Overview

ID MAG04001
Name TLS2_bin.35
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Nevskiales
Family Nevskiaceae
Genus Stagnimonas
Species
Assembly information
Completeness (%) 73.25
Contamination (%) 1.7
GC content (%) 68.0
N50 (bp) 5,487
Genome size (bp) 2,592,193

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2533

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_101526_0 Tetratricopeptide repeat - - - 1.785e-314 1007.0
TLS2_k127_101526_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 608.0
TLS2_k127_101526_2 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000201 284.0
TLS2_k127_101526_3 lytic transglycosylase K08307 - - 0.00000000000000000000000000000000000000000000000000000002045 212.0
TLS2_k127_101526_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000183 178.0
TLS2_k127_101526_5 Biopolymer transport protein ExbD/TolR - - - 0.000000000000000000000000000000000000000005219 160.0
TLS2_k127_101526_6 Biopolymer transport protein ExbD/TolR - - - 0.000000000000000000000000000000000000000008281 163.0
TLS2_k127_101526_7 - - - - 0.00000000000000000008395 95.0
TLS2_k127_101526_8 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000000001505 76.0
TLS2_k127_1017689_0 Carboxyl transferase domain - - - 5.038e-305 938.0
TLS2_k127_1017689_1 transcriptional regulator K22105 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007062 282.0
TLS2_k127_1017689_2 Oxidoreductase FAD-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001967 258.0
TLS2_k127_1018392_0 NADH ubiquinone oxidoreductase subunit K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 509.0
TLS2_k127_1018392_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 470.0
TLS2_k127_1018392_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 336.0
TLS2_k127_1018392_3 Belongs to the complex I subunit 6 family K00339 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000000000000000000000000000000008352 180.0
TLS2_k127_1018392_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000000000000000000000001172 157.0
TLS2_k127_1018392_5 NADH-quinone oxidoreductase K00336 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0048037,GO:0050136,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000001614 94.0
TLS2_k127_103810_0 Transporter K06189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009154 400.0
TLS2_k127_103810_1 Domain of unknown function (DUF4105) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003811 398.0
TLS2_k127_103810_2 Phosphate starvation-inducible protein PhoH K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 366.0
TLS2_k127_103810_3 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000000000000000000000000001184 183.0
TLS2_k127_1046320_0 Fungalysin metallopeptidase (M36) - - - 0.0 1062.0
TLS2_k127_1046320_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 375.0
TLS2_k127_1046320_2 Nucleoside-diphosphate-sugar epimerases - - - 0.000000000000000000000000000000000000000000000000000000000000000001853 233.0
TLS2_k127_1046320_3 protein possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000000000000000000000000005044 191.0
TLS2_k127_1046344_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 586.0
TLS2_k127_1046344_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 308.0
TLS2_k127_1046344_2 transcriptional - - - 0.00000000000000000000000000002581 121.0
TLS2_k127_1046344_3 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000000001672 116.0
TLS2_k127_1050763_0 Acetyl-CoA dehydrogenase C-terminal like - - - 8.972e-266 829.0
TLS2_k127_1050763_1 COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog - - - 4.033e-261 822.0
TLS2_k127_1050763_2 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000968 431.0
TLS2_k127_1050763_3 NADPH-dependent FMN reductase - - - 0.00000000000000000002077 95.0
TLS2_k127_1050763_4 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor K02275 - 1.9.3.1 0.00000000000000000005728 96.0
TLS2_k127_1050763_6 Antibiotic biosynthesis monooxygenase - - - 0.000005802 53.0
TLS2_k127_1053778_0 ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component K02004 - - 1.849e-295 929.0
TLS2_k127_1053778_1 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007918 293.0
TLS2_k127_1053778_2 COG2755 Lysophospholipase L1 and related esterases K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000003884 244.0
TLS2_k127_1053778_3 - - - - 0.00000000000000000000000000000000000000002813 162.0
TLS2_k127_1053778_4 Putative peptidoglycan binding domain - - - 0.0000000000000008836 79.0
TLS2_k127_1053778_5 - - - - 0.00000000000004371 83.0
TLS2_k127_1056388_0 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0006109,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009889,GO:0009987,GO:0010556,GO:0010675,GO:0010962,GO:0016051,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031326,GO:0031975,GO:0032881,GO:0032885,GO:0032950,GO:0032951,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0043255,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0050789,GO:0050794,GO:0051273,GO:0051274,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901576,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 502.0
TLS2_k127_1056388_1 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 406.0
TLS2_k127_1056388_2 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000002341 264.0
TLS2_k127_1056388_3 Phosphate-selective porin O and P K07221 - - 0.0000000000000000000000000000000000000000000000000000009399 209.0
TLS2_k127_1069020_0 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 480.0
TLS2_k127_1069020_1 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000806 283.0
TLS2_k127_1069020_2 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides - - - 0.0000000000000000000000000000000000000000000000000001836 194.0
TLS2_k127_1076056_0 MMPL family - - - 0.0 1209.0
TLS2_k127_1076056_1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - - 2.092e-216 676.0
TLS2_k127_1076056_2 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 424.0
TLS2_k127_1076056_3 protein related to plant photosystem II stability assembly factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000785 338.0
TLS2_k127_1076056_4 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002932 250.0
TLS2_k127_1076056_5 YjbR - - - 0.0000000000000000000000000000000008868 134.0
TLS2_k127_1076056_6 Protein of unknown function (DUF1302) - - - 0.0000000000000000000000000000001841 127.0
TLS2_k127_1085705_0 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 364.0
TLS2_k127_1085705_1 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003156 299.0
TLS2_k127_1085705_2 Belongs to the DnaA family. HdA subfamily K10763 - - 0.000000000000000000000000000000000000000000000000006486 203.0
TLS2_k127_11035_0 Belongs to the UPF0276 family K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 385.0
TLS2_k127_11035_1 Cupin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008835 276.0
TLS2_k127_11035_2 DoxX - - - 0.00000000000000000000000000000000000000000000000000000000000000000582 245.0
TLS2_k127_11035_3 Putative DNA-binding domain K09929 - - 0.000000000000000000000000000000000000000000000000000000000005308 214.0
TLS2_k127_11035_4 - - - - 0.00000000000000000001393 97.0
TLS2_k127_1130596_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 598.0
TLS2_k127_1130596_1 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000000000000002192 235.0
TLS2_k127_1130596_2 Aminotransferase class-V K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000001886 237.0
TLS2_k127_1130596_3 type IV pilus biogenesis stability protein PilW K02656 - - 0.000000000000000000000000000000000000000000000000000000000001563 218.0
TLS2_k127_1130596_4 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000000000000000000000003851 162.0
TLS2_k127_1140496_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 600.0
TLS2_k127_1140496_1 abc transporter atp-binding protein K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003247 393.0
TLS2_k127_1140496_2 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000000000000000000000000000007437 237.0
TLS2_k127_1140496_3 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000008879 219.0
TLS2_k127_1140496_4 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.00000000000000000000000000000000000000000000000000000000002304 209.0
TLS2_k127_1140496_5 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000001467 184.0
TLS2_k127_1140496_6 modulation protein K05808 - - 0.000000000000000000000000000000000001295 140.0
TLS2_k127_1140496_7 OstA-like protein - - - 0.00000000000000000000000001744 115.0
TLS2_k127_1140496_8 Lipopolysaccharide-assembly, LptC-related - - - 0.0000000000000000007696 93.0
TLS2_k127_1140496_9 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000008585 54.0
TLS2_k127_1175814_0 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 1.564e-298 922.0
TLS2_k127_1175814_1 Electron transfer flavoprotein K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 448.0
TLS2_k127_1175814_2 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007298 411.0
TLS2_k127_1175814_3 electron transfer flavoprotein beta subunit K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 399.0
TLS2_k127_1175814_4 chemotaxis protein K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 298.0
TLS2_k127_1175814_5 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006186 272.0
TLS2_k127_1175814_6 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000001659 268.0
TLS2_k127_1175814_7 Helix-turn-helix domain - - - 0.0000000000000000000000004671 108.0
TLS2_k127_1176738_0 CoA-transferase family III - - - 0.0 1360.0
TLS2_k127_1176738_1 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001788 265.0
TLS2_k127_1189692_0 Protein of unknown function (DUF1800) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 403.0
TLS2_k127_1189692_1 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004014 325.0
TLS2_k127_1189692_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000000000001428 191.0
TLS2_k127_1206736_0 Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 380.0
TLS2_k127_1206736_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 371.0
TLS2_k127_1206736_2 transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 336.0
TLS2_k127_1206736_3 L,D-transpeptidase catalytic domain - - - 0.00000000001837 71.0
TLS2_k127_1211893_0 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 375.0
TLS2_k127_1211893_1 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 324.0
TLS2_k127_1211893_2 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004135 242.0
TLS2_k127_1220467_0 2-Nitropropane dioxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 481.0
TLS2_k127_1220467_1 Domain of unknown function (DUF4169) - - - 0.000000000001869 69.0
TLS2_k127_1220467_2 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0001746 44.0
TLS2_k127_1222610_0 TrkA-N domain - - - 9.156e-225 704.0
TLS2_k127_1222610_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 9.512e-220 692.0
TLS2_k127_1222610_2 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 441.0
TLS2_k127_1222610_3 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 325.0
TLS2_k127_1222610_4 Protein of unknown function (DUF971) - - - 0.0000000000000000000000000000000000000000000000000006571 188.0
TLS2_k127_1242190_0 secretion system protein K02453 - - 5.744e-232 734.0
TLS2_k127_1242190_1 Type II secretion system protein C K02452 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001888 246.0
TLS2_k127_1244322_0 Superfamily I DNA and RNA helicases and helicase subunits - - - 5.416e-311 976.0
TLS2_k127_1256674_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 7.471e-194 608.0
TLS2_k127_1256674_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 580.0
TLS2_k127_1256674_2 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 466.0
TLS2_k127_1280659_0 Alkyl sulfatase dimerisation - - - 2.589e-195 618.0
TLS2_k127_1280659_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000656 249.0
TLS2_k127_1293894_0 membrane - - - 2.419e-246 781.0
TLS2_k127_1293894_1 TIGRFAM type IV pilus modification protein PilV K02671 - - 0.000000000000000000000000000000000108 141.0
TLS2_k127_1293894_2 Belongs to the UPF0337 (CsbD) family - - - 0.000000000000000001257 87.0
TLS2_k127_1293894_3 - - - - 0.0000005876 59.0
TLS2_k127_1296683_0 dehydrogenase K13979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005848 539.0
TLS2_k127_1296683_1 Predicted membrane protein (DUF2238) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000701 374.0
TLS2_k127_1296683_2 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001445 279.0
TLS2_k127_1296683_3 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001457 233.0
TLS2_k127_1296683_4 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000008467 94.0
TLS2_k127_1296683_5 - - - - 0.00000000000000001865 91.0
TLS2_k127_1309856_0 GMC oxidoreductase K00108 - 1.1.99.1 3.702e-218 695.0
TLS2_k127_1309856_1 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006942 546.0
TLS2_k127_1309856_2 Phospholipid methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006805 398.0
TLS2_k127_1309856_3 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000094 310.0
TLS2_k127_1309856_4 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 311.0
TLS2_k127_1309856_5 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000009302 188.0
TLS2_k127_1309856_6 - - - - 0.00000000000000000000000000000000001786 141.0
TLS2_k127_1320262_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) - - - 1.509e-278 866.0
TLS2_k127_1320262_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008622 372.0
TLS2_k127_1320262_2 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000001322 184.0
TLS2_k127_1337432_0 Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate K06447 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.71 1.086e-221 696.0
TLS2_k127_1337432_1 Arginine N-succinyltransferase beta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 477.0
TLS2_k127_1342841_0 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 401.0
TLS2_k127_1342841_1 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006311 291.0
TLS2_k127_1342841_2 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000000000000000006826 221.0
TLS2_k127_1342841_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000006103 93.0
TLS2_k127_137606_0 COG0451 Nucleoside-diphosphate-sugar epimerases K08679,K17947 - 5.1.3.25,5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 462.0
TLS2_k127_137606_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 289.0
TLS2_k127_137606_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000004148 136.0
TLS2_k127_139646_0 GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006798 316.0
TLS2_k127_139913_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 5.019e-253 784.0
TLS2_k127_139913_1 Alkaline phosphatase K01113 - 3.1.3.1 4.451e-214 682.0
TLS2_k127_139913_2 Protein of unknown function (DUF808) K09781 - - 0.000000000000000000000000000000000000000000000000000000151 198.0
TLS2_k127_139913_3 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000000000004354 145.0
TLS2_k127_139913_4 Belongs to the UPF0307 family K09889 - - 0.000000000000000000000000000000000004391 145.0
TLS2_k127_1402137_0 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 418.0
TLS2_k127_1402137_1 N-acyl-L-amino acid amidohydrolase K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001747 261.0
TLS2_k127_1402137_2 Domain of unknown function (DU1801) - - - 0.000000000000000000000002274 107.0
TLS2_k127_1407726_0 Fatty acid desaturase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 445.0
TLS2_k127_1407726_1 ParB-like nuclease domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004651 362.0
TLS2_k127_1407726_2 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004145 310.0
TLS2_k127_1407726_3 MltA-interacting protein MipA - - - 0.00000000000000000000000000000000000000003303 163.0
TLS2_k127_1407726_4 - - - - 0.000000000000000004177 89.0
TLS2_k127_1429817_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 432.0
TLS2_k127_1429817_1 abc transporter atp-binding protein K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007249 353.0
TLS2_k127_1429817_2 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 365.0
TLS2_k127_1429817_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 344.0
TLS2_k127_1435891_0 COG2366 Protein related to penicillin acylase K07116 - 3.5.1.97 2.669e-259 811.0
TLS2_k127_1435891_1 COG0183 Acetyl-CoA acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 391.0
TLS2_k127_1435891_2 Rubredoxin-like zinc ribbon domain (DUF35_N) - - - 0.00000000000000000000000000000000000000000000000000000000000000002256 226.0
TLS2_k127_1447674_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18303 - - 0.0 1447.0
TLS2_k127_1447674_1 Belongs to the class I fructose-bisphosphate aldolase family K01623 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008761 538.0
TLS2_k127_1447674_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 334.0
TLS2_k127_1447674_3 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000433 245.0
TLS2_k127_1447674_4 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000001425 169.0
TLS2_k127_1447674_5 Transcriptional regulator - - - 0.00000000000000000005727 93.0
TLS2_k127_1472213_0 - - - - 9.811e-217 687.0
TLS2_k127_1475008_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 602.0
TLS2_k127_1475008_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000003581 173.0
TLS2_k127_1475008_2 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000007869 141.0
TLS2_k127_1477399_0 COG3459 Cellobiose phosphorylase - - - 0.0 1325.0
TLS2_k127_1477399_1 F5/8 type C domain - - - 5.502e-284 895.0
TLS2_k127_1489143_0 Molecular chaperone. Has ATPase activity K04079 - - 1.291e-309 984.0
TLS2_k127_1489143_1 Ammonium transporter - - - 8.905e-208 653.0
TLS2_k127_1489143_2 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001579 254.0
TLS2_k127_1489143_3 YceI-like domain - - - 0.000000000000000000000000000000000006675 139.0
TLS2_k127_1489143_4 - - - - 0.0000000001896 66.0
TLS2_k127_1507093_0 Putative amidoligase enzyme (DUF2126) - - - 0.0 1615.0
TLS2_k127_1507093_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 1.77e-283 882.0
TLS2_k127_1507093_10 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000003063 120.0
TLS2_k127_1507093_11 relative of glutathione S-transferase, MAPEG superfamily K07136 - - 0.00000000000000000000000000000714 131.0
TLS2_k127_1507093_12 Cytochrome c - - - 0.000000000000000000000000017 116.0
TLS2_k127_1507093_13 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000001162 91.0
TLS2_k127_1507093_14 Polynucleotide kinase 3 phosphatase - - - 0.00000234 50.0
TLS2_k127_1507093_2 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 9.5e-267 841.0
TLS2_k127_1507093_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 1.259e-225 725.0
TLS2_k127_1507093_4 Belongs to the GppA Ppx family K01524 - 3.6.1.11,3.6.1.40 1.936e-213 685.0
TLS2_k127_1507093_5 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 550.0
TLS2_k127_1507093_6 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 497.0
TLS2_k127_1507093_7 Glutamyl-tRNA amidotransferase K09117 - - 0.0000000000000000000000000000000000000000000000000000000000000002154 224.0
TLS2_k127_1507093_8 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000001674 168.0
TLS2_k127_1507093_9 cytochrome - - - 0.0000000000000000000000000000000000000000009675 160.0
TLS2_k127_1507820_0 cytochrome C peroxidase - - - 0.0 1102.0
TLS2_k127_1507820_1 PhoD-like phosphatase, N-terminal domain K01113 - 3.1.3.1 0.0000000000000000000000000000000000000866 146.0
TLS2_k127_1532005_0 Flavin-binding monooxygenase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 443.0
TLS2_k127_1532005_1 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009134 401.0
TLS2_k127_1532005_2 Serine aminopeptidase, S33 K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 324.0
TLS2_k127_1532005_3 Cysteine-rich CWC - - - 0.0000000000000000000001362 101.0
TLS2_k127_1532253_0 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - - 2.564e-224 703.0
TLS2_k127_1532253_1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000000000002913 268.0
TLS2_k127_1532253_2 - - - - 0.0000000000000000000000000000000000211 140.0
TLS2_k127_1532253_3 Enoyl-(Acyl carrier protein) reductase K07124 - - 0.00000000000000008761 80.0
TLS2_k127_1537642_0 Fatty acid synthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 428.0
TLS2_k127_1537642_1 Major facilitator superfamily K07552 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 370.0
TLS2_k127_1537642_2 Maf-like protein K06287 - - 0.00000000000000000000000000001717 129.0
TLS2_k127_1537642_3 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000002126 129.0
TLS2_k127_1537642_4 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000000000107 108.0
TLS2_k127_1544592_0 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002139 255.0
TLS2_k127_1544592_1 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000003127 233.0
TLS2_k127_1544592_2 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000001064 190.0
TLS2_k127_1544592_3 SnoaL-like domain - - - 0.00000000000000000000000000000000000000003227 162.0
TLS2_k127_15635_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 1.508e-308 953.0
TLS2_k127_15635_1 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 532.0
TLS2_k127_15635_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 416.0
TLS2_k127_15635_3 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 304.0
TLS2_k127_15635_4 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.00000000000000000000000000000000000000000000006676 169.0
TLS2_k127_15635_5 Colicin v production K03558 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - 0.00000000000000000000000000000000000005544 149.0
TLS2_k127_15635_6 Lipopolysaccharide assembly protein A domain - - - 0.0000000000000000000002755 99.0
TLS2_k127_15635_7 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000001081 57.0
TLS2_k127_1564302_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.933e-215 679.0
TLS2_k127_1564302_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005623 591.0
TLS2_k127_1564302_2 Protein of unknown function (DUF1501) - - - 0.0000000000000000000000000000000000000000004276 160.0
TLS2_k127_1564302_3 - - - - 0.000000000000000000000000000001239 127.0
TLS2_k127_1631958_0 Sterol-sensing domain of SREBP cleavage-activation - - - 9.355e-284 897.0
TLS2_k127_1631958_1 Outer membrane lipoprotein-sorting protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 290.0
TLS2_k127_1631958_2 Ketopantoate reductase PanE/ApbA C terminal - - - 0.00000001691 59.0
TLS2_k127_1649605_0 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004844 527.0
TLS2_k127_1649605_1 TonB-dependent receptor K02014 - - 0.000000000003149 67.0
TLS2_k127_1656119_0 chemotaxis protein - - - 3.936e-253 810.0
TLS2_k127_1656119_1 chemotaxis protein K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 593.0
TLS2_k127_1656119_2 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006895 337.0
TLS2_k127_1656119_3 chemotaxis signal transduction protein K03408 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000491 258.0
TLS2_k127_1661007_0 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003842 359.0
TLS2_k127_1661007_1 Multidrug efflux pump K03327 GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0022857,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085 - 0.00000000000000000000000000000000000000000004296 163.0
TLS2_k127_1661007_2 Trypsin-like peptidase domain K01337 - 3.4.21.50 0.00000000000000000000001022 116.0
TLS2_k127_1678038_0 AMP-binding enzyme - - - 1.936e-228 719.0
TLS2_k127_1678038_1 Strictosidine synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 361.0
TLS2_k127_1678038_2 Protein of unknown function (DUF2855) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003487 320.0
TLS2_k127_1678038_3 transferase activity, transferring acyl groups K15520 - 2.3.1.189 0.00000000000000000000000000000000001466 144.0
TLS2_k127_170095_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - 7.904e-216 682.0
TLS2_k127_170095_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004432 551.0
TLS2_k127_170095_2 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 329.0
TLS2_k127_1712911_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 1.1e-212 674.0
TLS2_k127_1712911_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 534.0
TLS2_k127_1712911_2 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 335.0
TLS2_k127_1712911_3 Cyclic nucleotide-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006599 278.0
TLS2_k127_1712911_4 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000894 222.0
TLS2_k127_1712911_5 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000000000000003904 183.0
TLS2_k127_1712911_6 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000001217 101.0
TLS2_k127_1728334_0 Glutamate-1-semialdehyde aminotransferase K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 599.0
TLS2_k127_1728334_1 LssY C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006845 538.0
TLS2_k127_1728334_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 494.0
TLS2_k127_1728334_3 RNA polymerase sigma factor RpoH K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003705 383.0
TLS2_k127_1728334_4 cell division ATP-binding protein FtsE K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 353.0
TLS2_k127_1728334_5 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 339.0
TLS2_k127_1728334_6 Copper chaperone PCu(A)C K09796 - - 0.000000000000000000000000000305 122.0
TLS2_k127_1728334_7 biopolymer transport protein K03559,K03560 - - 0.0000000000000000000001286 103.0
TLS2_k127_1740699_0 M61 glycyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 477.0
TLS2_k127_1740699_1 AMP-dependent synthetase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000003728 240.0
TLS2_k127_1756256_0 Ndr family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 332.0
TLS2_k127_1756256_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001472 271.0
TLS2_k127_1756256_2 - - - - 0.000000000000000000000000000000000000008884 149.0
TLS2_k127_1756256_3 Protein of unknown function (DUF2892) - - - 0.000000000000000000002528 94.0
TLS2_k127_1762308_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002843 608.0
TLS2_k127_1762308_1 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.298 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 302.0
TLS2_k127_1762308_2 Multidrug DMT transporter permease - - - 0.0000000000000000000000000000000000000000004205 166.0
TLS2_k127_1762308_3 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000000000000000005119 115.0
TLS2_k127_1762308_4 - - - - 0.00000007233 58.0
TLS2_k127_1781455_0 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family - - - 0.0 1036.0
TLS2_k127_1781455_1 TIGRFAM nitrate ABC transporter, ATPase subunits C and D K15578 - - 0.000000000000000000000000000009669 119.0
TLS2_k127_1789068_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - - 3.691e-305 949.0
TLS2_k127_1789068_1 Multidrug efflux pump K03327 GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0022857,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085 - 0.0000000000000000000000000002137 118.0
TLS2_k127_1789068_2 PDZ domain - - - 0.0000003344 55.0
TLS2_k127_1789351_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 487.0
TLS2_k127_1789351_1 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007378 407.0
TLS2_k127_1789351_2 - - - - 0.0000000000000000000000000000000000000000000000000000004477 203.0
TLS2_k127_1789351_3 DUF218 domain - - - 0.000000000000000000000000000000000000003105 154.0
TLS2_k127_1789351_4 Dimerisation domain of Zinc Transporter - - - 0.00000000000000000001072 94.0
TLS2_k127_1794685_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 - 1.112e-248 779.0
TLS2_k127_1794685_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004642 558.0
TLS2_k127_1794685_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 511.0
TLS2_k127_1794685_3 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000002292 204.0
TLS2_k127_1794685_4 Histidine triad (HIT) protein K02503 - - 0.0000000000000000000000000000000000000001844 172.0
TLS2_k127_1794685_6 Peptidase family M23 - - - 0.0000000001177 62.0
TLS2_k127_1797698_0 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 4.941e-227 707.0
TLS2_k127_1797698_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009079 505.0
TLS2_k127_1797698_10 Protein of unknown function (DUF3365) - - - 0.0000000000000000000000000000003126 139.0
TLS2_k127_1797698_11 PFAM SMP-30 Gluconolaconase K01179,K01181,K01218,K02014 - 3.2.1.4,3.2.1.78,3.2.1.8 0.000000000007691 73.0
TLS2_k127_1797698_2 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008329 414.0
TLS2_k127_1797698_3 Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 346.0
TLS2_k127_1797698_5 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006521 312.0
TLS2_k127_1797698_6 Protein of unknown function (DUF938) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 289.0
TLS2_k127_1797698_7 N-formylglutamate amidohydrolase K01458,K01479 - 3.5.1.68,3.5.3.8 0.0000000000000000000000000000000000000000000000000000000000000000004889 231.0
TLS2_k127_1797698_8 MAPEG family - - - 0.00000000000000000000000000000000000000002678 156.0
TLS2_k127_1797698_9 Belongs to the UPF0225 family K09858 - - 0.000000000000000000000000000000000000001615 151.0
TLS2_k127_1842650_0 D-arabinono-1,4-lactone oxidase - - - 1.769e-251 781.0
TLS2_k127_1842650_1 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000002721 211.0
TLS2_k127_1842650_2 helix_turn_helix, cAMP Regulatory protein - - - 0.000000000000000000000000000000000000000002912 156.0
TLS2_k127_1842650_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000003576 158.0
TLS2_k127_1852796_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 2.199e-288 910.0
TLS2_k127_1852796_1 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 331.0
TLS2_k127_1852796_2 ErfK ybiS ycfS ynhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001384 265.0
TLS2_k127_1852796_3 Host attachment protein - - - 0.00000000000000000000000000007953 121.0
TLS2_k127_1876970_0 signal peptide peptidase K04773 - - 4.741e-217 691.0
TLS2_k127_1876970_1 Alkyl hydroperoxide reductase K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005698 321.0
TLS2_k127_1876970_2 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000001226 229.0
TLS2_k127_1876970_3 Alkyl hydroperoxide reductase K03386 - 1.11.1.15 0.00000000000000000000001242 102.0
TLS2_k127_1894583_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 3.974e-233 730.0
