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Overview

ID MAG04000
Name TLS2_bin.34
Sample SMP0104
Taxonomy
Kingdom Archaea
Phylum Thermoproteota
Class Nitrososphaeria
Order Nitrososphaerales
Family Nitrososphaeraceae
Genus Nitrososphaera
Species Nitrososphaera sp036741615
Assembly information
Completeness (%) 85.17
Contamination (%) 0.14
GC content (%) 42.0
N50 (bp) 10,512
Genome size (bp) 1,772,670

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1562

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1002879_0 Peptidase family M3 K08602 - - 9.309e-273 852.0
TLS2_k127_1002879_1 PFAM Alcohol dehydrogenase GroES-like domain - - - 1.416e-212 662.0
TLS2_k127_1002879_10 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.0000000000000000000000000000001959 125.0
TLS2_k127_1002879_11 Domain of unknown function (DUF892) - - - 0.00000002713 64.0
TLS2_k127_1002879_2 Cysteine desulfurase K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 582.0
TLS2_k127_1002879_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 501.0
TLS2_k127_1002879_4 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005772 423.0
TLS2_k127_1002879_5 Na -dependent transporter K03453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007817 331.0
TLS2_k127_1002879_6 Lrp/AsnC ligand binding domain K03718 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003207 271.0
TLS2_k127_1002879_7 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001293 256.0
TLS2_k127_1002879_8 Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA K14568 - 2.1.1.260 0.00000000000000000000000000000000000000000000000000000000000002903 222.0
TLS2_k127_1002879_9 Belongs to the PDCD5 family K06875 - - 0.000000000000000000000000000000000000002475 149.0
TLS2_k127_1114211_1 Universal stress protein - - - 0.00000000000000000000000000000000004891 138.0
TLS2_k127_1114211_2 - - - - 0.000000000000000000000003485 106.0
TLS2_k127_114913_0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.0000000000000000000000000000000000000000007154 164.0
TLS2_k127_1174893_0 PFAM 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000396 143.0
TLS2_k127_1174893_1 Predicted membrane protein (DUF2254) - - - 0.00000000000002201 86.0
TLS2_k127_120956_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 1.47e-224 705.0
TLS2_k127_121462_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 374.0
TLS2_k127_121462_1 Lamin Tail Domain - - - 0.00000000000000000000000000000000000000000000000000000003508 212.0
TLS2_k127_121462_2 Poly(Beta-D-mannuronate) C5 epimerase K01795 - 5.1.3.37 0.000005899 59.0
TLS2_k127_133767_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1098.0
TLS2_k127_133767_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 9.676e-264 817.0
TLS2_k127_133767_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 387.0
TLS2_k127_133767_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000000000000000000000009516 226.0
TLS2_k127_133767_4 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000000000000000000000008844 204.0
TLS2_k127_133767_5 - - - - 0.00000000000000000000000000000000000000008785 153.0
TLS2_k127_133767_6 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000699 140.0
TLS2_k127_133767_7 - - - - 0.000000000000000000000000000000001437 132.0
TLS2_k127_1371529_0 CBS domain K03498 - - 2.043e-274 858.0
TLS2_k127_1371529_1 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003681 240.0
TLS2_k127_1371529_2 Nitroreductase family - - - 0.000000000000000000002643 96.0
TLS2_k127_1371529_3 - - - - 0.00002739 58.0
TLS2_k127_1394219_0 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 512.0
TLS2_k127_1394219_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 506.0
TLS2_k127_1394219_10 PhoU domain K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 324.0
TLS2_k127_1394219_11 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008183 289.0
TLS2_k127_1394219_12 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002794 248.0
TLS2_k127_1394219_13 ribosomal protein K02907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000297 243.0
TLS2_k127_1394219_14 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000007491 140.0
TLS2_k127_1394219_2 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 471.0
TLS2_k127_1394219_3 TIGRFAM phosphate ABC transporter K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007279 462.0
TLS2_k127_1394219_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005865 428.0
TLS2_k127_1394219_5 tRNA methyl transferase K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000933 398.0
TLS2_k127_1394219_6 TIGRFAM phosphate ABC transporter K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 398.0
TLS2_k127_1394219_7 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 417.0
TLS2_k127_1394219_8 Belongs to the universal ribosomal protein uS5 family K02988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 372.0
TLS2_k127_1394219_9 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 356.0
TLS2_k127_1494666_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 312.0
TLS2_k127_1494666_1 Winged helix-turn-helix - - - 0.00000000003845 66.0
TLS2_k127_14978_0 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 515.0
TLS2_k127_14978_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 454.0
TLS2_k127_14978_2 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 358.0
TLS2_k127_14978_3 - - - - 0.00000000000000000000000000004244 119.0
TLS2_k127_14978_4 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.00000000001201 67.0
TLS2_k127_14978_5 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.0000000001335 64.0
TLS2_k127_150106_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 - - 9.529e-259 801.0
TLS2_k127_150106_1 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 1.217e-216 677.0
TLS2_k127_150106_2 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009713 463.0
TLS2_k127_150106_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000001459 206.0
TLS2_k127_150106_4 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000000003728 196.0
TLS2_k127_150106_5 - - - - 0.0000000000000000000000000000000000000000000004793 175.0
TLS2_k127_150106_6 serine-type endopeptidase activity - - - 0.0000000000000000000000000000000000966 139.0
TLS2_k127_150106_7 resistance protein K14166 - - 0.000000000000000000000000000000003096 131.0
TLS2_k127_150106_8 copper ion binding - - - 0.00000000009662 70.0
TLS2_k127_1531403_0 TIGRFAM phosphate ABC transporter K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 409.0
TLS2_k127_1531403_1 uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005275 317.0
TLS2_k127_1531403_2 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000241 224.0
TLS2_k127_1531403_3 Belongs to the UPF0284 family - - - 0.00000000000000000000000000000000000000000001239 167.0
TLS2_k127_1552396_0 Vinylacetyl-CoA Delta-isomerase K14534 - 4.2.1.120,5.3.3.3 1.256e-281 870.0
TLS2_k127_1552396_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 563.0
TLS2_k127_1552396_10 - - - - 0.00000000000000000000000000000000000000000000009703 172.0
TLS2_k127_1552396_11 Bacterial Fe(2+) trafficking - - - 0.00000000000000000000000000000000000000003395 153.0
TLS2_k127_1552396_13 - - - - 0.00000000000000000000001051 101.0
TLS2_k127_1552396_14 - - - - 0.00000000000000000008562 90.0
TLS2_k127_1552396_15 response regulator, receiver - - - 0.0000000000000000002917 93.0
TLS2_k127_1552396_18 Transcriptional regulator - - - 0.0000398 49.0
TLS2_k127_1552396_2 Domain of unknown function (DUF373) K08975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009919 555.0
TLS2_k127_1552396_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 328.0
TLS2_k127_1552396_4 Chlorophyllase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000002033 272.0
TLS2_k127_1552396_5 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000005222 265.0
TLS2_k127_1552396_7 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000000000000000000000000000000000000002682 218.0
TLS2_k127_1552396_8 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000002734 203.0
TLS2_k127_1552396_9 Orotidine 5'-phosphate decarboxylase / HUMPS family K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000003421 204.0
TLS2_k127_1590941_0 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 587.0
TLS2_k127_1590941_1 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000574 480.0
TLS2_k127_1590941_10 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000003452 111.0
TLS2_k127_1590941_11 OsmC-like protein - - - 0.0001674 47.0
TLS2_k127_1590941_2 PFAM 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 351.0
TLS2_k127_1590941_3 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 341.0
TLS2_k127_1590941_4 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001035 259.0
TLS2_k127_1590941_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000006887 224.0
TLS2_k127_1590941_6 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000000000007912 211.0
TLS2_k127_1590941_7 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000003951 170.0
TLS2_k127_1590941_8 NMT1/THI5 like K15598 - - 0.000000000000000000000000000000000000000001361 168.0
TLS2_k127_1590941_9 Methyltransferase domain - - - 0.00000000000000000000000000000000000000003356 162.0
TLS2_k127_1624890_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01867 - 6.1.1.2 2.979e-222 692.0
TLS2_k127_1624890_1 - - - - 0.00000000000000000000000000000000000000000000000000004319 189.0
TLS2_k127_1624890_2 Phenylalanyl-tRNA synthetase alpha subunit K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000006226 168.0
TLS2_k127_1624890_3 - - - - 0.00000000000000000000000006402 109.0
TLS2_k127_1635255_0 COG2133 Glucose sorbosone dehydrogenases - - - 4.334e-225 707.0
TLS2_k127_1635255_1 sequence-specific DNA binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 389.0
TLS2_k127_1635255_3 PFAM Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000005923 55.0
TLS2_k127_1644818_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 561.0
TLS2_k127_1644818_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 396.0
TLS2_k127_1644818_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0001838,GO:0001841,GO:0001843,GO:0002009,GO:0002237,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006979,GO:0007275,GO:0007399,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009605,GO:0009607,GO:0009617,GO:0009653,GO:0009790,GO:0009792,GO:0009888,GO:0009987,GO:0010033,GO:0010467,GO:0014020,GO:0016053,GO:0016331,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0021915,GO:0031974,GO:0032496,GO:0032501,GO:0032502,GO:0032787,GO:0033993,GO:0034641,GO:0035148,GO:0035239,GO:0035295,GO:0036211,GO:0042221,GO:0043009,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0048598,GO:0048646,GO:0048729,GO:0048731,GO:0048856,GO:0050896,GO:0051186,GO:0051188,GO:0051604,GO:0051704,GO:0051707,GO:0060429,GO:0060562,GO:0060606,GO:0070013,GO:0070283,GO:0071704,GO:0072175,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901700 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009487 364.0
TLS2_k127_1644818_3 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008686 351.0
TLS2_k127_1644818_4 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 287.0
TLS2_k127_1644818_5 pyridine nucleotide-disulphide oxidoreductase dimerisation K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000001021 271.0
TLS2_k127_1644818_6 Lipoate-protein ligase K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000000000000000000000000000003416 243.0
TLS2_k127_1644818_7 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000002676 138.0
TLS2_k127_1644818_8 lipoate-protein ligase A - - - 0.00000004968 57.0
TLS2_k127_1658800_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0050897,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.17.19 1.229e-284 878.0
TLS2_k127_1658800_1 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 453.0
TLS2_k127_1658800_10 - - - - 0.000004109 53.0
TLS2_k127_1658800_2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000001969 259.0
TLS2_k127_1658800_3 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000001141 200.0
TLS2_k127_1658800_5 Cupin - - - 0.00000000000000000000000000000000007753 138.0
TLS2_k127_1658800_6 - - - - 0.0000000000000000000000000000009147 124.0
TLS2_k127_1658800_7 - - - - 0.000000000000000000009368 94.0
TLS2_k127_1658800_8 - - - - 0.000000000000000005059 90.0
TLS2_k127_1658800_9 Uncharacterized conserved protein (DUF2196) - - - 0.0000000000000001038 81.0
TLS2_k127_1679366_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 604.0
TLS2_k127_1679366_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 588.0
TLS2_k127_1679366_10 COG1522 Transcriptional regulators - - - 0.00001602 51.0
TLS2_k127_1679366_11 C2H2-type zinc finger - GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044212,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0002817 44.0
TLS2_k127_1679366_2 Chorismate mutase type II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007629 585.0
TLS2_k127_1679366_3 DNA methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 510.0
TLS2_k127_1679366_4 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 394.0
TLS2_k127_1679366_5 GHMP kinases N terminal domain K00891 - 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000088 367.0
TLS2_k127_1679366_6 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 308.0
TLS2_k127_1679366_7 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000003313 268.0
TLS2_k127_1679366_8 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000003925 259.0
TLS2_k127_1681033_0 phosphohydrolase (DHH superfamily) K07097 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 436.0
TLS2_k127_1681033_1 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 395.0
TLS2_k127_1681033_2 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000000000000000007733 202.0
TLS2_k127_171176_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 549.0
TLS2_k127_171176_1 COG1522 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 548.0
TLS2_k127_171176_2 FeS assembly ATPase SufC K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003088 468.0
TLS2_k127_171176_3 Chlorite dismutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 389.0
TLS2_k127_171176_4 Domain of unknown function (DUF1802) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001299 269.0
TLS2_k127_171176_5 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003692 251.0
TLS2_k127_171176_6 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000003702 98.0
TLS2_k127_1730917_0 Anticodon-binding domain of tRNA K01873 - 6.1.1.9 0.0 1299.0
TLS2_k127_1730917_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 3.622e-274 851.0
TLS2_k127_1730917_2 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 433.0
TLS2_k127_1730917_3 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003999 349.0
TLS2_k127_1730917_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001238 237.0
TLS2_k127_1730917_5 - - - - 0.000000000000000000000000000000000000000000000003003 175.0
TLS2_k127_1730917_6 Restriction endonuclease - - - 0.0000000000000000000000006201 113.0
TLS2_k127_1730917_7 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.000000000000000000000001154 106.0
TLS2_k127_1738647_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 561.0
TLS2_k127_1738647_1 PFAM TrkA-C domain protein - - - 0.00000000000000000000000000000000000000000000000000000001709 213.0
TLS2_k127_1738647_2 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000002235 179.0
TLS2_k127_1738647_3 to cation transporters K07244 - - 0.000000000000000000000000000000000002751 147.0
TLS2_k127_1738647_4 to cation transporters K07244 - - 0.000000000000000000000000000000007892 135.0
TLS2_k127_1738647_5 Universal stress protein family - - - 0.000000000000000001032 91.0
TLS2_k127_1752447_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000007444 208.0
TLS2_k127_1752447_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000849 161.0
TLS2_k127_1752447_2 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.0000000000000000000000000000000000003895 141.0
TLS2_k127_1752447_3 amino acid activation for nonribosomal peptide biosynthetic process K01070,K07214 - 3.1.2.12 0.00003401 48.0
TLS2_k127_1752447_4 Protein of unknown function, DUF393 - - - 0.0002323 49.0
TLS2_k127_178565_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 1.178e-259 814.0
TLS2_k127_178565_1 tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 447.0
TLS2_k127_178565_2 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 399.0
TLS2_k127_178565_3 Phosphoglycolate phosphatase K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 389.0
TLS2_k127_178565_4 cytochrome-c peroxidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003681 278.0
TLS2_k127_178565_5 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007243 250.0
TLS2_k127_178565_7 - - - - 0.00000000000000000000000000005874 123.0
TLS2_k127_178565_8 - - - - 0.000000000000001657 79.0
TLS2_k127_178565_9 Protein of unknown function DUF72 - - - 0.00007105 46.0
TLS2_k127_1933966_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 6.512e-196 619.0
TLS2_k127_1933966_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 554.0
TLS2_k127_1933966_10 ATP corrinoid adenosyltransferase K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004349 290.0
TLS2_k127_1933966_11 AMMECR1 K09141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002036 269.0
TLS2_k127_1933966_12 Precorrin-8X methylmutase K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000000000000000006076 238.0
TLS2_k127_1933966_13 - - - - 0.000000000000000000000000000000000000000000000000000000003545 201.0
TLS2_k127_1933966_14 COG0346 Lactoylglutathione lyase and related lyases - - - 0.0000000000000000000000000000000000000000000561 164.0
TLS2_k127_1933966_15 - - - - 0.00000000000000000000000000000000000000003084 153.0
TLS2_k127_1933966_16 - - - - 0.0000000000000000000000000000000000004303 140.0
TLS2_k127_1933966_17 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000000000000002673 94.0
TLS2_k127_1933966_18 - - - - 0.00000000000000000002316 94.0
TLS2_k127_1933966_2 Glycosyl transferase family 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 546.0
TLS2_k127_1933966_20 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000008476 68.0
TLS2_k127_1933966_21 Translation initiation factor 2, alpha subunit K03237 - - 0.000000001856 61.0
TLS2_k127_1933966_3 Cobalamin synthesis G C-terminus K02189 - 3.7.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 538.0
TLS2_k127_1933966_4 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003544 528.0
TLS2_k127_1933966_5 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008946 483.0
TLS2_k127_1933966_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 436.0
TLS2_k127_1933966_7 Cobalt chelatase (CbiK) K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 373.0
