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Overview

ID MAG04003
Name TLS2_bin.39
Sample SMP0104
Taxonomy
Kingdom Archaea
Phylum Thermoproteota
Class Nitrososphaeria
Order Nitrososphaerales
Family Nitrososphaeraceae
Genus Nitrososphaera
Species
Assembly information
Completeness (%) 87.3
Contamination (%) 0.02
GC content (%) 50.0
N50 (bp) 12,967
Genome size (bp) 1,695,734

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1705

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1001882_0 DEAD DEAH box helicase K06877 - - 0.0 1325.0
TLS2_k127_1001882_1 DNA Topoisomerase I (eukaryota) K03163 - 5.99.1.2 1.859e-311 960.0
TLS2_k127_1001882_2 adenylosuccinate lyase K01756 - 4.3.2.2 1.202e-227 714.0
TLS2_k127_1001882_3 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 378.0
TLS2_k127_1001882_4 zinc finger K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 351.0
TLS2_k127_1001882_5 membrane-associated protein domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005919 360.0
TLS2_k127_1001882_6 major facilitator superfamily K08153,K08221 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 290.0
TLS2_k127_1001882_7 Belongs to the RtcB family K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000001823 210.0
TLS2_k127_108232_0 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 8.574e-265 822.0
TLS2_k127_108232_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004554 520.0
TLS2_k127_108232_2 Transposase, is605 orfb family K07496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 490.0
TLS2_k127_108232_3 acid phosphatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 306.0
TLS2_k127_108232_4 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000009467 201.0
TLS2_k127_108232_6 Spherulation-specific family 4 - - - 0.0000000000000000000000007722 118.0
TLS2_k127_108232_7 - - - - 0.000000000000000005447 92.0
TLS2_k127_108232_9 Alpha beta - - - 0.00000000002976 66.0
TLS2_k127_1090831_0 phosphonate ABC transporter, permease protein PhnE K02042 - - 0.00000000000000000000000000000000000000000000000001624 189.0
TLS2_k127_1090831_1 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.00000000000000000000000000000000000000000000000445 179.0
TLS2_k127_1090831_3 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000001327 126.0
TLS2_k127_1090831_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000000000000009234 88.0
TLS2_k127_1090831_6 - - - - 0.00000002337 61.0
TLS2_k127_109882_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0 1094.0
TLS2_k127_109882_1 methylase K00590 - 2.1.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008432 556.0
TLS2_k127_109882_2 Cob(II)yrinic acid a,c-diamide reductase K04719 - 1.13.11.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002903 389.0
TLS2_k127_109882_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000002226 232.0
TLS2_k127_109882_4 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.000000000000000000000000000000000004627 142.0
TLS2_k127_1113173_0 Carbamoyl-phosphate synthase L chain K18603 - 6.4.1.2,6.4.1.3 2.927e-286 883.0
TLS2_k127_1113173_1 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K18604 - 2.1.3.15,6.4.1.2,6.4.1.3 6.069e-236 739.0
TLS2_k127_1113173_2 Cysteine desulfurase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 455.0
TLS2_k127_1113173_3 tRNA methyl transferase K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000654 384.0
TLS2_k127_1113173_4 ATPase family associated with various cellular activities (AAA) K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007957 315.0
TLS2_k127_1113173_5 biotin carboxyl carrier K00627,K01571,K15037,K18605 - 2.3.1.12,4.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001235 279.0
TLS2_k127_1113173_6 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000001201 256.0
TLS2_k127_1113173_7 serine-type endopeptidase activity K00505,K01342,K02035 - 1.14.18.1,3.4.21.62 0.000000000000000000000000000000000000000000000000000000000000000000000000001232 261.0
TLS2_k127_1113173_8 - - - - 0.000000000000000000000000000000000000000000000006489 174.0
TLS2_k127_1113173_9 - K03646 - - 0.0000000000000000000000002987 106.0
TLS2_k127_1160142_0 archaeal coiled-coil protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 446.0
TLS2_k127_1160142_1 Belongs to the MenA family. Type 1 subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 323.0
TLS2_k127_1160142_11 Peptidase family M23 - - - 0.000000000000000000009805 97.0
TLS2_k127_1160142_12 Protein of unknown function (DUF1512) - - - 0.0001341 45.0
TLS2_k127_1160142_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004497 290.0