TLS2_k127_1894583_1 abc transporter atp-binding protein K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 581.0
TLS2_k127_1894583_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009928 550.0
TLS2_k127_1894583_3 OmpA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005817 306.0
TLS2_k127_1894583_4 Transporter Component K07112 - - 0.0000000000000000000000000000002062 126.0
TLS2_k127_1899751_0 PFAM Cytochrome c, class I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 445.0
TLS2_k127_1899751_1 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 310.0
TLS2_k127_1899751_2 Bacterial Ig-like domain (group 1) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005222 324.0
TLS2_k127_1899751_3 Cytochrome - - - 0.0000000000000000000000000000000000000000000000000000000000008711 217.0
TLS2_k127_1899751_4 PFAM metallophosphoesterase K07313 - 3.1.3.16 0.00000000000000000000000000000000004053 145.0
TLS2_k127_1903767_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 370.0
TLS2_k127_1903767_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003332 362.0
TLS2_k127_1903767_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000446 257.0
TLS2_k127_1903767_3 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000000000000000000003865 142.0
TLS2_k127_1905514_0 Flavin-binding monooxygenase-like - - - 1.253e-223 703.0
TLS2_k127_1905514_1 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 394.0
TLS2_k127_1905514_2 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 368.0
TLS2_k127_1905514_3 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000006919 128.0
TLS2_k127_1905514_4 Alpha/beta hydrolase family - - - 0.0000000000002782 72.0
TLS2_k127_1914732_0 COG1199 Rad3-related DNA helicases K10844 - 3.6.4.12 2.257e-242 765.0
TLS2_k127_1914732_1 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000517 514.0
TLS2_k127_1914732_10 protein homooligomerization - - - 0.00004061 51.0
TLS2_k127_1914732_2 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 475.0
TLS2_k127_1914732_3 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000992 452.0
TLS2_k127_1914732_4 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 426.0
TLS2_k127_1914732_5 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 312.0
TLS2_k127_1914732_6 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000005866 239.0
TLS2_k127_1914732_7 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000000000000007893 207.0
TLS2_k127_1914732_8 Ion channel - - - 0.000000000000000000000000000000000000000000000000000003525 194.0
TLS2_k127_1914732_9 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.0000000000000000115 95.0
TLS2_k127_1936043_0 The M ring may be actively involved in energy transduction K02409 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004948 380.0
TLS2_k127_1936043_1 Flagellar hook-basal body complex protein FliE K02408 - - 0.000000000000000000001347 101.0
TLS2_k127_1938509_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 6.157e-226 704.0
TLS2_k127_1938509_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 308.0
TLS2_k127_1938509_2 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000000001648 147.0
TLS2_k127_1938509_3 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000009831 127.0
TLS2_k127_1938509_4 protein acetylation K02348 - - 0.0000000000000000000007499 103.0
TLS2_k127_194452_0 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 0.0 1024.0
TLS2_k127_194452_1 Regulatory protein, FmdB family - - - 0.0000000000000000000000000001012 119.0
TLS2_k127_194452_2 domain, Protein - - - 0.0000000000000001638 89.0
TLS2_k127_1968267_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1395.0
TLS2_k127_1968267_1 Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA - - - 8.774e-221 689.0
TLS2_k127_1968267_2 outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 490.0
TLS2_k127_1968267_3 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 459.0
TLS2_k127_1968267_4 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 445.0
TLS2_k127_1968267_5 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 317.0
TLS2_k127_1968267_6 carboxymethylenebutenolidase activity K01061,K22249 - 3.1.1.45,3.1.1.76 0.000000000000000000000000000000000000000000000000000000000000000003732 236.0
TLS2_k127_1968267_7 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 0.00000000000003154 72.0
TLS2_k127_1968267_8 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 0.0004591 45.0
TLS2_k127_1969164_0 Domain of unknown function (DUF3336) - - - 7.92e-225 707.0
TLS2_k127_1969164_1 PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003256 328.0
TLS2_k127_1969164_2 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 286.0
TLS2_k127_1969164_3 membrane - - - 0.0000000000000000000000000000000000000000000000000000000009255 212.0
TLS2_k127_1969164_4 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.0000000000000000000000009242 112.0
TLS2_k127_1989435_0 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009112 603.0
TLS2_k127_1989435_1 Protein of unknown function (DUF1302) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 588.0
TLS2_k127_1989435_2 Protein of unknown function (DUF1329) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008117 502.0
TLS2_k127_1989435_3 Belongs to the ompA family K03286 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 294.0
TLS2_k127_1989435_4 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000001496 241.0
TLS2_k127_1989435_5 Prolyl oligopeptidase - - - 0.0000000000000000000000000000001644 126.0
TLS2_k127_1989435_6 diguanylate cyclase - - - 0.0000001994 54.0
TLS2_k127_2014141_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 565.0
TLS2_k127_2014141_1 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006916 543.0
TLS2_k127_2014141_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001583 278.0
TLS2_k127_2014141_3 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.0000000000000001327 85.0
TLS2_k127_2017049_0 Right handed beta helix region - - - 1.619e-254 795.0
TLS2_k127_2017049_1 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 436.0
TLS2_k127_2017049_2 Protein of unknown function (DUF1318) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000038 252.0
TLS2_k127_2017049_3 Ferrous iron transport protein B C terminus K04759 - - 0.00000000000000000000000000000000003118 136.0
TLS2_k127_2019744_0 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 601.0
TLS2_k127_2019744_1 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 601.0
TLS2_k127_2019744_2 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K09699 - 2.3.1.168 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006553 482.0
TLS2_k127_2019744_3 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004652 357.0
TLS2_k127_2019744_4 helix_turn_helix ASNC type - - - 0.00000000000000000000000000000000000000000000000000000000000001309 224.0
TLS2_k127_2019744_5 SWI complex, BAF60b domains - - - 0.00000000000000000000000000000000000000000000001021 174.0
TLS2_k127_2019744_6 Protein of unknown function (DUF2726) - - - 0.000000188 58.0
TLS2_k127_2022802_0 Cellulose synthase operon protein C C-terminus (BCSC_C) K20543 - - 3.971e-315 1002.0
TLS2_k127_2022802_1 - - - - 0.000000000000000000933 94.0
TLS2_k127_2035757_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 415.0
TLS2_k127_2035757_1 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005271 369.0
TLS2_k127_2035757_2 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 333.0
TLS2_k127_2035757_3 MotA TolQ ExbB proton channel K03561 - - 0.00000000000000000000000000000000000000000000000007122 186.0
TLS2_k127_2035757_4 Transcriptional regulator - - - 0.000000000000000000000000000000000004221 139.0
TLS2_k127_2035757_5 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.000000004349 67.0
TLS2_k127_2035757_6 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.00000005275 62.0
TLS2_k127_2035757_7 domain, Protein - - - 0.0001857 51.0
TLS2_k127_204015_0 Flavin-binding monooxygenase-like - - - 8.152e-234 732.0
TLS2_k127_204015_1 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 497.0
TLS2_k127_204015_2 ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 406.0
TLS2_k127_204015_3 Steryl acetyl hydrolase K14731 - 3.1.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000001428 273.0
TLS2_k127_204015_4 - - - - 0.000000000000000000000000000000000000000000000000000000000001446 214.0
TLS2_k127_204015_5 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000004131 212.0
TLS2_k127_204015_6 Protein of unknown function (DUF2798) - - - 0.0000000000000000000000001056 109.0
TLS2_k127_2051467_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1226.0
TLS2_k127_2051467_1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle K01638 - 2.3.3.9 8.632e-280 880.0
TLS2_k127_2051467_10 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000001115 125.0
TLS2_k127_2051467_11 - - - - 0.00000000000000000001113 101.0
TLS2_k127_2051467_2 Catalyzes the reversible formation of glyoxylate and succinate from isocitrate K01637 - 4.1.3.1 4.272e-271 837.0
TLS2_k127_2051467_3 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 427.0
TLS2_k127_2051467_4 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008489 328.0
TLS2_k127_2051467_5 glycoprotease K14742 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001847 251.0
TLS2_k127_2051467_6 SBF-like CPA transporter family (DUF4137) K03453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005254 249.0
TLS2_k127_2051467_7 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002951 258.0
TLS2_k127_2051467_8 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.000000000000000000000000000000000000000000000000000002908 196.0
TLS2_k127_2051467_9 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000004139 183.0
TLS2_k127_2066289_0 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005681 390.0
TLS2_k127_2066289_1 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 360.0
TLS2_k127_2066289_2 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000005088 226.0
TLS2_k127_2066289_3 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000000000000000000000000000000001682 223.0
TLS2_k127_2066289_4 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000009429 214.0
TLS2_k127_2066289_5 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000001038 156.0
TLS2_k127_2066289_6 Disulphide bond corrector protein DsbC - - - 0.00000000000000000000000000002185 123.0
TLS2_k127_2066289_7 protein involved in tolerance to divalent cations K03926 - - 0.00000000000000000000000000007188 119.0
TLS2_k127_2088011_0 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005776 322.0
TLS2_k127_2088011_1 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000000001448 250.0
TLS2_k127_2088011_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000006085 225.0
TLS2_k127_2088011_5 - - - - 0.0000000001102 65.0
TLS2_k127_2088011_6 - - - - 0.000000002111 65.0
TLS2_k127_2091499_0 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 393.0
TLS2_k127_2091499_1 PFAM ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000000000000000000000000000001964 218.0
TLS2_k127_2091499_2 Alginate lyase - - - 0.000000000000000000000000000000000000000000000001366 183.0
TLS2_k127_2091499_3 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000000000000001576 166.0
TLS2_k127_2091499_4 FecR protein - - - 0.00009669 54.0
TLS2_k127_2106988_0 cytochrome C peroxidase - - - 7.661e-248 789.0
TLS2_k127_2106988_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 4.798e-211 670.0
TLS2_k127_2106988_2 Flavin-binding monooxygenase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 615.0
TLS2_k127_2106988_3 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 326.0
TLS2_k127_2106988_4 Protein of unknown function (DUF3570) - - - 0.000007611 51.0
TLS2_k127_2109415_0 Imidazolone-5-propionate hydrolase K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008131 569.0
TLS2_k127_2109415_1 deiminase K05603 - 3.5.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 502.0
TLS2_k127_2109415_2 N-formylglutamate amidohydrolase K01458,K01479 - 3.5.1.68,3.5.3.8 0.000000000000000000000000001352 117.0
TLS2_k127_211368_0 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 512.0
TLS2_k127_211368_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005797 389.0
TLS2_k127_2149759_0 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009602 522.0
TLS2_k127_2152968_0 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 575.0
TLS2_k127_2152968_1 Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 435.0
TLS2_k127_2152968_2 haemagglutination activity domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005038 385.0
TLS2_k127_2152968_3 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000000000000000005394 205.0
TLS2_k127_2170307_0 Polyketide synthase dehydratase - - - 0.0 1237.0
TLS2_k127_2170307_1 Polyketide synthase dehydratase - - - 3.739e-293 918.0
TLS2_k127_2177163_0 Polyketide synthase dehydratase - - - 3.769e-220 692.0
TLS2_k127_2177163_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 600.0
TLS2_k127_2177163_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 569.0
TLS2_k127_2177163_3 UDP-glucoronosyl and UDP-glucosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 566.0
TLS2_k127_2177163_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 450.0
TLS2_k127_2177163_5 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 406.0
TLS2_k127_2177163_6 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 305.0
TLS2_k127_2177163_7 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000002039 127.0
TLS2_k127_2177163_8 MacB-like periplasmic core domain - - - 0.0001454 46.0
TLS2_k127_2177739_0 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 8.734e-222 709.0
TLS2_k127_2180221_0 DJ-1/PfpI family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 441.0
TLS2_k127_2180221_1 ABC-type uncharacterized transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005956 443.0
TLS2_k127_2180221_2 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008819 340.0
TLS2_k127_2180221_3 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 288.0
TLS2_k127_2180221_4 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001248 276.0
TLS2_k127_2180221_5 Domain of unknown function (DUF4340) - - - 0.0000000000000000000000000000000000000000000000000000000000000000205 235.0
TLS2_k127_2180221_6 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000154 214.0
TLS2_k127_2184310_0 Belongs to the WrbA family K03809 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004376 295.0
TLS2_k127_2184310_1 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006437 269.0
TLS2_k127_2184310_2 Predicted membrane protein (DUF2069) - - - 0.00000000007359 72.0
TLS2_k127_2196766_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 435.0
TLS2_k127_2196766_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 409.0
TLS2_k127_2196766_2 Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006602 312.0
TLS2_k127_2238975_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 5.627e-308 955.0
TLS2_k127_2238975_1 acetyl-coa hydrolase - - - 1.191e-278 874.0
TLS2_k127_2238975_2 acid) synthase K03821 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005387 472.0
TLS2_k127_2238975_3 Acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 349.0
TLS2_k127_2241324_0 TonB-dependent Receptor Plug Domain K02014 - - 0.0 1024.0
TLS2_k127_2241324_1 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.000000776 55.0
TLS2_k127_2260118_0 ATP-binding protein K06915 - - 1.703e-213 669.0
TLS2_k127_2260118_1 - - - - 0.0000000000000000000000000000000000000000000000002129 184.0
TLS2_k127_2275686_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0 1031.0
TLS2_k127_2275686_1 Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate K01955 GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 0.0 1011.0
TLS2_k127_2275686_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000991 584.0
TLS2_k127_2275686_3 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 349.0
TLS2_k127_2275686_4 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 316.0
TLS2_k127_2275686_5 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 315.0
TLS2_k127_2275686_6 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008193 248.0
TLS2_k127_2275686_7 Preprotein translocase subunit SecG K03075 - - 0.0000000000000000000000000000001323 129.0
TLS2_k127_2279054_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1056.0
TLS2_k127_2279054_1 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 538.0
TLS2_k127_2279054_2 MucB/RseB C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000008927 191.0
TLS2_k127_2279054_3 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000001105 156.0
TLS2_k127_2281602_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 434.0
TLS2_k127_2281602_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 385.0
TLS2_k127_2281602_2 COG0500 SAM-dependent methyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007622 304.0
TLS2_k127_2281602_3 Belongs to the short-chain dehydrogenases reductases (SDR) family K05886,K16066 - 1.1.1.276,1.1.1.381 0.0000000000000000000000000000000000000001017 151.0
TLS2_k127_2289379_0 - - - - 3.161e-275 872.0
TLS2_k127_2289379_1 Smr domain - - - 0.000000000000000000000000000000000000000000000000000000000004124 214.0
TLS2_k127_2289379_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.1.3.5 0.00000000000001114 75.0
TLS2_k127_2289379_3 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.00000000425 69.0
TLS2_k127_2289948_0 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004483 509.0
TLS2_k127_2289948_1 Plays a role in the flagellum-specific transport system K02419 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 303.0
TLS2_k127_2289948_2 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02417 - - 0.0000000000000000000000000000000000000000000392 163.0
TLS2_k127_2289948_3 Bacterial export proteins, family 3 K02420 - - 0.0000000000000000000000000000000008248 134.0
TLS2_k127_2289948_4 Flagellar biosynthesis protein, FliO - - - 0.00000000000006827 82.0
TLS2_k127_229908_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004431 276.0
TLS2_k127_229908_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000001354 124.0
TLS2_k127_229908_2 copG family - - - 0.0000000000000000003021 89.0
TLS2_k127_2321837_0 Prolyl oligopeptidase - - - 1.625e-222 706.0
TLS2_k127_2329892_0 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 455.0
TLS2_k127_2329892_1 Arginine N-succinyltransferase beta subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004568 380.0
TLS2_k127_2329892_2 Putative tRNA binding domain - - - 0.000000000000000000000000000000000163 149.0
TLS2_k127_2329892_3 Protein of unknown function (DUF3298) - - - 0.0000000000001027 81.0
TLS2_k127_2338170_0 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 497.0
TLS2_k127_2338170_1 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 332.0
TLS2_k127_2338170_2 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.0000000000000000000000000000000000000000000000000006138 191.0
TLS2_k127_2352789_0 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008669 280.0
TLS2_k127_2352789_1 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009993 257.0
TLS2_k127_2352789_2 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000008515 152.0
TLS2_k127_2352789_3 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000004925 139.0
TLS2_k127_2361834_0 Fis family transcriptional regulator K10941 - - 4.198e-195 619.0
TLS2_k127_2361834_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 424.0
TLS2_k127_2361834_2 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001539 242.0
TLS2_k127_2361834_3 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000003597 206.0
TLS2_k127_2361834_4 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000001687 173.0
TLS2_k127_2361834_5 Atypical PilZ domain, cyclic di-GMP receptor - - - 0.0000000000000000000000006731 111.0
TLS2_k127_2361834_6 flagellar protein FliS K02422 - - 0.000000000926 60.0
TLS2_k127_2361834_7 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.000000007628 65.0
TLS2_k127_2383872_0 Transcriptional regulator - - - 1.842e-219 689.0
TLS2_k127_2383872_1 peptidase, s15 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 478.0
TLS2_k127_2383872_2 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 375.0
TLS2_k127_2383872_3 Nitroreductase family - - - 0.0000000000000000000000000000000000000000002756 164.0
TLS2_k127_2383872_4 - - - - 0.000000000000000000002087 97.0
TLS2_k127_2383872_5 Protein of unknown function (DUF2970) - - - 0.0000000000000231 80.0
TLS2_k127_2385686_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 4.516e-245 763.0
TLS2_k127_2385686_1 NADP transhydrogenase K00324 - 1.6.1.2 4.189e-199 624.0
TLS2_k127_2385686_2 Fatty acid desaturase - - - 1.433e-194 612.0
TLS2_k127_2385686_3 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000001576 174.0
TLS2_k127_2385686_4 Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions K09913 - 2.4.2.1,2.4.2.2 0.0000000000000000000000000000000000000000000004611 168.0
TLS2_k127_2385686_5 rubredoxin - - - 0.000000000000000000000000005731 109.0
TLS2_k127_2385686_6 - - - - 0.0001409 46.0
TLS2_k127_2425997_0 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 355.0
TLS2_k127_2425997_1 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005887 321.0
TLS2_k127_2425997_2 - - - - 0.0000000000000000000000000000000000009717 151.0
TLS2_k127_2425997_3 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000000000001052 112.0
TLS2_k127_2436277_0 MMPL family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 603.0
TLS2_k127_2436277_1 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 474.0
TLS2_k127_2436277_2 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000002249 229.0
TLS2_k127_2436277_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000732 196.0
TLS2_k127_2436277_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000002827 53.0
TLS2_k127_24394_0 FAD-linked oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003906 527.0
TLS2_k127_24394_1 Outer membrane receptor proteins mostly Fe transport K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 496.0
TLS2_k127_24394_2 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007986 366.0
TLS2_k127_24394_3 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000005734 221.0
TLS2_k127_24394_4 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 0.0004082 44.0
TLS2_k127_2447093_0 Methionine biosynthesis protein MetW K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000598 298.0
TLS2_k127_2447093_1 Phosphopantetheine attachment site K02078 - - 0.0000000000000000000000003231 113.0
TLS2_k127_2447093_2 pteridine-dependent deoxygenase K18240 - 4.1.3.40,4.1.3.45 0.000000000000000000003285 98.0
TLS2_k127_2465709_0 Cell division protein ftsk K03466 - - 5.883e-251 803.0
TLS2_k127_2465709_1 Recombination factor protein RarA K07478 - - 9.159e-204 645.0
TLS2_k127_2465709_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 561.0
TLS2_k127_2465709_3 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.0000000000000000000000000000000000000000000000000000000000005014 219.0
TLS2_k127_2465709_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000008141 217.0
TLS2_k127_2465709_5 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000000000000000001355 127.0
TLS2_k127_2470328_0 Oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 509.0
TLS2_k127_2470328_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 471.0
TLS2_k127_2470328_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000533 486.0
TLS2_k127_2470328_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005571 378.0
TLS2_k127_2470328_4 Surface antigen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008026 343.0
TLS2_k127_2470328_5 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.00000000000000000000000000000000000000000000000000000008576 201.0
TLS2_k127_2470328_6 Acyl CoA binding protein - - - 0.00000000000000000000000000000000000002527 145.0
TLS2_k127_2470328_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000007125 91.0
TLS2_k127_2477928_0 phospholipase C K01114 - 3.1.4.3 3.895e-199 632.0
TLS2_k127_2477928_1 transport system permease K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 593.0
TLS2_k127_2477928_2 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 347.0
TLS2_k127_2477928_3 Belongs to the HAD-like hydrolase superfamily. PhnX family K05306 - 3.11.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000002372 293.0
TLS2_k127_2477928_4 TIGRFAM phosphonate degradation operons associated HDIG domain protein K21196 - 1.13.11.78 0.0000000000000000000000000000000000000003452 161.0
TLS2_k127_2480606_0 Serine aminopeptidase, S33 K00433 - 1.11.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 471.0
TLS2_k127_2480606_1 Enoyl-(Acyl carrier protein) reductase K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 325.0
TLS2_k127_2480606_2 - - - - 0.000000000000000000000000000000001807 134.0
TLS2_k127_2480606_3 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - - 0.00001158 48.0
TLS2_k127_2501745_0 Proteasome subunit K07395 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 387.0
TLS2_k127_2501745_1 Protein of unknown function (DUF1302) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000304 258.0
TLS2_k127_2501745_2 PucR C-terminal helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007771 262.0
TLS2_k127_2512353_0 Vitamin K-dependent gamma-carboxylase - - - 8.971e-216 686.0
TLS2_k127_2512353_1 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000436 250.0
TLS2_k127_2512353_2 Preprotein translocase subunit TatD K03424 - - 0.0000000000000000000000006706 113.0
TLS2_k127_2512353_3 - - - - 0.000000000000001471 84.0
TLS2_k127_254691_0 Phosphoenolpyruvate carboxykinase - - - 6.643e-300 929.0
TLS2_k127_254691_1 chemotaxis protein K02660 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 499.0
TLS2_k127_2548632_0 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 557.0
TLS2_k127_2548632_1 dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 409.0
TLS2_k127_2548632_2 fumarylacetoacetate hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 334.0
TLS2_k127_2548632_3 protein conserved in bacteria - - - 0.00000000005553 64.0
TLS2_k127_2548632_4 Phosphoenolpyruvate carboxykinase - - - 0.0000000006665 59.0
TLS2_k127_2557516_0 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 490.0
TLS2_k127_2557516_1 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008484 394.0
TLS2_k127_2570492_0 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 478.0
TLS2_k127_2570492_1 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005303 312.0
TLS2_k127_2570492_2 Domain of unknown function (DUF4440) - - - 0.00000000000000000000000000000000000007567 162.0
TLS2_k127_2583564_0 Bacterial low temperature requirement A protein (LtrA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004123 484.0
TLS2_k127_2583564_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 391.0
TLS2_k127_2583564_2 Protein of unknown function (DUF1003) - - - 0.00000000000000000000000000000000000000000000000000000000000000001976 228.0
TLS2_k127_2583564_3 Fe-S metabolism associated K02426 - - 0.0000000000000003147 91.0
TLS2_k127_2583564_4 methylamine metabolic process K15977 - - 0.0000001681 63.0
TLS2_k127_2589916_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008873 509.0
TLS2_k127_25912_0 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006789 490.0
TLS2_k127_25912_1 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007067 329.0
TLS2_k127_25912_2 protein involved in exopolysaccharide biosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000005771 211.0
TLS2_k127_25912_3 polysaccharide biosynthetic process - - - 0.00000000000000000000000000283 129.0
TLS2_k127_2591835_0 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 328.0
TLS2_k127_2591835_1 phosphate-selective porin O and P - - - 0.00000000000000000000000000000000000000000000000000000003947 202.0
TLS2_k127_2613079_0 Carbohydrate phosphorylase - - - 0.0 1240.0
TLS2_k127_2613079_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.0 1011.0
TLS2_k127_2613079_2 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002869 572.0
TLS2_k127_2613079_3 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 463.0
TLS2_k127_2620943_0 DUF1338 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 446.0
TLS2_k127_2620943_1 Protein kinase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 449.0
TLS2_k127_2620943_2 Forkhead associated domain - - - 0.0000000002012 72.0
TLS2_k127_2620943_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0003513 52.0
TLS2_k127_2621356_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1285.0
TLS2_k127_2621356_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000002731 256.0
TLS2_k127_2621356_2 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000699 252.0
TLS2_k127_2621356_3 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins K03528 - - 0.00000000000000000000000000000000000000000000000000000000000000005773 229.0
TLS2_k127_2626092_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 6.591e-196 614.0
TLS2_k127_2626092_1 acetolactate synthase, small K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000001554 245.0
TLS2_k127_2626092_2 Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - 0.000000000000000000000001982 115.0
TLS2_k127_2626092_3 helix_turn_helix, Lux Regulon - - - 0.00000000000002628 83.0
TLS2_k127_2642353_0 Peptidase M61 - - - 2.702e-210 670.0
TLS2_k127_2642353_1 Alpha/beta hydrolase family - - - 0.000000000000000000000275 98.0
TLS2_k127_2642353_2 PFAM SMP-30 Gluconolaconase - - - 0.00009176 48.0
TLS2_k127_2643620_0 MMPL family - - - 0.0 1210.0
TLS2_k127_2643620_1 transcriptional regulator - - - 1.309e-313 984.0
TLS2_k127_2643620_2 Protein of unknown function (DUF1329) - - - 2.313e-255 794.0
TLS2_k127_2643620_3 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000009966 214.0
TLS2_k127_2643620_4 May nick specific sequences that contain T G mispairs resulting from m5C-deamination K07458 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0043170,GO:0043765,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.00000000000000000000000001349 109.0
TLS2_k127_2652776_0 cellulose binding - - - 2.343e-208 667.0
TLS2_k127_2683971_0 fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 510.0
TLS2_k127_2683971_1 Cellulase (glycosyl hydrolase family 5) K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 334.0
TLS2_k127_270690_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 459.0
TLS2_k127_270690_1 endoribonuclease - - - 0.0000000000000000000000000000000000000000000000000000000004969 203.0