TLS2_k127_1933966_8 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 335.0
TLS2_k127_1933966_9 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 298.0
TLS2_k127_1935267_0 Type III restriction enzyme, res subunit - - - 8.137e-207 654.0
TLS2_k127_1935267_1 Proteasome endopeptidase complex K03432 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004746 349.0
TLS2_k127_1935267_2 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000002087 178.0
TLS2_k127_1935267_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000003804 105.0
TLS2_k127_1935267_4 Protein of unknown function (DUF790) K09744 - - 0.0003641 43.0
TLS2_k127_195720_1 Circadian clock protein KaiC - - - 0.0000000000000000000000003732 112.0
TLS2_k127_195720_2 PFAM blue (type 1) copper domain protein - - - 0.0000000000000005383 89.0
TLS2_k127_195720_3 - - - - 0.00000000000001009 80.0
TLS2_k127_195720_4 response regulator, receiver - - - 0.0000000000001302 81.0
TLS2_k127_195720_5 - - - - 0.0000000000004906 74.0
TLS2_k127_200254_0 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 1.155e-318 991.0
TLS2_k127_200254_1 PFAM TCP-1 cpn60 chaperonin family K22447 - - 3.313e-274 851.0
TLS2_k127_200254_2 PFAM TCP-1 cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 6.853e-233 728.0
TLS2_k127_200254_3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03190 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 436.0
TLS2_k127_200254_4 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009817 390.0
TLS2_k127_200254_5 UreF K03188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005057 305.0
TLS2_k127_200254_6 Urease, alpha subunit K01428 - 3.5.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000003485 259.0
TLS2_k127_200254_7 UreE urease accessory protein, N-terminal domain K03187 - - 0.0000000000000000000000000000000000000000000000000000000000004773 214.0
TLS2_k127_2008140_0 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004061 475.0
TLS2_k127_2008140_1 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 387.0
TLS2_k127_2008140_2 Phosphate uptake regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002204 241.0
TLS2_k127_2008140_3 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.000000000000000000000000000000000000000000000000000000000000405 224.0
TLS2_k127_2008140_4 - - - - 0.0000000000000000000000000000000000000000000000000000003986 198.0
TLS2_k127_2057708_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.0 1206.0
TLS2_k127_2057708_1 antibiotic catabolic process K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009171 554.0
TLS2_k127_2057708_10 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.000000000000000000000000000000002635 128.0
TLS2_k127_2057708_11 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.000000000000000000000000000000003953 130.0
TLS2_k127_2057708_13 - - - - 0.000000000000000000000000000002936 121.0
TLS2_k127_2057708_2 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 516.0
TLS2_k127_2057708_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 482.0
TLS2_k127_2057708_4 cation diffusion facilitator family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 400.0
TLS2_k127_2057708_5 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 356.0
TLS2_k127_2057708_6 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 338.0
TLS2_k127_2057708_7 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 320.0
TLS2_k127_2057708_8 Peptidyl-tRNA hydrolase PTH2 K04794 - 3.1.1.29 0.000000000000000000000000000000000000000000000001265 176.0
TLS2_k127_2057708_9 zinc finger - - - 0.000000000000000000000000000000000022 140.0
TLS2_k127_2079337_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 2.102e-279 868.0
TLS2_k127_2079337_1 Radical SAM - - - 5.183e-238 737.0
TLS2_k127_2079337_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006024 355.0
TLS2_k127_2079337_11 Amino acid kinase family K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 342.0
TLS2_k127_2079337_12 phosphoribosyltransferases K04096,K07100 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006862 271.0
TLS2_k127_2079337_13 Ribosome biogenesis protein, C-terminal K09140 - - 0.00000000000000000000000000000000000000000000000000000000000000000001647 238.0
TLS2_k127_2079337_14 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000001457 233.0
TLS2_k127_2079337_15 integrase family - - - 0.0000000000000000000000000000000000000000000000000000000002041 218.0
TLS2_k127_2079337_16 - - - - 0.0000000000000000000000000000000000000000000000005239 176.0
TLS2_k127_2079337_18 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.000000000000000000000001561 102.0
TLS2_k127_2079337_19 - - - - 0.00004161 55.0
TLS2_k127_2079337_2 3-hydroxyacyl-CoA dehydrogenase K15016 - 1.1.1.35,4.2.1.17 3.672e-204 640.0
TLS2_k127_2079337_3 Type III restriction enzyme, res subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000479 600.0
TLS2_k127_2079337_4 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 581.0
TLS2_k127_2079337_5 oxidoreductase FAD NAD(P)-binding K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003926 518.0
TLS2_k127_2079337_6 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 476.0
TLS2_k127_2079337_7 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 469.0
TLS2_k127_2079337_8 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 465.0
TLS2_k127_2079337_9 DNA methylase K00590 - 2.1.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 430.0
TLS2_k127_2100750_0 MGS-like domain K01955 - 6.3.5.5 0.0 1707.0
TLS2_k127_2100750_1 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.0 1005.0
TLS2_k127_2100750_10 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 539.0
TLS2_k127_2100750_11 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 490.0
TLS2_k127_2100750_12 Belongs to the enoyl-CoA hydratase isomerase family K01715,K15019 - 4.2.1.116,4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 481.0
TLS2_k127_2100750_13 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 460.0
TLS2_k127_2100750_14 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009645 428.0
TLS2_k127_2100750_15 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 425.0
TLS2_k127_2100750_16 Conserved hypothetical ATP binding protein K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008298 390.0
TLS2_k127_2100750_17 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008636 391.0
TLS2_k127_2100750_18 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 388.0
TLS2_k127_2100750_19 Belongs to the arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 361.0
TLS2_k127_2100750_2 magnesium chelatase K03405 - 6.6.1.1 6.25e-288 891.0
TLS2_k127_2100750_20 phosphoserine phosphatase K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 334.0
TLS2_k127_2100750_21 Calcineurin-like phosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 332.0
TLS2_k127_2100750_22 conserved protein implicated in secretion - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 328.0
TLS2_k127_2100750_23 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 326.0
TLS2_k127_2100750_24 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 317.0
TLS2_k127_2100750_25 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 298.0
TLS2_k127_2100750_26 acetolactate synthase, small K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008689 280.0
TLS2_k127_2100750_27 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002627 276.0
TLS2_k127_2100750_28 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006797 271.0
TLS2_k127_2100750_29 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004029 271.0
TLS2_k127_2100750_3 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 3.518e-286 888.0
TLS2_k127_2100750_30 UPF0056 membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001377 255.0
TLS2_k127_2100750_31 Transcriptional regulator K07108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001389 245.0
TLS2_k127_2100750_32 Cytidylyltransferase-like K00952 - 2.7.7.1 0.000000000000000000000000000000000000000000000000000000000000000000004748 238.0
TLS2_k127_2100750_33 - - - - 0.0000000000000000000000000000000000000000000000000000003397 196.0
TLS2_k127_2100750_35 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000007862 181.0
TLS2_k127_2100750_36 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000002853 172.0
TLS2_k127_2100750_37 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03014 - - 0.00000000000000000000000000000000000000000003476 166.0
TLS2_k127_2100750_38 - - - - 0.0000000000000000000000000000000000000000285 160.0
TLS2_k127_2100750_39 snRNP Sm proteins K04796 - - 0.0000000000000000000000000000000000000001897 149.0
TLS2_k127_2100750_4 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.989e-272 845.0
TLS2_k127_2100750_40 Cyclophilin-like K09143 - - 0.000000000000000000000000000000000001572 141.0
TLS2_k127_2100750_41 redox protein, regulator of disulfide bond formation - - - 0.00000000000000000000000000000000001939 137.0
TLS2_k127_2100750_42 - - - - 0.000000000000000000000000000000001255 132.0
TLS2_k127_2100750_43 - - - - 0.00000000000000000000000000002512 125.0
TLS2_k127_2100750_44 S25 ribosomal protein K02975 - - 0.0000000000000000000000000001148 119.0
TLS2_k127_2100750_45 restriction endonuclease K07448 - - 0.0000000000000000000000000001668 119.0
TLS2_k127_2100750_46 Binds to the 23S rRNA K02922 - - 0.00000000000000000000000001916 108.0
TLS2_k127_2100750_47 General stress protein K06884 - - 0.0000000000000001958 87.0
TLS2_k127_2100750_49 Domain of unknown function (DUF892) - - - 0.000000009939 64.0
TLS2_k127_2100750_5 von Willebrand factor, type A K07114 - - 2.805e-233 729.0
TLS2_k127_2100750_51 Cysteine synthase K12339 - 2.5.1.47 0.0003245 43.0
TLS2_k127_2100750_6 carbamoyl-phosphate synthase, small subunit K01956 - 6.3.5.5 1.898e-210 660.0
TLS2_k127_2100750_7 Belongs to the GARS family K01945 - 6.3.4.13 1.582e-198 627.0
TLS2_k127_2100750_8 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005377 557.0
TLS2_k127_2100750_9 Isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 548.0
TLS2_k127_2137341_0 TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009898 458.0
TLS2_k127_2137341_1 TatD related DNase K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006038 334.0
TLS2_k127_2137341_2 Kinase binding protein CGI-121 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003081 245.0
TLS2_k127_2137341_3 Sua5 YciO YrdC YwlC family K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000001797 238.0
TLS2_k127_2137341_4 THUMP domain K06963 - - 0.00000000000000000000000000000000000449 143.0
TLS2_k127_2137341_5 ribosomal protein K02962 - - 0.00000000000000000000000001655 111.0
TLS2_k127_2137341_6 - - - - 0.000002986 50.0
TLS2_k127_2169949_0 Domain of unknown function (DUF1297) K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 597.0
TLS2_k127_2169949_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 311.0
TLS2_k127_2169949_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006887 269.0
TLS2_k127_2169949_3 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000000000000000000000000000006356 230.0
TLS2_k127_2169949_4 - - - - 0.0000000000000000000000000000000000000001413 154.0
TLS2_k127_2169949_5 mttA/Hcf106 family K03116 - - 0.000000000000000000000000000000000000001804 149.0
TLS2_k127_218221_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0 1022.0
TLS2_k127_218221_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 2.389e-300 927.0
TLS2_k127_218221_10 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 507.0
TLS2_k127_218221_11 8-amino-7-oxononanoate synthase K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004605 503.0
TLS2_k127_218221_12 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 458.0
TLS2_k127_218221_13 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 456.0
TLS2_k127_218221_14 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000055 370.0
TLS2_k127_218221_15 conserved protein implicated in secretion - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 344.0
TLS2_k127_218221_16 resolvase K14060 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000824 316.0
TLS2_k127_218221_17 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 315.0
TLS2_k127_218221_18 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000278 245.0
TLS2_k127_218221_19 Lysine exporter protein LysE YggA - - - 0.000000000000000000000000000000000000000000000000000000000000001686 224.0
TLS2_k127_218221_2 HELICc2 - - - 2.484e-269 838.0
TLS2_k127_218221_20 HIT domain K02503 - - 0.000000000000000000000000000000000000000000000000000000000001335 212.0
TLS2_k127_218221_21 Transcription elongation factor - - - 0.00000000000000000000000000000000000000000000000000000000043 206.0
TLS2_k127_218221_22 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000009144 173.0
TLS2_k127_218221_23 - - - - 0.00000000000000000000000000000000000000000000001173 174.0
TLS2_k127_218221_24 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000004367 169.0
TLS2_k127_218221_25 - - - - 0.00000000000000000000000000000000000000002046 154.0
TLS2_k127_218221_26 - - - - 0.00000000000000000000000000000000000000003749 152.0
TLS2_k127_218221_28 metal-dependent protease of the PAD1 JAB1 superfamily K21140 - 3.13.1.6 0.000000000000000000000000000009784 122.0
TLS2_k127_218221_29 - - - - 0.00000000000000000000000002736 109.0
TLS2_k127_218221_3 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 6.641e-265 818.0
TLS2_k127_218221_31 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000003051 103.0
TLS2_k127_218221_32 PFAM blue (type 1) copper domain protein - - - 0.000000000000004083 76.0
TLS2_k127_218221_33 Functions by promoting the formation of the first peptide bond K03263 - - 0.000004807 51.0
TLS2_k127_218221_34 Luciferase-like monooxygenase - - - 0.0003341 44.0
TLS2_k127_218221_4 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) - - - 3.441e-226 706.0
TLS2_k127_218221_5 inner membrane component K02034 - - 3.866e-211 664.0
TLS2_k127_218221_6 component I K01657 - 4.1.3.27 3.518e-206 649.0
TLS2_k127_218221_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 2.554e-196 620.0
TLS2_k127_218221_8 PFAM Radical SAM domain protein - - - 1.383e-195 615.0
TLS2_k127_218221_9 inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006094 553.0
TLS2_k127_2323398_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1405.0
TLS2_k127_2323398_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1375.0
TLS2_k127_2323398_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000007087 237.0
TLS2_k127_2323398_11 Thioredoxin K03671 - - 0.000000000000000000000000000000000000000000000000000001091 194.0
TLS2_k127_2323398_13 endonuclease K00986 - 2.7.7.49 0.0000000000000000000001398 100.0
TLS2_k127_2323398_16 ChaB K06197 - - 0.00000000000001465 78.0
TLS2_k127_2323398_17 SMART nuclease (SNase domain protein) K01174 - 3.1.31.1 0.00000000006286 75.0
TLS2_k127_2323398_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.149e-245 761.0
TLS2_k127_2323398_3 F420-0:Gamma-glutamyl ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005368 361.0
TLS2_k127_2323398_4 3-isopropylmalate dehydratase, small subunit K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 291.0
TLS2_k127_2323398_5 helix_turn_helix ASNC type K03718 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009653 268.0
TLS2_k127_2323398_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005893 258.0
TLS2_k127_2323398_7 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002084 257.0
TLS2_k127_2323398_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001018 241.0
TLS2_k127_2323398_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000004539 238.0
TLS2_k127_2344573_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1304.0
TLS2_k127_2344573_1 UbiD family decarboxylase K03182 - 4.1.1.98 1.8e-268 835.0
TLS2_k127_2344573_10 Diphthamide synthase K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003943 290.0
TLS2_k127_2344573_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003773 250.0
TLS2_k127_2344573_12 COG0433 Predicted ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000488 259.0
TLS2_k127_2344573_13 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001656 228.0
TLS2_k127_2344573_14 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000000000000000000000000056 224.0
TLS2_k127_2344573_15 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00000000000000000000000000000000000000008299 155.0
TLS2_k127_2344573_17 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000000000000002658 109.0
TLS2_k127_2344573_18 glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000002658 62.0
TLS2_k127_2344573_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 1.322e-234 731.0
TLS2_k127_2344573_3 Radical SAM K18285 - 2.5.1.120 5.78e-200 627.0
TLS2_k127_2344573_4 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) - - - 7.28e-200 627.0
TLS2_k127_2344573_5 Nucleotidyltransferase domain K07076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 592.0
TLS2_k127_2344573_6 Mg2 transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007837 486.0
TLS2_k127_2344573_7 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 393.0
TLS2_k127_2344573_8 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 336.0
TLS2_k127_2344573_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 292.0
TLS2_k127_2403802_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 1.76e-200 633.0
TLS2_k127_2403802_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000053 567.0
TLS2_k127_2403802_10 - - - - 0.0000000000000000000000000000000000000000009977 158.0
TLS2_k127_2403802_11 CBS domain K03498 - - 0.00000000000000000000000000000000008439 138.0
TLS2_k127_2403802_13 - - - - 0.0000000000000000000001261 97.0
TLS2_k127_2403802_14 synthetase (class II) K01880 - 6.1.1.14 0.0000000000005498 69.0
TLS2_k127_2403802_2 Archaeal ammonia monooxygenase subunit A (AmoA) K10944 - 1.14.18.3,1.14.99.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008681 435.0
TLS2_k127_2403802_3 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 350.0
TLS2_k127_2403802_4 Belongs to the peptidase M50B family - GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 362.0
TLS2_k127_2403802_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007745 343.0
TLS2_k127_2403802_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001245 263.0
TLS2_k127_2403802_7 PFAM Methyltransferase type K15256 - - 0.000000000000000000000000000000000000000000000000000000000000000001439 231.0
TLS2_k127_2403802_9 - - - - 0.00000000000000000000000000000000000000000000007921 169.0
TLS2_k127_2414571_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 387.0
TLS2_k127_2414571_1 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 325.0
TLS2_k127_2414571_2 Class II aldolase adducin family protein K01628,K03077 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008270,GO:0008738,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019321,GO:0019323,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046872,GO:0046914,GO:0071704,GO:1901575 4.1.2.17,5.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000002655 225.0
