Overview

ID MAG03999
Name TLS2_bin.32
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Desulfobacterota_B
Class Binatia
Order UBA9968
Family UBA9968
Genus DP-20
Species
Assembly information
Completeness (%) 83.01
Contamination (%) 6.27
GC content (%) 58.0
N50 (bp) 27,460
Genome size (bp) 4,323,393

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3871

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1004280_0 Domain of unknown function (DUF4105) - - - 1.645e-212 679.0
TLS2_k127_1004280_1 Protein of unknown function (DUF3015) - - - 0.00000000000000000000000000000000000000000003637 166.0
TLS2_k127_1004280_2 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000002328 128.0
TLS2_k127_1004280_3 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.000000000000000002029 97.0
TLS2_k127_1004280_4 Molybdopterin-binding domain of aldehyde dehydrogenase - - - 0.00000000000000003218 84.0
TLS2_k127_1004280_5 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000001345 85.0
TLS2_k127_1004280_6 Tripartite tricarboxylate transporter TctA family - - - 0.000000000612 63.0
TLS2_k127_1018833_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00122,K00335 - 1.17.1.9,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005314 472.0
TLS2_k127_1018833_1 Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (PorD-like) K00171 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007982 347.0
TLS2_k127_1018833_2 Regulatory protein GntR HTH K05799 - - 0.0000000000000000000000000000000000000000127 163.0
TLS2_k127_1018833_3 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000272 155.0
TLS2_k127_1019292_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 600.0
TLS2_k127_1019292_1 PFAM fumarate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 562.0
TLS2_k127_1019292_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000951 558.0
TLS2_k127_1019292_3 TIGRFAM acetylornithine and succinylornithine K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006615 506.0
TLS2_k127_1019292_4 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 495.0
TLS2_k127_1019292_5 Amino acid kinase family K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 391.0
TLS2_k127_1019292_6 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 359.0
TLS2_k127_1019292_7 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000002944 73.0
TLS2_k127_1019292_8 Fibronectin type 3 domain - - - 0.0000006137 57.0
TLS2_k127_1063709_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005436 391.0
TLS2_k127_1063709_1 ATPase associated with various cellular activities AAA_5 K04748 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003912 357.0
TLS2_k127_1063709_2 Cupin 2, conserved barrel domain protein K00450,K11948 - 1.13.11.38,1.13.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003824 282.0
TLS2_k127_1063709_3 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001552 243.0
TLS2_k127_1063709_4 addiction module antidote protein - - - 0.000000000000000000000000000000000000000000002128 169.0
TLS2_k127_1063709_5 addiction module killer protein - - - 0.00000000000000000000000000000000000000000004515 162.0
TLS2_k127_1063709_6 Amidohydrolase - - - 0.0009536 48.0
TLS2_k127_1070435_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004483 534.0
TLS2_k127_1070435_1 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000871 462.0
TLS2_k127_1070435_10 to Salmonella typhimurium, and Salmonella typhi transposase for insertion sequence IS200 TnpA SW T200_SALTY (Q57334) (152 aa) fasta scores E() 0, 94.1 id in 152 aa. Identical to the Yersinia pseudotuberculosis IS1541-like element transposase Tnp TR Q9X9F5 (EMBL AJ238014) (152 aa) fasta scores E() 0, 100.0 id in 152 aa K07491 - - 0.000000000003366 69.0
TLS2_k127_1070435_2 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003952 447.0
TLS2_k127_1070435_3 Belongs to the peptidase S1C family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 347.0
TLS2_k127_1070435_4 PFAM ABC transporter related K01990,K19340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 309.0
TLS2_k127_1070435_5 cell adhesion involved in biofilm formation K07407 - 3.2.1.22 0.00000000000000000000000000000000000000000000000000000000000003859 231.0
TLS2_k127_1070435_6 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000002553 185.0
TLS2_k127_1070435_7 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000003972 182.0
TLS2_k127_1070435_8 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000005467 165.0
TLS2_k127_1070435_9 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.0000000000000000000000000000000000000001424 155.0
TLS2_k127_1079953_0 Protein of unknown function (DUF1298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001735 237.0
TLS2_k127_1079953_1 Histone methylation protein DOT1 - - - 0.000000000000000000000000000000000000000000000000000000005416 207.0
TLS2_k127_1079953_2 PFAM electron transport protein SCO1 SenC K07152 - - 0.000000000000000000000000000000002132 137.0
TLS2_k127_1082774_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 354.0
TLS2_k127_1082774_1 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.000000000000000000000000000000000000000000003023 172.0
TLS2_k127_1082774_2 cyclopropane-fatty-acyl-phospholipid synthase K05928 - 2.1.1.95 0.000000000000000000000000000000000000000002475 160.0
TLS2_k127_1082774_3 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000042 137.0
TLS2_k127_1082774_4 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000194 82.0
TLS2_k127_1087682_0 Involved in chromosome partitioning - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006255 275.0
TLS2_k127_1087682_1 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000009007 188.0
TLS2_k127_1087682_2 TRAP transporter solute receptor TAXI family protein - - - 0.0000000000000000000000000000000000000000000000000001243 202.0
TLS2_k127_1087682_3 - - - - 0.000000000000000000000000000000001388 135.0
TLS2_k127_1089359_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 1.133e-262 834.0
TLS2_k127_1089359_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 1.459e-207 676.0
TLS2_k127_1089359_10 Phage integrase, N-terminal SAM-like domain K03733,K04763 GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009965 303.0
TLS2_k127_1089359_11 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005328 282.0
TLS2_k127_1089359_12 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000768 280.0
TLS2_k127_1089359_13 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003572 274.0
TLS2_k127_1089359_14 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000001028 252.0
TLS2_k127_1089359_15 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008193 246.0
TLS2_k127_1089359_16 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000004759 222.0
TLS2_k127_1089359_17 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000000000000000000000000000000000000002841 226.0
TLS2_k127_1089359_18 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000004638 207.0
TLS2_k127_1089359_19 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000006011 199.0
TLS2_k127_1089359_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 5.47e-203 643.0
TLS2_k127_1089359_20 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000821 184.0
TLS2_k127_1089359_21 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.0000000000000000000000000000000000000001754 155.0
TLS2_k127_1089359_22 Belongs to the UPF0102 family K07460 - - 0.000000000000000000000000000002433 124.0
TLS2_k127_1089359_23 - - - - 0.000000000000000000000000000002864 127.0
TLS2_k127_1089359_24 cellulose binding - - - 0.000000000000000000000001939 115.0
TLS2_k127_1089359_25 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000001743 102.0
TLS2_k127_1089359_26 PFAM Prenyltransferase squalene oxidase - - - 0.00000000000000000006534 100.0
TLS2_k127_1089359_27 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding - - - 0.00000000000000000329 93.0
TLS2_k127_1089359_28 aspartic-type endopeptidase activity K06985 - - 0.00000000001806 75.0
TLS2_k127_1089359_29 Lysin motif - - - 0.00000000005617 75.0
TLS2_k127_1089359_3 DEAD DEAH box helicase K03654 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 607.0
TLS2_k127_1089359_30 Histidine kinase - - - 0.000000000149 71.0
TLS2_k127_1089359_31 Sporulation related domain - - - 0.000004793 60.0
TLS2_k127_1089359_32 phosphorelay signal transduction system - - - 0.000008642 57.0
TLS2_k127_1089359_33 PFAM copper amine oxidase domain protein - - - 0.0007228 51.0
TLS2_k127_1089359_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K01876,K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.12,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 583.0
TLS2_k127_1089359_5 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 562.0
TLS2_k127_1089359_6 ThiF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004539 492.0
TLS2_k127_1089359_7 TIGRFAM Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 437.0
TLS2_k127_1089359_8 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 407.0
TLS2_k127_1089359_9 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 317.0
TLS2_k127_1140300_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 3.314e-226 720.0
TLS2_k127_1140300_1 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 7.367e-196 616.0
TLS2_k127_1140300_10 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000003118 179.0
TLS2_k127_1140300_11 Galactose oxidase, central domain - - - 0.00000000000000000000000000000000000000004178 177.0
TLS2_k127_1140300_12 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000009435 135.0
TLS2_k127_1140300_13 Belongs to the ompA family K03640 - - 0.0000000000000004263 88.0
TLS2_k127_1140300_14 PFAM carbon monoxide dehydrogenase subunit G K09386 - - 0.0000000117 63.0
TLS2_k127_1140300_15 SPTR CHU large protein - - - 0.00000006753 67.0
TLS2_k127_1140300_2 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 423.0
TLS2_k127_1140300_3 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007478 337.0
TLS2_k127_1140300_4 PFAM Bacterial protein of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005205 265.0
TLS2_k127_1140300_5 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000105 225.0
TLS2_k127_1140300_6 pathogenesis K20276 - - 0.0000000000000000000000000000000000000000000000000000000001823 234.0
TLS2_k127_1140300_7 [2Fe-2S] binding domain - - - 0.0000000000000000000000000000000000000000000000000000000005329 206.0
TLS2_k127_1140300_8 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000008801 199.0
TLS2_k127_1140300_9 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.0000000000000000000000000000000000000000000000000005003 193.0
TLS2_k127_1158183_0 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 385.0
TLS2_k127_1158183_1 - - - - 0.00000000000000000000005368 106.0
TLS2_k127_1158183_2 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000002832 49.0
TLS2_k127_1171812_0 Cytochrome c - - - 0.0 1112.0
TLS2_k127_1171812_1 Fe-S oxidoreductase - - - 5.054e-316 979.0
TLS2_k127_1171812_10 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 402.0
TLS2_k127_1171812_11 regulatory protein IclR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004529 275.0
TLS2_k127_1171812_12 with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine K01664 GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000003029 269.0
TLS2_k127_1171812_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002253 224.0
TLS2_k127_1171812_14 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.00000000000000000000000000000000000000000000000000005393 204.0
TLS2_k127_1171812_15 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000007066 126.0
TLS2_k127_1171812_16 Threonyl-tRNA synthetase - - - 0.000000000000000000000001469 108.0
TLS2_k127_1171812_17 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000001482 102.0
TLS2_k127_1171812_18 Amidohydrolase K03392 - 4.1.1.45 0.000000000000004897 79.0
TLS2_k127_1171812_19 Cell Wall K01448 - 3.5.1.28 0.000002535 57.0
TLS2_k127_1171812_2 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 4.327e-251 788.0
TLS2_k127_1171812_3 cytochrome C peroxidase - - - 2.458e-238 744.0
TLS2_k127_1171812_4 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 1.079e-227 730.0
TLS2_k127_1171812_5 Putative modulator of DNA gyrase K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 6.851e-211 664.0
TLS2_k127_1171812_6 cytochrome C peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 546.0
TLS2_k127_1171812_7 Putative modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003629 534.0
TLS2_k127_1171812_8 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 518.0
TLS2_k127_1171812_9 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 424.0
TLS2_k127_120048_0 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004284 595.0
TLS2_k127_120048_1 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 591.0
TLS2_k127_120048_10 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000618 297.0
TLS2_k127_120048_11 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000002374 235.0
TLS2_k127_120048_12 2Fe-2S -binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000008473 204.0
TLS2_k127_120048_13 Class ii aldolase K01628,K18256 - 4.1.1.69,4.1.2.17 0.000000000000000000000000000000000000000000000000000001653 200.0
TLS2_k127_120048_14 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000002371 195.0
TLS2_k127_120048_15 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000001124 199.0
TLS2_k127_120048_16 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000002587 198.0
TLS2_k127_120048_17 - - - - 0.0000000000000000000000000000000000000000000000001872 181.0
TLS2_k127_120048_18 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000003747 190.0
TLS2_k127_120048_19 Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000005587 171.0
TLS2_k127_120048_2 Belongs to the UbiD family K03182 - 4.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 577.0
TLS2_k127_120048_20 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0000000000000000000000000000000001616 134.0
TLS2_k127_120048_21 FCD - - - 0.0000000000000000000000000000008422 131.0
TLS2_k127_120048_22 UTRA K03486,K03710 - - 0.0000000000000000000000004249 114.0
TLS2_k127_120048_23 Glyoxalase-like domain K08234 - - 0.0000000000000000000000005583 111.0
TLS2_k127_120048_24 NMT1-like family K02051 - - 0.0000000000000002072 87.0
TLS2_k127_120048_25 PA26 p53-induced protein (sestrin) - - - 0.0000000000000006085 82.0
TLS2_k127_120048_26 Putative addiction module component - - - 0.000000000000002858 78.0
TLS2_k127_120048_27 Cupin - - - 0.000000000000006875 79.0
TLS2_k127_120048_28 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000002075 70.0
TLS2_k127_120048_29 Carboxymuconolactone decarboxylase family - - - 0.00003883 50.0
TLS2_k127_120048_3 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009067 564.0
TLS2_k127_120048_4 Bacterial regulatory protein, Fis family K02481,K07713,K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 452.0
TLS2_k127_120048_5 Amidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 423.0
TLS2_k127_120048_6 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 389.0
TLS2_k127_120048_7 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 370.0
TLS2_k127_120048_8 COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 340.0
TLS2_k127_120048_9 COG3842 ABC-type spermidine putrescine transport systems, ATPase components K02010,K02017,K15497 - 3.6.3.29,3.6.3.30,3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004159 327.0
TLS2_k127_1200519_0 Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 533.0
TLS2_k127_1200519_1 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 378.0
TLS2_k127_1200519_2 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006943 278.0
TLS2_k127_1200519_3 NMT1-like family - - - 0.00000000000000000000000000000000000000000004244 173.0
TLS2_k127_1200519_4 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000004843 115.0
TLS2_k127_1200519_5 Tripartite tricarboxylate transporter family receptor - - - 0.0000000001601 67.0
TLS2_k127_1200519_6 Belongs to the enoyl-CoA hydratase isomerase family K08299,K15866 - 4.2.1.149,5.3.3.18 0.00000001348 57.0
TLS2_k127_1200519_7 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.00002242 48.0
TLS2_k127_1200519_8 Enoyl-CoA hydratase/isomerase - - - 0.00004694 49.0
TLS2_k127_120316_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 3.222e-221 716.0
TLS2_k127_120316_1 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 579.0
TLS2_k127_120316_2 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001388 250.0
TLS2_k127_120316_3 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000001612 246.0
TLS2_k127_120316_4 TIM-barrel fold metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001081 249.0
TLS2_k127_120316_5 NMT1-like family K02051 - - 0.000000000000000000138 98.0
TLS2_k127_120316_6 Methyltransferase - - - 0.0000000000008603 70.0
TLS2_k127_120316_7 - - - - 0.0000000588 56.0
TLS2_k127_120316_8 uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center - GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0043446,GO:0043448,GO:0044237,GO:0044248,GO:0071704,GO:1901575 - 0.000001444 58.0
TLS2_k127_1226998_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 2.548e-196 635.0
TLS2_k127_1226998_1 Belongs to the thiolase family K00626,K02615 - 2.3.1.174,2.3.1.223,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 527.0
TLS2_k127_1226998_10 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000005109 213.0
TLS2_k127_1226998_11 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000002343 200.0
TLS2_k127_1226998_12 Bacterial regulatory proteins, tetR family K09017 - - 0.000000000000000000000000000000000000001384 156.0
TLS2_k127_1226998_13 PFAM Patatin K07001 - - 0.00000000000000000000000007538 107.0
TLS2_k127_1226998_14 VIT family - - - 0.0000000000000000001301 98.0
TLS2_k127_1226998_15 Universal stress protein - - - 0.0000007763 58.0
TLS2_k127_1226998_16 Domain of unknown function (DUF4911) - - - 0.00001194 55.0
TLS2_k127_1226998_17 Protein involved in outer membrane biogenesis K07289 - - 0.00001454 59.0
TLS2_k127_1226998_18 Amidohydrolase K07045 - - 0.00002311 52.0
TLS2_k127_1226998_19 Belongs to the peptidase S26 family - - - 0.00004451 51.0
TLS2_k127_1226998_2 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 493.0
TLS2_k127_1226998_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007938 490.0
TLS2_k127_1226998_4 Belongs to the HpcH HpaI aldolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 379.0
TLS2_k127_1226998_5 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005823 338.0
TLS2_k127_1226998_6 PFAM amidohydrolase 2 K10220,K14333 - 4.1.1.46,4.2.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 335.0
TLS2_k127_1226998_7 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 317.0
TLS2_k127_1226998_8 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 293.0
TLS2_k127_1226998_9 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008877 291.0
TLS2_k127_1227984_0 Type III restriction K01153 - 3.1.21.3 9.222e-291 899.0
TLS2_k127_1227984_1 PFAM N-6 DNA methylase K03427 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 390.0
TLS2_k127_1236283_0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 2.733e-250 781.0
TLS2_k127_1236283_1 Belongs to the UbiD family K01612 - 4.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 556.0
TLS2_k127_1236283_10 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00001299 56.0
TLS2_k127_1236283_11 Cupin domain - - - 0.0003655 51.0
TLS2_k127_1236283_2 Pfam Cupin K00450,K11948 - 1.13.11.38,1.13.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002848 283.0
TLS2_k127_1236283_3 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000001667 211.0
TLS2_k127_1236283_4 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000001385 203.0
TLS2_k127_1236283_5 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000001181 197.0
TLS2_k127_1236283_6 proteolysis K21140,K21147 - 2.7.7.80,2.8.1.11,3.13.1.6 0.000000000000000000000000000000000001041 144.0
TLS2_k127_1236283_7 Transglycosylase SLT domain K08309 - - 0.000000000000000000002579 102.0
TLS2_k127_1236283_8 - - - - 0.000000000000000001282 91.0
TLS2_k127_1236283_9 Putative regulatory protein - - - 0.000000000000000001344 89.0
TLS2_k127_1242608_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004422 573.0
TLS2_k127_1242608_1 Arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006449 570.0
TLS2_k127_1242608_10 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 380.0
TLS2_k127_1242608_11 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 342.0
TLS2_k127_1242608_12 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007927 346.0
TLS2_k127_1242608_13 Cell cycle protein K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 337.0
TLS2_k127_1242608_14 ABC transporter, ATP-binding protein K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000072 299.0
TLS2_k127_1242608_15 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 304.0
TLS2_k127_1242608_16 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 290.0
TLS2_k127_1242608_17 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001156 285.0
TLS2_k127_1242608_18 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003902 294.0
TLS2_k127_1242608_19 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003769 275.0
TLS2_k127_1242608_2 PASTA domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006537 552.0
TLS2_k127_1242608_20 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000001757 255.0
TLS2_k127_1242608_21 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000001476 246.0
TLS2_k127_1242608_22 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000000000001267 248.0
TLS2_k127_1242608_23 PFAM Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000645 223.0
TLS2_k127_1242608_24 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000001147 216.0
TLS2_k127_1242608_25 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000008418 169.0
TLS2_k127_1242608_26 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00042 - 1.1.1.60 0.00000000000000000000000000000000000006681 154.0
TLS2_k127_1242608_27 PFAM ribonuclease H K03469,K06864 - 3.1.26.4 0.0000000000000000000000000000000000001229 147.0
TLS2_k127_1242608_28 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.0000000000000000000000000000000001313 137.0
TLS2_k127_1242608_29 Citrate transporter - - - 0.00000000000000000000000000000000133 130.0
TLS2_k127_1242608_3 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007034 540.0
TLS2_k127_1242608_30 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.00000000000000000000000000000001929 138.0
TLS2_k127_1242608_31 Essential cell division protein K03589 - - 0.00000000000000000000000001583 119.0
TLS2_k127_1242608_32 C4-type zinc ribbon domain K07164 - - 0.0000000000000000000000000544 117.0
TLS2_k127_1242608_33 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000009219 115.0
TLS2_k127_1242608_34 ABC-type branched-chain amino acid transport K01999 - - 0.00000000000000008766 85.0
TLS2_k127_1242608_35 SPTR Integrase, catalytic region - - - 0.0000000000003194 74.0
TLS2_k127_1242608_36 STAS domain K04749 - - 0.0000000000004942 73.0
TLS2_k127_1242608_37 Glycosyl transferase family group 2 - - - 0.000000000006412 74.0
TLS2_k127_1242608_38 Universal stress protein family - - - 0.000000000006715 72.0
TLS2_k127_1242608_39 G COG1172 Ribose xylose arabinose galactoside ABC-type transport systems, permease components K01998 - - 0.000000001222 59.0
TLS2_k127_1242608_4 UDP-N-acetylmuramate-L-alanine ligase activity K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 540.0
TLS2_k127_1242608_40 - - - - 0.00000003718 59.0
TLS2_k127_1242608_42 Anti-sigma factor K07167 - - 0.00001578 52.0
TLS2_k127_1242608_44 Tripartite tricarboxylate transporter family receptor - - - 0.0004233 52.0
TLS2_k127_1242608_45 Sporulation related domain K03591 - - 0.0007461 50.0
TLS2_k127_1242608_5 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 471.0
TLS2_k127_1242608_6 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008821 461.0
TLS2_k127_1242608_7 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 453.0
TLS2_k127_1242608_8 Belongs to the D-alanine--D-alanine ligase family K01921 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003746 445.0
TLS2_k127_1242608_9 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008934 398.0
TLS2_k127_1257712_0 PFAM ABC transporter related K06020 - 3.6.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 520.0
TLS2_k127_1257712_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 324.0
TLS2_k127_1257712_2 PFAM amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 303.0
TLS2_k127_1257712_3 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.000000000001472 78.0
TLS2_k127_12673_0 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 5.058e-231 738.0
TLS2_k127_12673_1 Protein of unknown function (DUF3500) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 380.0
TLS2_k127_12673_10 ABC transporter substrate-binding protein K15551 - - 0.00002448 56.0
TLS2_k127_12673_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004884 253.0
TLS2_k127_12673_3 TPR repeat - - - 0.00000000000000000000000000000000000000000000000001211 196.0
TLS2_k127_12673_4 metal-dependent hydrolase of the TIM-barrel fold - - - 0.0000000000000000000000000000000000000000001107 173.0
TLS2_k127_12673_5 RNA recognition motif - - - 0.0000000000000000000000000000000005465 132.0
TLS2_k127_12673_7 - - - - 0.0000000000003766 71.0
TLS2_k127_12673_9 - - - - 0.000003214 49.0
TLS2_k127_1293226_0 Putative amidoligase enzyme (DUF2126) - - - 0.0 1792.0
TLS2_k127_1293226_1 Circularly permuted ATP-grasp type 2 - - - 2.211e-266 844.0
TLS2_k127_1293226_10 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source - - - 0.0000000000000000000000000000000000000000001797 169.0
TLS2_k127_1293226_11 PFAM S23 ribosomal protein - - - 0.000000000000000000000000000002254 124.0
TLS2_k127_1293226_12 PFAM transglutaminase domain protein - - - 0.00000000000000000000000004144 113.0
TLS2_k127_1293226_13 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.000000000000848 79.0
TLS2_k127_1293226_2 Circularly permuted ATP-grasp type 2 - - - 1.073e-228 717.0
TLS2_k127_1293226_3 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 535.0
TLS2_k127_1293226_4 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K00087 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 425.0
TLS2_k127_1293226_5 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 389.0
TLS2_k127_1293226_6 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 383.0
TLS2_k127_1293226_7 Bacterial transglutaminase-like N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 349.0
TLS2_k127_1293226_8 Trypsin-like peptidase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 336.0
TLS2_k127_1293226_9 Bacterial transglutaminase-like N-terminal region - - - 0.000000000000000000000000000000000000000000003694 173.0
TLS2_k127_13229_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 6.847e-290 904.0
TLS2_k127_13229_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005419 589.0
TLS2_k127_13229_10 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 299.0
TLS2_k127_13229_11 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004481 293.0
TLS2_k127_13229_12 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007472 295.0
TLS2_k127_13229_13 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002386 255.0
TLS2_k127_13229_14 PFAM cation efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001279 239.0
TLS2_k127_13229_15 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000007283 237.0
TLS2_k127_13229_16 Fatty acid desaturase - - - 0.00000000000000000000000000000000000000000000000000000000000000002839 234.0
TLS2_k127_13229_17 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000463 223.0
TLS2_k127_13229_18 Histidine-specific methyltransferase, SAM-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000002977 231.0
TLS2_k127_13229_19 beta-N-acetylglucosaminidase K01197,K15719 GO:0003674,GO:0003824,GO:0004553,GO:0004563,GO:0005488,GO:0005515,GO:0005975,GO:0006464,GO:0006517,GO:0006807,GO:0008150,GO:0008152,GO:0009100,GO:0009987,GO:0015929,GO:0016231,GO:0016787,GO:0016798,GO:0019538,GO:0030246,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901135,GO:1901564 2.3.1.48,3.2.1.169,3.2.1.35 0.0000000000000000000000000000000000000000000000000000000000004214 225.0
TLS2_k127_13229_2 PFAM Bile acid sodium symporter K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 526.0
TLS2_k127_13229_20 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000004626 190.0
TLS2_k127_13229_21 threonine efflux protein - - - 0.000000000000000000000000000000000000000000000000000366 191.0
TLS2_k127_13229_22 PFAM Formylglycine-generating sulfatase enzyme K18912,K20333 - 1.14.99.50 0.00000000000000000000000000000000000000000000000003174 190.0
TLS2_k127_13229_23 Universal stress protein - - - 0.00000000000000000000000000000000000000000000000003189 190.0
TLS2_k127_13229_24 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000005908 193.0
TLS2_k127_13229_25 Regulatory protein ArsR K03892 - - 0.0000000000000000000000000000000000000000000001113 171.0
TLS2_k127_13229_26 Membrane - - - 0.0000000000000000000000000000000000000000000216 166.0
TLS2_k127_13229_27 Protein involved in meta-pathway of phenol degradation - - - 0.000000000000000000000000000000000000001246 158.0
TLS2_k127_13229_28 Type III restriction enzyme, res subunit - - - 0.000000000000000000000000000000000000005061 149.0
TLS2_k127_13229_29 Protein of unknown function (DUF1232) - - - 0.0000000000000000000000000000000001832 136.0
TLS2_k127_13229_3 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 522.0
TLS2_k127_13229_30 GDP-mannose 4,6 dehydratase K01784 - 5.1.3.2 0.0000000000000000000000132 112.0
TLS2_k127_13229_31 Serine aminopeptidase, S33 K01055,K16050 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016822,GO:0016823,GO:0030312,GO:0034820,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 3.1.1.24,3.7.1.17 0.0000000000000000001563 99.0
TLS2_k127_13229_32 - - - - 0.0000000000000002148 88.0
TLS2_k127_13229_33 photosynthesis K02656 - - 0.000000000000004954 84.0
TLS2_k127_13229_34 Peptidase propeptide and YPEB domain - - - 0.000000000379 63.0
TLS2_k127_13229_35 NMT1-like family K02051 - - 0.000000004046 68.0
TLS2_k127_13229_36 Peptidase propeptide and YPEB domain - - - 0.0000006073 56.0
TLS2_k127_13229_37 Sodium Bile acid symporter family K03325 - - 0.00008226 45.0
TLS2_k127_13229_38 Putative Flp pilus-assembly TadE/G-like - - - 0.0009311 51.0
TLS2_k127_13229_4 DinB superfamily K18912 - 1.14.99.50 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007745 494.0
TLS2_k127_13229_5 Peptidase dimerisation domain K13049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 475.0
TLS2_k127_13229_6 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008771 359.0
TLS2_k127_13229_7 SMART ATPase, AAA type, core K05847 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 327.0
TLS2_k127_13229_8 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007604 313.0
TLS2_k127_13229_9 PFAM Major Facilitator Superfamily K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 313.0
TLS2_k127_1323210_0 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005633 407.0
TLS2_k127_1323210_1 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008078 397.0
TLS2_k127_1323210_10 Methyltransferase domain K00570 - 2.1.1.17,2.1.1.71 0.0000000000000000000000000000000000000000000000002213 183.0
TLS2_k127_1323210_11 NMT1/THI5 like K02051 - - 0.000000000000000000000000000000000002969 151.0
TLS2_k127_1323210_12 Protein of unknown function (DUF1178) - - - 0.0000000000000000000000000005258 118.0
TLS2_k127_1323210_13 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000291 122.0
TLS2_k127_1323210_14 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system - - - 0.0000000000007114 70.0
TLS2_k127_1323210_15 DNA binding domain, excisionase family - - - 0.0002096 46.0
TLS2_k127_1323210_2 Peptidogalycan biosysnthesis/recognition K09919 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007327 365.0
TLS2_k127_1323210_3 Branched-chain-amino-acid aminotransferase-like protein 3 K18482 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008153,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0019438,GO:0019752,GO:0032787,GO:0042537,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046482,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.3.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006512 338.0
TLS2_k127_1323210_4 ornithine cyclodeaminase K01750 - 4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000779 336.0
TLS2_k127_1323210_5 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 339.0
TLS2_k127_1323210_6 PFAM ABC transporter K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001455 285.0
TLS2_k127_1323210_7 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001323 271.0
TLS2_k127_1323210_8 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000002172 264.0
TLS2_k127_1323210_9 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000001012 207.0
TLS2_k127_1373525_0 DDE_Tnp_1-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000515 445.0
TLS2_k127_1373525_1 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006472 339.0
TLS2_k127_1373525_10 - - - - 0.0000001649 63.0
TLS2_k127_1373525_11 lipolytic protein G-D-S-L family K18650 - 3.2.1.82 0.000001197 60.0
TLS2_k127_1373525_12 KR domain - - - 0.000003939 56.0
TLS2_k127_1373525_2 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002057 282.0
TLS2_k127_1373525_3 KR domain - - - 0.00000000000000000000000000000000000001537 149.0
TLS2_k127_1373525_4 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000007663 153.0
TLS2_k127_1373525_5 DDE_Tnp_1-associated - - - 0.00000000000000000000000000004509 124.0
TLS2_k127_1373525_6 Alpha beta hydrolase - - - 0.0000000000000000000000000003731 124.0
TLS2_k127_1373525_7 Amidohydrolase - - - 0.000000000000000002571 94.0
TLS2_k127_1373525_8 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.00000000000000005733 89.0
TLS2_k127_1373525_9 Transposase DDE domain - - - 0.00000000007622 71.0
TLS2_k127_138741_0 SMART Resolvase, RNase H domain protein fold K06959 - - 0.0 1125.0
TLS2_k127_138741_1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase - - - 9.987e-310 968.0
TLS2_k127_138741_10 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003568 244.0
TLS2_k127_138741_11 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000000000000000000000000001762 230.0
TLS2_k127_138741_12 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000001766 149.0
TLS2_k127_138741_13 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000003267 149.0
TLS2_k127_138741_14 decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000001608 138.0
TLS2_k127_138741_15 translation release factor activity - - - 0.0000000000000000000000000000000006826 136.0
TLS2_k127_138741_16 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000001233 124.0
TLS2_k127_138741_17 CBS domain K04767,K07168,K07182 - - 0.00000000000000000000000006816 113.0
TLS2_k127_138741_18 Amidohydrolase K07045 - - 0.0000000000000000000000005965 115.0
TLS2_k127_138741_19 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.000000000000000000000001604 108.0
TLS2_k127_138741_2 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 5.88e-264 840.0
TLS2_k127_138741_20 Universal stress protein - - - 0.000000000000000000000003949 109.0
TLS2_k127_138741_21 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.0000000000000000000005414 102.0
TLS2_k127_138741_22 PFAM Na Pi-cotransporter K03324 - - 0.00000000000000000001799 94.0
TLS2_k127_138741_23 ribosomal large subunit export from nucleus - - - 0.000000001653 64.0
TLS2_k127_138741_24 Evidence 4 Homologs of previously reported genes of K09981 - - 0.000000776 55.0
TLS2_k127_138741_3 Threonine dehydratase K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 426.0
TLS2_k127_138741_4 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 381.0
TLS2_k127_138741_5 AAA domain K07028 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003896 341.0
TLS2_k127_138741_6 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008227 319.0
TLS2_k127_138741_7 FAD dependent oxidoreductase K00244 - 1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 300.0
TLS2_k127_138741_8 Mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001577 287.0
TLS2_k127_138741_9 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001484 284.0
TLS2_k127_144941_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 2.605e-254 789.0
TLS2_k127_144941_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 3.264e-240 750.0
TLS2_k127_144941_10 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000001067 66.0
TLS2_k127_144941_11 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000005438 57.0
TLS2_k127_144941_3 ethanolamine utilization protein K04019 GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009,GO:0071704,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 370.0
TLS2_k127_144941_4 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 320.0
TLS2_k127_144941_5 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000023 288.0
TLS2_k127_144941_6 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000008494 244.0
TLS2_k127_144941_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000187 131.0
TLS2_k127_144941_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000003225 123.0
TLS2_k127_144941_9 Polymer-forming cytoskeletal - - - 0.0000000000000000000003001 104.0
TLS2_k127_14763_0 amino acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005997 322.0
TLS2_k127_14763_1 methionine synthase K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000017 226.0
TLS2_k127_14763_2 photoreceptor activity K11527 - 2.7.13.3 0.0006343 43.0
TLS2_k127_1504630_0 TRAP dicarboxylate transporter, DctP subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 361.0
TLS2_k127_1504630_1 Trap-type c4-dicarboxylate transport system, small permease component K11689 - - 0.000000000000000000000000000001638 126.0
TLS2_k127_1533790_0 type I restriction-modification system K03427 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003473 309.0
TLS2_k127_1533790_1 Amidohydrolase K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000269 277.0
TLS2_k127_1533790_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000001055 104.0
TLS2_k127_1533790_3 hydroperoxide reductase activity K07486 - - 0.000000000002818 69.0
TLS2_k127_1533790_4 NMT1-like family - - - 0.00000001176 66.0
TLS2_k127_1548832_0 acetyl-coa acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 316.0
TLS2_k127_1548832_1 Ornithine cyclodeaminase K01750 - 4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000001046 243.0
TLS2_k127_1548832_2 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.000000000000000000000000000001994 130.0
TLS2_k127_1598402_0 Tripartite tricarboxylate transporter TctA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006377 497.0
TLS2_k127_1598402_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009756 481.0
TLS2_k127_1598402_2 PFAM CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008093 272.0
TLS2_k127_1598402_3 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000008395 174.0
TLS2_k127_1598402_4 CoA-transferase family III - - - 0.000000000000000000000000000006486 124.0
TLS2_k127_1598402_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000002631 74.0
TLS2_k127_1598402_6 Tripartite tricarboxylate transporter TctA family - - - 0.000004248 56.0
TLS2_k127_1632473_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 454.0
TLS2_k127_1632473_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 431.0
TLS2_k127_1632473_10 protein conserved in bacteria - - - 0.00000000000000003633 94.0
TLS2_k127_1632473_11 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.0000000000008189 74.0
TLS2_k127_1632473_2 Rieske (2fe-2S) K15060 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007575 310.0
TLS2_k127_1632473_3 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004828 305.0
TLS2_k127_1632473_4 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000005184 257.0
TLS2_k127_1632473_5 O-methyltransferase - - - 0.00000000000000000000000000000000001786 141.0
TLS2_k127_1632473_6 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000004924 129.0
TLS2_k127_1632473_7 nucleotidyltransferase activity K07075 - - 0.0000000000000000000001016 100.0
TLS2_k127_1632473_8 sequence-specific DNA binding - - - 0.000000000000000000002057 99.0
TLS2_k127_1632473_9 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.000000000000000006068 88.0
TLS2_k127_1693965_0 Protein of unknown function (DUF1254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 332.0
TLS2_k127_1693965_1 PFAM extracellular solute-binding protein family 3 K02030,K09969,K10001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009334 284.0
TLS2_k127_1693965_2 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000000000000000000000000000000000000000000000000000000002175 230.0
TLS2_k127_1693965_3 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.000000000000003107 87.0
TLS2_k127_170005_0 PFAM FAD dependent oxidoreductase K09835,K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,5.2.1.13 1.133e-217 687.0
TLS2_k127_170005_1 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000001606 271.0
TLS2_k127_170005_2 Carotenoid biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000001275 201.0
TLS2_k127_170005_3 Belongs to the FPP GGPP synthase family - - - 0.00000000000000000000000000000000000000000000000000006507 202.0
TLS2_k127_170005_4 cobalamin binding K22491 - - 0.00000000000000108 86.0
TLS2_k127_170005_5 Helix-turn-helix XRE-family like proteins - - - 0.000000188 61.0
TLS2_k127_172015_0 Phosphoglucose isomerase K00616,K13810 - 2.2.1.2,5.3.1.9 1.304e-306 966.0
TLS2_k127_172015_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 2.738e-248 783.0
TLS2_k127_172015_2 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007247 582.0
TLS2_k127_172015_3 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 404.0
TLS2_k127_172015_4 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000003262 199.0
TLS2_k127_172015_5 Glucokinase K00845 - 2.7.1.2 0.000000000000000000008964 94.0
TLS2_k127_172015_6 protein conserved in bacteria K09931 - - 0.000000000002243 70.0
TLS2_k127_1776109_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 1.934e-291 918.0
TLS2_k127_1776109_1 Lon protease (S16) C-terminal proteolytic domain K01338 - 3.4.21.53 1.793e-287 904.0
TLS2_k127_1776109_10 von Willebrand factor, type A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001304 284.0
TLS2_k127_1776109_11 ABC-3 protein K09816,K09819 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005629 260.0
TLS2_k127_1776109_12 quinone binding K12057,K22278 - 3.5.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000007294 249.0
TLS2_k127_1776109_13 PFAM ABC transporter related K09817 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006797 246.0
TLS2_k127_1776109_14 Opacity-associated protein A LysM-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001402 250.0
TLS2_k127_1776109_15 Glutathione S-transferase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003118 229.0
TLS2_k127_1776109_16 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.00000000000000000000000000000000000000000000000000000000004014 210.0
TLS2_k127_1776109_17 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000005599 219.0
TLS2_k127_1776109_18 Domain of unknown function (DUF4198) - - - 0.00000000000000000000000000000000000000000000007137 178.0
TLS2_k127_1776109_19 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000002289 171.0
TLS2_k127_1776109_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.288e-256 799.0
TLS2_k127_1776109_20 protein some members contain a von Willebrand factor type A - - - 0.000000000000000000000000000000000000000008511 165.0
TLS2_k127_1776109_21 SCO1/SenC K07152,K08976 - - 0.000000000000000000000000000000000000000039 159.0
TLS2_k127_1776109_22 PFAM electron transport protein SCO1 SenC K07152 - - 0.000000000000000000000000000000000000001447 154.0
TLS2_k127_1776109_23 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000001229 147.0
TLS2_k127_1776109_24 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000000000000000000000000233 154.0
TLS2_k127_1776109_25 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000002346 139.0
TLS2_k127_1776109_26 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000009428 135.0
TLS2_k127_1776109_27 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000009652 139.0
TLS2_k127_1776109_28 SCO1/SenC K07152 - - 0.000000000000000000000000000000004978 135.0
TLS2_k127_1776109_29 Belongs to the small heat shock protein (HSP20) family - - - 0.00000000000000000000000000000008983 128.0
TLS2_k127_1776109_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 517.0
TLS2_k127_1776109_30 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.0000000000000000000000000000007457 129.0
TLS2_k127_1776109_31 von Willebrand factor, type A - - - 0.000000000000000000000000002109 129.0
TLS2_k127_1776109_32 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000001781 109.0
TLS2_k127_1776109_33 PFAM FmdE, Molybdenum formylmethanofuran dehydrogenase operon - - - 0.000000000000000000000007535 109.0
TLS2_k127_1776109_34 RecX family K03565 - - 0.0000000000000000005266 93.0
TLS2_k127_1776109_35 Cytochrome c K12263 - - 0.0000000000000008375 83.0
TLS2_k127_1776109_36 Periplasmic protein TonB links inner and outer membranes - - - 0.00000000002245 74.0
TLS2_k127_1776109_37 COG0607 Rhodanese-related sulfurtransferase - - - 0.00000001026 57.0
TLS2_k127_1776109_38 PFAM Cytochrome c oxidase assembly protein CtaG Cox11 K02258 - - 0.000002103 59.0
TLS2_k127_1776109_39 PFAM Rhodanese domain protein - - - 0.000003021 54.0
TLS2_k127_1776109_4 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 492.0
TLS2_k127_1776109_40 Domain of unknown function (DUF4382) - - - 0.0006045 51.0
TLS2_k127_1776109_5 PFAM peptidase S1 and S6 chymotrypsin Hap - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 438.0
TLS2_k127_1776109_6 AAA domain K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 430.0
TLS2_k127_1776109_7 Belongs to the bacterial solute-binding protein 9 family K02077,K09815,K09818 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004241 387.0
TLS2_k127_1776109_8 Belongs to the CinA family K03742,K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 317.0
TLS2_k127_1776109_9 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 295.0
TLS2_k127_182332_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 357.0
TLS2_k127_182332_1 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.000000000000000000000000000000000000000000000000000000002537 211.0
TLS2_k127_182332_2 Protein of unknown function (DUF2721) - - - 0.000000000000000000000000000000000000000001549 160.0
TLS2_k127_182332_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 GO:0003674,GO:0003824,GO:0003861,GO:0016829,GO:0016835,GO:0016836 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000004215 148.0
TLS2_k127_182332_4 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000001218 131.0
TLS2_k127_185241_0 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 372.0
TLS2_k127_185241_1 - - - - 0.000000000000000000000000000000000000000000001812 177.0
TLS2_k127_185241_2 WHG domain - - - 0.00000000000000000000000000000000000001187 152.0
TLS2_k127_185241_3 Domain of unknown function (DUF4281) - - - 0.000000000000000000000000000000005083 132.0
TLS2_k127_1868216_0 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001978 283.0
TLS2_k127_1868216_1 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000002202 220.0
TLS2_k127_1891918_0 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 511.0
TLS2_k127_1891918_1 PFAM helix-turn-helix, AraC type ThiJ PfpI - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006534 407.0
TLS2_k127_1891918_2 Kelch repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000003733 223.0
TLS2_k127_1891918_3 protein conserved in bacteria - - - 0.0000000000000000000004164 107.0