TLS2_k127_1160142_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005128 263.0
TLS2_k127_1160142_4 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000003186 236.0
TLS2_k127_1160142_5 Methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000003044 239.0
TLS2_k127_1160142_6 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000000001137 190.0
TLS2_k127_1160142_7 transcriptional regulators K03711,K09825 - - 0.000000000000000000000000000000000000000000000001176 177.0
TLS2_k127_1160142_8 - - - - 0.0000000000000000000000000000000000000000000001137 168.0
TLS2_k127_1160142_9 4-hydroxybenzoate synthetase (chorismate lyase) K03181,K06984 - 2.4.2.54,4.1.3.40 0.000000000000000000000000000000000002595 143.0
TLS2_k127_1181411_0 Phosphate uptake regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 593.0
TLS2_k127_1181411_1 Sodium:sulfate symporter transmembrane region K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005852 592.0
TLS2_k127_1181411_10 Activator of Hsp90 ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000001274 229.0
TLS2_k127_1181411_11 Patch-forming domain C2 of tRNA-guanine transglycosylase K07398 - - 0.00000000000000000000000000000000000000000000000000000000000005014 221.0
TLS2_k127_1181411_12 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000000000000000000000000000000001429 201.0
TLS2_k127_1181411_13 transcription factor, homolog of eukaryotic MBF1 K03627 - - 0.0000000000000000000000000000000000000000000000000000001705 196.0
TLS2_k127_1181411_14 regulatory protein, arsR - - - 0.0000000000000000000000000000000000000000000001676 169.0
TLS2_k127_1181411_15 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000004393 157.0
TLS2_k127_1181411_16 H subunit K02107 - - 0.000000000000000000000000000000000001244 142.0
TLS2_k127_1181411_17 - - - - 0.0000000000000001583 86.0
TLS2_k127_1181411_18 - - - - 0.0000000000000002554 85.0
TLS2_k127_1181411_19 Spherulation-specific family 4 - - - 0.00000000000002373 88.0
TLS2_k127_1181411_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 553.0
TLS2_k127_1181411_20 Domain of unknown function (DUF4332) - - - 0.00001657 55.0
TLS2_k127_1181411_3 Mg2 transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 356.0
TLS2_k127_1181411_5 Glucose / Sorbosone dehydrogenase K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005853 352.0
TLS2_k127_1181411_6 PFAM Integrase core domain K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004493 314.0
TLS2_k127_1181411_7 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 313.0
TLS2_k127_1181411_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003231 250.0
TLS2_k127_1181411_9 Transposase, IS605 OrfB family K07496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001012 254.0
TLS2_k127_1268845_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 9.139e-211 659.0
TLS2_k127_1268845_1 TIGRFAM precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 419.0
TLS2_k127_1268845_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004562 272.0
TLS2_k127_1268845_3 NADH ubiquinone oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000005331 192.0
TLS2_k127_1268845_5 COG1522 Transcriptional regulators - - - 0.0000003779 53.0
TLS2_k127_1283745_0 Zn-dependent protease with chaperone function K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003821 364.0
TLS2_k127_1283745_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000007599 229.0
TLS2_k127_1283745_4 Pyridine nucleotide-disulfide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000006653 108.0
TLS2_k127_1283745_5 Probable transposase K07496 - - 0.0000000000000000006263 89.0
TLS2_k127_1283745_8 - - - - 0.000002697 53.0
TLS2_k127_1283745_9 - - - - 0.0001347 53.0
TLS2_k127_1283834_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 2.535e-229 713.0
TLS2_k127_1283834_1 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily K05829 - - 1.121e-224 697.0
TLS2_k127_1283834_10 Probable transposase K07496 - - 0.0000000000000000004564 90.0
TLS2_k127_1283834_11 - - - - 0.00002488 55.0
TLS2_k127_1283834_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K05830 - - 5.389e-221 690.0
TLS2_k127_1283834_3 Lysine biosynthesis K05827 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005685 516.0
TLS2_k127_1283834_4 Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) K05828 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006579 494.0
TLS2_k127_1283834_5 Cobalamin B12-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 479.0
TLS2_k127_1283834_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 394.0
TLS2_k127_1283834_7 glucosylceramidase activity - - - 0.00000000000000000000000000000000000000000000000000000000843 201.0