TLS2_k127_2414571_3 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000000000000000006714 170.0
TLS2_k127_2424600_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K11131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 589.0
TLS2_k127_2424600_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 354.0
TLS2_k127_2424600_2 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004322 273.0
TLS2_k127_2424600_3 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002555 269.0
TLS2_k127_2424600_4 Belongs to the archaeal adenylate kinase family K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000469 256.0
TLS2_k127_2424600_6 Universal stress protein family - - - 0.0000000001332 66.0
TLS2_k127_246453_0 Winged helix-turn-helix DNA-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000002306 226.0
TLS2_k127_246453_1 - - - - 0.0000000000000000000000000003426 118.0
TLS2_k127_246453_2 - - - - 0.000000000004048 67.0
TLS2_k127_2469289_0 Protein of unknown function, DUF255 K06888 - - 0.0 1065.0
TLS2_k127_2469289_1 - - - - 0.0000000000000000000000000000000000000000009854 158.0
TLS2_k127_2469289_3 - - - - 0.00000000000000005637 81.0
TLS2_k127_251098_0 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 479.0
TLS2_k127_251098_1 COG0668 Small-conductance mechanosensitive channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001413 243.0
TLS2_k127_251098_2 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000002345 179.0
TLS2_k127_251098_3 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000005476 106.0
TLS2_k127_251098_4 Short-chain dehydrogenase reductase sdr - - - 0.000003911 50.0
TLS2_k127_251098_5 PFAM Aldehyde dehydrogenase K00135,K18601 - 1.2.1.16,1.2.1.20,1.2.1.79 0.000009263 48.0
TLS2_k127_259394_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1637.0
TLS2_k127_259394_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1075.0
TLS2_k127_259394_10 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.00000000002909 76.0
TLS2_k127_259394_11 MiaB-like tRNA modifying enzyme K15865 - 2.8.4.5 0.00000001187 57.0
TLS2_k127_259394_2 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K00313 - - 1.196e-321 992.0
TLS2_k127_259394_3 TIGRFAM excinuclease ABC, C subunit K03703 - - 7.898e-234 734.0
TLS2_k127_259394_4 Electron transfer flavoprotein domain K03522 - - 1.446e-195 615.0
TLS2_k127_259394_5 Electron transfer flavoprotein domain K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 467.0
TLS2_k127_259394_6 HD domain K00951,K01139 - 2.7.6.5,3.1.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 314.0
TLS2_k127_259394_7 Redoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003086 305.0
TLS2_k127_2598074_0 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002161 256.0
TLS2_k127_2598074_1 CBS domain - - - 0.0000000000000000000000000000000000000000004675 161.0
TLS2_k127_2598074_2 Major Facilitator Superfamily - - - 0.0000000000000000000000004438 119.0
TLS2_k127_2598074_3 alpha beta - - - 0.000000000000001066 78.0
TLS2_k127_2598074_4 Transcriptional regulator - - - 0.000000000002678 70.0
TLS2_k127_2634331_0 PFAM MazG nucleotide pyrophosphohydrolase - - - 0.0000000000000000000000000001088 117.0
TLS2_k127_2650196_0 Isocitrate isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 571.0
TLS2_k127_2650196_1 Tetrapyrrole (Corrin/Porphyrin) Methylases K05934 - 2.1.1.131 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 474.0
TLS2_k127_2650196_2 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006106 391.0
TLS2_k127_2650196_3 Protein of unknown function (DUF655) K07572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 319.0
TLS2_k127_2650196_4 Monooxygenase subunit B protein K10945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007447 305.0
TLS2_k127_2650196_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000001232 261.0
TLS2_k127_2650196_6 Methyltransferase small domain K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000009624 181.0
TLS2_k127_2650196_7 RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000000000000000000000000000000000000003746 164.0
TLS2_k127_2650196_8 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.000000000000000000000000000000000000000001485 158.0
TLS2_k127_2650196_9 - - - - 0.000000002666 59.0
TLS2_k127_2661792_0 Major royal jelly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008106 575.0
TLS2_k127_2661792_1 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 331.0
TLS2_k127_2661792_2 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 285.0
TLS2_k127_2661792_3 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000005916 184.0
TLS2_k127_2661792_4 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000001297 110.0
TLS2_k127_2661792_5 AsnC-type helix-turn-helix domain - - - 0.0000000004905 70.0
TLS2_k127_2680988_0 Glycosyl transferase family group 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 556.0
TLS2_k127_2680988_1 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases K01090,K06269 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 336.0
TLS2_k127_2680988_2 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000005575 227.0
TLS2_k127_270300_0 SMC proteins Flexible Hinge Domain K03529 - - 0.0 1425.0
TLS2_k127_270300_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0 1082.0
TLS2_k127_270300_10 Domain of unknown function DUF120 K07732 - 2.7.1.161 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 383.0
TLS2_k127_270300_11 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 370.0
TLS2_k127_270300_12 Cytidylyltransferase-like K00980,K14656 - 2.7.7.2,2.7.7.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 334.0
TLS2_k127_270300_13 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 312.0
TLS2_k127_270300_14 CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 297.0
TLS2_k127_270300_15 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 286.0
TLS2_k127_270300_16 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000000000000000000000000000000000000000000000001242 232.0
TLS2_k127_270300_17 Cation efflux family K16264 - - 0.00000000000000000000000000000000000000000000000000000000000003777 225.0
TLS2_k127_270300_18 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000000000000002786 174.0
TLS2_k127_270300_19 - - - - 0.00000000000000000000000000000000000002299 145.0
TLS2_k127_270300_2 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 4.949e-318 987.0
TLS2_k127_270300_20 ATP synthase subunit C K02124 - - 0.0000000000000000000000000000000000002136 145.0
TLS2_k127_270300_21 - - - - 0.000000000000000000000000000000000006963 139.0
TLS2_k127_270300_22 - - - - 0.00000000000000000002421 93.0
TLS2_k127_270300_23 - - - - 0.000000000000002508 77.0
TLS2_k127_270300_24 Glycosyl transferase family group 2 - - - 0.0000000000001686 83.0
TLS2_k127_270300_3 Fibronectin-binding protein A N-terminus (FbpA) - - - 2.373e-286 896.0
TLS2_k127_270300_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 1.078e-267 827.0
TLS2_k127_270300_5 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 5.685e-248 775.0
TLS2_k127_270300_6 DNA primase K02316 - - 1.646e-200 631.0
TLS2_k127_270300_7 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 589.0
TLS2_k127_270300_8 Archaeal Nre, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004252 536.0
TLS2_k127_270300_9 ATP synthase (C/AC39) subunit K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 529.0
TLS2_k127_2716772_0 Winged helix-turn-helix - - - 0.000000000000000000000000000000000000000000000001524 176.0
TLS2_k127_2716772_1 Cupredoxin-like domain - - - 0.000000000000000000000000000000000000000000000003774 179.0
TLS2_k127_2716772_2 - - - - 0.00000000000000000000000000000000000000000000009751 171.0
TLS2_k127_2716772_3 - - - - 0.0000000000004556 71.0
TLS2_k127_273624_0 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006395 444.0
TLS2_k127_273624_1 Ribose-phosphate pyrophosphokinase K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007111 339.0
TLS2_k127_273624_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001762 282.0
TLS2_k127_273624_3 Domain of unknown function (DUF309) K09763 - - 0.00000000000000000000000000000000000000000000000000000000000000225 223.0
TLS2_k127_273624_5 - - - - 0.000000000000000000000000000003395 121.0
TLS2_k127_273624_7 - - - - 0.00000000003605 67.0
TLS2_k127_2768241_1 PFAM Mechanosensitive ion channel - - - 0.000000000000002984 83.0
TLS2_k127_278776_0 NAD-dependent epimerase dehydratase K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 423.0
TLS2_k127_278776_1 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006857 282.0
TLS2_k127_278776_2 PFAM TatD-related deoxyribonuclease K07051 - - 0.0000000000000000000000000000000000000000000000000000000000000000002522 237.0
TLS2_k127_278776_3 PFAM UbiA prenyltransferase K03179 - 2.5.1.39 0.00000000000000000000000000000008724 136.0
TLS2_k127_2813300_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 5.331e-299 932.0
TLS2_k127_2813300_1 methylase K00590 - 2.1.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 515.0
TLS2_k127_2850802_0 CBS domain K03498 - - 5.036e-257 808.0
TLS2_k127_2850802_1 - - - - 0.000001407 53.0
TLS2_k127_2851725_0 Radical SAM K11781 - 2.5.1.77 8.212e-228 710.0
TLS2_k127_2851725_1 Radical SAM K11780 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006994 573.0
TLS2_k127_2851725_2 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 454.0
TLS2_k127_2851725_3 Membrane - - - 0.000000000000000000000000000000000000000002949 167.0
TLS2_k127_2851725_5 Transcriptional regulator - - - 0.00000000000000000000000004137 109.0
TLS2_k127_2851725_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0001504 52.0
TLS2_k127_2896817_0 Belongs to the TPP enzyme family - - - 2.198e-201 642.0
TLS2_k127_2896817_1 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004679 462.0
TLS2_k127_2896817_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 354.0
TLS2_k127_2896817_3 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000007618 242.0
TLS2_k127_2896817_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 GO:0003674,GO:0003824,GO:0003861,GO:0016829,GO:0016835,GO:0016836 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000258 183.0
TLS2_k127_2896817_5 PPIC-type PPIASE domain K07533 - 5.2.1.8 0.00000000000000000000000000000000000000007966 152.0
TLS2_k127_2896817_6 - - - - 0.0000000000000000000000000000387 119.0
TLS2_k127_2896817_7 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000002623 121.0
TLS2_k127_2896817_8 Cupin domain K01607 - 4.1.1.44 0.0000268 53.0
TLS2_k127_2932584_0 AAA family ATPase, CDC48 subfamily K13525 - - 9.278e-265 835.0
TLS2_k127_2932584_1 S-adenosylmethionine synthetase K00789 - 2.5.1.6 2.549e-210 657.0
TLS2_k127_2932584_2 glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 502.0
TLS2_k127_2932584_3 RecA RadA K04482,K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000001696 231.0
TLS2_k127_2932584_4 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000000000000000000000000000000006077 201.0
TLS2_k127_2932584_5 dUTPase - - - 0.0000000000000000000000000000000000000000000000000008277 187.0
TLS2_k127_2932584_6 Tetrahydromethanopterin S-methyltransferase, subunit A K00577 - 2.1.1.86 0.00000000000000000000000000000000000000000000000006524 182.0
TLS2_k127_2932584_7 snRNP Sm proteins K04796 - - 0.0000000000000000000000000000000000009384 139.0
TLS2_k127_296488_0 GTPase of unknown function C-terminal K06942 - - 3.397e-210 660.0
TLS2_k127_296488_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008438 541.0
TLS2_k127_296488_2 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 366.0
TLS2_k127_296488_3 protein with SCP PR1 domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 360.0
TLS2_k127_296488_4 Queuosine biosynthesis protein QueC K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 324.0
TLS2_k127_296488_5 GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005137 305.0
TLS2_k127_296488_6 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000000000000000000004187 177.0
TLS2_k127_296488_7 - - - - 0.00000000000000000000000000000000003383 137.0
TLS2_k127_296488_8 Mn2 -dependent serine threonine protein kinase K08851 - 2.7.11.1 0.0003683 45.0
TLS2_k127_3005047_0 Glycosyl transferase family group 2 - - - 7.113e-284 888.0
TLS2_k127_3005047_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009137 268.0
TLS2_k127_3005047_2 PFAM regulatory protein, ArsR - - - 0.0000000000000000000000000000000000000000000000000000000000000003669 222.0
TLS2_k127_3005047_3 ferredoxin - - - 0.0000000000000000000001936 96.0
TLS2_k127_3039074_0 Enoyl-(Acyl carrier protein) reductase - - - 6.34e-279 868.0
TLS2_k127_3039074_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex - - - 1.798e-238 747.0
TLS2_k127_3039074_10 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 332.0
TLS2_k127_3039074_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000408 318.0
TLS2_k127_3039074_12 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001181 278.0
TLS2_k127_3039074_13 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003541 285.0
TLS2_k127_3039074_14 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006503 263.0
TLS2_k127_3039074_15 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004702 241.0
TLS2_k127_3039074_16 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000005971 240.0
TLS2_k127_3039074_17 Domain of unknown function (DUF371) K09738 - - 0.000000000000000000000000000000000000000000000000001144 188.0
TLS2_k127_3039074_18 PUA domain K07575 - - 0.000000000000000000000000000000000000000000000000009342 184.0
TLS2_k127_3039074_19 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000006015 163.0
TLS2_k127_3039074_2 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009692 549.0
TLS2_k127_3039074_20 - - - - 0.00000000000000000000000000000000000001807 147.0
TLS2_k127_3039074_21 Located at the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000000003327 142.0
TLS2_k127_3039074_22 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.000000000000000000000000000000007588 131.0
TLS2_k127_3039074_23 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000000001438 123.0
TLS2_k127_3039074_24 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.00000000000000000000001665 102.0
TLS2_k127_3039074_25 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000000000000005606 88.0
TLS2_k127_3039074_26 - - - - 0.0000000000000001785 82.0
TLS2_k127_3039074_3 ribosomal protein L3 K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006205 544.0
TLS2_k127_3039074_4 homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 536.0
TLS2_k127_3039074_5 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 424.0
TLS2_k127_3039074_6 Proteasome endopeptidase complex K03432 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 418.0
TLS2_k127_3039074_7 Ribosomal protein L4 K02930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005822 407.0
TLS2_k127_3039074_8 Putative RNA methyltransferase K09142 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 404.0
TLS2_k127_3039074_9 Binds the lower part of the 30S subunit head K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008357 336.0
TLS2_k127_3046319_0 PFAM Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005346 340.0
TLS2_k127_3046319_1 - - - - 0.00000000000000000000000000000000000001168 155.0
TLS2_k127_3070961_0 Ammonium Transporter K03320 - - 9.771e-234 726.0
TLS2_k127_3070961_1 Amino acid kinase family K00928 - 2.7.2.4 1.607e-231 723.0
TLS2_k127_3070961_10 Translation initiation factor K03238 - - 0.00000000000000000000000000000000000000000000000000000000000000001781 226.0
TLS2_k127_3070961_11 PFAM DNA methylase N-4 N-6 K07316 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000001887 216.0
TLS2_k127_3070961_13 PFAM 4Fe-4S dicluster domain - - - 0.000000000000000002655 84.0
TLS2_k127_3070961_2 Arsenite-activated ATPase ArsA K01551,K13993 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 599.0
TLS2_k127_3070961_3 methylase K00590 - 2.1.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004638 570.0
TLS2_k127_3070961_4 aspartate carbamoyltransferase K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 512.0
TLS2_k127_3070961_5 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009713 495.0
TLS2_k127_3070961_6 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 394.0
TLS2_k127_3070961_7 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007552 352.0
TLS2_k127_3070961_8 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 344.0
TLS2_k127_3070961_9 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 321.0
TLS2_k127_3081174_0 PFAM aminotransferase class-III K01845 - 5.4.3.8 4.033e-204 641.0
TLS2_k127_3081174_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 475.0
TLS2_k127_3081174_10 Putative TM nitroreductase - - - 0.0002405 44.0
TLS2_k127_3081174_2 Belongs to the precorrin methyltransferase family K02303 - 2.1.1.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 304.0
TLS2_k127_3081174_3 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000001624 247.0
TLS2_k127_3081174_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000003923 228.0
TLS2_k127_3081174_5 - - - - 0.000000000000000000000000000000000000000000000000000000000287 206.0
TLS2_k127_3081174_6 PAC2 family K06869 - - 0.000000000000000000000000000000000000000000000000005238 192.0
TLS2_k127_3081174_7 Nitroreductase - - - 0.00000000000000000000000000000000000003245 146.0
TLS2_k127_3081174_8 Thiamine-binding protein - - - 0.000000000000000000003019 96.0
TLS2_k127_3081174_9 Transcriptional regulator - - - 0.000003837 53.0
TLS2_k127_3095289_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 560.0
TLS2_k127_3095289_1 PFAM regulatory protein, ArsR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 533.0
TLS2_k127_3095289_10 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.000000000000000000000000000000002255 132.0
TLS2_k127_3095289_11 IMP dehydrogenase activity - - - 0.0000000000000001911 79.0
TLS2_k127_3095289_12 PFAM GvpD gas vesicle - - - 0.00000000000001162 87.0
TLS2_k127_3095289_13 Transcriptional regulator - - - 0.0000000002149 65.0
TLS2_k127_3095289_15 Transcriptional regulator - - - 0.00000006098 57.0
TLS2_k127_3095289_2 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006051 382.0
TLS2_k127_3095289_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004442 317.0
TLS2_k127_3095289_4 Siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006651 315.0
TLS2_k127_3095289_5 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004395 316.0
TLS2_k127_3095289_6 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005466 256.0
TLS2_k127_3095289_7 Binds to the 23S rRNA K02885 - - 0.000000000000000000000000000000000000000000000000000000000000000000002087 238.0