TLS2_k127_1891918_4 Bacterial protein of unknown function (DUF924) - - - 0.0000000003685 64.0
TLS2_k127_1893956_0 Isochorismatase hydrolase - - - 0.000000000000000000000000000000000000000000000000000000004615 207.0
TLS2_k127_1893956_1 Creatinase/Prolidase N-terminal domain K01271 - 3.4.13.9 0.000000000000000000000000000000000002473 153.0
TLS2_k127_1893956_2 Ornithine cyclodeaminase K01750 - 4.3.1.12 0.0000000000002119 72.0
TLS2_k127_1893956_3 ornithine cyclodeaminase K01750,K19244 - 1.4.1.1,4.3.1.12 0.00003333 55.0
TLS2_k127_1923314_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 5.499e-246 769.0
TLS2_k127_1923314_1 FAD dependent oxidoreductase K09879 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000872 502.0
TLS2_k127_1923314_10 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000006616 112.0
TLS2_k127_1923314_12 PFAM Methyltransferase type K15256 - - 0.0000000000000002072 87.0
TLS2_k127_1923314_2 large terminal subunit' - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 377.0
TLS2_k127_1923314_3 4,5-dihydroxyphthalate decarboxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 318.0
TLS2_k127_1923314_4 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000001723 225.0
TLS2_k127_1923314_5 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000003194 200.0
TLS2_k127_1923314_6 lycopene cyclase - - - 0.0000000000000000000000000000000000000000000000000008555 194.0
TLS2_k127_1923314_7 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000005575 145.0
TLS2_k127_1923314_8 protein possibly involved in utilization of glycolate and propanediol - - - 0.00000000000000000000000000000000307 133.0
TLS2_k127_1923314_9 RHS Repeat - - - 0.000000000000000000000000008915 128.0
TLS2_k127_1930157_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 609.0
TLS2_k127_1930157_1 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005201 540.0
TLS2_k127_1930157_10 Protein of unknown function (DUF3303) - - - 0.00000000000000000000000000000000000000000000000000000006515 196.0
TLS2_k127_1930157_11 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000005437 194.0
TLS2_k127_1930157_12 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate K02437 GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 - 0.0000000000000000000000000000000000000000000004908 170.0
TLS2_k127_1930157_13 ECF sigma factor - - - 0.0000000000000000000000000000000000000002776 156.0
TLS2_k127_1930157_14 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.00000000000000000000000000000000000001424 158.0
TLS2_k127_1930157_15 Molybdopterin converting factor, small subunit K03636 - - 0.0000000000000000000000000000000002903 133.0
TLS2_k127_1930157_16 Nitroreductase family - - - 0.000000000000000000000000000005052 126.0
TLS2_k127_1930157_17 Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - - 0.0000000000001234 73.0
TLS2_k127_1930157_18 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000005584 70.0
TLS2_k127_1930157_19 TIGRFAM TonB K03832 - - 0.000000000002862 76.0
TLS2_k127_1930157_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006054 449.0
TLS2_k127_1930157_20 NIL - - - 0.000000000007981 68.0
TLS2_k127_1930157_21 - - - - 0.0000000004902 68.0
TLS2_k127_1930157_22 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000009682 56.0
TLS2_k127_1930157_23 Putative zinc-finger - - - 0.0000003437 59.0
TLS2_k127_1930157_24 Protein of unknown function (DUF3426) - - - 0.0000006352 61.0
TLS2_k127_1930157_25 decarboxylase K01607 - 4.1.1.44 0.0000179 53.0
TLS2_k127_1930157_3 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 396.0
TLS2_k127_1930157_4 Belongs to the cysteine synthase cystathionine beta- synthase family K01883,K12339 - 2.5.1.47,6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 374.0
TLS2_k127_1930157_5 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 366.0
TLS2_k127_1930157_6 Belongs to the UPF0255 family K11750 GO:0003674,GO:0003824,GO:0005575,GO:0006109,GO:0006629,GO:0008150,GO:0008152,GO:0009894,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0019222,GO:0043470,GO:0044238,GO:0050789,GO:0065007,GO:0071704,GO:0080090 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 318.0
TLS2_k127_1930157_7 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 310.0
TLS2_k127_1930157_8 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 287.0
TLS2_k127_1930157_9 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively K04099,K04101 - 1.13.11.57,1.13.11.8 0.000000000000000000000000000000000000000000000000000000000000005528 225.0
TLS2_k127_1930728_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1792.0
TLS2_k127_1930728_1 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 6.13e-265 835.0
TLS2_k127_1930728_10 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 353.0
TLS2_k127_1930728_11 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00042 - 1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 337.0
TLS2_k127_1930728_12 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009665 320.0
TLS2_k127_1930728_13 phosphorelay signal transduction system K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 329.0
TLS2_k127_1930728_14 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005669 272.0
TLS2_k127_1930728_15 Lysin motif K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000001459 236.0
TLS2_k127_1930728_16 Domains HAMP, HisKA, HATPase_c, REC K02030 - - 0.000000000000000000000000000000000000000000000000000000000000001885 241.0
TLS2_k127_1930728_17 PFAM FAD linked oxidase domain protein K11472 - - 0.00000000000000000000000000000000000000000000000000000000000001238 233.0
TLS2_k127_1930728_18 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000004757 212.0
TLS2_k127_1930728_19 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000002667 197.0
TLS2_k127_1930728_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.383e-244 774.0
TLS2_k127_1930728_20 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000004432 200.0
TLS2_k127_1930728_21 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000004407 189.0
TLS2_k127_1930728_22 anaphase-promoting complex-dependent catabolic process - - - 0.000000000000000000000000000000000000000000000002955 180.0
TLS2_k127_1930728_23 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.00000000000000000000000000000000000000000007832 170.0
TLS2_k127_1930728_24 DNA mediated transformation - - - 0.000000000000000000000000000000000000000005825 160.0
TLS2_k127_1930728_25 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000007883 160.0
TLS2_k127_1930728_26 PFAM amidohydrolase K07045 - - 0.0000000000000000000000000000000000001942 154.0
TLS2_k127_1930728_27 coenzyme F420-1:gamma-L-glutamate ligase activity K04719 - 1.13.11.79 0.0000000000000000000000005485 113.0
TLS2_k127_1930728_28 Protein of unknown function (DUF983) - - - 0.0000000000000000000001259 102.0
TLS2_k127_1930728_29 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000003861 105.0
TLS2_k127_1930728_3 Transglycosylase - - - 5.85e-241 781.0
TLS2_k127_1930728_30 - - - - 0.000000000000000000002703 97.0
TLS2_k127_1930728_31 protein conserved in bacteria - - - 0.000000000000000000002863 96.0
TLS2_k127_1930728_32 NMT1-like family K02051 - - 0.00000000000000002498 93.0
TLS2_k127_1930728_33 NMT1-like family - - - 0.000000000001921 79.0
TLS2_k127_1930728_34 Iron-containing redox enzyme K06137 - 1.3.3.11 0.0000000002666 69.0
TLS2_k127_1930728_35 ABC transporter, substrate-binding protein, aliphatic sulfonates family K15553 - - 0.00000025 62.0
TLS2_k127_1930728_37 Cupin domain - - - 0.000003051 55.0
TLS2_k127_1930728_38 4Fe-4S binding domain K00395,K02572,K03616 - 1.8.99.2 0.000003829 57.0
TLS2_k127_1930728_39 Transcription factor zinc-finger K09981 - - 0.00001955 52.0
TLS2_k127_1930728_4 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000299 588.0
TLS2_k127_1930728_40 Translation Initiation Inhibitor YjgF Family - - - 0.0002569 51.0
TLS2_k127_1930728_5 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 537.0
TLS2_k127_1930728_6 PFAM FAD linked oxidase domain protein K00102,K00104 - 1.1.2.4,1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 518.0
TLS2_k127_1930728_7 Binding-protein-dependent transport system inner membrane component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 501.0
TLS2_k127_1930728_8 Tripartite tricarboxylate transporter TctA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 485.0
TLS2_k127_1930728_9 4Fe-4S dicluster domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000744 412.0
TLS2_k127_193085_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1306.0
TLS2_k127_193085_1 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003659 507.0
TLS2_k127_193085_10 - - - - 0.00000001178 61.0
TLS2_k127_193085_11 Alpha/beta hydrolase of unknown function (DUF900) - - - 0.000003242 53.0
TLS2_k127_193085_2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 344.0
TLS2_k127_193085_3 Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 300.0
TLS2_k127_193085_4 peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001092 280.0
TLS2_k127_193085_5 Alpha/beta hydrolase of unknown function (DUF900) - - - 0.00000000000000000000000000000000000000000000000000001798 194.0
TLS2_k127_193085_6 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000000000001894 181.0
TLS2_k127_193085_7 Alpha/beta hydrolase of unknown function (DUF900) - - - 0.00000000000000000000000000000000000000001693 161.0
TLS2_k127_193085_8 Iron-containing redox enzyme K06137 - 1.3.3.11 0.00000000000000000000000000000000000000002788 161.0
TLS2_k127_193085_9 Amidohydrolase K07045 - - 0.00000000003403 64.0
TLS2_k127_1939805_0 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002676 237.0
TLS2_k127_1939805_1 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000001496 244.0
TLS2_k127_1939805_2 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000000000000000000000000004846 160.0
TLS2_k127_1939805_3 - - - - 0.00000000000000000000000000000003839 126.0
TLS2_k127_1939805_5 Outer membrane protein beta-barrel domain K16079 - - 0.0000000000000000000296 102.0
TLS2_k127_2019216_0 glycosylase i K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 315.0
TLS2_k127_2019216_1 COG0563 Adenylate kinase and related kinases - - - 0.0000000000000000000000000000000000000000000000000000000000000006126 229.0
TLS2_k127_2019216_2 Belongs to the GcvT family K06980 - - 0.000000000000000000000000001979 114.0
TLS2_k127_2019216_3 Metal dependent phosphohydrolases with conserved 'HD' motif. K06952 - - 0.00000000000000000000002582 105.0
TLS2_k127_2019216_4 Protein of unknown function (DUF3126) - - - 0.00000003471 63.0
TLS2_k127_2074538_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009685 447.0
TLS2_k127_2074538_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 327.0
TLS2_k127_2074538_2 acetylesterase activity K01046 - 3.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000354 242.0
TLS2_k127_2074538_3 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000000000000001845 179.0
TLS2_k127_2074538_4 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.0000000000000000000000000000000000000000000005029 172.0
TLS2_k127_2074538_5 NMT1-like family K02051,K15551 - - 0.00004701 55.0
TLS2_k127_2074985_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 6.999e-282 878.0
TLS2_k127_2074985_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 6.266e-240 753.0
TLS2_k127_2074985_10 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 423.0
TLS2_k127_2074985_11 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 423.0
TLS2_k127_2074985_12 MiaB-like tRNA modifying enzyme K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 409.0
TLS2_k127_2074985_13 Two component, sigma54 specific, transcriptional regulator, Fis family K02667,K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008351 370.0
TLS2_k127_2074985_14 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005095 349.0
TLS2_k127_2074985_15 ABC transporter K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007799 300.0
TLS2_k127_2074985_16 conserved protein (COG2071) K09166 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 298.0
TLS2_k127_2074985_17 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 297.0
TLS2_k127_2074985_18 NMT1/THI5 like K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 296.0
TLS2_k127_2074985_19 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006373 290.0
TLS2_k127_2074985_2 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 3.78e-222 696.0
TLS2_k127_2074985_20 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002309 280.0
TLS2_k127_2074985_21 Belongs to the peptidase S51 family K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002348 280.0
TLS2_k127_2074985_22 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000003783 280.0
TLS2_k127_2074985_23 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000000000000000000000000000000000000000000000000000000000000000000002408 261.0
TLS2_k127_2074985_24 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000002745 263.0
TLS2_k127_2074985_25 Binding-protein-dependent transport system inner membrane component K02050,K15599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000787 249.0
TLS2_k127_2074985_26 PFAM Glycine sarcosine betaine reductase component B subunits - - - 0.000000000000000000000000000000000000000000000000000000000000000001491 244.0
TLS2_k127_2074985_27 cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000009459 217.0
TLS2_k127_2074985_28 DoxX K15977,K16937 - 1.8.5.2 0.00000000000000000000000000000000000000000000000000000000002048 211.0
TLS2_k127_2074985_29 cytochrome c nitrite reductase K15876 - - 0.0000000000000000000000000000000000000000000000000000000002093 206.0
TLS2_k127_2074985_3 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 2.358e-210 669.0
TLS2_k127_2074985_30 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000442 211.0
TLS2_k127_2074985_31 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.0000000000000000000000000000000000000000000000000000002014 209.0
TLS2_k127_2074985_32 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000002228 190.0
TLS2_k127_2074985_33 hydrolase, TatD family' K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000006722 157.0
TLS2_k127_2074985_34 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000000000000000008467 143.0
TLS2_k127_2074985_35 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000000000000000000000000000001002 127.0
TLS2_k127_2074985_36 IMP dehydrogenase activity - - - 0.000000000000000000000000000005918 123.0
TLS2_k127_2074985_37 protein conserved in bacteria - - - 0.000000000000000000000000006061 124.0
TLS2_k127_2074985_38 IMP dehydrogenase activity K04767 - - 0.00000000000000000000000003328 114.0
TLS2_k127_2074985_39 YbbR-like protein - - - 0.0000000000000000000001422 110.0
TLS2_k127_2074985_4 COG1053 Succinate dehydrogenase fumarate reductase, flavoprotein subunit - - - 2.075e-205 654.0
TLS2_k127_2074985_40 - - - - 0.0000000000004995 77.0
TLS2_k127_2074985_43 Protein of unknown function, DUF393 - - - 0.0001527 46.0
TLS2_k127_2074985_44 transferase activity, transferring glycosyl groups - - - 0.0002417 50.0
TLS2_k127_2074985_5 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 552.0
TLS2_k127_2074985_6 radical SAM K06871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 519.0
TLS2_k127_2074985_7 PFAM aspartate glutamate uridylate kinase K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 499.0
TLS2_k127_2074985_8 TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type I K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 462.0
TLS2_k127_2074985_9 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 467.0
TLS2_k127_2075445_0 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 437.0
TLS2_k127_2075445_1 Mechanosensitive ion channel K03442 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 375.0
TLS2_k127_2075445_10 NMT1-like family K02051 - - 0.0000000000007439 81.0
TLS2_k127_2075445_2 Selenoprotein B, glycine betaine sarcosine D-proline reductase family K10672 - 1.21.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 304.0
TLS2_k127_2075445_3 PFAM Oxidoreductase molybdopterin binding domain K07147 - - 0.00000000000000000000000000000000000000000000000000000000008076 205.0
TLS2_k127_2075445_4 Pfam Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000002418 213.0
TLS2_k127_2075445_5 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000008823 197.0
TLS2_k127_2075445_6 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000002387 195.0
TLS2_k127_2075445_7 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.00000000000000000000000000000000000000000000000004022 191.0
TLS2_k127_2075445_8 glycine betaine sarcosine D-proline reductase family K10672 - 1.21.4.2 0.00000000000000000000746 94.0
TLS2_k127_2075445_9 PFAM Glycine sarcosine betaine reductase component B subunits - - - 0.0000000000000000002103 91.0
TLS2_k127_2094985_0 Sugar (and other) transporter K08178 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005206 363.0
TLS2_k127_2094985_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 324.0
TLS2_k127_2094985_10 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.000000000001824 73.0
TLS2_k127_2094985_11 thiamine-containing compound biosynthetic process K02051,K15553 - - 0.00000000001798 76.0
TLS2_k127_2094985_12 Cupin domain - - - 0.00009515 50.0
TLS2_k127_2094985_2 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 289.0
TLS2_k127_2094985_3 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000001815 256.0
TLS2_k127_2094985_4 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001159 263.0
TLS2_k127_2094985_5 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002649 244.0
TLS2_k127_2094985_6 aldo keto reductase K05275 - 1.1.1.65 0.000000000000000000000000000000000000000000000000001462 184.0
TLS2_k127_2094985_7 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0000000000000000000000000000000003844 133.0
TLS2_k127_2094985_8 PFAM aldo keto reductase - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0055114 - 0.000000000000000000003779 95.0
TLS2_k127_2094985_9 Iron-binding zinc finger CDGSH type - - - 0.000000000000004878 79.0
TLS2_k127_2103217_0 PFAM FAD linked oxidase domain protein - - - 1.377e-311 983.0
TLS2_k127_2103217_1 ATP-binding region, ATPase domain protein domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 376.0
TLS2_k127_2103217_11 Pfam:Pyridox_oxidase - - - 0.00000000000000000000000000001317 122.0
TLS2_k127_2103217_12 Type III restriction enzyme res subunit K01156 - 3.1.21.5 0.000000000000000000000000001948 118.0
TLS2_k127_2103217_13 PFAM Transglycosylase-associated protein - - - 0.00000000000000000000000004471 110.0
TLS2_k127_2103217_14 Barstar (barnase inhibitor) - - - 0.00000000000000000000002146 104.0
TLS2_k127_2103217_15 photosystem II stabilization K02237 - - 0.000000000000000000000769 100.0
TLS2_k127_2103217_16 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000003001 83.0
TLS2_k127_2103217_17 CarD family transcriptional regulator K07736 GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496 - 0.0000000001243 70.0
TLS2_k127_2103217_18 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - 0.00003883 53.0
TLS2_k127_2103217_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 301.0
TLS2_k127_2103217_3 deaminated base DNA N-glycosylase activity K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002541 280.0
TLS2_k127_2103217_4 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0016829,GO:0016835,GO:0016838,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000003118 265.0
TLS2_k127_2103217_5 Diguanylate cyclase K21023 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000003988 214.0
TLS2_k127_2103217_6 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000079 191.0
TLS2_k127_2103217_7 Ribonuclease K01167 - 3.1.27.3 0.0000000000000000000000000000000000005831 143.0
TLS2_k127_2103217_8 DNA methylase K07316 - 2.1.1.72 0.000000000000000000000000000000000003094 145.0
TLS2_k127_2103217_9 cheY-homologous receiver domain - - - 0.000000000000000000000000000000005882 132.0
TLS2_k127_2107790_0 Phosphate acyltransferases K05939 - 2.3.1.40,6.2.1.20 0.0 1141.0
TLS2_k127_2107790_1 Domain of Unknown Function (DUF748) - - - 9.947e-252 820.0
TLS2_k127_2107790_10 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000006057 237.0
TLS2_k127_2107790_11 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000001193 229.0
TLS2_k127_2107790_12 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components - - - 0.00000000000000000000000000000000000000000000000000000000000000196 229.0
TLS2_k127_2107790_13 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000001245 219.0
TLS2_k127_2107790_14 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000008601 223.0
TLS2_k127_2107790_15 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000004011 205.0
TLS2_k127_2107790_16 ABC-type nitrate sulfonate bicarbonate transport system permease component - - - 0.00000000000000000000000000000000000000000001336 174.0
TLS2_k127_2107790_17 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000002109 177.0
TLS2_k127_2107790_18 intermembrane phospholipid transfer K07323 - - 0.0000000000000000000000000000005555 129.0
TLS2_k127_2107790_19 PFAM AIG2 family protein - - - 0.0000000000000000000000002526 110.0
TLS2_k127_2107790_2 GH3 auxin-responsive promoter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 452.0
TLS2_k127_2107790_20 Zincin-like metallopeptidase - - - 0.0000000000000000000000005166 108.0
TLS2_k127_2107790_21 - - - - 0.0000000000000000000176 93.0
TLS2_k127_2107790_22 Iron-containing redox enzyme - - - 0.000000000000000001234 100.0
TLS2_k127_2107790_23 Psort location Cytoplasmic, score - - - 0.0000000000000007812 83.0
TLS2_k127_2107790_24 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.0000000000001542 73.0
TLS2_k127_2107790_3 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 400.0
TLS2_k127_2107790_4 ornithine cyclodeaminase K01750 - 4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008805 349.0
TLS2_k127_2107790_5 MltA specific insert domain K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 317.0
TLS2_k127_2107790_6 COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002242 270.0
TLS2_k127_2107790_7 carboxylic acid catabolic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002029 281.0
TLS2_k127_2107790_8 Belongs to the UbiD family K16874 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003044 274.0
TLS2_k127_2107790_9 cation diffusion facilitator family transporter K16264 GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001271 257.0
TLS2_k127_2160022_0 Dehydrogenase E1 component K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 370.0
TLS2_k127_2160022_1 PFAM Transketolase central region K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 369.0
TLS2_k127_2160022_2 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162,K11381 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000685 346.0
TLS2_k127_2160022_3 PFAM dehydrogenase, E1 component K21416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 299.0
TLS2_k127_2160022_4 F420-dependent oxidoreductase, MSMEG_3544 family - - - 0.00000000000000000000000000000000000000000000000000000002311 208.0
TLS2_k127_2160022_5 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000001524 163.0
TLS2_k127_2160022_6 Cupin domain - - - 0.0000000000000000000000000000006127 127.0
TLS2_k127_2160022_7 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000007622 109.0
TLS2_k127_2160022_8 N-4 methylation of cytosine K00571 - 2.1.1.72 0.0000000000000009663 79.0
TLS2_k127_2183712_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 594.0
TLS2_k127_2183712_1 Ferric uptake regulator family K03711,K09825 - - 0.0000000000000000000000000000000000006592 147.0
TLS2_k127_2183712_2 CHASE2 K01768 - 4.6.1.1 0.000000000000000000000000000000000139 142.0
TLS2_k127_2183712_3 serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 0.00000000000000000000538 94.0
TLS2_k127_2183712_4 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000001478 63.0
TLS2_k127_2226976_0 pyruvate dehydrogenase (acetyl-transferring) activity K00163 - 1.2.4.1 0.0 1167.0
TLS2_k127_2226976_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1050.0
TLS2_k127_2226976_10 general L-amino acid-binding periplasmic protein AapJ K09969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 486.0
TLS2_k127_2226976_11 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 474.0
TLS2_k127_2226976_12 COG0765 ABC-type amino acid transport system, permease component K09971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007442 444.0
TLS2_k127_2226976_13 Dimerisation domain of Zinc Transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006743 395.0
TLS2_k127_2226976_14 Gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 392.0
TLS2_k127_2226976_15 acid transport system permease K09970 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008522 370.0
TLS2_k127_2226976_16 nitric oxide reductase activity K03809 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 346.0
TLS2_k127_2226976_17 Peptidase family M28 K01258 - 3.4.11.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005343 351.0
TLS2_k127_2226976_18 COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 342.0
TLS2_k127_2226976_19 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004326 342.0
TLS2_k127_2226976_2 CoA-binding domain protein - - - 0.0 1034.0
TLS2_k127_2226976_20 Component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000996 349.0
TLS2_k127_2226976_21 ornithine cyclodeaminase K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 336.0
TLS2_k127_2226976_22 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007752 293.0
TLS2_k127_2226976_23 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 291.0
TLS2_k127_2226976_24 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 289.0
TLS2_k127_2226976_25 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001621 269.0
TLS2_k127_2226976_26 PFAM Cytochrome c, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002637 269.0
TLS2_k127_2226976_27 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000003649 259.0
TLS2_k127_2226976_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000002448 250.0
TLS2_k127_2226976_29 TIM-barrel fold metal-dependent hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002929 255.0
TLS2_k127_2226976_3 Belongs to the TPP enzyme family K01652 - 2.2.1.6 2.319e-271 844.0
TLS2_k127_2226976_30 Peptidase M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000006261 250.0
TLS2_k127_2226976_31 HTH domain K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000006783 234.0
TLS2_k127_2226976_32 Divergent AAA domain protein K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000009165 237.0
TLS2_k127_2226976_33 tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000001998 228.0
TLS2_k127_2226976_34 COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs K00087,K03519 - 1.17.1.4,1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000002293 225.0
TLS2_k127_2226976_35 Dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000504 214.0
TLS2_k127_2226976_36 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000005554 211.0
TLS2_k127_2226976_37 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.5.99.2 0.000000000000000000000000000000000000000000000000000007674 198.0
TLS2_k127_2226976_38 Polyprenyl synthetase K02523,K13787 GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.0000000000000000000000000000000000000000000000000001959 198.0
TLS2_k127_2226976_39 tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000003297 194.0
TLS2_k127_2226976_4 Elongation factor Tu domain 2 K02355 - - 1.292e-226 728.0
TLS2_k127_2226976_40 Serine aminopeptidase, S33 K06889 - - 0.000000000000000000000000000000000000000000000000001065 195.0
TLS2_k127_2226976_41 Tripartite tricarboxylate transporter family receptor K07795 - - 0.000000000000000000000000000000000000000000000000006789 193.0
TLS2_k127_2226976_42 PFAM Biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.0000000000000000000000000000000000000000000000003528 184.0
TLS2_k127_2226976_43 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000004727 176.0
TLS2_k127_2226976_44 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000012 184.0
TLS2_k127_2226976_45 Calcineurin-like phosphoesterase K07313 - 3.1.3.16 0.000000000000000000000000000000000000000000000082 177.0
TLS2_k127_2226976_46 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.0000000000000000000000000000000000000000000002398 181.0
TLS2_k127_2226976_47 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.0000000000000000000000000000000000000000000007299 172.0
TLS2_k127_2226976_48 Regulatory protein GntR HTH K05799 - - 0.000000000000000000000000000000000000000000001336 173.0
TLS2_k127_2226976_49 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000142 171.0
TLS2_k127_2226976_5 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate K07749 - 2.8.3.16 3.615e-197 621.0
TLS2_k127_2226976_50 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000000000001736 158.0
TLS2_k127_2226976_51 PFAM YeeE YedE family (DUF395) K07112 - - 0.00000000000000000000000000000000000000001926 159.0
TLS2_k127_2226976_52 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000002064 164.0
TLS2_k127_2226976_53 PFAM FxsA cytoplasmic membrane protein K07113 - - 0.0000000000000000000000000000000000001957 145.0
TLS2_k127_2226976_54 - - - - 0.0000000000000000000000000000000000001976 144.0
TLS2_k127_2226976_55 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000001136 138.0
TLS2_k127_2226976_56 protein conserved in bacteria - - - 0.000000000000000000000000000006414 125.0
TLS2_k127_2226976_57 transporter component K07112 - - 0.00000000000000000000000000001533 123.0
TLS2_k127_2226976_58 - - - - 0.000000000000000000000000008184 113.0
TLS2_k127_2226976_59 Cold shock protein K03704 - - 0.00000000000000000000000001189 113.0
TLS2_k127_2226976_6 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 559.0
TLS2_k127_2226976_60 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000012 109.0
TLS2_k127_2226976_61 - - - - 0.000000000000000000001561 99.0
TLS2_k127_2226976_62 Helix-turn-helix K21498 - - 0.000000000000000000001608 96.0
TLS2_k127_2226976_63 Endoribonuclease L-PSP - - - 0.000000000000000000141 102.0
TLS2_k127_2226976_64 oxidase subunit K08738 - - 0.000000000000000002998 99.0
TLS2_k127_2226976_65 Glyoxalase-like domain - - - 0.00000000000000002118 87.0
TLS2_k127_2226976_66 Cupin 2, conserved barrel domain protein K00971,K01809,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000007327 87.0
TLS2_k127_2226976_67 PFAM amidohydrolase - - - 0.0000000000000005355 90.0
TLS2_k127_2226976_68 - - - - 0.00000000000001992 75.0
TLS2_k127_2226976_69 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000002216 82.0
TLS2_k127_2226976_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000058 522.0
TLS2_k127_2226976_70 Hydantoin racemase K16841 - 5.1.99.3 0.0000000000001231 80.0
TLS2_k127_2226976_71 - - - - 0.000000000003065 76.0
TLS2_k127_2226976_72 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.00000000004207 72.0
TLS2_k127_2226976_73 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.0000000001396 72.0
TLS2_k127_2226976_74 2Fe-2S -binding domain - - - 0.00000002255 59.0
TLS2_k127_2226976_75 - - - - 0.000005039 57.0
TLS2_k127_2226976_78 Glyoxalase-like domain K08234 - - 0.0001148 54.0
TLS2_k127_2226976_79 Hsp90 protein K04079 - - 0.0001161 55.0
TLS2_k127_2226976_8 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004376 502.0
TLS2_k127_2226976_80 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0001764 46.0
TLS2_k127_2226976_81 COG2010 Cytochrome c, mono- and diheme variants - - - 0.0005687 47.0
TLS2_k127_2226976_9 Tripartite tricarboxylate transporter TctA family K07793 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 490.0
TLS2_k127_2229479_0 PFAM Conserved region in glutamate synthase K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.7.1 0.0 2173.0
TLS2_k127_2229479_1 Glutamate synthase K00266 - 1.4.1.13,1.4.1.14 2.248e-252 785.0
TLS2_k127_2229479_10 Yqey-like protein K09117 - - 0.00000000000000000000000000000000001697 141.0
TLS2_k127_2229479_11 Polyprenyl synthetase K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000001913 137.0
TLS2_k127_2229479_12 thiolester hydrolase activity K19188 - 3.7.1.19 0.000000000000000000000000000001722 123.0
TLS2_k127_2229479_13 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000001718 95.0
TLS2_k127_2229479_14 thiolester hydrolase activity K19188 - 3.7.1.19 0.00000000000000000009855 91.0
TLS2_k127_2229479_15 Colicin V production protein K03558 - - 0.00000000000000395 83.0
TLS2_k127_2229479_16 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0003118 51.0
TLS2_k127_2229479_17 thiolester hydrolase activity K19188 - 3.7.1.19 0.0003284 46.0
TLS2_k127_2229479_18 thiolester hydrolase activity K19188 - 3.7.1.19 0.0003688 44.0
TLS2_k127_2229479_2 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 6.374e-221 706.0
TLS2_k127_2229479_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 630.0
TLS2_k127_2229479_4 Glutathione S-transferase K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 385.0
TLS2_k127_2229479_5 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 353.0
TLS2_k127_2229479_6 ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008234 288.0
TLS2_k127_2229479_7 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000001205 179.0
TLS2_k127_2229479_8 cystathionine K01739 - 2.5.1.48 0.000000000000000000000000000000000000000004713 156.0
TLS2_k127_2229479_9 helix_turn_helix ASNC type K03719 - - 0.0000000000000000000000000000000000002896 147.0
TLS2_k127_2248936_0 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000000000000000000000003221 226.0
TLS2_k127_2248936_1 peptidase - - - 0.0000000000000000000000000000000000000000000000000001708 199.0
TLS2_k127_2248936_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.000000000000000000000000000000000000000000000006227 180.0
TLS2_k127_2264648_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 571.0
TLS2_k127_2264648_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 543.0
TLS2_k127_2264648_10 DNA integration K14059 - - 0.0000005513 51.0
TLS2_k127_2264648_2 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 430.0
TLS2_k127_2264648_3 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006983 395.0
TLS2_k127_2264648_4 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000000000000006989 218.0
TLS2_k127_2264648_5 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000004587 201.0
TLS2_k127_2264648_6 TspO/MBR family K05770 - - 0.0000000000000000000000000000000000000000000001135 175.0
TLS2_k127_2264648_8 LysM domain - - - 0.00000000003707 76.0
TLS2_k127_2264648_9 Cupin domain - - - 0.00000001169 62.0
TLS2_k127_2276317_0 Adenylate - - - 3.731e-228 741.0
TLS2_k127_2276317_1 GMC oxidoreductase K00108 - 1.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005777 368.0
TLS2_k127_2276317_2 Catalase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006179 243.0
TLS2_k127_2276317_3 Domain of unknown function (DUF892) - - - 0.0000000000000000000000000000000000000000000000000000000000003482 215.0
TLS2_k127_2276317_4 - - - - 0.0000003245 57.0
TLS2_k127_2304398_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1499.0
TLS2_k127_2304398_1 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 8.394e-211 680.0
TLS2_k127_2304398_10 PFAM binding-protein-dependent transport systems inner membrane component K02042 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005085 372.0
TLS2_k127_2304398_11 Binding-protein-dependent transport system inner membrane component K02042 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003131 343.0
TLS2_k127_2304398_12 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 335.0
TLS2_k127_2304398_13 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008376 330.0
TLS2_k127_2304398_14 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K16874 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001832 283.0
TLS2_k127_2304398_15 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000003431 265.0
TLS2_k127_2304398_16 aspartate carbamoyltransferase activity K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000001562 268.0
TLS2_k127_2304398_17 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002329 244.0
TLS2_k127_2304398_18 Homoserine dehydrogenase, NAD binding domain K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000637 248.0
TLS2_k127_2304398_19 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000002697 228.0
TLS2_k127_2304398_2 PFAM aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 582.0
TLS2_k127_2304398_20 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000003227 223.0
TLS2_k127_2304398_21 Phosphoesterase K07095 - - 0.0000000000000000000000000000000000000000000000001461 181.0
TLS2_k127_2304398_22 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.4.2.9 0.000000000000000000000000000000000000000000005067 170.0
TLS2_k127_2304398_23 3-hydroxyanthranilic acid dioxygenase K00452 - 1.13.11.6 0.0000000000000000000000000000000000000007906 154.0
TLS2_k127_2304398_24 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000005796 86.0
TLS2_k127_2304398_25 COG0346 Lactoylglutathione lyase and related lyases K07032 - - 0.0000000000000000109 85.0
TLS2_k127_2304398_26 PFAM Rhomboid family protein - - - 0.000000000000003184 84.0
TLS2_k127_2304398_27 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K16049 - 1.13.11.25 0.0005217 52.0
TLS2_k127_2304398_3 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 597.0
TLS2_k127_2304398_4 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 520.0
TLS2_k127_2304398_5 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K16877 - 1.3.99.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 530.0
TLS2_k127_2304398_6 Proposed homoserine kinase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 482.0
TLS2_k127_2304398_7 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 434.0
TLS2_k127_2304398_8 TIGRFAM phosphonate ABC transporter, periplasmic phosphonate-binding protein K02044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 414.0
TLS2_k127_2304398_9 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05541 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 395.0
TLS2_k127_2316110_0 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009074 361.0
TLS2_k127_2316110_1 acetyl-coa acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005867 312.0
TLS2_k127_2316110_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000788 259.0
TLS2_k127_2316110_3 - - - - 0.00000000008108 62.0
TLS2_k127_2322848_0 amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008918 549.0
TLS2_k127_2322848_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008789 382.0
TLS2_k127_2322848_10 - - - - 0.0000000000000000000000000000000000002893 145.0
TLS2_k127_2322848_11 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000009178 130.0
TLS2_k127_2322848_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000008566 88.0
TLS2_k127_2322848_13 Cupin 2, conserved barrel domain protein K21700 - - 0.00000000000000001279 87.0
TLS2_k127_2322848_14 hemerythrin HHE cation binding domain - - - 0.000000000000007695 81.0
TLS2_k127_2322848_15 Transcription factor zinc-finger K09981 - - 0.000000000003986 70.0
TLS2_k127_2322848_16 DNA excision K02806 - - 0.0000000005207 63.0
TLS2_k127_2322848_17 bleomycin resistance protein - - - 0.000002317 55.0
TLS2_k127_2322848_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 352.0
TLS2_k127_2322848_3 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009395 338.0
TLS2_k127_2322848_4 abc transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008736 311.0
TLS2_k127_2322848_5 abc transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 305.0
TLS2_k127_2322848_6 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000006212 263.0
TLS2_k127_2322848_7 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000003361 221.0
TLS2_k127_2322848_8 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000000000001798 194.0
TLS2_k127_2322848_9 PAS domain - - - 0.00000000000000000000000000000000000001143 152.0
TLS2_k127_232959_0 Thiamine pyrophosphate enzyme, central domain - - - 3.532e-237 746.0
TLS2_k127_232959_1 Thiamine pyrophosphate enzyme, central domain - - - 1.133e-235 743.0
TLS2_k127_232959_10 Substrate binding domain of ABC-type glycine betaine transport system - - - 0.000000001011 70.0
TLS2_k127_232959_11 Tripartite tricarboxylate transporter TctB family - - - 0.000000005027 64.0
TLS2_k127_232959_2 MmgE/PrpD family - - - 4.622e-232 728.0
TLS2_k127_232959_3 Tripartite tricarboxylate transporter TctA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004761 559.0
TLS2_k127_232959_4 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 485.0
TLS2_k127_232959_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 329.0
TLS2_k127_232959_6 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001487 291.0
TLS2_k127_232959_7 NADP oxidoreductase coenzyme F420-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000000001846 244.0
TLS2_k127_232959_8 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000001563 106.0
TLS2_k127_232959_9 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000001327 85.0
TLS2_k127_2340008_0 Amidohydrolase K07045 - - 8.009e-254 791.0
TLS2_k127_2340008_1 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 441.0
TLS2_k127_2340008_10 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000005923 156.0
TLS2_k127_2340008_11 Domain of unknown function (DUF1989) K09967 - - 0.00000000000000000000000000000005011 135.0
TLS2_k127_2340008_12 Polysaccharide deacetylase - - - 0.00000000000000000000000000000192 133.0
TLS2_k127_2340008_13 Protein of unknown function (DUF3891) - - - 0.000000000000000000000001735 113.0
TLS2_k127_2340008_14 PFAM amidohydrolase K07045 - - 0.0000000000000000000006257 108.0
TLS2_k127_2340008_15 Domain of unknown function (DUF1989) K09967 - - 0.000000000000000000001795 102.0
TLS2_k127_2340008_16 PFAM Amidohydrolase 2 - - - 0.000000000002298 78.0
TLS2_k127_2340008_17 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.0000000005368 70.0
TLS2_k127_2340008_18 NMT1/THI5 like K02051 - - 0.000000002876 69.0
TLS2_k127_2340008_19 Transposase IS116/IS110/IS902 family - - - 0.00000003092 56.0
TLS2_k127_2340008_2 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 430.0
TLS2_k127_2340008_20 lactoylglutathione lyase activity K11210 - - 0.00000003335 64.0
TLS2_k127_2340008_21 NMT1-like family K02051 GO:0003674,GO:0005215 - 0.000008642 52.0
TLS2_k127_2340008_3 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 406.0
TLS2_k127_2340008_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 361.0
TLS2_k127_2340008_5 Acetyl xylan esterase (AXE1) K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000692 350.0
TLS2_k127_2340008_6 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000004122 243.0
TLS2_k127_2340008_7 Belongs to the LDH2 MDH2 oxidoreductase family K13574 - - 0.0000000000000000000000000000000000000000000000000000000001451 216.0
TLS2_k127_2340008_8 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000456 184.0
TLS2_k127_2340008_9 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.000000000000000000000000000000000000000001128 168.0
TLS2_k127_2375078_0 Sulfate permease family K03321 - - 2.433e-244 766.0
TLS2_k127_2375078_1 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 3.748e-214 684.0
TLS2_k127_2375078_10 Putative TM nitroreductase - - - 0.00000000000000000001096 101.0
TLS2_k127_2375078_11 Creatinase/Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.000000000000000006134 96.0
TLS2_k127_2375078_12 cytochrome - - - 0.0005298 45.0
TLS2_k127_2375078_2 N-methylhydantoinase B acetone carboxylase alpha subunit K01474 - 3.5.2.14 4.585e-195 622.0
TLS2_k127_2375078_3 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003808 283.0
TLS2_k127_2375078_4 Transposase IS200 like - - - 0.000000000000000000000000000000000000000000000000000000001034 206.0
TLS2_k127_2375078_5 proline dipeptidase activity K08688 - 3.5.3.3 0.0000000000000000000000000000000000000000000000000007518 197.0
TLS2_k127_2375078_6 DNA-binding transcription factor activity K03892 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000015 169.0
TLS2_k127_2375078_7 Ketopantoate reductase PanE/ApbA K00077 - 1.1.1.169 0.000000000000000000000000000000000000000003138 167.0
TLS2_k127_2375078_8 NMT1-like family K02051 - - 0.00000000000000000000000000000003228 138.0
TLS2_k127_2375078_9 PFAM Nitroreductase - - - 0.000000000000000000007862 102.0
TLS2_k127_2380671_0 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 515.0
TLS2_k127_2380671_1 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 449.0
TLS2_k127_2380671_10 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000008291 219.0
TLS2_k127_2380671_11 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000001597 216.0
TLS2_k127_2380671_12 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000006162 204.0
TLS2_k127_2380671_13 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000001883 186.0
TLS2_k127_2380671_14 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000000001731 175.0
TLS2_k127_2380671_15 Protein of unknown function (DUF423) - - - 0.00000000000000000000000000000000000000000007324 162.0
TLS2_k127_2380671_16 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000239 161.0
TLS2_k127_2380671_17 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.000000000000000000000000000000000009233 146.0
TLS2_k127_2380671_18 Predicted permease K07089 - - 0.000000000000000000000000000000001445 135.0
TLS2_k127_2380671_19 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000001229 117.0
TLS2_k127_2380671_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007123 389.0
TLS2_k127_2380671_20 oxidation-reduction process - - - 0.00000000000000000001208 96.0
TLS2_k127_2380671_21 Peptidase family M20/M25/M40 K01438 - 3.5.1.16 0.00000000000000000009511 103.0
TLS2_k127_2380671_23 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000001368 86.0
TLS2_k127_2380671_24 - - - - 0.0000000000000007458 89.0
TLS2_k127_2380671_25 Binding-protein-dependent transport system inner membrane component K02050,K15552 - - 0.0000000003593 64.0
TLS2_k127_2380671_26 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0000002637 54.0
TLS2_k127_2380671_27 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000005288 60.0
TLS2_k127_2380671_28 maleate cis-trans isomerase K01799 - 5.2.1.1 0.00004143 54.0
TLS2_k127_2380671_29 cobalt transporter subunit CbtB - - - 0.0001414 46.0
TLS2_k127_2380671_3 Conserved carboxylase domain K01571 - 4.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 387.0
TLS2_k127_2380671_30 Mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.0003512 47.0
TLS2_k127_2380671_4 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 317.0
TLS2_k127_2380671_5 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 307.0
TLS2_k127_2380671_6 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005749 283.0
TLS2_k127_2380671_7 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001649 269.0
TLS2_k127_2380671_8 Ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000006671 233.0
TLS2_k127_2380671_9 Glycerophosphoryl diester phosphodiesterase family K01113,K01126 - 3.1.3.1,3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000009476 241.0
TLS2_k127_2388885_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 502.0
TLS2_k127_2388885_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 470.0
TLS2_k127_2388885_10 Protein of unknown function (DUF1152) - - - 0.000000000000000000000000000000000000000000000001961 184.0
TLS2_k127_2388885_11 response regulator, receiver K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000008111 166.0
TLS2_k127_2388885_12 iron ion homeostasis K02012 - - 0.000000000000000000000000000000000000000001068 171.0
TLS2_k127_2388885_13 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000004007 158.0
TLS2_k127_2388885_14 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000005355 142.0
TLS2_k127_2388885_15 Domain of unknown function (DUF1992) - - - 0.000000000000000000000000000014 122.0
