5911655_20 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000005891 242.0
TLS2_k127_5911655_21 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000001964 231.0
TLS2_k127_5911655_22 Mandelate racemase muconate lactonizing enzyme K01781,K20023 - 4.2.1.156,4.2.1.42,5.1.2.2 0.00000000000000000000000000000000000000000000000000000000001249 224.0
TLS2_k127_5911655_23 oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000003032 218.0
TLS2_k127_5911655_24 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000005464 199.0
TLS2_k127_5911655_25 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000007293 196.0
TLS2_k127_5911655_26 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000303 193.0
TLS2_k127_5911655_27 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01856,K19802 - 5.1.1.20,5.5.1.1 0.00000000000000000000000000000000000000000481 179.0
TLS2_k127_5911655_28 Zn peptidase - - - 0.0000000000000000000000000000000000000006685 165.0
TLS2_k127_5911655_29 YCII-related domain - - - 0.000000000000000000000000000000000000008367 147.0
TLS2_k127_5911655_3 FGGY family of carbohydrate kinases, N-terminal domain K00853 - 2.7.1.16 7.006e-211 670.0
TLS2_k127_5911655_30 Domain of unknown function (DUF4380) - - - 0.000000000000000000000000000000003826 139.0
TLS2_k127_5911655_31 Luciferase-like monooxygenase - - - 0.000000000000000000000000000001106 129.0
TLS2_k127_5911655_32 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919,K02528,K16924 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 2.1.1.182,2.7.1.148 0.00000000000000000000000000007593 126.0
TLS2_k127_5911655_33 Competence-damaged protein K03742 - 3.5.1.42 0.0000000000000000000000000002581 126.0
TLS2_k127_5911655_34 Transcriptional regulator - - - 0.0000000000000000000000000113 114.0
TLS2_k127_5911655_35 Molybdopterin oxidoreductase K00123 - 1.17.1.9 0.00000000000000000000000308 104.0
TLS2_k127_5911655_36 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity - - - 0.0000000000000000000001426 109.0
TLS2_k127_5911655_37 AbrB family K06284 - - 0.000000000000000004561 87.0
TLS2_k127_5911655_38 - - - - 0.0000000000000004355 88.0
TLS2_k127_5911655_39 dehydratase - - - 0.0000000000001252 82.0
TLS2_k127_5911655_4 L-arabinose isomerase K01804 - 5.3.1.4 4.485e-208 659.0
TLS2_k127_5911655_40 Protein of unknown function (DUF2795) - - - 0.000000001652 62.0
TLS2_k127_5911655_41 pyridine nucleotide-disulfide oxidoreductase K00384 - 1.8.1.9 0.000004546 59.0
TLS2_k127_5911655_42 Uncharacterized ACR, COG1430 K09005 - - 0.0002089 49.0
TLS2_k127_5911655_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00122,K00335 - 1.17.1.9,1.6.5.3 1.042e-198 637.0
TLS2_k127_5911655_6 Class II release factor RF3, C-terminal domain K02837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006175 593.0
TLS2_k127_5911655_7 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 549.0
TLS2_k127_5911655_8 2Fe-2S iron-sulfur cluster binding domain K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 390.0
TLS2_k127_5911655_9 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 345.0
TLS2_k127_5923243_0 - - - - 0.000000000000000000000000000000000000000000000000000000002205 208.0
TLS2_k127_5923243_1 Cache domain K11527 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000007303 207.0
TLS2_k127_5923243_10 Ribbon-helix-helix protein, copG family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000005052 59.0
TLS2_k127_5923243_11 - - - - 0.000003302 57.0
TLS2_k127_5923243_12 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.00001507 49.0
TLS2_k127_5923243_13 Virulence protein RhuM family - - - 0.0002209 47.0
TLS2_k127_5923243_14 regulation of methylation-dependent chromatin silencing K07454 - - 0.0004424 45.0
TLS2_k127_5923243_2 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000004137 173.0
TLS2_k127_5923243_3 Toxic component of a toxin-antitoxin (TA) module K07171 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000009025 151.0
TLS2_k127_5923243_4 PemK-like, MazF-like toxin of type II toxin-antitoxin system - - - 0.00000000000000000000000000000001046 130.0
TLS2_k127_5923243_5 - - - - 0.00000000000000000000000000003221 131.0
TLS2_k127_5923243_6 Domain of unknown function (DUF4160) - - - 0.000000000000000000000000006593 111.0
TLS2_k127_5923243_7 Protein of unknown function (DUF2442) - - - 0.000000000000004123 78.0
TLS2_k127_5923243_8 COGs COG1487 nucleic acid-binding protein contains PIN domain - - - 0.0000000000002869 76.0
TLS2_k127_5923243_9 - - - - 0.00000000000271 74.0
TLS2_k127_5946530_0 PFAM ABC transporter related K01990,K19340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 299.0
TLS2_k127_5946530_1 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000001484 239.0
TLS2_k127_5946530_2 NPCBM-associated, NEW3 domain of alpha-galactosidase - - - 0.0000000000000000000000000000000000000000000000000001024 202.0
TLS2_k127_5946530_3 protein import K01179 - 3.2.1.4 0.00002424 55.0
TLS2_k127_5946530_4 protein import K01179 - 3.2.1.4 0.0003048 51.0
TLS2_k127_5951430_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564 2.7.4.1 7.714e-240 759.0
TLS2_k127_5951430_1 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 5.811e-204 647.0
TLS2_k127_5951430_10 PBP superfamily domain K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 377.0
TLS2_k127_5951430_11 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 378.0
TLS2_k127_5951430_12 Elongation factor SelB, winged helix K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 381.0
TLS2_k127_5951430_13 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 332.0
TLS2_k127_5951430_14 NmrA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 328.0