TLS2_k127_3095289_8 - - - - 0.000000000000000000000000000000000000000000000000000000004285 202.0
TLS2_k127_3095289_9 ribosomal protein K02912 - - 0.0000000000000000000000000000000000000000000000000000007297 195.0
TLS2_k127_3113367_0 DEAD/H associated K03724 - - 0.0 1500.0
TLS2_k127_3113367_1 Succinyl-CoA ligase like flavodoxin domain K18593 - - 0.0 1222.0
TLS2_k127_3113367_10 tRNA pseudouridine synthase K06176 - 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007901 574.0
TLS2_k127_3113367_11 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 494.0
TLS2_k127_3113367_12 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 414.0
TLS2_k127_3113367_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006853 348.0
TLS2_k127_3113367_15 thymidylate kinase K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 325.0
TLS2_k127_3113367_16 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 310.0
TLS2_k127_3113367_17 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 306.0
TLS2_k127_3113367_18 Zinc finger domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 301.0
TLS2_k127_3113367_19 Protein of unknown function DUF45 K07043 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004515 273.0
TLS2_k127_3113367_2 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 3.205e-292 910.0
TLS2_k127_3113367_20 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000007944 223.0
TLS2_k127_3113367_21 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000000000000000000000005402 169.0
TLS2_k127_3113367_22 - - - - 0.000000000000000000000000000000000000000000009443 164.0
TLS2_k127_3113367_23 - - - - 0.0000000000000000000000000000000000000000002835 164.0
TLS2_k127_3113367_24 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000002175 156.0
TLS2_k127_3113367_25 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000000000000004446 143.0
TLS2_k127_3113367_27 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000004612 124.0
TLS2_k127_3113367_28 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.0000000000000000000000000002464 114.0
TLS2_k127_3113367_3 ABC1 family - - - 1.656e-250 782.0
TLS2_k127_3113367_30 - - - - 0.000000000000000000000003577 117.0
TLS2_k127_3113367_31 Transcriptional regulator - - - 0.0000000000000000000008904 97.0
TLS2_k127_3113367_34 Transcriptional regulator - - - 0.000000000000002064 80.0
TLS2_k127_3113367_38 - - - - 0.0000004287 53.0
TLS2_k127_3113367_4 Peptidase dimerisation domain - - - 1.185e-232 726.0
TLS2_k127_3113367_5 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 3.8e-224 703.0
TLS2_k127_3113367_6 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 7.964e-213 663.0
TLS2_k127_3113367_7 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 6.49e-207 650.0
TLS2_k127_3113367_8 - - - - 2.596e-196 619.0
TLS2_k127_3113367_9 Tyrosine--tRNA ligase K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 588.0
TLS2_k127_3159112_0 zinc finger - - - 0.0000000000000000000000000000000000000000000000000002787 189.0
TLS2_k127_3159112_1 Sodium:sulfate symporter transmembrane region K14445 - - 0.000000000000000000000000000006214 120.0
TLS2_k127_3159112_2 DNA polymerase K02319 - 2.7.7.7 0.000000006054 61.0
TLS2_k127_3159112_3 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000006263 54.0
TLS2_k127_3172609_0 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 327.0
TLS2_k127_3172609_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000001965 203.0
TLS2_k127_3183941_0 FAD linked - - - 8.19e-199 631.0
TLS2_k127_3183941_1 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004252 327.0
TLS2_k127_3183941_2 Glyoxalase-like domain K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000001192 189.0
TLS2_k127_3183941_3 - - - - 0.000000000002791 74.0
TLS2_k127_3202764_0 PFAM GCN5-related N-acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000000000000000007116 240.0
TLS2_k127_3202764_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004776 235.0
TLS2_k127_3267708_0 DNA polymerase K02319 - 2.7.7.7 0.0 1404.0
TLS2_k127_3267708_1 Belongs to the class-II aminoacyl-tRNA synthetase family K01868 - 6.1.1.3 1.5e-323 998.0
TLS2_k127_3267708_10 Belongs to the UPF0284 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 309.0
TLS2_k127_3267708_11 - - - - 0.00000000000000000000000000000000000000000003933 164.0
TLS2_k127_3267708_12 - - - - 0.00000000000000000000000001032 110.0
TLS2_k127_3267708_14 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000002228 98.0
TLS2_k127_3267708_15 Transcriptional regulator - - - 0.000002709 52.0
TLS2_k127_3267708_2 AAA domain K03546 - - 1.621e-248 784.0
TLS2_k127_3267708_3 Domain of unknown function DUF87 K06915 - - 4.381e-247 770.0
TLS2_k127_3267708_4 FAD dependent oxidoreductase K15736 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 606.0
TLS2_k127_3267708_5 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 502.0
TLS2_k127_3267708_6 Belongs to the arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 482.0
TLS2_k127_3267708_7 NurA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 325.0
TLS2_k127_3267708_8 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX K17759 - 5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 321.0
TLS2_k127_3267708_9 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 312.0
TLS2_k127_3306988_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007333 491.0
TLS2_k127_3306988_1 COG0733 Na -dependent transporters of the SNF family K03308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009404 327.0
TLS2_k127_3306988_2 Universal stress protein - - - 0.000000000000000000000000001031 118.0
TLS2_k127_3306988_3 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0001725 52.0
TLS2_k127_3357177_0 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.681e-201 636.0
TLS2_k127_3357177_1 Sodium:sulfate symporter transmembrane region K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009233 580.0
TLS2_k127_3357177_2 PFAM Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000056 476.0
TLS2_k127_3357177_3 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 330.0
TLS2_k127_3357177_4 PFAM 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000003143 203.0
TLS2_k127_3357177_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.000000000000000000000007798 107.0
TLS2_k127_3357177_7 Protein of unknown function (DUF1622) - - - 0.000006772 52.0
TLS2_k127_3386659_0 DNA polymerase IV (family X) K02347 - - 3.213e-256 800.0
TLS2_k127_3386659_1 Peptidase family M1 domain K01256,K13722 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 386.0
TLS2_k127_3386659_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 374.0
TLS2_k127_3386659_3 MafB19-like deaminase K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009892 332.0
TLS2_k127_3386659_4 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005184 323.0
TLS2_k127_3386659_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000348 265.0
TLS2_k127_3386659_6 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000001863 233.0
TLS2_k127_3386659_7 protein conserved in archaea K09723 - - 0.000000000000000000000000000000000000000000000000000000000000005618 222.0
TLS2_k127_3386659_8 - - - - 0.0000000000000000000000003394 107.0
TLS2_k127_3386659_9 - - - - 0.00000000000000000000001465 104.0
TLS2_k127_3410846_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 3.327e-246 766.0
TLS2_k127_3410846_1 Radical SAM K04069 - 1.97.1.4 1.114e-203 637.0
TLS2_k127_3410846_2 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007111 420.0
TLS2_k127_3410846_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003708 252.0
TLS2_k127_3410846_4 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.0000000000000000000000000000000000003033 145.0
TLS2_k127_3410846_5 RNA polymerase Rpb3/Rpb11 dimerisation domain K03056 - 2.7.7.6 0.000000000000000000000000000000002537 130.0
TLS2_k127_3410846_6 Poly(Beta-D-mannuronate) C5 epimerase K01795 - 5.1.3.37 0.00001158 55.0
TLS2_k127_3438576_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.0 1058.0
TLS2_k127_3438576_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 4.666e-235 735.0
TLS2_k127_3438576_10 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 317.0
TLS2_k127_3438576_11 PFAM TfuA domain protein, core - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005316 281.0
TLS2_k127_3438576_12 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001034 269.0
TLS2_k127_3438576_13 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001438 251.0
TLS2_k127_3438576_14 HD domain K07023 - - 0.0000000000000000000000000000000000000000000000000000000000003759 216.0
TLS2_k127_3438576_15 Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000000000000000000000000000153 209.0
TLS2_k127_3438576_16 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000001496 197.0
TLS2_k127_3438576_17 - - - - 0.00000000000000000000000000000000000000000000000002442 180.0
TLS2_k127_3438576_18 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.0000000000000000000000000000000000000000005236 159.0
TLS2_k127_3438576_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 2.884e-231 721.0
TLS2_k127_3438576_20 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000003483 124.0
TLS2_k127_3438576_22 Transcriptional regulator - - - 0.000000000000000008223 86.0
TLS2_k127_3438576_24 response regulator, receiver - - - 0.00000000000005977 74.0
TLS2_k127_3438576_25 zinc finger K03498 - - 0.0000000002233 61.0
TLS2_k127_3438576_26 alginic acid biosynthetic process K09483 - 4.2.1.118 0.00000001509 66.0
TLS2_k127_3438576_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 4.871e-230 720.0
TLS2_k127_3438576_4 methanogenesis marker protein 1 K09136 - - 7.691e-230 717.0
TLS2_k127_3438576_5 LOR SDH bifunctional - - - 4.307e-216 677.0
TLS2_k127_3438576_6 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 570.0
TLS2_k127_3438576_7 protein (ATP-grasp superfamily) K07159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 387.0
TLS2_k127_3438576_8 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006072 338.0
TLS2_k127_3438576_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 314.0
TLS2_k127_3463109_0 Asp/Glu/Hydantoin racemase K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006895 437.0
TLS2_k127_3463109_1 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 305.0
TLS2_k127_3463109_2 - - - - 0.000000000000000000000000000000007199 129.0
TLS2_k127_3534341_0 ester cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005194 272.0
TLS2_k127_3534341_1 - - - - 0.000000000000000000000000000000000000000000000000004234 189.0
TLS2_k127_3534341_2 membrane protein domain - - - 0.0000000000000000000000000000000000000000000000003564 180.0
TLS2_k127_3534341_3 Protein of unknown function (DUF4242) - - - 0.0000000000000000000123 94.0
TLS2_k127_3538665_0 RNA-metabolising metallo-beta-lactamase K07041 - - 0.0 1146.0
TLS2_k127_3538665_1 ATP-grasp domain K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 590.0
TLS2_k127_3538665_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008936 516.0
TLS2_k127_3538665_3 RNA methylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 316.0
TLS2_k127_3538665_4 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 296.0
TLS2_k127_3538665_5 PFAM Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003031 293.0
TLS2_k127_3538665_6 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase K07305,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000009822 218.0
TLS2_k127_3538665_7 Belongs to the UPF0147 family K09721 - - 0.000000000000000000000000000000000000000000287 159.0
TLS2_k127_3538665_8 Peptidase family M50 - - - 0.000000000000000000000000003203 111.0
TLS2_k127_3565398_0 Succinyl-CoA ligase like flavodoxin domain K18594 - - 0.0 1178.0
TLS2_k127_3565398_1 glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 298.0
TLS2_k127_3565398_3 Toprim domain - - - 0.00000000000000000000000000000000000000000000000000000000002098 209.0
TLS2_k127_3679008_0 transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 514.0
TLS2_k127_3679008_1 Mg2 transporter protein K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 414.0
TLS2_k127_3679008_2 aldo-keto reductase (NADP) activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005039 362.0
TLS2_k127_3679008_3 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000000004938 132.0
TLS2_k127_3679008_4 conserved protein implicated in secretion - - - 0.00000000000000000005144 93.0
TLS2_k127_3679008_6 Glyoxalase bleomycin resistance protein dioxygenase K07104 - 1.13.11.2 0.0000171 48.0
TLS2_k127_3682724_0 resistance protein K14166 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008159 551.0
TLS2_k127_3682724_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K15510,K21835 - 1.1.98.2,1.1.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003904 463.0
TLS2_k127_3682724_2 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001545 280.0
TLS2_k127_3682724_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001256 252.0
TLS2_k127_3796725_0 fumarate reductase flavoprotein K00239 - 1.3.5.1,1.3.5.4 0.0 1010.0
TLS2_k127_3796725_1 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009115 580.0
TLS2_k127_3796725_10 - - - - 0.0000000000000000000000000000000000002504 142.0
TLS2_k127_3796725_2 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 502.0
TLS2_k127_3796725_3 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 436.0
TLS2_k127_3796725_4 Belongs to the MCM family K10726 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 381.0
TLS2_k127_3796725_5 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002575 258.0
TLS2_k127_3796725_6 Iron-sulfur cluster assembly protein - - - 0.0000000000000000000000000000000000000000000000000001133 187.0
TLS2_k127_3796725_7 Archease protein family (MTH1598/TM1083) - - - 0.0000000000000000000000000000000000000000000000000003624 190.0
TLS2_k127_3796725_8 - - - - 0.000000000000000000000000000000000000000000001911 166.0
TLS2_k127_3796725_9 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.000000000000000000000000000000000000000003126 158.0
TLS2_k127_3800186_0 UbiD family decarboxylase - - - 4.187e-214 672.0
TLS2_k127_3800186_1 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 445.0
TLS2_k127_3800186_3 Copper resistance protein D - - - 0.000000000000000000000000000000000000000000000000000000000000013 219.0
TLS2_k127_3800186_5 - - - - 0.0000000000000000000000000000000003131 131.0
TLS2_k127_3800186_6 - - - - 0.00000000000000000000000000000008222 130.0
TLS2_k127_3800186_7 - - - - 0.000000000000000000000000001568 115.0
TLS2_k127_3866061_0 hydroxymethylglutaryl-CoA reductase (NADPH) activity K00021 - 1.1.1.34 5.52e-212 672.0
TLS2_k127_3866061_1 COG1335 Amidases related to nicotinamidase K09020 - 3.5.1.110 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 340.0
TLS2_k127_3866061_10 N-methylhydantoinase A acetone carboxylase, beta subunit - - - 0.0006157 42.0
TLS2_k127_3866061_2 PFAM D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009675 278.0
TLS2_k127_3866061_3 PFAM Iron dependent repressor, metal binding and dimerisation domain K03709 - - 0.000000000000000000000000000000000000000000000000000000000000000000001 242.0
TLS2_k127_3866061_4 ABC-type phosphate phosphonate transport system, periplasmic component K02044 - - 0.00000000000000000000000000000000000000000000000000000000629 210.0
TLS2_k127_3866061_5 phosphonate ABC transporter, inner membrane subunit K02042 - - 0.0000000000000000000000000000000000000000000000000008045 192.0
TLS2_k127_3866061_6 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.000000000000000000000000000000000000000009977 163.0
TLS2_k127_3866061_7 - - - - 0.0000000000000000000000000000001092 136.0
TLS2_k127_3866061_8 N-methylhydantoinase A acetone carboxylase, beta subunit - - - 0.000000000000000006096 84.0
TLS2_k127_3866061_9 High-affinity Fe2 Pb2 permease K07243 - - 0.000000006923 60.0
TLS2_k127_3866946_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 550.0
TLS2_k127_3866946_1 Belongs to the peptidase M24B family K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 429.0
TLS2_k127_3866946_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008935 416.0
TLS2_k127_3866946_3 Pfam:DUF137 K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 325.0
TLS2_k127_3866946_4 kinase, sugar kinase superfamily K06982 - 2.7.1.169 0.0000000007944 60.0
TLS2_k127_3907103_0 Belongs to the MCM family K10726 - - 0.0 1193.0
TLS2_k127_3907103_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.0 1021.0
TLS2_k127_3907103_2 Replication factor C K04801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006339 474.0
TLS2_k127_3907103_3 glycosyl transferase family K01001 - 2.7.8.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009556 375.0
TLS2_k127_3907103_4 GINS complex protein K09723 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005215 267.0
TLS2_k127_3907103_5 Belongs to the class-I aminoacyl-tRNA synthetase family - - - 0.0000000000000000000000000000000000000000003276 161.0
TLS2_k127_3914180_0 DEAD DEAH box helicase K06877 - - 0.0 1285.0
TLS2_k127_3914180_1 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 2.734e-277 859.0
TLS2_k127_3914180_10 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007965 461.0
TLS2_k127_3914180_11 major facilitator superfamily K08153,K08221 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 375.0
TLS2_k127_3914180_12 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008996 348.0
TLS2_k127_3914180_13 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004448 336.0
TLS2_k127_3914180_14 zinc finger K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 325.0
TLS2_k127_3914180_15 membrane-associated protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 339.0
TLS2_k127_3914180_16 phosphoribosylglycinamide formyltransferase K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009266 323.0
TLS2_k127_3914180_17 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006308 250.0
TLS2_k127_3914180_18 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000003659 152.0
TLS2_k127_3914180_19 - - - - 0.0000000000000000000000000000000000003546 143.0
TLS2_k127_3914180_2 Belongs to the RtcB family K14415 - 6.5.1.3 1.513e-267 829.0
TLS2_k127_3914180_20 - - - - 0.00000000000000000000000000000000001101 140.0
TLS2_k127_3914180_21 - - - - 0.000000000000000000000007071 104.0
TLS2_k127_3914180_22 phosphohydrolase (DHH superfamily) K07097 - - 0.00000000000000000001407 92.0
TLS2_k127_3914180_23 - - - - 0.00001876 55.0
TLS2_k127_3914180_3 DNA Topoisomerase I (eukaryota) K03163 - 5.99.1.2 7.213e-267 830.0
TLS2_k127_3914180_4 Histone acetyltransferase K07739 - 2.3.1.48 3.64e-261 813.0
TLS2_k127_3914180_5 TIGRFAM 2-methylcitrate synthase citrate synthase II K01647 - 2.3.3.1 2.376e-217 677.0
TLS2_k127_3914180_6 Luciferase-like monooxygenase K14728 - - 7.202e-213 663.0
TLS2_k127_3914180_7 adenylosuccinate lyase K01756 - 4.3.2.2 4.641e-212 667.0