TLS2_k127_2388885_16 Histidine kinase - - - 0.0000000000000000000000000000411 136.0
TLS2_k127_2388885_17 response regulator K02479 - - 0.0000000000000000000008861 101.0
TLS2_k127_2388885_2 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 427.0
TLS2_k127_2388885_3 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 383.0
TLS2_k127_2388885_4 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 396.0
TLS2_k127_2388885_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000179 281.0
TLS2_k127_2388885_6 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004874 256.0
TLS2_k127_2388885_7 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000001775 224.0
TLS2_k127_2388885_8 Putative diguanylate phosphodiesterase K03320 - - 0.000000000000000000000000000000000000000000000000000000002263 227.0
TLS2_k127_2388885_9 Sigma-70, region 4 type 2 - - - 0.000000000000000000000000000000000000000000000000001254 190.0
TLS2_k127_240008_0 Zinc-binding dehydrogenase K19745 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 398.0
TLS2_k127_240008_1 L-carnitine dehydratase bile acid-inducible protein F - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007011 367.0
TLS2_k127_240008_2 N-terminal half of MaoC dehydratase K09709,K18291 - 4.2.1.153,4.2.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000001521 251.0
TLS2_k127_240008_3 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000004515 162.0
TLS2_k127_240008_4 Serine aminopeptidase, S33 - - - 0.000000000000000000008264 103.0
TLS2_k127_2426053_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 1.109e-237 749.0
TLS2_k127_2426053_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 1.194e-195 621.0
TLS2_k127_2426053_10 PFAM Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009042 376.0
TLS2_k127_2426053_11 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 378.0
TLS2_k127_2426053_12 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006751 371.0
TLS2_k127_2426053_13 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008675 345.0
TLS2_k127_2426053_14 Polysaccharide biosynthesis protein K01784,K08679 - 5.1.3.2,5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006333 340.0
TLS2_k127_2426053_15 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 331.0
TLS2_k127_2426053_16 acetyl-coa acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 332.0
TLS2_k127_2426053_17 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005804 324.0
TLS2_k127_2426053_18 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 327.0
TLS2_k127_2426053_19 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 317.0
TLS2_k127_2426053_2 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 589.0
TLS2_k127_2426053_20 Protein of unknown function (DUF1009) K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006308 299.0
TLS2_k127_2426053_21 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 287.0
TLS2_k127_2426053_22 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001109 313.0
TLS2_k127_2426053_23 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000317 246.0
TLS2_k127_2426053_24 PFAM glycosyl transferase family 9 K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000001164 247.0
TLS2_k127_2426053_25 peptide deformylase activity K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000002604 230.0
TLS2_k127_2426053_26 SUF system FeS assembly protein K04488 - - 0.000000000000000000000000000000000000000000000000000001969 195.0
TLS2_k127_2426053_27 FeS assembly SUF system protein SufT - - - 0.0000000000000000000000000000000000000000000000000005742 189.0
TLS2_k127_2426053_28 lipopolysaccharide heptosyltransferase K02841,K02843 - - 0.0000000000000000000000000000000000000000000000001793 190.0
TLS2_k127_2426053_29 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000003937 170.0
TLS2_k127_2426053_3 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005173 579.0
TLS2_k127_2426053_30 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000004198 177.0
TLS2_k127_2426053_31 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000005962 171.0
TLS2_k127_2426053_32 Pfam:DUF59 K02612 - - 0.00000000000000000000000000000000000000002046 154.0
TLS2_k127_2426053_33 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.000000000000000000000000000000001819 138.0
TLS2_k127_2426053_34 ornithine cyclodeaminase K01750 - 4.3.1.12 0.000000000000000000000000000000002421 133.0
TLS2_k127_2426053_35 - - - - 0.00000000000000000000000000000001632 140.0
TLS2_k127_2426053_36 COG2346, Truncated hemoglobins K06886 - - 0.0000000000000000000000000000911 120.0
TLS2_k127_2426053_37 - - - - 0.000000000000000000000002444 112.0
TLS2_k127_2426053_38 Belongs to the UPF0434 family K09791 - - 0.00000000000000000000001402 100.0
TLS2_k127_2426053_39 cellular response to dsDNA K11211 - 2.7.1.166 0.00000000000000000000003883 109.0
TLS2_k127_2426053_4 COG3385 FOG Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008671 565.0
TLS2_k127_2426053_40 kinase activity - - - 0.000000000000000000009221 103.0
TLS2_k127_2426053_41 - - - - 0.000000000000000001296 96.0
TLS2_k127_2426053_42 2 iron, 2 sulfur cluster binding - - - 0.00000000000000008499 87.0
TLS2_k127_2426053_43 unfolded protein binding K06142 - - 0.000004031 55.0
TLS2_k127_2426053_44 NACHT domain - - - 0.000008728 60.0
TLS2_k127_2426053_5 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004528 544.0
TLS2_k127_2426053_6 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 535.0
TLS2_k127_2426053_7 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 490.0
TLS2_k127_2426053_8 ABC transporter K09013 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 394.0
TLS2_k127_2426053_9 Conserved carboxylase domain K01571 - 4.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 389.0
TLS2_k127_2479520_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.174e-228 727.0
TLS2_k127_2479520_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 430.0
TLS2_k127_2479520_2 PFAM Bacterial protein of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001321 269.0
TLS2_k127_2479520_3 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000001608 181.0
TLS2_k127_2479520_4 Major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000733 161.0
TLS2_k127_250175_0 Amidohydrolase K07045 - - 0.00000000000000000000000000005773 124.0
TLS2_k127_2507268_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 9.111e-268 833.0
TLS2_k127_2507268_1 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 - 3.4.21.83 6.133e-263 827.0
TLS2_k127_2507268_10 carboxypeptidase activity K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000000000000000000000001195 253.0
TLS2_k127_2507268_11 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000009935 222.0
TLS2_k127_2507268_12 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000000002686 193.0
TLS2_k127_2507268_13 ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000004137 200.0
TLS2_k127_2507268_14 Domain of unknown function (DUF4124) K08309 - - 0.0000000000000000000000000000000000000000000004493 175.0
TLS2_k127_2507268_15 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000002218 178.0
TLS2_k127_2507268_16 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000007658 166.0
TLS2_k127_2507268_17 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000002382 158.0
TLS2_k127_2507268_18 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.0000000000000000000000000000000000000001603 151.0
TLS2_k127_2507268_19 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity K00950,K13940 - 2.7.6.3,4.1.2.25 0.000000000000000000000000000000000000387 149.0
TLS2_k127_2507268_2 ATP ADP translocase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 539.0
TLS2_k127_2507268_20 ACT domain K03567 - - 0.0000000000000000000000000000000005222 137.0
TLS2_k127_2507268_21 NUDIX domain K03574 - 3.6.1.55 0.00000000000000000000000000008007 121.0
TLS2_k127_2507268_22 YacP-like NYN domain K06962 - - 0.00000000000000000000000011 113.0
TLS2_k127_2507268_23 Belongs to the UPF0109 family K06960 - - 0.00000000000000000000003707 100.0
TLS2_k127_2507268_24 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.000000000000000000003945 99.0
TLS2_k127_2507268_25 mitochondrial translation K02959 GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000001844 101.0
TLS2_k127_2507268_26 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000001542 104.0
TLS2_k127_2507268_27 Bacterial extracellular solute-binding protein - - - 0.000000000000000002834 97.0
TLS2_k127_2507268_28 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000003644 83.0
TLS2_k127_2507268_29 Protein of unknown function (DUF507) - - - 0.000000000009018 71.0
TLS2_k127_2507268_3 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 516.0
TLS2_k127_2507268_30 Polymer-forming cytoskeletal - - - 0.000000002196 67.0
TLS2_k127_2507268_31 - - - - 0.00000007341 54.0
TLS2_k127_2507268_32 monooxygenase activity K00688,K15760,K16157,K16242,K18223,K22353,K22357 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494 1.14.13.227,1.14.13.236,1.14.13.25,1.14.13.69,2.4.1.1 0.0000006716 54.0
TLS2_k127_2507268_33 - - - - 0.000001143 59.0
TLS2_k127_2507268_34 Protein of unknown function (DUF502) - - - 0.000008926 51.0
TLS2_k127_2507268_35 Protein of unknown function (DUF507) K09804 - - 0.0008324 47.0
TLS2_k127_2507268_4 MgsA AAA+ ATPase C terminal K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 505.0
TLS2_k127_2507268_5 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 487.0
TLS2_k127_2507268_6 Mur ligase, middle domain K02558 - 6.3.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 462.0
TLS2_k127_2507268_7 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004687 420.0
TLS2_k127_2507268_8 COG0656 Aldo keto reductases, related to diketogulonate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004427 387.0
TLS2_k127_2507268_9 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004395 321.0
TLS2_k127_262464_0 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002031 243.0
TLS2_k127_262464_1 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.0000000000000000000000000000000000000001153 155.0
TLS2_k127_262464_2 Cold shock protein K03704 - - 0.0000000000000000000000000004019 117.0
TLS2_k127_267042_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 9.717e-246 771.0
TLS2_k127_267042_1 PFAM ABC transporter related K06147 - - 2.071e-212 676.0
TLS2_k127_267042_10 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 366.0
TLS2_k127_267042_11 Acetolactate synthase K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 337.0
TLS2_k127_267042_12 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 317.0
TLS2_k127_267042_13 PFAM Alcohol dehydrogenase, zinc-binding K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 314.0
TLS2_k127_267042_14 Aldo/keto reductase family K00002 - 1.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 298.0
TLS2_k127_267042_15 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005417 280.0
TLS2_k127_267042_16 TIM-barrel fold metal-dependent hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005126 271.0
TLS2_k127_267042_17 PFAM Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009466 263.0
TLS2_k127_267042_18 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000017 219.0
TLS2_k127_267042_19 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000538 206.0
TLS2_k127_267042_2 protein synonym multiple resistance and pH homeostasis protein A K05565 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 578.0
TLS2_k127_267042_20 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000005715 201.0
TLS2_k127_267042_21 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000006665 195.0
TLS2_k127_267042_22 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.000000000000000000000000000000000000000000003449 179.0
TLS2_k127_267042_23 Nodulation protein S (NodS) - - - 0.0000000000000000000000000000000000000000006072 169.0
TLS2_k127_267042_24 Protein of unknown function, DUF - - - 0.000000000000000000000000000000000002141 140.0
TLS2_k127_267042_25 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000009293 141.0
TLS2_k127_267042_26 PFAM GYD family protein - - - 0.000000000000000000000000000008646 123.0
TLS2_k127_267042_27 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.00000000000000000000000000001919 121.0
TLS2_k127_267042_28 Dehydrogenase - - - 0.00000000000000000000006116 112.0
TLS2_k127_267042_29 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000006568 109.0
TLS2_k127_267042_3 succinate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 496.0
TLS2_k127_267042_30 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000006659 92.0
TLS2_k127_267042_31 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 0.00000000000000127 80.0
TLS2_k127_267042_32 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000007016 79.0
TLS2_k127_267042_33 Cyclic nucleotide-monophosphate binding domain K10914 - - 0.000000000003325 68.0
TLS2_k127_267042_35 ABC transporter substrate-binding protein K02051 - - 0.00000000006047 74.0
TLS2_k127_267042_36 - - - - 0.0000000324 57.0
TLS2_k127_267042_37 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 GO:0005575,GO:0005576 1.3.3.11 0.000001295 59.0
TLS2_k127_267042_38 4-carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.000001661 55.0
TLS2_k127_267042_39 acyl carrier protein - - - 0.000002417 53.0
TLS2_k127_267042_4 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 464.0
TLS2_k127_267042_40 Lipid A biosynthesis K02517 - 2.3.1.241 0.0005476 51.0
TLS2_k127_267042_41 conserved protein, contains double-stranded beta-helix domain - - - 0.0005852 48.0
TLS2_k127_267042_5 acyl-CoA dehydrogenase activity K00252 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.3.8.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 458.0
TLS2_k127_267042_6 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K00087 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 441.0
TLS2_k127_267042_7 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 413.0
TLS2_k127_267042_8 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 375.0
TLS2_k127_267042_9 TIGRFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 379.0
TLS2_k127_2720386_0 Alpha beta hydrolase - - - 0.0000000000000000000000002785 116.0
TLS2_k127_2720386_1 PFAM alpha beta hydrolase fold - - - 0.0000000000001232 74.0
TLS2_k127_2720386_2 ABC transporter substrate-binding protein K02051 - - 0.0000000346 65.0
TLS2_k127_2746390_0 PFAM Hydantoinase oxoprolinase K01473,K10855 - 3.5.2.14,6.4.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008349 503.0
TLS2_k127_2746390_1 Trypsin-like peptidase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006093 349.0
TLS2_k127_2746390_10 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000002858 189.0
TLS2_k127_2746390_11 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000004274 186.0
TLS2_k127_2746390_12 - - - - 0.000000000000000000000000000000000000004816 153.0
TLS2_k127_2746390_13 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000003087 141.0
TLS2_k127_2746390_14 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000006554 129.0
TLS2_k127_2746390_15 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000000000169 136.0
TLS2_k127_2746390_16 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000637 120.0
TLS2_k127_2746390_17 - - - - 0.0000000000000000000000001919 111.0
TLS2_k127_2746390_19 NMT1-like family K02051 - - 0.00000000000003435 83.0
TLS2_k127_2746390_2 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008059 327.0
TLS2_k127_2746390_20 hydroperoxide reductase activity K01607 - 4.1.1.44 0.0000000000002075 74.0
TLS2_k127_2746390_21 protein conserved in bacteria - - - 0.00000000239 62.0
TLS2_k127_2746390_22 PA26 p53-induced protein (sestrin) - - - 0.0000026 52.0
TLS2_k127_2746390_23 ABC transporter, phosphonate, periplasmic substrate-binding protein K02051 - - 0.000003652 59.0
TLS2_k127_2746390_3 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 340.0
TLS2_k127_2746390_4 Dioxygenase K00449 - 1.13.11.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003146 282.0
TLS2_k127_2746390_5 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009839 292.0
TLS2_k127_2746390_6 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008469 283.0
TLS2_k127_2746390_7 proline dipeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000005943 229.0
TLS2_k127_2746390_8 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000002572 218.0
TLS2_k127_2746390_9 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000001495 199.0
TLS2_k127_27659_0 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 520.0
TLS2_k127_27659_1 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 529.0
TLS2_k127_27659_10 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533,K15396 - 2.1.1.200 0.00000000000000000000000000000000000000000000001797 180.0
TLS2_k127_27659_11 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000001852 177.0
TLS2_k127_27659_12 RHS Repeat - - - 0.000000000000000000000000000000000000000003411 165.0
TLS2_k127_27659_13 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000001945 166.0
TLS2_k127_27659_14 Histone methylation protein DOT1 - - - 0.000000000000000000000000000000000000000486 160.0
TLS2_k127_27659_15 protein conserved in bacteria K09778 - - 0.0000000000000000000000000000000011 138.0
TLS2_k127_27659_16 COG3639 ABC-type phosphate phosphonate transport system, permease component - - - 0.000000000000000000000000003787 112.0
TLS2_k127_27659_17 peptidyl-tyrosine sulfation - - - 0.0003691 48.0
TLS2_k127_27659_2 transcription factor binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009543 490.0
TLS2_k127_27659_3 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05541 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 389.0
TLS2_k127_27659_4 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002875 381.0
TLS2_k127_27659_5 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000009222 235.0
TLS2_k127_27659_6 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000005016 238.0
TLS2_k127_27659_7 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000001916 209.0
TLS2_k127_27659_8 Haloacid dehalogenase-like hydrolase - GO:0003674,GO:0003824,GO:0003850,GO:0004346,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0044237,GO:0050308,GO:0050309 - 0.0000000000000000000000000000000000000000000000000000003788 203.0
TLS2_k127_27659_9 Secreted and surface protein containing fasciclin-like repeats - - - 0.000000000000000000000000000000000000000000000000000003864 197.0
TLS2_k127_2809999_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005809 370.0
TLS2_k127_2809999_1 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 361.0
TLS2_k127_2809999_2 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 335.0
TLS2_k127_2809999_3 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 338.0
TLS2_k127_2809999_4 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003979 280.0
TLS2_k127_2809999_5 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000001629 153.0
TLS2_k127_2809999_6 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000003079 151.0
TLS2_k127_2809999_7 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.000000000000004064 87.0
TLS2_k127_2809999_8 Cupin 2, conserved barrel domain protein - - - 0.00000000000006612 76.0
TLS2_k127_2827174_0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 401.0
TLS2_k127_2827174_1 Domain of unknown function (DUF4070) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006608 404.0
TLS2_k127_2827174_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002949 345.0
TLS2_k127_2827174_3 PFAM Pentapeptide repeats (8 copies) - - - 0.000006359 57.0
TLS2_k127_283006_0 von Willebrand factor (vWF) type A domain K02448 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007948 314.0
TLS2_k127_283006_1 Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000625 189.0
TLS2_k127_283006_2 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000001417 194.0
TLS2_k127_283957_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0 1111.0
TLS2_k127_283957_1 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 1.147e-260 816.0
TLS2_k127_283957_10 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004424 464.0
TLS2_k127_283957_11 FMN-dependent dehydrogenase K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 351.0
TLS2_k127_283957_12 formate dehydrogenase (NAD+) activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 323.0
TLS2_k127_283957_13 Nitrogen fixation master sensor histidine kinase, PAS domain-containing K02668,K07708,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 316.0
TLS2_k127_283957_14 PFAM Nitrile hydratase alpha K01721 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001292 274.0
TLS2_k127_283957_15 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000001328 220.0
TLS2_k127_283957_16 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000000000514 202.0
TLS2_k127_283957_17 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000003422 187.0
TLS2_k127_283957_18 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788,K14153 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000008692 183.0
TLS2_k127_283957_19 transferase activity, transferring acyl groups - - - 0.000000000000000000000000000000000000000000108 168.0
TLS2_k127_283957_2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.424e-256 819.0
TLS2_k127_283957_20 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000001764 154.0
TLS2_k127_283957_21 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000000000003327 140.0
TLS2_k127_283957_22 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000285 138.0
TLS2_k127_283957_23 KR domain - - - 0.0000000000000000000000000000002362 126.0
TLS2_k127_283957_24 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000007302 116.0
TLS2_k127_283957_25 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.000000000000000000000007623 108.0
TLS2_k127_283957_26 Domain of unknown function DUF123 - - - 0.00000000000000000000003534 103.0
TLS2_k127_283957_27 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000002862 97.0
TLS2_k127_283957_28 Protein of unknown function (DUF503) K09764 - - 0.00000000000000000006566 92.0
TLS2_k127_283957_29 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.00000000000002433 76.0
TLS2_k127_283957_3 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 9.828e-250 781.0
TLS2_k127_283957_30 - - - - 0.0000000001611 69.0
TLS2_k127_283957_31 Protein of unknown function (DUF448) K07742 - - 0.0000003589 57.0
TLS2_k127_283957_4 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 2.296e-196 629.0
TLS2_k127_283957_5 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 554.0
TLS2_k127_283957_6 PFAM monooxygenase FAD-binding K00481 - 1.14.13.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006825 538.0
TLS2_k127_283957_7 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009242 514.0
TLS2_k127_283957_8 Bacterial regulatory protein, Fis family K07712 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006795 503.0
TLS2_k127_283957_9 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00122,K00335 - 1.17.1.9,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 481.0
TLS2_k127_2896259_0 TIGRFAM phosphoenolpyruvate-protein phosphotransferase K08484 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009134 605.0
TLS2_k127_2896259_1 Alcohol dehydrogenase GroES-like domain K13979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007642 554.0
TLS2_k127_2896259_10 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 372.0
TLS2_k127_2896259_11 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K15585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000685 344.0
TLS2_k127_2896259_12 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 354.0
TLS2_k127_2896259_13 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000212 283.0
TLS2_k127_2896259_14 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005193 286.0
TLS2_k127_2896259_15 N-4 methylation of cytosine K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001815 280.0
TLS2_k127_2896259_16 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001065 262.0
TLS2_k127_2896259_17 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000379 240.0
TLS2_k127_2896259_18 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.000000000000000000000000000000000000000000000000000000000000006741 230.0
TLS2_k127_2896259_19 Family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000000000002818 231.0
TLS2_k127_2896259_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 537.0
TLS2_k127_2896259_20 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000001875 219.0
TLS2_k127_2896259_21 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000001632 196.0
TLS2_k127_2896259_22 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000114 195.0
TLS2_k127_2896259_23 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000000000000000000000001936 193.0
TLS2_k127_2896259_24 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000001415 192.0
TLS2_k127_2896259_25 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000005825 174.0
TLS2_k127_2896259_26 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) - - - 0.0000000000000000000000000000000000000001589 164.0
TLS2_k127_2896259_27 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.00000000000000000000000000000000000004643 146.0
TLS2_k127_2896259_28 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000001912 126.0
TLS2_k127_2896259_29 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000003491 120.0
TLS2_k127_2896259_3 glycyl-radical enzyme activating activity K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006641 509.0
TLS2_k127_2896259_30 - - - - 0.000000000000000000000001101 108.0
TLS2_k127_2896259_31 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000534 113.0
TLS2_k127_2896259_32 NMT1-like family - - - 0.0000000000000000193 93.0
TLS2_k127_2896259_33 N-4 methylation of cytosine K00571 - 2.1.1.72 0.00000000000000005728 85.0
TLS2_k127_2896259_34 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00335,K18331,K22339 - 1.12.1.3,1.17.1.11,1.6.5.3 0.0000000000000159 77.0
TLS2_k127_2896259_4 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 499.0
TLS2_k127_2896259_5 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 423.0
TLS2_k127_2896259_6 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007292 374.0
TLS2_k127_2896259_7 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 384.0
TLS2_k127_2896259_8 PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 376.0
TLS2_k127_2896259_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 374.0
TLS2_k127_2896332_0 PBP superfamily domain K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 308.0
TLS2_k127_2896332_1 COG0620 Methionine synthase II (cobalamin-independent) K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000001006 246.0
TLS2_k127_2896332_2 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000001021 210.0
TLS2_k127_2896332_3 NMT1-like family - - - 0.0000000000000000000000000000000000000000314 166.0
TLS2_k127_2896332_4 Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c - GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.000000000000000633 81.0
TLS2_k127_2896332_5 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000003423 73.0
TLS2_k127_2905703_0 5-oxoprolinase K01473 - 3.5.2.14 7.512e-215 686.0
TLS2_k127_2905703_1 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain K03520,K11177 - 1.17.1.4,1.2.5.3 1.657e-205 662.0
TLS2_k127_2905703_10 NMT1-like family K02051 - - 0.000000009202 68.0
TLS2_k127_2905703_11 NMT1-like family K02051 - - 0.00000005085 64.0
TLS2_k127_2905703_2 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 554.0
TLS2_k127_2905703_3 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006179 536.0
TLS2_k127_2905703_4 PFAM Amidohydrolase 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 380.0
TLS2_k127_2905703_5 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001404 276.0
TLS2_k127_2905703_6 Cupin 2, conserved barrel domain protein K00450,K11948 - 1.13.11.38,1.13.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001614 283.0
TLS2_k127_2905703_7 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004419 260.0
TLS2_k127_2905703_8 PFAM S23 ribosomal protein - - - 0.0000000000000000000000000000000000002067 144.0
TLS2_k127_2905703_9 Substrate binding domain of ABC-type glycine betaine transport system K02051 - - 0.00000000000000003479 93.0
TLS2_k127_2927965_0 PFAM Na Pi-cotransporter K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008082 493.0
TLS2_k127_2927965_1 nuclear-transcribed mRNA catabolic process, no-go decay - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009412 369.0
TLS2_k127_293817_0 Isochorismatase hydrolase - - - 0.00000000000000000000000000000000000000000000000000000002047 205.0
TLS2_k127_293817_1 Creatinase/Prolidase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000002204 197.0
TLS2_k127_293817_2 Ornithine cyclodeaminase K01750 - 4.3.1.12 0.0000000000000000000000000000000000000000007724 164.0
TLS2_k127_293817_3 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000004419 66.0
TLS2_k127_2940657_0 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000357 200.0
TLS2_k127_2940657_1 metal-dependent hydrolase of the TIM-barrel fold - - - 0.000000000000000000000000000000000000000000000000008869 189.0
TLS2_k127_2940657_2 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000689 120.0
TLS2_k127_2940657_3 Tripartite tricarboxylate transporter family receptor - - - 0.000000000002051 77.0
TLS2_k127_2940657_4 Tripartite tricarboxylate transporter family receptor - - - 0.0000000592 63.0
TLS2_k127_2959321_0 TIR domain - - - 0.0000000000000000000000000000001556 141.0
TLS2_k127_2959321_1 Tripartite tricarboxylate transporter family receptor - - - 0.000001116 53.0
TLS2_k127_2964093_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.346e-237 758.0
TLS2_k127_2964093_1 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002806 302.0
TLS2_k127_2964093_2 COG2513 PEP phosphonomutase and related enzymes - - - 0.000000000000000000000000000000000000000000000000008179 191.0
TLS2_k127_2964093_3 protein conserved in bacteria - - - 0.00000000000000000000000000000000000001469 154.0
TLS2_k127_2964093_4 positive regulation of type IV pilus biogenesis K07343 - - 0.000000000000000000000000000000002421 133.0
TLS2_k127_2964093_5 Protein of unknown function (DUF983) - - - 0.0000000000000000000000009309 108.0
TLS2_k127_2964093_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000004999 108.0
TLS2_k127_2964093_7 cobalamin (vitamin B12) biosynthesis CbiX protein - - - 0.00000000001785 68.0
TLS2_k127_2981117_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798,K04076,K13525,K17681 - 3.4.21.53 8.93e-228 713.0
TLS2_k127_2981117_1 Cytokinin riboside 5'-monophosphate phosphoribohydrolase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 293.0
TLS2_k127_2981117_2 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000002502 112.0
TLS2_k127_300382_0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007962 558.0
TLS2_k127_300382_1 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000006725 127.0
TLS2_k127_300382_2 PFAM Na Pi-cotransporter K03324 - - 0.000000000000000000003708 96.0
TLS2_k127_3008631_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.0 1218.0
TLS2_k127_3008631_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 2.307e-215 681.0
TLS2_k127_3008631_10 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000193 190.0
TLS2_k127_3008631_11 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000004232 189.0
TLS2_k127_3008631_12 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000001377 144.0
TLS2_k127_3008631_13 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.0000000000000000000000000000000002862 139.0
TLS2_k127_3008631_14 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.000000000000000000000000000000018 129.0
TLS2_k127_3008631_15 AMP binding - - - 0.00000000000000000000000000000177 130.0
TLS2_k127_3008631_16 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000001744 118.0
TLS2_k127_3008631_17 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000002319 97.0
TLS2_k127_3008631_18 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000005142 96.0
TLS2_k127_3008631_19 Ribosomal protein L35 K02916 - - 0.0000000000000000001282 90.0
TLS2_k127_3008631_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 3.146e-197 633.0
TLS2_k127_3008631_20 NUDIX domain K03574 - 3.6.1.55 0.000000000000000001848 91.0
TLS2_k127_3008631_21 Prokaryotic dksA traR C4-type zinc finger - - - 0.000000008375 62.0
TLS2_k127_3008631_22 Putative regulatory protein - - - 0.00000001642 58.0
TLS2_k127_3008631_23 mannose-1-phosphate guanylyltransferase activity K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000003463 54.0
TLS2_k127_3008631_24 Belongs to the 'phage' integrase family - - - 0.0008962 48.0
TLS2_k127_3008631_3 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 4.241e-194 616.0
TLS2_k127_3008631_4 PFAM magnesium chelatase ChlI subunit K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005042 566.0
TLS2_k127_3008631_5 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 500.0
TLS2_k127_3008631_6 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003012 434.0
TLS2_k127_3008631_7 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007067 399.0
TLS2_k127_3008631_8 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000007211 243.0
TLS2_k127_3008631_9 PFAM Cold-shock protein, DNA-binding - - - 0.0000000000000000000000000000000000000000000000000000000000009605 221.0
TLS2_k127_3010614_0 UPF0761 membrane protein K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 478.0
TLS2_k127_3010614_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 463.0
TLS2_k127_3010614_10 Histidine kinase K07716,K20974 - 2.7.13.3 0.0000000000000000000000000000000000000000103 172.0
TLS2_k127_3010614_11 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000002223 166.0
TLS2_k127_3010614_12 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.0000000000000000000000000000000000000334 155.0
TLS2_k127_3010614_13 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000371 121.0
TLS2_k127_3010614_14 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000004153 102.0
TLS2_k127_3010614_15 NMT1-like family K02051 - - 0.000000000000000000973 98.0
TLS2_k127_3010614_16 Antibiotic biosynthesis monooxygenase K11530 - 5.3.1.32 0.00000000000000003534 87.0
TLS2_k127_3010614_17 Acetyltransferase (GNAT) family K18816 - 2.3.1.82 0.00000002085 59.0
TLS2_k127_3010614_18 nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.0000004291 56.0
TLS2_k127_3010614_19 NfeD-like C-terminal, partner-binding K07403 - - 0.000004427 54.0
TLS2_k127_3010614_2 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 452.0
TLS2_k127_3010614_20 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00001116 57.0
TLS2_k127_3010614_21 Protein of unknown function, DUF488 - - - 0.0001307 48.0
TLS2_k127_3010614_22 4Fe-4S dicluster domain K17723 - 1.3.1.1 0.0004444 48.0
TLS2_k127_3010614_3 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 410.0
TLS2_k127_3010614_4 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006551 410.0
TLS2_k127_3010614_5 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006785 369.0
TLS2_k127_3010614_6 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 366.0
TLS2_k127_3010614_7 SMART ATP-binding region ATPase domain protein K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002005 277.0
TLS2_k127_3010614_8 protein related to plant photosystem II stability assembly factor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001157 273.0
TLS2_k127_3010614_9 Rieske [2Fe-2S] domain K15060 - - 0.00000000000000000000000000000000000000000000000000000000001471 223.0
TLS2_k127_3027614_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 2.087e-273 859.0
TLS2_k127_3027614_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 3.908e-216 685.0
TLS2_k127_3027614_10 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 299.0
TLS2_k127_3027614_11 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002429 297.0
TLS2_k127_3027614_12 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001271 262.0
TLS2_k127_3027614_13 ADP-L-glycero-beta-D-manno-heptose biosynthetic process K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000193 267.0
TLS2_k127_3027614_14 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001617 258.0
TLS2_k127_3027614_15 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000004467 244.0
TLS2_k127_3027614_16 O-methyltransferase K00588 - 2.1.1.104 0.00000000000000000000000000000000000000000000000000000000000000007425 228.0
TLS2_k127_3027614_17 Cytidylate kinase K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000002874 218.0
TLS2_k127_3027614_18 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000003279 209.0
TLS2_k127_3027614_19 Enoyl-(Acyl carrier protein) reductase K00059,K18009,K19548 - 1.1.1.100,1.1.1.304,1.1.1.385,1.1.1.76 0.000000000000000000000000000000000000000000000000000000003804 208.0
TLS2_k127_3027614_2 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03404,K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 564.0
TLS2_k127_3027614_20 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000001947 202.0
TLS2_k127_3027614_21 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.000000000000000000000000000000000000000000000000006035 192.0
TLS2_k127_3027614_22 Bis-adenosyl-polyphosphate hydrolase, FHIT domain-containing K19710 - 2.7.7.53 0.00000000000000000000000000000000000000000000000004168 182.0
TLS2_k127_3027614_23 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000007265 170.0
TLS2_k127_3027614_24 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000171 170.0
TLS2_k127_3027614_25 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000001736 165.0
TLS2_k127_3027614_26 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000002297 164.0
TLS2_k127_3027614_27 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000008923 132.0
TLS2_k127_3027614_28 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.00000000000000000000000000158 114.0
TLS2_k127_3027614_29 Glycosyl transferase family group 2 - - - 0.00000000000000000000000002005 120.0
TLS2_k127_3027614_3 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 520.0
TLS2_k127_3027614_30 Glycosyl transferase family group 2 - - - 0.00000000000000000000002374 111.0
TLS2_k127_3027614_31 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000001131 83.0
TLS2_k127_3027614_32 Glycosyltransferase like family 2 K20444 - - 0.000000000002921 77.0
TLS2_k127_3027614_4 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 445.0
TLS2_k127_3027614_5 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 408.0
TLS2_k127_3027614_6 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008278 423.0
TLS2_k127_3027614_7 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008532 393.0
TLS2_k127_3027614_8 cobalamin synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004454 340.0
TLS2_k127_3027614_9 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008586 337.0
TLS2_k127_3077587_0 Carboxyl transferase domain K01966,K17489 - 2.1.3.1,2.1.3.15,6.4.1.3 4.107e-239 749.0
TLS2_k127_3077587_1 Biotin carboxylase K01961,K01965 - 6.3.4.14,6.4.1.2,6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 568.0
TLS2_k127_3077587_10 PFAM Electron transfer flavoprotein alpha beta-subunit K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000006735 237.0
TLS2_k127_3077587_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.000000000000000000000000000000000000000000000000008258 193.0
TLS2_k127_3077587_12 protein conserved in bacteria - - - 0.00000000000000000000000000000000000004892 154.0
TLS2_k127_3077587_13 Phenylacetic acid - - - 0.000000000000000000000000000000000000697 148.0
TLS2_k127_3077587_14 Biotin-requiring enzyme - - - 0.0000000000000000000000000000000004061 138.0
TLS2_k127_3077587_15 DoxX K15977 - - 0.0000000000000001035 85.0
TLS2_k127_3077587_16 mttA/Hcf106 family K03116,K03117 - - 0.0000000000000001051 82.0
TLS2_k127_3077587_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 554.0
TLS2_k127_3077587_3 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 478.0
TLS2_k127_3077587_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008301 377.0
TLS2_k127_3077587_5 Metallopeptidase family M24 K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 377.0
TLS2_k127_3077587_6 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 316.0
TLS2_k127_3077587_7 electron transfer flavoprotein, alpha subunit K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 296.0
TLS2_k127_3077587_8 Belongs to the PdaD family K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008585 266.0
TLS2_k127_3077587_9 Ornithine cyclodeaminase/mu-crystallin family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000141 273.0
TLS2_k127_3097417_0 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 429.0
TLS2_k127_3097417_1 TIGRFAM phosphate binding protein K02040 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003924 305.0
TLS2_k127_3097417_2 PFAM Binding-protein-dependent transport system inner membrane component K02038 - - 0.00000000000000000000000000000000000000000008081 163.0
TLS2_k127_3128600_0 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000003463 192.0
TLS2_k127_3128600_1 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000005234 185.0
TLS2_k127_3128600_2 Protein of unknown function (DUF2914) - - - 0.0000000000000000000000000000002229 137.0
TLS2_k127_3128600_3 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000001581 88.0
TLS2_k127_3128600_4 NMT1-like family K02051,K15553 - - 0.0000000000002258 81.0
TLS2_k127_3128600_5 Tripartite tricarboxylate transporter TctA K07793 - - 0.00000000263 64.0
TLS2_k127_3128600_6 NMT1-like family K02051 - - 0.00000002965 65.0
TLS2_k127_3128600_7 heme oxygenase (decyclizing) activity K21481 - 1.14.99.57 0.0002551 49.0
TLS2_k127_3200906_0 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 488.0
TLS2_k127_3200906_1 geranylgeranyl reductase activity K21401 - 1.3.99.38 0.000000000000000000000000000000000000000000006442 177.0
TLS2_k127_3200906_2 Methyltransferase - - - 0.000000000000000000000000000000000158 138.0
TLS2_k127_327140_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 540.0
TLS2_k127_327140_1 Protein of unknown function, DUF547 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 306.0
TLS2_k127_327140_2 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000001223 221.0
TLS2_k127_327140_3 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000000000000000000000002539 141.0
TLS2_k127_3298880_0 Tripartite tricarboxylate transporter TctA family - - - 1.37e-246 778.0
TLS2_k127_3298880_1 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 446.0
TLS2_k127_3298880_10 Selenoprotein B glycine betaine sarcosine D-proline reductase K10794 - 1.21.4.1 0.000000006864 63.0
TLS2_k127_3298880_2 Belongs to the TPP enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007605 384.0
TLS2_k127_3298880_3 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003744 340.0
TLS2_k127_3298880_4 TIM-barrel fold metal-dependent hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 336.0
TLS2_k127_3298880_5 MmgE/PrpD family K01720 - 4.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 330.0
TLS2_k127_3298880_6 tungstate binding K02020 - - 0.0000000000000000000000000000000000000000000004623 176.0
TLS2_k127_3298880_7 Protein of unknown function (DUF664) - - - 0.00000000000000000000000000000000003095 141.0
TLS2_k127_3298880_9 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00000000001328 76.0
TLS2_k127_3301301_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 520.0
TLS2_k127_3301301_1 Belongs to the GST superfamily K11209 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000398 288.0
TLS2_k127_3301301_2 Major Facilitator Superfamily - - - 0.000000000001483 71.0
TLS2_k127_3323053_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 474.0
TLS2_k127_3323053_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008107 412.0
TLS2_k127_3323053_2 nitrogen compound transport K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 339.0
TLS2_k127_3323053_3 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000081 240.0
TLS2_k127_3325544_0 Belongs to the glycosyl hydrolase 57 family - - - 2.448e-296 930.0
TLS2_k127_3325544_1 PFAM glycoside hydrolase family 77 K00705 - 2.4.1.25 1.135e-203 655.0
TLS2_k127_3325544_10 Belongs to the Pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005556 343.0
TLS2_k127_3325544_11 PFAM ABC transporter K02010,K02017,K02062,K10112,K10199,K17314 - 3.6.3.29,3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006384 316.0
TLS2_k127_3325544_12 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008559 287.0
TLS2_k127_3325544_13 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000276 276.0
TLS2_k127_3325544_14 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000004966 232.0
TLS2_k127_3325544_15 ABC transporter, permease protein K02011 - - 0.0000000000000000000000000000000000000000000000000000000007267 223.0
TLS2_k127_3325544_16 4,5-dihydroxyphthalate decarboxylase - - - 0.000000000000000000000000000000000000000000000000004584 193.0
TLS2_k127_3325544_17 TIM-barrel fold metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000000000000004224 190.0
TLS2_k127_3325544_18 Cupin domain K00450 - 1.13.11.4 0.0000000000000000000000000000000000000000000000007932 188.0
TLS2_k127_3325544_19 PFAM Phage derived protein Gp49-like (DUF891) - GO:0001666,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0036293,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0045926,GO:0045927,GO:0046483,GO:0048518,GO:0048519,GO:0050789,GO:0050896,GO:0065007,GO:0070482,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 - 0.0000000000000000000000000000000000000000000002079 169.0
TLS2_k127_3325544_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 592.0
TLS2_k127_3325544_20 Cupin domain - - - 0.0000000000000000000000000000000000000000000003581 171.0
TLS2_k127_3325544_21 OmpA family - - - 0.00000000000000000000000000000000000001154 152.0
TLS2_k127_3325544_22 FecR protein - - - 0.0000000000000000000000000000000000001933 147.0
TLS2_k127_3325544_23 sequence-specific DNA binding - - - 0.0000000000000000000000000000000000002097 147.0
TLS2_k127_3325544_24 - - - - 0.0000000000000000000000000000004298 128.0
TLS2_k127_3325544_25 STAS domain K06378 - - 0.000000000000000000000005006 105.0
TLS2_k127_3325544_26 Cupin domain - - - 0.0000000000000000000001255 103.0
TLS2_k127_3325544_27 anti-sigma regulatory factor, serine threonine protein kinase - - - 0.00000000000000000000549 98.0
TLS2_k127_3325544_28 COG0589 Universal stress protein UspA and related nucleotide-binding - - - 0.0000000000000000005079 93.0
TLS2_k127_3325544_29 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000005017 96.0
TLS2_k127_3325544_3 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 553.0
TLS2_k127_3325544_30 Biotin-lipoyl like K02005 - - 0.000000001638 65.0
TLS2_k127_3325544_31 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.000001289 52.0
TLS2_k127_3325544_4 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 486.0
TLS2_k127_3325544_5 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 471.0
TLS2_k127_3325544_6 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042,K17468 - 2.9.1.1,4.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007309 450.0
TLS2_k127_3325544_7 CHASE2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 450.0
TLS2_k127_3325544_8 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004995 350.0
TLS2_k127_3325544_9 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003869 338.0
TLS2_k127_3326680_0 Phospholipase D Transphosphatidylase K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 350.0
TLS2_k127_3326680_1 Phospholipase D. Active site motifs. - - - 0.000000000000000000000000000000000000000001295 165.0
TLS2_k127_3326680_2 HNH endonuclease K07454 - - 0.00000000000000002492 87.0
TLS2_k127_3326680_3 HNH endonuclease K07454 - - 0.0000000000204 67.0
TLS2_k127_3326680_4 - - - - 0.00004061 51.0
TLS2_k127_3336038_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008344 425.0