TLS2_k127_5951430_15 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009825 336.0
TLS2_k127_5951430_16 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 299.0
TLS2_k127_5951430_17 response regulator K07776 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001614 263.0
TLS2_k127_5951430_18 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000001562 255.0
TLS2_k127_5951430_19 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000902 216.0
TLS2_k127_5951430_2 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 575.0
TLS2_k127_5951430_20 ABC transporter K02029,K02030 - - 0.00000000000000000000000000000000000000000000000000000000006071 209.0
TLS2_k127_5951430_21 PFAM Extracellular solute-binding protein, family 3 K02030 - - 0.000000000000000000000000000000000000000000000000000000004291 211.0
TLS2_k127_5951430_22 Histidine kinase K07768 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564 2.7.13.3 0.00000000000000000000000000000000000000000000000000000004158 215.0
TLS2_k127_5951430_23 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000001194 204.0
TLS2_k127_5951430_24 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000008949 193.0
TLS2_k127_5951430_25 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000881 193.0
TLS2_k127_5951430_26 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000005054 181.0
TLS2_k127_5951430_27 Thiopurine S-methyltransferase (TPMT) - - - 0.000000000000000000000000000000000000000000001067 174.0
TLS2_k127_5951430_28 protein histidine kinase activity K03320 - - 0.00000000000000000000000000000000000000000002615 178.0
TLS2_k127_5951430_29 heme binding K21471,K21472 - - 0.000000000000000000000000000000000000000098 168.0
TLS2_k127_5951430_3 Monoamine oxidase K00274 - 1.4.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 561.0
TLS2_k127_5951430_30 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000001108 161.0
TLS2_k127_5951430_31 Iron-sulphur cluster biosynthesis K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564 - 0.00000000000000000000000000000000000001578 147.0
TLS2_k127_5951430_32 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000006805 152.0
TLS2_k127_5951430_33 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000006478 139.0
TLS2_k127_5951430_34 NUDIX domain - - - 0.0000000000000000000000000001454 123.0
TLS2_k127_5951430_35 - - - - 0.000000000000000000000000000499 118.0
TLS2_k127_5951430_36 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.00000000000000000000001158 102.0
TLS2_k127_5951430_37 Sigma-70, region 4 - - - 0.0000000000000000000003291 107.0
TLS2_k127_5951430_38 Transcription factor WhiB K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000001993 94.0
TLS2_k127_5951430_39 RDD family - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000002364 94.0
TLS2_k127_5951430_4 glutamine synthetase K01915 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005166 547.0
TLS2_k127_5951430_40 Flavin containing amine oxidoreductase - - - 0.0000000000000000258 84.0
TLS2_k127_5951430_41 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000468 89.0
TLS2_k127_5951430_42 phosphorelay signal transduction system - - - 0.000000000000000265 83.0
TLS2_k127_5951430_43 Flavin containing amine oxidoreductase - - - 0.00000002369 57.0
TLS2_k127_5951430_45 translation initiation factor activity K08930 - - 0.0001759 53.0
TLS2_k127_5951430_5 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 437.0
TLS2_k127_5951430_6 Alpha/beta-hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 427.0
TLS2_k127_5951430_7 binding-protein-dependent transport systems inner membrane component K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009484 400.0
TLS2_k127_5951430_8 cystathione gamma lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 404.0
TLS2_k127_5951430_9 Binding-protein-dependent transport system inner membrane component K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 388.0
TLS2_k127_6015262_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.082e-222 702.0
TLS2_k127_6015262_1 Proteasomal ATPase OB/ID domain K13527 - - 1.316e-219 697.0
TLS2_k127_6015262_10 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 418.0
TLS2_k127_6015262_11 Epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 400.0
TLS2_k127_6015262_12 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008135 340.0
TLS2_k127_6015262_13 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 298.0
TLS2_k127_6015262_14 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001497 283.0
TLS2_k127_6015262_15 May be involved in recombinational repair of damaged DNA K03631 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001535 295.0
TLS2_k127_6015262_16 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005834 285.0
TLS2_k127_6015262_17 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005517 282.0
TLS2_k127_6015262_18 Peptidase dimerisation domain K01439,K05831 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000345 280.0
TLS2_k127_6015262_19 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000006098 269.0
TLS2_k127_6015262_2 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K13571 - 6.3.1.19 3.227e-219 687.0
TLS2_k127_6015262_20 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002348 263.0
TLS2_k127_6015262_21 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000005114 262.0
TLS2_k127_6015262_22 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000002388 259.0
TLS2_k127_6015262_23 integrase domain protein SAM domain protein K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003394 252.0
TLS2_k127_6015262_24 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.0000000000000000000000000000000000000000000000000000000000000000000006296 250.0