TLS2_k127_3914180_8 phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 591.0
TLS2_k127_3914180_9 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 505.0
TLS2_k127_3936355_0 Ammonium Transporter K03320 - - 3.937e-236 738.0
TLS2_k127_3936355_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 378.0
TLS2_k127_3936355_2 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 377.0
TLS2_k127_3936355_3 COG2002 Regulators of stationary sporulation gene expression - - - 0.0000000000000000000000000000000000000007192 150.0
TLS2_k127_3936355_4 RNA-binding protein contains TRAM domain - - - 0.000000000000000000000000000000002343 132.0
TLS2_k127_3948447_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 5.629e-296 914.0
TLS2_k127_3948447_1 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 601.0
TLS2_k127_3948447_10 Hexapeptide repeat of succinyl-transferase K02536 - 2.3.1.191 0.00000000000000000000000000000000000000135 159.0
TLS2_k127_3948447_11 Glycosyl transferase family 21 K19003 - 2.4.1.336 0.00000000000000000000000000000003939 141.0
TLS2_k127_3948447_12 regulatory protein, arsR - - - 0.0000000000000000000000000000172 120.0
TLS2_k127_3948447_14 PFAM 4Fe-4S dicluster domain - - - 0.000000000000000001932 85.0
TLS2_k127_3948447_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 540.0
TLS2_k127_3948447_3 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 385.0
TLS2_k127_3948447_4 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003457 375.0
TLS2_k127_3948447_5 PFAM UDP-N-acetylglucosamine 2-epimerase K01791 GO:0003674,GO:0003824,GO:0008761,GO:0016853,GO:0016854,GO:0016857 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000002991 259.0
TLS2_k127_3948447_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.000000000000000000000000000000000000000000000000000000000000000004761 232.0
TLS2_k127_3948447_7 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000006445 214.0
TLS2_k127_3948447_8 ribosomal protein K02976 - - 0.000000000000000000000000000000000000000000000007297 172.0
TLS2_k127_3948447_9 LmbE homologs - - - 0.00000000000000000000000000000000000000000003434 169.0
TLS2_k127_3961403_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K01953,K06927 - 6.3.1.14,6.3.5.4 2.658e-235 739.0
TLS2_k127_3961403_1 Mannosyl-3-phosphoglycerate synthase K05947 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.217 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 468.0
TLS2_k127_3961403_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006454 348.0
TLS2_k127_3961403_3 phosphoserine phosphatase K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002222 273.0
TLS2_k127_3961403_4 Bifunctional nuclease K08999 - - 0.0000000000000000000006186 96.0
TLS2_k127_3978392_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1367.0
TLS2_k127_3978392_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01581,K01586,K13747 - 4.1.1.17,4.1.1.20,4.1.1.96 6.908e-243 755.0
TLS2_k127_3978392_10 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000852 370.0
TLS2_k127_3978392_11 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 322.0
TLS2_k127_3978392_12 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 317.0
TLS2_k127_3978392_13 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 312.0
TLS2_k127_3978392_15 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 283.0
TLS2_k127_3978392_16 PFAM 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001766 259.0
TLS2_k127_3978392_18 - - - - 0.00000000000000000000000000000000000000000002803 166.0
TLS2_k127_3978392_2 Glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 565.0
TLS2_k127_3978392_20 - - - - 0.00000000000000000000000008732 110.0
TLS2_k127_3978392_21 Acylphosphatase K01512 - 3.6.1.7 0.0000000000000000000000005607 106.0
TLS2_k127_3978392_22 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.000000000000002002 76.0
TLS2_k127_3978392_3 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005869 541.0
TLS2_k127_3978392_4 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005886 520.0
TLS2_k127_3978392_5 CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 500.0
TLS2_k127_3978392_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 458.0
TLS2_k127_3978392_7 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 425.0
TLS2_k127_3978392_8 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 428.0
TLS2_k127_3978392_9 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 394.0
TLS2_k127_4002305_1 ParB-like nuclease domain K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003973 417.0
TLS2_k127_4002305_2 COG1522 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001248 280.0
TLS2_k127_4002305_4 (urease) gamma subunit K01430,K14048 - 3.5.1.5 0.000000000000000000000000000000000000000000000000000009198 190.0
TLS2_k127_4002305_5 Belongs to the urease beta subunit family K01429,K14048 - 3.5.1.5 0.000000000000000000001137 96.0
TLS2_k127_4002305_6 - - - - 0.00000000000004871 78.0
TLS2_k127_4008186_0 Major Intrinsic Protein K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004842 284.0
TLS2_k127_4008186_1 Methyltransferase type 11 K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008137 280.0
TLS2_k127_4008186_2 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000001148 195.0
TLS2_k127_4008186_3 TIGRFAM phosphate ABC transporter K02040 - - 0.000000000000000000000000005049 115.0
TLS2_k127_4019565_0 flavodoxin nitric oxide synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 394.0
TLS2_k127_4019565_1 Metallo-beta-lactamase superfamily K02238 - - 0.00000000000000000000002867 102.0
TLS2_k127_4019565_2 - - - - 0.0000005779 57.0
TLS2_k127_4023307_0 tRNA intron endonuclease, N-terminal domain K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 308.0
TLS2_k127_4023307_1 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 304.0
TLS2_k127_4023307_3 protein conserved in bacteria - - - 0.000000000000000000000000003202 119.0
TLS2_k127_4023307_5 Transcriptional regulator - - - 0.0000000000004187 73.0
TLS2_k127_4023307_6 2-nitropropane dioxygenase K00459,K02371 - 1.13.12.16,1.3.1.9 0.00000000001984 66.0
TLS2_k127_4023307_7 2-nitropropane dioxygenase K00459,K02371 - 1.13.12.16,1.3.1.9 0.00000001073 57.0
TLS2_k127_4032508_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 2.418e-198 622.0
TLS2_k127_4032508_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 544.0
TLS2_k127_4032508_10 - - - - 0.0000000002608 68.0
TLS2_k127_4032508_2 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 361.0
TLS2_k127_4032508_3 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006006 355.0
TLS2_k127_4032508_4 DNA-directed RNA polymerase K03049 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 341.0
TLS2_k127_4032508_5 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004152 268.0
TLS2_k127_4032508_6 Belongs to the UPF0218 family K09735 - - 0.000000000000000000000000000000000000000000000000008117 185.0
TLS2_k127_4032508_7 RNA-binding protein contains TRAM domain - - - 0.000000000000000000000000000000000002426 138.0
TLS2_k127_4032508_8 Ribosomal protein S30 K02983 - - 0.00000000000000000000000006154 107.0
TLS2_k127_4032508_9 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000000000000001112 98.0
TLS2_k127_4073220_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 4.401e-219 684.0
TLS2_k127_4073220_1 Lysine biosynthesis K05827 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005238 419.0
TLS2_k127_4073220_2 Cobalamin B12-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007974 411.0
TLS2_k127_4073220_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 354.0
TLS2_k127_4073220_4 glucosylceramidase activity - - - 0.00000000000000000000000000000000000000000000003001 174.0
TLS2_k127_4073220_5 lysine biosynthesis protein LysW K05826 - - 0.00000000000000000000001859 100.0
TLS2_k127_4129928_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 1.22e-201 633.0
TLS2_k127_4129928_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005804 324.0
TLS2_k127_4129928_2 archaeal coiled-coil protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004139 314.0
TLS2_k127_4129928_3 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007972 284.0
TLS2_k127_4147087_0 Aminotransferase class-V - - - 2.785e-215 671.0
TLS2_k127_4147087_1 Peptidyl-prolyl cis-trans K01802 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005529 355.0
TLS2_k127_4147087_2 Belongs to the peptidase M24B family K01262,K01271 - 3.4.11.9,3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 316.0
TLS2_k127_4147087_3 Iron-sulfur cluster assembly accessory protein K13628 - - 0.00000000000000000000000000000000000000000000000000000000004419 205.0
TLS2_k127_41872_0 Major Facilitator Superfamily - - - 6.326e-199 632.0
TLS2_k127_41872_1 Carotenoid biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000122 183.0
TLS2_k127_4187672_0 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003512 316.0
TLS2_k127_4187672_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000006401 246.0
TLS2_k127_4187672_2 - - - - 0.0000000000000000000005411 104.0
TLS2_k127_4187672_3 Diacylglycerol kinase catalytic domain - - - 0.000000000000000003994 92.0
TLS2_k127_4196570_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 556.0
TLS2_k127_4196570_1 alginic acid biosynthetic process - - - 0.0000000000001162 83.0
TLS2_k127_4196570_3 - - - - 0.00009243 46.0
TLS2_k127_4196570_4 - - - - 0.0004181 48.0
TLS2_k127_4217580_0 Radical SAM - - - 0.0 1075.0
TLS2_k127_4217580_1 Catalyzes the conversion of dihydroorotate to orotate K00226,K00254,K17723,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 548.0
TLS2_k127_4227474_0 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 1.349e-299 929.0
TLS2_k127_4227474_1 Peptidase family M1 domain K01256,K13722 - 3.4.11.2 7.621e-242 757.0
TLS2_k127_4227474_10 H subunit K02107 - - 0.000000000000000000000000000000000002232 143.0
TLS2_k127_4227474_2 Phosphate uptake regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 580.0
TLS2_k127_4227474_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 517.0
TLS2_k127_4227474_5 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.0000000000000000000000000000000000000000000000000000000000000000000000000000675 260.0
TLS2_k127_4227474_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003938 252.0
TLS2_k127_4227474_7 Patch-forming domain C2 of tRNA-guanine transglycosylase K07398 - - 0.00000000000000000000000000000000000000000000000000000000000000000613 229.0
TLS2_k127_4227474_8 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000000000000000000000000000003091 192.0
TLS2_k127_4227474_9 transcription factor, homolog of eukaryotic MBF1 K03627 - - 0.00000000000000000000000000000000000000000000000009372 180.0
TLS2_k127_4242558_1 transcriptional - - - 0.00000000000000000000000000001839 121.0
TLS2_k127_4242558_2 - - - - 0.0000000000000000000000000002268 129.0
TLS2_k127_4242558_3 copper ion binding - - - 0.00000000002537 76.0
TLS2_k127_4242558_4 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000002264 59.0
TLS2_k127_4272000_0 40-residue YVTN family beta-propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 417.0
TLS2_k127_4272000_1 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002806 314.0
TLS2_k127_4272000_10 signal transduction protein with CBS domains - - - 0.00007719 51.0
TLS2_k127_4272000_11 COG0471 Di- and tricarboxylate K14445 - - 0.0001193 46.0
TLS2_k127_4272000_2 PFAM short chain dehydrogenase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000007398 260.0
TLS2_k127_4272000_3 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000003428 222.0
TLS2_k127_4272000_4 PAC2 family K06869 - - 0.0000000000000000000000000000000000007918 145.0
TLS2_k127_4272000_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.000000000000000000000000000005055 126.0
TLS2_k127_4272000_6 PAC2 family K06869 - - 0.0000000000000000000208 94.0
TLS2_k127_4272000_7 Sodium:sulfate symporter transmembrane region K14445 - - 0.0000000000000005877 80.0
TLS2_k127_4272000_8 CBS domain - - - 0.0000001558 56.0
TLS2_k127_4272000_9 GGDEF domain - - - 0.000000648 58.0
TLS2_k127_4370933_0 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.791e-259 803.0
TLS2_k127_4370933_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000001134 162.0
TLS2_k127_4370933_2 Transcriptional regulator - - - 0.0000000000000000001127 91.0
TLS2_k127_4390928_0 - - - - 0.000000000000000000000000000000000000000000007358 169.0
TLS2_k127_4416471_0 Vitamin K epoxide reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 348.0
TLS2_k127_4416471_1 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000001422 186.0
TLS2_k127_4416471_2 membrane - - - 0.0000000000000000000000000000000000003964 147.0
TLS2_k127_4416471_3 Histidine kinase - - - 0.0000000000000000004541 96.0
TLS2_k127_4416471_4 Metallo-beta-lactamase superfamily - - - 0.00003748 50.0
TLS2_k127_4498928_2 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000000000000000001105 170.0
TLS2_k127_4498928_3 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.00000000000000000000000000000000000000004528 158.0
TLS2_k127_4498928_4 - - - - 0.0000000000000000000000000000000000000002843 153.0
TLS2_k127_4499677_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.721e-287 897.0
TLS2_k127_4499677_1 Anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 1.829e-283 885.0
TLS2_k127_4499677_10 Transcriptional regulator K07731 - - 0.00000000000000000000000000000000292 130.0
TLS2_k127_4499677_11 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02259 - - 0.0000000000000000000000000000003189 127.0
TLS2_k127_4499677_12 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000000000000000000002276 100.0
TLS2_k127_4499677_2 Thiolase, N-terminal domain K00626 - 2.3.1.9 7.007e-239 740.0
TLS2_k127_4499677_3 Carbon-nitrogen hydrolase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 374.0
TLS2_k127_4499677_4 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000767 367.0
TLS2_k127_4499677_5 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 323.0
TLS2_k127_4499677_6 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003723 300.0
TLS2_k127_4499677_7 Uracil-DNA glycosylase K21929 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000001673 267.0
TLS2_k127_4499677_8 conserved protein implicated in secretion - - - 0.0000000000000000000000000000000000000000000000000000000000000000002233 235.0
TLS2_k127_4499677_9 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.00000000000000000000000000000000000000000000000000001405 190.0
TLS2_k127_4507019_0 phosphoglycerate mutase K15635 - 5.4.2.12 1.005e-201 636.0
TLS2_k127_4507019_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 590.0
TLS2_k127_4507019_2 chromosome segregation and condensation protein ScpA K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 340.0
TLS2_k127_4507019_3 segregation and condensation protein K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001525 274.0
TLS2_k127_4507019_4 Ribosomal protein S8e K02995 - - 0.0000000000000000000000000000000000000000000000001794 181.0
TLS2_k127_4507019_5 SRP19 protein K03105 - - 0.000000000000000000000000000000000000000000003658 165.0
TLS2_k127_4507019_7 - - - - 0.000000000000000000000000000000000000008512 149.0
TLS2_k127_4507019_8 - - - - 0.000000000000000000000000000000001869 131.0
TLS2_k127_4507019_9 RNA-binding protein involved in rRNA processing K07569 - - 0.00000000000000000000000000001211 122.0
TLS2_k127_4527034_0 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 5.886e-254 790.0
TLS2_k127_4527034_1 PFAM Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 567.0
TLS2_k127_4527034_2 Fumarase C C-terminus K01744 - 4.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004463 400.0
TLS2_k127_4527034_3 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 299.0
TLS2_k127_4527034_5 Thioredoxin domain - - - 0.0000007004 55.0
TLS2_k127_4541007_0 Nudix hydrolase K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000000000000001176 213.0
TLS2_k127_4541007_2 Glycosyl transferases group 1 K16150 - 2.4.1.11 0.0000005399 62.0
TLS2_k127_4543854_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000002135 228.0
TLS2_k127_4543854_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000000000000000000006858 211.0
TLS2_k127_4543854_2 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000003279 112.0
TLS2_k127_4543854_3 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000001343 110.0
TLS2_k127_4543854_4 PFAM Glycosyl transferase family 2 - - - 0.0000002 52.0
TLS2_k127_4552724_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 3.979e-222 694.0
TLS2_k127_4552724_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009708 573.0
TLS2_k127_4552724_2 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005337 304.0
TLS2_k127_4559992_0 Membrane-bound serine protease (ClpP class) K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 511.0
TLS2_k127_4559992_1 COG0330 Membrane protease subunits stomatin prohibitin homologs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 405.0
TLS2_k127_4559992_2 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000016 123.0
TLS2_k127_4559992_3 mechanosensitive ion channel - - - 0.0000000000000000000000000001747 127.0
TLS2_k127_4559992_4 NAD(P)H-dependent FMN reductase - - - 0.000000000000000000000001822 105.0
TLS2_k127_4559992_5 TIGRFAM isocitrate dehydrogenase, NADP-dependent K00031 - 1.1.1.42 0.000000000000002926 81.0
TLS2_k127_4563218_0 ABC-type metal ion transport system periplasmic component surface adhesin K09815,K11707 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009049 374.0
TLS2_k127_4563218_1 COG1108 ABC-type Mn2 Zn2 transport systems permease components K02075,K02077,K09816,K11708,K11709 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000567 369.0
TLS2_k127_4563218_2 PFAM ABC transporter K02074,K09817,K11710 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008028 364.0
TLS2_k127_4563218_3 COG1108 ABC-type Mn2 Zn2 transport systems permease components K02075,K02077,K09816,K11708,K11709 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000044 357.0
TLS2_k127_4563218_5 iron dependent repressor - - - 0.000000000000000000000000000002461 122.0
TLS2_k127_4563218_7 iron dependent repressor - - - 0.0000002377 54.0
TLS2_k127_4571906_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1827.0
TLS2_k127_4571906_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 7.234e-230 715.0
TLS2_k127_4571906_2 ThiF family K21029 - 2.7.7.80 6.839e-227 709.0
TLS2_k127_4571906_3 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 5.839e-206 648.0
TLS2_k127_4571906_4 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 389.0
TLS2_k127_4571906_5 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000000000003268 198.0
TLS2_k127_4571906_6 - - - - 0.000000000000000000000000000000000000000000000001473 177.0
TLS2_k127_4571906_7 - - - - 0.0000000000000000000000000000000000000000000002444 173.0
TLS2_k127_4571906_8 - - - - 0.00000000000000000000000000000005507 128.0