TLS2_k127_3336038_1 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.00000000000000000002733 100.0
TLS2_k127_3337417_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 416.0
TLS2_k127_3337417_1 AAA domain K07133 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 301.0
TLS2_k127_3337417_2 transposase activity K07483,K07497 - - 0.000001395 51.0
TLS2_k127_3353384_0 Protein of unknown function (DUF3500) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006789 411.0
TLS2_k127_3353384_1 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003547 265.0
TLS2_k127_3353384_10 chromate transporter K07240 - - 0.0000000000003057 72.0
TLS2_k127_3353384_11 NMT1-like family K02051 - - 0.00000004015 64.0
TLS2_k127_3353384_2 23S rRNA (guanine(2445)-N(2))-methyltransferase activity K21515 - 2.1.1.209 0.0000000000000000000000000000000000000000000000000000000000003771 217.0
TLS2_k127_3353384_3 PFAM Cell wall hydrolase - - - 0.000000000000000000000000000000000000001564 154.0
TLS2_k127_3353384_4 membrane - - - 0.000000000000000000000000000753 114.0
TLS2_k127_3353384_5 Isochorismatase family - - - 0.000000000000000000000000004404 118.0
TLS2_k127_3353384_6 ribonuclease BN K07058 - - 0.00000000000000000000000001374 121.0
TLS2_k127_3353384_7 NMT1-like family K02051 - - 0.0000000000000000002673 99.0
TLS2_k127_3353384_8 PFAM NMT1 THI5 like domain protein K02051 - - 0.0000000000000001139 93.0
TLS2_k127_3353384_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.0000000000000005712 83.0
TLS2_k127_3355901_0 ABC transporter K03701 - - 4.061e-314 984.0
TLS2_k127_3355901_1 FeS assembly protein SufB K07033,K09014 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - 4.048e-276 857.0
TLS2_k127_3355901_10 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 304.0
TLS2_k127_3355901_11 CHASE3 domain K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 299.0
TLS2_k127_3355901_12 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006628 283.0
TLS2_k127_3355901_13 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000856 284.0
TLS2_k127_3355901_14 ABC transporter substrate binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000768 269.0
TLS2_k127_3355901_15 ABC transporter substrate binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001313 250.0
TLS2_k127_3355901_16 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000211 233.0
TLS2_k127_3355901_17 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000001608 229.0
TLS2_k127_3355901_18 Two component signalling adaptor domain K03408 - - 0.00000000000000000000000000000000000000000009742 164.0
TLS2_k127_3355901_19 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000003578 158.0
TLS2_k127_3355901_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003481 554.0
TLS2_k127_3355901_20 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000323 166.0
TLS2_k127_3355901_21 CheD chemotactic sensory transduction K03411 - 3.5.1.44 0.0000000000000000000000000000000000000002452 158.0
TLS2_k127_3355901_22 SurA N-terminal domain K03771 - 5.2.1.8 0.00000000000000000000000000000000000001418 161.0
TLS2_k127_3355901_23 Acetyltransferase (GNAT) domain K03824 - - 0.0000000000000000000000000000000000001164 147.0
TLS2_k127_3355901_24 Circadian clock protein KaiC K08482 - - 0.0000000000000000000000000000000000004005 149.0
TLS2_k127_3355901_25 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000007024 144.0
TLS2_k127_3355901_26 Belongs to the UPF0145 family - - - 0.000000000000000000000000000000001241 132.0
TLS2_k127_3355901_27 Lipid A biosynthesis K02517 - 2.3.1.241 0.000000000000000000000000000000005026 145.0
TLS2_k127_3355901_28 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000002044 130.0
TLS2_k127_3355901_29 Iron-sulphur cluster biosynthesis - - - 0.0000000000000000000000000000004016 131.0
TLS2_k127_3355901_3 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 541.0
TLS2_k127_3355901_30 GIY-YIG catalytic domain - - - 0.000000000000000000000000000004064 122.0
TLS2_k127_3355901_31 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K06034 - 4.1.1.79 0.00000000000000000000000000001791 124.0
TLS2_k127_3355901_32 Transcriptional regulator - - - 0.0000000000000000000000000003745 121.0
TLS2_k127_3355901_33 Thioredoxin-like - - - 0.000000000000000000000000002712 119.0
TLS2_k127_3355901_34 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.0000000000000000000000002369 114.0
TLS2_k127_3355901_35 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000004526 111.0
TLS2_k127_3355901_36 response regulator K03413 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000769 100.0
TLS2_k127_3355901_37 Chemotaxis phosphatase CheX - - - 0.000000000000000001165 97.0
TLS2_k127_3355901_38 - - - - 0.000000000000009395 75.0
TLS2_k127_3355901_39 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589,K13052 - - 0.0000000000003682 75.0
TLS2_k127_3355901_4 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 523.0
TLS2_k127_3355901_40 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000006496 64.0
TLS2_k127_3355901_41 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000001312 58.0
TLS2_k127_3355901_42 - - - - 0.0008381 44.0
TLS2_k127_3355901_5 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 501.0
TLS2_k127_3355901_6 Chemotaxis protein histidine kinase and related kinases K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 506.0
TLS2_k127_3355901_7 phosphoesterase, PA-phosphatase related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003399 405.0
TLS2_k127_3355901_8 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004113 396.0
TLS2_k127_3355901_9 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 308.0
TLS2_k127_3364450_0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007339 413.0
TLS2_k127_3364450_1 In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination K10670 - 1.21.4.2,1.21.4.3,1.21.4.4 0.0000000000000000000000000000004435 124.0
TLS2_k127_3364450_2 Psort location Cytoplasmic, score - - - 0.0000000000000001508 81.0
TLS2_k127_3364450_3 In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination K10670 - 1.21.4.2,1.21.4.3,1.21.4.4 0.0000000001119 62.0
TLS2_k127_3369143_0 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009366 312.0
TLS2_k127_3378224_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335,K18331 - 1.12.1.3,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008054 512.0
TLS2_k127_3378224_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006091 484.0
TLS2_k127_3378224_10 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000002513 133.0
TLS2_k127_3378224_11 Protein of unknown function (DUF664) - - - 0.0000000000000000000000000000019 127.0
TLS2_k127_3378224_12 sulfopyruvate decarboxylase, alpha subunit K06034 - 4.1.1.79 0.00000000000000000000000006955 113.0
TLS2_k127_3378224_13 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.0000007138 53.0
TLS2_k127_3378224_2 formate dehydrogenase (NAD+) activity K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005783 442.0
TLS2_k127_3378224_3 enzyme of poly-gamma-glutamate biosynthesis (Capsule formation) K07282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 358.0
TLS2_k127_3378224_4 quinone binding K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 330.0
TLS2_k127_3378224_5 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009139 312.0
TLS2_k127_3378224_6 Cobalamin biosynthesis protein cbiG - - - 0.0000000000000000000000000000000000000000000000002618 188.0
TLS2_k127_3378224_7 COG1905 NADH ubiquinone oxidoreductase 24 kD subunit K00334,K03943 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000002629 177.0
TLS2_k127_3378224_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000009578 162.0
TLS2_k127_3378224_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.3 0.0000000000000000000000000000000003881 134.0
TLS2_k127_3443263_0 cellulose binding - - - 4.415e-220 686.0
TLS2_k127_3443263_1 TRAP transporter, 4TM 12TM fusion protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005578 500.0
TLS2_k127_3443263_10 NADPH-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000000000000001103 214.0
TLS2_k127_3443263_11 PFAM glutathione-dependent formaldehyde-activating GFA - - - 0.0000000000000000000000000000000000000000000000000000000001381 204.0
TLS2_k127_3443263_12 Protein conserved in bacteria K04750 - - 0.000000000000000000000000000000000000000000000000000000009647 203.0
TLS2_k127_3443263_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000003469 206.0
TLS2_k127_3443263_14 Protein of unknown function (DUF1428) - - - 0.00000000000000000000000000000000000000000000000000000003683 198.0
TLS2_k127_3443263_15 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - 0.000000000000000000000000000000000000000006782 155.0
TLS2_k127_3443263_16 TRAP transporter solute receptor TAXI family protein K07080 - - 0.00000000000000000000000000000000000000000695 168.0
TLS2_k127_3443263_17 glyoxalase III activity K00970 - 2.7.7.19 0.000000000000000000000000000000000000003253 149.0
TLS2_k127_3443263_18 Amidohydrolase family - - - 0.00000000000000000000000000000000003125 153.0
TLS2_k127_3443263_19 COG0457 FOG TPR repeat - - - 0.00000000000000000000000002125 114.0
TLS2_k127_3443263_20 Sulfur oxidation protein SoxY K17226 - - 0.0000000000000000000003964 103.0
TLS2_k127_3443263_21 Sulphur oxidation protein SoxZ K17227 - - 0.0000000000003557 78.0
TLS2_k127_3443263_22 lipolytic protein G-D-S-L family - - - 0.000000171 63.0
TLS2_k127_3443263_23 PFAM cytochrome c - - - 0.0000003198 59.0
TLS2_k127_3443263_3 Sulfide dehydrogenase K05301,K17218 - 1.8.2.1,1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 371.0
TLS2_k127_3443263_4 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 317.0
TLS2_k127_3443263_5 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001684 263.0
TLS2_k127_3443263_6 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001495 238.0
TLS2_k127_3443263_7 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000005845 233.0
TLS2_k127_3443263_8 YCII-related domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001206 231.0
TLS2_k127_3443263_9 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000000000000000000000000000000000000000000000000000001628 231.0
TLS2_k127_3482464_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 1.077e-223 706.0
TLS2_k127_3482464_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 538.0
TLS2_k127_3482464_11 MarR family transcriptional regulator - - - 0.000000000000000000000000000000000000000000004854 169.0
TLS2_k127_3482464_12 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.0000000000000000000000000000000000000001801 152.0
TLS2_k127_3482464_13 NMT1-like family - - - 0.00000000000000000000000000000000000006031 157.0
TLS2_k127_3482464_14 - - - - 0.000000000000000000000000000000001551 131.0
TLS2_k127_3482464_15 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000000000006561 135.0
TLS2_k127_3482464_16 - - - - 0.0000000000000000000001584 106.0
TLS2_k127_3482464_17 - - - - 0.0000000000001854 73.0
TLS2_k127_3482464_18 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.0000000005415 61.0
TLS2_k127_3482464_19 - - - - 0.0000000007944 60.0
TLS2_k127_3482464_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008125 485.0
TLS2_k127_3482464_20 - - - - 0.00003359 51.0
TLS2_k127_3482464_3 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 435.0
TLS2_k127_3482464_4 carboxymethylenebutenolidase activity K01061,K07017 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009837 288.0
TLS2_k127_3482464_5 Phenazine biosynthesis-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001479 272.0
TLS2_k127_3482464_6 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000003881 222.0
TLS2_k127_3482464_7 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000011 216.0
TLS2_k127_3482464_8 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000004027 188.0
TLS2_k127_3482464_9 - - - - 0.000000000000000000000000000000000000000000000006196 180.0
TLS2_k127_3500248_0 Amidohydrolase - - - 0.000000000000001051 89.0
TLS2_k127_3500248_1 short-chain dehydrogenase reductase K00059 - 1.1.1.100 0.000000000001075 70.0
TLS2_k127_352434_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 557.0
TLS2_k127_352434_1 Belongs to the aldehyde dehydrogenase family K22187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 475.0
TLS2_k127_352434_10 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000000000000000000519 157.0
TLS2_k127_352434_11 YHS domain K06966 - 3.2.2.10 0.0000000000000000000000000000000000000002539 155.0
TLS2_k127_352434_12 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000102 152.0
TLS2_k127_352434_13 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000000000008486 160.0
TLS2_k127_352434_14 Amidohydrolase K03392 - 4.1.1.45 0.0000000000000000000000000000000000005397 153.0
TLS2_k127_352434_15 protein possibly involved in utilization of glycolate and propanediol - - - 0.000000000000000000000000000000000004276 141.0
TLS2_k127_352434_16 -acetyltransferase - - - 0.0000000000000000000000000000004271 129.0
TLS2_k127_352434_17 Metallo-beta-lactamase superfamily - - - 0.000000000000000000184 100.0
TLS2_k127_352434_18 Cupin 2, conserved barrel domain protein K11312 - - 0.0000000000000000002349 91.0
TLS2_k127_352434_19 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.0000000003181 67.0
TLS2_k127_352434_2 Bile acid-inducible L-carnitine dehydratase protein F - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004891 387.0
TLS2_k127_352434_20 PFAM major facilitator superfamily MFS_1 - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000001498 66.0
TLS2_k127_352434_21 Tyrosine phosphatase family - - - 0.00001039 56.0
TLS2_k127_352434_22 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00001555 56.0
TLS2_k127_352434_23 HEAT repeats - - - 0.000133 54.0
TLS2_k127_352434_3 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 374.0
TLS2_k127_352434_4 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004029 224.0
TLS2_k127_352434_5 Belongs to the phosphoglycerate mutase family K15634 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000004091 220.0
TLS2_k127_352434_6 Dehydratase K14449,K18290 - 4.2.1.148,4.2.1.56 0.0000000000000000000000000000000000000000000000000000000000175 210.0
TLS2_k127_352434_7 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000008384 200.0
TLS2_k127_352434_8 ribonucleoside-diphosphate reductase activity K07735 - - 0.0000000000000000000000000000000000000000000000000001177 196.0
TLS2_k127_352434_9 to the N-terminal domain of Lon protease K01338,K07157 - 3.4.21.53 0.000000000000000000000000000000000000000007987 163.0
TLS2_k127_3528775_0 Adenosine specific kinase K09129 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001913 259.0
TLS2_k127_3528775_1 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01885,K01894 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000003884 263.0
TLS2_k127_3528775_10 - - - - 0.0000000000000000000007766 103.0
TLS2_k127_3528775_11 COGs COG0589 Universal stress protein UspA and related nucleotide-binding protein - - - 0.0000000000000000002499 93.0
TLS2_k127_3528775_12 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000003256 93.0
TLS2_k127_3528775_13 cheY-homologous receiver domain - - - 0.000000000000002151 83.0
TLS2_k127_3528775_14 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - 0.00004708 53.0
TLS2_k127_3528775_2 3'-5' exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000005198 257.0
TLS2_k127_3528775_4 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000002219 167.0
TLS2_k127_3528775_5 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000000000001668 161.0
TLS2_k127_3528775_6 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000001023 159.0
TLS2_k127_3528775_7 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000119 145.0
TLS2_k127_3528775_8 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000001236 141.0
TLS2_k127_3528775_9 protein conserved in bacteria - - - 0.000000000000000000000000000003228 134.0
TLS2_k127_356556_0 Conserved carboxylase domain K01571 - 4.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004844 370.0
TLS2_k127_356556_1 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K00058 - 1.1.1.26,1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000009318 158.0
TLS2_k127_356556_2 Alkylhydroperoxidase AhpD family core domain-containing protein 7 - - - 0.00000000000000000000000000000000000008749 147.0
TLS2_k127_356556_3 4,5-dihydroxyphthalate decarboxylase - - - 0.0000000000000000000000000001437 127.0
TLS2_k127_356556_4 Polysaccharide deacetylase K01452 - 3.5.1.41 0.00002173 48.0
TLS2_k127_3573716_0 ABC transporter - - - 2.765e-223 704.0
TLS2_k127_3573716_1 mechanosensitive ion channel activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 571.0
TLS2_k127_3573716_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000004357 182.0
TLS2_k127_3573716_11 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000002347 181.0
TLS2_k127_3573716_12 methylamine metabolic process K15977 - - 0.00000000000000000000000000000000006321 137.0
TLS2_k127_3573716_13 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000003241 142.0
TLS2_k127_3573716_14 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000004656 118.0
TLS2_k127_3573716_15 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000002614 109.0
TLS2_k127_3573716_16 NMT1-like family K02051 - - 0.0000000000000000000006143 108.0
TLS2_k127_3573716_17 Transcriptional regulator - - - 0.000000000000000000313 97.0
TLS2_k127_3573716_18 COG0346 Lactoylglutathione lyase and related lyases K21253,K21264,K21265 - 2.5.1.18 0.00000000000000334 81.0
TLS2_k127_3573716_19 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00000000000001029 85.0
TLS2_k127_3573716_2 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 483.0
TLS2_k127_3573716_20 - - - - 0.00000000000001533 76.0
TLS2_k127_3573716_21 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.000000000003938 78.0
TLS2_k127_3573716_22 ABC transporter (Periplasmic binding protein) K02051 - - 0.000000001545 69.0
TLS2_k127_3573716_23 serine threonine protein kinase - - - 0.0000001025 63.0
TLS2_k127_3573716_24 NMT1-like family K02051,K15551 - - 0.00007879 54.0
TLS2_k127_3573716_3 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008095 473.0
TLS2_k127_3573716_4 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 472.0
TLS2_k127_3573716_5 Belongs to the UbiD family K03182,K16874 - 4.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007179 467.0
TLS2_k127_3573716_6 NAD(P)H-binding K01784,K02473 - 5.1.3.2,5.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005293 364.0
TLS2_k127_3573716_7 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 361.0
TLS2_k127_3573716_8 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006313 283.0
TLS2_k127_3573716_9 Arginine-tRNA-protein transferase, C terminus - - - 0.000000000000000000000000000000000000000000000000000007617 197.0
TLS2_k127_3576317_0 COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005603 414.0
TLS2_k127_3576317_1 PFAM Formylglycine-generating sulfatase enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000004753 233.0
TLS2_k127_3576317_2 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000002506 196.0
TLS2_k127_3576317_3 NMT1/THI5 like K02051 - - 0.00000000000002209 84.0
TLS2_k127_3576317_4 NMT1-like family K02051 - - 0.000000000237 72.0
TLS2_k127_35894_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 516.0
TLS2_k127_35894_1 PFAM phosphoesterase, RecJ domain protein K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 491.0
TLS2_k127_35894_10 PFAM phospholipase Carboxylesterase K06999 - - 0.0000000000000000000000000000000000255 143.0
TLS2_k127_35894_11 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000007953 121.0
TLS2_k127_35894_12 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.000000000000000000000000004452 113.0
TLS2_k127_35894_13 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.0000000000000000002219 89.0
TLS2_k127_35894_14 redox protein, regulator of disulfide bond formation - - - 0.000000648 58.0
TLS2_k127_35894_15 Tetratricopeptide repeat protein - - - 0.000002028 61.0
TLS2_k127_35894_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 452.0
TLS2_k127_35894_3 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008723 403.0
TLS2_k127_35894_4 Putative ATP-binding cassette K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 384.0
TLS2_k127_35894_5 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000023 288.0
TLS2_k127_35894_6 spermidine synthase activity K00797 GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007421 302.0
TLS2_k127_35894_7 SecD/SecF GG Motif K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001777 278.0
TLS2_k127_35894_8 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000001651 268.0
TLS2_k127_35894_9 PFAM transglutaminase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002689 268.0
TLS2_k127_3618641_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 571.0
TLS2_k127_3618641_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 438.0
TLS2_k127_3618641_10 NMT1-like family K02051 - - 0.00000000008089 74.0
TLS2_k127_3618641_11 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.00000005049 54.0
TLS2_k127_3618641_12 F420H(2)-dependent quinone reductase - - - 0.0000001403 58.0
TLS2_k127_3618641_13 Phosphodiester glycosidase - - - 0.0002365 53.0
TLS2_k127_3618641_2 proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000006608 230.0
TLS2_k127_3618641_3 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000001322 233.0
TLS2_k127_3618641_4 alkylbase DNA N-glycosylase activity K03652 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000001926 218.0
TLS2_k127_3618641_5 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000004248 198.0
TLS2_k127_3618641_6 phosphatase activity K05967 - - 0.000000000000000000000000000000000000001483 155.0
TLS2_k127_3618641_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.0000000000000000000000002731 111.0
TLS2_k127_3618641_9 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000003847 83.0
TLS2_k127_3659045_0 PFAM NAD dependent epimerase dehydratase family K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 320.0
TLS2_k127_3659045_1 Protein of unknown function (DUF1722) - - - 0.000000000000000000000000102 108.0
TLS2_k127_3659045_2 Cobalamin B12-binding domain protein - - - 0.0000004291 56.0
TLS2_k127_3749147_0 Amidohydrolase K01686 - 4.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 439.0
TLS2_k127_3749147_1 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 436.0
TLS2_k127_3749147_2 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000001587 190.0
TLS2_k127_3749147_3 PFAM Prolyl oligopeptidase family - - - 0.00000000000000000000000003757 109.0
TLS2_k127_375249_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 1.807e-249 795.0
TLS2_k127_375249_1 PFAM tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 7.528e-196 621.0
TLS2_k127_375249_10 - - - - 0.000009878 53.0
TLS2_k127_375249_2 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 539.0
TLS2_k127_375249_3 PFAM Integrase catalytic region K07497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006279 317.0
TLS2_k127_375249_4 epimerase K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000008474 223.0
TLS2_k127_375249_5 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000004405 199.0
TLS2_k127_375249_6 Cupin domain K11312 - - 0.0000000000000000000000000001198 118.0
TLS2_k127_375249_7 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000007668 117.0
TLS2_k127_375249_8 Major Facilitator Superfamily - - - 0.000000000000000000000001834 117.0
TLS2_k127_375249_9 Transposase K07483 - - 0.0000000000000000403 82.0
TLS2_k127_3755577_0 PFAM Peptidase M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001142 249.0
TLS2_k127_3755577_1 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000005104 211.0
TLS2_k127_3755577_2 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000009752 108.0
TLS2_k127_3770063_0 proline dipeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004626 555.0
TLS2_k127_3770063_1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K21417 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003119 525.0
TLS2_k127_3770063_2 PFAM dehydrogenase E1 component K21416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 473.0
TLS2_k127_3770063_3 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 447.0
TLS2_k127_3770063_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 406.0
TLS2_k127_3770063_5 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 378.0
TLS2_k127_3770063_6 membrane transporter protein K07090 - - 0.000000000000002595 83.0
TLS2_k127_3782738_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07306,K08352 - 1.8.5.3,1.8.5.5 4.873e-218 702.0
TLS2_k127_3782738_1 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K16319,K18074 - 1.14.12.1,1.14.12.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 417.0
TLS2_k127_3782738_2 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000005664 202.0
TLS2_k127_3782738_3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor K16303,K16320,K18075,K18243 - 1.14.12.1,1.14.12.15,1.14.12.25,1.14.13.172 0.0000000000000000000000000000000000000000000007344 170.0
TLS2_k127_3782738_4 FAD binding domain K07077 - - 0.000000000000000000000004568 114.0
TLS2_k127_3782738_5 Kdo2-lipid A biosynthetic process K02517 - 2.3.1.241 0.0000088 57.0
TLS2_k127_381149_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 1.317e-211 681.0
TLS2_k127_381149_1 Tripartite tricarboxylate transporter TctA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 526.0
TLS2_k127_381149_10 KR domain - - - 0.00000000000000000000000000000000000000000000001598 178.0
TLS2_k127_381149_11 Response regulator receiver - - - 0.0000000000000000000000000279 113.0
TLS2_k127_381149_2 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 479.0
TLS2_k127_381149_3 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 428.0
TLS2_k127_381149_4 Belongs to the UbiD family K03182 - 4.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005062 399.0
TLS2_k127_381149_5 Peptidase M16 K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 383.0
TLS2_k127_381149_6 PFAM Chlorite dismutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 346.0
TLS2_k127_381149_7 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000000000000000000000000004076 223.0
TLS2_k127_381149_8 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000003534 216.0
TLS2_k127_381149_9 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000001854 201.0
TLS2_k127_3828024_0 glutamate--cysteine ligase K01919 - 6.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004398 417.0
TLS2_k127_3828024_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005482 406.0
TLS2_k127_3828024_10 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000002844 156.0
TLS2_k127_3828024_11 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000006947 125.0
TLS2_k127_3828024_12 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000005891 89.0
TLS2_k127_3828024_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 335.0
TLS2_k127_3828024_3 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009409 321.0
TLS2_k127_3828024_4 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000958 283.0
TLS2_k127_3828024_5 Deoxynucleoside kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004531 248.0
TLS2_k127_3828024_6 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.000000000000000000000000000000000000000000000000000001502 195.0
TLS2_k127_3828024_7 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000003237 177.0
TLS2_k127_3828024_8 major facilitator superfamily - - - 0.00000000000000000000000000000000000000001996 168.0
TLS2_k127_3828024_9 major facilitator superfamily - - - 0.00000000000000000000000000000000000003445 158.0
TLS2_k127_3847482_0 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000004685 202.0
TLS2_k127_3847482_1 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000004319 137.0
TLS2_k127_3847482_2 PIN domain - - - 0.000000000000000001033 93.0
TLS2_k127_3861535_0 TRCF K03723 - - 8.189e-317 1007.0
TLS2_k127_3861535_1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 617.0
TLS2_k127_3861535_2 AMP-binding enzyme C-terminal domain K01895 GO:0003674,GO:0003824,GO:0003996,GO:0004321,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001246 290.0
TLS2_k127_3861535_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000001168 219.0
TLS2_k127_3861535_4 TIR domain - - - 0.00000000000000000000000000000000000000000000001897 189.0
TLS2_k127_3861535_5 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000001327 179.0
TLS2_k127_3861535_6 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000002259 123.0
TLS2_k127_3861535_7 FAD dependent oxidoreductase K00244 - 1.3.5.4 0.0000000000000000003293 95.0
TLS2_k127_3861535_8 Domain of unknown function (DUF309) K09763 - - 0.0000000003016 65.0
TLS2_k127_3916415_0 S-adenosyl-L-methionine-dependent methyltransferase K00773 - 2.4.2.29 5.219e-297 926.0
TLS2_k127_3916415_1 TrkA-N domain - - - 2.647e-200 641.0
TLS2_k127_3916415_10 acetyl-coa acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 301.0
TLS2_k127_3916415_11 PFAM 2-nitropropane dioxygenase NPD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001306 289.0
TLS2_k127_3916415_12 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005317 244.0
TLS2_k127_3916415_13 Belongs to the enoyl-CoA hydratase isomerase family K18383 - 4.1.2.41,4.2.1.101 0.000000000000000000000000000000000000000000000000000000000000000009302 234.0
TLS2_k127_3916415_14 DTW - - - 0.000000000000000000000000000000000000000000000000000000000000001182 225.0
TLS2_k127_3916415_15 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000001609 233.0
TLS2_k127_3916415_16 3-hydroxyacyl-CoA dehydrogenase K00074,K15016,K15019 GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0043956 1.1.1.157,1.1.1.35,4.2.1.116,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000003224 223.0
TLS2_k127_3916415_17 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000001161 219.0
TLS2_k127_3916415_18 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000004467 220.0
TLS2_k127_3916415_19 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000001517 213.0
TLS2_k127_3916415_2 TRAP transporter, 4TM 12TM fusion protein - - - 4.615e-200 642.0
TLS2_k127_3916415_20 PFAM amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000003879 204.0
TLS2_k127_3916415_21 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000001229 200.0
TLS2_k127_3916415_22 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000003595 200.0
TLS2_k127_3916415_23 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000004709 198.0
TLS2_k127_3916415_24 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000155 194.0
TLS2_k127_3916415_25 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000001662 188.0
TLS2_k127_3916415_26 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000005746 185.0
TLS2_k127_3916415_27 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000001301 187.0
TLS2_k127_3916415_28 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000001461 186.0
TLS2_k127_3916415_29 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000001471 187.0
TLS2_k127_3916415_3 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 458.0
TLS2_k127_3916415_30 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000001974 188.0
TLS2_k127_3916415_31 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000005389 186.0
TLS2_k127_3916415_32 conserved protein, contains double-stranded beta-helix domain - - - 0.0000000000000000000000000000000000000000000002039 179.0
TLS2_k127_3916415_33 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000006907 178.0
TLS2_k127_3916415_34 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000009571 177.0
TLS2_k127_3916415_35 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000001326 168.0
TLS2_k127_3916415_36 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000001826 165.0
TLS2_k127_3916415_37 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000002516 136.0
TLS2_k127_3916415_38 NMT1-like family - - - 0.0000000000000000000000000001882 128.0
TLS2_k127_3916415_39 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.0000000000000000000000001138 114.0
TLS2_k127_3916415_4 Mediates influx of magnesium ions K03284,K16074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 454.0
TLS2_k127_3916415_40 NMT1-like family - - - 0.000000000006057 77.0
TLS2_k127_3916415_41 Tripartite tricarboxylate transporter TctA family - - - 0.0000000000856 69.0
TLS2_k127_3916415_42 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.0009872 52.0
TLS2_k127_3916415_5 TRAP transporter, solute receptor (TAXI family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009922 391.0
TLS2_k127_3916415_6 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 375.0
TLS2_k127_3916415_7 2-methylcitrate dehydratase K01720 - 4.2.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 357.0
TLS2_k127_3916415_8 TIM-barrel fold metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 321.0
TLS2_k127_3916415_9 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 319.0
TLS2_k127_3927527_0 PFAM ABC transporter related K06020 - 3.6.3.25 9.833e-293 906.0
TLS2_k127_3927527_1 alpha amylase catalytic K01208 - 3.2.1.133,3.2.1.135,3.2.1.54 2.263e-290 899.0
TLS2_k127_3927527_10 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000001073 191.0
TLS2_k127_3927527_12 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000002346 156.0
TLS2_k127_3927527_13 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000003606 141.0
TLS2_k127_3927527_14 4,5-dihydroxyphthalate decarboxylase K04102 - 4.1.1.55 0.00000000000000000000000000000000001802 148.0
TLS2_k127_3927527_15 sodium-dependent phosphate transmembrane transporter activity K14683 - - 0.000000000000000002099 94.0
TLS2_k127_3927527_16 - - - - 0.00000001502 58.0
TLS2_k127_3927527_17 - - - - 0.00000007305 55.0
TLS2_k127_3927527_18 Mycolic acid cyclopropane synthetase - - - 0.0000002227 61.0
TLS2_k127_3927527_19 Bacterial extracellular solute-binding protein - - - 0.00001508 51.0
TLS2_k127_3927527_2 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K00087 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 462.0
TLS2_k127_3927527_3 MmgE/PrpD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 349.0
TLS2_k127_3927527_4 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 351.0
TLS2_k127_3927527_5 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 296.0
TLS2_k127_3927527_6 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000005161 258.0
TLS2_k127_3927527_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007268 252.0
TLS2_k127_3927527_8 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000002553 226.0
TLS2_k127_3927527_9 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000004712 214.0
TLS2_k127_3929427_0 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000001901 230.0
TLS2_k127_3929427_1 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000001806 226.0
TLS2_k127_3929427_2 FAD binding domain K05712,K10676 - 1.14.13.127,1.14.13.20 0.00000001284 57.0
TLS2_k127_3929427_3 Transposase IS200 like K07491 - - 0.0000001295 61.0
TLS2_k127_3929427_4 4,5-dihydroxyphthalate decarboxylase K04102 - 4.1.1.55 0.00001538 55.0
TLS2_k127_3939289_0 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009908 312.0
TLS2_k127_3939289_1 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000001139 214.0
TLS2_k127_3952171_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1540.0
TLS2_k127_3952171_1 MacB-like periplasmic core domain K02004 - - 8.337e-215 696.0
TLS2_k127_3952171_10 COGs COG0596 hydrolase or acyltransferase (alpha beta hydrolase superfamily) K01055 - 3.1.1.24 0.000000000000000000002129 102.0
TLS2_k127_3952171_2 Aminopeptidase K01256,K08776 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.2 2.847e-212 688.0
TLS2_k127_3952171_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 456.0
TLS2_k127_3952171_4 Biotin-lipoyl like K01993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000413 379.0
TLS2_k127_3952171_5 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008812 283.0
TLS2_k127_3952171_6 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000001229 264.0
TLS2_k127_3952171_7 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000002075 227.0
TLS2_k127_3952171_8 N-terminal half of MaoC dehydratase K09709,K18291 - 4.2.1.153,4.2.1.56 0.00000000000000000000000000000000000000000000000000000000000003874 224.0
TLS2_k127_3952171_9 transcriptional regulator K09017 - - 0.00000000000000000000000000000000000000000000000000000000001303 213.0
TLS2_k127_3982353_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01577,K01652,K03852 - 2.2.1.6,2.3.3.15,4.1.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007076 604.0
TLS2_k127_3982353_1 PFAM Integral membrane protein TerC K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 395.0
TLS2_k127_3982353_10 Protein of unknown function (DUF2283) - - - 0.000000000000000000000000003035 112.0
TLS2_k127_3982353_11 DUF218 domain - - - 0.000000000000000000000000003786 121.0
TLS2_k127_3982353_12 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - 0.00000000000000000001671 103.0
TLS2_k127_3982353_13 Protein of unknown function (DUF433) - - - 0.0000000000000000001933 90.0
TLS2_k127_3982353_14 - - - - 0.0000000000000000004505 90.0
TLS2_k127_3982353_15 thiamine-containing compound biosynthetic process K02051 - - 0.00000001192 64.0
TLS2_k127_3982353_16 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00000005568 64.0
TLS2_k127_3982353_17 NMT1-like family K02051 - - 0.0000153 57.0
TLS2_k127_3982353_2 acetamidase formamidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 304.0
TLS2_k127_3982353_3 maleylacetoacetate isomerase K01801 - 5.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000007014 263.0
TLS2_k127_3982353_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008205 263.0
TLS2_k127_3982353_5 KR domain K03366 - 1.1.1.304,1.1.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000009382 256.0
TLS2_k127_3982353_6 Lactoylglutathione lyase K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000208 219.0
TLS2_k127_3982353_7 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000001369 161.0
TLS2_k127_3982353_8 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000001806 143.0
TLS2_k127_3982353_9 Isochorismatase family - - - 0.00000000000000000000000000009062 123.0
TLS2_k127_3989692_0 dead deah K03724 - - 0.0 1405.0
TLS2_k127_3989692_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 7.588e-274 852.0
TLS2_k127_3989692_10 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 430.0
TLS2_k127_3989692_11 PFAM PfkB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 379.0
TLS2_k127_3989692_12 Catalyzes the reversible oxidation of malate to oxaloacetate K00016,K00024 - 1.1.1.27,1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 368.0
TLS2_k127_3989692_13 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004182 360.0
TLS2_k127_3989692_14 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 347.0
TLS2_k127_3989692_15 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006791 342.0
TLS2_k127_3989692_16 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 292.0
TLS2_k127_3989692_17 Cytochrome C assembly protein K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.000000000000000000000000000000000000000000000000000000000000000000000000001773 267.0
TLS2_k127_3989692_18 TIGRFAM signal peptidase I K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000001901 253.0
TLS2_k127_3989692_19 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000126 198.0
TLS2_k127_3989692_2 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 2.873e-205 647.0
TLS2_k127_3989692_20 Thioredoxin-like K02199,K03671 - - 0.0000000000000000000000000000000000000000000000000009718 189.0
TLS2_k127_3989692_21 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000001601 192.0
TLS2_k127_3989692_22 CcmB protein K02193,K02194 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 0.0000000000000000000000000000000000000000000000005887 183.0
TLS2_k127_3989692_23 Class II Aldolase and Adducin N-terminal domain K03077 - 5.1.3.4 0.0000000000000000000000000000000000000000000001194 177.0
TLS2_k127_3989692_24 intermembrane phospholipid transfer K07323 - - 0.0000000000000000000000000000000000000001608 157.0
TLS2_k127_3989692_25 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.00000000000000000000000000000000000001469 154.0
TLS2_k127_3989692_26 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000001252 138.0
TLS2_k127_3989692_27 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.000000000000000000000000000000177 128.0
TLS2_k127_3989692_28 subunit of a heme lyase - - - 0.000000000000000000000000000005002 137.0
TLS2_k127_3989692_29 PFAM Conserved TM helix repeat-containing protein - - - 0.00000000000000000000000000005765 124.0
TLS2_k127_3989692_3 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000428 581.0
TLS2_k127_3989692_30 Domain of unknown function (DUF368) K08974 - - 0.000000000000000000000000004686 123.0
TLS2_k127_3989692_31 Glycosyltransferase like family 2 K00721 GO:0000271,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0030258,GO:0030259,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.83 0.000000000000000000003736 106.0
TLS2_k127_3989692_32 - - - - 0.0000000004444 65.0
TLS2_k127_3989692_33 Glycosyltransferase like family 2 K10012 - 2.4.2.53 0.000000004335 58.0
TLS2_k127_3989692_34 - - - - 0.0000004634 57.0
TLS2_k127_3989692_4 PFAM Cytochrome C assembly protein K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 572.0
TLS2_k127_3989692_5 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006738 540.0
TLS2_k127_3989692_6 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 514.0
TLS2_k127_3989692_7 GDP-mannose 4,6 dehydratase K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003906 477.0
TLS2_k127_3989692_8 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 430.0
TLS2_k127_3989692_9 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 434.0
TLS2_k127_4025835_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000001088 144.0
TLS2_k127_4025835_1 peptidase activity - - - 0.0000000000000000000000000000002098 132.0
TLS2_k127_4053724_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 2.046e-248 775.0
TLS2_k127_4053724_1 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008028 535.0
TLS2_k127_4053724_2 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 430.0
TLS2_k127_4058084_0 elongation factor Tu domain 2 protein K06207 - - 5.163e-232 737.0
TLS2_k127_4058084_1 (ABC) transporter K06147,K18890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 567.0
TLS2_k127_4058084_10 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000008836 168.0
TLS2_k127_4058084_11 translation initiation factor activity K06996 - - 0.0000000000000000000000000000000000009151 141.0
TLS2_k127_4058084_2 ABC transporter transmembrane region K18889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 456.0
TLS2_k127_4058084_3 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008438 400.0
TLS2_k127_4058084_4 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007533 362.0
TLS2_k127_4058084_5 Surface antigen K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 331.0
TLS2_k127_4058084_6 Putative aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000001552 214.0
TLS2_k127_4058084_7 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.0000000000000000000000000000000000000000000000000000006628 197.0
TLS2_k127_4058084_8 Protein of unknown function (DUF1318) - - - 0.00000000000000000000000000000000000000000000000496 178.0
TLS2_k127_4058084_9 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000000000000000000000000008346 195.0
TLS2_k127_4115386_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 341.0
TLS2_k127_4115386_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003289 312.0
TLS2_k127_4115386_2 NMT1-like family K02051 - - 0.00000003448 65.0
TLS2_k127_4128285_0 UPF0365 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 498.0
TLS2_k127_4128285_1 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 412.0
TLS2_k127_4142970_0 Leucyl-tRNA synthetase, Domain 2 K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1121.0
TLS2_k127_4142970_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 1.611e-306 953.0
TLS2_k127_4142970_10 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001676 236.0
TLS2_k127_4142970_11 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000007652 220.0
TLS2_k127_4142970_12 NUDIX domain K00077,K01092,K03574,K03795 - 1.1.1.169,3.1.3.25,3.6.1.55,4.99.1.3 0.0000000000000000000000000000000000000000000000000000000000003959 215.0
TLS2_k127_4142970_13 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000002704 220.0
TLS2_k127_4142970_14 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000007303 209.0
TLS2_k127_4142970_15 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000212 208.0
TLS2_k127_4142970_16 Lumazine binding domain K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000001984 200.0
TLS2_k127_4142970_17 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000000009137 196.0
TLS2_k127_4142970_18 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000644 187.0
TLS2_k127_4142970_19 TIGRFAM sugar-phosphate isomerase, RpiB LacA LacB family K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000007433 175.0
TLS2_k127_4142970_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.654e-200 631.0
TLS2_k127_4142970_20 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000000000000000000000000000004691 146.0
TLS2_k127_4142970_21 DinB superfamily K18912 - 1.14.99.50 0.000000000000000000000000000000000005461 149.0
TLS2_k127_4142970_22 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000003387 134.0
TLS2_k127_4142970_23 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000003391 134.0
TLS2_k127_4142970_24 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000002156 123.0
TLS2_k127_4142970_25 - - - - 0.00000000000000000000000000001309 124.0
TLS2_k127_4142970_26 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000009725 117.0
TLS2_k127_4142970_27 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.000000000000000000000000827 105.0
TLS2_k127_4142970_28 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.0000000000000000000000008447 106.0
TLS2_k127_4142970_29 Ribosomal L32p protein family K02911 - - 0.0000000000000001225 85.0
TLS2_k127_4142970_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 457.0
TLS2_k127_4142970_30 Lipopolysaccharide-assembly - - - 0.000000000000001323 84.0
TLS2_k127_4142970_31 Redoxin K03564 - 1.11.1.15 0.0000000000001079 76.0
TLS2_k127_4142970_32 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000007021 64.0
TLS2_k127_4142970_4 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 394.0
TLS2_k127_4142970_5 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 356.0
TLS2_k127_4142970_6 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 360.0
TLS2_k127_4142970_7 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 349.0
TLS2_k127_4142970_8 SMART Elongator protein 3 MiaB NifB K07139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 306.0
TLS2_k127_4142970_9 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000125 284.0
TLS2_k127_4210415_1 ethanolamine utilization protein K04019 GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009,GO:0071704,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000003507 259.0
TLS2_k127_4210415_2 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000001616 125.0
TLS2_k127_4210415_3 EamA-like transporter family - - - 0.000000000000000000000009786 112.0
TLS2_k127_4210415_4 endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000004303 92.0
TLS2_k127_4210415_5 Tripartite tricarboxylate transporter family receptor - - - 0.0000000001089 66.0
TLS2_k127_4210415_6 Transposase IS200 like - - - 0.0000001728 54.0
TLS2_k127_421595_0 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 4.297e-249 798.0
TLS2_k127_421595_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 1.58e-208 664.0