TLS2_k127_6015262_25 RNA pseudouridylate synthase K06178,K06183 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000004333 241.0
TLS2_k127_6015262_26 PFAM extracellular solute-binding protein, family 5 - - - 0.000000000000000000000000000000000000000000000000000000000000001747 240.0
TLS2_k127_6015262_27 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.0000000000000000000000000000000000000000000000000000000000001739 217.0
TLS2_k127_6015262_28 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000008417 215.0
TLS2_k127_6015262_29 Ribosomal RNA methyltransferase RrmJ FtsJ K06442 GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000001996 215.0
TLS2_k127_6015262_3 DSHCT K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 4.422e-208 675.0
TLS2_k127_6015262_30 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000000002082 209.0
TLS2_k127_6015262_31 - - - - 0.000000000000000000000000000000000000000000000000000000001903 201.0
TLS2_k127_6015262_32 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000004615 207.0
TLS2_k127_6015262_33 hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000174 207.0
TLS2_k127_6015262_34 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000000002451 188.0
TLS2_k127_6015262_35 Belongs to the UPF0301 (AlgH) family K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000007393 185.0
TLS2_k127_6015262_36 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000009736 190.0
TLS2_k127_6015262_37 transcriptional regulator K13573 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000003095 188.0
TLS2_k127_6015262_38 Thioredoxin K00384,K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.9 0.0000000000000000000000000000000000000000000000004884 180.0
TLS2_k127_6015262_39 PFAM Uncharacterised ACR, COG1259 K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000051 180.0
TLS2_k127_6015262_4 Dehydrogenase K00004,K00060,K08322 GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0030246,GO:0042221,GO:0044238,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701 1.1.1.103,1.1.1.303,1.1.1.380,1.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 530.0
TLS2_k127_6015262_40 YbaK prolyl-tRNA synthetase associated region - - - 0.000000000000000000000000000000000000000000000004476 178.0
TLS2_k127_6015262_41 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000000000000000000000000004257 174.0
TLS2_k127_6015262_42 Belongs to the peptidase S11 family K07258 GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.16.4 0.0000000000000000000000000000000000000000000001012 184.0
TLS2_k127_6015262_43 MOSC domain - - - 0.000000000000000000000000000000000000000000001137 180.0
TLS2_k127_6015262_44 PFAM MerR family regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000001692 173.0
TLS2_k127_6015262_45 - - - - 0.0000000000000000000000000000000000000000005943 158.0
TLS2_k127_6015262_46 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.000000000000000000000000000000000000000003492 163.0
TLS2_k127_6015262_47 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000009979 154.0
TLS2_k127_6015262_48 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000256 157.0
TLS2_k127_6015262_49 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000002934 162.0
TLS2_k127_6015262_5 Pup-ligase protein K20814 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 525.0
TLS2_k127_6015262_50 PFAM Haloacid dehalogenase domain protein hydrolase K01101 - 3.1.3.41 0.000000000000000000000000000000000000003663 156.0
TLS2_k127_6015262_51 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000009012 149.0
TLS2_k127_6015262_52 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000001585 151.0
TLS2_k127_6015262_53 SMART ATP-binding region ATPase domain protein K03320 - - 0.0000000000000000000000000000000000001228 154.0
TLS2_k127_6015262_54 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000008198 147.0
TLS2_k127_6015262_55 WYL domain K13572,K13573 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000004868 148.0
TLS2_k127_6015262_56 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000005463 143.0
TLS2_k127_6015262_57 - - - - 0.00000000000000000000000000000000009123 136.0
TLS2_k127_6015262_58 4Fe-4S single cluster domain of Ferredoxin I K05337 - - 0.0000000000000000000000000000000003627 138.0
TLS2_k127_6015262_59 Cytidylate kinase-like family K00760 - 2.4.2.8 0.0000000000000000000000000000000004307 143.0
TLS2_k127_6015262_6 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 447.0
TLS2_k127_6015262_60 Transmembrane secretion effector - - - 0.000000000000000000000000000000009187 145.0
TLS2_k127_6015262_61 Protein of unknown function DUF126 K09128 - - 0.00000000000000000000000000008168 123.0
TLS2_k127_6015262_62 zinc-ribbon domain - - - 0.0000000000000000000000001391 111.0
TLS2_k127_6015262_63 NUDIX domain - - - 0.000000000000000000000000188 110.0
TLS2_k127_6015262_64 the in vivo substrate is - - - 0.0000000000000000000000006588 116.0
TLS2_k127_6015262_65 - - - - 0.0000000000000000000005846 100.0
TLS2_k127_6015262_66 - - - - 0.000000000000000001711 85.0
TLS2_k127_6015262_67 ORF located using Blastx - - - 0.00000000000000002522 85.0
TLS2_k127_6015262_68 - - - - 0.0000000000000002073 80.0
TLS2_k127_6015262_69 Unextendable partial coding region - - - 0.000000000000000367 78.0
TLS2_k127_6015262_7 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01835,K01840 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003006 447.0
TLS2_k127_6015262_70 PFAM Pentapeptide repeats (8 copies) - - - 0.0000000000000009697 87.0
TLS2_k127_6015262_71 - - - - 0.000000000000001066 78.0