TLS2_k127_4578118_0 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 357.0
TLS2_k127_4578118_1 Carboxylesterase family K01066 - - 0.000000000000000000000000000000000000000000000000005854 199.0
TLS2_k127_4623380_0 Initiator Replication protein - - - 0.00000000000000000000000000000000000000000000002926 186.0
TLS2_k127_4638135_2 - - - - 0.000000000000000000000001126 109.0
TLS2_k127_4638135_4 - - - - 0.000958 45.0
TLS2_k127_4758452_0 aspartate-semialdehyde dehydrogenase K00133 - 1.2.1.11 9.955e-196 614.0
TLS2_k127_4758452_1 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000006244 244.0
TLS2_k127_4758951_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008872 599.0
TLS2_k127_4758951_1 HIT domain K02503 - - 0.00000000000000000000000000000000000000000000000000000004459 199.0
TLS2_k127_4759397_0 PFAM Alcohol dehydrogenase K13979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009422 496.0
TLS2_k127_4759397_1 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001582 254.0
TLS2_k127_4759397_2 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007063 248.0
TLS2_k127_4759397_3 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000003572 185.0
TLS2_k127_4759397_4 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000004912 167.0
TLS2_k127_4759397_6 - - - - 0.00000000000000000001111 97.0
TLS2_k127_4759397_7 Winged helix-turn-helix - - - 0.00003046 49.0
TLS2_k127_4767346_0 Belongs to the complex I 49 kDa subunit family K00333 - 1.6.5.3 3.757e-229 712.0
TLS2_k127_4767346_1 NADH dehydrogenase K00337 - 1.6.5.3 4.406e-205 646.0
TLS2_k127_4767346_2 Belongs to the complex I 20 kDa subunit family K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006454 335.0
TLS2_k127_4767346_3 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001478 312.0
TLS2_k127_4767346_4 NADH ubiquinone oxidoreductase 27 kD subunit K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000005385 267.0
TLS2_k127_4767346_5 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 3 K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000005408 235.0
TLS2_k127_4767346_6 4Fe-4S binding domain K00338 - 1.6.5.3 0.00000000000000000005013 89.0
TLS2_k127_4791072_0 Phosphate uptake regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 483.0
TLS2_k127_4791072_1 PFAM TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009005 405.0
TLS2_k127_479384_0 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 470.0
TLS2_k127_479384_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 425.0
TLS2_k127_479384_11 - - - - 0.000000000000000000002643 96.0
TLS2_k127_479384_12 DNA polymerase beta domain protein region - - - 0.000004518 54.0
TLS2_k127_479384_2 Serine threonine protein kinase involved in cell cycle control K07178 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 329.0
TLS2_k127_479384_3 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 284.0
TLS2_k127_479384_4 K homology RNA-binding domain K06961 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000696 273.0
TLS2_k127_479384_5 MgtC family K07507 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002754 263.0
TLS2_k127_479384_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001061 233.0
TLS2_k127_479384_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000198 222.0
TLS2_k127_479384_8 - - - - 0.00000000000000000000000000000000000000000000000804 173.0
TLS2_k127_479384_9 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000004121 164.0
TLS2_k127_4827460_0 Cytochrome b subunit of the bc complex K00412 - - 8.587e-241 746.0
TLS2_k127_4827460_1 HMGL-like K01649 - 2.3.3.13 2.342e-223 698.0
TLS2_k127_4827460_2 Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine K05831 - - 2.439e-204 640.0
TLS2_k127_4827460_3 argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008664 586.0
TLS2_k127_4827460_4 diphthine synthase K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 457.0
TLS2_k127_4827460_5 Lysine biosynthesis K05827 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 440.0
TLS2_k127_4827460_6 low-complexity proteins - - - 0.00000000000000000000000000000000000000000000000000000002257 201.0
TLS2_k127_4827460_7 lysine biosynthesis protein LysW K05826 - - 0.00000000000000000000000007538 107.0
TLS2_k127_4827460_8 COG0723 Rieske Fe-S protein K15878 - - 0.00000000006247 71.0
TLS2_k127_4901007_0 TIGRFAM glutamine synthetase, type I K01915 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 617.0
TLS2_k127_4901007_1 zinc finger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 325.0
TLS2_k127_4901007_2 Required for chromosome condensation and partitioning - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006523 332.0
TLS2_k127_4901007_3 RNase H K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000007546 187.0
TLS2_k127_4901007_5 Sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000006844 178.0
TLS2_k127_4901007_6 - - - - 0.000000000000000000000000000000000000001312 151.0
TLS2_k127_4901007_7 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.000000000000000000000000000003359 124.0
TLS2_k127_4901007_9 - - - - 0.00000006915 55.0
TLS2_k127_4934032_0 aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 473.0
TLS2_k127_4934032_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 320.0
TLS2_k127_4934032_2 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003253 281.0
TLS2_k127_4934032_3 Rieske 2Fe-2S K05710 - - 0.000001301 50.0
TLS2_k127_501028_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 469.0
TLS2_k127_501028_1 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 365.0
TLS2_k127_501028_2 RNA binding K07581 - - 0.0000000000000000000000000000000000000000000006574 171.0
TLS2_k127_501028_4 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000006282 75.0
TLS2_k127_504583_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.029e-261 810.0
TLS2_k127_504583_1 Pterin binding enzyme K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 353.0
TLS2_k127_504583_2 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008808 322.0
TLS2_k127_504583_3 - - - - 0.0000000000000000000000000000000000000007616 150.0
TLS2_k127_504583_6 translation initiation factor activity K06996 - - 0.0000001012 56.0
TLS2_k127_5072526_0 Belongs to the arginase family K01476 - 3.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 407.0
TLS2_k127_5072526_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004402 376.0
TLS2_k127_5072526_10 integral membrane protein - - - 0.00000000000000000001051 100.0
TLS2_k127_5072526_11 - - - - 0.0000000000000044 84.0
TLS2_k127_5072526_12 Antibiotic biosynthesis monooxygenase - - - 0.00000000008905 68.0
TLS2_k127_5072526_14 2TM domain - - - 0.00001435 52.0
TLS2_k127_5072526_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000875 252.0
TLS2_k127_5072526_4 ester cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000153 209.0
TLS2_k127_5072526_5 ATP-independent chaperone mediated protein folding - - - 0.00000000000000000000000000000003934 134.0
TLS2_k127_5072526_7 - - - - 0.0000000000000000000000008723 116.0
TLS2_k127_5072526_8 Methyltransferase domain - - - 0.000000000000000000000001704 113.0
TLS2_k127_5072526_9 SnoaL-like polyketide cyclase - - - 0.00000000000000000000003389 106.0
TLS2_k127_5130384_0 synthetase (class II) K01880 - 6.1.1.14 9.147e-253 786.0
TLS2_k127_5130384_1 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 8.011e-215 673.0
TLS2_k127_5130384_2 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 522.0
TLS2_k127_5130384_3 Ribosomal protein L15E K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 286.0
TLS2_k127_5130384_5 Fumarase C C-terminus K01744 - 4.3.1.1 0.000000000005037 67.0
TLS2_k127_5201808_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005627 529.0
TLS2_k127_5201808_1 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 433.0
TLS2_k127_5201808_10 ERCC4 domain K10848 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006686 304.0
TLS2_k127_5201808_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009237 281.0
TLS2_k127_5201808_12 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003002 248.0
TLS2_k127_5201808_13 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000000000000000000003457 238.0
TLS2_k127_5201808_14 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000000000000000000000000000000000000000000000002775 181.0
TLS2_k127_5201808_15 PIN domain of ribonuclease K07060 - - 0.00000000000000000000000000000000000000000001294 167.0
TLS2_k127_5201808_16 Domain of unknown function (DUF2024) - - - 0.00000000000000000000000000000000000000000003893 163.0
TLS2_k127_5201808_17 - - - - 0.0000000000000000000000000000000000000003206 151.0
TLS2_k127_5201808_18 Ribosomal L37ae protein family K02921 - - 0.00000000000000000000000000000000005079 134.0
TLS2_k127_5201808_2 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 430.0
TLS2_k127_5201808_20 60S ribosomal protein L18 K02883 - - 0.000002667 54.0
TLS2_k127_5201808_21 AhpC/TSA family - - - 0.00001655 49.0
TLS2_k127_5201808_3 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006241 418.0
TLS2_k127_5201808_4 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004845 409.0
TLS2_k127_5201808_5 DNA-directed RNA polymerase, alpha subunit 40 kD subunit K03047 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 372.0
TLS2_k127_5201808_6 ferredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007994 361.0
TLS2_k127_5201808_7 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 349.0
TLS2_k127_5201808_8 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 324.0
TLS2_k127_5201808_9 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006277 316.0
TLS2_k127_5236322_0 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 455.0
TLS2_k127_5236322_1 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000002068 119.0
TLS2_k127_5251329_0 phospholipase Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001313 244.0
TLS2_k127_5257748_0 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008969 533.0
TLS2_k127_5257748_1 Probable cobalt transporter subunit (CbtA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006206 282.0
TLS2_k127_5257748_2 Domain of unknown function (DUF4443) - - - 0.00000000000000000000000000000000000000000000000000000000000000000003962 237.0
TLS2_k127_5257748_3 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000001833 171.0
TLS2_k127_5257748_4 Transcriptional regulator - - - 0.000000000000000000006122 93.0
TLS2_k127_5257748_5 Probable cobalt transporter subunit (CbtB) - - - 0.0000000000000000642 89.0
TLS2_k127_5263871_0 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 6.595e-244 757.0
TLS2_k127_5263871_1 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 1.256e-239 749.0
TLS2_k127_5263871_10 NADH ubiquinone oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000005628 216.0
TLS2_k127_5263871_11 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000008301 215.0
TLS2_k127_5263871_12 zinc-ribbon domain - - - 0.00000000000000000000000000000000000000000000000000000000006658 206.0
TLS2_k127_5263871_13 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.21.7 0.0000000000000000000000000000000000000000000000000000001418 200.0
TLS2_k127_5263871_15 Bacterial regulatory protein, arsR family - - - 0.00000000000000000000000000000000000000000003451 162.0
TLS2_k127_5263871_16 Membrane - - - 0.0000000000000000000000000000000000000000002333 171.0
TLS2_k127_5263871_17 - - - - 0.000000000000000000000000000000000000001206 147.0
TLS2_k127_5263871_18 PFAM tRNA synthetases class I (C) catalytic domain K01883 - 6.1.1.16 0.00000000000000000000000000000235 122.0
TLS2_k127_5263871_2 DEAD DEAH box helicase K05592 - 3.6.4.13 1.141e-206 653.0
TLS2_k127_5263871_20 - - - - 0.00000000000000000000000004887 110.0
TLS2_k127_5263871_21 - - - - 0.000000000000000000002087 97.0
TLS2_k127_5263871_22 - - - - 0.0000000000001476 73.0
TLS2_k127_5263871_3 AhpC/TSA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009219 494.0
TLS2_k127_5263871_5 Methyltransferase type 11 K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008344 407.0
TLS2_k127_5263871_6 cytochrome c biogenesis protein K06196 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 378.0
TLS2_k127_5263871_7 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003105 272.0
TLS2_k127_5263871_8 PFAM Like-Sm ribonucleoprotein, core - - - 0.000000000000000000000000000000000000000000000000000000000000000000008215 235.0
TLS2_k127_5263871_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001451 234.0
TLS2_k127_5273351_0 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002534 269.0
TLS2_k127_5273351_2 Circadian clock protein KaiC - - - 0.000000000000000000000000002529 119.0
TLS2_k127_5284450_0 Methionine synthase K00548 - 2.1.1.13 0.0 1316.0
TLS2_k127_5284450_1 PFAM tRNA synthetase, class II (D, K and N) K01893 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 9.274e-226 705.0
TLS2_k127_5284450_2 Zinc-binding dehydrogenase K13979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 599.0
TLS2_k127_5284450_3 homocysteine S-methyltransferase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 501.0
TLS2_k127_5284450_4 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001782 273.0
TLS2_k127_5284450_5 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.00000004211 54.0
TLS2_k127_5284450_6 TPR repeat K07114 - - 0.000007581 49.0
TLS2_k127_5284450_7 Protein of unknown function (DUF1326) - - - 0.000007943 48.0
TLS2_k127_5407021_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 4.05e-236 754.0
TLS2_k127_5407021_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 548.0
TLS2_k127_5407021_10 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000005312 130.0
TLS2_k127_5407021_11 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000003074 100.0
TLS2_k127_5407021_12 - - - - 0.000000000000001056 81.0
TLS2_k127_5407021_13 - - - - 0.000000000000003592 78.0
TLS2_k127_5407021_14 Ferritin K03594 - 1.16.3.1 0.00000000009909 70.0
TLS2_k127_5407021_2 Transcriptional regulator K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 368.0
TLS2_k127_5407021_3 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 364.0
TLS2_k127_5407021_4 PFAM regulatory protein TetR K03577,K18939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008466 314.0
TLS2_k127_5407021_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002206 258.0
TLS2_k127_5407021_7 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000001074 236.0
TLS2_k127_5407021_8 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000001393 161.0
TLS2_k127_5407021_9 DinB family - - - 0.000000000000000000000000000000000000005588 148.0
TLS2_k127_5423403_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 5.836e-286 886.0
TLS2_k127_5423403_1 PFAM tRNA synthetases class I (C) catalytic domain K01883 - 6.1.1.16 1.207e-216 680.0
TLS2_k127_5423403_2 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009711 579.0
TLS2_k127_5423403_3 NAD(P)H-dependent FMN reductase K00299 - 1.5.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 302.0
TLS2_k127_5423403_4 Cytidylyltransferase-like K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 289.0
TLS2_k127_5423403_6 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K00363,K15762 - 1.7.1.15 0.00000000000000000000000000000000000000000000000002345 179.0
TLS2_k127_5423403_7 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.000000000002177 68.0
TLS2_k127_5424944_0 archaeal coiled-coil protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008294 402.0
TLS2_k127_5424944_1 Belongs to the MenA family. Type 1 subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001976 271.0
TLS2_k127_5424944_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001277 251.0
TLS2_k127_5424944_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000253 250.0
TLS2_k127_5424944_4 Methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000001244 235.0
TLS2_k127_5424944_5 4-hydroxybenzoate synthetase (chorismate lyase) K03181,K06984 - 2.4.2.54,4.1.3.40 0.0000000000000000000000000000228 123.0
TLS2_k127_5424944_6 Transcriptional regulator - - - 0.000000000000007866 78.0
TLS2_k127_5424944_8 Transcriptional regulator - - - 0.00008191 48.0
TLS2_k127_5475504_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01870 - 6.1.1.5 0.0 1654.0
TLS2_k127_5475504_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 4.319e-281 880.0
TLS2_k127_5475504_10 - - - - 0.00000000000000000003086 90.0
TLS2_k127_5475504_11 Transcriptional regulator - - - 0.0000000001983 65.0
TLS2_k127_5475504_2 Initiation factor K03242 - - 6.005e-234 727.0
TLS2_k127_5475504_3 AAA domain (Cdc48 subfamily) - - - 4.377e-223 696.0
TLS2_k127_5475504_4 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 314.0
TLS2_k127_5475504_5 conserved protein implicated in secretion - - - 0.00000000000000000000000000000000000000000000000000000000000000001173 231.0
TLS2_k127_5475504_6 Dual specificity phosphatase, catalytic domain K14165 - 3.1.3.16,3.1.3.48 0.0000000000000000000000000000000000000000000000000000000000000008322 222.0
TLS2_k127_5475504_7 Nucleotide binding protein, PINc K07158 - - 0.00000000000000000000000000000000000000000000000008548 180.0
TLS2_k127_5475504_8 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.0000000000000000000000000000000000000000000000006831 177.0
TLS2_k127_5475504_9 - - - - 0.00000000000000000000001549 100.0
TLS2_k127_5526166_0 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000002301 220.0
TLS2_k127_5526166_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000001807 178.0
TLS2_k127_5526166_3 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.000004603 53.0
TLS2_k127_5551138_0 RNase L inhibitor, RLI K06174 - - 0.0 1038.0
TLS2_k127_5551138_1 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 3.562e-304 939.0
TLS2_k127_5551138_10 Met-10+ like-protein K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000828 376.0
TLS2_k127_5551138_11 oxidoreductase FAD NAD(P)-binding K00523,K00528 - 1.17.1.1,1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 362.0
TLS2_k127_5551138_12 ATPase family associated with various cellular activities (AAA) K04748 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 352.0
TLS2_k127_5551138_13 Transketolase, central region K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008858 334.0
TLS2_k127_5551138_14 FR47-like protein K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 298.0
TLS2_k127_5551138_15 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005822 277.0
TLS2_k127_5551138_16 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000759 269.0
TLS2_k127_5551138_17 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000005302 265.0
TLS2_k127_5551138_18 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001301 252.0
TLS2_k127_5551138_19 Signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000006274 244.0
TLS2_k127_5551138_2 von Willebrand factor (vWF) type A domain - - - 7.813e-274 848.0