TLS2_k127_270690_2 Zinc metalloprotease (Elastase) K01399,K08604 - 3.4.24.25,3.4.24.26 0.0000000000000000000000000000000000000000005654 164.0
TLS2_k127_2724583_0 acetoin utilization protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 390.0
TLS2_k127_2724583_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 298.0
TLS2_k127_2724583_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000008577 149.0
TLS2_k127_2729665_0 Transporter K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005102 422.0
TLS2_k127_2729665_1 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 406.0
TLS2_k127_2729665_2 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 357.0
TLS2_k127_2729665_3 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001984 275.0
TLS2_k127_2729665_4 Thrombospondin type 3 repeat - - - 0.00000000000000000000000000000000000000000000000000000000001408 223.0
TLS2_k127_2729665_5 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000000000000002336 185.0
TLS2_k127_2729665_6 Acetyltransferase (GNAT) domain - - - 0.000000000000000001836 95.0
TLS2_k127_2729665_7 ABC-2 family transporter protein K01992 - - 0.00000000000001087 75.0
TLS2_k127_2741197_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0 1199.0
TLS2_k127_2741197_1 acyl-coa dehydrogenase K09456 - - 8.886e-267 837.0
TLS2_k127_2741197_2 PFAM Metal-dependent phosphohydrolase, HD - - - 0.0000000000000000000000000000000000006376 151.0
TLS2_k127_2781499_0 Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present K03657 - 3.6.4.12 1.5e-323 1002.0
TLS2_k127_2781499_1 TonB dependent receptor - - - 0.0000000000000000000000000007058 114.0
TLS2_k127_2787660_0 2,4-dienoyl-coa reductase K00219 - 1.3.1.34 1.183e-289 904.0
TLS2_k127_2787660_1 - - - - 0.0000001124 53.0
TLS2_k127_2793792_0 ArsR family transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005919 395.0
TLS2_k127_2793792_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 326.0
TLS2_k127_2793792_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002987 274.0
TLS2_k127_2793792_3 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000006753 256.0
TLS2_k127_2793792_4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000228 240.0
TLS2_k127_2797352_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 602.0
TLS2_k127_2807082_0 COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog - - - 5.213e-282 887.0
TLS2_k127_2807082_1 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 606.0
TLS2_k127_2807082_2 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 301.0
TLS2_k127_2807082_3 Peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000968 201.0
TLS2_k127_2807082_4 COG2346 Truncated hemoglobins K06886 - - 0.00000000000000000000324 94.0
TLS2_k127_2807082_5 Glutaredoxin - - - 0.000000618 51.0
TLS2_k127_2814441_0 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 1.725e-217 700.0
TLS2_k127_2814441_1 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 532.0
TLS2_k127_2814441_2 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009482 422.0
TLS2_k127_2814441_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007497 349.0
TLS2_k127_2814441_4 Phosphotransferase K07102 - 2.7.1.221 0.0000000000000000000000000000000000000004349 158.0
TLS2_k127_2828213_0 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 407.0
TLS2_k127_2828213_1 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 432.0
TLS2_k127_2828213_2 Protein of unknown function (DUF1415) K09941 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000527 247.0
TLS2_k127_2828213_3 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000001711 231.0
TLS2_k127_2828213_4 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.000000000000000000000000000000009879 129.0
TLS2_k127_2831016_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009509 545.0
TLS2_k127_2831016_1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 484.0
TLS2_k127_2831016_2 depolymerase K03932 - - 0.000000000000000000000000000000000000000000000000000000000004069 220.0
TLS2_k127_2831016_3 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001706 202.0
TLS2_k127_2831016_4 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000002979 199.0
TLS2_k127_2831016_5 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000001247 130.0
TLS2_k127_2831016_6 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000002017 107.0
TLS2_k127_2832639_0 TonB dependent receptor - - - 3.019e-301 949.0
TLS2_k127_2832639_1 Major facilitator Superfamily K03292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 548.0
TLS2_k127_2832639_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007412 494.0
TLS2_k127_2832639_3 Putative serine dehydratase domain K01753 - 4.3.1.18 0.00000000000000000000000000000000000832 138.0
TLS2_k127_2844926_0 Belongs to the beta-ketoacyl-ACP synthases family K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004222 610.0
TLS2_k127_2844926_1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000785 332.0
TLS2_k127_2844926_2 COG0644 Dehydrogenases (flavoproteins) - - - 0.000000000000000000000000000000000000000000000000000000000002648 212.0
TLS2_k127_2844926_3 Protein of unknown function DUF45 - - - 0.000000000000000000000000000000000000000000000000000000007065 205.0
TLS2_k127_2844926_4 excinuclease, ATPase subunit - - - 0.0000000000000000000000000000000000000000000016 168.0
TLS2_k127_2844926_5 - - - - 0.000000000000000000000000000000003213 132.0
TLS2_k127_2844926_6 Protein of unknown function (DUF3261) - - - 0.00000000000000000000000000000003355 136.0
TLS2_k127_2844926_7 3-hydroxylacyl-(Acyl carrier protein) dehydratase - - - 0.0000000000000000000000000003201 124.0
TLS2_k127_2844926_8 - - - - 0.00000000217 65.0
TLS2_k127_2874767_0 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 2.287e-259 816.0
TLS2_k127_2874767_1 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004338 358.0
TLS2_k127_2874767_2 Lipase (class 2) - - - 0.00000000000000000000005102 115.0
TLS2_k127_2874767_3 Protein involved in MetA-pathway of phenol - - - 0.0005671 52.0
TLS2_k127_288510_0 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 466.0
TLS2_k127_288510_1 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000723 253.0
TLS2_k127_288510_2 Cobalamin synthesis protein cobW C-terminal domain - - - 0.000000000000000000000000000000000000000000000000001354 184.0
TLS2_k127_2906474_0 MMPL family - - - 6.072e-226 724.0
TLS2_k127_2906474_1 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007504 599.0
TLS2_k127_2906474_2 gamma-glutamyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004359 406.0
TLS2_k127_2906474_3 membrane protein HpnM K07323 - - 0.000000000000000000000000000000000000009512 152.0
TLS2_k127_2910699_0 Carbohydrate ABC transporter ATP-binding protein, CUT1 family K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000168 285.0
TLS2_k127_2910699_1 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000002305 250.0
TLS2_k127_2910699_2 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000001134 99.0
TLS2_k127_2923938_0 Inhibitor of apoptosis-promoting Bax1 K19416 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016021,GO:0019222,GO:0030162,GO:0031224,GO:0044425,GO:0044464,GO:0050789,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071944,GO:0080090 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001621 265.0
TLS2_k127_2923938_1 PFAM MltA-interacting MipA family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001927 247.0
TLS2_k127_2927098_0 GGDEF domain - - - 0.0 1154.0
TLS2_k127_2927098_1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 319.0
TLS2_k127_2927098_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000004311 241.0
TLS2_k127_2927098_3 Protein of unknown function (DUF3309) - - - 0.00000000000000000003204 91.0
TLS2_k127_2946677_0 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007698 498.0
TLS2_k127_2946677_1 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007474 360.0
TLS2_k127_2946677_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005865 342.0
TLS2_k127_2946677_3 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008777 301.0
TLS2_k127_2946677_4 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000908 180.0
TLS2_k127_2964275_0 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000003986 193.0
TLS2_k127_2964275_1 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000008385 193.0
TLS2_k127_2964275_2 Succinylarginine dihydrolase K01484 - 3.5.3.23 0.000000000000000000000000000008165 119.0
TLS2_k127_2964275_3 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins - - - 0.0009263 49.0
TLS2_k127_2982277_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 392.0
TLS2_k127_2982277_1 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003252 254.0
TLS2_k127_2991137_0 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 379.0
TLS2_k127_2991137_1 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 340.0
TLS2_k127_2991137_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001809 233.0
TLS2_k127_2991137_3 Oxidoreductase FAD-binding domain K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000003112 173.0
TLS2_k127_2992164_0 cellulose synthase K20541 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 353.0
TLS2_k127_2992164_1 cellulose synthase operon C domain protein K20543 - - 0.0000000000000000000000000000000000000002704 166.0
TLS2_k127_3018691_0 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365 - 2.4.1.129,3.4.16.4 5.254e-308 961.0
TLS2_k127_3018691_1 Binding-protein-dependent transport system inner membrane component - - - 1.858e-243 773.0
TLS2_k127_3018691_2 phosphate transport system permease - - - 4.206e-234 736.0
TLS2_k127_3018691_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 443.0
TLS2_k127_3018691_4 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004529 383.0
TLS2_k127_3064663_0 PFAM Neutral alkaline nonlysosomal ceramidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009827 535.0
TLS2_k127_3064663_1 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 310.0
TLS2_k127_3064663_4 PFAM Transposase DDE domain - - - 0.00003834 49.0
TLS2_k127_3065353_0 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 437.0
TLS2_k127_3065353_1 glutathione s-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 317.0
TLS2_k127_3065353_2 SnoaL-like domain - - - 0.000000000000000000000000000000000000000001982 162.0
TLS2_k127_3070651_0 Protein of unknown function (DUF1329) - - - 1.221e-236 742.0
TLS2_k127_3070651_1 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 530.0
TLS2_k127_3070651_2 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000755 233.0
TLS2_k127_3070651_3 Protein of unknown function (DUF1302) - - - 0.00000000000000000000000000000000000000000001906 165.0
TLS2_k127_309874_0 Protein of unknown function (DUF1329) - - - 1.307e-224 704.0
TLS2_k127_309874_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 4.01e-207 653.0
TLS2_k127_309874_2 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000611 469.0
TLS2_k127_309874_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000004425 231.0
TLS2_k127_309874_4 Sulfotransferase family - - - 0.00000000000000000000000000000000000000000000000000003735 201.0
TLS2_k127_3144636_0 Protein of unknown function (DUF1302) - - - 2.984e-260 815.0
TLS2_k127_3144636_1 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 4.436e-246 774.0
TLS2_k127_3144636_10 signal transduction - - - 0.000000000000000000000000000000000000000000002086 184.0
TLS2_k127_3144636_11 Belongs to the transcriptional regulatory Fis family K03557 GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0032991,GO:0032993,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815 - 0.000000000000000000000000000000104 126.0
TLS2_k127_3144636_12 Forkhead associated domain - - - 0.0000000000009794 78.0
TLS2_k127_3144636_13 - - - - 0.0008164 48.0
TLS2_k127_3144636_2 In Escherichia coli this enzyme appears to be an NAD NADP -dependent succinate semialdehyde dehydrogenase K00135,K08324 - 1.2.1.16,1.2.1.20,1.2.1.24,1.2.1.79 2.665e-234 737.0
TLS2_k127_3144636_3 Protein of unknown function (DUF1329) - - - 5.081e-231 724.0
TLS2_k127_3144636_4 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 9.122e-221 696.0
TLS2_k127_3144636_5 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 539.0
TLS2_k127_3144636_6 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 474.0
TLS2_k127_3144636_7 Methylates ribosomal protein L11 K02687 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007321 382.0
TLS2_k127_3144636_8 May be involved in recombination K03554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 336.0
TLS2_k127_3144636_9 transcriptional regulator K09017,K22105 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000006148 252.0
TLS2_k127_3182236_0 Belongs to the short-chain dehydrogenases reductases (SDR) family K14189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008085 360.0
TLS2_k127_3182236_1 Pkd domain containing protein K01337 - 3.4.21.50 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002513 321.0
TLS2_k127_3182236_2 Uncharacterised 5xTM membrane BCR, YitT family COG1284 - - - 0.000000000000000000000000000000000000000000000000000000000000002895 222.0
TLS2_k127_3182236_3 regulation of RNA biosynthetic process - - - 0.0000000000000000000000000000000000000000000000001078 181.0
TLS2_k127_319102_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 599.0
TLS2_k127_319102_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 510.0
TLS2_k127_319102_2 Prephenate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 370.0
TLS2_k127_319102_3 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007474 287.0
TLS2_k127_319102_4 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000009864 239.0
TLS2_k127_3194631_0 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate K00381 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016667,GO:0016673,GO:0019419,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0050311,GO:0055114 1.8.1.2 2.097e-296 915.0
TLS2_k127_3194631_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 506.0
TLS2_k127_3194631_2 - - - - 0.00000000000000000000002957 106.0
TLS2_k127_3194631_3 Bacterial protein of unknown function (DUF934) - - - 0.000000000000000000002215 101.0
TLS2_k127_3194631_4 Sulfite exporter TauE/SafE - - - 0.00000008472 55.0
TLS2_k127_3214435_0 mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth K15738 - - 6.306e-223 708.0
TLS2_k127_3218749_0 Acetyl-coenzyme A synthetase N-terminus - - - 0.0 1129.0
TLS2_k127_3218749_1 oxidase, subunit K00425 - 1.10.3.14 2.347e-318 979.0
TLS2_k127_3218749_10 Protein of unknown function (DUF3237) - - - 0.00000000000000000000000000000000000000000000000000002259 210.0
TLS2_k127_3218749_11 helix_turn_helix, cAMP Regulatory protein - - - 0.00000000000000000000000000000000000000000000003621 178.0
TLS2_k127_3218749_12 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000004474 158.0
TLS2_k127_3218749_2 Saccharopine dehydrogenase NADP binding domain - - - 7.952e-220 686.0
TLS2_k127_3218749_3 Sigma-54 interaction domain - - - 1.843e-199 631.0
TLS2_k127_3218749_5 Lactonase, 7-bladed beta-propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008616 544.0
TLS2_k127_3218749_6 Zn-dependent hydrolases including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 473.0
TLS2_k127_3218749_7 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006355 414.0
TLS2_k127_3218749_8 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008711 249.0
TLS2_k127_3218749_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001199 248.0
TLS2_k127_3221134_0 Belongs to the TrpC family K01609 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 366.0
TLS2_k127_3221134_1 Transcriptional regulator K10914 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0017076,GO:0019001,GO:0019219,GO:0019222,GO:0030551,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032561,GO:0035438,GO:0036094,GO:0043167,GO:0043168,GO:0046983,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002787 273.0
TLS2_k127_3221134_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000005953 218.0
TLS2_k127_3221134_3 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.000000000000000000000000000000000000000000000000000000000007802 208.0
TLS2_k127_3221134_4 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000008797 209.0
TLS2_k127_32295_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006901 301.0
TLS2_k127_32295_1 PFAM membrane protein of K08972 - - 0.00000000000000000000000000001864 121.0
TLS2_k127_32295_2 Glutamate synthase K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000007789 115.0
TLS2_k127_32295_3 - - - - 0.0000000000000002585 86.0
TLS2_k127_3229591_0 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 2.732e-263 817.0
TLS2_k127_3229591_1 Histidine kinase K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 320.0
TLS2_k127_3229591_2 regulator K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001477 269.0
TLS2_k127_3229591_3 FR47-like protein - - - 0.0000000000000000000000000000000000000006855 155.0
TLS2_k127_3238358_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1172.0
TLS2_k127_3248279_0 homogentisate 1,2-dioxygenase - - - 1.695e-194 610.0
TLS2_k127_3248279_1 2-keto-4-pentenoate hydratase K16171 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 511.0
TLS2_k127_3248279_2 maleylacetoacetate isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002279 272.0
TLS2_k127_3261377_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008032 244.0
TLS2_k127_3261377_1 - - - - 0.000000000000000003472 97.0
TLS2_k127_3261574_0 Protein of unknown function (DUF1302) - - - 2.524e-233 739.0
TLS2_k127_3261574_1 Reductase C-terminal K00529 - 1.18.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 538.0
TLS2_k127_3261574_2 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 520.0
TLS2_k127_3261574_3 Lipase (class 2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 405.0
TLS2_k127_3261574_4 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000000000000000000000000000001891 133.0
TLS2_k127_3261574_5 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00004587 46.0
TLS2_k127_3265566_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 9.822e-310 962.0
TLS2_k127_3265566_1 Diguanylate cyclase K13069 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 447.0
TLS2_k127_3265566_2 Belongs to the ParA family K04562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 375.0
TLS2_k127_3265566_3 flagellar K02404 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 347.0
TLS2_k127_3265566_4 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 314.0
TLS2_k127_3265566_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003591 281.0
TLS2_k127_3265566_6 response regulator K03413 - - 0.000000000000000000000000000000000000000000000000000000000002462 214.0
TLS2_k127_3265566_7 Chemotaxis phosphatase, CheZ - - - 0.00000000000000000000000000005319 126.0
TLS2_k127_3265566_8 CHASE3 domain - - - 0.00000002161 57.0
TLS2_k127_3280188_0 TonB dependent receptor K16089 - - 1.074e-201 647.0
TLS2_k127_3280188_1 multicopper - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 567.0
TLS2_k127_3280188_3 Heme iron utilization protein K07226 - - 0.0000000000000000000000000000000000000000000000000000000000000001443 230.0
TLS2_k127_3280188_4 Putative beta-barrel porin 2 - - - 0.000000000000000000000000003267 126.0
TLS2_k127_328095_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1144.0
TLS2_k127_328095_1 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 2.07e-217 687.0
TLS2_k127_328095_2 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 467.0
TLS2_k127_328095_3 Biotin-lipoyl like - - - 0.0000000000000000000000000000000000000000702 160.0
TLS2_k127_3282558_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 3.845e-252 783.0
TLS2_k127_3282558_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004925 573.0
TLS2_k127_3282558_2 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009813 437.0
TLS2_k127_3282558_3 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005092 438.0
TLS2_k127_3282558_4 Nudix N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 302.0
TLS2_k127_3282558_5 - - - - 0.000000000000000000000000000000000009286 140.0
TLS2_k127_3282558_6 epimerase dehydratase K08679 - 5.1.3.6 0.00000000000000138 76.0
TLS2_k127_3298096_0 Cellulose biosynthesis protein BcsG - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 515.0
TLS2_k127_3298096_1 Cellulose synthase K00694 - 2.4.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 494.0
TLS2_k127_3315847_0 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 400.0
TLS2_k127_3315847_1 Belongs to the short-chain dehydrogenases reductases (SDR) family K16066 - 1.1.1.381 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004282 361.0
TLS2_k127_3322319_0 TonB dependent receptor - - - 9.877e-223 713.0
TLS2_k127_3322319_1 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000006377 151.0
TLS2_k127_3342629_0 MMPL family - - - 0.0 1377.0
TLS2_k127_3342629_1 Protein of unknown function (DUF1302) - - - 2.132e-294 918.0
TLS2_k127_3342629_2 Protein of unknown function (DUF1329) - - - 1.378e-249 774.0
TLS2_k127_3342629_3 Serine threonine-protein kinase pknK K13419 - 2.7.11.1 0.0000000000000000006753 99.0
TLS2_k127_3355848_0 His Kinase A (phosphoacceptor) domain - - - 8.502e-228 714.0
TLS2_k127_3355848_1 HupE / UreJ protein - - - 0.00000000000000001191 85.0
TLS2_k127_3362944_0 peptidase - - - 1.787e-243 760.0
TLS2_k127_3362944_1 aminopeptidase - - - 3.503e-230 725.0
TLS2_k127_3362944_2 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007209 250.0
TLS2_k127_3362944_3 PFAM metallophosphoesterase K07098 - - 0.00002705 47.0
TLS2_k127_3363177_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007,K21787 - 2.7.9.2 3.905e-290 902.0
TLS2_k127_3363177_1 PhoD-like phosphatase, N-terminal domain K01113 - 3.1.3.1 5.359e-194 621.0
TLS2_k127_3363177_2 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 405.0
TLS2_k127_3428201_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 7.776e-195 616.0
TLS2_k127_3428201_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 631.0
TLS2_k127_3428201_2 Periplasmic binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 349.0
TLS2_k127_3428201_3 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 336.0
TLS2_k127_3428201_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004847 327.0
TLS2_k127_3428201_5 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000117 285.0
TLS2_k127_3428201_6 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000003134 259.0
TLS2_k127_3428201_7 - - - - 0.0000000000000000000000000000000000000000000000000000004771 205.0
TLS2_k127_3428201_8 Protein of unknown function (DUF2384) - - - 0.00000000003237 66.0
TLS2_k127_342934_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 4.12e-219 689.0
TLS2_k127_342934_1 cAMP phosphodiesterases class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 361.0
TLS2_k127_342934_2 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000000000000000000000001938 131.0
TLS2_k127_342934_3 - - - - 0.00000000000000000000000379 108.0
TLS2_k127_342934_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000001547 70.0
TLS2_k127_3438522_0 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004326 520.0
TLS2_k127_3438522_1 Aminotransferase class-V K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 439.0
TLS2_k127_3438522_2 TIGRFAM Serine O-acetyltransferase K00640 - 2.3.1.30 0.000001395 51.0
TLS2_k127_3445676_0 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 438.0
TLS2_k127_3445676_1 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005708 311.0
TLS2_k127_3456527_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 9.25e-217 680.0
TLS2_k127_3456527_1 component I K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 525.0
TLS2_k127_3456527_2 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 344.0
TLS2_k127_3456527_3 Amino-transferase class IV K02619 - 4.1.3.38 0.00000000000000000000000000000000000000000000000000000000001373 220.0
TLS2_k127_3456527_4 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000001863 199.0
TLS2_k127_3456527_5 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000000000000000000000000000001223 133.0
TLS2_k127_347632_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005966 327.0
TLS2_k127_347632_1 Glutamine cyclotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001956 246.0
TLS2_k127_347632_2 stress-induced protein - - - 0.000000000000000000000000000000000000000000000000000000000000004202 226.0
TLS2_k127_3476429_0 Putative vitamin uptake transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 356.0
TLS2_k127_3476429_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008499 311.0
TLS2_k127_3476429_2 Glycoside hydrolase, family 19 - - - 0.000000000000000000000000000000000000000000000000000000000007069 219.0
TLS2_k127_3476429_3 Belongs to the ompA family - - - 0.0000000000000001352 94.0
TLS2_k127_3476429_4 Protein of unknown function (DUF3106) - - - 0.00000000002251 72.0
TLS2_k127_3477375_0 Protein of unknown function (DUF1302) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 460.0
TLS2_k127_3477375_1 Photosynthesis system II assembly factor YCF48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 349.0
TLS2_k127_3477375_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000001224 154.0
TLS2_k127_3488431_0 Periplasmic sensor domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 442.0
TLS2_k127_3488431_1 Domain of unknown function (DUF4154) - - - 0.00000004037 61.0
TLS2_k127_3490808_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 7.686e-277 857.0
TLS2_k127_3490808_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.738e-271 846.0
TLS2_k127_3490808_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 440.0
TLS2_k127_3490808_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007904 405.0
TLS2_k127_3490808_4 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004107 265.0
TLS2_k127_3490808_5 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000000000000000000000000003018 209.0
TLS2_k127_3490808_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000000000000000004019 191.0
TLS2_k127_3490808_7 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000000001049 171.0
TLS2_k127_3490808_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000000000000000001132 148.0
TLS2_k127_3506728_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.0 1154.0
TLS2_k127_3506728_1 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000002902 223.0
TLS2_k127_3506728_2 Uncharacterized ACR, YdiU/UPF0061 family - - - 0.000000000000002057 77.0
TLS2_k127_352902_0 X-Pro dipeptidyl-peptidase (S15 family) - - - 2.464e-263 826.0
TLS2_k127_3549284_0 Pyrimidine nucleoside phosphorylase C-terminal domain - - - 1.069e-194 641.0
TLS2_k127_3549284_1 Pyrimidine nucleoside phosphorylase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 597.0
TLS2_k127_3549284_2 Belongs to the ribose-phosphate pyrophosphokinase family K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006435 342.0
TLS2_k127_3549284_3 Glutathione S-transferase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000006233 180.0
TLS2_k127_3549284_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000001154 162.0
TLS2_k127_3549284_5 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000005142 139.0
TLS2_k127_3567406_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 431.0
TLS2_k127_3567406_1 Putative SAM-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005943 248.0
TLS2_k127_3602361_0 Bacterial protein of unknown function (DUF885) - - - 3.929e-233 736.0
TLS2_k127_3602361_1 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA K12297 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.173,2.1.1.264 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007764 524.0
TLS2_k127_3613417_0 Iron-regulated membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001062 244.0
TLS2_k127_3613417_1 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000009016 207.0
TLS2_k127_3636249_0 TIGRFAM type I secretion outer membrane protein, TolC family K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 334.0
TLS2_k127_3636249_1 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000001027 185.0
TLS2_k127_3636249_2 Rhodanese Homology Domain - - - 0.000000000000000000000000000000225 125.0
TLS2_k127_3636803_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003829 548.0
TLS2_k127_3636803_1 transport protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007872 458.0
TLS2_k127_3636803_2 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 454.0
TLS2_k127_3636803_3 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 399.0
TLS2_k127_3636803_4 peptidoglycan-binding protein, lysm - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 390.0
TLS2_k127_3636803_5 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000003985 233.0
TLS2_k127_3636803_6 ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000001171 210.0
TLS2_k127_3657005_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000005485 211.0
TLS2_k127_3657005_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000129 136.0
TLS2_k127_3657005_2 glycosyl transferase - - - 0.00000000000000000000009969 106.0
TLS2_k127_3663429_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 4.093e-246 769.0
TLS2_k127_3663429_1 Flavin containing amine oxidoreductase - - - 1.984e-210 667.0
TLS2_k127_3663429_2 Cache domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008125 447.0
TLS2_k127_3663429_3 6-pyruvoyl tetrahydropterin synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 337.0
TLS2_k127_3663429_4 Antibiotic biosynthesis monooxygenase K09932 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008005 301.0
TLS2_k127_3663429_5 Histidine biosynthesis bifunctional protein HisIE K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 289.0
TLS2_k127_3663429_6 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000927 258.0
TLS2_k127_3663429_7 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.000000000000000000000000000000000000000009418 158.0
TLS2_k127_3681172_0 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000815 398.0
TLS2_k127_3681172_1 Protein of unknown function (DUF1298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 392.0
TLS2_k127_3684648_0 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 352.0
TLS2_k127_3684648_1 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 0.00000000000000000000000000000000000000000000000000000000000009671 222.0
TLS2_k127_3684648_2 Integral membrane protein (DUF2244) - - - 0.000000000000000000000000000000000000000004572 166.0