TLS2_k127_6015262_72 - - - - 0.000000000000001105 79.0
TLS2_k127_6015262_73 n-acetylmuramoyl-L-alanine amidase K01448 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 0.000000000000001944 87.0
TLS2_k127_6015262_74 - - - - 0.000000000002035 70.0
TLS2_k127_6015262_75 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000001059 70.0
TLS2_k127_6015262_76 - - - - 0.00000000002368 63.0
TLS2_k127_6015262_77 Evidence 5 No homology to any previously reported sequences - - - 0.00000000004031 75.0
TLS2_k127_6015262_78 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000002832 65.0
TLS2_k127_6015262_79 Acetyltransferase (GNAT) family - - - 0.000000001023 69.0
TLS2_k127_6015262_8 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 430.0
TLS2_k127_6015262_81 - - - - 0.00000000134 61.0
TLS2_k127_6015262_82 - - - - 0.000000001656 63.0
TLS2_k127_6015262_83 - - - - 0.00000000241 59.0
TLS2_k127_6015262_84 Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation K13570 - - 0.000000002799 60.0
TLS2_k127_6015262_85 - - - - 0.0000001831 55.0
TLS2_k127_6015262_86 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117 - - 0.000001808 57.0
TLS2_k127_6015262_88 - - - - 0.000007687 54.0
TLS2_k127_6015262_89 - - - - 0.00003188 47.0
TLS2_k127_6015262_9 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 427.0
TLS2_k127_6015262_90 - - - - 0.00008779 49.0
TLS2_k127_6015262_92 Major facilitator Superfamily - - - 0.0003546 51.0
TLS2_k127_6015262_93 PFAM Metal-dependent phosphohydrolase, HD - - - 0.0005655 50.0
TLS2_k127_6015262_94 - - - - 0.0006171 45.0
TLS2_k127_6109625_0 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007294 453.0
TLS2_k127_6109625_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000001388 227.0
TLS2_k127_6109625_2 PFAM Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000007603 208.0
TLS2_k127_6109625_3 BON domain - - - 0.0000000000000000000000000001005 123.0
TLS2_k127_6109625_4 PFAM HNH endonuclease - - - 0.00000000000000000000001398 114.0
TLS2_k127_6193788_0 alcohol dehydrogenase K00001 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 427.0
TLS2_k127_6193788_1 NMT1/THI5 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 357.0
TLS2_k127_6193788_2 AI-2E family transporter - - - 0.000000000000000000000000000000000000000247 162.0
TLS2_k127_6193788_3 FCD - - - 0.00000000000000000000000000000000000006092 153.0
TLS2_k127_65007_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1482.0
TLS2_k127_65007_1 Oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000086 615.0
TLS2_k127_65007_10 N-formylglutamate amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004603 263.0
TLS2_k127_65007_11 membrane K07149 - - 0.000000000000000000000000000000000000000000000000000000000001312 217.0
TLS2_k127_65007_12 Mo-co oxidoreductase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000005935 209.0
TLS2_k127_65007_13 L-asparaginase II - - - 0.0000000000000000000000000000000000000000000000000000002388 211.0
TLS2_k127_65007_14 DsrC like protein K11179 - - 0.000000000000000000000000000000000000001338 154.0
TLS2_k127_65007_15 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000000003534 139.0
TLS2_k127_65007_16 membrane transporter protein K07090 - - 0.000000000000000000000000000002564 130.0
TLS2_k127_65007_17 heme binding K21471,K21472 - - 0.000000000000000000000000000004368 135.0
TLS2_k127_65007_18 PFAM PspC domain protein K03973 - - 0.00000000000000000000000000007103 121.0
TLS2_k127_65007_19 - - - - 0.000000000000000000000001393 110.0
TLS2_k127_65007_2 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162,K21417 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 501.0
TLS2_k127_65007_20 Phosphate acyltransferases - - - 0.0000000000000000001144 99.0
TLS2_k127_65007_21 positive regulation of macromolecule biosynthetic process - - - 0.000000000000000002549 93.0
TLS2_k127_65007_22 Putative bacterial sensory transduction regulator - - - 0.000000000000000002628 90.0
TLS2_k127_65007_23 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000008422 89.0
TLS2_k127_65007_24 SnoaL-like polyketide cyclase - - - 0.00000000000000007296 86.0
TLS2_k127_65007_25 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.0000000000000002233 85.0
TLS2_k127_65007_26 Mo-molybdopterin cofactor metabolic process K03636,K21142 - 2.8.1.12 0.00000000002233 76.0
TLS2_k127_65007_27 - - - - 0.0000000006246 64.0
TLS2_k127_65007_28 Alpha/beta hydrolase family - - - 0.000000001981 68.0
TLS2_k127_65007_29 - - - - 0.000267 51.0
TLS2_k127_65007_3 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 425.0
TLS2_k127_65007_4 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 409.0
TLS2_k127_65007_5 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 364.0
TLS2_k127_65007_6 Alpha/beta hydrolase family K01563 - 3.8.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 319.0
TLS2_k127_65007_7 PFAM dehydrogenase, E1 component K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 295.0
TLS2_k127_65007_8 DUF1704 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000354 281.0
TLS2_k127_65007_9 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000225 267.0
TLS2_k127_6501508_0 Dihydrodipicolinate synthetase family - - - 0.00000000000000000000000000000000003066 145.0
TLS2_k127_6501508_1 TadE-like protein - - - 0.0000000009634 69.0
TLS2_k127_6501508_2 Putative Flp pilus-assembly TadE/G-like - - - 0.000000004584 62.0
TLS2_k127_6501508_3 Sterol carrier protein - - - 0.00000005296 59.0
TLS2_k127_6501508_4 TadE-like protein - - - 0.000000666 58.0
TLS2_k127_6706644_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008719 577.0
TLS2_k127_6706644_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 377.0