TLS2_k127_5551138_21 - - - - 0.00000000000000000000000000000000000000000000000002666 182.0
TLS2_k127_5551138_22 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000000000000000006214 138.0
TLS2_k127_5551138_23 - - - - 0.00000000000000000000000000005823 118.0
TLS2_k127_5551138_24 - - - - 0.0000000000000000000000000001387 120.0
TLS2_k127_5551138_3 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 3.178e-260 808.0
TLS2_k127_5551138_4 NOSIC (NUC001) domain K14564 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000835 580.0
TLS2_k127_5551138_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family K00555 - 2.1.1.215,2.1.1.216 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004508 512.0
TLS2_k127_5551138_6 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 411.0
TLS2_k127_5551138_7 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 409.0
TLS2_k127_5551138_8 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 379.0
TLS2_k127_5551138_9 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 376.0
TLS2_k127_5590672_0 Carbamoyl-phosphate synthase L chain K18603 - 6.4.1.2,6.4.1.3 1.728e-282 872.0
TLS2_k127_5590672_1 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K18604 - 2.1.3.15,6.4.1.2,6.4.1.3 1.259e-236 741.0
TLS2_k127_5590672_2 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 4.132e-200 647.0
TLS2_k127_5590672_3 biotin carboxyl carrier K00627,K01571,K15037,K18605 - 2.3.1.12,4.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004781 293.0
TLS2_k127_5590672_4 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000002487 229.0
TLS2_k127_5590672_5 Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000001776 229.0
TLS2_k127_5590672_6 PFAM Creatininase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000001594 220.0
TLS2_k127_5590672_7 Heavy-metal-associated domain K01533 - 3.6.3.4 0.000000000000000000000000000007164 120.0
TLS2_k127_5590672_8 - K03646 - - 0.000000000000000000004449 94.0
TLS2_k127_5598104_0 Large family of predicted nucleotide-binding domains K06865 - - 3.115e-309 956.0
TLS2_k127_5598104_1 Protein of unknown function (DUF1512) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 558.0
TLS2_k127_5598104_10 metalloendopeptidase activity - - - 0.000000000000000006038 85.0
TLS2_k127_5598104_2 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 466.0
TLS2_k127_5598104_3 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 374.0
TLS2_k127_5598104_4 Belongs to the complex I 20 kDa subunit family K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 292.0
TLS2_k127_5598104_5 Peptidase M10A and M12B matrixin and adamalysin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001025 269.0
TLS2_k127_5598104_6 iron dependent repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002268 254.0
TLS2_k127_5598104_7 - - - - 0.00000000000000000000000000000000000000000000000000000000003157 217.0
TLS2_k127_5598104_8 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000000001771 183.0
TLS2_k127_5598104_9 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000000000000000000001205 151.0
TLS2_k127_5598676_0 Domain of unknown function (DUF929) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006311 291.0
TLS2_k127_5598676_1 ribosomal protein K02866 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000127 283.0
TLS2_k127_5598676_2 tRNA intron endonuclease, N-terminal domain K01170 - 4.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002508 270.0
TLS2_k127_5598676_3 COG2406 Protein distantly related to bacterial ferritins K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000005154 263.0
TLS2_k127_5598676_4 COG4618 ABC-type protease lipase transport system, ATPase and permease components - - - 0.0000000000000000000000000000000000000000001588 162.0
TLS2_k127_5598676_5 zinc finger - - - 0.00000000000000000000001444 101.0
TLS2_k127_5598676_6 - - - - 0.0000000000001108 72.0
TLS2_k127_5598676_7 - - - - 0.0000000000006027 71.0
TLS2_k127_56058_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.499e-280 868.0
TLS2_k127_56058_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009013 598.0
TLS2_k127_56058_11 YHS domain - - - 0.00000000000000000003418 90.0
TLS2_k127_56058_2 LAO AO transport system ATPase K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003453 465.0
TLS2_k127_56058_3 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 409.0
TLS2_k127_56058_4 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 402.0
TLS2_k127_56058_5 PFAM Ammonia monooxygenase methane monooxygenase, subunit C K10946 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 377.0
TLS2_k127_56058_6 Ferritin-like domain K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007273 371.0
TLS2_k127_56058_7 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000001206 246.0
TLS2_k127_56058_8 Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000381 228.0
TLS2_k127_56058_9 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K05710 - - 0.0000000000000000000000000000000000000000000001158 170.0
TLS2_k127_5618593_0 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 496.0
TLS2_k127_5618593_1 DnaJ central domain K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 430.0
TLS2_k127_5618593_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005003 311.0
TLS2_k127_5618593_3 thioesterase - - - 0.00000000000000000000000000000000000000000000000000000000000004249 215.0
TLS2_k127_5618593_5 - - - - 0.000000000000000000000000000000009343 128.0
TLS2_k127_5618593_6 Binds to the 23S rRNA K02929 - - 0.00000000000000000000000000000001074 127.0
TLS2_k127_5652589_0 Sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 405.0
TLS2_k127_5652589_1 Pyridoxamine 5'-phosphate K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000808 323.0
TLS2_k127_5652589_2 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000000000000000000000000000002535 219.0
TLS2_k127_5671209_0 TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005813 540.0
TLS2_k127_5671209_1 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 509.0
TLS2_k127_5671209_3 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.0000000000000001466 93.0
TLS2_k127_5671209_4 SnoaL-like domain - - - 0.00000007408 57.0
TLS2_k127_5683362_0 PFAM Iron-containing alcohol dehydrogenase K18602 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009945 574.0
TLS2_k127_5683362_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 375.0
TLS2_k127_5683362_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 333.0
TLS2_k127_5683362_3 Cytochrome oxidase assembly protein K02259 - - 0.000000000000000000000000000000000000000000000000000000000000006603 219.0
TLS2_k127_5683362_4 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000000000319 191.0
TLS2_k127_5700846_0 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.0000000000000000000000004827 108.0
TLS2_k127_5728460_0 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.00000000000000001196 97.0
TLS2_k127_5728460_1 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000009395 75.0
TLS2_k127_5818674_0 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 492.0
TLS2_k127_5818674_1 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003444 414.0
TLS2_k127_5818674_2 Pirin C-terminal cupin domain K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 411.0
TLS2_k127_5818674_3 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001142 273.0
TLS2_k127_5818674_4 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000004675 255.0
TLS2_k127_5818674_5 Antibiotic biosynthesis monooxygenase K09932 - - 0.000000000000000000000000000000000000000000000000000000000000000003406 233.0
TLS2_k127_5818674_6 Belongs to the UPF0201 family K09736 - - 0.00000000000000000000000000000000000000000000000000000000000188 211.0
TLS2_k127_5818674_7 - - - - 0.0000000000000000003946 87.0
TLS2_k127_5820538_0 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 490.0
TLS2_k127_5820538_1 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004984 383.0
TLS2_k127_5820538_2 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 378.0
TLS2_k127_5820538_3 - - - - 0.000000000000000000000000000000000000000002136 157.0
TLS2_k127_590274_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 3.322e-251 786.0
TLS2_k127_590274_1 Domain of unknown function (DUF4162) K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009244 319.0
TLS2_k127_590274_2 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000007008 196.0
TLS2_k127_590274_3 PFAM beta-lactamase domain protein K02238 - - 0.000000000000000000000000000000000000000000000001889 189.0
TLS2_k127_590274_4 over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. Also displays oxidoreductase (thioredoxin) activity K01456 GO:0000224,GO:0001558,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006457,GO:0006464,GO:0006508,GO:0006511,GO:0006515,GO:0006516,GO:0006517,GO:0006807,GO:0006950,GO:0007154,GO:0007267,GO:0007275,GO:0007399,GO:0007494,GO:0007495,GO:0008150,GO:0008152,GO:0008361,GO:0009056,GO:0009057,GO:0009100,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010498,GO:0010556,GO:0010646,GO:0010647,GO:0010721,GO:0010769,GO:0010771,GO:0010975,GO:0010977,GO:0015035,GO:0015036,GO:0016043,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016787,GO:0016810,GO:0016811,GO:0019219,GO:0019222,GO:0019538,GO:0019725,GO:0019941,GO:0022008,GO:0022603,GO:0022604,GO:0023051,GO:0023052,GO:0023056,GO:0030154,GO:0030163,GO:0030246,GO:0030308,GO:0030433,GO:0030510,GO:0030513,GO:0031323,GO:0031326,GO:0031344,GO:0031345,GO:0032501,GO:0032502,GO:0032535,GO:0033554,GO:0034976,GO:0035295,GO:0036211,GO:0036503,GO:0040008,GO:0042221,GO:0042592,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0045595,GO:0045596,GO:0045664,GO:0045665,GO:0045926,GO:0047134,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048565,GO:0048583,GO:0048584,GO:0048638,GO:0048640,GO:0048670,GO:0048671,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050768,GO:0050770,GO:0050771,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051093,GO:0051128,GO:0051129,GO:0051171,GO:0051239,GO:0051241,GO:0051252,GO:0051603,GO:0051716,GO:0051960,GO:0051961,GO:0055114,GO:0055123,GO:0060255,GO:0060284,GO:0061387,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0080090,GO:0090066,GO:0090092,GO:0090100,GO:0090287,GO:0120035,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1903506,GO:2000026,GO:2000112,GO:2001141 3.5.1.52 0.00000000000000000000000000000001502 137.0
TLS2_k127_590274_5 - - - - 0.000000000000000000000006445 104.0
TLS2_k127_591685_0 Belongs to the complex I 49 kDa subunit family K00333 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009136 530.0
TLS2_k127_591685_2 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000097 292.0
TLS2_k127_591685_3 Enoyl-(Acyl carrier protein) reductase K00034,K00038,K00046 - 1.1.1.47,1.1.1.53,1.1.1.69 0.000000000000000000000000000000000000000000000000000000000001446 218.0
TLS2_k127_591685_4 Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a K00148 - 1.2.1.46 0.0000000000000000000000000000000000000000000000000000000004586 203.0
TLS2_k127_591685_5 HAD-superfamily hydrolase, subfamily IA, variant 3 K01091,K01838,K07025 - 3.1.3.18,5.4.2.6 0.000000000000000000000000000000000000000000000000002256 190.0
TLS2_k127_591685_6 - - - - 0.00000000000000000001168 93.0
TLS2_k127_591685_7 protein conserved in bacteria - - - 0.000000000000001405 83.0
TLS2_k127_591685_8 protein conserved in bacteria - - - 0.0000000000007203 71.0
TLS2_k127_5963891_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 579.0
TLS2_k127_5963891_1 ATPase family associated with various cellular activities (AAA) K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005401 560.0
TLS2_k127_5963891_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 353.0
TLS2_k127_5963891_3 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000122 275.0
TLS2_k127_5963891_4 - - - - 0.000000000000000000001444 99.0
TLS2_k127_5963891_5 response regulator, receiver K07668,K07669 - - 0.00000000000000000001858 96.0
TLS2_k127_5963891_6 Transcriptional regulator - - - 0.000000001741 63.0
TLS2_k127_6038212_0 RNA-metabolising metallo-beta-lactamase K07041 - - 8.707e-282 878.0
TLS2_k127_6038212_1 phenylalanyl-tRNA synthetase, beta subunit K01890 - 6.1.1.20 8.825e-225 708.0
TLS2_k127_6038212_2 Thiamine biosynthesis protein (ThiI) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 532.0
TLS2_k127_6038212_3 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 514.0
TLS2_k127_6038212_4 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 317.0
TLS2_k127_6038212_5 Protein of unknown function DUF99 K09120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001645 245.0
TLS2_k127_6038212_6 Pfam:DUF552 K09152 - - 0.000000003769 61.0
TLS2_k127_6060968_0 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001552 265.0
TLS2_k127_6060968_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007238 261.0
TLS2_k127_6060968_2 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000000001137 145.0
TLS2_k127_6060968_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000169 87.0
TLS2_k127_6060968_5 Circadian clock protein KaiC - - - 0.0000000000000000847 84.0
TLS2_k127_6060968_7 Histidine kinase A domain protein - - - 0.000000000000004681 82.0
TLS2_k127_6060968_8 PFAM regulatory protein AsnC Lrp family - - - 0.0000000003441 64.0
TLS2_k127_606550_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 2315.0
TLS2_k127_606550_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K13798 - 2.7.7.6 0.0 2149.0
TLS2_k127_606550_2 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009508 579.0
TLS2_k127_606550_3 NGG1p interacting factor 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 437.0
TLS2_k127_606550_4 Participates in transcription termination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002852 256.0
TLS2_k127_606550_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000000000000000000000004066 150.0
TLS2_k127_606550_6 peptidyl-tyrosine sulfation - - - 0.000000000000000002181 93.0
TLS2_k127_606550_7 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.00000007741 57.0
TLS2_k127_606550_8 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000001912 53.0
TLS2_k127_6085150_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1227.0
TLS2_k127_6085150_1 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 5.515e-257 800.0
TLS2_k127_6085150_10 Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity K08096 - 3.5.4.29 0.000000000000000000000000000000000000000000000000000000000000000000000002335 251.0
TLS2_k127_6085150_11 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000002311 151.0
TLS2_k127_6085150_12 - - - - 0.00000000000000000000000000000004067 134.0
TLS2_k127_6085150_15 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0000000157 58.0
TLS2_k127_6085150_16 TIGRFAM riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.00002976 46.0
TLS2_k127_6085150_2 Aldehyde dehydrogenase family K00294 - 1.2.1.88 7.917e-257 799.0
TLS2_k127_6085150_3 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007165 518.0
TLS2_k127_6085150_4 Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 393.0
TLS2_k127_6085150_5 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 353.0
TLS2_k127_6085150_6 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009651 331.0
TLS2_k127_6085150_7 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 304.0
TLS2_k127_6085150_8 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001857 268.0
TLS2_k127_6085150_9 RibD C-terminal domain K14654 - 1.1.1.302 0.000000000000000000000000000000000000000000000000000000000000000000000000009561 258.0
TLS2_k127_6135352_0 Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 528.0
TLS2_k127_6135352_1 TIGRFAM precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 402.0
TLS2_k127_6135352_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002694 255.0
TLS2_k127_6135352_3 - - - - 0.0000000000000000000000000000000000000000000000002579 182.0
TLS2_k127_62412_1 alginic acid biosynthetic process K09483 - 4.2.1.118 0.00000000000000000000000000007148 132.0
TLS2_k127_6370499_1 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.0000000000000000000000000000000000000000000000006256 178.0
TLS2_k127_6370499_2 ZIP Zinc transporter K07238 - - 0.000000000000000000000000000007281 128.0
TLS2_k127_6484071_0 ester cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000003246 226.0
TLS2_k127_6484071_1 Protein of unknown function (DUF4242) - - - 0.0000000000000000000004137 98.0
TLS2_k127_6539972_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000737 266.0
TLS2_k127_6539972_1 PFAM phosphoesterase, PA-phosphatase related K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000001728 236.0
TLS2_k127_6539972_2 zinc finger - - - 0.000000000000945 70.0
TLS2_k127_6539972_3 - - - - 0.000000009679 57.0
TLS2_k127_655463_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007574 582.0
TLS2_k127_655463_1 Diphthamide biosynthesis K07561 - 2.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008773 555.0
TLS2_k127_655463_10 Transcriptional regulator, asnc family K03718 - - 0.00000000000000000001523 97.0
TLS2_k127_655463_2 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 548.0
TLS2_k127_655463_3 PP-loop family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 469.0
TLS2_k127_655463_4 Protein of unknown function DUF126 K09128 - - 0.000000000000000000000000000000000000000000000003448 177.0
TLS2_k127_655463_5 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.00000000000000000000000000000000000000000000008883 172.0
TLS2_k127_655463_6 - - - - 0.0000000000000000000000000000000000000000005236 159.0
TLS2_k127_655463_7 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions - - - 0.000000000000000000000000000000000000002431 148.0
TLS2_k127_655463_8 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000003521 124.0
TLS2_k127_655463_9 - - - - 0.00000000000000000000000000000322 120.0
TLS2_k127_668018_0 Hydroxymethylglutaryl-coenzyme A synthase N terminal K01641 - 2.3.3.10 2.716e-264 818.0
TLS2_k127_668018_1 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 1.699e-203 640.0
TLS2_k127_668018_2 Domain of unknown function (DUF2024) - - - 0.000000000000000000000428 95.0
TLS2_k127_6765422_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000009316 282.0
TLS2_k127_6765422_1 oxidation-reduction process K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000004928 166.0
TLS2_k127_6765422_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000001865 133.0
TLS2_k127_6765422_4 response regulator, receiver - - - 0.000000000000000000000000002796 118.0
TLS2_k127_6784710_0 Heat shock 70 kDa protein K04043 - - 0.0 1044.0
TLS2_k127_6784710_1 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000000000000000006395 222.0
TLS2_k127_6784710_2 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000000000000000000000003573 205.0