TLS2_k127_3684648_3 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47 0.00000000009036 62.0
TLS2_k127_3700875_0 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 3.667e-226 703.0
TLS2_k127_3700875_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006783 448.0
TLS2_k127_3700875_2 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 431.0
TLS2_k127_3700875_3 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001683 277.0
TLS2_k127_3700875_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000007574 213.0
TLS2_k127_3700875_5 Alkylphosphonate utilization operon protein PhnA K06193 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000005891 163.0
TLS2_k127_3700875_6 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000000000000000000006323 150.0
TLS2_k127_3700875_7 HsdM N-terminal domain K03427 - 2.1.1.72 0.0000000000000000000000000000000004558 132.0
TLS2_k127_3711179_0 NMT1-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004902 571.0
TLS2_k127_3711179_1 Protein of unknown function (DUF3034) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 508.0
TLS2_k127_3711179_10 FMN_bind - - - 0.00000000000000000000000000000000000000000000000000000000000000002632 234.0
TLS2_k127_3711179_11 biopolymer transport protein - - - 0.0000000000000000000000000000000000007749 152.0
TLS2_k127_3711179_12 biopolymer transport protein - - - 0.00000000000000000000000000000000001344 141.0
TLS2_k127_3711179_2 Cupredoxin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006051 492.0
TLS2_k127_3711179_3 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 384.0
TLS2_k127_3711179_4 PepSY-associated TM region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007424 338.0
TLS2_k127_3711179_5 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 325.0
TLS2_k127_3711179_6 ANTAR K07183 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003764 282.0
TLS2_k127_3711179_7 COG2346, Truncated hemoglobins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009377 242.0
TLS2_k127_3711179_8 MotA/TolQ/ExbB proton channel family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000568 240.0
TLS2_k127_3711179_9 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000003133 249.0
TLS2_k127_3715611_0 Ammonium transporter K03320 - - 4.782e-222 698.0
TLS2_k127_3715611_1 Among the AAA ATPases, the YifB protease family belongs to the Helix 2 insert clade K07391 - - 3.866e-215 678.0
TLS2_k127_3715611_10 SURF4 family - - - 0.000000000000000000000000000000001193 134.0
TLS2_k127_3715611_11 protein conserved in bacteria K09806 - - 0.000000000000000000000000335 115.0
TLS2_k127_3715611_12 endonuclease containing a URI domain K07461 - - 0.0000000000000000000000003732 112.0
TLS2_k127_3715611_2 Putative Na+/H+ antiporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 520.0
TLS2_k127_3715611_3 Dihydrouridine synthase (Dus) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004684 499.0
TLS2_k127_3715611_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007577 474.0
TLS2_k127_3715611_5 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 396.0
TLS2_k127_3715611_6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity K01118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000648 282.0
TLS2_k127_3715611_7 at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA) K04751,K04752 - - 0.00000000000000000000000000000000000000000000000000000000005673 208.0
TLS2_k127_3715611_8 Bacterial protein of unknown function (Gcw_chp) - - - 0.0000000000000000000000000000000000000000000000000000000008949 209.0
TLS2_k127_3715611_9 cytochrome - - - 0.000000000000000000000000000000000000000000005716 170.0
TLS2_k127_3773674_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 1.037e-203 640.0
TLS2_k127_3773674_1 Major Facilitator Superfamily - - - 2.657e-203 646.0
TLS2_k127_3773674_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 556.0
TLS2_k127_3773674_3 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000000000003269 211.0
TLS2_k127_3784515_0 cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 450.0
TLS2_k127_3784515_1 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 423.0
TLS2_k127_3784515_2 PFAM NUDIX hydrolase K03207 - - 0.000000000000000002783 86.0
TLS2_k127_3787381_0 diguanylate cyclase - - - 6.419e-240 762.0
TLS2_k127_3787381_1 Cytochrome P450 - - - 1.058e-239 747.0
TLS2_k127_3787381_2 Major facilitator superfamily K08218 - - 1.099e-219 687.0
TLS2_k127_3787381_3 Protein of unknown function (DUF2834) - - - 0.000000000000000000000000000000000000000000000000000000000001231 213.0
TLS2_k127_3793834_0 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 432.0
TLS2_k127_3793834_1 transferase K01028 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 390.0
TLS2_k127_3793834_2 transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 349.0
TLS2_k127_3793834_3 Hydroxymethylglutaryl-CoA lyase K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000006707 255.0
TLS2_k127_3793834_4 protein conserved in bacteria K09966 - - 0.000000000000201 70.0
TLS2_k127_3793834_5 - - - - 0.0005876 47.0
TLS2_k127_3800560_0 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03669 GO:0005575,GO:0016020 - 1.075e-301 945.0
TLS2_k127_3800560_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 386.0
TLS2_k127_3800560_2 acetyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000002641 271.0
TLS2_k127_3800560_3 CoA binding domain K06929 - - 0.000000000000000000000000000000000000000000000000000000001322 203.0
TLS2_k127_3800560_4 Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs) K03670 - - 0.00000000000000000000000000000000000000000000000000006072 192.0
TLS2_k127_3832504_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 476.0
TLS2_k127_3832504_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005396 258.0
TLS2_k127_3832504_2 glutathione s-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000004528 226.0
TLS2_k127_3832504_3 glutathione s-transferase - - - 0.0000000000000000000000000000000000000000000000000007236 187.0
TLS2_k127_3832504_4 - - - - 0.000000000003144 78.0
TLS2_k127_3832954_0 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 593.0
TLS2_k127_3832954_1 OmpA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007613 433.0
TLS2_k127_3832954_2 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 337.0
TLS2_k127_3832954_3 Redoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002151 262.0
TLS2_k127_3832954_4 Protein of unknown function (DUF2914) - - - 0.00000000000000000000000000000000000000000000000000000000000000000007786 244.0
TLS2_k127_3832954_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000085 237.0
TLS2_k127_3832954_6 NlpC/P60 family - - - 0.00000000000000000000007398 104.0
TLS2_k127_3832954_7 - - - - 0.0000000000000008908 85.0
TLS2_k127_3844188_0 Protein of unknown function (DUF1302) - - - 9.015e-271 854.0
TLS2_k127_3844188_1 Protein of unknown function (DUF1329) - - - 7.189e-223 698.0
TLS2_k127_3844188_2 ABC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 605.0
TLS2_k127_3844188_3 Protein of unknown function (DUF445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 536.0
TLS2_k127_3844188_4 Protein of unknown function (DUF2505) - - - 0.0000000000000000000000000000000000000001163 156.0
TLS2_k127_3844188_5 - - - - 0.00000000000000000000000000000000000009236 149.0
TLS2_k127_3844188_6 Protein of unknown function (DUF2970) - - - 0.00002064 51.0
TLS2_k127_3865050_0 TonB-dependent Receptor Plug K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 311.0
TLS2_k127_3865050_1 adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000004325 183.0
TLS2_k127_3866569_0 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009453 445.0
TLS2_k127_3866569_1 Biogenesis protein K09792 - - 0.000000000000000000000000000000008065 136.0
TLS2_k127_3866569_2 zinc ion binding K06204 - - 0.0000000000000000001315 94.0
TLS2_k127_3866569_3 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 0.00000000000000001564 85.0
TLS2_k127_3883510_0 carboxylase - - - 6.855e-230 724.0
TLS2_k127_3883510_1 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001275 239.0
TLS2_k127_3887473_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007439 316.0
TLS2_k127_3887473_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 298.0
TLS2_k127_3887473_2 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 293.0
TLS2_k127_3891060_0 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008535 499.0
TLS2_k127_3891060_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000004767 239.0
TLS2_k127_3891060_2 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.00000000004451 64.0
TLS2_k127_3893557_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009433 415.0
TLS2_k127_3893557_1 ANTAR K07183 - - 0.0000000000000000000000000000000000001083 149.0
TLS2_k127_3893557_2 Tetratricopeptide repeat - - - 0.00000000000000000000000006723 109.0
TLS2_k127_3893557_3 Transcriptional regulator - - - 0.00000005334 55.0
TLS2_k127_3894655_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1069.0
TLS2_k127_3894655_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 4.515e-255 791.0
TLS2_k127_3894655_2 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007037 290.0
TLS2_k127_3894655_3 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000001872 143.0
TLS2_k127_3894655_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000004103 126.0
TLS2_k127_3897954_0 SapC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007918 279.0
TLS2_k127_3897954_1 COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000001706 223.0
TLS2_k127_3897954_2 PFAM FecR protein - - - 0.000000000000000000000000000000000000000009558 166.0
TLS2_k127_3897954_3 pathogenesis - - - 0.00000007154 67.0
TLS2_k127_3901388_0 Predicted metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007579 354.0
TLS2_k127_3901388_1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 285.0
TLS2_k127_3901388_2 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000001903 200.0
TLS2_k127_3901388_3 - - - - 0.0000000000000000000000000000000000000000004071 170.0
TLS2_k127_3901388_4 - - - - 0.0000355 46.0
TLS2_k127_3903776_0 COG1530 Ribonucleases G and E K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009891 571.0
TLS2_k127_3903776_1 DNA-(Apurinic or apyrimidinic site) lyase K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 399.0
TLS2_k127_3903776_2 Chemotaxis protein histidine kinase and related kinases K02487,K06596 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 374.0
TLS2_k127_3903776_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001051 289.0
TLS2_k127_3903776_4 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000002795 209.0
TLS2_k127_3903776_5 Two component signalling adaptor domain K06598 - - 0.000000000000000000000000000000000000000512 153.0
TLS2_k127_3903776_6 - - - - 0.0000000000000000000000007944 112.0
TLS2_k127_3911069_0 Protein of unknown function (DUF1302) - - - 2.347e-197 634.0
TLS2_k127_3911069_1 Protein of unknown function (DUF1214) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 582.0
TLS2_k127_3911069_2 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009435 553.0
TLS2_k127_3911069_3 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 427.0
TLS2_k127_3911069_4 EthD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008783 254.0
TLS2_k127_3911069_5 membrane protein domain - - - 0.0000000000000000000000000000000000000000000000000000000248 201.0
TLS2_k127_3911069_6 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000001921 176.0
TLS2_k127_3911069_7 Protein of unknown function (DUF1304) K08987 - - 0.0000000000000000000000000000000000000000000001663 170.0
TLS2_k127_3917595_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1207.0
TLS2_k127_3917595_1 aminotransferase K14261 - - 1.375e-244 764.0
TLS2_k127_3917595_10 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008467 258.0
TLS2_k127_3917595_11 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000001508 254.0
TLS2_k127_3917595_12 membrane K06194 - - 0.0000000000000000000000000000000000000000000000000000000000000000003443 239.0
TLS2_k127_3917595_13 Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000006297 238.0
TLS2_k127_3917595_14 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.1.3.5 0.0000000000000000000000000000000000000000000000004904 177.0
TLS2_k127_3917595_15 Hemin uptake protein hemP - - - 0.000000001277 61.0
TLS2_k127_3917595_16 - - - - 0.0000009381 53.0
TLS2_k127_3917595_2 Single-stranded-DNA-specific exonuclease K07462 - - 5.788e-223 705.0
TLS2_k127_3917595_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 1.651e-205 646.0
TLS2_k127_3917595_4 Homoserine dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005863 610.0
TLS2_k127_3917595_5 Pyridoxal-phosphate dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 569.0
TLS2_k127_3917595_6 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000902 531.0
TLS2_k127_3917595_7 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 542.0
TLS2_k127_3917595_8 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 331.0
TLS2_k127_3917595_9 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005675 334.0
TLS2_k127_3930085_0 Carboxypeptidase - - - 7.573e-226 713.0
TLS2_k127_3930085_1 Protein of unknown function (DUF1501) - - - 0.000000000000000000000000000000000000000000000000000000000002018 223.0
TLS2_k127_393115_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000001954 272.0
TLS2_k127_393115_1 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001464 255.0
TLS2_k127_393115_2 SelR domain K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000001816 230.0
TLS2_k127_393115_3 Glutamine amidotransferase class-I - - - 0.00000000000000000000000000001502 119.0
TLS2_k127_3936201_0 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003211 288.0
TLS2_k127_3936201_1 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000008983 234.0
TLS2_k127_3936201_2 Protein conserved in bacteria K09931 - - 0.00000000000000000000000000000000000001307 153.0
TLS2_k127_394153_0 Sporulation related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000007532 239.0
TLS2_k127_394153_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K19696 - 2.4.2.44 0.000000000000000000000000000000000000000000000000000000003256 202.0
TLS2_k127_394153_2 Peptidoglycan-binding protein, CsiV - - - 0.0000000000000000000000000000007886 128.0
TLS2_k127_394153_3 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.000000000000000001237 87.0
TLS2_k127_3944940_0 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005554 455.0
TLS2_k127_3944940_1 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 310.0
TLS2_k127_3944940_2 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000000000007116 240.0
TLS2_k127_3944940_3 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000001922 212.0
TLS2_k127_3944940_4 converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA - - - 0.0000000002184 73.0
TLS2_k127_3950307_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 7.106e-287 904.0
TLS2_k127_3950307_1 FxsA cytoplasmic membrane protein - - - 0.000000000000000002271 100.0
TLS2_k127_399675_0 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002506 238.0
TLS2_k127_399675_1 Bacterial protein of unknown function (DUF883) - - - 0.0000000000000000000001864 104.0
TLS2_k127_399675_2 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000000000000000000183 99.0
TLS2_k127_399675_3 aminopeptidase activity - - - 0.0000000002685 68.0
TLS2_k127_399675_4 ATP-grasp domain - - - 0.00000006424 62.0
TLS2_k127_399868_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 5.081e-230 735.0
TLS2_k127_399868_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - 0.000000000000000000000000000000000000000000000001188 179.0
TLS2_k127_4005972_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 327.0
TLS2_k127_4005972_1 FAD binding domain K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000007004 262.0
TLS2_k127_4005972_2 MucB/RseB C-terminal domain - - - 0.00000000000000000000000000008641 123.0
TLS2_k127_4005972_3 Negative regulator of sigma E activity - - - 0.000000000000000009447 92.0
TLS2_k127_4040656_0 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000449 429.0
TLS2_k127_4040656_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 375.0
TLS2_k127_4040656_2 HI0933-like protein K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 304.0
TLS2_k127_4045068_0 Malic enzyme K00029 - 1.1.1.40 1.718e-281 874.0
TLS2_k127_4045068_1 Ribonuclease T2 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003673 251.0
TLS2_k127_4045068_2 Putative PepSY_TM-like K09939 - - 0.0000000000000000000000000000000000000000000968 180.0
TLS2_k127_4045068_3 PAS fold - - - 0.00000000000000000000001184 102.0
TLS2_k127_4049915_0 Aconitase C-terminal domain K01681 - 4.2.1.3 0.0 1440.0
TLS2_k127_4049915_1 Bacterial protein of unknown function (DUF839) - - - 2.142e-196 625.0
TLS2_k127_4049915_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004777 641.0
TLS2_k127_4049915_3 Anion-transporting ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 408.0
TLS2_k127_4049915_4 D-alanine [D-alanyl carrier protein] ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 323.0
TLS2_k127_4050764_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003833 518.0
TLS2_k127_4050764_1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006916 349.0
TLS2_k127_4050764_2 dna polymerase K02337 - 2.7.7.7 0.00000000000000000000000000000000004891 138.0
TLS2_k127_4059085_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006306 493.0
TLS2_k127_4059085_1 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 468.0
TLS2_k127_4059085_2 Glycerophosphoryl diester phosphodiesterase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 439.0
TLS2_k127_4059085_3 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000524 261.0
TLS2_k127_4059085_4 - - - - 0.000000000000000000000000000000000000000000000000000000001522 206.0
TLS2_k127_4059085_5 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates K01141 - 3.1.11.1 0.0000000000000000000000000000000186 128.0
TLS2_k127_4075189_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 1.113e-311 978.0
TLS2_k127_4075189_1 Succinylarginine dihydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 425.0
TLS2_k127_4075189_2 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005603 293.0
TLS2_k127_4075189_3 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000812 200.0
TLS2_k127_4075247_0 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000961 447.0
TLS2_k127_4075247_1 oxidoreductase activity, acting on CH-OH group of donors - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003144 396.0
TLS2_k127_4075247_10 SURF4 family - - - 0.00000000000000002315 82.0
TLS2_k127_4075247_2 Transcriptional regulator, LysR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006182 395.0
TLS2_k127_4075247_3 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001365 273.0
TLS2_k127_4075247_4 RNA polymerase sigma factor RpoH K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000525 261.0
TLS2_k127_4075247_5 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000007694 239.0
TLS2_k127_4075247_6 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.0000000000000000000000000000000000000000000000000002051 194.0
TLS2_k127_4075247_7 - - - - 0.00000000000000000000000000000000000000000000000002209 185.0
TLS2_k127_4075247_8 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000001599 179.0
TLS2_k127_4075247_9 - - - - 0.0000000000000000000004629 109.0
TLS2_k127_4089362_0 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K07712 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003432 594.0
TLS2_k127_4089362_1 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 478.0
TLS2_k127_4089362_2 PAP2 superfamily - - - 0.000000000000000000000000000000000000000000000006666 184.0
TLS2_k127_4089362_3 Domain of unknown function (DUF4124) - - - 0.00000000000000000000000000000004046 136.0
TLS2_k127_4093881_0 Nitrogen regulatory protein P-II - - - 0.00000000000000000000000000000000000000000000000000000000998 199.0
TLS2_k127_4093881_1 SMART zinc finger, CDGSH-type domain protein - - - 0.0000000000001843 78.0
TLS2_k127_4095563_0 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 320.0
TLS2_k127_4095563_1 flagellar protein FliS K02422 - - 0.00000000000000000000000000000007954 130.0
TLS2_k127_4095563_2 FlaG protein K06603 - - 0.0000000000001968 76.0
TLS2_k127_4096012_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 2.192e-216 677.0
TLS2_k127_4096012_1 Phosphoesterase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 484.0
TLS2_k127_4096012_2 Calcineurin-like phosphoesterase K14379 - 3.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 304.0
TLS2_k127_4151610_0 Protein of unknown function (DUF1329) - - - 1.203e-268 846.0
TLS2_k127_415748_0 pteridine-dependent deoxygenase K18240 - 4.1.3.40,4.1.3.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 338.0
TLS2_k127_415748_1 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000001833 248.0
TLS2_k127_415748_2 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000002331 218.0
TLS2_k127_415748_3 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000325 109.0
TLS2_k127_415748_4 amp-dependent synthetase and ligase - - - 0.0000000000000000000004685 99.0
TLS2_k127_417038_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1380.0
TLS2_k127_417038_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 3.268e-216 678.0
TLS2_k127_417038_2 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 354.0
TLS2_k127_417038_3 This protein specifically catalyzes the removal of signal peptides from prolipoproteins - - - 0.000000000000003514 76.0
TLS2_k127_4205409_0 Binding-protein-dependent transport system inner membrane component K02033,K15581 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 429.0
TLS2_k127_4205409_1 Binding-protein-dependent transport system inner membrane component K02034,K15582 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 361.0
TLS2_k127_4205409_2 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003325 241.0
TLS2_k127_4205409_3 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.000002738 50.0
TLS2_k127_4205446_0 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000563 261.0
TLS2_k127_4205446_1 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K13053 - - 0.000000000000000000000000000000000000000000000000001889 189.0
TLS2_k127_4205446_2 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000000009791 174.0
TLS2_k127_4205446_3 Protein of unknown function (DUF1631) - - - 0.0000000002393 73.0
TLS2_k127_421487_0 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000000000000000000001611 229.0
TLS2_k127_421487_1 Histidine phosphatase superfamily (branch 1) - - - 0.0000000000000000000000000000000000000000000000000000006841 198.0
TLS2_k127_421487_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11527 - 2.7.13.3 0.000001738 58.0
TLS2_k127_4236403_0 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 379.0
TLS2_k127_4236403_1 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000011 275.0
TLS2_k127_4236403_2 Thioredoxin-like - - - 0.0000000000000000002646 91.0
TLS2_k127_4240633_0 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 307.0
TLS2_k127_4240633_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000001284 107.0
TLS2_k127_4240633_2 Histidine kinase - - - 0.0000004006 56.0
TLS2_k127_4251039_0 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 589.0
TLS2_k127_4251039_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000008227 217.0
TLS2_k127_4251039_2 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000001112 203.0
TLS2_k127_4251039_3 YCII-related domain - - - 0.00000000000000000000000000000000000000000000184 172.0
TLS2_k127_4251039_4 PFAM YCII-related domain - - - 0.00000000000000000000000000000008615 130.0
TLS2_k127_4251039_5 Protein conserved in bacteria - - - 0.0000000000000000000000000000005583 122.0
TLS2_k127_4252580_0 MMPL family - - - 0.0 1352.0
TLS2_k127_4252580_1 Protein of unknown function (DUF1302) - - - 3.901e-264 833.0
TLS2_k127_4252580_2 Photosynthesis system II assembly factor YCF48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007365 316.0
TLS2_k127_4252580_3 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 289.0
TLS2_k127_4252580_4 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000007491 180.0
TLS2_k127_425771_0 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004469 490.0
TLS2_k127_425771_1 hemolysin III K11068 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 346.0
TLS2_k127_425771_2 Membrane protein implicated in regulation of membrane protease activity K07340 - - 0.00000000000000000000000000000000000000000000000005006 181.0
TLS2_k127_425771_3 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000002834 150.0
TLS2_k127_425771_4 hemolysin III K11068 - - 0.0000000000000000002438 90.0
TLS2_k127_425771_5 Protein of unknown function (DUF3106) - - - 0.0000000005413 68.0
TLS2_k127_425771_6 Esterase PHB depolymerase K03932 - - 0.00005876 49.0
TLS2_k127_4277940_0 FIST_C - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004962 499.0
TLS2_k127_4277940_1 - - - - 0.0000000000000000000000000000000000001828 145.0
TLS2_k127_4277940_2 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000002867 99.0
TLS2_k127_4281712_0 gtp-binding protein K06207 - - 0.0 1060.0
TLS2_k127_4281712_1 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 3.218e-240 759.0
TLS2_k127_4288283_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 1.067e-251 788.0
TLS2_k127_4288283_1 binding-protein-dependent transport systems inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000001589 184.0
TLS2_k127_4293965_0 phospholipase C K01114 - 3.1.4.3 5.149e-277 866.0
TLS2_k127_4320149_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 379.0
TLS2_k127_4325626_0 ABC-type multidrug transport system, ATPase component K13926 - - 0.0 1188.0
TLS2_k127_4325626_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion K01993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005246 467.0
TLS2_k127_4325626_2 Outer membrane drug efflux lipoprotein K18139 - - 0.00000000000000000000000000000000000000000000000000000001321 200.0
TLS2_k127_4346213_0 Major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 345.0
TLS2_k127_4346213_1 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004689 325.0
TLS2_k127_4346213_2 TIGRFAM acetoacetyl-CoA reductase K00023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000001939 232.0
TLS2_k127_4346213_3 - - - - 0.00000008698 55.0
TLS2_k127_4346213_4 - - - - 0.0000006466 52.0
TLS2_k127_4365943_0 Vacuole effluxer Atg22 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000492 513.0
TLS2_k127_4365943_1 Uracil DNA glycosylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008329 304.0
TLS2_k127_4365943_2 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000000000000000000000000000000000003128 168.0
TLS2_k127_4378209_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 1.88e-233 734.0
TLS2_k127_4378209_1 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000004103 243.0
TLS2_k127_4378209_2 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000834 217.0
TLS2_k127_4378209_3 Domain of unknown function (DUF1820) - - - 0.0000000000000000000000000000000000000000007682 159.0
TLS2_k127_4378209_4 Beta-lactamase superfamily domain - - - 0.0002316 45.0
TLS2_k127_4394582_0 FAD dependent oxidoreductase - - - 1.717e-312 964.0
TLS2_k127_4394582_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 8.981e-213 666.0
TLS2_k127_4394582_2 Cellulase (glycosyl hydrolase family 5) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006838 278.0
TLS2_k127_4394582_3 TonB-dependent Receptor Plug Domain K02014 - - 0.000000000000000000000000000000001644 132.0
TLS2_k127_440321_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 1.766e-315 974.0
TLS2_k127_440321_1 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 509.0
TLS2_k127_440321_2 succinate dehydrogenase - - - 0.0000000000000000000000000000000000000000009229 159.0
TLS2_k127_440321_3 Succinate dehydrogenase K00241 - - 0.000000000000000000000000000000000000006027 149.0
TLS2_k127_440321_4 - - - - 0.0000000000000000000000000001251 122.0
TLS2_k127_440321_5 Flavinator of succinate dehydrogenase K09159 - - 0.000000000000000000001925 96.0
TLS2_k127_440321_6 Belongs to the GcvT family K06980 - - 0.000000000000000002401 90.0
TLS2_k127_440321_7 Protein of unknown function (DUF1674) - - - 0.000000000562 63.0
TLS2_k127_4404995_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 518.0
TLS2_k127_4404995_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000002501 241.0
TLS2_k127_4404995_2 cell shape determination - - - 0.000000000000000000000000000000000000000000001287 172.0
TLS2_k127_4404995_3 membrane K08973 - - 0.00000000000000000000000000000000000002962 146.0
TLS2_k127_4411348_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 2.763e-311 966.0
TLS2_k127_4411348_1 - - - - 2.485e-204 645.0
TLS2_k127_4411348_2 Histidine kinase K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 576.0
TLS2_k127_4411348_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000005744 233.0
TLS2_k127_441715_0 penicillin-binding protein K05367 - 2.4.1.129 7.557e-284 890.0
TLS2_k127_441715_1 SMART Metal-dependent phosphohydrolase, HD region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 432.0
TLS2_k127_441715_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 302.0
TLS2_k127_441921_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 2.987e-196 618.0
TLS2_k127_441921_1 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 467.0
TLS2_k127_441921_2 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000001692 231.0
TLS2_k127_441921_3 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000000000000000003708 196.0
TLS2_k127_4427933_0 protein containing a von Willebrand factor type A (vWA) domain K07114 - - 6.353e-239 753.0
TLS2_k127_4427933_1 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009827 263.0
TLS2_k127_444877_0 Diguanylate cyclase K13069 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 445.0
TLS2_k127_444877_1 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 355.0
TLS2_k127_444877_2 Role in flagellar biosynthesis K02421 - - 0.0000000000000000000000000000000000000000000000000000000000000004504 229.0
TLS2_k127_446842_0 Neisseria PilC beta-propeller domain K02674 - - 4.596e-213 716.0
TLS2_k127_446842_1 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 527.0
TLS2_k127_446842_2 This protein specifically catalyzes the removal of signal peptides from prolipoproteins - - - 0.00000000000000000000000000000000000000204 149.0