TLS2_k127_6706644_10 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000004438 71.0
TLS2_k127_6706644_11 XRE family K21498 - - 0.00003748 50.0
TLS2_k127_6706644_12 His Kinase A (phosphoacceptor) domain K07636,K07768 - 2.7.13.3 0.000132 48.0
TLS2_k127_6706644_2 transferase activity, transferring hexosyl groups - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0009058,GO:0009247,GO:0009405,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0020012,GO:0030682,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001329 293.0
TLS2_k127_6706644_3 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008604 289.0
TLS2_k127_6706644_4 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004531 278.0
TLS2_k127_6706644_5 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001307 229.0
TLS2_k127_6706644_6 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000003429 206.0
TLS2_k127_6706644_7 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000002219 163.0
TLS2_k127_6706644_8 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000004411 101.0
TLS2_k127_6706644_9 - - - - 0.00000000000000001553 95.0
TLS2_k127_6841051_0 malic enzyme K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 1.588e-255 808.0
TLS2_k127_6841051_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 3.355e-222 718.0
TLS2_k127_6841051_10 ROK family K00886 - 2.7.1.63 0.0000000000000000000000000000000000000000000000000000000000000000001848 239.0
TLS2_k127_6841051_11 Participates in transcription elongation, termination and antitermination K02601 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000007618 242.0
TLS2_k127_6841051_12 Transcriptional regulator PadR-like family K10947 - - 0.000000000000000000000000000000000000000000000000000000001649 201.0
TLS2_k127_6841051_13 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000003582 202.0
TLS2_k127_6841051_14 menaquinone-dependent protoporphyrinogen oxidase activity K00230 - 1.3.5.3 0.00000000000000000000000000000000000000000000000007124 182.0
TLS2_k127_6841051_15 Protein of unknown function (DUF1048) - - - 0.000000000000000000000000000000000000000000000001881 180.0
TLS2_k127_6841051_16 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000001393 170.0
TLS2_k127_6841051_17 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000002199 165.0
TLS2_k127_6841051_18 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000003259 138.0
TLS2_k127_6841051_19 - - - - 0.000000000000000000000000000000006963 133.0
TLS2_k127_6841051_2 ERAP1-like C-terminal domain K01256,K08776 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 606.0
TLS2_k127_6841051_20 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000006264 104.0
TLS2_k127_6841051_21 Ribosomal protein L33 K02913 - - 0.00000000000000000001635 91.0
TLS2_k127_6841051_22 translation elongation factor activity K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000002523 84.0
TLS2_k127_6841051_23 N-terminal half of MaoC dehydratase - - - 0.000000000009117 75.0
TLS2_k127_6841051_24 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000005622 67.0
TLS2_k127_6841051_3 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 558.0
TLS2_k127_6841051_4 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 432.0
TLS2_k127_6841051_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 419.0
TLS2_k127_6841051_6 Phosphoserine phosphatase K01079 GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004052 380.0
TLS2_k127_6841051_7 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007418 376.0
TLS2_k127_6841051_8 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 288.0
TLS2_k127_6841051_9 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006239 286.0
TLS2_k127_6858543_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0 1562.0
TLS2_k127_6858543_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 6.457e-302 940.0
TLS2_k127_6858543_2 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 3.052e-198 623.0
TLS2_k127_6858543_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 1.595e-196 617.0
TLS2_k127_6858543_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000567 208.0
TLS2_k127_6858543_5 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000007771 207.0
TLS2_k127_6902676_0 CoA binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000395 338.0
TLS2_k127_6902676_1 F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008717 244.0
TLS2_k127_6902676_2 Recombinase - - - 0.0000000000000000000000000004035 114.0
TLS2_k127_7046119_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1412.0
TLS2_k127_7046119_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 6.007e-215 676.0
TLS2_k127_7046119_10 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 296.0
TLS2_k127_7046119_11 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001261 270.0
TLS2_k127_7046119_12 Putative glycosyl hydrolase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008295 270.0
TLS2_k127_7046119_13 ATPases associated with a variety of cellular activities K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006101 255.0
TLS2_k127_7046119_14 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004113 245.0
TLS2_k127_7046119_15 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000001005 242.0
TLS2_k127_7046119_16 FeS assembly protein SufD K07033,K09015 GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136 - 0.00000000000000000000000000000000000000000000000000000000001715 222.0
TLS2_k127_7046119_17 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.00000000000000000000000000000000000000000000000000000003304 215.0
TLS2_k127_7046119_18 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000002049 184.0