TLS2_k127_421595_10 TIM-barrel fold metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002438 248.0
TLS2_k127_421595_11 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000009265 246.0
TLS2_k127_421595_12 Protein of unknown function (DUF4197) - - - 0.00000000000000000000000000000000000000000000000000000000000000000002073 240.0
TLS2_k127_421595_13 Enoyl-(Acyl carrier protein) reductase K00059,K19550 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000608 217.0
TLS2_k127_421595_14 PFAM short chain dehydrogenase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000002429 214.0
TLS2_k127_421595_15 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls - - - 0.000000000000000000000000000000000000000000000000000008069 206.0
TLS2_k127_421595_16 Belongs to the short-chain dehydrogenases reductases (SDR) family - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - 0.00000000000000000000000000000000000000000000000000001434 197.0
TLS2_k127_421595_17 PFAM short chain dehydrogenase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000002684 196.0
TLS2_k127_421595_18 Pfam Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000001179 192.0
TLS2_k127_421595_19 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000001912 190.0
TLS2_k127_421595_2 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 486.0
TLS2_k127_421595_20 Asp/Glu/Hydantoin racemase K01799 - 5.2.1.1 0.0000000000000000000000000000000000000000000002316 176.0
TLS2_k127_421595_21 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000000000000000000000003664 176.0
TLS2_k127_421595_22 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000001202 165.0
TLS2_k127_421595_23 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.0000000000000000000000000000000000000004077 152.0
TLS2_k127_421595_24 PFAM KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.00000000000000000000000000000000000001407 153.0
TLS2_k127_421595_25 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000004241 152.0
TLS2_k127_421595_26 CAAX protease self-immunity - - - 0.00000000000000000000000000000001488 139.0
TLS2_k127_421595_27 protein conserved in bacteria - - - 0.0000000000000000000000000000000502 130.0
TLS2_k127_421595_28 Evidence 4 Homologs of previously reported genes of K07145,K21481 - 1.14.99.48,1.14.99.57 0.0000000000000000000000000000006979 124.0
TLS2_k127_421595_29 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000000000001045 121.0
TLS2_k127_421595_3 Rieske (2Fe-2S) domain-containing protein K15060 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 436.0
TLS2_k127_421595_30 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000002688 115.0
TLS2_k127_421595_31 Belongs to the BolA IbaG family - - - 0.0000000000000000000001317 99.0
TLS2_k127_421595_32 Cupin domain K00450 - 1.13.11.4 0.000000000000000000000144 110.0
TLS2_k127_421595_33 NMT1-like family K02051 - - 0.00000000000001935 84.0
TLS2_k127_421595_34 NMT1-like family K02051 - - 0.0000000000006762 79.0
TLS2_k127_421595_35 - - - - 0.000000000001633 70.0
TLS2_k127_421595_36 - - - - 0.000000000573 63.0
TLS2_k127_421595_37 - - - - 0.000000001412 61.0
TLS2_k127_421595_39 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.000003571 58.0
TLS2_k127_421595_4 Exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 381.0
TLS2_k127_421595_40 Redoxin - - - 0.000008247 51.0
TLS2_k127_421595_41 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) K05967 - - 0.00002211 54.0
TLS2_k127_421595_5 LysR substrate binding domain K03717 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003791 349.0
TLS2_k127_421595_6 NMT1/THI5 like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004227 347.0
TLS2_k127_421595_7 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 327.0
TLS2_k127_421595_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001515 277.0
TLS2_k127_421595_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004907 276.0
TLS2_k127_4244583_0 ABC-type Fe3 transport system permease component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 421.0
TLS2_k127_4244583_1 Belongs to the ABC transporter superfamily K02010,K02052 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000767 347.0
TLS2_k127_4244583_2 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000006658 122.0
TLS2_k127_4244583_3 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.000001898 59.0
TLS2_k127_4262182_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 6.436e-208 655.0
TLS2_k127_4262182_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007864 420.0
TLS2_k127_4262182_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001383 279.0
TLS2_k127_4262182_3 Cupin domain - - - 0.0000000118 59.0
TLS2_k127_4299478_0 Myo-inositol-1-phosphate synthase, GAPDH domain protein K01858 - 5.5.1.4 7.984e-200 627.0
TLS2_k127_4299478_1 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005465 375.0
TLS2_k127_4299478_2 synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005493 248.0
TLS2_k127_4299478_3 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000001135 219.0
TLS2_k127_4348527_0 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005756 614.0
TLS2_k127_4348527_1 Rhodanese-like domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000002539 256.0
TLS2_k127_4348527_10 NMT1-like family K02051 - - 0.0000000001599 72.0
TLS2_k127_4348527_11 Asp Glu hydantoin racemase K01799 - 5.2.1.1 0.000000004275 66.0
TLS2_k127_4348527_12 acetylesterase activity K01051 - 3.1.1.11 0.00002173 48.0
TLS2_k127_4348527_13 S-Adenosylmethionine synthetase K00789 - 2.5.1.6 0.00008782 48.0
TLS2_k127_4348527_2 oligosaccharyl transferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002416 260.0
TLS2_k127_4348527_3 ABC-type nitrate sulfonate bicarbonate transport system ATPase component K02049,K15555 - - 0.0000000000000000000000000000000000000000000000000000000000000000004473 237.0
TLS2_k127_4348527_4 PFAM amidohydrolase 2 K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000472 226.0
TLS2_k127_4348527_5 methyltransferase - - - 0.0000000000000000000000000000000000000000000228 173.0
TLS2_k127_4348527_6 Histone methylation protein DOT1 - - - 0.000000000000000000000000000000000000000003039 168.0
TLS2_k127_4348527_7 ornithine cyclodeaminase mu-crystallin K01750 - 4.3.1.12 0.000000000000000000000000000000000000000009356 167.0
TLS2_k127_4348527_8 methyltransferase - - - 0.00000000000000001224 91.0
TLS2_k127_4348527_9 ABC transporter (Periplasmic binding protein) K02051 - - 0.000000000006585 78.0
TLS2_k127_4356414_0 Protein tyrosine kinase K08884 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000002452 249.0
TLS2_k127_4356414_1 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000002833 200.0
TLS2_k127_4356414_2 Isocitrate/isopropylmalate dehydrogenase - - - 0.00000000000000000000000000000000000000002076 155.0
TLS2_k127_4383302_0 DDE_Tnp_1-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 433.0
TLS2_k127_4383302_1 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 389.0
TLS2_k127_4383302_10 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000009392 209.0
TLS2_k127_4383302_11 DDE_Tnp_1-associated - - - 0.000000000000000000000000000000000003755 147.0
TLS2_k127_4383302_12 NMT1-like family - - - 0.000000000000000000000000000000000005665 153.0
TLS2_k127_4383302_13 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000001088 146.0
TLS2_k127_4383302_14 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.0000000000000000000000000000003166 136.0
TLS2_k127_4383302_15 - - - - 0.0000000000000003361 81.0
TLS2_k127_4383302_16 Glyoxalase bleomycin resistance protein dioxygenase K01759 - 4.4.1.5 0.0002845 49.0
TLS2_k127_4383302_17 UDP-4-amino-4-deoxy-L-arabinose aminotransferase K13010 - 2.6.1.102 0.0004317 43.0
TLS2_k127_4383302_2 aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 380.0
TLS2_k127_4383302_3 Catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 350.0
TLS2_k127_4383302_4 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 342.0
TLS2_k127_4383302_5 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 357.0
TLS2_k127_4383302_6 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004558 264.0
TLS2_k127_4383302_7 acyl-CoA transferase carnitine dehydratase K18702 - 2.8.3.19 0.000000000000000000000000000000000000000000000000000000000000001775 233.0
TLS2_k127_4383302_8 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000001661 230.0
TLS2_k127_4383302_9 PFAM Acetyltransferase (GNAT) family K03790 - 2.3.1.128 0.0000000000000000000000000000000000000000000000000000000000003624 215.0
TLS2_k127_4388409_0 PFAM PrkA AAA K07180 - - 0.0 1013.0
TLS2_k127_4388409_1 SpoVR family K06415 - - 5.346e-195 619.0
TLS2_k127_4388409_10 Shikimate dehydrogenase substrate binding K00014 - 1.1.1.25 0.000000000000000000000000000000000006064 150.0
TLS2_k127_4388409_11 23S rRNA-intervening sequence protein - - - 0.00000000000000000000000000001788 119.0
TLS2_k127_4388409_12 Transcription termination factor nusG - - - 0.0000000000000000000013 101.0
TLS2_k127_4388409_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000001113 101.0
TLS2_k127_4388409_14 addiction module antidote protein HigA K21498 - - 0.0000000000000001644 84.0
TLS2_k127_4388409_15 maleate cis-trans isomerase K01799 - 5.2.1.1 0.000000000000000474 87.0
TLS2_k127_4388409_16 Cytochrome c K17222 - - 0.000000000000004897 79.0
TLS2_k127_4388409_17 uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center - GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0043446,GO:0043448,GO:0044237,GO:0044248,GO:0071704,GO:1901575 - 0.0000000000006109 78.0
TLS2_k127_4388409_18 Cytochrome c K17222 - - 0.000000001998 61.0
TLS2_k127_4388409_2 Belongs to the UPF0229 family K09786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 522.0
TLS2_k127_4388409_3 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K14161 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 478.0
TLS2_k127_4388409_4 OST-HTH/LOTUS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 434.0
TLS2_k127_4388409_5 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000007623 239.0
TLS2_k127_4388409_6 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000005444 236.0
TLS2_k127_4388409_7 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553,K14160 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000002345 213.0
TLS2_k127_4388409_8 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000004081 209.0
TLS2_k127_4388409_9 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000004982 178.0
TLS2_k127_4398805_0 Non-ribosomal peptide synthetase modules and related - - - 1.583e-253 820.0
TLS2_k127_4398805_1 Thiamine pyrophosphate enzyme, central domain - - - 4.469e-249 781.0
TLS2_k127_4398805_2 Thiamine pyrophosphate enzyme, central domain - - - 5.385e-194 617.0
TLS2_k127_4398805_3 Tetratricopeptide repeat - - - 0.0000009524 59.0
TLS2_k127_448860_0 transport system fused permease components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008845 577.0
TLS2_k127_448860_1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 570.0
TLS2_k127_448860_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.00000000000000001548 86.0
TLS2_k127_448860_11 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000003672 83.0
TLS2_k127_448860_12 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000004777 81.0
TLS2_k127_448860_13 NMT1-like family K02051 - - 0.00000165 59.0
TLS2_k127_448860_2 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 434.0
TLS2_k127_448860_3 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 410.0
TLS2_k127_448860_4 HflC and HflK could encode or regulate a protease K04088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 398.0
TLS2_k127_448860_5 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003962 295.0
TLS2_k127_448860_6 Conserved TM helix - - - 0.00000000000000000000000000000000000000000000002724 181.0
TLS2_k127_448860_7 TRAP transporter solute receptor TAXI family protein - - - 0.00000000000000000000000000000000009844 142.0
TLS2_k127_448860_8 Acts as a magnesium transporter - - - 0.00000000000000000002095 102.0
TLS2_k127_448860_9 membrane-anchored protein conserved in bacteria - - - 0.0000000000000000001688 100.0
TLS2_k127_4506283_0 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006255 355.0
TLS2_k127_4506283_1 ABC-type Fe3 transport system permease component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008076 353.0
TLS2_k127_4506283_2 Rieske (2fe-2S) K15060 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 340.0
TLS2_k127_4506283_3 COG3842 ABC-type spermidine putrescine transport systems, ATPase components K02010,K02017,K15497 - 3.6.3.29,3.6.3.30,3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007876 334.0
TLS2_k127_4506283_4 Bacterial extracellular solute-binding protein K02012 - - 0.00006468 51.0
TLS2_k127_4610208_0 Protein of unknown function (DUF2867) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009622 580.0
TLS2_k127_4610208_1 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 477.0
TLS2_k127_4610208_10 - - - - 0.000000001425 68.0
TLS2_k127_4610208_2 PFAM DNA photolyase, FAD-binding K01669 - 4.1.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006504 473.0
TLS2_k127_4610208_3 Glycosyl transferase family 21 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000933 363.0
TLS2_k127_4610208_4 Carotenoid biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000002353 231.0
TLS2_k127_4610208_5 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000007877 214.0
TLS2_k127_4610208_6 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000002579 182.0
TLS2_k127_4610208_7 geranylgeranyl reductase activity K21401 - 1.3.99.38 0.0000000000000000000000000000000000000003227 168.0
TLS2_k127_4610208_8 Protein of unknown function (DUF1722) - - - 0.000000000000000000000000000000000001878 140.0
TLS2_k127_4610208_9 Methyltransferase - - - 0.00000000000000000000000000000000006386 149.0
TLS2_k127_4616023_0 PFAM Glucose Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 540.0
TLS2_k127_4616023_1 Belongs to the UbiD family K03182,K16874 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 441.0
TLS2_k127_4616023_10 NMT1-like family K02051 - - 0.0002496 52.0
TLS2_k127_4616023_2 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions - - - 0.000000000000000000000000000275 122.0
TLS2_k127_4616023_3 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K21566 - - 0.0000000000000000000000000004524 128.0
TLS2_k127_4616023_4 4 iron, 4 sulfur cluster binding K00528,K05524 - 1.18.1.2,1.19.1.1 0.0000000000000000003501 96.0
TLS2_k127_4616023_5 protein, possibly involved in utilization of glycolate and propanediol - - - 0.0000000000000002712 84.0
TLS2_k127_4616023_6 NMT1-like family K02051 - - 0.000000000001063 79.0
TLS2_k127_4616023_7 transcription regulator containing HTH domain K18831 - - 0.0000000001836 68.0
TLS2_k127_4616023_8 Methyltransferase K02493 - 2.1.1.297 0.000000003131 64.0
TLS2_k127_4616023_9 Reductive dehalogenase subunit - - - 0.000174 53.0
TLS2_k127_4695532_0 COG0471 Di- and tricarboxylate transporters - - - 0.0 1073.0
TLS2_k127_4695532_1 Citrate transporter - - - 9.408e-273 851.0
TLS2_k127_4695532_10 - - - - 0.000000738 58.0
TLS2_k127_4695532_11 mannose-1-phosphate guanylyltransferase activity K00971,K16011 - 2.7.7.13,5.3.1.8 0.000005453 57.0
TLS2_k127_4695532_13 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K12952 - 3.6.3.8 0.0004605 44.0
TLS2_k127_4695532_2 UPF0365 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000397 469.0
TLS2_k127_4695532_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006569 266.0
TLS2_k127_4695532_4 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000004382 185.0
TLS2_k127_4695532_5 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.00000000000000000000000000000000000008333 144.0
TLS2_k127_4695532_6 - - - - 0.0000000000000000000000000000003986 128.0
TLS2_k127_4695532_7 Bacterial protein of unknown function (DUF883) - - - 0.00000000000001849 77.0
TLS2_k127_4695532_8 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000000000126 67.0
TLS2_k127_4695532_9 TIGRFAM YihY family protein (not ribonuclease BN) K07058 - - 0.0000001414 62.0
TLS2_k127_4704680_0 transporter K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 616.0
TLS2_k127_4704680_1 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 463.0
TLS2_k127_4704680_10 Rieske [2Fe-2S] domain K15060 - - 0.00000000000000000000000000000000000000000000000000000000000000001279 240.0
TLS2_k127_4704680_11 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000000000000001036 200.0
TLS2_k127_4704680_12 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000004634 195.0
TLS2_k127_4704680_13 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000003895 191.0
TLS2_k127_4704680_14 Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon K03709 - - 0.00000000000000000000000000000000000000000000001263 179.0
TLS2_k127_4704680_15 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.0000000000000000000000000000000004852 139.0
TLS2_k127_4704680_16 Dihydrodipicolinate synthetase family K01714,K22397 - 4.1.2.28,4.3.3.7 0.00000000000000000000000000000000105 141.0
TLS2_k127_4704680_17 iron ion homeostasis K02012 - - 0.0000000000000000000000000000003587 137.0
TLS2_k127_4704680_18 - - - - 0.000000000000000000000000000003549 122.0
TLS2_k127_4704680_19 phosphonopyruvate decarboxylase K09459 - 4.1.1.82 0.0000000000006346 75.0
TLS2_k127_4704680_2 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 411.0
TLS2_k127_4704680_20 CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.000003697 53.0
TLS2_k127_4704680_21 Iron permease FTR1 family K07243 - - 0.00003554 49.0
TLS2_k127_4704680_3 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006036 404.0
TLS2_k127_4704680_4 Rieske (2fe-2S) K15060 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007609 335.0
TLS2_k127_4704680_5 Rieske (2fe-2S) K15060 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 334.0
TLS2_k127_4704680_6 ATPases associated with a variety of cellular activities K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 329.0
TLS2_k127_4704680_7 Carbon-nitrogen hydrolase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 296.0
TLS2_k127_4704680_8 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006825 282.0
TLS2_k127_4704680_9 Aldolase/RraA - - - 0.000000000000000000000000000000000000000000000000000000000000000000007001 240.0
TLS2_k127_4706466_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07788 - - 0.0 1239.0
TLS2_k127_4706466_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 7.75e-200 647.0
TLS2_k127_4706466_10 Belongs to the UbiD family K16874 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 338.0
TLS2_k127_4706466_11 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 307.0
TLS2_k127_4706466_12 Metallo-beta-lactamase superfamily K01069 GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000211 273.0
TLS2_k127_4706466_13 Enoyl-(Acyl carrier protein) reductase K00059,K00068 - 1.1.1.100,1.1.1.140 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009893 271.0
TLS2_k127_4706466_14 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005189 268.0
TLS2_k127_4706466_15 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001055 251.0
TLS2_k127_4706466_16 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000001363 252.0
TLS2_k127_4706466_17 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000001488 252.0
TLS2_k127_4706466_18 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000001673 219.0
TLS2_k127_4706466_19 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000003003 219.0
TLS2_k127_4706466_2 ABC transporter K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 581.0
TLS2_k127_4706466_20 cob(I)yrinic acid a,c-diamide adenosyltransferase activity K00798,K13821 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.2.1.88,1.5.5.2,2.5.1.17 0.00000000000000000000000000000000000000000000000000000000006812 211.0
TLS2_k127_4706466_21 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000006811 175.0
TLS2_k127_4706466_22 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000000006677 169.0
TLS2_k127_4706466_23 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.00000000000000000000000000000000000008229 149.0
TLS2_k127_4706466_24 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively K04099,K04101 - 1.13.11.57,1.13.11.8 0.000000000000000000000000000000000001618 149.0
TLS2_k127_4706466_25 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000000523 141.0
TLS2_k127_4706466_26 Rhodanese Homology Domain - - - 0.0000000000000000000000000000009457 127.0
TLS2_k127_4706466_27 Photosynthesis system II assembly factor YCF48 - - - 0.00000000000000000000000000001225 132.0
TLS2_k127_4706466_29 Domain of unknown function (DUF1989) K09967 - - 0.000000000000000000002459 102.0
TLS2_k127_4706466_3 Exporters of the RND superfamily K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 545.0
TLS2_k127_4706466_30 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.0000000000000000001165 104.0
TLS2_k127_4706466_31 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000008023 96.0
TLS2_k127_4706466_32 NMT1-like family K02051 - - 0.000000000002905 78.0
TLS2_k127_4706466_33 NMT1-like family K02051 - - 0.0000000003592 71.0
TLS2_k127_4706466_34 - - - - 0.00002144 51.0
TLS2_k127_4706466_35 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.00006325 49.0
TLS2_k127_4706466_36 Tetratricopeptide TPR_2 repeat protein - - - 0.0006963 48.0
TLS2_k127_4706466_4 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 504.0
TLS2_k127_4706466_5 LVIVD repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 412.0
TLS2_k127_4706466_6 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 383.0
TLS2_k127_4706466_7 Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate and vanillate K01612,K16874 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464 4.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 374.0
TLS2_k127_4706466_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004057 370.0
TLS2_k127_4706466_9 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 341.0
TLS2_k127_4719516_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.047e-269 850.0
TLS2_k127_4719516_1 ABC transporter K06147,K18890 - - 1.541e-235 744.0
TLS2_k127_4719516_10 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 523.0
TLS2_k127_4719516_100 Protein of unknown function (DUF3106) - - - 0.0000002452 61.0
TLS2_k127_4719516_102 cellular calcium ion homeostasis - - - 0.0000009579 59.0
TLS2_k127_4719516_103 Tetratricopeptide repeat - - - 0.000003718 57.0
TLS2_k127_4719516_104 HEAT repeats - - - 0.00005332 52.0
TLS2_k127_4719516_105 Tetratricopeptide repeat - - - 0.00008576 51.0
TLS2_k127_4719516_106 Steryl acetyl hydrolase - - - 0.0002123 47.0
TLS2_k127_4719516_107 to Saccharomyces cerevisiae CTR9 (YOL145C) K15176 GO:0000082,GO:0000083,GO:0000278,GO:0000414,GO:0000416,GO:0000428,GO:0000785,GO:0000988,GO:0000989,GO:0000993,GO:0001015,GO:0001076,GO:0001098,GO:0001099,GO:0001932,GO:0001934,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006282,GO:0006351,GO:0006353,GO:0006354,GO:0006355,GO:0006356,GO:0006357,GO:0006360,GO:0006362,GO:0006366,GO:0006368,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0007049,GO:0008023,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009302,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010562,GO:0010604,GO:0010628,GO:0010638,GO:0016070,GO:0016071,GO:0016074,GO:0016591,GO:0016593,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019899,GO:0022402,GO:0030880,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031123,GO:0031124,GO:0031126,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031396,GO:0031399,GO:0031401,GO:0031935,GO:0031938,GO:0031974,GO:0031981,GO:0032268,GO:0032270,GO:0032774,GO:0032784,GO:0032786,GO:0032968,GO:0032991,GO:0033043,GO:0033044,GO:0033182,GO:0034243,GO:0034470,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0035327,GO:0042325,GO:0042327,GO:0043144,GO:0043170,GO:0043175,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043628,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0044877,GO:0045142,GO:0045309,GO:0045893,GO:0045935,GO:0045937,GO:0045943,GO:0045944,GO:0046483,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0050815,GO:0051052,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051219,GO:0051246,GO:0051247,GO:0051252,GO:0051254,GO:0051569,GO:0055029,GO:0060255,GO:0060260,GO:0060968,GO:0061695,GO:0065007,GO:0070013,GO:0070063,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090262,GO:0090304,GO:0097159,GO:0097659,GO:0098781,GO:0099122,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901407,GO:1901409,GO:1901576,GO:1902275,GO:1902494,GO:1902680,GO:1903047,GO:1903320,GO:1903506,GO:1903508,GO:1905269,GO:1990234,GO:1990269,GO:2000112,GO:2000142,GO:2000819,GO:2001020,GO:2001141,GO:2001163,GO:2001165,GO:2001166,GO:2001173,GO:2001207,GO:2001209,GO:2001252,GO:2001253,GO:2001255 - 0.0002179 51.0
TLS2_k127_4719516_11 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004914 502.0
TLS2_k127_4719516_12 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 496.0
TLS2_k127_4719516_13 oxidoreductase activity K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 508.0
TLS2_k127_4719516_14 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006936 465.0
TLS2_k127_4719516_15 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 461.0
TLS2_k127_4719516_16 TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 437.0
TLS2_k127_4719516_17 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009916 437.0
TLS2_k127_4719516_18 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 441.0
TLS2_k127_4719516_19 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 424.0
TLS2_k127_4719516_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 9.019e-230 731.0
TLS2_k127_4719516_20 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009699 424.0
TLS2_k127_4719516_21 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 436.0
TLS2_k127_4719516_22 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 416.0
TLS2_k127_4719516_23 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005089 405.0
TLS2_k127_4719516_24 Associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 389.0
TLS2_k127_4719516_25 Amino acid kinase family K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007951 386.0
TLS2_k127_4719516_26 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 381.0
TLS2_k127_4719516_27 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 377.0
TLS2_k127_4719516_28 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 364.0
TLS2_k127_4719516_29 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 363.0
TLS2_k127_4719516_3 ABC transporter transmembrane region K06147,K18889 - - 4.997e-203 649.0
TLS2_k127_4719516_30 ATPase with chaperone activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 367.0
TLS2_k127_4719516_31 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 375.0
TLS2_k127_4719516_32 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006813 344.0
TLS2_k127_4719516_33 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 356.0
TLS2_k127_4719516_34 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004847 333.0
TLS2_k127_4719516_35 KH domain K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 316.0
TLS2_k127_4719516_36 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 324.0
TLS2_k127_4719516_37 Lipoprotein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000762 310.0
TLS2_k127_4719516_38 Carbon-nitrogen hydrolase K01916 - 6.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008308 306.0
TLS2_k127_4719516_39 TIGRFAM DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 305.0
TLS2_k127_4719516_4 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 1.581e-199 632.0
TLS2_k127_4719516_40 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 301.0
TLS2_k127_4719516_41 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 303.0
TLS2_k127_4719516_42 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 328.0
TLS2_k127_4719516_43 PFAM Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005356 295.0
TLS2_k127_4719516_44 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 290.0
TLS2_k127_4719516_45 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003915 286.0
TLS2_k127_4719516_46 Belongs to the UPF0255 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006125 288.0
TLS2_k127_4719516_47 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001089 273.0
TLS2_k127_4719516_48 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215,K03546 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001241 276.0
TLS2_k127_4719516_49 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001249 262.0
TLS2_k127_4719516_5 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 608.0
TLS2_k127_4719516_50 UbiA prenyltransferase family K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000001115 265.0
TLS2_k127_4719516_51 TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000007573 265.0
TLS2_k127_4719516_52 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.0000000000000000000000000000000000000000000000000000000000000000000000005634 257.0
TLS2_k127_4719516_53 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000006779 251.0
TLS2_k127_4719516_54 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001625 249.0
TLS2_k127_4719516_55 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000003416 253.0
TLS2_k127_4719516_56 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000008344 240.0
TLS2_k127_4719516_57 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.000000000000000000000000000000000000000000000000000000000000004457 232.0
TLS2_k127_4719516_58 KR domain K03366 - 1.1.1.304,1.1.1.76 0.00000000000000000000000000000000000000000000000000000000000002652 223.0
TLS2_k127_4719516_59 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000001871 223.0
TLS2_k127_4719516_6 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009638 606.0
TLS2_k127_4719516_60 ZIP Zinc transporter K16267 - - 0.000000000000000000000000000000000000000000000000000000000001161 217.0
TLS2_k127_4719516_61 Alpha/beta hydrolase of unknown function (DUF1100) - - - 0.000000000000000000000000000000000000000000000000000000000001471 215.0
TLS2_k127_4719516_62 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000002488 220.0
TLS2_k127_4719516_63 TIGRFAM phosphate phosphite phosphonate ABC transporters, periplasmic binding protein K02044 - - 0.00000000000000000000000000000000000000000000000000000000001377 218.0
TLS2_k127_4719516_64 ABC-type Mn2 Zn2 transport systems permease components K02075,K09816 - - 0.0000000000000000000000000000000000000000000000000000000003963 221.0
TLS2_k127_4719516_65 COG3639 ABC-type phosphate phosphonate transport system permease component K02042 - - 0.000000000000000000000000000000000000000000000000000000001946 212.0
TLS2_k127_4719516_66 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000659 207.0
TLS2_k127_4719516_67 Zinc-uptake complex component A periplasmic K09815 - - 0.00000000000000000000000000000000000000000000000000000005744 207.0
TLS2_k127_4719516_68 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000009412 194.0
TLS2_k127_4719516_69 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000003532 196.0
TLS2_k127_4719516_7 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007877 598.0
TLS2_k127_4719516_70 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000001545 182.0
TLS2_k127_4719516_71 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000000000001511 165.0
TLS2_k127_4719516_72 Dopa 4,5-dioxygenase family K10253 - - 0.0000000000000000000000000000000000000000009087 158.0
TLS2_k127_4719516_73 ABC transporter, ATP-binding protein K02074,K09820,K11603,K11710 - - 0.000000000000000000000000000000000000000001097 165.0
TLS2_k127_4719516_74 carboxymuconolactone decarboxylase - - - 0.00000000000000000000000000000000000000002618 158.0
TLS2_k127_4719516_75 Ferric uptake regulator family K03711 - - 0.0000000000000000000000000000000000000007015 151.0
TLS2_k127_4719516_76 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000004592 166.0
TLS2_k127_4719516_77 - - - - 0.00000000000000000000000000000000008477 153.0
TLS2_k127_4719516_78 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000001071 129.0
TLS2_k127_4719516_79 Thioesterase superfamily K10806 - - 0.00000000000000000000000000001179 122.0
TLS2_k127_4719516_8 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 550.0
TLS2_k127_4719516_80 phosphate-selective porin O and P - - - 0.00000000000000000000000000005426 131.0
TLS2_k127_4719516_81 Binds the 23S rRNA K02909 GO:0008150,GO:0040007 - 0.00000000000000000000000000006933 116.0
TLS2_k127_4719516_82 RNA recognition motif - - - 0.0000000000000000000000000001041 119.0
TLS2_k127_4719516_83 regulation of translation K03530,K05788 - - 0.0000000000000000000000000002649 115.0
TLS2_k127_4719516_84 Alpha beta-Hydrolases superfamily protein K06889 - - 0.0000000000000000000000000003336 124.0
TLS2_k127_4719516_85 Protein of unknown function (DUF3299) K09950 - - 0.000000000000000000000000000494 121.0
TLS2_k127_4719516_86 von Willebrand factor, type A - - - 0.00000000000000000000000000396 128.0
TLS2_k127_4719516_87 Putative prokaryotic signal transducing protein - - - 0.000000000000000000000000004272 115.0
TLS2_k127_4719516_88 oligosaccharyl transferase activity - - - 0.0000000000000000000000003271 121.0
TLS2_k127_4719516_89 Acylphosphatase - - - 0.000000000000000000000003579 104.0
TLS2_k127_4719516_9 Argininosuccinate lyase C-terminal K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 552.0
TLS2_k127_4719516_90 zinc ion transport K00341,K02077,K09121,K09796 - 1.6.5.3,4.99.1.12 0.00000000000000000001688 98.0
TLS2_k127_4719516_91 thiolester hydrolase activity K19188 - 3.7.1.19 0.0000000000000000002211 94.0
TLS2_k127_4719516_92 Membrane - - - 0.000000000000000001682 100.0
TLS2_k127_4719516_93 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000002958 94.0
TLS2_k127_4719516_94 Fibronectin type 3 domain - - - 0.00000000000003687 78.0
TLS2_k127_4719516_95 - - - - 0.0000000000001315 78.0
TLS2_k127_4719516_96 Prolyl oligopeptidase family - - - 0.000000000002887 76.0
TLS2_k127_4719516_97 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.000000000301 62.0
TLS2_k127_4719516_98 MerC mercury resistance protein - - - 0.000000002614 65.0
TLS2_k127_4719516_99 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.000000006268 62.0
TLS2_k127_4719593_0 nitrite transmembrane transporter activity K02575,K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004185 265.0
TLS2_k127_4719593_1 NMT1-like family - - - 0.00000000000000000000000000000000000000002274 164.0
TLS2_k127_4777517_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07306,K08352 - 1.8.5.3,1.8.5.5 4.461e-218 700.0
TLS2_k127_4809885_0 CHAT domain - - - 0.0 1641.0
TLS2_k127_4809885_1 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 - - 1.839e-211 669.0
TLS2_k127_4809885_2 Zinc-dependent metalloprotease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005418 516.0
TLS2_k127_4809885_3 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) K05921 - 4.1.1.68 0.000000000000000000000000000000000000000000000000000002793 205.0
TLS2_k127_4809885_4 translation release factor activity - - - 0.0000000000000000000000000000000003521 137.0
TLS2_k127_4809885_5 Major Facilitator Superfamily - - - 0.0000000000000000000000008873 118.0
TLS2_k127_4809885_6 - - - - 0.000000000000000001025 87.0
TLS2_k127_4809885_7 Transcription factor zinc-finger - - - 0.00000000000002272 77.0
TLS2_k127_4809885_8 NMT1-like family K02051 - - 0.000000006526 68.0
TLS2_k127_4809885_9 Major facilitator superfamily K08151 - - 0.0000004698 62.0
TLS2_k127_4880764_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0 1075.0
TLS2_k127_4880764_1 formate dehydrogenase (NAD+) activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 330.0
TLS2_k127_4880764_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.000000000000000000000001768 103.0
TLS2_k127_4897663_0 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 334.0
TLS2_k127_4897663_1 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006951 280.0
TLS2_k127_4897663_2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.1.1.31,1.1.1.60 0.0000000000000000000000000000007836 132.0
TLS2_k127_4897663_3 NMT1-like family - - - 0.00000000000000000000000002404 122.0
TLS2_k127_4897663_4 LVIVD repeat - - - 0.0000001378 54.0
TLS2_k127_4907528_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1191.0
TLS2_k127_4907528_1 Glycosyl transferase, family 2 - - - 0.0 1047.0
TLS2_k127_4907528_10 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 542.0
TLS2_k127_4907528_11 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 529.0
TLS2_k127_4907528_12 PFAM 4-hydroxyphenylacetate 3-hydroxylase K00483 - 1.14.14.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008617 496.0
TLS2_k127_4907528_13 FAD dependent oxidoreductase K00109,K15736 - 1.1.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 489.0
TLS2_k127_4907528_14 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 479.0
TLS2_k127_4907528_15 PFAM peptidase M16 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 415.0
TLS2_k127_4907528_16 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 417.0
TLS2_k127_4907528_17 N-methylhydantoinase B acetone carboxylase, alpha subunit K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009348 394.0
TLS2_k127_4907528_18 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 388.0
TLS2_k127_4907528_19 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 370.0
TLS2_k127_4907528_2 SNF2 family N-terminal domain - - - 6.847e-310 985.0
TLS2_k127_4907528_20 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 359.0
TLS2_k127_4907528_21 Methionyl-tRNA formyltransferase K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008701 331.0
TLS2_k127_4907528_22 membrane-bound metal-dependent K07038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 318.0
TLS2_k127_4907528_23 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 309.0
TLS2_k127_4907528_24 MmgE/PrpD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003326 318.0
TLS2_k127_4907528_25 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006348 305.0
TLS2_k127_4907528_26 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004753 301.0
TLS2_k127_4907528_27 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007477 287.0
TLS2_k127_4907528_28 Pfam Cupin K00450,K11948 - 1.13.11.38,1.13.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 292.0
TLS2_k127_4907528_29 glyoxalase K07032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000723 235.0
TLS2_k127_4907528_3 ATP-dependent helicase C-terminal K03579 - 3.6.4.13 5.853e-305 956.0
TLS2_k127_4907528_30 SMART Extracellular solute-binding protein, family 3 K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000153 234.0
TLS2_k127_4907528_31 Ribosomal protein L11 methyltransferase (PrmA) K15460 - 2.1.1.223 0.0000000000000000000000000000000000000000000000000000000000000003266 228.0
TLS2_k127_4907528_32 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000003522 235.0
TLS2_k127_4907528_33 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000002535 219.0
TLS2_k127_4907528_34 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.0000000000000000000000000000000000000000000000000000000805 201.0
TLS2_k127_4907528_35 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000006723 200.0
TLS2_k127_4907528_36 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000000000000001917 181.0
TLS2_k127_4907528_37 intermembrane phospholipid transfer K07323 - - 0.000000000000000000000000000000000000000000000002712 180.0
TLS2_k127_4907528_38 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000002149 172.0
TLS2_k127_4907528_39 PFAM Mammalian cell entry related domain protein K02067 - - 0.000000000000000000000000000000000000000002898 161.0
TLS2_k127_4907528_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 9.105e-285 892.0
TLS2_k127_4907528_40 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000005527 164.0
TLS2_k127_4907528_41 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000002788 143.0
TLS2_k127_4907528_42 Domain of unknown function (DUF4160) - - - 0.00000000000000000000000000000000002572 136.0
TLS2_k127_4907528_43 SWI complex, BAF60b domains - - - 0.00000000000000000000000000000000002832 136.0
TLS2_k127_4907528_44 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000008238 128.0
TLS2_k127_4907528_45 Amidohydrolase K03392,K14333,K20941 - 4.1.1.103,4.1.1.45,4.1.1.46 0.000000000000000000000000003098 123.0
TLS2_k127_4907528_46 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101,K05713 - 1.13.11.16,1.13.11.8 0.00000000000000000000000008463 111.0
TLS2_k127_4907528_47 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000001542 107.0
TLS2_k127_4907528_48 SEC-C motif - - - 0.00000000000000000000000051 108.0
TLS2_k127_4907528_49 Peptidase family M48 - - - 0.0000000000000000000002121 100.0
TLS2_k127_4907528_5 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 1.752e-270 849.0
TLS2_k127_4907528_50 Protein of unknown function (DUF2442) - - - 0.000000000000000000000406 99.0
TLS2_k127_4907528_51 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.000000000000000001947 88.0
TLS2_k127_4907528_52 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000000000000001017 84.0
TLS2_k127_4907528_53 Protein of unknown function (DUF721) - - - 0.000000000000002068 82.0
TLS2_k127_4907528_54 metal-dependent hydrolase of the TIM-barrel fold - - - 0.00000000000000266 79.0
TLS2_k127_4907528_55 NMT1-like family K02051 - - 0.000000000000004636 86.0
TLS2_k127_4907528_56 aspartic-type endopeptidase activity K06985 - - 0.00000000000002974 80.0
TLS2_k127_4907528_57 Amidohydrolase - - - 0.00000000009238 73.0
TLS2_k127_4907528_58 synthetase K01912 - 6.2.1.30 0.0000000001758 66.0
TLS2_k127_4907528_59 WYL domain - - - 0.000000003145 63.0
TLS2_k127_4907528_6 PFAM ABC transporter, transmembrane region K06147,K11085 - - 7.211e-235 741.0
TLS2_k127_4907528_60 - - - - 0.000006658 50.0
TLS2_k127_4907528_61 UPF0056 membrane protein K05595 - - 0.0002306 49.0
TLS2_k127_4907528_62 Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - - 0.0004643 48.0
TLS2_k127_4907528_7 COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 585.0
TLS2_k127_4907528_8 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005006 563.0
TLS2_k127_4907528_9 Transporter K12942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 552.0
TLS2_k127_4928020_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 5.132e-297 932.0
TLS2_k127_4928020_1 Glycosyl hydrolase family 65, C-terminal domain K05342 - 2.4.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005451 535.0
TLS2_k127_4928020_2 FAD-binding domain K00529 - 1.18.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005481 409.0
TLS2_k127_4928020_3 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 0.00000000000000000000000000000000004057 140.0
TLS2_k127_4928020_4 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000003332 144.0
TLS2_k127_4928020_5 Belongs to the universal stress protein A family - - - 0.00000000001718 75.0
TLS2_k127_4928020_6 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.00002668 51.0
TLS2_k127_4928020_7 PFAM Cyclic nucleotide-binding K10914 - - 0.00009075 51.0
TLS2_k127_4972524_0 Tripartite tricarboxylate transporter TctA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 374.0
TLS2_k127_4972524_1 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000001106 131.0
TLS2_k127_5042823_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008354 334.0
TLS2_k127_5096299_0 ABC transporter K15738 - - 2.592e-219 699.0
TLS2_k127_5096299_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002928 323.0
TLS2_k127_5096299_10 MFS/sugar transport protein - - - 0.000000000000000000000000000002002 136.0
TLS2_k127_5096299_11 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000002482 124.0
TLS2_k127_5096299_12 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000003525 106.0
TLS2_k127_5096299_13 Universal stress protein - - - 0.00000000000005601 79.0
TLS2_k127_5096299_14 Elements of external origin - - - 0.00000000003298 64.0
TLS2_k127_5096299_15 Asp/Glu/Hydantoin racemase K01799 - 5.2.1.1 0.000000002196 67.0
TLS2_k127_5096299_16 SMART extracellular solute-binding protein family 3 K02051 - - 0.00000000711 67.0
TLS2_k127_5096299_17 DoxX family K15977 - - 0.00008729 50.0
TLS2_k127_5096299_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000633 321.0
TLS2_k127_5096299_3 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 298.0
TLS2_k127_5096299_4 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006575 252.0
TLS2_k127_5096299_5 Belongs to the enoyl-CoA hydratase isomerase family K18383 - 4.1.2.41,4.2.1.101 0.000000000000000000000000000000000000000000000000000000006641 209.0
TLS2_k127_5096299_6 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000002519 209.0
TLS2_k127_5096299_7 maF-like protein K03215,K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 2.1.1.190 0.00000000000000000000000000000000000000000000000000000004367 203.0
TLS2_k127_5096299_8 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000000000000000000000000000000000000000000001867 186.0
TLS2_k127_5096299_9 MEKHLA domain - - - 0.000000000000000000000000000000000000000000001007 169.0
TLS2_k127_5096394_0 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 397.0
TLS2_k127_5096394_1 Conserved carboxylase domain K01571 - 4.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005288 382.0
TLS2_k127_5096394_10 bleomycin resistance protein - - - 0.000000008323 63.0
TLS2_k127_5096394_11 nuclease activity - - - 0.000001036 57.0
TLS2_k127_5096394_2 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002097 269.0
TLS2_k127_5096394_3 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004097 279.0
TLS2_k127_5096394_4 Sugar (and other) transporter K07552 - - 0.00000000000000000000000000000000000000000000000000000000000003989 229.0
TLS2_k127_5096394_5 major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000008137 221.0
TLS2_k127_5096394_6 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000004431 208.0
TLS2_k127_5096394_7 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000009433 186.0
TLS2_k127_5096394_8 Pfam Amidohydrolase K07045 - - 0.00000000000000000000001017 113.0
TLS2_k127_5096394_9 Elements of external origin - - - 0.00000000002398 64.0
TLS2_k127_5129237_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1161.0
TLS2_k127_5129237_1 Peptidase M20 K01295 - 3.4.17.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004124 393.0
TLS2_k127_5129237_10 Uncharacterised protein family UPF0066 - - - 0.0000000000000000000000000000000000000000000319 166.0
TLS2_k127_5129237_11 Isochorismatase family - - - 0.00000000000000000000000000000000001141 143.0
TLS2_k127_5129237_12 Pfam Amidohydrolase K07045 - - 0.0000000000000000000000000000000003801 145.0
TLS2_k127_5129237_13 TRAP transporter solute receptor TAXI family K07080 - - 0.000000000000000000000000000000001036 141.0
TLS2_k127_5129237_14 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000001082 128.0
TLS2_k127_5129237_15 Cytochrome c K17222 - - 0.00000000000021 76.0
TLS2_k127_5129237_16 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000005146 82.0
TLS2_k127_5129237_17 Belongs to the universal stress protein A family - - - 0.00000000001986 69.0
TLS2_k127_5129237_18 Elements of external origin - - - 0.0000001116 53.0
TLS2_k127_5129237_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 339.0
TLS2_k127_5129237_3 transporter K11021,K16267 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009389 279.0
TLS2_k127_5129237_4 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000000000000000000000000004407 222.0
TLS2_k127_5129237_5 major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000002638 224.0
TLS2_k127_5129237_6 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000002734 213.0
TLS2_k127_5129237_7 major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000001091 206.0
TLS2_k127_5129237_8 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000002086 194.0