TLS2_k127_446842_3 - - - - 0.0000000000000000000000000000000002567 139.0
TLS2_k127_446842_4 Type IV Pilus-assembly protein W - - - 0.000000000000000000003011 99.0
TLS2_k127_446842_5 Type IV minor pilin ComP, DNA uptake sequence receptor K02655 - - 0.0000000000000002554 85.0
TLS2_k127_4474161_0 aminotransferase K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 392.0
TLS2_k127_4474161_1 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 358.0
TLS2_k127_4474161_2 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004218 251.0
TLS2_k127_4474161_3 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000006365 198.0
TLS2_k127_4474161_4 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.00000000000000000000000000000000001185 138.0
TLS2_k127_4478379_0 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000001355 158.0
TLS2_k127_4478379_2 Membrane transport protein K07088 - - 0.0000000000000000000000009243 106.0
TLS2_k127_4493803_0 COG3459 Cellobiose phosphorylase - - - 0.0 2239.0
TLS2_k127_4493803_1 - - - - 0.000002675 49.0
TLS2_k127_4494141_0 Tetratricopeptide repeat - - - 4.733e-274 865.0
TLS2_k127_4502774_0 short-chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000377 310.0
TLS2_k127_4502774_1 Catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate K22292 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.105 0.00000000000000000000000003099 110.0
TLS2_k127_4502774_2 Sulfotransferase family - - - 0.0000000000000000000000002263 112.0
TLS2_k127_4505678_0 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 340.0
TLS2_k127_4505678_1 GspL periplasmic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 297.0
TLS2_k127_4505678_2 Type II secretion system protein K K02460 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002931 281.0
TLS2_k127_4505678_3 General secretion pathway protein K02456 - - 0.0000000000000000000000000000000000000000000000000000000000000005372 230.0
TLS2_k127_4505678_4 Type II secretion system (T2SS), protein J - - - 0.0000000000000000000000000000000000000000000000000000000000007421 221.0
TLS2_k127_4505678_5 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000001346 211.0
TLS2_k127_4505678_6 Type II secretion system (T2SS), protein I - - - 0.00000000000000000000000000000000000004608 147.0
TLS2_k127_4505678_7 Prokaryotic N-terminal methylation motif - - - 0.0000000000000000000000000000000204 139.0
TLS2_k127_4526744_0 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000004479 229.0
TLS2_k127_4526744_1 Beta-ketoacyl synthase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000004497 224.0
TLS2_k127_4526744_2 Belongs to the beta-ketoacyl-ACP synthases family K00647 - 2.3.1.41 0.000000000000000000000000000000000000000000000000004013 184.0
TLS2_k127_4526744_3 - - - - 0.0000000000000000000000000000000000000000007591 163.0
TLS2_k127_4526744_4 dehydratase - - - 0.000000000000000000000000009614 126.0
TLS2_k127_4534159_0 amine dehydrogenase activity - - - 8.233e-257 820.0
TLS2_k127_4534159_1 Belongs to the glycosyl hydrolase 31 family - - - 1.803e-248 791.0
TLS2_k127_4534159_10 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000000000000000000000008283 135.0
TLS2_k127_4534159_11 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000000158 138.0
TLS2_k127_4534159_12 Opacity family porin protein K03286 - - 0.000000000000000000005897 106.0
TLS2_k127_4534159_13 - - - - 0.0000000000000000002331 90.0
TLS2_k127_4534159_14 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000002815 100.0
TLS2_k127_4534159_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 562.0
TLS2_k127_4534159_3 Bacterial protein of unknown function (DUF839) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004326 474.0
TLS2_k127_4534159_4 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 388.0
TLS2_k127_4534159_5 Peptidase family S49 N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005013 386.0
TLS2_k127_4534159_6 Thrombospondin type 3 repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 317.0
TLS2_k127_4534159_7 phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001782 273.0
TLS2_k127_4534159_8 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000004122 243.0
TLS2_k127_4534159_9 EVE domain-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000006779 235.0
TLS2_k127_4539132_0 membrane K07278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003211 477.0
TLS2_k127_4539132_1 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 425.0
TLS2_k127_4539132_2 Family of uncharacterised function (DUF490) K09800 GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347 - 0.0004391 52.0
TLS2_k127_4558852_0 Dipeptidyl carboxypeptidase K01284 - 3.4.15.5 8.384e-304 952.0
TLS2_k127_4558852_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000001058 234.0
TLS2_k127_4558852_2 - - - - 0.000000000000000000000000000000000000004092 151.0
TLS2_k127_4558852_3 Phage derived protein Gp49-like (DUF891) - - - 0.0000000000000000000000000000000000002626 142.0
TLS2_k127_4589061_0 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 582.0
TLS2_k127_4589061_1 SbmA/BacA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 482.0
TLS2_k127_4589061_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000009066 186.0
TLS2_k127_4589797_0 Amidohydrolase family K06015 - 3.5.1.81 7.089e-319 983.0
TLS2_k127_4589797_1 - - - - 1.579e-268 845.0
TLS2_k127_4589797_2 Lipoprotein releasing system transmembrane protein K09808 - - 1.372e-214 671.0
TLS2_k127_4589797_3 Protein of unknown function (DUF1298) - - - 1.491e-195 619.0
TLS2_k127_4589797_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 520.0
TLS2_k127_4589797_5 Belongs to the ompA family K03286 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 443.0
TLS2_k127_4589797_6 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 335.0
TLS2_k127_4589797_7 Fatty acid hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006037 275.0
TLS2_k127_4589797_8 PFAM helix-turn-helix- domain containing protein, AraC type - - - 0.00000000000000000000000000000000000000000000000000000001382 211.0
TLS2_k127_4589797_9 Bacterial regulatory proteins, tetR family - - - 0.000000000000002141 86.0
TLS2_k127_4647500_0 highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues K01915 - 6.3.1.2 4.855e-288 887.0
TLS2_k127_4647500_1 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006566 594.0
TLS2_k127_4647500_2 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 532.0
TLS2_k127_4647500_3 Organic hydroperoxide resistance - - - 0.00000000000000000000000000000000000000000001823 165.0
TLS2_k127_4647500_4 membrane K09790 - - 0.000000000000000000000000000000000001478 151.0
TLS2_k127_4647500_5 psiF repeat - - - 0.00000002863 58.0
TLS2_k127_4663524_0 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005908 477.0
TLS2_k127_4663524_1 Phosphoadenylylsulfate reductase K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000005359 255.0
TLS2_k127_4663524_2 protein with SCP PR1 domains - - - 0.000000000000000000000000000000000001057 148.0
TLS2_k127_4663524_3 SlyX - - - 0.00000005012 58.0
TLS2_k127_4663524_4 Sortilin, neurotensin receptor 3, - - - 0.0006783 51.0
TLS2_k127_4685185_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003096 482.0
TLS2_k127_4685185_1 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 469.0
TLS2_k127_4685185_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000001102 230.0
TLS2_k127_4685185_3 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000139 81.0
TLS2_k127_4685492_0 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 585.0
TLS2_k127_4685492_1 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 426.0
TLS2_k127_4685492_2 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004891 375.0
TLS2_k127_4685492_3 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002042 271.0
TLS2_k127_4685492_4 Outer membrane lipoprotein-sorting protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000002086 244.0
TLS2_k127_4685492_5 membrane - - - 0.000000000000000000000000000000000008897 140.0
TLS2_k127_4685746_0 Haem-degrading - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 464.0
TLS2_k127_4702763_0 Cytidine and deoxycytidylate deaminase zinc-binding region - - - 0.0000000000000000000000000000000000000000000000000000000000026 214.0
TLS2_k127_4702763_2 Pfam Cupin - - - 0.000000000000000000238 88.0
TLS2_k127_4702763_3 Cytidine and deoxycytidylate deaminase zinc-binding region - - - 0.000601 43.0
TLS2_k127_471552_0 Cytochrome C biogenesis K02200 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004654 343.0
TLS2_k127_471552_1 Thiol disulfide interchange protein K02199 - - 0.0000000000000000000000000000000000000000000000000000000000000000007016 232.0
TLS2_k127_471552_2 subunit of a heme lyase K02200 - - 0.0000000000000000000000000000000000000000001298 164.0
TLS2_k127_471552_3 Cytochrome C biogenesis K02198 - - 0.0000000000000000000000000000000000037 139.0
TLS2_k127_471552_4 Outer membrane lipoprotein Slp K07285 - - 0.000000000000000000000001604 110.0
TLS2_k127_4737952_0 salt-induced outer membrane protein K07283 - - 0.000000000000000000000000000000000000000000000000000000231 201.0
TLS2_k127_4737952_1 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000006749 197.0
TLS2_k127_4737952_2 Ferredoxin - - - 0.000000000000000000000000000000000000000000000005428 173.0
TLS2_k127_4737952_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K18298,K18901 - - 0.0000000000000000000003931 101.0
TLS2_k127_4752609_0 Penicillin amidase - - - 8.845e-297 931.0
TLS2_k127_4752609_1 NADH ubiquinone oxidoreductase subunit K00342 - 1.6.5.3 3.23e-232 728.0
TLS2_k127_4752609_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000533 541.0
TLS2_k127_4752609_3 Sugar kinase K00856 - 2.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 344.0
TLS2_k127_4752609_4 Protein of unknown function, DUF547 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008097 284.0
TLS2_k127_4752609_5 NADH ubiquinone oxidoreductase subunit K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000003257 200.0
TLS2_k127_4753395_0 Hydantoinase/oxoprolinase N-terminal region - - - 2.908e-269 844.0
TLS2_k127_4753395_1 Hydantoinase/oxoprolinase N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 603.0
TLS2_k127_4753395_2 MMPL family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007507 268.0
TLS2_k127_4753395_3 Acetone carboxylase gamma subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001169 268.0
TLS2_k127_4753395_4 Steryl acetyl hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000002941 240.0
TLS2_k127_4754442_0 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 9.732e-280 863.0
TLS2_k127_4754442_1 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 419.0
TLS2_k127_4754442_2 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K03184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003364 415.0
TLS2_k127_4754442_3 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 358.0
TLS2_k127_4754442_4 COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 328.0
TLS2_k127_4754442_5 Thioredoxin K03672 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000001067 239.0
TLS2_k127_4754442_6 IG-like fold at C-terminal of FixG, putative oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000003553 226.0
TLS2_k127_4754442_7 Cbb3-type cytochrome oxidase component FixQ - - - 0.000000000004254 67.0
TLS2_k127_4765654_0 Type II secretory pathway K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 599.0
TLS2_k127_4765654_1 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006753 370.0
TLS2_k127_4765654_2 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 304.0
TLS2_k127_4765654_3 Cell division protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001273 245.0
TLS2_k127_4765654_4 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000001522 238.0
TLS2_k127_4765654_5 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.00000000000000000000000000000000000000000000000000000000000000465 235.0
TLS2_k127_4765654_6 DNA gyrase inhibitor YacG - - - 0.000000000000000004894 91.0
TLS2_k127_4778832_0 Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 1.298e-251 788.0
TLS2_k127_4778832_1 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003904 605.0
TLS2_k127_4778832_2 Histidine kinase K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007416 424.0
TLS2_k127_4778832_3 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001376 273.0
TLS2_k127_4778832_4 Cytidylyltransferase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003504 246.0
TLS2_k127_4778832_5 Cell division protein - - - 0.000000000000002797 85.0
TLS2_k127_4778832_6 Glycosyltransferase family 25 (LPS biosynthesis protein) K07270 - - 0.00000006319 64.0
TLS2_k127_4778832_7 - K06950 - - 0.0002535 50.0
TLS2_k127_4795957_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007431 360.0
TLS2_k127_4795957_1 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006146 332.0
TLS2_k127_4795957_2 Response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000001263 192.0
TLS2_k127_4796929_0 NADH-quinone oxidoreductase K00336 - 1.6.5.3 1.126e-207 651.0
TLS2_k127_4796929_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 314.0
TLS2_k127_4798594_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 5.44e-233 732.0
TLS2_k127_4798594_1 Belongs to the SUA5 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009786 328.0
TLS2_k127_4798594_2 Intracellular septation protein A - - - 0.00000000000000000000000000000000000000000000000000000000000000001356 230.0
TLS2_k127_4798594_3 YCII-related domain K09780 - - 0.00000000000000000000000000001801 120.0
TLS2_k127_4798594_4 Belongs to the BolA IbaG family K05527 - - 0.0000000000000000000000003347 113.0
TLS2_k127_4810339_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0 1058.0
TLS2_k127_4810339_1 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 422.0
TLS2_k127_4810339_2 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000856 409.0
TLS2_k127_4810339_3 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 411.0
TLS2_k127_4810339_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000626 365.0
TLS2_k127_4810339_5 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005776 333.0
TLS2_k127_4810339_6 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 305.0
TLS2_k127_4810339_7 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002978 257.0
TLS2_k127_4810339_8 Belongs to the CDS family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000000000000000000000000000000009049 257.0
TLS2_k127_4818453_0 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 529.0
TLS2_k127_4818453_1 PFAM ABC transporter related K01990,K13926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 326.0
TLS2_k127_4818453_2 Helicase c2 K10844 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000006828 229.0
TLS2_k127_4830070_0 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.0 1075.0
TLS2_k127_4830070_1 Protein of unknown function (DUF1329) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 595.0
TLS2_k127_4830070_2 Protein of unknown function (DUF1329) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006917 571.0
TLS2_k127_4830070_3 peptidylprolyl K03772 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006297 338.0
TLS2_k127_4830070_4 Belongs to the MtfA family K09933 - - 0.0000000000000000000000000000000000000000000000000000000000000000003908 236.0
TLS2_k127_4830070_5 Domain of unknown function (DUF4112) - - - 0.00000000000000000000000000000202 124.0
TLS2_k127_4890425_0 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005114 336.0
TLS2_k127_4890425_1 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 291.0
TLS2_k127_4890425_2 Lysin motif - - - 0.000000000000000000000000000000000000000000000005114 179.0
TLS2_k127_4897269_0 Histidine ammonia-lyase K01745 - 4.3.1.3 1.3e-233 730.0
TLS2_k127_4897269_1 deiminase K05603 - 3.5.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 408.0
TLS2_k127_4900454_0 Angiotensin-converting enzyme K01283 - 3.4.15.1 2.801e-314 978.0
TLS2_k127_4900454_1 GGDEF domain - - - 1.441e-241 791.0
TLS2_k127_4900454_2 Transporter K03305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006086 584.0
TLS2_k127_4910780_0 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009419 255.0
TLS2_k127_4910780_1 Histidine kinase K07778 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000009708 257.0
TLS2_k127_4910780_2 OmpW family - - - 0.000000000000000000000000000000000000000000000005921 179.0
TLS2_k127_4910780_3 Domain of unknown function (DUF5122) beta-propeller - - - 0.0000000000001404 82.0
TLS2_k127_4910780_4 PFAM TPR repeat-containing protein - - - 0.00000002854 62.0
TLS2_k127_4912215_0 PrkA AAA domain K07180 - - 0.0 1154.0
TLS2_k127_4912215_1 Protein of unknown function (DUF444) K09786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004874 595.0
TLS2_k127_4912215_2 SpoVR like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000062 515.0
TLS2_k127_4913375_0 Fatty acid desaturase K00496 - 1.14.15.3 3.191e-208 652.0
TLS2_k127_4913375_1 Oxidoreductase FAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004134 460.0
TLS2_k127_4913375_11 DDE domain - - - 0.000001426 51.0
TLS2_k127_4913375_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 391.0
TLS2_k127_4913375_3 Domain of unknown function (DUF4010) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006842 389.0
TLS2_k127_4913375_4 DDE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 367.0
TLS2_k127_4913375_5 GCN5 family acetyltransferase K09181 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000963 349.0
TLS2_k127_4913375_7 MafB19-like deaminase K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001638 250.0
TLS2_k127_4913375_8 PFAM Cupin 2 conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000002318 193.0
TLS2_k127_4913375_9 - - - - 0.0000000000000000000000006286 111.0
TLS2_k127_492939_0 cyclic-guanylate-specific phosphodiesterase activity K21025 - - 9.238e-231 736.0
TLS2_k127_492939_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 398.0
TLS2_k127_492939_2 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 395.0
TLS2_k127_4956098_0 N-acyl-L-amino acid amidohydrolase K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004285 497.0
TLS2_k127_4956098_1 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005509 358.0
TLS2_k127_4956098_2 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005555 332.0
TLS2_k127_4964413_0 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 315.0
TLS2_k127_4964413_1 Phosphoribosyl-ATP pyrophosphohydrolase - - - 0.000000000000000000000000000000000001561 140.0
TLS2_k127_4964413_2 XRE family transcriptional regulator - - - 0.00000000000000000000000000000001694 128.0
TLS2_k127_4964413_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.0000000000000000000000000001806 117.0
TLS2_k127_4964413_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000000000000001417 95.0
TLS2_k127_4964413_5 Dioxygenase - - - 0.0007936 44.0
TLS2_k127_4977086_0 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000814 533.0
TLS2_k127_4977086_1 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009513 496.0
TLS2_k127_4977086_10 STAS domain - - - 0.000000000003755 75.0
TLS2_k127_4977086_2 abc transporter atp-binding protein K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004759 417.0
TLS2_k127_4977086_3 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 335.0
TLS2_k127_4977086_4 murein transglycosylase K08305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 334.0
TLS2_k127_4977086_5 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 304.0
TLS2_k127_4977086_6 Lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002998 265.0
TLS2_k127_4977086_7 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000000000001173 226.0
TLS2_k127_4977086_8 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000000000000000000000000000000000000000000000000000003028 205.0
TLS2_k127_4977086_9 ABC-type transport system involved in resistance to organic solvents auxiliary component K07323 - - 0.00000000000000000000000000000000000000000000000000005038 193.0
TLS2_k127_498440_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02298 - 1.10.3.10 0.0 1186.0
TLS2_k127_498440_1 Histidine kinase K15011 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004911 557.0
TLS2_k127_498440_2 cytochrome o ubiquinol oxidase subunit III K02299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007758 344.0
TLS2_k127_498440_3 SURF1 family K14998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 314.0
TLS2_k127_498440_4 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain K15012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002795 268.0
TLS2_k127_498440_5 Prokaryotic Cytochrome C oxidase subunit IV K02300 - - 0.00000000000000000000000000000000000000000000125 178.0
TLS2_k127_498440_6 ubiquinol oxidase subunit K02297 - 1.10.3.10 0.0000000000000000000000000000000000000008353 150.0
TLS2_k127_498440_7 Phosphoesterase family - - - 0.0000000000000000304 81.0
TLS2_k127_498456_0 Type II secretory pathway, component HofQ K02666 - - 4.655e-275 867.0
TLS2_k127_498456_1 synthase K00574 - 2.1.1.79 7.864e-213 667.0
TLS2_k127_498456_11 assembly protein (PilN) K02663 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003889 243.0
TLS2_k127_498456_12 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate K07566 GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000008383 236.0
TLS2_k127_498456_13 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000000000000000000000000000000000000000000009142 232.0
TLS2_k127_498456_14 pilus assembly protein pilp K02665 - - 0.00000000000000000000000000000000000000000000000000000003854 204.0
TLS2_k127_498456_15 ACT domain K09707 - - 0.00000000000000000000000000000000000001868 148.0
TLS2_k127_498456_16 Protein of unknown function (DUF1475) - - - 0.000000000000000000000000000001665 130.0
TLS2_k127_498456_17 dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0015949,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.000000000000000000000000000008007 134.0
TLS2_k127_498456_2 NAD FAD-binding protein K06954 - - 1.612e-204 644.0
TLS2_k127_498456_3 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002688 542.0
TLS2_k127_498456_4 Pilus assembly protein K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005707 518.0
TLS2_k127_498456_5 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009678 471.0
TLS2_k127_498456_6 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009489 454.0
TLS2_k127_498456_7 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 402.0
TLS2_k127_498456_8 Protein of unknown function (DUF1365) K09701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 314.0
TLS2_k127_498456_9 Pilus assembly protein, PilO K02664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007265 282.0
TLS2_k127_498760_0 Belongs to the FBPase class 1 family K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007312 570.0
TLS2_k127_498760_1 porphyrin biosynthesis protein K02498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 404.0
TLS2_k127_498760_2 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 308.0
TLS2_k127_498760_3 enzyme of heme biosynthesis K02496,K13543 - 2.1.1.107,4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000001454 265.0
TLS2_k127_498760_4 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.00000000000000000000000000000000000000000000001047 176.0
TLS2_k127_498760_5 mRNA catabolic process - - - 0.000000000000000000000000000000000000000000005372 166.0
TLS2_k127_498760_6 YoeB-like toxin of bacterial type II toxin-antitoxin system - - - 0.000000000000000000000000000000000000007911 149.0
TLS2_k127_498760_7 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000000000000000000001459 131.0
TLS2_k127_498760_8 Uroporphyrinogen-III synthase K01719 - 4.2.1.75 0.0000000007545 60.0
TLS2_k127_498786_0 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002213 285.0
TLS2_k127_498786_1 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.000000000000000000000000000000000000000000000000000001256 195.0
TLS2_k127_498786_2 Protein of unknown function (DUF2834) - - - 0.000000000000000000000003274 105.0
TLS2_k127_4997588_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1407.0
TLS2_k127_4997588_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000003798 211.0
TLS2_k127_4997588_2 cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000002535 151.0
TLS2_k127_4997588_3 transcriptional regulator K01420 - - 0.00000000000000000000000000000000000279 147.0
TLS2_k127_4997602_0 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000759 392.0
TLS2_k127_5022970_0 Domain of unknown function (DUF3336) - - - 1.497e-209 661.0
TLS2_k127_5022970_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 1.129e-208 656.0
TLS2_k127_5022970_2 twitching motility protein K02670 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004043 508.0
TLS2_k127_5024687_0 glutamate dehydrogenase K15371 - 1.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 581.0
TLS2_k127_5024687_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000008881 239.0
TLS2_k127_5024687_2 Belongs to the CinA family K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000119 193.0
TLS2_k127_5027708_0 Cysteine desulfurase activator complex subunit SufB K09014 - - 6.24e-198 621.0
TLS2_k127_5027708_1 Uncharacterised protein family (UPF0227) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001355 269.0
TLS2_k127_5027708_2 Acyl-ACP thioesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000007043 232.0
TLS2_k127_5027708_3 transcriptional regulator - - - 0.00000000000000000000000000000000000000000001538 168.0
TLS2_k127_5027708_4 Protein of unknown function (DUF3293) - - - 0.000000000000000000000000000000003941 133.0
TLS2_k127_5027708_5 - - - - 0.00000000000000000001993 94.0
TLS2_k127_5027708_7 NAD(P)H-dependent FMN reductase K19784 - - 0.00002283 49.0
TLS2_k127_5031130_0 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006386 367.0
TLS2_k127_5031130_1 SET domain K07117 - - 0.0000000000000000000000000000000000000000000000000000000004913 206.0
TLS2_k127_5031130_2 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000009118 201.0
TLS2_k127_5031130_3 RF-1 domain K15034 - - 0.000000000000000000000000000000000000005271 151.0
TLS2_k127_5031130_4 COG1278 Cold shock proteins K03704 - - 0.00000000000000000000000000000002356 127.0
TLS2_k127_5031130_5 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00002703 46.0
TLS2_k127_5039760_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 596.0
TLS2_k127_5039760_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009754 284.0
TLS2_k127_5039760_2 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000006222 261.0
TLS2_k127_5053788_0 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 5.054e-229 721.0
TLS2_k127_5053788_1 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000568 150.0
TLS2_k127_5053788_2 Bacterial regulatory proteins, tetR family - - - 0.0002896 45.0
TLS2_k127_5056711_0 FAD binding domain - - - 1.089e-270 848.0
TLS2_k127_5056711_1 Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds K04073 - 1.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004191 502.0
TLS2_k127_5056711_2 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 461.0
TLS2_k127_5056711_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 422.0
TLS2_k127_5056711_4 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 386.0
TLS2_k127_5063214_0 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003435 270.0
TLS2_k127_5063214_1 cheY-homologous receiver domain K02485 - - 0.000000000000000000000000000000000000000000000000000004056 196.0
TLS2_k127_5063214_2 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.00000000000000000000000000001621 132.0
TLS2_k127_5073506_0 Amino acid kinase family - - - 9.467e-194 614.0
TLS2_k127_5073506_1 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005571 586.0
TLS2_k127_5073506_10 Belongs to the UPF0149 family K09895 - - 0.00000000000000000000000000000000000008971 147.0
TLS2_k127_5073506_11 receptor K16090 - - 0.0000000000000000000005511 95.0
TLS2_k127_5073506_2 PRTRC system protein D - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 505.0
TLS2_k127_5073506_3 PFAM FMN-dependent alpha-hydroxy acid dehydrogenase K00101,K16422 - 1.1.2.3,1.1.3.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009242 486.0
TLS2_k127_5073506_4 Biopolymer K03561 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002535 404.0
TLS2_k127_5073506_5 PKHD-type hydroxylase K07336 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 334.0
TLS2_k127_5073506_6 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 301.0
TLS2_k127_5073506_7 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000000004611 274.0
TLS2_k127_5073506_8 Biopolymer K03559 - - 0.000000000000000000000000000000000000000000000000000001229 201.0
TLS2_k127_5073506_9 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000000000000000000000000000000000000002472 167.0
TLS2_k127_5087427_0 PhoD-like phosphatase K01113 - 3.1.3.1 9.035e-290 899.0
TLS2_k127_5087427_1 L-lysine 6-monooxygenase (NADPH-requiring) - - - 2.037e-202 642.0
TLS2_k127_5087427_2 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004297 301.0
TLS2_k127_5087427_3 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000003519 215.0
TLS2_k127_5095165_0 E3 component of 2-oxoglutarate dehydrogenase complex K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009852 596.0
TLS2_k127_5095165_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 479.0
TLS2_k127_5095165_2 E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate K00164 - 1.2.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 412.0
TLS2_k127_5095165_3 Gram-negative porin - - - 0.0000000000000000000000000000000000000004777 168.0
TLS2_k127_510059_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000473 581.0
TLS2_k127_510059_1 Multidrug resistance efflux pump K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 361.0
TLS2_k127_510059_2 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000003145 235.0
TLS2_k127_510059_3 Thioesterase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000169 209.0
TLS2_k127_510059_4 Transcriptional regulator K18301 - - 0.0000000000000000000000000000000000000000000000000000101 197.0
TLS2_k127_5120294_0 Acyclic terpene utilisation family protein AtuA - - - 7.652e-221 689.0
TLS2_k127_5120294_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 576.0
TLS2_k127_5120294_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 371.0
TLS2_k127_5120294_3 Asp/Glu/Hydantoin racemase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 347.0