TLS2_k127_7046119_19 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000005405 188.0
TLS2_k127_7046119_2 Acyl-CoA dehydrogenase N terminal - - - 1.722e-213 679.0
TLS2_k127_7046119_20 F420-dependent oxidoreductase K04091 - 1.14.14.5 0.00000000000000000000000000000000000000000001625 173.0
TLS2_k127_7046119_21 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000000001627 150.0
TLS2_k127_7046119_22 YbaK prolyl-tRNA synthetase associated region - - - 0.000000000000000000000000000000005292 134.0
TLS2_k127_7046119_23 response to oxidative stress - - - 0.00000000000000000000000000000001205 132.0
TLS2_k127_7046119_24 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000006366 110.0
TLS2_k127_7046119_25 Rieske 2Fe-2S K05710 - - 0.000000000000000000000001594 108.0
TLS2_k127_7046119_26 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000004741 98.0
TLS2_k127_7046119_27 hydrolase of the alpha beta superfamily K07018 - - 0.0000000000000001276 94.0
TLS2_k127_7046119_28 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000001308 78.0
TLS2_k127_7046119_29 - - - - 0.0000000000001412 79.0
TLS2_k127_7046119_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00140,K00823 - 1.2.1.18,1.2.1.27,2.6.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006938 569.0
TLS2_k127_7046119_30 SPTR Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein K07005 - - 0.00000001007 62.0
TLS2_k127_7046119_31 Transcriptional regulator K18939 - - 0.00000003577 62.0
TLS2_k127_7046119_4 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008023 526.0
TLS2_k127_7046119_5 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 452.0
TLS2_k127_7046119_6 TIGRFAM Dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 425.0
TLS2_k127_7046119_7 e3 binding domain K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 373.0
TLS2_k127_7046119_8 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 346.0
TLS2_k127_7046119_9 ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 306.0
TLS2_k127_7174592_0 FAD binding domain K21401 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 1.3.99.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 438.0
TLS2_k127_7174592_1 Cytochrome b/b6/petB K03891 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 397.0
TLS2_k127_7174592_10 Evidence 2b Function of strongly homologous gene - - - 0.00000000000000000000000000000006671 127.0
TLS2_k127_7174592_11 Cytochrome C and Quinol oxidase polypeptide I K00404 - 1.9.3.1 0.000000000000000000000002536 118.0
TLS2_k127_7174592_12 mRNA cleavage and polyadenylation factor CLP1 P-loop K06947 - - 0.000000000000000000006 104.0
TLS2_k127_7174592_13 peptidase inhibitor activity - - - 0.000000000006397 78.0
TLS2_k127_7174592_14 Cytochrome c - - - 0.00000002789 66.0
TLS2_k127_7174592_15 Cytochrome C oxidase, mono-heme subunit/FixO - - - 0.00000007878 64.0
TLS2_k127_7174592_16 Glutaredoxin-like domain (DUF836) - - - 0.0000003315 56.0
TLS2_k127_7174592_17 - - - - 0.0003054 51.0
TLS2_k127_7174592_18 - - - - 0.0007114 47.0
TLS2_k127_7174592_2 Cytochrome b(C-terminal)/b6/petD - - - 0.000000000000000000000000000000000000000000000000000000000002207 221.0
TLS2_k127_7174592_3 transferase activity, transferring alkyl or aryl (other than methyl) groups K22205 - - 0.00000000000000000000000000000000000000000000000000000000003593 214.0
TLS2_k127_7174592_4 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000001964 206.0
TLS2_k127_7174592_5 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000001992 198.0
TLS2_k127_7174592_6 haloacid dehalogenase K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000001476 179.0
TLS2_k127_7174592_7 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000001693 165.0
TLS2_k127_7174592_8 Rieske 2Fe-2S - - - 0.000000000000000000000000000000000000001486 165.0
TLS2_k127_7174592_9 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000007625 159.0
TLS2_k127_7375715_0 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009689 525.0
TLS2_k127_7375715_1 all-trans-retinol 13,14-reductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008255 512.0
TLS2_k127_7375715_10 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 291.0
TLS2_k127_7375715_11 Belongs to the enoyl-CoA hydratase isomerase family K01692 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000004266 259.0
TLS2_k127_7375715_12 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001093 258.0
TLS2_k127_7375715_13 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000002405 235.0
TLS2_k127_7375715_14 ABC-type Na efflux pump, permease K01992 - - 0.0000000000000000000000000000000000000000000000000000000000001033 228.0
TLS2_k127_7375715_15 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000001314 220.0
TLS2_k127_7375715_16 PFAM Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000008484 202.0
TLS2_k127_7375715_17 Flavodoxin K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000000000001813 184.0
TLS2_k127_7375715_18 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000008766 181.0
TLS2_k127_7375715_19 Amidinotransferase K01482 - 3.5.3.18 0.000000000000000000000000000000000000000000005481 184.0
TLS2_k127_7375715_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 482.0
TLS2_k127_7375715_20 - - - - 0.000000000000000000000000000000000000001188 157.0
TLS2_k127_7375715_21 Cupin domain - - - 0.0000000000000000000000000006322 119.0
TLS2_k127_7375715_22 PspC domain - - - 0.00000000000000000000000001232 123.0
TLS2_k127_7375715_23 PAS fold K18350 - 2.7.13.3 0.00000000000000000000001415 115.0
TLS2_k127_7375715_24 - - - - 0.00000000000007166 81.0
TLS2_k127_7375715_25 - - - - 0.000000001166 67.0