TLS2_k127_6784710_3 DnaJ central domain K03686 - - 0.000000000000000000000000000000000000000000000000000003789 192.0
TLS2_k127_6784710_4 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000004779 148.0
TLS2_k127_6787162_0 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000002957 212.0
TLS2_k127_6787162_1 PFAM glycosyl transferase group 1 - - - 0.00000000000007791 84.0
TLS2_k127_6787162_2 4Fe-4S binding domain K00338 - 1.6.5.3 0.00000000000159 67.0
TLS2_k127_6795389_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 1.835e-233 731.0
TLS2_k127_6795389_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 464.0
TLS2_k127_6795389_2 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 373.0
TLS2_k127_6795389_3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007233 351.0
TLS2_k127_6795389_5 - - - - 0.00000000000000000000000000000000000000000000000008548 180.0
TLS2_k127_6795389_8 - - - - 0.000000000000000000001403 97.0
TLS2_k127_6804739_0 3-isopropylmalate dehydratase, large subunit K01703 - 4.2.1.33,4.2.1.35 4.126e-269 833.0
TLS2_k127_6804739_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 2.666e-218 684.0
TLS2_k127_6804739_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006491 395.0
TLS2_k127_6804739_3 3-isopropylmalate dehydratase, small subunit K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003693 323.0
TLS2_k127_6804739_4 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) K05967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 309.0
TLS2_k127_6804739_5 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000001265 222.0
TLS2_k127_6809339_0 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 551.0
TLS2_k127_6809339_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003591 479.0
TLS2_k127_6809339_2 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 362.0
TLS2_k127_6809339_3 A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products - - - 0.000000000000000000000000000000000000000000000000000000000000000000001609 240.0
TLS2_k127_6809339_4 Translin family K07477 - - 0.0000000000000000000000000000000000000000000000000000000001527 206.0
TLS2_k127_6809339_5 Putative tRNA binding domain K06878 - - 0.0000000000000000000000000000000000000000006744 160.0
TLS2_k127_6829918_0 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000168 86.0
TLS2_k127_6829918_2 Transcriptional regulator - - - 0.000173 47.0
TLS2_k127_6870831_0 resistance protein K14166 - - 0.0 1062.0
TLS2_k127_6870831_2 - - - - 0.000000000000000000000000000000000000000000000000003546 186.0
TLS2_k127_6870831_3 - - - - 0.0000000000000000000000000000418 121.0
TLS2_k127_6870831_4 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.000000000000003996 81.0
TLS2_k127_6870831_5 PFAM blue (type 1) copper domain protein - - - 0.00000000000001809 76.0
TLS2_k127_6870831_6 dehydratase K01724 - 4.2.1.96 0.00000001905 65.0
TLS2_k127_6882827_0 FeS assembly protein SufB K09014 - - 3.556e-291 895.0
TLS2_k127_6882827_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 2.529e-236 737.0
TLS2_k127_6882827_10 AhpC/TSA antioxidant enzyme K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000007766 237.0
TLS2_k127_6882827_11 of nitrite reductase and ring-hydroxylating K05710 - - 0.000000000000000000000000000000000000000000005515 165.0
TLS2_k127_6882827_13 ABC-type antimicrobial peptide transport system, ATPase component K02003,K09810 - - 0.00000001195 56.0
TLS2_k127_6882827_2 FeS assembly protein SufD K09014,K09015 - - 1.063e-226 710.0
TLS2_k127_6882827_3 modulator of DNA gyrase K03568 - - 1.286e-215 678.0
TLS2_k127_6882827_4 geranylgeranyl reductase K17830 - 1.3.1.101,1.3.7.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 604.0
TLS2_k127_6882827_5 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000681 588.0
TLS2_k127_6882827_6 AhpC/TSA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 545.0
TLS2_k127_6882827_7 ABC-type transport system, involved in lipoprotein release, permease component K02004 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 541.0
TLS2_k127_6882827_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005876 291.0
TLS2_k127_6882827_9 SUF system FeS assembly protein K04488 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009735 261.0
TLS2_k127_699169_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007742 603.0
TLS2_k127_699169_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 470.0
TLS2_k127_699169_2 Glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006227 313.0
TLS2_k127_7011382_0 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 1.082e-246 768.0
TLS2_k127_7011382_1 PFAM Permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009171 595.0
TLS2_k127_7011382_2 Phosphomethylpyrimidine kinase K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 548.0
TLS2_k127_7011382_3 nucleotidyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 515.0
TLS2_k127_7011382_4 Nucleotidyl transferase K00966 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008615 408.0
TLS2_k127_7011382_5 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000525 249.0
TLS2_k127_7011382_6 - - - - 0.000000000000000000000000000000000000106 146.0
TLS2_k127_7051040_0 MOFRL family K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 455.0
TLS2_k127_7051040_1 UbiA prenyltransferase K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003308 418.0
TLS2_k127_7051040_2 biotin-(Acetyl-CoA-carboxylase) ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000571 329.0
TLS2_k127_7051040_3 Uncharacterized conserved protein (DUF2203) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001179 237.0
TLS2_k127_7051040_4 Aldo/keto reductase family - - - 0.0000000000000000000007396 97.0
TLS2_k127_7088215_0 COG0433 Predicted ATPase K06915 - - 2.291e-254 790.0
TLS2_k127_7088215_1 PFAM NurA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 452.0
TLS2_k127_7088215_4 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000001256 161.0
TLS2_k127_7088215_5 Lamin Tail Domain - - - 0.000000000000000000000000000000001437 132.0
TLS2_k127_7088215_7 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 0.0000000000000000006234 92.0
TLS2_k127_7088215_8 Transcriptional regulator - - - 0.000000000005642 70.0
TLS2_k127_7162526_0 ABC-type transport system, involved in lipoprotein release, permease component K02004 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 407.0
TLS2_k127_7162526_1 ABC-type antimicrobial peptide transport system, ATPase component K02003,K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 289.0
TLS2_k127_7162526_2 - - - - 0.00000000000000000000000000000000000000000000007343 171.0
TLS2_k127_7162526_3 4Fe-4S single cluster domain - - - 0.0000000000000000000000001034 118.0
TLS2_k127_7192564_0 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001237 287.0
TLS2_k127_7192564_1 - - - - 0.00000000000000000000000000000000000000000000000000000000001104 213.0
TLS2_k127_7194927_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 8.219e-223 698.0
TLS2_k127_7194927_1 DHHA1 domain K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 468.0
TLS2_k127_7194927_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 422.0
TLS2_k127_7194927_3 glutamine amidotransferase K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000002704 231.0
TLS2_k127_7194927_4 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000002418 217.0
TLS2_k127_7194927_5 - - - - 0.0004317 43.0
TLS2_k127_719597_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 468.0
TLS2_k127_719597_1 PFAM Inosine uridine-preferring nucleoside hydrolase K01250 - - 0.000000000000000000000000000000000009511 143.0
TLS2_k127_719597_2 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.0000000000000000000000000000000004429 143.0
TLS2_k127_7196175_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006788 274.0
TLS2_k127_7196175_1 factor TFIIB K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004711 254.0
TLS2_k127_7196175_2 FUN14 family - - - 0.00000000000000002055 86.0
TLS2_k127_7243715_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 7.9e-213 663.0
TLS2_k127_7243715_1 Tetrapyrrole (Corrin/Porphyrin) Methylases K05936 - 2.1.1.133,2.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 427.0
TLS2_k127_7243715_2 conserved protein implicated in secretion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004393 249.0
TLS2_k127_7243715_3 Tetrapyrrole (Corrin/Porphyrin) Methylases K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000000000000000006297 244.0
TLS2_k127_7243715_4 DnaJ-class molecular chaperone with C-terminal Zn finger domain - - - 0.00000000000000000000000000000000000000000000000000000000000004878 219.0
TLS2_k127_7243715_5 HD domain K00951,K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000000000000000000003132 178.0
TLS2_k127_7243715_7 endonuclease activity K07451 - - 0.0000000000000002567 80.0
TLS2_k127_7243715_8 - - - - 0.0000000000000004993 85.0
TLS2_k127_7253775_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 6.48e-237 736.0
TLS2_k127_7253775_1 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005551 260.0
TLS2_k127_7253775_2 mttA/Hcf106 family K03116 - - 0.0000000000000000000000000000002465 126.0
TLS2_k127_7294275_0 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006011 273.0
TLS2_k127_7294275_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000001003 149.0
TLS2_k127_7296004_0 membrane protein domain - - - 0.000000000000000000000000000000000000000000000009762 175.0
TLS2_k127_7296004_1 membrane protein domain - - - 0.0000000000000000000000000000000000226 143.0
TLS2_k127_731807_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 439.0
TLS2_k127_731807_1 methylase K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 432.0
TLS2_k127_731807_10 NAD(P)H-dependent FMN reductase - - - 0.0000000000000000004713 88.0
TLS2_k127_731807_11 - - - - 0.000000000005564 75.0
TLS2_k127_731807_2 DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005369 399.0
TLS2_k127_731807_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 365.0
TLS2_k127_731807_4 Cytidylyltransferase-like K02201 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000003556 197.0
TLS2_k127_731807_8 RNA methyltransferase, TrmH family, group 1 - - - 0.00000000000000000000000008037 117.0
TLS2_k127_731807_9 ferredoxin - - - 0.00000000000000000000005437 97.0
TLS2_k127_763764_0 Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 524.0
TLS2_k127_763764_1 carbohydrate metabolic process - - - 0.00000000000000000001671 102.0
TLS2_k127_763764_2 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000107 62.0
TLS2_k127_763764_3 - - - - 0.00004045 52.0
TLS2_k127_806420_0 Type III restriction enzyme, res subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 538.0
TLS2_k127_806420_1 O-methyltransferase, family 2 K09846 - 2.1.1.210 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005693 375.0
TLS2_k127_807331_0 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily K05829 - - 1.046e-221 688.0
TLS2_k127_807331_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K05830 - - 1.697e-208 653.0
TLS2_k127_807331_2 Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) K05828 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 442.0
TLS2_k127_807331_3 - - - - 0.000000000000000000000000000000000000000000000000000005013 192.0
TLS2_k127_807331_4 helix_turn_helix ASNC type - - - 0.0000000000000000000000000000000000000001718 154.0
TLS2_k127_807331_5 Lysine biosynthesis K05827 - 6.3.2.43 0.00000000000000000000003689 99.0
TLS2_k127_807331_6 Protein of unknown function DUF72 - - - 0.00000000000222 70.0
TLS2_k127_86847_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 1.955e-271 840.0
TLS2_k127_86847_1 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004946 595.0
TLS2_k127_86847_10 Nicotinamide-nucleotide adenylyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000612 276.0
TLS2_k127_86847_11 PFAM Iron dependent repressor, metal binding and dimerisation domain K03709 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003367 255.0
TLS2_k127_86847_12 Hexapeptide repeat of succinyl-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004206 246.0
TLS2_k127_86847_13 - - - - 0.0000000000000000000000000000000000000000000000000001029 192.0
TLS2_k127_86847_14 - - - - 0.0000000000000000000000000000000000000000000000000001157 191.0
TLS2_k127_86847_15 - - - - 0.00000000000000000000000000000000000000000000000005866 183.0
TLS2_k127_86847_16 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.00000000000000000000000000000000000000000000002218 171.0
TLS2_k127_86847_17 Lrp/AsnC ligand binding domain - - - 0.00000000000000000000000000000000000000003801 153.0
TLS2_k127_86847_18 Trm112p-like protein - - - 0.00000000000000000000000000000000006663 136.0
TLS2_k127_86847_19 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000105 109.0
TLS2_k127_86847_2 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 518.0
TLS2_k127_86847_22 Transcriptional regulator - - - 0.00005114 50.0
TLS2_k127_86847_3 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 513.0
TLS2_k127_86847_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 494.0
TLS2_k127_86847_5 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 483.0
TLS2_k127_86847_6 Oxidoreductase family, NAD-binding Rossmann fold K18855 - 1.1.1.374 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 458.0
TLS2_k127_86847_7 D-isomer specific 2-hydroxyacid dehydrogenase K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 439.0
TLS2_k127_86847_8 Protein of unknown function (DUF354) K09726 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 438.0
TLS2_k127_86847_9 Archaeal transcriptional regulator TrmB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 376.0
TLS2_k127_87919_0 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005449 444.0
TLS2_k127_87919_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003708 297.0
TLS2_k127_87919_2 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000000000008953 211.0
TLS2_k127_898974_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 493.0
TLS2_k127_898974_1 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 473.0
TLS2_k127_898974_2 Formyl transferase K01433 - 3.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 439.0
TLS2_k127_898974_3 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 306.0
TLS2_k127_898974_4 Histidine-specific methyltransferase, SAM-dependent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005587 285.0
TLS2_k127_898974_5 PFAM TCP-1 cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.0000000000000000000000000000000000000000000000606 169.0
TLS2_k127_898974_6 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00000000000000000000000000000000000000000002633 169.0
TLS2_k127_898974_7 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000000000000000000000000000000005733 138.0
TLS2_k127_898974_9 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000003788 63.0
TLS2_k127_899224_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 3.973e-315 972.0
TLS2_k127_899224_1 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 4.073e-315 975.0
TLS2_k127_899224_10 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 284.0
TLS2_k127_899224_11 PFAM Sodium calcium exchanger protein K07300 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000233 292.0
TLS2_k127_899224_12 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000008933 229.0
TLS2_k127_899224_13 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000000000000000000000000001481 213.0
TLS2_k127_899224_14 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.00000000000000000000000000000000000000000000000000000000000246 210.0
TLS2_k127_899224_15 COG0346 Lactoylglutathione lyase and related lyases K07032 - - 0.00000000000000000000000000000000000000000000000000000003233 201.0
TLS2_k127_899224_16 PFAM TCP-1 cpn60 chaperonin family K22447 - - 0.000000000000000000000000000000000000000000000001501 174.0
TLS2_k127_899224_17 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000000000006838 140.0
TLS2_k127_899224_18 Binds to the 23S rRNA K02896 - - 0.0000000000000000000000000000000001211 132.0
TLS2_k127_899224_19 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.000000000000000000000000000000001604 129.0
TLS2_k127_899224_2 Aconitase family (aconitate hydratase) K01681 - 4.2.1.3 1.002e-256 807.0
TLS2_k127_899224_20 zinc finger - - - 0.0000000000000002336 79.0
TLS2_k127_899224_22 PFAM response regulator receiver - - - 0.00000005936 60.0
TLS2_k127_899224_3 Belongs to the phosphohexose mutase family K15778 - 5.4.2.2,5.4.2.8 9.634e-230 717.0
TLS2_k127_899224_4 TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 - 2.6.1.16 3.231e-217 688.0
TLS2_k127_899224_5 Belongs to the PdxS SNZ family K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008636 551.0
TLS2_k127_899224_6 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008158 451.0
TLS2_k127_899224_7 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 447.0
TLS2_k127_899224_8 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 389.0
TLS2_k127_899224_9 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003778 324.0
TLS2_k127_91471_0 - - - - 0.00000000000000000000000006367 114.0
TLS2_k127_91674_0 GTPase of unknown function C-terminal K06942 - - 1.064e-233 726.0
TLS2_k127_934837_0 PFAM CBS domain K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 347.0
TLS2_k127_934837_2 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000003332 68.0
TLS2_k127_934837_3 - - - - 0.00002618 48.0
TLS2_k127_934932_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002211 258.0
TLS2_k127_934932_2 UPF0056 membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003928 243.0
TLS2_k127_934932_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000001184 143.0
TLS2_k127_934932_4 PFAM alpha beta hydrolase fold - - - 0.00000000000000000000000000000002357 130.0
TLS2_k127_934932_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.0000000000000000000000003598 110.0
TLS2_k127_934932_6 - - - - 0.000000000000002393 78.0
TLS2_k127_966409_0 ABC 3 transport family K09816 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 331.0
TLS2_k127_966409_1 PFAM ABC transporter K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 329.0
TLS2_k127_966409_2 Periplasmic solute binding protein K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 319.0
TLS2_k127_966409_3 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000001416 216.0
TLS2_k127_966409_4 Belongs to the Dps family K04047 - - 0.00000000000000000000000000000000000000000001859 167.0
TLS2_k127_966409_5 Ribbon-helix-helix protein, copG family K07722 - - 0.000000000000000000000000000000000000000000341 162.0
TLS2_k127_966409_6 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.00000000000000000000000000000000000008352 145.0
TLS2_k127_966409_7 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.00000000004526 63.0
TLS2_k127_966409_8 - - - - 0.000001054 56.0