TLS2_k127_5120294_4 Riboflavin synthase K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000001123 247.0
TLS2_k127_5120294_5 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000003101 240.0
TLS2_k127_5120294_6 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000000000000000000000000000000000003535 224.0
TLS2_k127_5120294_7 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000000000000000000000000000000000000001985 201.0
TLS2_k127_5127381_0 Cellulose synthase catalytic subunit (UDP-forming) K00694 - 2.4.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009321 554.0
TLS2_k127_5127381_1 Belongs to the glycosyl hydrolase 8 (cellulase D) family K01179,K20542 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 410.0
TLS2_k127_5127381_2 Cellulose synthase operon protein C C-terminus (BCSC_C) K20543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 339.0
TLS2_k127_5130170_0 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001441 256.0
TLS2_k127_5130170_1 Protein of unknown function (DUF3014) - - - 0.00000000000000000000000000000000000000000000000000000000000004023 224.0
TLS2_k127_5130170_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000002005 128.0
TLS2_k127_5132714_0 MacB-like periplasmic core domain - - - 2.19e-197 622.0
TLS2_k127_5132714_1 TIGRFAM type I secretion outer membrane protein, TolC family K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 451.0
TLS2_k127_5132714_2 Outer membrane drug efflux lipoprotein K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 349.0
TLS2_k127_5132714_3 - - - - 0.0000000000000000000000000000000004935 146.0
TLS2_k127_516388_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 602.0
TLS2_k127_516388_1 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 291.0
TLS2_k127_5174691_0 phospholipase C K01114 - 3.1.4.3 9.367e-261 816.0
TLS2_k127_5174691_1 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001964 276.0
TLS2_k127_5174691_2 Ethanolamine ammonia-lyase K03735 - 4.3.1.7 0.0000000000000000000000000000000009934 131.0
TLS2_k127_5211835_0 PQQ-like domain - - - 0.0 1128.0
TLS2_k127_5211835_1 Ser Thr phosphatase family protein K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007616 474.0
TLS2_k127_5211835_2 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.0000000000005222 69.0
TLS2_k127_5257832_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002372 260.0
TLS2_k127_5257832_1 Universal stress protein family - - - 0.0000000000000000000000000000000000000000005548 169.0
TLS2_k127_5273903_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 6.059e-219 684.0
TLS2_k127_5273903_1 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 608.0
TLS2_k127_5273903_2 Phosphoglycerate mutase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002041 293.0
TLS2_k127_5273903_3 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000008397 158.0
TLS2_k127_5273903_4 Transcriptional regulator - - - 0.000005769 48.0
TLS2_k127_5274881_0 membrane - - - 9.285e-280 881.0
TLS2_k127_5281579_0 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 388.0
TLS2_k127_5281579_1 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000000000000000000002785 198.0
TLS2_k127_5281579_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.00000000000000000000000000000000000000000000000006973 184.0
TLS2_k127_5285431_0 type I site-specific restriction-modification system, R subunit K01153 - 3.1.21.3 0.0 1278.0
TLS2_k127_5285431_1 stress-induced protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 290.0
TLS2_k127_5320850_0 hydrolase of the alpha beta-hydrolase fold K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 359.0
TLS2_k127_5320850_1 YCII-related domain - - - 0.000000000000000000000000000000000000000000005083 165.0
TLS2_k127_5320850_2 Metal-dependent hydrolase K07044 - - 0.00000000000000000000000000004063 119.0
TLS2_k127_5320850_3 5'-nucleotidase K01081 - 3.1.3.5 0.0000000000000005317 77.0
TLS2_k127_5324302_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009407 378.0
TLS2_k127_5324302_1 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000005105 109.0
TLS2_k127_5324302_2 Mo-molybdopterin cofactor metabolic process K03636 - - 0.00003411 56.0
TLS2_k127_5355420_0 LVIVD repeat - - - 0.0 1530.0
TLS2_k127_5355420_1 Domain of unknown function (DUF4331) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002066 238.0
TLS2_k127_5356003_0 STELLO glycosyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006175 324.0
TLS2_k127_5356003_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000001053 210.0
TLS2_k127_5356003_2 Acyltransferase family - - - 0.0000000000000000008628 100.0
TLS2_k127_5356003_3 Glycosyl transferases group 1 - - - 0.000000000003081 69.0
TLS2_k127_540266_0 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000008939 246.0
TLS2_k127_540266_1 the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000001775 205.0
TLS2_k127_540266_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000005376 146.0
TLS2_k127_5419421_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 2.84e-200 629.0
TLS2_k127_5419421_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 612.0
TLS2_k127_5419421_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 533.0
TLS2_k127_5419421_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004334 391.0
TLS2_k127_542373_0 Catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 575.0
TLS2_k127_542373_1 Belongs to the pseudouridine synthase RsuA family K06178 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 332.0
TLS2_k127_542373_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002903 315.0
TLS2_k127_542373_3 Peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001071 263.0
TLS2_k127_542373_4 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009853 263.0
TLS2_k127_5434477_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 346.0
TLS2_k127_5434477_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 355.0
TLS2_k127_5434477_2 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000004054 173.0
TLS2_k127_5434477_3 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000000000000000000000001242 138.0
TLS2_k127_5434477_4 Putative phosphatase (DUF442) - - - 0.0000000000000000000000001034 118.0
TLS2_k127_5434477_5 mRNA 3'-end processing factor K07577 - - 0.000000000000000005991 84.0
TLS2_k127_5448390_0 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 459.0
TLS2_k127_5448390_1 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000000000000000001758 230.0
TLS2_k127_5448390_2 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000001003 191.0
TLS2_k127_5448390_3 transcriptional regulators K03892 - - 0.0000000000000000000000000000000000004252 143.0
TLS2_k127_5448390_4 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.000000000000000000000009416 108.0
TLS2_k127_5448390_5 acetyltransferase - - - 0.00000000000000000000002972 102.0
TLS2_k127_5472489_0 Saccharopine dehydrogenase NADP binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006995 535.0
TLS2_k127_5472489_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008752 428.0
TLS2_k127_5472489_2 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002408 254.0
TLS2_k127_5472489_3 small membrane protein - - - 0.0000000000000000000000000000000000000000004004 169.0
TLS2_k127_5472489_4 Protein of unknown function (DUF1499) - - - 0.00000000000000000000007406 101.0
TLS2_k127_5485986_0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 578.0
TLS2_k127_5485986_1 alpha beta - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 473.0
TLS2_k127_5485986_2 Two component response regulator for the phosphate regulon K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006837 408.0
TLS2_k127_5485986_3 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000005655 127.0
TLS2_k127_5506464_0 type II secretion system protein E K02454,K02652 - - 8.554e-217 698.0
TLS2_k127_5506464_1 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 497.0
TLS2_k127_5506464_2 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008473 351.0
TLS2_k127_5506464_3 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.0000000000000000000000000000000000000000000000000001769 201.0
TLS2_k127_5506464_4 ABC-type phosphate transport system, periplasmic component - - - 0.00000000000000000000000000000004508 130.0
TLS2_k127_5514454_0 Acetolactate synthase K01652 - 2.2.1.6 3.611e-311 962.0
TLS2_k127_5514454_1 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000394 317.0
TLS2_k127_5514454_2 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000003291 167.0
TLS2_k127_5514454_3 Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - 0.000000000000000000000000006725 119.0
TLS2_k127_5521119_0 Transfers a succinyl group from succinyl-CoA to L- serine, forming succinyl-L-serine K00641 - 2.3.1.31 1.908e-202 644.0
TLS2_k127_5521119_1 YGGT family - - - 0.00000000000000000000000000000000000000000000000000000000000000002468 228.0
TLS2_k127_5521119_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000008835 100.0
TLS2_k127_5539613_0 Belongs to the GPI family - - - 4.043e-221 698.0
TLS2_k127_5539613_1 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 566.0
TLS2_k127_5539613_10 Deoxynucleoside kinase - - - 0.00000000000000000000000000000000000000000000000000000002625 210.0
TLS2_k127_5539613_11 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000000000000000006017 167.0
TLS2_k127_5539613_12 DNA polymerase III chi subunit, HolC - - - 0.000000000000000000000000000000000000000211 154.0
TLS2_k127_5539613_13 RDD family - - - 0.00000000000000000000000003328 114.0
TLS2_k127_5539613_14 - - - - 0.00000000000002255 79.0
TLS2_k127_5539613_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 555.0
TLS2_k127_5539613_3 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 535.0
TLS2_k127_5539613_4 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 445.0
TLS2_k127_5539613_5 overlaps another CDS with the same product name K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 347.0
TLS2_k127_5539613_6 Putative 2OG-Fe(II) oxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008486 303.0
TLS2_k127_5539613_7 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009296 301.0
TLS2_k127_5539613_8 Sulfite exporter TauE/SafE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006267 278.0
TLS2_k127_5539613_9 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.000000000000000000000000000000000000000000000000000000000000173 214.0
TLS2_k127_5546284_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 6.171e-292 912.0
TLS2_k127_5546284_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007597 316.0
TLS2_k127_5546284_2 Helicase K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005531 299.0
TLS2_k127_5557502_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1169.0
TLS2_k127_5557502_1 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 4.277e-250 807.0
TLS2_k127_5557502_10 - - - - 0.00000000000000000000000005211 111.0
TLS2_k127_5557502_11 GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000009972 83.0
TLS2_k127_5557502_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 6.315e-234 728.0
TLS2_k127_5557502_3 Acyltransferase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 547.0
TLS2_k127_5557502_4 Belongs to the agmatine deiminase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 510.0
TLS2_k127_5557502_5 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008786 415.0
TLS2_k127_5557502_6 Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis K03683 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 323.0
TLS2_k127_5557502_7 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003399 285.0
TLS2_k127_5557502_8 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000003333 254.0
TLS2_k127_5557502_9 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000003934 230.0
TLS2_k127_5574130_0 D-glucuronyl C5-epimerase C-terminus K01793 GO:0000139,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0006022,GO:0006023,GO:0006024,GO:0006029,GO:0006082,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0015012,GO:0015015,GO:0016020,GO:0016853,GO:0016854,GO:0016857,GO:0019538,GO:0030166,GO:0030201,GO:0030202,GO:0030203,GO:0030210,GO:0030334,GO:0031090,GO:0031984,GO:0032879,GO:0034645,GO:0040008,GO:0040012,GO:0040014,GO:0040018,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045927,GO:0046983,GO:0047464,GO:0048518,GO:0048638,GO:0048639,GO:0050379,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051239,GO:0051240,GO:0051270,GO:0065007,GO:0071704,GO:0098588,GO:0098791,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903510,GO:2000145 5.1.3.17 0.00000000000000000000000000000000001099 143.0
TLS2_k127_5578956_0 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 0.0 1012.0
TLS2_k127_5578956_1 Steryl acetyl hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 443.0
TLS2_k127_5578956_2 Protein of unknown function (DUF1697) - - - 0.00000000000000000000000000000000000000000000000000000000000000000121 236.0
TLS2_k127_5578956_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000001617 165.0
TLS2_k127_5578956_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000003542 113.0
TLS2_k127_5578956_5 PFAM glutathione-dependent formaldehyde-activating GFA - - - 0.00000001691 59.0
TLS2_k127_5578956_6 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0001108 53.0
TLS2_k127_5591186_0 Cytochrome P450 - - - 6.281e-221 694.0
TLS2_k127_5591186_1 Amidohydrolase - - - 3.205e-220 686.0
TLS2_k127_5591186_2 Rieske [2Fe-2S] domain - - - 3.356e-194 610.0
TLS2_k127_5591186_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000142 193.0
TLS2_k127_5591186_4 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.00000000000000000000000000000000000000000000000000002484 196.0
TLS2_k127_5591186_5 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000007383 179.0
TLS2_k127_5592333_0 secretion system protein K02283,K20527 - - 1.408e-197 621.0
TLS2_k127_5592333_1 Belongs to the GSP D family K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 457.0
TLS2_k127_5592333_2 COG4963 Flp pilus assembly protein, ATPase CpaE K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 404.0
TLS2_k127_5592333_3 Flp pilus assembly protein RcpC/CpaB - - - 0.00000000000000000000000000000000000000000000000000000000000000000001909 239.0
TLS2_k127_5597474_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 2.971e-272 855.0
TLS2_k127_5597474_1 TIGRFAM Cell shape determining protein MreB Mrl K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 501.0
TLS2_k127_5597474_2 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 421.0
TLS2_k127_5597474_3 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005744 325.0
TLS2_k127_5597474_4 Glu-tRNAGln amidotransferase C subunit - - - 0.000000000000000000000000000000000007754 138.0
TLS2_k127_5597474_5 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 - - 0.00000000000000000000000000004811 129.0
TLS2_k127_5600418_0 D-isomer specific 2-hydroxyacid dehydrogenase K03778 - 1.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006543 462.0
TLS2_k127_5600418_1 Metal-dependent hydrolase K07043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000615 243.0
TLS2_k127_5600418_2 Mechanosensitive ion channel - - - 0.000000000000000000000001903 107.0
TLS2_k127_5600418_3 - - - - 0.00000000000000000000007355 109.0
TLS2_k127_5600418_4 S4 domain K14761 - - 0.000000000000000000000249 100.0
TLS2_k127_5612935_0 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008546 473.0
TLS2_k127_5612935_1 dehydratase K08678 - 4.1.1.35 0.00000000000000000000000000000000000000000000000001056 182.0
TLS2_k127_5617325_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 1.871e-208 662.0
TLS2_k127_5617325_1 homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009672 432.0
TLS2_k127_5620440_0 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 349.0
TLS2_k127_5620440_1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 342.0
TLS2_k127_5620440_3 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000000000000000000001136 213.0
TLS2_k127_5630983_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 0.0 1142.0
TLS2_k127_5630983_1 Phosphate starvation protein PhoH K07175 - - 3.347e-256 796.0
TLS2_k127_5630983_10 Recombinase zinc beta ribbon domain K06400 - - 0.000002453 53.0
TLS2_k127_5630983_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 410.0
TLS2_k127_5630983_3 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 339.0
TLS2_k127_5630983_4 ACT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000507 317.0
TLS2_k127_5630983_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 320.0
TLS2_k127_5630983_6 Peroxiredoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000334 252.0
TLS2_k127_5630983_7 - - - - 0.0000000000000000000000000000000000000001197 153.0
TLS2_k127_5630983_8 Molecular chaperone. Has ATPase activity K04079 - - 0.00000000000000000001062 92.0
TLS2_k127_5630983_9 helix_turn_helix, mercury resistance K19591 - - 0.0000000000000000006181 90.0
TLS2_k127_5667470_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006807 490.0
TLS2_k127_5667470_1 Peptidase M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004121 286.0
TLS2_k127_5667470_2 Rhodanese-related sulfurtransferase - - - 0.00000000000000000000000000000000000001378 147.0
TLS2_k127_5697307_0 Peptidase family M13 K07386 - - 6.528e-226 720.0
TLS2_k127_5697307_1 Peptidase family M13 K07386 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 589.0
TLS2_k127_5697307_2 Thioesterase-like superfamily - - - 0.00000000000000000000000000000001175 135.0
TLS2_k127_5700893_0 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000779 278.0
TLS2_k127_5700893_1 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000007044 231.0
TLS2_k127_5700893_2 CYTH domain protein K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000004961 218.0
TLS2_k127_5700893_3 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000002528 176.0
TLS2_k127_5712290_0 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 603.0
TLS2_k127_5712290_1 Crp-like helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 344.0
TLS2_k127_5712290_2 Domain of unknown function (DUF4398) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 321.0
TLS2_k127_5712290_3 Crp-like helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000001698 213.0
TLS2_k127_5712290_4 COG2230 Cyclopropane fatty acid synthase and related methyltransferases K00574 - 2.1.1.79 0.000000000000000000000000000000000000003091 158.0
TLS2_k127_5712290_5 CsbD-like - - - 0.000000000000000000000000001433 113.0
TLS2_k127_5712290_6 Domain of unknown function (DUF4398) - - - 0.000000000000000000000000001587 117.0
TLS2_k127_5712290_7 CsbD-like - - - 0.000000000000171 78.0
TLS2_k127_5719221_0 PhoD-like phosphatase, N-terminal domain K01113 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 509.0
TLS2_k127_5719221_1 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 470.0
TLS2_k127_5719221_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004788 290.0
TLS2_k127_5719221_3 COG NOG14600 non supervised orthologous group - - - 0.00000000000000000000000000000000000000000000000001001 181.0
TLS2_k127_5719221_4 Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000001195 141.0
TLS2_k127_5719221_6 COG NOG14600 non supervised orthologous group - - - 0.00006046 46.0
TLS2_k127_5730116_0 acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 497.0
TLS2_k127_5730116_1 Proline racemase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 328.0
TLS2_k127_5730116_2 depolymerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001971 290.0
TLS2_k127_5730116_3 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000005696 183.0
TLS2_k127_5730116_4 - - - - 0.000000000000000000000002086 105.0
TLS2_k127_5733944_0 4Fe-4S dicluster domain - - - 0.0 1041.0
TLS2_k127_5733944_1 - - - - 0.00000000000000000000000000000000000000000000000003684 205.0
TLS2_k127_5753065_0 Polyketide synthase dehydratase - - - 0.0 1759.0
TLS2_k127_5753065_1 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 465.0
TLS2_k127_5753065_3 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000005554 168.0
TLS2_k127_5754658_0 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease K03694 - - 0.0 1064.0
TLS2_k127_5754658_1 phosphomannomutase K15778 - 5.4.2.2,5.4.2.8 1.694e-222 706.0
TLS2_k127_5754658_10 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000000000000000000000000000000000000000000000003184 248.0
TLS2_k127_5754658_11 Protein of unknown function (DUF1134) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002641 246.0
TLS2_k127_5754658_2 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 611.0
TLS2_k127_5754658_3 Reduces the stability of FtsZ polymers in the presence of ATP K06916 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 474.0
TLS2_k127_5754658_4 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 325.0
TLS2_k127_5754658_5 Glycosyl transferase family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000839 331.0
TLS2_k127_5754658_6 recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 319.0
TLS2_k127_5754658_7 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 302.0
TLS2_k127_5754658_8 D-arabinono-1,4-lactone oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 307.0
TLS2_k127_5754658_9 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006644 264.0
TLS2_k127_5757507_0 5'-nucleotidase, C-terminal domain - - - 1.092e-219 696.0
TLS2_k127_5757507_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 463.0
TLS2_k127_5757507_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 338.0
TLS2_k127_5757507_3 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001508 278.0
TLS2_k127_5757507_4 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000000000004843 189.0
TLS2_k127_5757507_5 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000000000002132 156.0
TLS2_k127_5757507_6 - - - - 0.0000000000000003127 86.0
TLS2_k127_5785236_0 AAA domain K02450 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 565.0
TLS2_k127_5785236_1 ABC-3 protein K02075 - - 0.00000000000000000000000000000000000000000000000000000000000000000002206 241.0
TLS2_k127_5785236_2 Type II secretion system protein B - - - 0.00000000000000000000009266 110.0
TLS2_k127_5785236_3 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.0000000000000000006596 87.0
TLS2_k127_578821_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 6.785e-209 662.0
TLS2_k127_578821_1 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002175 279.0
TLS2_k127_5790079_0 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003118 416.0
TLS2_k127_5790079_1 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.00000000000000000000000000000000000000000000000004325 183.0
TLS2_k127_5790079_2 domain, Protein - - - 0.0000000001841 72.0
TLS2_k127_5798730_0 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 416.0
TLS2_k127_5798730_1 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 325.0
TLS2_k127_5798730_2 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 293.0
TLS2_k127_5798730_3 TPM domain K06872 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001488 279.0
TLS2_k127_5798730_4 TPM domain - - - 0.000000000000000000000000000000000000000000000000000000000003209 214.0
TLS2_k127_5798730_5 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.0000000000000000000000000000000000000001614 155.0
TLS2_k127_5816705_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0 1399.0
TLS2_k127_5816705_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 5.487e-220 703.0
TLS2_k127_5816705_10 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.00000000000000000000000000000000000000000000000000407 197.0
TLS2_k127_5816705_2 ArgJ family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003669 555.0
TLS2_k127_5816705_3 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 551.0
TLS2_k127_5816705_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008081 516.0
TLS2_k127_5816705_5 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 437.0
TLS2_k127_5816705_6 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 436.0
TLS2_k127_5816705_7 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 428.0
TLS2_k127_5816705_8 Membrane proteins related to metalloendopeptidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 335.0
TLS2_k127_5816705_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003556 280.0
TLS2_k127_5835330_0 COG3459 Cellobiose phosphorylase - - - 0.0 1887.0
TLS2_k127_5835330_1 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 292.0
TLS2_k127_5835330_2 - - - - 0.0000000000000000005066 91.0
TLS2_k127_5876087_0 abc transporter atp-binding protein - - - 5.776e-321 998.0
TLS2_k127_5876087_1 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005565 430.0
TLS2_k127_5876087_2 Protein of unknown function (DUF815) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 342.0
TLS2_k127_5876087_3 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 345.0
TLS2_k127_5876087_4 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000001476 73.0
TLS2_k127_5876087_5 Domain of unknown function (DUF4124) - - - 0.0007059 49.0
TLS2_k127_5890020_0 twitching motility protein - - - 3.279e-201 632.0
TLS2_k127_5890020_1 twitching motility protein K02669 - - 2.023e-196 630.0
TLS2_k127_5890020_10 - - - - 0.00000001819 63.0
TLS2_k127_5890020_2 twitching motility protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 558.0
TLS2_k127_5890020_3 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 315.0
TLS2_k127_5890020_4 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 303.0
TLS2_k127_5890020_5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000003453 246.0
TLS2_k127_5890020_6 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000001463 223.0
TLS2_k127_5890020_7 Domain of unknown function (DUF4399) - - - 0.00000000000000000000000000000000000000000000000000000000001281 210.0
TLS2_k127_5890020_8 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000306 151.0
TLS2_k127_5890020_9 - - - - 0.0000000000408 63.0
TLS2_k127_5922377_0 AMP-binding enzyme - - - 1.453e-261 818.0
TLS2_k127_5922377_1 negative regulation of translational initiation - - - 0.00000000000000000000000000000000000000000000000000001107 196.0
TLS2_k127_5922377_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000004776 89.0
TLS2_k127_592257_0 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008744 469.0
TLS2_k127_592257_1 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000158 228.0
TLS2_k127_592257_2 Pilus assembly protein PilZ K02676 - - 0.0000000000000000000000000000000000000000000000000000000000004674 213.0
TLS2_k127_592257_3 NlpC/P60 family - - - 0.00000000000000000000000000000000000001768 148.0
TLS2_k127_592257_4 the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA K02341 - 2.7.7.7 0.000001307 54.0
TLS2_k127_593770_0 Phospholipase D Active site motif K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005854 533.0
TLS2_k127_593770_1 Ketopantoate reductase PanE/ApbA C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000331 257.0
TLS2_k127_5956051_0 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 366.0
TLS2_k127_5956051_1 peptide ABC transporter substrate-binding protein K07165 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009143 277.0
TLS2_k127_5956051_2 Putative serine dehydratase domain K01753 - 4.3.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000002578 270.0
TLS2_k127_5956051_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000003893 226.0
TLS2_k127_5959653_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 493.0
TLS2_k127_5959653_1 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 350.0
TLS2_k127_5959653_2 Competence protein CoiA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000003671 239.0
TLS2_k127_5959653_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000544 222.0
TLS2_k127_5959653_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000003433 202.0
TLS2_k127_5959653_5 Phosphoribulokinase / Uridine kinase family - - - 0.0000000000000000756 82.0
TLS2_k127_5966334_0 AcrB/AcrD/AcrF family K15726 - - 0.0 1368.0
TLS2_k127_5966334_1 cellulase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 323.0
TLS2_k127_5966334_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007231 291.0
TLS2_k127_5966334_3 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000005411 186.0
TLS2_k127_5966334_4 Crp-like helix-turn-helix domain - - - 0.000000000000008051 76.0
TLS2_k127_5986582_0 PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000423 384.0
TLS2_k127_5986582_1 Cation efflux family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004039 264.0
TLS2_k127_5986582_2 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000000000008789 201.0
TLS2_k127_5986582_3 Protein of unknown function (DUF421) - - - 0.00000000000000002355 84.0
TLS2_k127_5988919_0 PUA-like domain K00958 - 2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 405.0
TLS2_k127_5988919_1 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K15396 - 2.1.1.200 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 338.0
TLS2_k127_5988919_2 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005946 297.0
TLS2_k127_5988919_3 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000001395 157.0
TLS2_k127_6001793_0 dna polymerase K02337 - 2.7.7.7 0.0 1388.0
TLS2_k127_6001793_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000222 262.0
TLS2_k127_6001793_2 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000003845 210.0
TLS2_k127_6006799_0 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 372.0
TLS2_k127_6006799_1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007106 251.0
TLS2_k127_6006799_2 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000002035 218.0
TLS2_k127_6006799_3 OmpA family - - - 0.0000000000000001322 80.0
TLS2_k127_6006799_4 carboxylase - - - 0.0000000000000001727 79.0
TLS2_k127_6009835_0 PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 444.0
TLS2_k127_6009835_1 Response regulator containing a CheY-like receiver domain and an HD-GYP domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000009473 219.0
TLS2_k127_6020782_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1566.0
TLS2_k127_6020782_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 5.927e-310 957.0
TLS2_k127_6020782_2 aminotransferase K00812 - 2.6.1.1 2.087e-201 632.0
TLS2_k127_6020782_3 Heat shock protein K04046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 578.0
TLS2_k127_6020782_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 370.0
TLS2_k127_6035197_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.337e-294 914.0
TLS2_k127_6035197_1 PFAM AMP-dependent synthetase and ligase K20034 - 6.2.1.44 9.085e-234 734.0