TLS2_k127_7375715_26 - - - - 0.0004815 49.0
TLS2_k127_7375715_3 Histidinol dehydrogenase K00013,K15509 - 1.1.1.23,1.1.1.308 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009691 441.0
TLS2_k127_7375715_4 Peptidase family S58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 421.0
TLS2_k127_7375715_5 sarcosine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007569 353.0
TLS2_k127_7375715_6 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006464 319.0
TLS2_k127_7375715_7 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 295.0
TLS2_k127_7375715_8 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006577 294.0
TLS2_k127_7375715_9 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 295.0
TLS2_k127_846800_0 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000004499 185.0
TLS2_k127_846800_1 Histidine kinase - - - 0.00000000000003647 86.0
TLS2_k127_8628_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812,K08351 - 1.7.2.3 2.535e-282 887.0
TLS2_k127_8628_1 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000000000001535 94.0
TLS2_k127_8628_2 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000001382 75.0
TLS2_k127_935871_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.0 1092.0
TLS2_k127_935871_1 Cation transporter/ATPase, N-terminus K01537,K01539 - 3.6.3.8,3.6.3.9 1.376e-257 827.0
TLS2_k127_935871_10 FAD linked oxidases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 372.0
TLS2_k127_935871_11 beta-1,4-mannooligosaccharide phosphorylase K20885 - 2.4.1.339,2.4.1.340 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004872 374.0
TLS2_k127_935871_12 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 323.0
TLS2_k127_935871_13 Purine nucleoside phosphorylase K03784 GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009164,GO:0009987,GO:0015949,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0019686,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 321.0
TLS2_k127_935871_14 Oxidoreductase molybdopterin binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 319.0
TLS2_k127_935871_15 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 312.0
TLS2_k127_935871_16 formyltetrahydrofolate deformylase activity K00974,K01433 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006753,GO:0006760,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008864,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009256,GO:0009257,GO:0009259,GO:0009260,GO:0009396,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0034641,GO:0034654,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.72,3.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005952 304.0
TLS2_k127_935871_17 Oxidoreductase FAD-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006565 309.0
TLS2_k127_935871_18 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 286.0
TLS2_k127_935871_19 DNA synthesis involved in DNA repair - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008505 284.0
TLS2_k127_935871_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 6.716e-257 804.0
TLS2_k127_935871_20 AzlC protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001197 265.0
TLS2_k127_935871_21 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003127 273.0
TLS2_k127_935871_22 Alcohol dehydrogenase GroES-like domain K00004 - 1.1.1.303,1.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000001299 266.0
TLS2_k127_935871_23 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000009727 251.0
TLS2_k127_935871_24 Transport permease protein K09694 - - 0.00000000000000000000000000000000000000000000000000000000000000002887 237.0
TLS2_k127_935871_25 TrkA-N domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000001107 229.0
TLS2_k127_935871_26 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000008514 220.0
TLS2_k127_935871_27 - - - - 0.0000000000000000000000000000000000000000000000000000000006181 205.0
TLS2_k127_935871_28 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000883 205.0
TLS2_k127_935871_29 TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000000000003244 219.0
TLS2_k127_935871_3 PFAM FMN-dependent alpha-hydroxy acid dehydrogenase K00101,K00104 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 1.1.2.3,1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 527.0
TLS2_k127_935871_30 Uncharacterised protein family UPF0066 - - - 0.000000000000000000000000000000000000000000000000000000003385 201.0
TLS2_k127_935871_31 acetylesterase activity - - - 0.0000000000000000000000000000000000000000000000000000000143 209.0
TLS2_k127_935871_32 ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000001583 208.0
TLS2_k127_935871_33 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00042 - 1.1.1.60 0.0000000000000000000000000000000000000000000000000007858 196.0
TLS2_k127_935871_34 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000622 180.0
TLS2_k127_935871_35 - - - - 0.000000000000000000000000000000000000000000000006023 186.0
TLS2_k127_935871_36 phosphatase - - - 0.0000000000000000000000000000000000000000000001687 177.0
TLS2_k127_935871_37 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000001092 164.0
TLS2_k127_935871_38 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000007314 161.0
TLS2_k127_935871_39 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000007969 165.0
TLS2_k127_935871_4 Transketolase, C-terminal domain K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 485.0
TLS2_k127_935871_40 - - - - 0.0000000000000000000000000000000000001581 146.0
TLS2_k127_935871_41 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000001172 141.0
TLS2_k127_935871_42 transcriptional - - - 0.0000000000000000000000000000000001308 136.0