TLS2_k127_5129237_9 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000002557 178.0
TLS2_k127_5158758_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1116.0
TLS2_k127_5158758_1 Carbohydrate phosphorylase K00688 - 2.4.1.1 1.88e-233 734.0
TLS2_k127_5158758_10 Sulphur transport - - - 0.000000000000000000000000000000000000000000000000000000000005379 212.0
TLS2_k127_5158758_12 OsmC-like protein - - - 0.000000000000000000000000000002932 125.0
TLS2_k127_5158758_13 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.0000000000000000000000000002063 117.0
TLS2_k127_5158758_14 CBS domain K04767 - - 0.0000000000000000002748 99.0
TLS2_k127_5158758_15 CoA-binding protein K06929 - - 0.000000000001018 79.0
TLS2_k127_5158758_16 - - - - 0.00000004911 59.0
TLS2_k127_5158758_2 N-methylhydantoinase B acetone carboxylase alpha subunit K01474 - 3.5.2.14 1.299e-199 637.0
TLS2_k127_5158758_3 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 571.0
TLS2_k127_5158758_4 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 552.0
TLS2_k127_5158758_5 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008107 472.0
TLS2_k127_5158758_6 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007731 409.0
TLS2_k127_5158758_7 PFAM sodium calcium exchanger membrane region K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 349.0
TLS2_k127_5158758_8 Belongs to the carbamoyltransferase HypF family K04656 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007706 264.0
TLS2_k127_5158758_9 Sulphur transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000735 235.0
TLS2_k127_5172566_0 type III restriction protein res subunit K01153 - 3.1.21.3 0.0 1131.0
TLS2_k127_5172566_1 PFAM DNA methylase N-4 N-6 domain protein K07316 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 638.0
TLS2_k127_5172566_10 Lactoylglutathione lyase K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000005084 196.0
TLS2_k127_5172566_11 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000002679 204.0
TLS2_k127_5172566_12 Protein of unknown function (DUF456) K09793 - - 0.00000000000000000000000000000000000000000000000000009066 190.0
TLS2_k127_5172566_13 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000302 183.0
TLS2_k127_5172566_14 Protein conserved in bacteria K18480 - - 0.000000000000000000000000000000000000000000000005963 180.0
TLS2_k127_5172566_15 TRAP transporter, solute receptor (TAXI family K07080 - - 0.000000000000000000001453 106.0
TLS2_k127_5172566_16 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.00002999 51.0
TLS2_k127_5172566_17 Z1 domain - - - 0.0005311 42.0
TLS2_k127_5172566_2 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 428.0
TLS2_k127_5172566_3 Belongs to the MlaE permease family K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 418.0
TLS2_k127_5172566_4 Amidohydrolase family K15358 - 3.5.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008369 393.0
TLS2_k127_5172566_5 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 346.0
TLS2_k127_5172566_6 Luciferase-like monooxygenase K00320,K14728 - 1.5.98.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 331.0
TLS2_k127_5172566_7 Mammalian cell entry related domain protein K02067,K06192 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001318 269.0
TLS2_k127_5172566_8 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000007622 251.0
TLS2_k127_5172566_9 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000006103 219.0
TLS2_k127_5174160_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00262 GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.4 1.155e-220 691.0
TLS2_k127_5174160_1 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 578.0
TLS2_k127_5174160_10 MlaC protein K07323 - - 0.000000000000000000000000000000000000000004523 162.0
TLS2_k127_5174160_11 enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.0000000000000000000000000000000005217 148.0
TLS2_k127_5174160_12 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000001906 134.0
TLS2_k127_5174160_13 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000002475 130.0
TLS2_k127_5174160_14 Domain of unknown function (DUF1932) - - - 0.00000000000000000000000002054 120.0
TLS2_k127_5174160_15 CoA binding domain - - - 0.000000000000002971 76.0
TLS2_k127_5174160_16 SnoaL-like polyketide cyclase K06893 - - 0.00000004021 64.0
TLS2_k127_5174160_2 Bacterial periplasmic substrate-binding proteins K02029,K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 553.0
TLS2_k127_5174160_3 Major Facilitator Superfamily K08224 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009073 440.0
TLS2_k127_5174160_4 Rubrerythrin K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 284.0
TLS2_k127_5174160_5 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005523 246.0
TLS2_k127_5174160_6 COGs COG2912 conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000003928 235.0
TLS2_k127_5174160_7 [2Fe-2S] binding domain K07302,K18029 - 1.17.2.1,1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000385 220.0
TLS2_k127_5174160_8 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000004559 221.0
TLS2_k127_5174160_9 AAA domain, putative AbiEii toxin, Type IV TA system K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000001601 203.0
TLS2_k127_5178837_0 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 475.0
TLS2_k127_5178837_1 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000003742 145.0
TLS2_k127_5178837_2 Tripartite tricarboxylate transporter TctA family - - - 0.0000004031 58.0
TLS2_k127_5189543_0 COG0526, thiol-disulfide isomerase and thioredoxins - - - 2.06e-201 635.0
TLS2_k127_5189543_1 Glycine reductase complex component B subunit gamma K10672 - 1.21.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 362.0
TLS2_k127_5189543_10 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000001928 82.0
TLS2_k127_5189543_11 Prokaryotic N-terminal methylation motif - - - 0.000000000001177 74.0
TLS2_k127_5189543_12 Antibiotic biosynthesis monooxygenase - - - 0.000001989 54.0
TLS2_k127_5189543_13 transposase activity - - - 0.0001071 44.0
TLS2_k127_5189543_2 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 298.0
TLS2_k127_5189543_3 Glycine sarcosine betaine reductase K10671 - 1.21.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000004171 265.0
TLS2_k127_5189543_4 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000889 179.0
TLS2_k127_5189543_5 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000002796 170.0
TLS2_k127_5189543_6 PFAM amidohydrolase K07045 - - 0.000000000000000000000000000000000000003533 159.0
TLS2_k127_5189543_7 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000637 124.0
TLS2_k127_5189543_8 KR domain - - - 0.0000000000000000000000000007918 122.0
TLS2_k127_5189543_9 Selenoprotein B, glycine betaine sarcosine D-proline reductase family K10672 - 1.21.4.2 0.00000000000000002782 83.0
TLS2_k127_5197408_0 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 392.0
TLS2_k127_5197408_1 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000005059 151.0
TLS2_k127_5197408_2 PFAM NAD dependent epimerase dehydratase family K07071 - - 0.000000000000000000000000000000003408 133.0
TLS2_k127_5206319_0 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004395 445.0
TLS2_k127_5206319_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 421.0
TLS2_k127_5206319_10 4Fe-4S dicluster domain K00124 - - 0.00000000000000000000000000000000000000006227 160.0
TLS2_k127_5206319_11 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000003664 162.0
TLS2_k127_5206319_12 23S rRNA-intervening sequence protein - - - 0.00000000000000000000000000000000000001304 148.0
TLS2_k127_5206319_13 Could be involved in septation K06412 - - 0.000000000000000000000000000000000000383 142.0
TLS2_k127_5206319_14 Ribosomal protein L9, N-terminal domain K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000001629 143.0
TLS2_k127_5206319_15 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000001399 141.0
TLS2_k127_5206319_16 Predicted membrane protein (DUF2232) - - - 0.0000000000000000000000001943 117.0
TLS2_k127_5206319_17 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000573 108.0
TLS2_k127_5206319_18 Class ii aldolase K01628 - 4.1.2.17 0.00000000000000000000002171 109.0
TLS2_k127_5206319_19 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000004985 94.0
TLS2_k127_5206319_2 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 368.0
TLS2_k127_5206319_20 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.0000000000001404 82.0
TLS2_k127_5206319_21 Psort location Cytoplasmic, score 8.87 K02051 - - 0.000000000007113 76.0
TLS2_k127_5206319_3 aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 359.0
TLS2_k127_5206319_4 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000007839 266.0
TLS2_k127_5206319_5 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000008355 243.0
TLS2_k127_5206319_6 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000005411 214.0
TLS2_k127_5206319_7 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000003405 210.0
TLS2_k127_5206319_8 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000000000003387 190.0
TLS2_k127_5206319_9 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000003605 178.0
TLS2_k127_5219416_0 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 4.467e-224 719.0
TLS2_k127_5219416_1 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 9.99e-214 679.0
TLS2_k127_5219416_10 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005418 413.0
TLS2_k127_5219416_11 GMC oxidoreductase K06151 - 1.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 395.0
TLS2_k127_5219416_12 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000316 278.0
TLS2_k127_5219416_13 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004723 276.0
TLS2_k127_5219416_14 COG1335 Amidases related to nicotinamidase K09020 - 3.5.1.110 0.0000000000000000000000000000000000000000000000000000000000000000002051 238.0
TLS2_k127_5219416_15 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000233 228.0
TLS2_k127_5219416_16 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000001217 154.0
TLS2_k127_5219416_17 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000006782 114.0
TLS2_k127_5219416_18 Gluconate 2-dehydrogenase subunit 3 K06152 - 1.1.99.3 0.0000000000000000000000129 108.0
TLS2_k127_5219416_19 PFAM AzlC - - - 0.00000000000000000000008099 109.0
TLS2_k127_5219416_2 pyruvate K00627,K01571,K01960,K20140 - 2.3.1.12,4.1.1.3,6.4.1.1,6.4.1.7 6.263e-212 668.0
TLS2_k127_5219416_20 Uncharacterised MFS-type transporter YbfB K05819 - - 0.0000000000000000008502 99.0
TLS2_k127_5219416_21 ABC-type nitrate sulfonate bicarbonate transport - - - 0.00003044 55.0
TLS2_k127_5219416_22 - - - - 0.0001843 46.0
TLS2_k127_5219416_3 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 1.521e-197 632.0
TLS2_k127_5219416_4 asparagine synthase (Glutamine-hydrolyzing K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 544.0
TLS2_k127_5219416_5 MOFRL family K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004082 524.0
TLS2_k127_5219416_6 transferase activity, transferring glycosyl groups K13693,K21349 - 2.4.1.266,2.4.1.268 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006616 520.0
TLS2_k127_5219416_7 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 442.0
TLS2_k127_5219416_8 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 445.0
TLS2_k127_5219416_9 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 402.0
TLS2_k127_5255242_0 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000968 517.0
TLS2_k127_5255242_1 Adenylosuccinate lyase C-terminus K01756,K01857 - 4.3.2.2,5.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 419.0
TLS2_k127_5255242_10 Ndr family K01055,K14727 - 3.1.1.24,4.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007391 271.0
TLS2_k127_5255242_11 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000003055 275.0
TLS2_k127_5255242_12 S-(hydroxymethyl)glutathione dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004811 267.0
TLS2_k127_5255242_13 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003974 269.0
TLS2_k127_5255242_14 acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000001894 226.0
TLS2_k127_5255242_15 protocatechuate 3,4-dioxygenase activity K00448 - 1.13.11.3 0.000000000000000000000000000000000000000000000000000000000001443 216.0
TLS2_k127_5255242_16 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000001992 198.0
TLS2_k127_5255242_17 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000002068 187.0
TLS2_k127_5255242_18 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.0000000000000000000000000000000000000000007262 170.0
TLS2_k127_5255242_19 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.000000000000000000000000000000000000000007585 158.0
TLS2_k127_5255242_2 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain K03413 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003303 383.0
TLS2_k127_5255242_20 DsbA oxidoreductase - - - 0.00000000000000000000000000000000002351 141.0
TLS2_k127_5255242_21 Pfam Amidohydrolase K07045 - - 0.000000000000000000000000000003441 133.0
TLS2_k127_5255242_22 PFAM isochorismatase hydrolase - - - 0.00000000000000000000005338 105.0
TLS2_k127_5255242_23 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.00000000000000000002471 103.0
TLS2_k127_5255242_24 Transporter - - - 0.00000000000000000209 95.0
TLS2_k127_5255242_25 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.000000000000000005951 96.0
TLS2_k127_5255242_26 NMT1-like family K02051 - - 0.0000000000000000803 92.0
TLS2_k127_5255242_27 Protein of unknown function, DUF488 - - - 0.00000000000003847 73.0
TLS2_k127_5255242_28 Cupin domain - - - 0.00000000000005152 77.0
TLS2_k127_5255242_29 transporter K02012 - - 0.0000000000003552 81.0
TLS2_k127_5255242_3 Coenzyme A transferase K01039 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006235 372.0
TLS2_k127_5255242_30 NMT1/THI5 like K18278 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016853,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0070283,GO:0070284,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.000000003498 68.0
TLS2_k127_5255242_4 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 353.0
TLS2_k127_5255242_5 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009627 333.0
TLS2_k127_5255242_6 protocatechuate 3,4-dioxygenase, beta subunit' K00449 - 1.13.11.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 312.0
TLS2_k127_5255242_7 protein related to plant photosystem II stability assembly factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 302.0
TLS2_k127_5255242_8 Coenzyme A transferase K01040 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 290.0
TLS2_k127_5255242_9 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009102 290.0
TLS2_k127_5324857_0 Methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 389.0
TLS2_k127_5324857_1 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007932 366.0
TLS2_k127_5324857_10 PFAM NMT1 THI5 like domain protein K02051 - - 0.0000000000000775 83.0
TLS2_k127_5324857_11 NMT1-like family - - - 0.000000000007667 77.0
TLS2_k127_5324857_12 Major Facilitator Superfamily - - - 0.000000000007962 67.0
TLS2_k127_5324857_13 Luciferase-like monooxygenase - - - 0.000000007383 63.0
TLS2_k127_5324857_14 Glyoxalase-like domain - - - 0.000003844 56.0
TLS2_k127_5324857_2 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 307.0
TLS2_k127_5324857_3 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006821 289.0
TLS2_k127_5324857_4 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000001475 222.0
TLS2_k127_5324857_5 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000001286 206.0
TLS2_k127_5324857_6 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000000000000002812 191.0
TLS2_k127_5324857_7 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - 0.00000000000000000000000000000000000000000000002782 186.0
TLS2_k127_5324857_8 Asp/Glu/Hydantoin racemase K01799 - 5.2.1.1 0.0000000000000000000000000000000000000007963 156.0
TLS2_k127_5324857_9 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000001204 134.0
TLS2_k127_5346470_0 Uncharacterized protein conserved in bacteria (DUF2309) K09822 - - 0.0 1158.0
TLS2_k127_5346470_1 PFAM amidohydrolase - - - 6.947e-306 950.0
TLS2_k127_5346470_10 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 457.0
TLS2_k127_5346470_11 carbohydrate transport K02027,K10236 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 421.0
TLS2_k127_5346470_12 Quinone oxidoreductase, YhdH YhfP family K19745 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 400.0
TLS2_k127_5346470_13 PFAM amidohydrolase K01464,K01465 - 3.5.2.2,3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 396.0
TLS2_k127_5346470_14 ABC transporter K10112,K11072,K17324 - 3.6.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 370.0
TLS2_k127_5346470_15 Conserved carboxylase domain K01571 - 4.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007564 363.0
TLS2_k127_5346470_16 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 363.0
TLS2_k127_5346470_17 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 361.0
TLS2_k127_5346470_18 Amidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 356.0
TLS2_k127_5346470_19 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 366.0
TLS2_k127_5346470_2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01576,K01652 - 2.2.1.6,4.1.1.7 2.319e-221 702.0
TLS2_k127_5346470_20 transmembrane transport K02025,K10237,K15771 GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 336.0
TLS2_k127_5346470_21 TIGRFAM DNA-3-methyladenine glycosylase I K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 308.0
TLS2_k127_5346470_22 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 316.0
TLS2_k127_5346470_23 glycerophosphodiester transmembrane transport K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 306.0
TLS2_k127_5346470_24 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 293.0
TLS2_k127_5346470_25 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006521 293.0
TLS2_k127_5346470_26 isochorismatase hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 292.0
TLS2_k127_5346470_27 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000167 267.0
TLS2_k127_5346470_28 iron ion homeostasis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000679 280.0
TLS2_k127_5346470_29 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007825 253.0
TLS2_k127_5346470_3 2-methylcitrate dehydratase K01720 - 4.2.1.79 1.127e-219 690.0
TLS2_k127_5346470_30 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000214 248.0
TLS2_k127_5346470_31 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781 - 5.1.2.2 0.000000000000000000000000000000000000000000000000000000000000006367 233.0
TLS2_k127_5346470_32 Kelch motif - - - 0.0000000000000000000000000000000000000000000000000000000000008371 222.0
TLS2_k127_5346470_33 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000007039 207.0
TLS2_k127_5346470_34 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000003224 217.0
TLS2_k127_5346470_35 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000003575 219.0
TLS2_k127_5346470_36 mannosylglycerate metabolic process K05947,K07026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897 2.4.1.217,3.1.3.70 0.000000000000000000000000000000000000000000000000000000005721 209.0
TLS2_k127_5346470_37 abc-type fe3 -hydroxamate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000576 192.0
TLS2_k127_5346470_38 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000005104 201.0
TLS2_k127_5346470_4 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 595.0
TLS2_k127_5346470_40 PFAM Histidine triad (HIT) protein - - - 0.0000000000000000000000000000000000000000002696 168.0
TLS2_k127_5346470_41 Rhomboid family - - - 0.000000000000000000000000000000000000000000368 169.0
TLS2_k127_5346470_42 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000000000000000295 151.0
TLS2_k127_5346470_43 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.000000000000000000000000000000000000003429 156.0
TLS2_k127_5346470_44 TIR domain - - - 0.00000000000000000000000000000000002616 147.0
TLS2_k127_5346470_45 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000001614 137.0
TLS2_k127_5346470_46 Protein of unknown function (DUF2459) - - - 0.00000000000000000000000000002262 125.0
TLS2_k127_5346470_47 protein conserved in bacteria - - - 0.00000000000000000000000000002871 130.0
TLS2_k127_5346470_48 Stage II sporulation protein M K06384 - - 0.000000000000000000000000008776 117.0
TLS2_k127_5346470_49 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000002146 118.0
TLS2_k127_5346470_5 NADH-quinone oxidoreductase K00341,K05577 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 610.0
TLS2_k127_5346470_51 protein conserved in bacteria - - - 0.000000000000000000000000174 119.0
TLS2_k127_5346470_52 Peptidase M50 K16922 - - 0.00000000000000000000000388 116.0
TLS2_k127_5346470_53 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000688 111.0
TLS2_k127_5346470_54 Antibiotic biosynthesis monooxygenase K09932 - - 0.0000000000000000000003567 99.0
TLS2_k127_5346470_55 Protein of unknown function (DUF1003) - - - 0.000000000000000000002177 101.0
TLS2_k127_5346470_56 NMT1-like family K02051 - - 0.00000000000000000006838 102.0
TLS2_k127_5346470_57 SdpI/YhfL protein family - - - 0.0000000000000000001108 95.0
TLS2_k127_5346470_58 Class II aldolase adducin family protein K01628 - 4.1.2.17 0.0000000000000000001176 98.0
TLS2_k127_5346470_59 THIoesterase K18700 - 3.1.2.29 0.0000000000000000001456 96.0
TLS2_k127_5346470_6 Citrate synthase, C-terminal domain K01659 - 2.3.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 519.0
TLS2_k127_5346470_60 Antibiotic biosynthesis monooxygenase K09932 - - 0.000000000000000008168 96.0
TLS2_k127_5346470_61 Tetratricopeptide repeat - - - 0.000000000000000008673 96.0
TLS2_k127_5346470_62 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.00000000000000336 77.0
TLS2_k127_5346470_63 KR domain K00059 - 1.1.1.100 0.00000000000007685 77.0
TLS2_k127_5346470_64 PFAM Excinuclease ABC C subunit domain protein K07461 - - 0.000000000001598 69.0
TLS2_k127_5346470_65 peptidoglycan-binding domain-containing protein - - - 0.000000000003781 76.0
TLS2_k127_5346470_66 Sigma-54 interaction domain K15836 - - 0.00000000002654 68.0
TLS2_k127_5346470_67 DoxX K15977 - - 0.0000000000636 74.0
TLS2_k127_5346470_68 KR domain K00059 - 1.1.1.100 0.0000000000967 65.0
TLS2_k127_5346470_69 NMT1-like family K02051 - - 0.000000003927 68.0
TLS2_k127_5346470_7 PFAM Glycosyl transferase family 2 K21349 - 2.4.1.268 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 521.0
TLS2_k127_5346470_70 ABC transporter K15553 GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0044237 - 0.000000007753 67.0
TLS2_k127_5346470_71 cysteine dioxygenase type I - - - 0.000001662 57.0
TLS2_k127_5346470_72 YCII-related domain K09780 - - 0.000001989 54.0
TLS2_k127_5346470_73 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000003435 58.0
TLS2_k127_5346470_74 Enoyl-(Acyl carrier protein) reductase - - - 0.000003911 50.0
TLS2_k127_5346470_76 Enoyl-(Acyl carrier protein) reductase - - - 0.00073 44.0
TLS2_k127_5346470_77 Cupin 2, conserved barrel domain protein - - - 0.0007529 49.0
TLS2_k127_5346470_78 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0008041 47.0
TLS2_k127_5346470_8 transferase activity, transferring glycosyl groups K09118,K13693,K21349 - 2.4.1.266,2.4.1.268 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003985 528.0
TLS2_k127_5346470_9 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008774 495.0
TLS2_k127_5352300_0 Domain of unknown function (DUF4105) - - - 3.826e-203 651.0
TLS2_k127_5352300_1 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 484.0
TLS2_k127_5352300_10 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000003703 132.0
TLS2_k127_5352300_11 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K02439,K07390 GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016740,GO:0016782,GO:0016783,GO:0044424,GO:0044464 2.8.1.1 0.0000000000000000000000000006437 117.0
TLS2_k127_5352300_12 Belongs to the ompA family K03286 - - 0.00000000000000000000000001171 119.0
TLS2_k127_5352300_13 - - - - 0.00000000000000000000001339 106.0
TLS2_k127_5352300_14 Domain of unknown function (DUF4147) K11529 - 2.7.1.165 0.00000000000000000007179 91.0
TLS2_k127_5352300_15 TPM domain K06872 - - 0.000000000000006903 85.0
TLS2_k127_5352300_16 PFAM major facilitator superfamily MFS_1 - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000003649 78.0
TLS2_k127_5352300_2 fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 381.0
TLS2_k127_5352300_3 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004931 358.0
TLS2_k127_5352300_4 PFAM peptidase M48 Ste24p - - - 0.000000000000000000000000000000000000000000000000000000000000000000005289 242.0
TLS2_k127_5352300_5 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000008622 207.0
TLS2_k127_5352300_6 lytic transglycosylase activity - - - 0.00000000000000000000000000000000000000000000001669 175.0
TLS2_k127_5352300_7 Cupin 2, conserved barrel domain protein K00452,K11312,K16953 - 1.13.11.6,4.4.1.3 0.00000000000000000000000000000000000000000000007933 174.0
TLS2_k127_5352300_8 Protein of unknown function (DUF3015) - - - 0.0000000000000000000000000000000000000001956 156.0
TLS2_k127_5352300_9 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000000000008075 157.0
TLS2_k127_5377868_0 Pfam:HxxPF_rpt - - - 0.0 1670.0
TLS2_k127_5377868_1 Amino acid adenylation domain - - - 0.0 1133.0
TLS2_k127_5377868_10 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.00000000000000000000000000000000000000000000000000000001706 202.0
TLS2_k127_5377868_11 Pfam:Methyltransf_26 K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000286 159.0
TLS2_k127_5377868_12 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000000007188 119.0
TLS2_k127_5377868_13 Alpha beta hydrolase - - - 0.00001965 57.0
TLS2_k127_5377868_2 Adenylate and Guanylate cyclase catalytic domain - - - 1.938e-254 818.0
TLS2_k127_5377868_3 Required for chromosome condensation and partitioning K03529 - - 1.161e-224 739.0
TLS2_k127_5377868_4 Sigma-54 interaction domain K02584,K07713,K15836,K21009 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007205 464.0
TLS2_k127_5377868_5 Thioesterase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 460.0
TLS2_k127_5377868_6 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 434.0
TLS2_k127_5377868_7 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 347.0
TLS2_k127_5377868_8 PFAM Alcohol dehydrogenase, zinc-binding K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 301.0
TLS2_k127_5377868_9 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004542 269.0
TLS2_k127_5413569_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03694,K03695 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0 1160.0
TLS2_k127_5413569_1 Helix-hairpin-helix containing domain K03581 - 3.1.11.5 1.782e-214 689.0
TLS2_k127_5413569_10 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 365.0
TLS2_k127_5413569_11 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 352.0
TLS2_k127_5413569_12 Succinyl-CoA ligase like flavodoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008808 361.0
TLS2_k127_5413569_13 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 338.0
TLS2_k127_5413569_14 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 323.0
TLS2_k127_5413569_15 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008661 307.0
TLS2_k127_5413569_16 PFAM amidohydrolase 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 291.0
TLS2_k127_5413569_17 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008208 271.0
TLS2_k127_5413569_18 IMS family HHH motif K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000001681 276.0
TLS2_k127_5413569_19 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004973 279.0
TLS2_k127_5413569_2 fumarate reductase succinate dehydrogenase flavoprotein domain protein K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008158 567.0
TLS2_k127_5413569_20 MmgE/PrpD family - - - 0.0000000000000000000000000000000000000000000000000000000000000006729 236.0
TLS2_k127_5413569_21 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000001417 204.0
TLS2_k127_5413569_22 S1/P1 Nuclease - - - 0.0000000000000000000000000000000000000000000000000002897 195.0
TLS2_k127_5413569_23 PFAM luciferase-like - - - 0.0000000000000000000000000000000000000000000000000004657 197.0
TLS2_k127_5413569_24 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000001054 173.0
TLS2_k127_5413569_25 acetyltransferase - - - 0.000000000000000000000000000000000000000000002593 168.0
TLS2_k127_5413569_26 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000006935 173.0
TLS2_k127_5413569_27 membrane - - - 0.00000000000000000000000000000000000000000001394 165.0
TLS2_k127_5413569_28 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000002556 160.0
TLS2_k127_5413569_29 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000003765 172.0
TLS2_k127_5413569_3 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K01719,K13542 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,4.1.1.37,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 458.0
TLS2_k127_5413569_30 Asp/Glu/Hydantoin racemase K01799 - 5.2.1.1 0.000000000000000000000000000000000000000007303 164.0
TLS2_k127_5413569_31 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000799 145.0
TLS2_k127_5413569_32 Circadian clock protein KaiC K08482 - - 0.0000000000000000000000000000000000002635 150.0
TLS2_k127_5413569_33 Circadian clock protein KaiC K08482 - - 0.0000000000000000000000000000000441 135.0
TLS2_k127_5413569_34 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000005079 119.0
TLS2_k127_5413569_35 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000006753 120.0
TLS2_k127_5413569_36 Glyoxalase-like domain - - - 0.00000000000000000000001263 104.0
TLS2_k127_5413569_37 Maleate cis-trans isomerase K01799 - 5.2.1.1 0.00000000000000001743 91.0
TLS2_k127_5413569_38 Major facilitator superfamily - - - 0.00000000000000005009 87.0
TLS2_k127_5413569_39 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.0000000000000527 81.0
TLS2_k127_5413569_4 protoporphyrinogen oxidase activity K00231,K14266 - 1.14.19.9,1.3.3.15,1.3.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 451.0
TLS2_k127_5413569_40 AAA domain - - - 0.00000000001861 68.0
TLS2_k127_5413569_41 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.00000000003215 76.0
TLS2_k127_5413569_43 Glyoxalase-like domain - - - 0.0000000004297 70.0
TLS2_k127_5413569_44 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000006863 70.0
TLS2_k127_5413569_45 lactoylglutathione lyase activity K11210 - - 0.00000003453 64.0
TLS2_k127_5413569_46 pyridoxamine 5-phosphate - - - 0.000000147 58.0
TLS2_k127_5413569_47 - - - - 0.00001132 56.0
TLS2_k127_5413569_5 Methionine synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000055 422.0
TLS2_k127_5413569_6 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 406.0
TLS2_k127_5413569_7 MFS_1 like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 404.0
TLS2_k127_5413569_8 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 376.0
TLS2_k127_5413569_9 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 374.0
TLS2_k127_5413612_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 3e-323 1000.0
TLS2_k127_5413612_1 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000003523 146.0
TLS2_k127_5413612_2 Transposase IS200 like - - - 0.000008409 48.0
TLS2_k127_5420132_0 4-hydroxyphenylacetate 3-hydroxylase C terminal K00483 - 1.14.14.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006837 471.0
TLS2_k127_5420132_1 Amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000001371 235.0
TLS2_k127_5420132_2 Antibiotic biosynthesis monooxygenase - - - 0.0004795 46.0
TLS2_k127_5433852_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1171.0
TLS2_k127_5433852_1 histidine kinase, HAMP K13598 - 2.7.13.3 6.087e-211 678.0
TLS2_k127_5433852_10 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.0000000000000000000000000000000000000005017 155.0
TLS2_k127_5433852_11 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000817 156.0
TLS2_k127_5433852_12 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000000005032 138.0
TLS2_k127_5433852_13 Protein of unknown function (DUF2905) - - - 0.0000000000000000001218 92.0
TLS2_k127_5433852_14 conserved protein (DUF2203) - - - 0.00000000000000003192 87.0
TLS2_k127_5433852_15 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0008326 44.0
TLS2_k127_5433852_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007491 493.0
TLS2_k127_5433852_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 457.0
TLS2_k127_5433852_4 UDP-3-O-acyl N-acetylglycosamine deacetylase K02535,K13599 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 387.0
TLS2_k127_5433852_5 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 321.0
TLS2_k127_5433852_6 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005353 246.0
TLS2_k127_5433852_7 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.00000000000000000000000000000000000000000000000005305 184.0
TLS2_k127_5433852_8 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000002477 182.0
TLS2_k127_5433852_9 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000003417 157.0
TLS2_k127_5445616_0 KaiC K08482 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003557 576.0
TLS2_k127_5445616_1 PFAM amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 319.0
TLS2_k127_5445616_10 NMT1-like family K02051 - - 0.0000000006219 70.0
TLS2_k127_5445616_11 protein conserved in bacteria - - - 0.0000000008166 61.0
TLS2_k127_5445616_12 Histidine kinase - - - 0.00007521 51.0
TLS2_k127_5445616_13 4,5-dihydroxyphthalate decarboxylase - - - 0.0009153 44.0
TLS2_k127_5445616_2 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000003894 189.0
TLS2_k127_5445616_3 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000001533 175.0
TLS2_k127_5445616_4 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000005593 164.0
TLS2_k127_5445616_5 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000004051 139.0
TLS2_k127_5445616_6 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000004636 134.0
TLS2_k127_5445616_7 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00000000000003389 84.0
TLS2_k127_5445616_8 KaiB K08481 - - 0.0000000000001004 77.0
TLS2_k127_5445616_9 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000826 70.0
TLS2_k127_5497039_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07306,K08352 - 1.8.5.3,1.8.5.5 4.579e-228 730.0
TLS2_k127_5497039_1 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002968 627.0
TLS2_k127_5497039_10 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002146 282.0
TLS2_k127_5497039_11 Transmembrane secretion effector K08225 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003445 285.0
TLS2_k127_5497039_12 positive regulation of transcription, DNA-templated K06206 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0044238,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004377 271.0
TLS2_k127_5497039_13 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000006618 256.0
TLS2_k127_5497039_14 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000001111 240.0
TLS2_k127_5497039_15 Isochorismatase family K08281 - 3.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000001032 226.0
TLS2_k127_5497039_16 PFAM Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000001478 216.0
TLS2_k127_5497039_17 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000002259 207.0
TLS2_k127_5497039_18 Ribosomal RNA adenine dimethylases K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.000000000000000000000000000000000000000000000000000000002734 209.0
TLS2_k127_5497039_19 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000002733 207.0
TLS2_k127_5497039_2 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 534.0
TLS2_k127_5497039_20 Transcriptional regulator, CarD family K07736 - - 0.00000000000000000000000000000000000000000000000000001359 193.0
TLS2_k127_5497039_21 Haloacid dehalogenase-like hydrolase K07025 - - 0.00000000000000000000000000000000000000000000000001879 187.0
TLS2_k127_5497039_22 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.00000000000000000000000000000000000000000000000489 181.0
TLS2_k127_5497039_23 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.0000000000000000000000000000000000000000000005785 172.0
TLS2_k127_5497039_24 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000005925 176.0
TLS2_k127_5497039_25 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000005964 163.0
TLS2_k127_5497039_26 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.00000000000000000000000000000000000000004227 154.0
TLS2_k127_5497039_27 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000357 156.0
TLS2_k127_5497039_28 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.0000000000000000000000000000000008711 136.0
TLS2_k127_5497039_29 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.00000000000000000000000000000001708 139.0
TLS2_k127_5497039_3 Belongs to the Glu Leu Phe Val dehydrogenases family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 521.0
TLS2_k127_5497039_30 Transposase IS200 like - - - 0.000000000000000000000000000003628 121.0
TLS2_k127_5497039_32 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000001646 126.0
TLS2_k127_5497039_33 Domain of unknown function (DUF1844) - - - 0.000000000000000000000000006919 117.0
TLS2_k127_5497039_34 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.0000000000000000000000004825 106.0
TLS2_k127_5497039_35 - - - - 0.000000000000000000000001417 104.0
TLS2_k127_5497039_36 Histidine kinase K07681,K11617 - 2.7.13.3 0.000000000000000000000009504 109.0
TLS2_k127_5497039_37 Rieske 2Fe-2S - - - 0.00000000000000000000005153 105.0
TLS2_k127_5497039_38 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.00000000000000003058 89.0
TLS2_k127_5497039_39 - - - - 0.0000598 46.0
TLS2_k127_5497039_4 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 475.0
TLS2_k127_5497039_40 NMT1-like family - - - 0.00009277 45.0
TLS2_k127_5497039_5 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009417 404.0
TLS2_k127_5497039_6 Glycoprotease family K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007988 365.0
TLS2_k127_5497039_7 Dihydrodipicolinate synthetase family K14585 - 4.1.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 334.0
TLS2_k127_5497039_8 COG1715 Restriction endonuclease K07448 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 315.0
TLS2_k127_5497039_9 PFAM asparagine synthase K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007684 291.0
TLS2_k127_5577918_0 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 401.0
TLS2_k127_5577918_1 PFAM Uncharacterised ACR, YagE family COG1723 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 365.0
TLS2_k127_5577918_10 Putative nucleotidyltransferase substrate binding domain - - - 0.000000000000000000000006762 113.0
TLS2_k127_5577918_11 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000008392 118.0
TLS2_k127_5577918_12 Universal stress protein - - - 0.000000000000000000000107 104.0
TLS2_k127_5577918_13 DNA primase activity - - - 0.00000000000000000001637 104.0
TLS2_k127_5577918_14 Rubrerythrin - - - 0.0002592 49.0
TLS2_k127_5577918_15 Putative regulatory protein - - - 0.0003196 46.0
TLS2_k127_5577918_2 Domain of unknown function (DUF4010) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 347.0
TLS2_k127_5577918_3 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 319.0
TLS2_k127_5577918_4 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003108 308.0
TLS2_k127_5577918_5 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007851 274.0
TLS2_k127_5577918_6 AMP binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005889 264.0
TLS2_k127_5577918_7 response regulator K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000003099 237.0
TLS2_k127_5577918_8 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000000000000000000000000000000000000000000000000000000821 227.0
TLS2_k127_5577918_9 CBS domain containing protein K04767 - - 0.000000000000000000000000002345 119.0
TLS2_k127_5644480_0 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 1.31e-198 629.0
TLS2_k127_5644480_1 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 373.0
TLS2_k127_5644480_2 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000003706 194.0
TLS2_k127_5644480_3 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000002479 139.0
TLS2_k127_5644480_4 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.000001116 53.0
TLS2_k127_5666876_0 His Kinase A (phospho-acceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 308.0
TLS2_k127_5666876_1 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000003413 188.0
TLS2_k127_5666876_2 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000006598 126.0
TLS2_k127_5666876_3 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000005828 128.0
TLS2_k127_5666876_4 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.00000002572 65.0
TLS2_k127_5666876_5 4,5-dihydroxyphthalate decarboxylase K04102 - 4.1.1.55 0.00000003734 64.0
TLS2_k127_5666876_6 Endoribonuclease L-PSP - - - 0.00002729 53.0
TLS2_k127_5681828_0 Transketolase, C-terminal domain K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007791 529.0
TLS2_k127_5681828_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005795 478.0
TLS2_k127_5681828_2 Catalytic domain of components of various dehydrogenase complexes K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 410.0
TLS2_k127_5681828_3 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000000000171 156.0
TLS2_k127_5681828_4 Phosphopantetheine attachment site - - - 0.00000000000000000002752 92.0
TLS2_k127_5689257_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 448.0
TLS2_k127_5689257_1 PFAM ATPase associated with various cellular activities, AAA_5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 392.0
TLS2_k127_5689257_10 NUDIX hydrolase - - - 0.00000000000000000000000000000000006515 143.0
TLS2_k127_5689257_11 LVIVD repeat - - - 0.00000000000000005269 81.0
TLS2_k127_5689257_12 Iron-containing redox enzyme K06137 - 1.3.3.11 0.000000000000000939 86.0
TLS2_k127_5689257_14 Elements of external origin - - - 0.0000001116 53.0
TLS2_k127_5689257_15 protein trimerization - - - 0.000001976 58.0
TLS2_k127_5689257_2 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 361.0
TLS2_k127_5689257_3 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 326.0
TLS2_k127_5689257_4 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003007 273.0
TLS2_k127_5689257_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000007817 250.0
TLS2_k127_5689257_6 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000000000000000000000001033 231.0
TLS2_k127_5689257_7 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000002338 229.0
TLS2_k127_5689257_8 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000001829 164.0
TLS2_k127_5689257_9 Transport and Golgi organisation 2 - - - 0.00000000000000000000000000000000001626 145.0
TLS2_k127_5703558_0 CoA-binding domain protein - - - 0.0 1048.0
TLS2_k127_5703558_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 1.84e-271 845.0
TLS2_k127_5703558_2 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate K07749 - 2.8.3.16 7.225e-199 626.0
TLS2_k127_5703558_3 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 417.0
TLS2_k127_5703558_4 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00169,K19070 GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 406.0
TLS2_k127_5705259_0 Tripartite tricarboxylate transporter TctA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008291 263.0
TLS2_k127_5705259_1 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000004135 242.0
TLS2_k127_5705259_2 - - - - 0.0000000000000000000000000000000000003028 142.0
TLS2_k127_5705259_3 Cupin domain - - - 0.000285 48.0
TLS2_k127_5747827_0 DNA replication proofreading K02336,K06877,K07501 - 2.7.7.7 2.536e-268 846.0
TLS2_k127_5747827_1 PFAM Aldehyde dehydrogenase family K00128,K00135,K00146,K22187 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.39,1.2.1.79 3.706e-226 709.0
TLS2_k127_5747827_10 PFAM Nucleotidyl transferase K00971 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003248 292.0
TLS2_k127_5747827_11 tRNA methyltransferase complex GCD14 subunit N-term K07442 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009649 271.0
TLS2_k127_5747827_12 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000003868 269.0
TLS2_k127_5747827_13 PAC2 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000313 246.0
TLS2_k127_5747827_14 MlaA lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000000000003246 240.0
TLS2_k127_5747827_15 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.00000000000000000000000000000000000000000000000008252 192.0
TLS2_k127_5747827_16 photosynthesis - - - 0.00000000000000000000000000000000000000000003139 166.0
TLS2_k127_5747827_17 Domain of unknown function (DUF4416) - - - 0.00000000000000000000000000000004597 131.0
TLS2_k127_5747827_18 epimerase dehydratase - - - 0.000000000000000000000000001245 124.0
TLS2_k127_5747827_19 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.00000000000000000008501 94.0
TLS2_k127_5747827_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 535.0
TLS2_k127_5747827_20 TIGRFAM ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.00000000004497 74.0
TLS2_k127_5747827_21 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.0000001592 61.0
TLS2_k127_5747827_22 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00007302 46.0
TLS2_k127_5747827_23 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0008554 47.0
TLS2_k127_5747827_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 449.0
TLS2_k127_5747827_4 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 372.0
TLS2_k127_5747827_5 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 348.0
TLS2_k127_5747827_6 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 347.0
TLS2_k127_5747827_7 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 320.0
TLS2_k127_5747827_8 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 315.0
TLS2_k127_5747827_9 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 297.0
TLS2_k127_5756127_0 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001076 242.0
TLS2_k127_5756127_1 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.00000000000000009155 89.0
TLS2_k127_5756127_2 PFAM peptidase S11, D-alanyl-D-alanine carboxypeptidase K07258 - 3.4.16.4 0.000000000000009593 75.0
TLS2_k127_5756127_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000006031 66.0
TLS2_k127_5756127_4 FR47-like protein - - - 0.00002064 51.0
TLS2_k127_5781008_0 NAD(P)-binding Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 617.0
TLS2_k127_5781008_1 Binding-protein-dependent transport system inner membrane component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 437.0
TLS2_k127_5781008_10 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000007338 212.0
TLS2_k127_5781008_11 reverse transcriptase - - - 0.000000000000000000000000000000000000000000000004981 175.0
TLS2_k127_5781008_12 Carboxylesterase family - - - 0.00000000000000000000000000000000000000000000006222 175.0
TLS2_k127_5781008_13 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000002308 162.0
TLS2_k127_5781008_14 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000001573 152.0
TLS2_k127_5781008_15 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000001937 153.0
TLS2_k127_5781008_16 NUDIX domain - - - 0.00000000000000000000000000000001656 139.0
TLS2_k127_5781008_17 enoyl-CoA hydratase K01715 - 4.2.1.17 0.000000000000000000000000000000267 133.0
TLS2_k127_5781008_18 Endoribonuclease L-PSP - - - 0.000000000000000003633 89.0
TLS2_k127_5781008_19 - - - - 0.000000000000007388 81.0
TLS2_k127_5781008_2 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 405.0
TLS2_k127_5781008_20 decarboxylase K01607 - 4.1.1.44 0.00000000000002893 80.0
TLS2_k127_5781008_21 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00000000003486 75.0