TLS2_k127_6035197_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 4.167e-214 673.0
TLS2_k127_6035197_3 Belongs to the KdsA family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005424 488.0
TLS2_k127_6035197_4 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000007725 64.0
TLS2_k127_6048926_0 Glutaryl-7-ACA acylase - - - 4.61e-226 719.0
TLS2_k127_6048926_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0000000001863 61.0
TLS2_k127_6064326_0 Chemotaxis protein histidine kinase and related kinases K02487,K06596 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009316 606.0
TLS2_k127_6064326_1 response regulator K02657 - - 0.00000000000000000000000000000000000000000000000000000000000003364 220.0
TLS2_k127_6064326_2 Two component signalling adaptor domain K02659 - - 0.0000000000000000000000000000000000000000000000000000000000006191 215.0
TLS2_k127_6109686_0 ADP-glyceromanno-heptose 6-epimerase activity - - - 8.82e-205 649.0
TLS2_k127_6109686_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 539.0
TLS2_k127_6117215_0 Flavin containing amine oxidoreductase - - - 4.548e-206 650.0
TLS2_k127_6117215_1 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 289.0
TLS2_k127_6117215_2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002528 270.0
TLS2_k127_6117215_3 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005226 254.0
TLS2_k127_6117215_4 Protein of unknown function (DUF3108) - - - 0.0000000000000000000000000000000000000000000000008097 183.0
TLS2_k127_6117215_5 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000001409 129.0
TLS2_k127_6123355_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000001589 237.0
TLS2_k127_6123355_1 Fatty acid hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000003862 214.0
TLS2_k127_6123355_2 Anti-sigma-K factor rskA - - - 0.00000000000000000000000000001042 132.0
TLS2_k127_6123355_3 phospholipase C K01114 - 3.1.4.3 0.0000000000000003431 79.0
TLS2_k127_6132025_0 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000418 436.0
TLS2_k127_6132025_1 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001136 277.0
TLS2_k127_6132025_2 - - - - 0.00000000000000009756 88.0
TLS2_k127_6141191_0 AcrB/AcrD/AcrF family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006994 568.0
TLS2_k127_6141191_1 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004882 542.0
TLS2_k127_6141191_2 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 306.0
TLS2_k127_6141191_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001383 298.0
TLS2_k127_6141191_4 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000004199 248.0
TLS2_k127_6141191_5 Protein of unknown function (DUF541) - - - 0.000000000000000000000000000000000000000000000000000000000000000009674 234.0
TLS2_k127_6141191_6 - - - - 0.000000000000000000000000000000000000000000000000000000000008555 218.0
TLS2_k127_6160294_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 5.048e-298 925.0
TLS2_k127_6160294_1 X-Pro dipeptidyl-peptidase (S15 family) - - - 1.514e-231 735.0
TLS2_k127_6160294_2 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008477 382.0
TLS2_k127_6160294_3 abc transporter atp-binding protein K06158 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003667 316.0
TLS2_k127_6160974_0 Neisseria PilC beta-propeller domain K02674 - - 0.0 1266.0
TLS2_k127_6160974_1 Prepilin-type cleavage methylation-like K02672 - - 0.000000000000000000000000000000000000000000000000000000000000005646 231.0
TLS2_k127_6160974_2 - - - - 0.0000000000000000000000002369 114.0
TLS2_k127_6160974_3 - - - - 0.000000000000004712 79.0
TLS2_k127_6164149_0 methyltransferase - - - 0.000000000000000000000000000000000000000000000000005116 190.0
TLS2_k127_6164149_1 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000003374 185.0
TLS2_k127_6181279_0 Polyketide synthase dehydratase - - - 6.866e-218 692.0
TLS2_k127_6181279_1 Polyketide synthase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006419 357.0
TLS2_k127_6181430_0 permease K07089 - - 6.263e-237 739.0
TLS2_k127_6181430_1 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 0.000000000000000000000000000000000000000000000000000000000000004407 222.0
TLS2_k127_6181430_2 Thioredoxin domain - - - 0.00000000000000000000000000000006393 126.0
TLS2_k127_6181430_3 F5/8 type C domain - - - 0.0000000000000000000000006636 108.0
TLS2_k127_6186760_0 acetolactate synthase K01652 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 536.0
TLS2_k127_6226715_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II K01835 - 5.4.2.2 1.317e-256 801.0
TLS2_k127_6226715_1 Elongation factor P--(R)-beta-lysine ligase K04568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 436.0
TLS2_k127_6226715_2 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression K06204 - - 0.00000000000000000000000000000000000000000000000000000000000007013 221.0
TLS2_k127_6226715_3 Protein of unknown function (DUF1249) K09920 - - 0.0000000000000000000000000000000000000000000000000000000001546 210.0
TLS2_k127_6226715_4 YceI-like domain - - - 0.0000000000000000000000000000000000000000000000000000000008605 210.0
TLS2_k127_6226715_5 Protein of unknown function (DUF1302) - - - 0.0000000000000000000000000000000000000000000000000000001101 198.0
TLS2_k127_6226715_6 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 GO:0002943,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000003088 94.0
TLS2_k127_6271345_0 Threonine dehydratase K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003482 577.0
TLS2_k127_6271345_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006945 559.0
TLS2_k127_6271345_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000001661 106.0
TLS2_k127_6274966_0 Small-conductance mechanosensitive channel K05802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 340.0
TLS2_k127_6274966_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000007225 120.0
TLS2_k127_6294299_0 polysaccharide catabolic process K07407 - 3.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005498 453.0
TLS2_k127_6294299_1 Neutral/alkaline non-lysosomal ceramidase, C-terminal - - - 0.000000000000000000000000000000000000000002427 157.0
TLS2_k127_6310100_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 2.52e-258 799.0
TLS2_k127_6310100_1 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 493.0
TLS2_k127_6310100_2 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008979 463.0
TLS2_k127_6310100_3 PFAM AraC-type transcriptional regulator N-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 348.0
TLS2_k127_6310100_4 mRNA catabolic process - - - 0.00000000000000000000000000000000000000000000000000000000001327 223.0
TLS2_k127_6310100_5 PFAM ribosomal protein L31 K02909 - - 0.00000000000000000000000009683 113.0
TLS2_k127_6310100_6 Cysteine-rich CPXCG - - - 0.0000000000000000002502 88.0
TLS2_k127_6310100_7 Antibiotic biosynthesis monooxygenase - - - 0.000000000005895 72.0
TLS2_k127_6314513_0 Urease alpha-subunit, N-terminal domain K01428 - 3.5.1.5 1.507e-306 943.0
TLS2_k127_6314513_1 receptor - - - 9.132e-209 677.0
TLS2_k127_6314513_10 COG0760 Parvulin-like peptidyl-prolyl isomerase - - - 0.00000000000000000000000000000000000000000000000000000000001618 222.0
TLS2_k127_6314513_11 Biopolymer transport protein ExbD/TolR - - - 0.00000000000000000000000000000000000000000000000000000001782 202.0
TLS2_k127_6314513_12 Urease, gamma subunit K01430 - 3.5.1.5 0.000000000000000000000000000000000000000000000000003112 182.0
TLS2_k127_6314513_13 Urease beta subunit K01429 - 3.5.1.5 0.0000000000000000000000000000000000000000001665 162.0
TLS2_k127_6314513_2 Arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003723 614.0
TLS2_k127_6314513_3 Belongs to the arginase family K01476,K01480 - 3.5.3.1,3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 574.0
TLS2_k127_6314513_4 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 544.0
TLS2_k127_6314513_5 Belongs to the arginase family K01476,K01480 - 3.5.3.1,3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 497.0
TLS2_k127_6314513_6 MotA/TolQ/ExbB proton channel family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005632 368.0
TLS2_k127_6314513_7 UreD urease accessory protein K03190 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 349.0
TLS2_k127_6314513_8 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006409 281.0
TLS2_k127_6314513_9 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000006213 235.0
TLS2_k127_6334988_0 Part of the ABC transporter complex cysAWTP involved in sulfate thiosulfate import K02047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 471.0
TLS2_k127_6334988_1 ABC-type sulfate transport system permease component K02046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 423.0
TLS2_k127_6334988_2 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008652 306.0
TLS2_k127_6334988_3 transporter component K07112 - - 0.00000000000000000000000000000000000001144 156.0
TLS2_k127_6334988_4 transporter component K07112 - - 0.000000000000000000000000000000000009045 141.0
TLS2_k127_6354773_0 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006559 436.0
TLS2_k127_6354773_1 Catalyzes a key regulatory step in fatty acid biosynthesis K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009672 417.0
TLS2_k127_6354773_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000000000000000000000000000000000000000000000009342 184.0
TLS2_k127_6354773_3 peptidylprolyl isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000104 148.0
TLS2_k127_6373838_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 430.0
TLS2_k127_6373838_1 Phosphatidylserine decarboxylase K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006445 307.0
TLS2_k127_6373838_2 SCO1/SenC K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003795 245.0
TLS2_k127_6373838_3 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.298 0.0000000000000000000000000000000000000000000000000000000000000002575 236.0
TLS2_k127_6373838_4 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000003159 222.0
TLS2_k127_6389124_0 chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 434.0
TLS2_k127_6389124_1 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005402 326.0
TLS2_k127_6389124_2 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.0000000000000000000000000000000000000000000000000000000002809 207.0
TLS2_k127_6395201_1 PFAM SMP-30 Gluconolaconase - - - 0.0000002464 62.0
TLS2_k127_6408042_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1207.0
TLS2_k127_6408042_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 443.0
TLS2_k127_6408042_2 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 359.0
TLS2_k127_6408042_3 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002667 276.0
TLS2_k127_6410982_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 1.065e-300 924.0
TLS2_k127_6410982_1 Belongs to the glucose-6-phosphate 1-epimerase family K01792 - 5.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 304.0
TLS2_k127_6410982_2 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000004213 265.0
TLS2_k127_6410982_3 Protein of unknown function (DUF465) K09794 - - 0.000000000000000000000006737 104.0
TLS2_k127_6424788_0 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 7.554e-233 727.0
TLS2_k127_6424788_1 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 400.0
TLS2_k127_6424788_2 Response regulator of the LytR AlgR family K08083 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 367.0
TLS2_k127_643355_0 DNA recombination protein, rmuC K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000583 460.0
TLS2_k127_643355_1 Protein of unknown function (DUF3641) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002349 272.0
TLS2_k127_644541_0 Cytochrome C biogenesis K02198 - - 3.218e-255 799.0
TLS2_k127_644541_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000357 463.0
TLS2_k127_644541_10 PFAM YcfA-like protein K07339 - - 0.00000000000000000000002922 100.0
TLS2_k127_644541_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 427.0
TLS2_k127_644541_3 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 386.0
TLS2_k127_644541_4 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006148 252.0
TLS2_k127_644541_5 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000000000000000000004826 213.0
TLS2_k127_644541_6 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000000000000000000000000001908 207.0
TLS2_k127_644541_7 TIGRFAM Addiction module toxin, Txe YoeB K19158 - - 0.000000000000000000000000000000000000000336 151.0
TLS2_k127_644541_8 Antitoxin component of a toxin-antitoxin (TA) module K19159 - - 0.0000000000000000000000000005549 115.0
TLS2_k127_644541_9 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000000000005365 105.0
TLS2_k127_6446755_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 2.525e-301 930.0
TLS2_k127_6446755_1 X-Pro dipeptidyl-peptidase (S15 family) - - - 6.524e-260 840.0
TLS2_k127_6446755_2 PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 448.0
TLS2_k127_6446755_3 MatE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003611 372.0
TLS2_k127_6446755_4 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 383.0
TLS2_k127_6446755_5 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000073 174.0
TLS2_k127_6446755_6 Outer Membrane Lipoprotein K06077 - - 0.0000000000000000000000000000000542 134.0
TLS2_k127_6446755_7 PFAM major facilitator superfamily MFS_1 K16139 - - 0.00000000000000005651 94.0
TLS2_k127_6446755_8 Bacterial regulatory proteins, tetR family - - - 0.00000000002162 73.0
TLS2_k127_6454257_0 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 562.0
TLS2_k127_6454257_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007988 345.0
TLS2_k127_6460959_0 Flagellar hook protein FlgE K02390 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005204 483.0
TLS2_k127_6460959_1 Belongs to the flagella basal body rod proteins family K02396 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 349.0
TLS2_k127_6460959_2 Belongs to the flagella basal body rod proteins family K02391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000225 263.0
TLS2_k127_6460959_3 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.0000000000000000000000000000000000000000000000001553 184.0
TLS2_k127_6460959_4 Belongs to the flagella basal body rod proteins family K02388 - - 0.00000000000000000000000000000000000000000009279 166.0
TLS2_k127_6460959_5 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.000000000000000001025 87.0
TLS2_k127_6467386_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 7.392e-228 709.0
TLS2_k127_6467386_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 593.0
TLS2_k127_6467386_2 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 568.0
TLS2_k127_6467386_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 489.0
TLS2_k127_6467386_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 369.0
TLS2_k127_6467386_5 Tfp pilus assembly protein FimV K08086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 393.0
TLS2_k127_6467386_6 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 360.0
TLS2_k127_6467386_7 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000002857 275.0
TLS2_k127_6467386_8 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000003625 201.0
TLS2_k127_6467386_9 Belongs to the folylpolyglutamate synthase family K11754 GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 0.00007302 46.0
TLS2_k127_6473064_0 domain protein - - - 2.447e-199 636.0
TLS2_k127_6473064_1 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 458.0
TLS2_k127_6473064_2 OmpA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009875 417.0
TLS2_k127_6478736_0 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 477.0
TLS2_k127_6478736_1 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 325.0
TLS2_k127_6478736_2 Thioesterase superfamily K07107 - - 0.000000000000000000000000000000000000000000007763 169.0
TLS2_k127_6478736_3 Outer membrane lipoprotein carrier protein LolA - - - 0.00000000000000000000000000000000000007769 151.0
TLS2_k127_6478736_4 Glycosyl transferase family 2 - - - 0.00000000000000000000134 94.0
TLS2_k127_6478736_5 COG0644 Dehydrogenases (flavoproteins) - - - 0.0000000001693 61.0
TLS2_k127_6485419_0 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 340.0
TLS2_k127_6485419_1 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 319.0
TLS2_k127_6485419_2 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004864 304.0
TLS2_k127_6485419_3 - - - - 0.00000000000000000000000001927 117.0
TLS2_k127_6487721_0 Signal transduction histidine kinase K07637 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007455 386.0
TLS2_k127_6487721_1 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006734 259.0
TLS2_k127_6487721_2 Cystathionine beta-synthase K01697 - 4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000007207 241.0
TLS2_k127_6517356_0 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 441.0
TLS2_k127_6517356_1 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002333 279.0
TLS2_k127_6517356_2 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001499 255.0
TLS2_k127_6517356_3 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000004523 194.0
TLS2_k127_6517356_4 cell adhesion - - - 0.000000000000000000000000001658 116.0
TLS2_k127_6517356_5 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0000000000000002124 91.0
TLS2_k127_6517356_6 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.00003024 47.0
TLS2_k127_6517583_0 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 437.0
TLS2_k127_6517583_1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - - 0.000000000000000000000000000000000000000000000000000000000000000000001387 244.0
TLS2_k127_6517583_2 BON domain - - - 0.0000000000000000000000001675 113.0
TLS2_k127_6520792_0 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009189 517.0
TLS2_k127_6520792_1 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009003 340.0
TLS2_k127_6520792_2 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000009425 268.0
TLS2_k127_6520792_3 Membrane - - - 0.0000000000000000000000000000000000001311 152.0
TLS2_k127_6520792_4 CBS domain - - - 0.0000000000000000000000000000000003678 136.0
TLS2_k127_6520792_5 Belongs to the HSP15 family K04762 - - 0.000000000000000000000000000002514 127.0
TLS2_k127_6560628_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 8.968e-204 642.0
TLS2_k127_6560628_1 dna polymerase III delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 338.0
TLS2_k127_6560628_2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000000000000000003465 238.0
TLS2_k127_6574905_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004177 593.0
TLS2_k127_6574905_1 Histidyl-tRNA synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 568.0
TLS2_k127_6574905_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 - 0.0000000000000000000000000000000000000000000000000000000000000000218 229.0
TLS2_k127_6574905_3 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000009892 243.0
TLS2_k127_6574905_4 protein conserved in bacteria K15539 - - 0.0000000000000000000000001146 109.0
TLS2_k127_6575413_0 basal body rod K02392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 390.0
TLS2_k127_6575413_1 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004119 259.0
TLS2_k127_6575413_2 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.00000000000000000000000000000000000000000000000000000000000001346 223.0
TLS2_k127_6577898_0 Bacterial virulence factor lipase N-terminal - - - 8.541e-228 728.0
TLS2_k127_6577898_1 Protein of unknown function (DUF1302) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003772 596.0
TLS2_k127_6577898_2 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 412.0
TLS2_k127_6577898_3 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000001386 179.0
TLS2_k127_6592026_0 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 7.482e-199 643.0
TLS2_k127_6592026_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 359.0
TLS2_k127_6592026_2 Periplasmic binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006159 343.0
TLS2_k127_6592026_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000003195 126.0
TLS2_k127_6592026_4 MraZ protein, putative antitoxin-like K03925 - - 0.0000000000000000000000000001005 120.0
TLS2_k127_6592026_5 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000008752 96.0
TLS2_k127_6592026_6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.00000000000000001962 88.0
TLS2_k127_6592026_8 - - - - 0.00000000001762 75.0
TLS2_k127_6603494_0 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 612.0
TLS2_k127_6603494_1 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001347 280.0
TLS2_k127_6610339_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003845 512.0
TLS2_k127_6610339_1 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000007081 258.0
TLS2_k127_6610339_2 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000005605 236.0
TLS2_k127_6620797_0 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007784 488.0
TLS2_k127_6620797_1 Branched-chain amino acid ATP-binding cassette transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 438.0
TLS2_k127_6620797_2 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 346.0
TLS2_k127_6620797_3 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 344.0
TLS2_k127_6634882_0 Protein of unknown function (DUF1302) - - - 0.0 1052.0
TLS2_k127_6634882_1 Protein of unknown function (DUF1302) - - - 7.154e-293 922.0
TLS2_k127_6634882_2 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 1.849e-244 758.0
TLS2_k127_6634882_3 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 354.0
TLS2_k127_6634882_4 cytochrome K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 295.0
TLS2_k127_6634882_5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001656 278.0
TLS2_k127_6634882_6 stringent starvation protein b K03600 - - 0.00000000000000000000000000000000000000000000000000000003886 199.0
TLS2_k127_6634882_7 stringent starvation protein A K03599 - - 0.00000000000000000000000000000000000000000000000002335 186.0
TLS2_k127_6634882_8 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000003436 141.0
TLS2_k127_6653586_0 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003466 473.0
TLS2_k127_6653586_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 363.0
TLS2_k127_6663473_0 Aldehyde dehydrogenase family - - - 3.289e-232 727.0
TLS2_k127_6663473_1 Protein of unknown function (DUF1329) - - - 7.072e-211 657.0
TLS2_k127_6663473_2 Fungal family of unknown function (DUF1776) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 464.0
TLS2_k127_6663473_3 Catalyzes the synthesis of activated sulfate K00860,K00958 - 2.7.1.25,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007116 330.0
TLS2_k127_6676033_0 Cellulose synthase catalytic subunit (UDP-forming) K00694 - 2.4.1.12 0.0 1352.0
TLS2_k127_6676033_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00322 - 1.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 605.0
TLS2_k127_6676033_2 cystathionine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 586.0
TLS2_k127_6676033_3 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 450.0
TLS2_k127_6676033_4 Uncharacterised protein, DegV family COG1307 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000092 380.0
TLS2_k127_6676033_5 cellulose synthase operon protein YhjQ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000003403 237.0
TLS2_k127_6676033_6 DNA mismatch repair protein MutT - - - 0.0000000000000000000000000000000000000000000000000000000001401 211.0
TLS2_k127_6676033_7 Cellulose synthase subunit D - - - 0.0000000000000000000000000000000000000000000897 165.0
TLS2_k127_6678405_0 AMP-binding enzyme - - - 1.793e-226 714.0
TLS2_k127_6678405_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001774 268.0
TLS2_k127_6689864_0 Divalent cation transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 449.0
TLS2_k127_6689864_1 Sulfite exporter TauE/SafE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 300.0
TLS2_k127_6689864_2 pathogenesis - - - 0.000000000000000000000000000000000000000000000000009488 191.0
TLS2_k127_6689864_3 Thioesterase superfamily - - - 0.000000000000000000000000000000000002817 152.0
TLS2_k127_6689864_4 membrane - - - 0.000000000000001028 83.0
TLS2_k127_6690702_0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 519.0
TLS2_k127_6690702_1 Phosphate K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 325.0
TLS2_k127_6690702_2 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 308.0
TLS2_k127_6690702_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000001338 174.0
TLS2_k127_6690702_4 thiamine biosynthesis protein ThiS K03154 - - 0.00000000000002995 76.0
TLS2_k127_6690702_5 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000001012 66.0
TLS2_k127_6691654_0 Flavin-binding monooxygenase-like - - - 3.325e-288 891.0
TLS2_k127_6691654_1 COG2207 AraC-type DNA-binding domain-containing proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 475.0
TLS2_k127_6691654_2 fatty acid desaturase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008658 458.0
TLS2_k127_6691654_3 transcriptional regulator - - - 0.000000000000000000000000000000000000000001724 162.0
TLS2_k127_6708043_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1009.0
TLS2_k127_6708043_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 3.178e-279 866.0
TLS2_k127_6708043_2 Membrane - - - 0.00000000000000000000003872 106.0
TLS2_k127_6708043_3 Histidine kinase - - - 0.00002798 48.0
TLS2_k127_6719481_0 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 3.57e-231 726.0
TLS2_k127_6719481_1 type II secretion system protein K02454 - - 9.992e-209 664.0
TLS2_k127_6719481_2 PrcB C-terminal - - - 0.000000000000000003774 93.0
TLS2_k127_6719481_3 Acyltransferase - - - 0.000000000000001616 78.0
TLS2_k127_6724173_0 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008333 514.0
TLS2_k127_6724173_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000002031 187.0
TLS2_k127_6724543_0 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 440.0
TLS2_k127_6724543_1 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005978 274.0
TLS2_k127_6724543_2 serine-type peptidase activity - - - 0.0000000000000000000000000000000002478 145.0
TLS2_k127_6724543_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000003824 52.0
TLS2_k127_6727585_0 Peptidase family M3 K01414 - 3.4.24.70 1.664e-280 874.0
TLS2_k127_6727585_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.27e-237 746.0
TLS2_k127_6727585_2 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 563.0
TLS2_k127_6727585_3 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005183 298.0
TLS2_k127_6727585_4 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000000000000001245 196.0
TLS2_k127_6727585_5 nucleotidase K01082 - 3.1.3.7 0.00000000000000000000000000000009126 133.0
TLS2_k127_6727585_6 H-NS histone family K03746 - - 0.00000000000001122 78.0
TLS2_k127_6738656_0 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 549.0
TLS2_k127_6738656_1 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.000000000000000000000002546 104.0
TLS2_k127_6738656_2 sensor protein - - - 0.0000000001058 75.0
TLS2_k127_6748901_0 Thiol disulfide Interchange Protein K04084 - 1.8.1.8 3.437e-223 715.0
TLS2_k127_6748901_1 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 531.0
TLS2_k127_6748901_2 Protein of unknown function (DUF2845) - - - 0.0000000000000000000000000000000000000000000003289 177.0
TLS2_k127_6784104_0 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001039 263.0
TLS2_k127_6784104_1 - - - - 0.00000000000000000000000000000000000000000000000000000000008779 209.0
TLS2_k127_6784104_2 Lysin motif - - - 0.00000000001109 71.0
TLS2_k127_6786036_0 Sugar transferases involved in lipopolysaccharide synthesis K03606,K13656,K20997 - 2.7.8.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003003 497.0
TLS2_k127_6786036_1 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 379.0
TLS2_k127_6786036_2 O-Antigen ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000004613 254.0
TLS2_k127_6786036_3 polysaccharide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000001744 186.0
TLS2_k127_6786036_4 Glycosyl transferase WecB/TagA/CpsF family - - - 0.000000000000000000000000000000000000000000001923 175.0
TLS2_k127_6790583_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 1.548e-316 978.0
TLS2_k127_6790583_1 Belongs to the RimK family K05844 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000727 423.0
TLS2_k127_6790583_2 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004704 425.0
TLS2_k127_6790583_3 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 396.0
TLS2_k127_6790583_4 Thiol disulfide interchange protein - - - 0.000000000000000000000000000000000000000000000000278 179.0
TLS2_k127_6790583_5 Protein of unknown function (DUF962) - - - 0.000000000000000000000000000000000000000002583 159.0
TLS2_k127_6790583_6 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000009339 134.0
TLS2_k127_6790583_7 Protein of unknown function DUF45 - - - 0.0000000000000000000000002906 106.0
TLS2_k127_6790583_8 TIGRFAM Diguanylate cyclase - - - 0.00000004998 64.0
TLS2_k127_6820890_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K13378 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 1.505e-302 938.0
TLS2_k127_6820890_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004781 350.0
TLS2_k127_6820890_2 NADH dehydrogenase K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000001169 237.0
TLS2_k127_6840706_0 FAD binding domain K00278 - 1.4.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 529.0
TLS2_k127_6840706_1 Major facilitator superfamily K19577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 518.0
TLS2_k127_6840706_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006706 436.0
TLS2_k127_6842178_0 Periplasmic binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005138 290.0
TLS2_k127_6842178_1 CobD/Cbib protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000726 252.0
TLS2_k127_6842178_2 N-acetylmuramoyl-L-alanine amidase K01447 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000006529 230.0
TLS2_k127_6842178_3 domain, Protein - - - 0.000000000000000000000000000000006411 137.0
TLS2_k127_6847160_0 Alginate export - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 335.0
TLS2_k127_6847160_1 Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001181 258.0
TLS2_k127_6847160_2 ANTAR K07183 - - 0.000000000000000000000000000000000000000000000000000000000000000001429 232.0
TLS2_k127_6847160_3 Domain of unknown function (DUF4153) - - - 0.0000000000000000000000000000000000000000000000000000000007572 228.0