TLS2_k127_935871_43 COG1525 Micrococcal nuclease (thermonuclease) homologs K01174 - 3.1.31.1 0.0000000000000000000000000000000001575 148.0
TLS2_k127_935871_44 SNARE associated Golgi protein - - - 0.000000000000000000000000000000007735 140.0
TLS2_k127_935871_45 Fasciclin - GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043207,GO:0044403,GO:0044419,GO:0044421,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071944,GO:0075136 - 0.0000000000000000000000000000009261 129.0
TLS2_k127_935871_46 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000001148 131.0
TLS2_k127_935871_47 Nitroreductase family - - - 0.0000000000000000000000007571 109.0
TLS2_k127_935871_48 Electron transfer DM13 - - - 0.000000000000000000000006824 109.0
TLS2_k127_935871_49 - - - - 0.000000000000000000001089 100.0
TLS2_k127_935871_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 475.0
TLS2_k127_935871_50 OsmC-like protein - - - 0.00000000000000000002207 99.0
TLS2_k127_935871_51 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000000000000000002947 104.0
TLS2_k127_935871_52 - - - - 0.0000000000000001124 92.0
TLS2_k127_935871_53 protein with SCP PR1 domains - - - 0.0000000000000001449 91.0
TLS2_k127_935871_54 S-layer homology domain - - - 0.0000000000005059 80.0
TLS2_k127_935871_56 Phosphopantetheine attachment site - - - 0.000000000002198 74.0
TLS2_k127_935871_57 - - - - 0.00000000003592 73.0
TLS2_k127_935871_58 branched-chain amino acid - - - 0.000000002111 65.0
TLS2_k127_935871_6 ABC transporter K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006938 426.0
TLS2_k127_935871_7 PFAM chorismate K01665,K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 435.0
TLS2_k127_935871_8 permease K06901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007818 423.0
TLS2_k127_935871_9 e3 binding domain K00627,K00658 - 2.3.1.12,2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007135 417.0
TLS2_k127_93886_0 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 614.0
TLS2_k127_93886_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003283 523.0
TLS2_k127_93886_10 PFAM FAD linked oxidase domain protein K00104,K11472 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.3.15 0.00000000000000000000000000000000000000006436 166.0
TLS2_k127_93886_11 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000001405 132.0
TLS2_k127_93886_12 - - - - 0.00000000000000000000000002608 119.0
TLS2_k127_93886_13 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000001473 108.0
TLS2_k127_93886_14 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000007621 83.0
TLS2_k127_93886_15 Belongs to the sulfur carrier protein TusA family K04085 - - 0.00000000000002366 77.0
TLS2_k127_93886_16 Scaffold protein Nfu NifU - - - 0.000000001279 62.0
TLS2_k127_93886_17 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000009088 59.0
TLS2_k127_93886_2 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 499.0
TLS2_k127_93886_3 Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039 437.0
TLS2_k127_93886_4 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 369.0
TLS2_k127_93886_5 PFAM Transketolase central region K00167 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 370.0
TLS2_k127_93886_6 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004679 342.0
TLS2_k127_93886_7 Fe-S oxidoreductase K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000008739 250.0
TLS2_k127_93886_8 DNA alkylation repair enzyme - - - 0.0000000000000000000000000000000000000000000000000000002335 203.0
TLS2_k127_93886_9 Cyclase dehydrase - - - 0.000000000000000000000000000000000000000001384 160.0
TLS2_k127_964287_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.754e-214 678.0
TLS2_k127_964287_1 Biotin carboxylase, N-terminal domain K11263 - 6.3.4.14,6.4.1.2,6.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 555.0
TLS2_k127_964287_10 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000002515 190.0
TLS2_k127_964287_11 SpoIID LytB domain protein - - - 0.0000000000000000000000000000000000000000000001718 190.0
TLS2_k127_964287_12 PFAM Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000004054 173.0
TLS2_k127_964287_13 - - - - 0.00000000000000000000000000000000000000000001597 183.0
TLS2_k127_964287_14 - - - - 0.0000000000000000000000000000004042 137.0
TLS2_k127_964287_15 polysaccharide biosynthetic process - GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009987,GO:0044764,GO:0046812,GO:0051704 - 0.000000000000000001753 98.0
TLS2_k127_964287_16 S-layer homology domain - - - 0.00000000000002907 87.0
TLS2_k127_964287_17 - - - - 0.00000002573 63.0
TLS2_k127_964287_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 434.0
TLS2_k127_964287_3 UDP binding domain K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007963 396.0
TLS2_k127_964287_4 Bacterial sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006324 376.0
TLS2_k127_964287_5 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 333.0
TLS2_k127_964287_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003669 354.0
TLS2_k127_964287_7 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006545 302.0
TLS2_k127_964287_8 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001508 282.0
TLS2_k127_964287_9 Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000005173 252.0
TLS2_k127_981619_0 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 7.209e-240 769.0
TLS2_k127_981619_1 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000005688 203.0
TLS2_k127_981619_2 Protein of unknown function (DUF501) K09009 - - 0.000000000000000000000000000009237 124.0
TLS2_k127_981619_3 Septum formation initiator - - - 0.00000000401 62.0