TLS2_k127_5781008_22 SpoVT / AbrB like domain K07172 - - 0.00000001572 58.0
TLS2_k127_5781008_24 Lysozyme inhibitor LprI - - - 0.000158 44.0
TLS2_k127_5781008_3 Reverse transcriptase (RNA-dependent DNA polymerase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 376.0
TLS2_k127_5781008_4 Peptidase, M16 K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003326 318.0
TLS2_k127_5781008_5 Peptidase M16 inactive domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000891 258.0
TLS2_k127_5781008_6 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000003244 233.0
TLS2_k127_5781008_7 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000004168 250.0
TLS2_k127_5781008_8 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000003935 217.0
TLS2_k127_5781008_9 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000504 214.0
TLS2_k127_5799487_0 Tripartite tricarboxylate transporter TctA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 470.0
TLS2_k127_5799487_1 Pfam Cupin K00450,K11948 - 1.13.11.38,1.13.11.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004976 321.0
TLS2_k127_5799487_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000634 212.0
TLS2_k127_5799487_3 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000000000000000000001567 122.0
TLS2_k127_5799487_5 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.0000000002838 66.0
TLS2_k127_5808781_0 Class II aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 356.0
TLS2_k127_5808781_1 PFAM Phage derived protein Gp49-like (DUF891) - - - 0.000000000000000000000000000000000002707 140.0
TLS2_k127_5808781_2 Helix-turn-helix domain - - - 0.00000000000000000000000000000003096 128.0
TLS2_k127_5808781_3 Plasmid maintenance system killer K07334 - - 0.0000000000000000000000000000004935 123.0
TLS2_k127_5808781_4 Helix-turn-helix XRE-family like proteins K21498 - - 0.000000000000000000000000005111 113.0
TLS2_k127_5808781_5 - - - - 0.0000000000001232 73.0
TLS2_k127_5808781_6 Taurine catabolism dioxygenase TauD, TfdA family K03119,K22303 - 1.14.11.17 0.000000000001247 70.0
TLS2_k127_5808781_7 Class II aldolase - - - 0.00000001339 56.0
TLS2_k127_5819057_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001325 278.0
TLS2_k127_5819057_1 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002039 282.0
TLS2_k127_5819057_10 endonuclease exonuclease phosphatase - - - 0.0000000000000000000001191 107.0
TLS2_k127_5819057_11 PFAM Nitroreductase - - - 0.000000000000000003905 94.0
TLS2_k127_5819057_2 Binding-protein-dependent transport system inner membrane component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002911 280.0
TLS2_k127_5819057_3 Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000006332 254.0
TLS2_k127_5819057_4 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007577 256.0
TLS2_k127_5819057_5 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000003638 246.0
TLS2_k127_5819057_6 Nitronate monooxygenase K00459,K02371 - 1.13.12.16,1.3.1.9 0.00000000000000000000000000000000000000000000000000001405 201.0
TLS2_k127_5819057_7 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000845 166.0
TLS2_k127_5819057_8 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.000000000000000000000000007767 118.0
TLS2_k127_5819057_9 Glycine/sarcosine/betaine reductase component B subunits K10793 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0046992,GO:0050002,GO:0050485,GO:0055114 1.21.4.1 0.000000000000000000000001953 108.0
TLS2_k127_5824427_0 transmembrane transport K02035,K15580 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006869,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010876,GO:0015711,GO:0015718,GO:0015721,GO:0015833,GO:0015849,GO:0015850,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042939,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004813 578.0
TLS2_k127_5824427_1 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006105 551.0
TLS2_k127_5824427_2 Conserved carboxylase domain K01571 - 4.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 422.0
TLS2_k127_5824427_3 nitrogen compound transport K02033,K15581 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008757 362.0
TLS2_k127_5824427_4 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001562 285.0
TLS2_k127_5824427_5 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K15582,K16201 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000003268 257.0
TLS2_k127_5824427_6 PFAM Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000004278 227.0
TLS2_k127_5824427_7 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000004121 113.0
TLS2_k127_589367_0 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007768 423.0
TLS2_k127_5906331_0 Protein of unknown function (DUF1015) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 326.0
TLS2_k127_5906331_1 Belongs to the prokaryotic GSH synthase family K01920 GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 308.0
TLS2_k127_5906331_2 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000000004303 196.0
TLS2_k127_5906331_3 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000000000000000000000000001166 179.0
TLS2_k127_5906331_4 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000003639 178.0
TLS2_k127_5906331_5 RDD family - - - 0.00000000004949 73.0
TLS2_k127_5906331_6 - - - - 0.0000001066 53.0
TLS2_k127_5953995_0 Beta-eliminating lyase K01668 - 4.1.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 342.0
TLS2_k127_5953995_1 AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001717 276.0
TLS2_k127_5953995_10 PFAM NAD binding domain of 6-phosphogluconate dehydrogenase K00042 - 1.1.1.60 0.000000002195 64.0
TLS2_k127_5953995_11 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0001474 50.0
TLS2_k127_5953995_2 PFAM 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000001006 237.0
TLS2_k127_5953995_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000005883 198.0
TLS2_k127_5953995_4 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000003165 181.0
TLS2_k127_5953995_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000001334 177.0
TLS2_k127_5953995_6 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000002002 122.0
TLS2_k127_5953995_7 NUDIX domain - - - 0.0000000000000000000002334 107.0
TLS2_k127_5953995_8 Domain of unknown function (DUF1768) K09935 - - 0.000000000000000004464 91.0
TLS2_k127_5953995_9 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000002175 77.0
TLS2_k127_5967395_0 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007746 398.0
TLS2_k127_5967395_1 Belongs to the ABC transporter superfamily K10112 GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015399,GO:0015405,GO:0015430,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264,GO:1901505 - 0.00000000000000000000000000000000000000000000000000000000000002627 222.0
TLS2_k127_5967395_2 PFAM small multidrug resistance protein K11741 - - 0.000000000000000000000000000000000000000000001289 166.0
TLS2_k127_5967395_3 amidohydrolase K03392,K07045 - 4.1.1.45 0.000000000000000000000000000000000000000000001444 176.0
TLS2_k127_5967395_4 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000003339 155.0
TLS2_k127_5967395_5 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000013 133.0
TLS2_k127_5967395_6 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C K06137 - 1.3.3.11 0.0000000000000000000000004429 114.0
TLS2_k127_5967395_8 Redoxin - - - 0.0002532 48.0
TLS2_k127_5984614_0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.000000000000002064 80.0
TLS2_k127_5984614_1 ABC transporter, phosphonate, periplasmic substrate-binding protein K02051 - - 0.0000000007864 70.0
TLS2_k127_6038098_0 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 425.0
TLS2_k127_6038098_1 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 352.0
TLS2_k127_6038098_10 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000005566 252.0
TLS2_k127_6038098_11 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000001289 226.0
TLS2_k127_6038098_12 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000002567 217.0
TLS2_k127_6038098_13 Pfam:AmoA K07120 - - 0.000000000000000000000000000000000000000000000000000000000001546 223.0
TLS2_k127_6038098_14 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000008349 136.0
TLS2_k127_6038098_15 ACT domain - - - 0.000000000000000000000000000000001509 136.0
TLS2_k127_6038098_16 Type IV pilus biogenesis stability protein PilW - - - 0.00000000000000000000004119 108.0
TLS2_k127_6038098_17 glyoxalase bleomycin resistance protein dioxygenase K01759,K08234 - 4.4.1.5 0.00000000000000001667 87.0
TLS2_k127_6038098_18 Metallopeptidase family M24 - - - 0.0000000001066 73.0
TLS2_k127_6038098_2 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001108 285.0
TLS2_k127_6038098_3 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006604 278.0
TLS2_k127_6038098_4 ABC transporter K02017,K06857 - 3.6.3.29,3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000000000000008977 269.0
TLS2_k127_6038098_5 Putative methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002131 244.0
TLS2_k127_6038098_6 TIGRFAM DNA binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000303 252.0
TLS2_k127_6038098_7 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000006607 243.0
TLS2_k127_6038098_8 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000001258 238.0
TLS2_k127_6038098_9 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000002892 241.0
TLS2_k127_6055098_0 B12 binding domain - - - 1.296e-275 856.0
TLS2_k127_6055098_1 PFAM glycosyl transferase family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 4.453e-264 833.0
TLS2_k127_6055098_10 phosphatidylcholine synthase activity K01004,K17103 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576 2.7.8.24,2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000001298 229.0
TLS2_k127_6055098_11 Alkaline phosphatase homologues K01077 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000001373 222.0
TLS2_k127_6055098_12 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.0000000000000000000000000000000000000000000000000000001863 205.0
TLS2_k127_6055098_13 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000007637 195.0
TLS2_k127_6055098_14 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000001223 198.0
TLS2_k127_6055098_15 Short chain dehydrogenase - - - 0.000000000000000000000000000000000000000009911 163.0
TLS2_k127_6055098_16 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000009851 138.0
TLS2_k127_6055098_17 - - - - 0.000000000000000000000000000004534 124.0
TLS2_k127_6055098_18 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000002019 124.0
TLS2_k127_6055098_19 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.00000000000000000000000006704 110.0
TLS2_k127_6055098_2 PFAM Stem cell self-renewal protein Piwi - - - 6.143e-264 821.0
TLS2_k127_6055098_20 NMT1-like family - - - 0.00000000000000000002188 102.0
TLS2_k127_6055098_21 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000004943 81.0
TLS2_k127_6055098_22 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K06191 - - 0.000000000003416 68.0
TLS2_k127_6055098_23 nitrite reductase [NAD(P)H] activity K00363 - 1.7.1.15 0.00000000185 63.0
TLS2_k127_6055098_24 Amidohydrolase - - - 0.000002332 52.0
TLS2_k127_6055098_25 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00001652 57.0
TLS2_k127_6055098_3 PFAM glycosyl transferase group 1 K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007469 567.0
TLS2_k127_6055098_4 nuclear-transcribed mRNA catabolic process, no-go decay - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 459.0
TLS2_k127_6055098_5 Fructose-bisphosphate aldolase class-I K01623 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 438.0
TLS2_k127_6055098_6 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002851 388.0
TLS2_k127_6055098_7 PA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 392.0
TLS2_k127_6055098_8 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 377.0
TLS2_k127_6055098_9 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000567 327.0
TLS2_k127_6059315_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002178 279.0
TLS2_k127_6059315_1 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005252 280.0
TLS2_k127_6059315_2 PFAM sigma-54 factor interaction domain-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009832 280.0
TLS2_k127_6059315_3 DsrE/DsrF-like family - - - 0.00000000000000000000000000000000000000000000000000000004488 205.0
TLS2_k127_6059315_4 - - - - 0.0000000000002631 74.0
TLS2_k127_6073668_0 Belongs to the transketolase family K00615 - 2.2.1.1 0.0 1008.0
TLS2_k127_6073668_1 Phosphoglucose isomerase K00616,K13810 - 2.2.1.2,5.3.1.9 2.65e-304 960.0
TLS2_k127_6073668_10 TIGRFAM radical SAM Cys-rich domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009551 398.0
TLS2_k127_6073668_11 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009392 335.0
TLS2_k127_6073668_12 Phosphate transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 334.0
TLS2_k127_6073668_13 Protein of unknown function, DUF547 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 303.0
TLS2_k127_6073668_14 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000002037 250.0
TLS2_k127_6073668_15 transferase activity, transferring glycosyl groups K20742 - 3.4.14.13 0.000000000000000000000000000000000000000000000000000000000000001208 225.0
TLS2_k127_6073668_16 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000006711 199.0
TLS2_k127_6073668_17 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.000000000000000000000000000000000000000000000000002183 192.0
TLS2_k127_6073668_18 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - 0.000000000000000000000000000000000000000000009835 176.0
TLS2_k127_6073668_19 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000006337 183.0
TLS2_k127_6073668_2 Glycosyl hydrolases family 15 - - - 1.51e-239 756.0
TLS2_k127_6073668_20 PFAM HNH endonuclease - - - 0.0000000000000000000000000000000000000000002858 161.0
TLS2_k127_6073668_21 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000001548 142.0
TLS2_k127_6073668_22 Guanylyl transferase CofC like K09931 - - 0.0000000000000000000000000000000000003657 148.0
TLS2_k127_6073668_23 peroxiredoxin activity K03386,K03564,K16922 - 1.11.1.15 0.0000000000000000000000000000917 118.0
TLS2_k127_6073668_24 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000106 126.0
TLS2_k127_6073668_25 Ornithine cyclodeaminase K01750 - 4.3.1.12 0.00000000000000000000000002755 115.0
TLS2_k127_6073668_26 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000002925 113.0
TLS2_k127_6073668_27 Plasmid stabilization system - - - 0.0000000000000000004237 91.0
TLS2_k127_6073668_28 Alpha/beta hydrolase family - - - 0.000000000001722 79.0
TLS2_k127_6073668_29 - - - - 0.00000000116 61.0
TLS2_k127_6073668_3 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 1.622e-194 631.0
TLS2_k127_6073668_30 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.0000001875 59.0
TLS2_k127_6073668_31 AhpC/TSA family - - - 0.00000134 55.0
TLS2_k127_6073668_4 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 601.0
TLS2_k127_6073668_5 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003097 545.0
TLS2_k127_6073668_6 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 479.0
TLS2_k127_6073668_7 Methylase involved in ubiquinone menaquinone biosynthesis K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000934 466.0
TLS2_k127_6073668_8 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 420.0
TLS2_k127_6073668_9 TIGRFAM 6-phosphogluconate dehydrogenase, decarboxylating K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 401.0
TLS2_k127_6090923_0 TIM-barrel fold metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 295.0
TLS2_k127_6090923_1 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000005407 218.0
TLS2_k127_6090923_2 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000001874 219.0
TLS2_k127_6090923_3 dienelactone hydrolase - - - 0.000003052 51.0
TLS2_k127_6159540_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 5.047e-196 636.0
TLS2_k127_6159540_1 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 569.0
TLS2_k127_6159540_10 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 375.0
TLS2_k127_6159540_11 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 366.0
TLS2_k127_6159540_12 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 295.0
TLS2_k127_6159540_13 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001604 288.0
TLS2_k127_6159540_14 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003124 275.0
TLS2_k127_6159540_15 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002084 261.0
TLS2_k127_6159540_16 PFAM D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000001392 209.0
TLS2_k127_6159540_17 Ring hydroxylating beta subunit K14749 - - 0.0000000000000000000000000000000000000000000000007712 179.0
TLS2_k127_6159540_18 Esterase-like activity of phytase - - - 0.0000000000000000000000000000000000000000000007213 180.0
TLS2_k127_6159540_19 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15065 - - 0.00000000000000000000000000000000000000000002429 173.0
TLS2_k127_6159540_2 Malate/L-lactate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 541.0
TLS2_k127_6159540_20 actin binding - - - 0.00000000000000000000000000000000000000000002732 165.0
TLS2_k127_6159540_21 TRAP transporter solute receptor TAXI family protein K07080 - - 0.000000000000000000000000000000000000000002923 169.0
TLS2_k127_6159540_22 endonuclease containing a URI domain K07461 - - 0.000000000000000000000000000000000000007132 147.0
TLS2_k127_6159540_23 cellulose binding - - - 0.0000000000000000000000000000000000007076 153.0
TLS2_k127_6159540_24 Serine dehydrogenase proteinase - - - 0.000000000000000000000000000000008571 139.0
TLS2_k127_6159540_25 protein conserved in bacteria - - - 0.0000000000000000000000000001088 129.0
TLS2_k127_6159540_26 Acetyltransferase (GNAT) domain K18815 - 2.3.1.82 0.0000000000000000000000002594 108.0
TLS2_k127_6159540_27 Acetyltransferase (GNAT) domain K18815 - 2.3.1.82 0.0000000000000000000001645 98.0
TLS2_k127_6159540_28 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000000000000002394 98.0
TLS2_k127_6159540_29 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000341 94.0
TLS2_k127_6159540_3 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 493.0
TLS2_k127_6159540_31 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.00000000000000000000504 98.0
TLS2_k127_6159540_32 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000000000000000001407 92.0
TLS2_k127_6159540_33 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000001205 97.0
TLS2_k127_6159540_34 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000499 87.0
TLS2_k127_6159540_35 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000005084 76.0
TLS2_k127_6159540_36 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00000000000562 77.0
TLS2_k127_6159540_37 ABC transporter substrate-binding protein K02051 - - 0.0000000006923 70.0
TLS2_k127_6159540_38 - - - - 0.0000000008404 63.0
TLS2_k127_6159540_39 RDD family - - - 0.0000000009889 66.0
TLS2_k127_6159540_4 PFAM Glutaredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 481.0
TLS2_k127_6159540_40 Iron-containing redox enzyme K06137 - 1.3.3.11 0.0000001765 61.0
TLS2_k127_6159540_41 SnoaL-like polyketide cyclase - - - 0.000004704 52.0
TLS2_k127_6159540_42 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C K06137 - 1.3.3.11 0.00009716 53.0
TLS2_k127_6159540_43 glyoxalase bleomycin resistance protein dioxygenase K01759 - 4.4.1.5 0.0001119 53.0
TLS2_k127_6159540_44 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000607 47.0
TLS2_k127_6159540_5 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 473.0
TLS2_k127_6159540_6 Belongs to the UbiD family K03182,K16874 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003732 465.0
TLS2_k127_6159540_7 Ring hydroxylating alpha subunit (catalytic domain) K05549,K10619 - 1.14.12.10,1.14.12.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 455.0
TLS2_k127_6159540_8 Rieske (2Fe-2S) domain-containing protein K15060 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006333 415.0
TLS2_k127_6159540_9 PFAM luciferase family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 402.0
TLS2_k127_6167085_0 COG1053 Succinate dehydrogenase fumarate reductase flavoprotein subunit K13796 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 612.0
TLS2_k127_6167085_1 TIGRFAM CitB domain protein K13795 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 377.0
TLS2_k127_6167085_2 Periplasmic component of the Tol biopolymer transport system - - - 0.000000000007541 71.0
TLS2_k127_6167085_3 Tripartite tricarboxylate transporter TctA family - - - 0.000008758 48.0
TLS2_k127_6177839_0 Nuclease-related domain - - - 0.000000000000000000000000000000000000000000000000000000001443 211.0
TLS2_k127_6177839_1 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000005936 179.0
TLS2_k127_6177839_2 Amidohydrolase family - - - 0.000000000000000002567 87.0
TLS2_k127_6177839_3 - - - - 0.00000000003363 68.0
TLS2_k127_6177839_4 PIN domain - - - 0.000001576 51.0
TLS2_k127_6183333_0 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004867 396.0
TLS2_k127_6183333_1 PFAM phosphoesterase, RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 331.0
TLS2_k127_6183333_2 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 0.00000000000000000000000000000000000000000000000000000000009216 222.0
TLS2_k127_6183333_3 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000001587 213.0
TLS2_k127_6183333_4 methyltransferase K22269 - 2.1.1.343 0.00000000000000000000000000000000000000000000000000000005674 211.0
TLS2_k127_6183333_5 Glycolate oxidase subunit K00104 - 1.1.3.15 0.000000000000000000000008031 116.0
TLS2_k127_6183333_6 protein conserved in bacteria - - - 0.00000000001206 74.0
TLS2_k127_6183333_7 lactoylglutathione lyase activity - - - 0.0000000008965 64.0
TLS2_k127_6183333_8 Tripartite tricarboxylate transporter family receptor - - - 0.000000002443 63.0
TLS2_k127_6226734_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1025.0
TLS2_k127_6226734_1 Exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 492.0
TLS2_k127_6226734_2 TOBE domain K02010,K02052 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008849 290.0
TLS2_k127_6226734_3 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000002214 214.0
TLS2_k127_6241451_0 Disulphide bond corrector protein DsbC - - - 0.00000000000000000000000000000000000000000000000000000000000000003401 235.0
TLS2_k127_6241451_1 Peroxiredoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000001825 207.0
TLS2_k127_6241451_2 Uncharacterized ACR, COG1678 K07735 - - 0.000000000000000000000000000000000000000000000000000000000522 214.0
TLS2_k127_6241451_3 Protein of unknown function (DUF465) - - - 0.000000000000000000004668 96.0
TLS2_k127_6241451_4 Protein of unknown function (DUF465) - - - 0.0000003189 59.0
TLS2_k127_6266319_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08352 - 1.8.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006822 380.0
TLS2_k127_6266319_1 Belongs to the LarC family K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 351.0
TLS2_k127_6266319_10 PFAM SNARE associated Golgi protein - - - 0.0000000000000000000000000000001189 138.0
TLS2_k127_6266319_11 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.00000000000000000000000001337 122.0
TLS2_k127_6266319_12 Galactose oxidase, central domain - - - 0.000000000000000000000008043 106.0
TLS2_k127_6266319_13 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing K00183 - - 0.0000000006684 64.0
TLS2_k127_6266319_2 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003893 289.0
TLS2_k127_6266319_3 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003074 278.0
TLS2_k127_6266319_4 Bacterial extracellular solute-binding protein K22003 - 5.3.3.7 0.000000000000000000000000000000000000000000000000000000000000006956 224.0
TLS2_k127_6266319_5 Transmembrane secretion effector K08225 - - 0.000000000000000000000000000000000000000000000000000000000007669 223.0
TLS2_k127_6266319_6 Pfam SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000001546 157.0
TLS2_k127_6266319_7 Alpha/beta hydrolase of unknown function (DUF1100) - - - 0.0000000000000000000000000000000000000102 151.0
TLS2_k127_6266319_8 Pfam SNARE associated Golgi protein - - - 0.000000000000000000000000000000000002006 143.0
TLS2_k127_6266319_9 Glyoxalase-like domain K08234 - - 0.0000000000000000000000000000000001994 137.0
TLS2_k127_6396375_0 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006544 501.0
TLS2_k127_6396375_1 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 455.0
TLS2_k127_6396375_10 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.000000000000000000000000000000000005345 149.0
TLS2_k127_6396375_11 PFAM response regulator receiver K11443 - - 0.0000000000000000000000000000004215 126.0
TLS2_k127_6396375_2 Succinyl-CoA ligase like flavodoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007752 401.0
TLS2_k127_6396375_3 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 317.0
TLS2_k127_6396375_4 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000007273 229.0
TLS2_k127_6396375_5 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000001392 207.0
TLS2_k127_6396375_6 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050 - - 0.000000000000000000000000000000000000000000000000818 178.0
TLS2_k127_6396375_7 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000001374 175.0
TLS2_k127_6396375_8 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.00000000000000000000000000000000000000000000001545 181.0
TLS2_k127_6396375_9 Pfam:TPM K08988 - - 0.0000000000000000000000000000000000000000000009302 181.0
TLS2_k127_6412976_0 Cys/Met metabolism PLP-dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000667 539.0
TLS2_k127_6412976_1 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 383.0
TLS2_k127_6412976_2 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006124 363.0
TLS2_k127_6412976_3 Transition state regulatory protein AbrB K07120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004579 285.0
TLS2_k127_6412976_4 - - - - 0.00000000000000000000000000449 120.0
TLS2_k127_6412976_5 DDE domain K07497 - - 0.0000000000000000000000004645 109.0
TLS2_k127_6412976_6 - - - - 0.0000000000008177 78.0
TLS2_k127_643401_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006657 580.0
TLS2_k127_643401_1 Cupin 2, conserved barrel domain protein K00450,K11948 - 1.13.11.38,1.13.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 452.0
TLS2_k127_643401_2 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000001399 276.0
TLS2_k127_643401_3 Belongs to the mandelate racemase muconate lactonizing enzyme family K19802 - 5.1.1.20 0.00000000000000000000000000000000000000000000000001986 192.0
TLS2_k127_643401_4 PFAM amidohydrolase K07045 - - 0.00000000000000000000000000000001485 140.0
TLS2_k127_643401_5 Transcriptional - - - 0.00000000000000000000000000000006092 128.0
TLS2_k127_643401_6 Iron-containing redox enzyme K06137 - 1.3.3.11 0.00000006996 62.0
TLS2_k127_64383_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000006481 186.0
TLS2_k127_64383_1 PFAM NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000002117 166.0
TLS2_k127_64383_2 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000003754 164.0
TLS2_k127_6454687_0 mandelate racemase muconate lactonizing - - - 0.00000000000000000000000000000000000000000000000002466 187.0
TLS2_k127_6454687_1 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000001502 85.0
TLS2_k127_6474338_0 Belongs to the aldehyde dehydrogenase family K13821 - 1.2.1.88,1.5.5.2 1.397e-294 932.0
TLS2_k127_6474338_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.112e-251 784.0
TLS2_k127_6474338_10 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 331.0
TLS2_k127_6474338_11 PFAM ABC transporter related K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 315.0
TLS2_k127_6474338_12 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007452 310.0
TLS2_k127_6474338_13 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 307.0
TLS2_k127_6474338_14 Galactose oxidase, central domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 298.0
TLS2_k127_6474338_15 Sodium:sulfate symporter transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 313.0
TLS2_k127_6474338_16 Nitrile hydratase, alpha chain K01721 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002555 288.0
TLS2_k127_6474338_17 Cytidylyltransferase K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002803 278.0
TLS2_k127_6474338_18 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000341 285.0
TLS2_k127_6474338_19 NMT1-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000001251 236.0
TLS2_k127_6474338_2 Asparaginase - - - 1.29e-205 656.0
TLS2_k127_6474338_20 MoaE protein K21142 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000000000000002549 232.0
TLS2_k127_6474338_21 FAD metabolic process K00953,K15429 GO:0003674,GO:0003824,GO:0003919,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042726,GO:0042727,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046443,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0070566,GO:0071704,GO:0071944,GO:0072387,GO:0072388,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.228,2.7.7.2 0.0000000000000000000000000000000000000000000000000000007584 200.0
TLS2_k127_6474338_22 Mo-molybdopterin cofactor metabolic process K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000000000002788 196.0
TLS2_k127_6474338_23 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000001129 199.0
TLS2_k127_6474338_24 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000000000008764 182.0
TLS2_k127_6474338_25 Amidohydrolase - - - 0.000000000000000000000000000000000000000000001873 186.0
TLS2_k127_6474338_26 Phage derived protein Gp49-like (DUF891) - - - 0.000000000000000000000000000000000000000000007565 164.0
TLS2_k127_6474338_27 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.000000000000000000000000000000000000000000011 168.0
TLS2_k127_6474338_28 PFAM Phage derived protein Gp49-like (DUF891) - - - 0.000000000000000000000000000000000000000005778 156.0
TLS2_k127_6474338_29 PFAM amidohydrolase K07045 - - 0.000000000000000000000000000000000000006858 159.0
TLS2_k127_6474338_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 603.0
TLS2_k127_6474338_30 protein conserved in bacteria - - - 0.000000000000000000000000000000000002134 152.0
TLS2_k127_6474338_31 addiction module antidote protein HigA - - - 0.00000000000000000000000000000000003698 138.0
TLS2_k127_6474338_32 - - - - 0.0000000000000000000000000000000006979 133.0
TLS2_k127_6474338_33 membrane-associated protein K03975 - - 0.0000000000000000000000000000003526 130.0
TLS2_k127_6474338_35 peptidase, M24 - - - 0.0000000000000000000000000001408 129.0
TLS2_k127_6474338_36 - - - - 0.000000000000000000002309 96.0
TLS2_k127_6474338_37 PTS HPr component phosphorylation site K11189 - - 0.00000000000000000008285 93.0
TLS2_k127_6474338_38 Transmembrane secretion effector - - - 0.000000000000000002792 87.0
TLS2_k127_6474338_39 OstA-like protein K09774 - - 0.00000000000002309 81.0
TLS2_k127_6474338_4 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008085 560.0
TLS2_k127_6474338_41 Glyoxalase-like domain - - - 0.0000000005388 70.0
TLS2_k127_6474338_42 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.000000005768 67.0
TLS2_k127_6474338_43 Hydantoin racemase K16841 - 5.1.99.3 0.00000001422 67.0
TLS2_k127_6474338_45 - - - - 0.0000257 55.0
TLS2_k127_6474338_46 NHase catalyzes the hydration of various nitrile compounds to the corresponding amides K20807 - 4.2.1.84 0.00002767 51.0
TLS2_k127_6474338_47 Domain of unknown function (DUF4926) - - - 0.00003034 49.0
TLS2_k127_6474338_48 Lipopolysaccharide-assembly, LptC-related - - - 0.0001873 51.0
TLS2_k127_6474338_5 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 545.0
TLS2_k127_6474338_6 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 469.0
TLS2_k127_6474338_7 alpha/beta hydrolase fold K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008082 381.0
TLS2_k127_6474338_8 SIS domain K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005367 370.0
TLS2_k127_6474338_9 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 367.0
TLS2_k127_6488205_0 Cupin domain K00450 - 1.13.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007909 320.0
TLS2_k127_6488205_1 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000001541 238.0
TLS2_k127_6488205_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000003724 192.0
TLS2_k127_6488205_3 ABC transporter substrate-binding protein K02051 - - 0.00000000001201 76.0
TLS2_k127_6488205_4 NMT1/THI5 like - - - 0.00000002263 65.0
TLS2_k127_6488205_5 TIGRFAM ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.00000002566 65.0
TLS2_k127_6549963_0 aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 445.0
TLS2_k127_6549963_1 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009359 309.0
TLS2_k127_6549963_2 COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005717 280.0
TLS2_k127_6549963_3 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005932 276.0
TLS2_k127_6549963_4 Uncharacterized conserved protein (DUF2294) - - - 0.0000000000000000000000000001754 120.0
TLS2_k127_6549963_5 Endoribonuclease L-PSP - - - 0.000000000000000000000001782 106.0
TLS2_k127_6626596_0 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000002898 204.0
TLS2_k127_6626596_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.000000000000000000000006304 105.0
TLS2_k127_6626596_2 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - 0.000000000002467 70.0
TLS2_k127_6626596_3 oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor K10672,K10794 - 1.21.4.1,1.21.4.2 0.000000009908 63.0
TLS2_k127_6626596_4 - - - - 0.000003876 52.0
TLS2_k127_6636611_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 1.162e-271 846.0
TLS2_k127_6636611_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 5.803e-224 699.0
TLS2_k127_6636611_10 TolB amino-terminal domain K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 354.0
TLS2_k127_6636611_11 PDZ domain (Also known as DHR or GLGF) K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 349.0
TLS2_k127_6636611_12 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005235 341.0
TLS2_k127_6636611_13 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 311.0
TLS2_k127_6636611_14 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006778 282.0
TLS2_k127_6636611_15 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000001445 270.0
TLS2_k127_6636611_16 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000006662 263.0
TLS2_k127_6636611_17 TIGRFAM riboflavin biosynthesis protein RibF K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000001696 255.0
TLS2_k127_6636611_18 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000008437 250.0
TLS2_k127_6636611_19 ACT domain K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000005971 240.0
TLS2_k127_6636611_2 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 606.0
TLS2_k127_6636611_20 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000002472 239.0
TLS2_k127_6636611_21 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000844 233.0
TLS2_k127_6636611_22 MotA/TolQ/ExbB proton channel family K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000008937 230.0
TLS2_k127_6636611_23 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000139 212.0
TLS2_k127_6636611_24 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000286 190.0
TLS2_k127_6636611_25 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.00000000000000000000000000000000000000002067 162.0
TLS2_k127_6636611_26 PFAM Peptidase M22, glycoprotease K14742 - - 0.00000000000000000000000000000000000000004507 160.0
TLS2_k127_6636611_27 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000000000000000000000000307 141.0
TLS2_k127_6636611_28 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000002379 130.0
TLS2_k127_6636611_29 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000008139 113.0
TLS2_k127_6636611_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 478.0
TLS2_k127_6636611_30 Glycine-zipper domain - - - 0.0000000000000000000005145 106.0
TLS2_k127_6636611_31 PFAM Preprotein translocase SecG subunit K03075 - - 0.0000000000000000001476 92.0
TLS2_k127_6636611_32 Polymer-forming cytoskeletal - - - 0.000000000000000002346 90.0
TLS2_k127_6636611_34 Tripartite tricarboxylate transporter family receptor - - - 0.000000001365 68.0
TLS2_k127_6636611_35 Helix-turn-helix domain - - - 0.000000006811 60.0
TLS2_k127_6636611_36 TonB C terminal K03646 - - 0.00003892 55.0
TLS2_k127_6636611_4 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 465.0
TLS2_k127_6636611_5 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 449.0
TLS2_k127_6636611_6 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009668 422.0
TLS2_k127_6636611_7 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 415.0
TLS2_k127_6636611_8 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 389.0
TLS2_k127_6636611_9 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 387.0
TLS2_k127_6646788_0 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 316.0
TLS2_k127_6646788_1 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001503 252.0
TLS2_k127_6646788_2 Serine aminopeptidase, S33 K01055 - 3.1.1.24 0.000000000000000000001502 99.0
TLS2_k127_6650295_0 succinate dehydrogenase, flavoprotein subunit K00239 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4 1.649e-289 900.0
TLS2_k127_6650295_1 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004807 582.0
TLS2_k127_6650295_10 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006881 391.0
TLS2_k127_6650295_11 Major Facilitator Superfamily K02575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 365.0
TLS2_k127_6650295_12 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 310.0
TLS2_k127_6650295_13 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 318.0
TLS2_k127_6650295_14 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008266 293.0
TLS2_k127_6650295_15 dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002406 271.0
TLS2_k127_6650295_16 NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003245 257.0
TLS2_k127_6650295_17 thiolester hydrolase activity K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002071 256.0
TLS2_k127_6650295_18 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000003495 225.0
TLS2_k127_6650295_19 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.0000000000000000000000000000000000000000000000000000001797 214.0
TLS2_k127_6650295_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006004 589.0
TLS2_k127_6650295_20 Enoyl-(Acyl carrier protein) reductase K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000001702 191.0
TLS2_k127_6650295_21 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000002802 183.0
TLS2_k127_6650295_22 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000000000002496 180.0
TLS2_k127_6650295_23 NMT1-like family - - - 0.00000000000000000000000000000000000000000001744 175.0
TLS2_k127_6650295_24 Enoyl-CoA hydratase/isomerase K08299 - 4.2.1.149 0.000000000000000000000000000000000003694 147.0
TLS2_k127_6650295_25 Domain of unknown function (DUF3817) - - - 0.000000000000000000000000000001473 124.0
TLS2_k127_6650295_26 PFAM Peptidase M19, renal dipeptidase K01273 - 3.4.13.19 0.00000000000000000000000000005145 123.0
TLS2_k127_6650295_27 Fic/DOC family K07341 - - 0.00000000000000000008993 90.0
TLS2_k127_6650295_28 NMT1-like family K02051 - - 0.0000000000000000001348 98.0
TLS2_k127_6650295_29 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000001895 100.0
TLS2_k127_6650295_3 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008949 569.0
TLS2_k127_6650295_30 - - - - 0.000000000000000001425 88.0
TLS2_k127_6650295_31 Fic/DOC family K07341 - - 0.00000000000000001655 86.0
TLS2_k127_6650295_32 Ferredoxin - - - 0.0000000000000001354 83.0
TLS2_k127_6650295_33 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.00000000000001646 75.0
TLS2_k127_6650295_34 Metallo-beta-lactamase superfamily K05555 - - 0.00000000000002205 83.0
TLS2_k127_6650295_35 bacterial OsmY and nodulation domain K04065 - - 0.00000000003281 69.0
TLS2_k127_6650295_36 COGs COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.0000000001969 72.0
TLS2_k127_6650295_37 domain protein - - - 0.00000009838 55.0
TLS2_k127_6650295_38 ABC transporter substrate-binding protein K02051 - - 0.000005708 55.0
TLS2_k127_6650295_39 Maleate cis-trans isomerase K01799 - 5.2.1.1 0.00003569 48.0
TLS2_k127_6650295_4 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 520.0
TLS2_k127_6650295_40 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0003254 48.0
TLS2_k127_6650295_41 Early endosome antigen 1 K12478 GO:0003674,GO:0005488,GO:0005515,GO:0005516,GO:0005543,GO:0005545,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0005969,GO:0006810,GO:0006897,GO:0006906,GO:0006996,GO:0008150,GO:0008270,GO:0008289,GO:0009987,GO:0010008,GO:0012505,GO:0016020,GO:0016032,GO:0016043,GO:0016050,GO:0016189,GO:0016192,GO:0016197,GO:0016482,GO:0019058,GO:0019079,GO:0019897,GO:0019898,GO:0030139,GO:0030424,GO:0030742,GO:0031090,GO:0031410,GO:0031901,GO:0031982,GO:0032266,GO:0032991,GO:0033267,GO:0035091,GO:0039694,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0044308,GO:0044309,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045022,GO:0046872,GO:0046907,GO:0046914,GO:0046983,GO:0048284,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051704,GO:0055037,GO:0061024,GO:0061025,GO:0071840,GO:0071944,GO:0090174,GO:0097458,GO:0097708,GO:0098588,GO:0098657,GO:0098805,GO:0098927,GO:0099003,GO:0099504,GO:0099532,GO:0120025,GO:0120038,GO:1901981,GO:1902494,GO:1990234 - 0.000337 54.0
TLS2_k127_6650295_5 twitching motility protein K02670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 514.0
TLS2_k127_6650295_6 Belongs to the aldehyde dehydrogenase family K00135,K22445 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.99.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 473.0
TLS2_k127_6650295_7 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000915 454.0
TLS2_k127_6650295_8 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 392.0
TLS2_k127_6650295_9 Succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 385.0
TLS2_k127_6659168_0 Flavin containing amine oxidoreductase - - - 1.123e-256 800.0
TLS2_k127_6659168_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004149 575.0
TLS2_k127_6659168_10 PFAM Peptidase M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 325.0
TLS2_k127_6659168_11 exonuclease activity K16899 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008943 302.0
TLS2_k127_6659168_12 RadC-like JAB domain K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007179 280.0
TLS2_k127_6659168_13 Cyclodeaminase K01750,K19244 - 1.4.1.1,4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000002892 262.0
TLS2_k127_6659168_14 Fumarylacetoacetate (FAA) hydrolase family K16164 - 3.7.1.5 0.000000000000000000000000000000000000000000000000000000000000000000002706 246.0
TLS2_k127_6659168_15 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000001066 230.0
TLS2_k127_6659168_16 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000524 219.0
TLS2_k127_6659168_17 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000315 213.0
TLS2_k127_6659168_18 protein conserved in bacteria K09922 - - 0.00000000000000000000000000000000000000000001589 163.0
TLS2_k127_6659168_19 Acid phosphatase homologues K12978 - - 0.000000000000000000000000000000000000000002006 165.0
TLS2_k127_6659168_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 562.0
TLS2_k127_6659168_20 ornithine cyclodeaminase K01750,K19244 - 1.4.1.1,4.3.1.12 0.00000000000000000000000000000000000008213 156.0
TLS2_k127_6659168_21 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.0000000000000000000000000000003081 130.0
TLS2_k127_6659168_22 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000003366 117.0
TLS2_k127_6659168_23 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000004422 120.0
TLS2_k127_6659168_24 Bacterial protein of unknown function (DUF883) - - - 0.00000000000000000000000007349 109.0
TLS2_k127_6659168_25 lactoylglutathione lyase activity - - - 0.0000000000000000000003796 107.0
TLS2_k127_6659168_26 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.00000000000000001401 89.0
TLS2_k127_6659168_27 MFS/sugar transport protein K08223 - - 0.00000000000001861 86.0
TLS2_k127_6659168_29 Belongs to the UPF0235 family K09131 - - 0.00000000005502 68.0
TLS2_k127_6659168_3 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 510.0
TLS2_k127_6659168_30 lactoylglutathione lyase activity - - - 0.0000000003467 70.0
TLS2_k127_6659168_31 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000122 59.0
TLS2_k127_6659168_4 Psort location Periplasmic, score 9.44 K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 480.0
TLS2_k127_6659168_5 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007323 443.0
TLS2_k127_6659168_6 Glycine cleavage T-protein C-terminal barrel domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 433.0
TLS2_k127_6659168_7 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000502 416.0
TLS2_k127_6659168_8 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 378.0
TLS2_k127_6659168_9 SMART PUA domain containing protein K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 348.0
TLS2_k127_6674104_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 3.033e-210 668.0
TLS2_k127_6674104_1 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 394.0
TLS2_k127_6674104_10 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000001769 218.0
TLS2_k127_6674104_11 Memo-like protein K06990 - - 0.0000000000000000000000000000000000000000000000000001091 197.0
TLS2_k127_6674104_12 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.0000000000000000000000000000000000000000000004225 185.0
TLS2_k127_6674104_13 Belongs to the P-Pant transferase superfamily K06133 - - 0.0000000000000000000000000000000000000000000008094 175.0
TLS2_k127_6674104_14 DNA polymerase III, delta' K02340 - 2.7.7.7 0.0000000000000000000000000000000000002539 157.0
TLS2_k127_6674104_15 Uridine phosphorylase K00757 - 2.4.2.3 0.0000000000000000000000000000000002766 142.0
TLS2_k127_6674104_16 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.000000000000000000000000000001903 129.0
TLS2_k127_6674104_17 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000449 119.0
TLS2_k127_6674104_18 SMART phospholipase D Transphosphatidylase - - - 0.0000000000000000000000002069 113.0
TLS2_k127_6674104_2 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006679 321.0
TLS2_k127_6674104_21 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.0000000000000000001815 100.0
TLS2_k127_6674104_22 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 0.000000000000003941 78.0
TLS2_k127_6674104_23 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000009449 80.0
TLS2_k127_6674104_24 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.00000000000003265 76.0
TLS2_k127_6674104_25 PFAM beta-lactamase domain protein - - - 0.00000002896 62.0
TLS2_k127_6674104_3 FAH family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004939 289.0
TLS2_k127_6674104_4 thiolester hydrolase activity K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002247 289.0
TLS2_k127_6674104_5 subfamily IA, variant 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000206 269.0
TLS2_k127_6674104_6 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001751 260.0
TLS2_k127_6674104_7 Amidohydrolase K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000001431 250.0
TLS2_k127_6674104_8 Cysteine-rich domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002802 235.0
TLS2_k127_6674104_9 PFAM peptidase S11, D-alanyl-D-alanine carboxypeptidase K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000002566 233.0
TLS2_k127_6695867_0 Sugar (and other) transporter K08178 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 390.0