TLS2_k127_6847160_4 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K15576 - - 0.00000000000000000000002263 103.0
TLS2_k127_6870439_0 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 4.91e-291 899.0
TLS2_k127_6870439_1 Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions K02553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001521 258.0
TLS2_k127_6870439_2 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.000000000000000000000000000000000000000000000000000000000002535 219.0
TLS2_k127_6870439_3 - - - - 0.000000000000000000000000000001137 128.0
TLS2_k127_6872715_0 Parallel beta-helix repeats - - - 0.0 1554.0
TLS2_k127_6872715_1 Helicase K03578 - 3.6.4.13 1.379e-253 793.0
TLS2_k127_6872715_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005367 435.0
TLS2_k127_6872715_3 receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 316.0
TLS2_k127_6872715_4 Belongs to the UPF0502 family K09915 - - 0.0000000000000000000000000000000000000000000000000000000000000000001018 239.0
TLS2_k127_6880248_0 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 353.0
TLS2_k127_6880248_1 protein conserved in bacteria K09921 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 313.0
TLS2_k127_6911103_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006058 566.0
TLS2_k127_6911103_1 GDP-mannose 4,6 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009358 329.0
TLS2_k127_6911103_2 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000001091 239.0
TLS2_k127_6911103_3 protein possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000000000000001126 188.0
TLS2_k127_6911103_4 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.000000000000000000000000000000000000000000000001928 177.0
TLS2_k127_6911103_5 helix_turn_helix, cAMP Regulatory protein - - - 0.000000000000000000000000000000000000001051 150.0
TLS2_k127_6923521_0 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 532.0
TLS2_k127_6923521_1 Glutathione S-transferase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000001758 206.0
TLS2_k127_6942213_0 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001012 281.0
TLS2_k127_6942213_1 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001385 263.0
TLS2_k127_6942213_2 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001009 267.0
TLS2_k127_6942213_3 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.00000000000000000000000000000000000000000000000000000000000000005215 232.0
TLS2_k127_6942213_4 2 iron, 2 sulfur cluster binding K02192 - - 0.000000000001284 71.0
TLS2_k127_6942213_5 Uncharacterised protein family (UPF0093) K08973 - - 0.0000001962 52.0
TLS2_k127_6946385_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - - 2e-323 1001.0
TLS2_k127_6946385_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 2.619e-201 632.0
TLS2_k127_6946385_10 MAPEG family - - - 0.00000000000000000000000000000000000002037 159.0
TLS2_k127_6946385_11 Biopolymer transport protein, ExbD K03559 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0023052,GO:0031224,GO:0031226,GO:0031647,GO:0031992,GO:0032991,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050821,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0065008,GO:0071944,GO:0098796,GO:0098797 - 0.00000000000000000000000000000000002157 139.0
TLS2_k127_6946385_12 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00001221 55.0
TLS2_k127_6946385_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 4.075e-201 630.0
TLS2_k127_6946385_3 protein conserved in bacteria K09989 - - 3.026e-195 617.0
TLS2_k127_6946385_4 AAA domain (Cdc48 subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 486.0
TLS2_k127_6946385_5 dehydratase K08678 - 4.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 331.0
TLS2_k127_6946385_6 Protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004863 289.0
TLS2_k127_6946385_7 MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005699 280.0
TLS2_k127_6946385_8 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005147 274.0
TLS2_k127_6946385_9 endonuclease III K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000002806 235.0
TLS2_k127_6977705_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 424.0
TLS2_k127_6977705_1 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003791 273.0
TLS2_k127_6977705_2 Bacterial type II and III secretion system protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001078 278.0
TLS2_k127_6977705_3 GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004956 234.0
TLS2_k127_6977705_4 COG0226 ABC-type phosphate transport system, periplasmic component - - - 0.0000000000000000000000000000005352 129.0
TLS2_k127_6979522_0 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 426.0
TLS2_k127_6979522_1 ECF sigma factor - - - 0.00000000000000000000000000000000000001206 157.0
TLS2_k127_6979522_2 TPR repeat - - - 0.00000000000000001964 87.0
TLS2_k127_7010679_0 Male sterility protein - - - 1.515e-314 979.0
TLS2_k127_7010679_1 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 512.0
TLS2_k127_7010679_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 368.0
TLS2_k127_7010679_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 319.0
TLS2_k127_7010679_4 pteridine-dependent deoxygenase K18240 - 4.1.3.40,4.1.3.45 0.00000000000000000000000000000000000000000000000000000000000000000000000002327 263.0
TLS2_k127_7010679_5 Protein of unknown function (DUF3187) - - - 0.00000000000000000000000000000000000000000000000003714 188.0
TLS2_k127_7028782_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K18687 - 6.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 587.0
TLS2_k127_7028782_1 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006094 495.0
TLS2_k127_7028782_2 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008231 419.0
TLS2_k127_7028782_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 394.0
TLS2_k127_7028782_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008793 378.0
TLS2_k127_7028782_5 3-oxo-5-alpha-steroid 4-dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 376.0
TLS2_k127_7028782_6 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 376.0
TLS2_k127_7028782_7 Coenzyme A transferase - - - 0.0000000000000000000000000000000000000000000000000000000005909 205.0
TLS2_k127_7028782_8 FecR protein - - - 0.000000000000000000773 96.0
TLS2_k127_7028782_9 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000003204 81.0
TLS2_k127_7044954_0 accessory protein K06959 - - 3.383e-290 899.0
TLS2_k127_7044954_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K05962 - 2.7.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007037 280.0
TLS2_k127_7069769_0 Glutathione S-transferase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 359.0
TLS2_k127_7069769_1 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000000001168 197.0
TLS2_k127_7069769_2 Protein of unknown function (DUF2938) - - - 0.0000000000000000000000000000000000000000000000000129 184.0
TLS2_k127_7069769_3 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000005576 144.0
TLS2_k127_7119045_0 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007553 501.0
TLS2_k127_7119045_1 Acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 353.0
TLS2_k127_7119045_2 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000001376 262.0
TLS2_k127_7119045_3 Penicillin acylase K01434 - 3.5.1.11 0.00000000000000000000000000000000000000000000000000000000000000000008076 263.0
TLS2_k127_7119045_4 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000000000000000000000000000000000000001715 169.0
TLS2_k127_7119045_5 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.00000000000000000000000000000000002168 135.0
TLS2_k127_7119106_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K11745,K11747 - - 4.685e-201 643.0
TLS2_k127_7119106_1 Zinc carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 512.0
TLS2_k127_7119106_10 Protein conserved in bacteria - - - 0.00000000000000000000000000000003663 130.0
TLS2_k127_7119106_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008511 475.0
TLS2_k127_7119106_3 asparaginase K13051 - 3.4.19.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005377 422.0
TLS2_k127_7119106_4 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 309.0
TLS2_k127_7119106_5 Peptidoglycan-synthase activator LpoB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001188 248.0
TLS2_k127_7119106_6 phospholipase K01058 - 3.1.1.32,3.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000006212 247.0
TLS2_k127_7119106_7 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000005124 225.0
TLS2_k127_7119106_8 Curli production assembly/transport component CsgG - - - 0.00000000000000000000000000000000000000000000000001822 193.0
TLS2_k127_7119106_9 Thioredoxin-like - - - 0.00000000000000000000000000000000000008346 161.0
TLS2_k127_7129835_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001448 244.0
TLS2_k127_7129835_1 maltose O-acetyltransferase activity K03818 - - 0.0000000000000000000000000000000000000000000000000000000000002411 222.0
TLS2_k127_7129835_2 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000001268 169.0
TLS2_k127_7137009_0 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 607.0
TLS2_k127_7137009_1 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004316 604.0
TLS2_k127_7137009_2 Pseudouridylate K06177 - 5.4.99.28,5.4.99.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006752 368.0
TLS2_k127_7137009_3 UPF0114 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 321.0
TLS2_k127_7137009_4 Flavin containing amine oxidoreductase K09516,K09835 - 1.3.99.23,5.2.1.13 0.000000000000000000000000000000000000000000000000000000000003325 209.0
TLS2_k127_7137009_5 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000000000000000000000000000000001314 148.0
TLS2_k127_71471_0 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004825 567.0
TLS2_k127_71471_1 Protein of unknown function (DUF1329) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 297.0
TLS2_k127_71471_2 Protein of unknown function (DUF2505) - - - 0.0000000000000000000000000000000000000000000001525 184.0
TLS2_k127_71471_3 Rubredoxin - - - 0.000000000000000000000009703 103.0
TLS2_k127_715112_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005852 512.0
TLS2_k127_715112_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 399.0
TLS2_k127_715112_2 heptosyltransferase K12982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 367.0
TLS2_k127_715112_3 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272,K21344 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008219,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0012501,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016779,GO:0019200,GO:0033692,GO:0033785,GO:0033786,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0070566,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 342.0
TLS2_k127_715112_4 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003411 254.0
TLS2_k127_7166171_0 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K01841,K03417 - 4.1.3.30,5.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 494.0
TLS2_k127_7166171_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007285 369.0
TLS2_k127_7166171_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004938 342.0
TLS2_k127_7166171_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000000000000000000000000001242 213.0
TLS2_k127_7166171_4 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000002459 148.0
TLS2_k127_7166171_5 Belongs to the citrate synthase family K01659 - 2.3.3.5 0.000000000000000008376 83.0
TLS2_k127_7166171_6 - - - - 0.0000002563 53.0
TLS2_k127_7179341_0 PFAM Glycosyl transferases group 1 K16703 - - 0.000000000000000000000000000000000000000000000000005824 204.0
TLS2_k127_7179341_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000009864 195.0
TLS2_k127_7179341_2 STELLO glycosyltransferases - - - 0.000000499 52.0
TLS2_k127_7179341_3 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.000005871 52.0
TLS2_k127_7208820_0 Activates fatty acids by binding to coenzyme A K01897 - 6.2.1.3 8.359e-253 786.0
TLS2_k127_7208820_1 Belongs to the SAICAR synthetase family K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 449.0
TLS2_k127_7208820_2 UPF0761 membrane protein K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 372.0
TLS2_k127_7208820_3 MAPEG family - - - 0.00000000000000000000000000000000000000000000000009641 179.0
TLS2_k127_7208820_4 - - - - 0.00000000000000000000005058 102.0
TLS2_k127_7208820_5 - - - - 0.000000000000000000001509 105.0
TLS2_k127_7208820_7 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000005419 66.0
TLS2_k127_722329_0 TonB dependent receptor - - - 5.582e-205 660.0
TLS2_k127_722329_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000008743 160.0
TLS2_k127_722329_2 Iron-regulated membrane protein - - - 0.0001282 46.0
TLS2_k127_7234173_0 desaturase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006123 564.0
TLS2_k127_7234173_1 AraC family transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 426.0
TLS2_k127_7234173_2 Ethanolamine ammonia-lyase light chain (EutC) K03736 - 4.3.1.7 0.0000000000000000000000000000000000000000000000000000000187 199.0
TLS2_k127_7234173_3 Oxidoreductase - - - 0.0000000000000000000000000000006324 123.0
TLS2_k127_7234298_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1074.0
TLS2_k127_7234298_1 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002794 587.0
TLS2_k127_7234298_10 Phage shock protein B K03970 - - 0.0000001239 57.0
TLS2_k127_7234298_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005437 545.0
TLS2_k127_7234298_3 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 466.0
TLS2_k127_7234298_4 Domain of unknown function (DUF4394) - - - 0.000000000000000000000000000000000000000000000000000000000000007503 226.0
TLS2_k127_7234298_5 COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription K03969 GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000008708 181.0
TLS2_k127_7234298_6 PIN domain K18828 - - 0.00000000000000000000000000003511 122.0
TLS2_k127_7234298_7 - - - - 0.0000000000000000000000000002649 115.0
TLS2_k127_7234298_8 PspC domain - - - 0.00000000000000000007508 99.0
TLS2_k127_7234298_9 - - - - 0.0000000000000000001167 92.0
TLS2_k127_7239740_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006917 489.0
TLS2_k127_7239740_1 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006178 332.0
TLS2_k127_7239740_2 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001863 286.0
TLS2_k127_7239740_3 4'-phosphopantetheinyl transferase superfamily - - - 0.000000000000000000000000000009166 132.0
TLS2_k127_7239740_4 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0001447 52.0
TLS2_k127_7248678_0 Methyl-transferase K06983 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 406.0
TLS2_k127_7248678_1 Domain of unknown function (DUF1794) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006837 362.0
TLS2_k127_7248678_2 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 301.0
TLS2_k127_726363_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004803 597.0
TLS2_k127_726363_1 AsmA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006668 563.0
TLS2_k127_726363_2 glycosylase K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 410.0
TLS2_k127_726363_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000006438 106.0
TLS2_k127_7264958_0 Histidine kinase K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 556.0
TLS2_k127_7264958_1 COG0226 ABC-type phosphate transport system, periplasmic component K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005544 474.0
TLS2_k127_7264958_2 Phosphate-selective porin O and P K07221 - - 0.000000000000000000000000000000000000000000000009092 181.0
TLS2_k127_730141_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001242 238.0
TLS2_k127_730141_1 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000001999 191.0
TLS2_k127_730141_2 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000001014 164.0
TLS2_k127_730141_3 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000882 115.0
TLS2_k127_7317863_0 receptor K02014 - - 8.736e-305 944.0
TLS2_k127_7317863_1 PFAM Cytochrome P450 - - - 6.932e-220 690.0
TLS2_k127_7317863_2 PFAM regulatory protein LuxR K03556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001342 272.0
TLS2_k127_7317863_3 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.0000000000000000000000000000000000000000003533 162.0
TLS2_k127_7317863_4 Protein of unknown function (DUF2834) - - - 0.0000000000000000000000000000000000001602 148.0
TLS2_k127_7317863_5 TonB C terminal K03832 - - 0.000000000000000000000000009695 119.0
TLS2_k127_7326481_0 aminopeptidase K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 598.0
TLS2_k127_7326481_1 hydroxylase K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005324 467.0
TLS2_k127_7326481_2 Catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol K03184,K18800 - - 0.000000000000000000000000000000000000000000000000000000000000000002266 241.0
TLS2_k127_7326481_3 Belongs to the UPF0149 family K09895 - - 0.000000000000000000000000000000000000000000000000002498 188.0
TLS2_k127_7326481_4 Amino acid kinase family - - - 0.000000001322 63.0
TLS2_k127_7342775_0 Glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 2350.0
TLS2_k127_7342775_1 Phosphohydrolase-associated domain K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 514.0
TLS2_k127_7342775_2 Glutamate synthase K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000004594 199.0
TLS2_k127_7349600_0 MMPL family - - - 0.0 1279.0
TLS2_k127_7349600_1 Protein of unknown function (DUF1302) - - - 0.0 1043.0
TLS2_k127_7349600_10 - - - - 0.000000000000000000000007053 110.0
TLS2_k127_7349600_2 Protein of unknown function (DUF1329) - - - 9.277e-247 771.0
TLS2_k127_7349600_3 Flavin-binding monooxygenase-like K07222 - - 3.593e-208 657.0
TLS2_k127_7349600_4 Major facilitator superfamily - - - 1.373e-205 647.0
TLS2_k127_7349600_5 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004655 492.0
TLS2_k127_7349600_6 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001344 284.0
TLS2_k127_7349600_7 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000001858 249.0
TLS2_k127_7349600_8 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000002511 240.0
TLS2_k127_7349600_9 Photosynthesis system II assembly factor YCF48 - - - 0.000000000000000000000000000000000000000000000000000000002852 203.0
TLS2_k127_7381432_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 497.0
TLS2_k127_7381432_1 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009764 482.0
TLS2_k127_7381432_2 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006704 330.0
TLS2_k127_7409894_0 Cytochrome c - - - 1.448e-201 641.0
TLS2_k127_7409894_1 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000001775 214.0
TLS2_k127_7416910_0 ABC transporter transmembrane region K06147 - - 8.901e-215 684.0
TLS2_k127_7416910_1 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 547.0
TLS2_k127_7416910_10 Cold shock protein domain K03704 - - 0.00000000000000000000643 99.0
TLS2_k127_7416910_2 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 432.0
TLS2_k127_7416910_3 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005935 390.0
TLS2_k127_7416910_4 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 378.0
TLS2_k127_7416910_5 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 339.0
TLS2_k127_7416910_6 Inositol monophosphatase family K05602 - 3.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 325.0
TLS2_k127_7416910_7 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 302.0
TLS2_k127_7416910_8 Glycosyl hydrolases family 16 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000636 304.0
TLS2_k127_7416910_9 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000191 281.0
TLS2_k127_7438443_0 O-acetylhomoserine K01740 - 2.5.1.49 2.811e-243 756.0
TLS2_k127_7438443_1 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006381 310.0
TLS2_k127_7438443_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003033 282.0
TLS2_k127_7438443_3 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000003933 175.0
TLS2_k127_7438443_4 TonB-dependent Receptor Plug K02014 - - 0.00000000000000000000000000000000000000007724 156.0
TLS2_k127_7440671_0 Glycosyl transferase family 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 507.0
TLS2_k127_7440671_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006463 418.0
TLS2_k127_7440671_2 membrane protein terc - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007179 348.0
TLS2_k127_7440671_3 HD domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 321.0
TLS2_k127_7440671_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008571 326.0
TLS2_k127_7440671_5 Uroporphyrinogen-III synthase K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000002619 209.0
TLS2_k127_7440671_6 enzyme of heme biosynthesis K02496,K13543 - 2.1.1.107,4.2.1.75 0.00001271 50.0
TLS2_k127_765116_0 Acts as a magnesium transporter K06213 - - 7.516e-199 631.0
TLS2_k127_765116_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 522.0
TLS2_k127_765116_10 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.000000000000000000000000000000000000000000000000000000000000009009 222.0
TLS2_k127_765116_11 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000000000000000000002339 190.0
TLS2_k127_765116_12 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000000000000000001437 129.0
TLS2_k127_765116_13 Belongs to the bacterial ribosomal protein bL33 family K02913 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000005067 98.0
TLS2_k127_765116_2 Peptidase M48 Ste24p - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 524.0
TLS2_k127_765116_3 Acetylglutamate kinase K22478 GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003303 497.0
TLS2_k127_765116_4 SPFH domain / Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 362.0
TLS2_k127_765116_5 Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene) K09880 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019509,GO:0019752,GO:0042578,GO:0043094,GO:0043102,GO:0043436,GO:0043874,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009128 343.0
TLS2_k127_765116_6 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000881 300.0
TLS2_k127_765116_7 Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway K08967 GO:0000096,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0010309,GO:0016491,GO:0016701,GO:0016702,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0051213,GO:0055114,GO:0071704,GO:1901564,GO:1901605 1.13.11.53,1.13.11.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000001116 261.0
TLS2_k127_765116_8 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) K08964 - 4.2.1.109 0.0000000000000000000000000000000000000000000000000000000000000000000000000925 269.0
TLS2_k127_765116_9 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000001521 247.0
TLS2_k127_778663_0 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0034214,GO:0042802,GO:0043170,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0061799,GO:0065003,GO:0071704,GO:0071840,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 351.0
TLS2_k127_778663_1 molybdopterin K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 302.0
TLS2_k127_778663_2 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002941 251.0
TLS2_k127_778663_3 Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000000000000000000000000000000001236 216.0
TLS2_k127_778663_4 Molybdopterin converting factor, large subunit K03635 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 0.00000000000000000000000000000004973 126.0
TLS2_k127_835873_0 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 597.0
TLS2_k127_835873_1 Cellulase (glycosyl hydrolase family 5) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004954 439.0
TLS2_k127_835873_2 Protein of unknown function (DUF1298) - - - 0.000000000000000000000000000000000005219 138.0
TLS2_k127_835873_3 Protein of unknown function (DUF3565) - - - 0.000000000000000000000000000131 117.0
TLS2_k127_836641_0 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 581.0
TLS2_k127_836641_1 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004442 310.0
TLS2_k127_836641_2 Domain of unknown function (DUF1905) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006143 252.0
TLS2_k127_836641_3 Predicted metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000005078 230.0
TLS2_k127_836641_4 Domain of unknown function (DUF202) K00389 - - 0.0000000000000000000000000000000000007452 143.0
TLS2_k127_836641_5 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000001412 136.0
TLS2_k127_83922_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 1.055e-278 869.0
TLS2_k127_83922_1 Acyl-CoA dehydrogenase N terminal - - - 3.65e-260 812.0
TLS2_k127_83922_2 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000002699 270.0
TLS2_k127_83922_3 Preprotein translocase subunit YajC K03210 - - 0.0000000000000000000000000000000000000000008671 158.0
TLS2_k127_83922_4 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000005837 135.0
TLS2_k127_844333_0 COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog - - - 1.351e-253 802.0
TLS2_k127_844333_1 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004442 521.0
TLS2_k127_844333_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 496.0
TLS2_k127_844333_3 Bacterial periplasmic substrate-binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 470.0
TLS2_k127_844333_4 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 352.0
TLS2_k127_844333_5 Transcriptional regulatory protein, C terminal K07666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001442 269.0
TLS2_k127_844333_6 Large family of predicted nucleotide-binding domains - - - 0.00000000000000000000000000000000000000007908 156.0
TLS2_k127_844333_7 PFAM SpoVT AbrB K07172 - - 0.00000000000000000000009262 107.0
TLS2_k127_846142_0 PhoD-like phosphatase, N-terminal domain K01113 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 319.0
TLS2_k127_846142_1 Putative auto-transporter adhesin, head GIN domain - - - 0.0000000000000000000000000000000003614 146.0
TLS2_k127_846142_2 Sulfotransferase family - - - 0.00009733 46.0
TLS2_k127_867266_0 abc transporter atp-binding protein K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 317.0
TLS2_k127_867266_1 abc transporter, permease K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004411 310.0
TLS2_k127_867266_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000009016 266.0
TLS2_k127_867266_3 MlaD protein K06192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004861 268.0
TLS2_k127_867266_4 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.0000000000000000000000000000000000000000000000000469 184.0
TLS2_k127_867266_5 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000007025 168.0
TLS2_k127_877000_0 GAF domain K21405 - - 6.03e-203 649.0
TLS2_k127_877000_1 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 384.0
TLS2_k127_877000_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000007756 234.0
TLS2_k127_877000_3 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000000000000000000000000000000000009913 235.0
TLS2_k127_877000_4 belongs to the aldehyde dehydrogenase family K00138 - - 0.00001774 47.0
TLS2_k127_898472_0 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 376.0
TLS2_k127_898472_1 Transport and Golgi organisation 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002678 260.0
TLS2_k127_898472_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000000000000000001627 205.0
TLS2_k127_898472_3 EcsC protein family - - - 0.00000000000000000000000000000002391 146.0
TLS2_k127_899137_0 Protein of unknown function (DUF1329) - - - 1.635e-214 673.0
TLS2_k127_899137_1 Protein of unknown function (DUF1302) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000701 456.0
TLS2_k127_899137_2 A predicted alpha-helical domain with a conserved ER motif. - - - 0.00000000000000000000000000000000000000000000000000000000000003825 217.0
TLS2_k127_913167_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 7.618e-201 629.0
TLS2_k127_913167_1 Domain of unknown function DUF21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004077 581.0
TLS2_k127_913167_2 transport system permease component - - - 0.00000000000000000000000000000000000000000000000000000000000001032 225.0
TLS2_k127_930223_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1422.0
TLS2_k127_930223_1 PFAM major facilitator superfamily MFS_1 - - - 1.055e-198 629.0
TLS2_k127_930223_2 Belongs to the pseudouridine synthase RsuA family K06182 - 5.4.99.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 316.0
TLS2_k127_930223_3 HI0933-like protein K07007 - - 0.00000000000000000000000002631 108.0
TLS2_k127_930223_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000006769 85.0
TLS2_k127_945979_0 Cellulase (glycosyl hydrolase family 5) K01179 - 3.2.1.4 0.0000000000000000000000000000000000000806 163.0
TLS2_k127_945979_1 amine dehydrogenase activity K01077,K01126,K01406,K02396,K07004 - 3.1.3.1,3.1.4.46,3.4.24.40 0.000000001109 72.0
TLS2_k127_950148_0 Sodium alanine symporter K03310 - - 2.375e-239 747.0
TLS2_k127_950148_1 Zn-dependent hydrolases including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004614 445.0
TLS2_k127_950148_2 Acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 302.0
TLS2_k127_950148_3 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000004667 203.0
TLS2_k127_950148_4 Multidrug Resistance protein K11741 - - 0.000000000000000000000000000000000000004447 148.0
TLS2_k127_95156_0 ABC1 family - - - 2.598e-290 912.0
TLS2_k127_95156_1 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 554.0
TLS2_k127_95156_2 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003108 416.0
TLS2_k127_95156_3 OmpA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 294.0
TLS2_k127_95156_4 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004182 275.0
TLS2_k127_95156_5 - - - - 0.0000000000000000000000000000000000002014 148.0
TLS2_k127_981988_0 polyphosphate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 395.0
TLS2_k127_981988_1 Acetyl-coenzyme A transporter 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 362.0
TLS2_k127_981988_2 hemolysin III K11068 - - 0.00000000000000000000000000000000000000000000000000000000000001696 222.0
TLS2_k127_981988_3 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000121 201.0
TLS2_k127_981988_4 WYL domain - - - 0.0000000000000000000000000000000000000000000000004545 178.0
TLS2_k127_981988_5 hemolysin III K11068 - - 0.000000000000003226 75.0