TLS2_k127_6695867_1 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 337.0
TLS2_k127_6695867_10 Ndr family - - - 0.00000000000000000000000000005119 127.0
TLS2_k127_6695867_11 Iron-binding zinc finger CDGSH type - - - 0.000000000000004932 78.0
TLS2_k127_6695867_12 NMT1-like family - - - 0.0000000000005618 80.0
TLS2_k127_6695867_13 AraC-like ligand binding domain - - - 0.000006202 54.0
TLS2_k127_6695867_2 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 319.0
TLS2_k127_6695867_3 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 291.0
TLS2_k127_6695867_4 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000001235 266.0
TLS2_k127_6695867_5 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000028 256.0
TLS2_k127_6695867_6 Carboxylesterase family K01432 - 3.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000003536 230.0
TLS2_k127_6695867_7 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000002248 199.0
TLS2_k127_6695867_8 Outer membrane protein beta-barrel domain K16079 - - 0.000000000000000000000000000000000000009425 155.0
TLS2_k127_6695867_9 Amidohydrolase K03392 - 4.1.1.45 0.0000000000000000000000000000000002139 144.0
TLS2_k127_6719180_0 TIGRFAM molybdenum cofactor synthesis K03750,K07219 - 2.10.1.1 2.307e-203 651.0
TLS2_k127_6719180_1 TIGRFAM molybdenum cofactor synthesis domain K03750 - 2.10.1.1 0.000000000000000001242 88.0
TLS2_k127_6736325_0 Bacterial regulatory protein, Fis family K07715 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009776 607.0
TLS2_k127_6736325_1 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03669 GO:0005575,GO:0016020 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 619.0
TLS2_k127_6736325_10 Domain of unknown function (DUF4168) - - - 0.0001007 50.0
TLS2_k127_6736325_2 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 496.0
TLS2_k127_6736325_3 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000006132 210.0
TLS2_k127_6736325_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.00000000000000000000000000000000000000001701 162.0
TLS2_k127_6736325_5 AAA domain K02450 - - 0.000000000000000000000000001371 129.0
TLS2_k127_6736325_6 lytic transglycosylase activity - - - 0.000000000000000004285 93.0
TLS2_k127_6736325_7 response regulator K02490 - - 0.000000000000004601 81.0
TLS2_k127_6736325_8 Sigma-54 interaction domain K02481 - - 0.00000000002054 70.0
TLS2_k127_6736325_9 - - - - 0.0000002482 55.0
TLS2_k127_6744943_0 PFAM Na Pi-cotransporter K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006819 497.0
TLS2_k127_6744943_1 nuclear-transcribed mRNA catabolic process, no-go decay - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 370.0
TLS2_k127_6773071_0 TRAP transporter, 4TM 12TM fusion protein - - - 2.015e-275 860.0
TLS2_k127_6773071_1 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 465.0
TLS2_k127_6773071_10 PFAM Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 341.0
TLS2_k127_6773071_11 Pfam Cupin K00450,K11948 - 1.13.11.38,1.13.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007929 289.0
TLS2_k127_6773071_12 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000025 280.0
TLS2_k127_6773071_13 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000002404 228.0
TLS2_k127_6773071_14 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000003344 173.0
TLS2_k127_6773071_15 Amidohydrolase K07045 - - 0.000000000000000000000000000000000001728 151.0
TLS2_k127_6773071_16 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.000000000000000000000000000009856 129.0
TLS2_k127_6773071_17 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000008789 113.0
TLS2_k127_6773071_18 membrane protein domain - - - 0.00000000000000000000007541 105.0
TLS2_k127_6773071_19 NMT1-like family - - - 0.00000000000002739 84.0
TLS2_k127_6773071_2 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004534 457.0
TLS2_k127_6773071_20 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 - 3.5.99.2 0.000000001694 67.0
TLS2_k127_6773071_21 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000003315 61.0
TLS2_k127_6773071_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005749 403.0
TLS2_k127_6773071_4 TRAP transporter, solute receptor (TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 382.0
TLS2_k127_6773071_5 protein histidine kinase activity K07315,K07641,K10819,K13924 - 2.1.1.80,2.7.13.3,3.1.1.61,3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 408.0
TLS2_k127_6773071_6 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K15585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 353.0
TLS2_k127_6773071_7 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 343.0
TLS2_k127_6773071_8 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 338.0
TLS2_k127_6773071_9 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 338.0
TLS2_k127_6812358_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 576.0
TLS2_k127_6812358_1 serine-type endopeptidase activity K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 518.0
TLS2_k127_6812358_10 TIM-barrel fold metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002556 265.0
TLS2_k127_6812358_11 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000627 257.0
TLS2_k127_6812358_12 major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001074 252.0
TLS2_k127_6812358_13 Domain of unknown function (DUF1932) - - - 0.0000000000000000000000000000000000000000000000000000000000005361 220.0
TLS2_k127_6812358_14 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.0000000000000000000000000000000000000000003643 162.0
TLS2_k127_6812358_15 Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000004613 156.0
TLS2_k127_6812358_16 - - - - 0.00000000000000000000000000000000000000197 153.0
TLS2_k127_6812358_17 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000007995 130.0
TLS2_k127_6812358_18 Ornithine cyclodeaminase/mu-crystallin family - - - 0.000000000000000000000000000001627 126.0
TLS2_k127_6812358_19 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000001038 121.0
TLS2_k127_6812358_2 PFAM O-methyltransferase family 2 K09846 - 2.1.1.210 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003772 404.0
TLS2_k127_6812358_20 YCII-related domain - - - 0.00000000000000000000001723 103.0
TLS2_k127_6812358_21 Belongs to the Nudix hydrolase family - - - 0.0000000000000000000001604 103.0
TLS2_k127_6812358_22 Catalyzes the conversion of maleate to fumarate K01799 - 5.2.1.1 0.00000000000000000001275 102.0
TLS2_k127_6812358_23 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000007252 97.0
TLS2_k127_6812358_24 Universal stress protein family - - - 0.000000000000000001046 91.0
TLS2_k127_6812358_25 Ornithine cyclodeaminase/mu-crystallin family - - - 0.000000000000000002612 86.0
TLS2_k127_6812358_26 NMT1-like family - - - 0.0000000003271 72.0
TLS2_k127_6812358_27 NMT1-like family K02051 - - 0.00000006584 62.0
TLS2_k127_6812358_28 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.000004154 56.0
TLS2_k127_6812358_29 Evidence 5 No homology to any previously reported sequences - - - 0.00003168 53.0
TLS2_k127_6812358_3 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 397.0
TLS2_k127_6812358_30 Maleate cis-trans isomerase K01799 - 5.2.1.1 0.0002091 52.0
TLS2_k127_6812358_4 PFAM Rhodanese domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 389.0
TLS2_k127_6812358_5 lactate metabolic process K00113 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 382.0
TLS2_k127_6812358_6 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004418 316.0
TLS2_k127_6812358_7 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005729 329.0
TLS2_k127_6812358_8 Iron-containing redox enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009836 314.0
TLS2_k127_6812358_9 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000699 278.0
TLS2_k127_6830695_0 Sigma-54 interaction domain K07714,K07715 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 613.0
TLS2_k127_6830695_1 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0016672,GO:0016675,GO:0019538,GO:0030091,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0043546,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0055114,GO:0071704,GO:0097159,GO:1901363,GO:1901530,GO:1901564,GO:1901700 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000586 440.0
TLS2_k127_6830695_10 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010181,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019538,GO:0020037,GO:0030091,GO:0031224,GO:0031226,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000006337 239.0
TLS2_k127_6830695_11 TatD related DNase K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000006069 231.0
TLS2_k127_6830695_12 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000004961 225.0
TLS2_k127_6830695_13 dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000001005 214.0
TLS2_k127_6830695_14 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000003546 217.0
TLS2_k127_6830695_15 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000008055 195.0
TLS2_k127_6830695_16 - - - - 0.00000000000000000000000000000000000000000000000001285 182.0
TLS2_k127_6830695_17 Redoxin - - - 0.0000000000000000000000000000004045 124.0
TLS2_k127_6830695_18 chlorophyll binding K02051,K03286 - - 0.000000000000000000000142 108.0
TLS2_k127_6830695_19 nuclear chromosome segregation - - - 0.000000000000001036 85.0
TLS2_k127_6830695_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 428.0
TLS2_k127_6830695_20 Transcriptional regulator K07669 - - 0.0000000000001988 78.0
TLS2_k127_6830695_21 RmuC family K09760 - - 0.000000003869 62.0
TLS2_k127_6830695_22 Thioredoxin-like - - - 0.0000003245 57.0
TLS2_k127_6830695_23 - - - - 0.0002481 49.0
TLS2_k127_6830695_24 EamA-like transporter family - - - 0.0003834 51.0
TLS2_k127_6830695_3 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 393.0
TLS2_k127_6830695_4 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 391.0
TLS2_k127_6830695_5 Mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 346.0
TLS2_k127_6830695_6 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 297.0
TLS2_k127_6830695_7 PFAM thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005429 291.0
TLS2_k127_6830695_8 TIGRFAM MazG family protein K02428,K02499 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000004799 255.0
TLS2_k127_6830695_9 A G-specific K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005124 253.0
TLS2_k127_6833100_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00520,K21739 - 1.16.1.1 5.453e-237 740.0
TLS2_k127_6833100_1 - - - - 0.00000000000000000000000000000000000000000000000000000002782 201.0
TLS2_k127_6833100_2 acetyltransferase - - - 0.000000000000000000000000001665 119.0
TLS2_k127_6833100_3 - - - - 0.00000000000000000002113 100.0
TLS2_k127_6833100_4 Protein involved in outer membrane biogenesis K07289 - - 0.00000000000000000002266 107.0
TLS2_k127_6833100_5 Protein conserved in bacteria - - - 0.0000000000001536 76.0
TLS2_k127_6833100_6 excinuclease ABC activity K02342,K03703,K04096 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 0.000000106 64.0
TLS2_k127_6833100_7 Domain of unknown function (DUF427) - - - 0.0000003845 56.0
TLS2_k127_6833100_8 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03749 - - 0.00006907 55.0
TLS2_k127_6833100_9 - - - - 0.0007114 47.0
TLS2_k127_6876238_0 PFAM nickel-dependent hydrogenase, large subunit K00436,K14126 - 1.12.1.2,1.8.98.5 1.05e-220 692.0
TLS2_k127_6876238_1 PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit K00335,K05587 - 1.6.5.3 3.905e-219 692.0
TLS2_k127_6876238_2 PFAM HypF finger K04656 - - 1.001e-217 690.0
TLS2_k127_6876238_3 PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K05299,K05588 - 1.17.1.10,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006999 377.0
TLS2_k127_6876238_4 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14128,K18007 - 1.12.1.2,1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000003092 238.0
TLS2_k127_6876238_5 Thioredoxin-like [2Fe-2S] ferredoxin K05586 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000009574 200.0
TLS2_k127_6876238_6 Initiates the rapid degradation of small, acid-soluble proteins during spore germination - - - 0.000000000000000000000002283 111.0
TLS2_k127_6876238_7 Zn finger protein HypA HybF (Possibly regulating hydrogenase expression) K04651 - - 0.000000000000002353 81.0
TLS2_k127_6893107_0 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 317.0
TLS2_k127_6893107_1 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000076 259.0
TLS2_k127_6893107_2 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000006752 171.0
TLS2_k127_6893107_3 Domain of unknown function (DUF427) - - - 0.00000000000000000000000000000000000002838 146.0
TLS2_k127_6894285_0 aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003705 410.0
TLS2_k127_6894285_1 MmgE/PrpD family K01720 - 4.2.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 400.0
TLS2_k127_6894285_2 peroxisomal (S)-2-hydroxy-acid oxidase K11517 GO:0002218,GO:0002253,GO:0002376,GO:0002682,GO:0002684,GO:0003674,GO:0003824,GO:0003973,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006950,GO:0006952,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008891,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009853,GO:0009987,GO:0010109,GO:0010204,GO:0016032,GO:0016491,GO:0016614,GO:0016899,GO:0016999,GO:0017000,GO:0017144,GO:0019048,GO:0019222,GO:0023052,GO:0031323,GO:0031347,GO:0031349,GO:0035821,GO:0042579,GO:0042742,GO:0042743,GO:0043094,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044003,GO:0044237,GO:0044249,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045088,GO:0045089,GO:0048518,GO:0048583,GO:0048584,GO:0050665,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0055114,GO:0065007,GO:0072593,GO:0080134,GO:0098542,GO:1903409 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 309.0
TLS2_k127_6894285_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.00000000000000000000000000000000001151 145.0
TLS2_k127_6894285_5 PFAM Cupin - - - 0.000001662 57.0
TLS2_k127_6902282_0 PFAM Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 393.0
TLS2_k127_6902282_1 PFAM Transketolase central region K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 390.0
TLS2_k127_6902282_2 Dehydrogenase E1 component K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 371.0
TLS2_k127_6902282_3 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162,K11381 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 368.0
TLS2_k127_6902282_4 PFAM dehydrogenase, E1 component K21416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 297.0
TLS2_k127_6902282_5 F420-dependent oxidoreductase, MSMEG_3544 family - - - 0.000000000000000000000000000000000000000000000000000000127 206.0
TLS2_k127_6902282_6 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000007506 168.0
TLS2_k127_6902282_7 Cupin domain - - - 0.0000000000000000000000000000002862 128.0
TLS2_k127_6902282_8 NMT1-like family K02051 - - 0.00000000000000000005979 102.0
TLS2_k127_6902282_9 EamA-like transporter family - - - 0.0000000000001724 81.0
TLS2_k127_6903837_0 TRAP transporter, 4TM 12TM fusion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000292 570.0
TLS2_k127_6903837_1 TRAP transporter, solute receptor (TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 366.0
TLS2_k127_6906427_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 583.0
TLS2_k127_6906427_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004028 549.0
TLS2_k127_6906427_10 Class ii aldolase K01628,K03077 - 4.1.2.17,5.1.3.4 0.000000000000000000000000000000000000000000001481 173.0
TLS2_k127_6906427_11 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000002466 140.0
TLS2_k127_6906427_12 PFAM amidohydrolase K07045 - - 0.000000000000000000000000000001071 134.0
TLS2_k127_6906427_13 glyoxalase bleomycin resistance protein dioxygenase K01759,K08234 - 4.4.1.5 0.00000000000000000191 91.0
TLS2_k127_6906427_14 Cupin 2, conserved barrel domain protein K00971,K01809,K16011 - 2.7.7.13,5.3.1.8 0.000000000009191 72.0
TLS2_k127_6906427_2 Deoxyhypusine synthase K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 530.0
TLS2_k127_6906427_3 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 338.0
TLS2_k127_6906427_4 TIM-barrel fold metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001422 252.0
TLS2_k127_6906427_5 acyl-CoA transferases carnitine dehydratase K18702 - 2.8.3.19 0.00000000000000000000000000000000000000000000000000000000000000000009258 246.0
TLS2_k127_6906427_6 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000003916 206.0
TLS2_k127_6906427_7 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000001108 198.0
TLS2_k127_6906427_8 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.000000000000000000000000000000000000000000000000003994 192.0
TLS2_k127_6906427_9 Phosphoenolpyruvate phosphomutase K20454 - 4.1.3.32 0.000000000000000000000000000000000000000000000000004226 192.0
TLS2_k127_6929783_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 2.67e-206 656.0
TLS2_k127_6929783_1 Na+-transporting oxaloacetate decarboxylase beta subunit K01572 - 4.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 511.0
TLS2_k127_6929783_10 Cytochrome oxidase assembly protein K02259,K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001688 281.0
TLS2_k127_6929783_11 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004362 273.0
TLS2_k127_6929783_12 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001486 260.0
TLS2_k127_6929783_13 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000004364 254.0
TLS2_k127_6929783_14 Aerotolerance regulator N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007344 262.0
TLS2_k127_6929783_15 PFAM Prenyltransferase squalene oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000001775 227.0
TLS2_k127_6929783_16 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.00000000000000000000000000000000000000000000000000000000000001167 231.0
TLS2_k127_6929783_17 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000001988 221.0
TLS2_k127_6929783_18 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000005091 201.0
TLS2_k127_6929783_19 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000000002444 173.0
TLS2_k127_6929783_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005435 395.0
TLS2_k127_6929783_20 Zn-dependent hydrolases of the - - - 0.0000000000000000000000000000000000000000000008682 176.0
TLS2_k127_6929783_21 Cytochrome c oxidase, subunit III K02276,K02299 - 1.9.3.1 0.000000000000000000000000000000000000000000002226 173.0
TLS2_k127_6929783_22 Protein of unknown function (DUF420) K08976 - - 0.00000000000000000000000000000000000000000006812 165.0
TLS2_k127_6929783_23 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000004987 173.0
TLS2_k127_6929783_24 Pfam:DUF59 K02612 - - 0.000000000000000000000000000000000001927 139.0
TLS2_k127_6929783_25 Cytochrome c oxidase subunit III K02276,K02299 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 0.00000000000000000000000002289 117.0
TLS2_k127_6929783_26 Belongs to the ompA family - - - 0.000000000000000000000005575 110.0
TLS2_k127_6929783_27 PFAM Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.0000000000000000003495 94.0
TLS2_k127_6929783_28 - - - - 0.000000000000000006789 87.0
TLS2_k127_6929783_29 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.00000000000000006248 82.0
TLS2_k127_6929783_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005003 381.0
TLS2_k127_6929783_30 Evidence 5 No homology to any previously reported sequences - - - 0.000000000002548 76.0
TLS2_k127_6929783_31 Biotin-requiring enzyme - - - 0.0000000000138 67.0
TLS2_k127_6929783_32 PFAM carboxyl transferase K01966,K17489 - 2.1.3.1,2.1.3.15,6.4.1.3 0.0000000000382 71.0
TLS2_k127_6929783_33 NMT1-like family - - - 0.00000000263 68.0
TLS2_k127_6929783_34 Protein of unknown function (DUF2283) - - - 0.0000000179 59.0
TLS2_k127_6929783_35 integral membrane protein - - - 0.000002294 56.0
TLS2_k127_6929783_37 Cell Wall K01448 - 3.5.1.28 0.00003951 53.0
TLS2_k127_6929783_38 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00005258 49.0
TLS2_k127_6929783_39 Belongs to the ompA family - - - 0.0001911 49.0
TLS2_k127_6929783_4 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 374.0
TLS2_k127_6929783_5 Putative glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 374.0
TLS2_k127_6929783_6 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 316.0
TLS2_k127_6929783_7 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 298.0
TLS2_k127_6929783_8 Memo-like protein K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002949 294.0
TLS2_k127_6929783_9 alcohol dehydrogenase K00001,K00008 - 1.1.1.1,1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005957 291.0
TLS2_k127_6977839_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1390.0
TLS2_k127_6977839_1 DNA topoisomerase II activity K03167 - 5.99.1.3 2.114e-296 924.0
TLS2_k127_6977839_10 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 433.0
TLS2_k127_6977839_11 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 419.0
TLS2_k127_6977839_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 381.0
TLS2_k127_6977839_13 Short chain dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 365.0
TLS2_k127_6977839_14 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007378 363.0
TLS2_k127_6977839_15 PhoPQ-activated pathogenicity-related protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 353.0
TLS2_k127_6977839_16 Thiamine pyrophosphate enzyme, central domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007675 357.0
TLS2_k127_6977839_17 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004376 340.0
TLS2_k127_6977839_18 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 323.0
TLS2_k127_6977839_19 Beta-lactamase class C and other penicillin binding proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008963 317.0
TLS2_k127_6977839_2 Sulfite reductase K00366,K00381,K00392 - 1.7.7.1,1.8.1.2,1.8.7.1 3.274e-284 892.0
TLS2_k127_6977839_20 Uroporphyrin-III C-methyltransferase K02303,K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008885 297.0
TLS2_k127_6977839_21 uroporphyrinogen-III synthase activity K01719,K13542 - 2.1.1.107,4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000159 274.0
TLS2_k127_6977839_22 Amidohydrolase family K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001178 271.0
TLS2_k127_6977839_23 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001607 271.0
TLS2_k127_6977839_24 Serine aminopeptidase, S33 K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003687 254.0
TLS2_k127_6977839_25 Amino-transferase class IV - - - 0.000000000000000000000000000000000000000000000000000000000000000002437 238.0
TLS2_k127_6977839_26 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000003037 239.0
TLS2_k127_6977839_27 HAD-hyrolase-like K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000006286 224.0
TLS2_k127_6977839_28 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000004718 220.0
TLS2_k127_6977839_29 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED K07025 - - 0.000000000000000000000000000000000000000000000000346 186.0
TLS2_k127_6977839_3 PGAP1-like protein - - - 4.736e-278 861.0
TLS2_k127_6977839_30 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000006269 186.0
TLS2_k127_6977839_31 Siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.00000000000000000000000000000000000000000001934 169.0
TLS2_k127_6977839_32 PFAM Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000001041 148.0
TLS2_k127_6977839_33 xaa-pro dipeptidase K01271 K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000001316 148.0
TLS2_k127_6977839_34 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00034,K00038,K00046 - 1.1.1.47,1.1.1.53,1.1.1.69 0.0000000000000000000000000001274 124.0
TLS2_k127_6977839_35 protein conserved in bacteria - - - 0.000000000000000000000000001629 124.0
TLS2_k127_6977839_36 3'-5' exonuclease activity K03547 - - 0.000000000000000000000000005248 119.0
TLS2_k127_6977839_37 Nodulation protein S (NodS) - - - 0.00000000000000000000000001868 117.0
TLS2_k127_6977839_38 TIGRFAM Rrf2 family protein - - - 0.0000000000000000000002557 102.0
TLS2_k127_6977839_39 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000007104 108.0
TLS2_k127_6977839_4 PFAM Prolyl oligopeptidase family - - - 3.063e-274 856.0
TLS2_k127_6977839_40 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.000000000000000000006 104.0
TLS2_k127_6977839_41 carboxylic ester hydrolase activity - - - 0.0000000000000000001341 99.0
TLS2_k127_6977839_42 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K18306 - - 0.0000000000000000001718 97.0
TLS2_k127_6977839_43 - - - - 0.000000000000000001386 96.0
TLS2_k127_6977839_44 - - - - 0.0000000000000001725 86.0
TLS2_k127_6977839_45 Transposase IS200 like - - - 0.0000000000000008793 80.0
TLS2_k127_6977839_46 Iron-binding zinc finger CDGSH type - - - 0.000000000001958 69.0
TLS2_k127_6977839_47 Pfam:Pyridox_oxidase K07006 - - 0.00000000002847 69.0
TLS2_k127_6977839_48 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00000000005522 74.0
TLS2_k127_6977839_49 COG1943 Transposase and inactivated derivatives K07491 - - 0.00000001415 57.0
TLS2_k127_6977839_5 Bacterial protein of unknown function (DUF853) - - - 1.86e-228 715.0
TLS2_k127_6977839_50 Iron-containing redox enzyme K06137 - 1.3.3.11 0.0000006427 59.0
TLS2_k127_6977839_6 DNA topoisomerase VI subunit A K03166 - 5.99.1.3 2.297e-202 634.0
TLS2_k127_6977839_7 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955,K00956 - 2.7.1.25,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003454 576.0
TLS2_k127_6977839_8 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 581.0
TLS2_k127_6977839_9 adenylyltransferase, small subunit K00957 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 507.0
TLS2_k127_7013892_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006295 566.0
TLS2_k127_7013892_1 Phosphomannose isomerase type I K01809,K01840 - 5.3.1.8,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000001341 220.0
TLS2_k127_7013892_2 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.000000000000002734 87.0
TLS2_k127_7032145_0 Regulator of chromosome condensation (RCC1) repeat - - - 1.94e-211 676.0
TLS2_k127_7032145_1 Major Facilitator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 507.0
TLS2_k127_7032145_10 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000003083 186.0
TLS2_k127_7032145_11 MgtC family K07507 - - 0.00000000000000000000000000000000000000005329 154.0
TLS2_k127_7032145_12 AAA domain - - - 0.0000000000000000000000000000000000000001313 156.0
TLS2_k127_7032145_13 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000000001093 150.0
TLS2_k127_7032145_14 Protein of unknown function (DUF1499) - - - 0.0000000000000000000000000000000000003388 147.0
TLS2_k127_7032145_15 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000007078 141.0
TLS2_k127_7032145_16 Adenylate cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000004341 145.0
TLS2_k127_7032145_17 MgtC SapB transporter K07507 - - 0.00000000000000002526 82.0
TLS2_k127_7032145_18 OsmC-like protein - - - 0.00000000001914 68.0
TLS2_k127_7032145_19 GrpB protein - - - 0.00000000002681 72.0
TLS2_k127_7032145_2 DEAD DEAH box helicase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 499.0
TLS2_k127_7032145_20 - - - - 0.000000003988 61.0
TLS2_k127_7032145_21 OsmC-like protein - - - 0.0000001183 56.0
TLS2_k127_7032145_3 Sodium/hydrogen exchanger family K11105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 490.0
TLS2_k127_7032145_4 Zinc-binding dehydrogenase K00001,K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 361.0
TLS2_k127_7032145_5 Histidine kinase K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003723 301.0
TLS2_k127_7032145_6 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000007641 209.0
TLS2_k127_7032145_7 Glycerophosphoryl diester phosphodiesterase family K01113,K01126 - 3.1.3.1,3.1.4.46 0.000000000000000000000000000000000000000000000000000001585 211.0
TLS2_k127_7032145_8 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000000000002283 187.0
TLS2_k127_7032145_9 Sulfite exporter TauE/SafE - - - 0.0000000000000000000000000000000000000000000000004775 184.0
TLS2_k127_7045894_0 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000004296 232.0
TLS2_k127_7045894_1 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000004526 222.0
TLS2_k127_7045894_2 - K06039 - - 0.0000000000000821 74.0
TLS2_k127_7053444_0 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008375 590.0
TLS2_k127_7053444_1 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004728 565.0
TLS2_k127_7053444_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K05580 - 1.6.5.3 0.000000000000000000000000000000000000000000000002712 180.0
TLS2_k127_7053444_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00330 - 1.6.5.3 0.0000000000000000000000000000000000000008034 151.0
TLS2_k127_7053444_12 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000000000000000004515 145.0
TLS2_k127_7053444_13 intermembrane phospholipid transfer K07323 - - 0.000000000000000000000000000000000002872 145.0
TLS2_k127_7053444_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000008282 129.0
TLS2_k127_7053444_15 NMT1-like family - - - 0.000000000000000001974 96.0
TLS2_k127_7053444_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006679 471.0
TLS2_k127_7053444_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009178 414.0
TLS2_k127_7053444_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 397.0
TLS2_k127_7053444_5 Transketolase, pyrimidine binding domain K21417 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 326.0
TLS2_k127_7053444_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K21416 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007499 295.0
TLS2_k127_7053444_7 Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001099 254.0
TLS2_k127_7053444_8 Alpha/beta hydrolase of unknown function (DUF1100) - - - 0.00000000000000000000000000000000000000000000000000002081 198.0
TLS2_k127_7053444_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000005974 188.0
TLS2_k127_7071446_0 transport system fused permease components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 502.0
TLS2_k127_7071446_1 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000001851 215.0
TLS2_k127_7071446_2 TRAP transporter solute receptor TAXI family protein K07080 - - 0.0000000000000000000000000000000000000008966 161.0
TLS2_k127_7075993_0 Domain of unknown function (DUF4143) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007964 490.0
TLS2_k127_7075993_1 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955,K00956 - 2.7.1.25,2.7.7.4 0.00000000000000000000000000000000000000000000000000000000007829 205.0
TLS2_k127_7075993_2 nucleotidyltransferase activity K07075,K07076 - - 0.000000000000000000000000000000000000000000000000000522 191.0
TLS2_k127_7075993_3 HEPN domain K07076 - - 0.0000000000000000000000000000008862 123.0
TLS2_k127_7085843_0 Glycosyl hydrolases family 15 - - - 7.034e-268 839.0
TLS2_k127_7085843_1 protein-containing complex disassembly K02837,K07133 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 3.365e-209 664.0
TLS2_k127_7085843_10 Catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006277 289.0
TLS2_k127_7085843_11 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005911 269.0
TLS2_k127_7085843_12 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000009593 221.0
TLS2_k127_7085843_13 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000001164 167.0
TLS2_k127_7085843_14 - - - - 0.000000000000000000000000000000000000000007979 160.0
TLS2_k127_7085843_15 Cupin domain - - - 0.000000000000000000000000000000000000006344 153.0
TLS2_k127_7085843_16 Cysteine dioxygenase type I K00456 - 1.13.11.20 0.0000000000000000000000000005485 119.0
TLS2_k127_7085843_18 - - - - 0.0000000001466 67.0
TLS2_k127_7085843_19 Tripartite tricarboxylate transporter family receptor - - - 0.00000001394 66.0
TLS2_k127_7085843_2 Ion channel - - - 9.062e-197 629.0
TLS2_k127_7085843_20 NMT1-like family K02051 - - 0.00000003872 62.0
TLS2_k127_7085843_21 Cupin 2, conserved barrel domain protein - - - 0.0002089 49.0
TLS2_k127_7085843_3 Tripartite tricarboxylate transporter TctA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004013 560.0
TLS2_k127_7085843_4 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007367 532.0
TLS2_k127_7085843_5 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 424.0
TLS2_k127_7085843_6 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 400.0
TLS2_k127_7085843_7 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000636 372.0
TLS2_k127_7085843_8 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005744 320.0
TLS2_k127_7085843_9 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 310.0
TLS2_k127_7131684_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 406.0
TLS2_k127_7131684_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000005771 177.0
TLS2_k127_7131684_2 Catalase K03781 - 1.11.1.6 0.00000000000000000000000000000001373 130.0
TLS2_k127_7136634_0 Tripartite tricarboxylate transporter TctA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 350.0
TLS2_k127_7212623_0 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 1.018e-291 901.0
TLS2_k127_7212623_1 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 343.0
TLS2_k127_7212623_2 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008611 305.0
TLS2_k127_7212623_3 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004958 292.0
TLS2_k127_7212623_4 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000001459 229.0
TLS2_k127_7212623_5 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000006514 200.0
TLS2_k127_7212623_6 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000001194 139.0
TLS2_k127_7212623_7 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.0000000001378 73.0
TLS2_k127_7262929_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006985 330.0
TLS2_k127_7262929_1 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006308 299.0
TLS2_k127_7262929_2 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000113 186.0
TLS2_k127_7262929_3 PFAM luciferase-like - - - 0.000000000000000000000000000000000000000000000008803 184.0
TLS2_k127_7262929_4 Helix-turn-helix domain, rpiR family - - - 0.00000000000000000000000000000000000005808 153.0
TLS2_k127_7262929_5 - - - - 0.0000000000000000000000000142 115.0
TLS2_k127_7271860_0 Domain of unknown function (DUF4202) - - - 0.00000000000000000000000000000000000000000000000000000001973 203.0
TLS2_k127_7271860_1 thiolester hydrolase activity K06889 - - 0.000000000000000000000000000000000000000000000000000133 196.0
TLS2_k127_730657_0 AAA domain K07133 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 345.0
TLS2_k127_730657_1 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 316.0
TLS2_k127_730657_2 thiamine-containing compound biosynthetic process K02051,K15551,K15556 - - 0.000000000000000000000000000000000000000001688 168.0
TLS2_k127_730657_3 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000002804 152.0
TLS2_k127_730657_4 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000001994 130.0
TLS2_k127_7382082_0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007378 465.0
TLS2_k127_7382082_1 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 454.0
TLS2_k127_7382082_10 Haem-degrading K11477 - - 0.0000000000000003035 86.0
TLS2_k127_7382082_11 Coenzyme A transferase K01040 - 2.8.3.12 0.0000000005971 63.0
TLS2_k127_7382082_2 ABC-type Fe3 transport system permease component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 431.0
TLS2_k127_7382082_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 293.0
TLS2_k127_7382082_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001828 280.0
TLS2_k127_7382082_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005494 270.0
TLS2_k127_7382082_6 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000005068 223.0
TLS2_k127_7382082_7 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000001645 160.0
TLS2_k127_7382082_8 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000008748 127.0
TLS2_k127_7382082_9 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000004411 118.0
TLS2_k127_7457813_0 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000437 389.0
TLS2_k127_755934_0 acetyl-coa acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 345.0
TLS2_k127_755934_1 Transposase IS200 like K07491 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001935 265.0
TLS2_k127_755934_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008813 253.0
TLS2_k127_755934_3 Sir2 family K12410 - - 0.0000000000000000000000000000000000000000000000001053 185.0
TLS2_k127_755934_4 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.00000000000000000000000000000000000005581 155.0
TLS2_k127_755934_5 FKBP-type peptidyl-prolyl cis-trans isomerase K03775 - 5.2.1.8 0.000000000000000000000000000000000002597 147.0
TLS2_k127_755934_6 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.0000000000000000000000000000000000938 138.0
TLS2_k127_755934_7 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000001297 140.0
TLS2_k127_755934_8 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.000000001145 69.0
TLS2_k127_755934_9 PFAM EamA-like transporter family - - - 0.0004763 51.0
TLS2_k127_78661_0 Belongs to the aconitase IPM isomerase family K01703 - 4.2.1.33,4.2.1.35 2.44e-205 650.0
TLS2_k127_78661_1 WYL domain K13572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006631 422.0
TLS2_k127_78661_3 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000004259 166.0
TLS2_k127_78661_4 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000001341 112.0
TLS2_k127_78908_0 ATP-grasp domain K01905,K22224 - 6.2.1.13 5.744e-318 997.0
TLS2_k127_78908_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 2.797e-313 972.0
TLS2_k127_78908_10 PFAM ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 308.0
TLS2_k127_78908_11 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000848 310.0
TLS2_k127_78908_12 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 298.0
TLS2_k127_78908_13 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002188 275.0
TLS2_k127_78908_14 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000006219 254.0
TLS2_k127_78908_15 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000162 256.0
TLS2_k127_78908_16 Phosphoribosyl transferase domain K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000001179 216.0
TLS2_k127_78908_17 Lysin motif K06194 - - 0.000000000000000000000000000000000000000000000004368 188.0
TLS2_k127_78908_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000001324 166.0
TLS2_k127_78908_19 Sulphur transport K07112 - - 0.0000000000000000000000005813 108.0
TLS2_k127_78908_2 Pyridine nucleotide-disulphide oxidoreductase - - - 1.955e-220 698.0
TLS2_k127_78908_20 Ferritin-like domain - - - 0.000000000000001303 77.0
TLS2_k127_78908_21 His Kinase A (phosphoacceptor) domain - - - 0.0000000000001183 76.0
TLS2_k127_78908_22 5-oxoproline from various penultimate amino acid residues except L-proline K01304 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:1901564 3.4.19.3 0.000006614 56.0
TLS2_k127_78908_23 PFAM beta-lactamase domain protein - - - 0.000008878 51.0
TLS2_k127_78908_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 532.0
TLS2_k127_78908_4 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 476.0
TLS2_k127_78908_5 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 399.0
TLS2_k127_78908_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 391.0
TLS2_k127_78908_7 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 378.0
TLS2_k127_78908_8 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K21025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004071 353.0
TLS2_k127_78908_9 Outer membrane lipoprotein-sorting protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 317.0
TLS2_k127_792213_0 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 336.0
TLS2_k127_792213_1 Family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000000000001101 228.0
TLS2_k127_80884_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01576,K01652 - 2.2.1.6,4.1.1.7 5.016e-219 696.0
TLS2_k127_80884_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 477.0
TLS2_k127_80884_2 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 300.0
TLS2_k127_80884_3 Zn-dependent alcohol dehydrogenases K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 299.0
TLS2_k127_80884_4 ADP-glyceromanno-heptose 6-epimerase activity K01709,K01784,K22025 - 1.1.1.410,4.2.1.45,5.1.3.2 0.000000000000000000000000000000000000000000000000000000000002532 222.0
TLS2_k127_80884_5 Serine aminopeptidase, S33 K06889 - - 0.0000000000000000000000000000000000000000000000003223 186.0
TLS2_k127_80884_6 carboxymuconolactone decarboxylase - - - 0.0000000000000001963 86.0
TLS2_k127_80884_7 Glutathione transferase K21253,K21264,K21265 - 2.5.1.18 0.000007404 55.0
TLS2_k127_818929_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 6.32e-231 732.0
TLS2_k127_818929_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004261 366.0
TLS2_k127_818929_2 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067,K01790 - 1.1.1.133,5.1.3.13 0.0000000000000000000000000000000000000007779 157.0
TLS2_k127_818929_3 - - - - 0.000000000000000000000000000000000000004502 160.0
TLS2_k127_818929_4 Met-10+ like-protein - - - 0.00000000000000000000000000000000000001839 151.0
TLS2_k127_818929_5 response regulator K02481 - - 0.00000000000000000003079 103.0
TLS2_k127_818929_6 Protein of unknown function (DUF3108) - - - 0.00000000000002583 83.0
TLS2_k127_818929_7 peptidase M48, Ste24p - - - 0.0000000000009878 78.0
TLS2_k127_82315_0 Binding-protein-dependent transport system inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 364.0
TLS2_k127_82315_1 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 349.0
TLS2_k127_82315_10 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000276 156.0
TLS2_k127_82315_11 amine dehydrogenase activity - - - 0.000000000000000000000000000000000397 141.0
TLS2_k127_82315_12 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000001989 130.0
TLS2_k127_82315_13 ABC-type nitrate sulfonate bicarbonate transport - - - 0.0000000000000000000006501 106.0
TLS2_k127_82315_14 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000006891 99.0
TLS2_k127_82315_15 peptidase M48, Ste24p - - - 0.000000000000000008888 93.0
TLS2_k127_82315_16 Peptidase dimerisation domain K12941 - - 0.0000000000001888 71.0
TLS2_k127_82315_2 COG0604 NADPH quinone reductase and related Zn-dependent K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005067 339.0
TLS2_k127_82315_3 Amidohydrolase K10220 - 4.2.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 332.0
TLS2_k127_82315_4 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008352 313.0
TLS2_k127_82315_5 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001601 233.0
TLS2_k127_82315_6 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000001433 205.0
TLS2_k127_82315_7 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000003391 198.0
TLS2_k127_82315_8 Extradiol ring-cleavage dioxygenase K04101,K05713 - 1.13.11.16,1.13.11.8 0.00000000000000000000000000000000000000000000000009225 183.0
TLS2_k127_82315_9 Protein of unknown function (DUF541) K09807 - - 0.0000000000000000000000000000000000000000001345 168.0
TLS2_k127_905504_0 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00479,K05708,K14748 - 1.14.12.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006289 378.0
TLS2_k127_905504_1 Selenoprotein B, glycine betaine sarcosine D-proline reductase family K10672 - 1.21.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 349.0
TLS2_k127_905504_10 Transposase IS200 like - - - 0.00000065 51.0
TLS2_k127_905504_2 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000001614 257.0
TLS2_k127_905504_3 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000002621 240.0
TLS2_k127_905504_4 PFAM Glycine sarcosine betaine reductase complex, protein B, alpha and beta subunits K10671 - 1.21.4.2 0.00000000000000000000000000000000000000000000000000005093 203.0
TLS2_k127_905504_5 COGs COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000005106 191.0
TLS2_k127_905504_6 Ring hydroxylating beta subunit - - - 0.00000000000000000000000000000000000000000000002695 175.0
TLS2_k127_905504_7 Transposase IS200 like - - - 0.00000000000000000000000000004063 119.0
TLS2_k127_905504_8 Transposase IS200 like - - - 0.00000000000005211 74.0
TLS2_k127_905504_9 Selenoprotein B glycine betaine sarcosine D-proline reductase - - - 0.0000000008591 62.0
TLS2_k127_938160_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 398.0
TLS2_k127_938160_1 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000000000000000000000000000000000000000000000000000000002571 241.0
TLS2_k127_938160_2 NADPH-dependent FMN reductase K19784 - - 0.0000000000000000000000000000000000000000000000000000000000004517 215.0
TLS2_k127_938160_3 acetylesterase activity K01046 - 3.1.1.3 0.0000000000000000000000000000000000000000000000000000001875 206.0
TLS2_k127_938160_4 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000004145 203.0
TLS2_k127_938160_5 protein related to plant photosystem II stability assembly factor - - - 0.000000000000000000000000000000000000000000000000001585 190.0
TLS2_k127_938160_6 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.000000000000000000000000000991 118.0
TLS2_k127_938160_7 hydroperoxide reductase activity K07486 - - 0.00000415 51.0
TLS2_k127_938160_8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0002187 46.0
TLS2_k127_978782_0 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.0 1750.0
TLS2_k127_978782_1 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 602.0
TLS2_k127_978782_10 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000001138 153.0
TLS2_k127_978782_11 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000141 151.0
TLS2_k127_978782_12 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000005764 140.0
TLS2_k127_978782_13 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000005344 136.0
TLS2_k127_978782_14 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000000000003117 122.0
TLS2_k127_978782_15 Bacterial transferase hexapeptide (six repeats) K00627,K06889,K13006 - 2.3.1.12 0.000000000000287 73.0
TLS2_k127_978782_16 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000007335 76.0
TLS2_k127_978782_2 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 535.0
TLS2_k127_978782_3 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 401.0
TLS2_k127_978782_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005062 371.0
TLS2_k127_978782_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 308.0
TLS2_k127_978782_6 Cytidylyltransferase-like K00969 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 0.000000000000000000000000000000000000000000000000000000000007496 216.0
TLS2_k127_978782_7 PFAM Phosphoribosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000001181 216.0
TLS2_k127_978782_8 DTW K05812 - - 0.0000000000000000000000000000000000000000000000000002067 193.0
TLS2_k127_978782_9 regulatory protein, arsR - - - 0.000000000000000000000000000000000000000000004575 176.0
TLS2_k127_991642_0 Binding-protein-dependent transport system inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 443.0
TLS2_k127_991642_1 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009891 245.0
TLS2_k127_991642_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000003975 221.0
TLS2_k127_991642_3 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000002248 199.0
TLS2_k127_991642_4 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000004032 176.0
TLS2_k127_991642_5 iron ion homeostasis K02012 - - 0.000000000000000000000000000000000000000002386 169.0
TLS2_k127_991642_6 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain K04940 - 1.5.1.28 0.00000000000000000000000000000004617 130.0
TLS2_k127_991642_7 TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase K01439 - 3.5.1.18 0.0000000000000000000000006249 118.0
TLS2_k127_991642_8 Diguanylate cyclase K21023 - 2.7.7.65 0.00000000001411 69.0