TLS2_k127_1283834_8 FUN14 family - - - 0.0000000000000000000000000000000000283 138.0
TLS2_k127_1283834_9 lysine biosynthesis protein LysW K05826 - - 0.0000000000000000000000000000001815 123.0
TLS2_k127_1328735_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 1.188e-271 844.0
TLS2_k127_1328735_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K03294,K20989 - - 0.00000000000000000000000000000000000000000000000000000000002184 208.0
TLS2_k127_1466905_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 1.243e-256 797.0
TLS2_k127_1466905_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005278 346.0
TLS2_k127_1466905_2 UPF0056 membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001364 275.0
TLS2_k127_1466905_4 PFAM CBS domain containing protein - - - 0.0000000000000005878 83.0
TLS2_k127_1466905_5 Transcriptional regulator - - - 0.0000006536 54.0
TLS2_k127_148808_0 Glycosyl transferase family group 2 - - - 2.052e-296 919.0
TLS2_k127_148808_1 Hydroxymethylglutaryl-coenzyme A synthase N terminal K01641 - 2.3.3.10 3.216e-279 861.0
TLS2_k127_148808_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007622 400.0
TLS2_k127_148808_11 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006544 385.0
TLS2_k127_148808_12 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008237 369.0
TLS2_k127_148808_13 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003063 373.0
TLS2_k127_148808_14 ERCC4 domain K10848 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004679 357.0
TLS2_k127_148808_15 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005365 349.0
TLS2_k127_148808_16 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001239 278.0
TLS2_k127_148808_17 Protein of unknown function (DUF432) K09149 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000179 274.0
TLS2_k127_148808_18 ribosomal protein K02883 - - 0.000000000000000000000000000000000000000000000000000000001499 201.0
TLS2_k127_148808_19 PIN domain of ribonuclease K07060 - - 0.0000000000000000000000000000000000000000000000000000004068 197.0
TLS2_k127_148808_2 ferredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 574.0
TLS2_k127_148808_20 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.000000000000000000000000000000000000000000000000000002763 192.0
TLS2_k127_148808_21 - - - - 0.00000000000000000000000000000000000000000000000000001338 189.0
TLS2_k127_148808_22 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000003626 189.0
TLS2_k127_148808_23 Domain of unknown function (DUF2024) - - - 0.0000000000000000000000000000000000000000000000005402 175.0
TLS2_k127_148808_24 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000004699 91.0
TLS2_k127_148808_25 response to abiotic stimulus - - - 0.00000000001655 67.0
TLS2_k127_148808_26 Binds to the 23S rRNA K02921 - - 0.000000002131 61.0
TLS2_k127_148808_3 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004652 556.0
TLS2_k127_148808_4 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 464.0
TLS2_k127_148808_5 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 452.0
TLS2_k127_148808_6 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 450.0
TLS2_k127_148808_7 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004901 433.0
TLS2_k127_148808_8 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 426.0
TLS2_k127_148808_9 DNA-directed RNA polymerase, alpha subunit 40 kD subunit K03047 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 416.0
TLS2_k127_1545256_0 Tyrosine--tRNA ligase K01866 - 6.1.1.1 3.388e-204 637.0
TLS2_k127_1545256_1 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009513 510.0
TLS2_k127_1545256_2 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 305.0
TLS2_k127_1545256_3 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000007775 213.0
TLS2_k127_1620695_0 Urease, alpha subunit K01428 - 3.5.1.5 6.97e-322 990.0
TLS2_k127_1620695_1 PFAM TCP-1 cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 3.35e-251 785.0
TLS2_k127_1620695_11 - - - - 0.00000000000000000000000001032 110.0
TLS2_k127_1620695_2 TIGRFAM 2-methylcitrate synthase citrate synthase II K01647 - 2.3.3.1 3.744e-234 726.0
TLS2_k127_1620695_3 Luciferase-like monooxygenase K14728 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 417.0
TLS2_k127_1620695_4 Malic enzyme K00027 - 1.1.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009154 382.0
TLS2_k127_1620695_5 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000633 349.0
TLS2_k127_1620695_6 Urease beta subunit K01429 - 3.5.1.5 0.0000000000000000000000000000000000000000000000000000000016 201.0
TLS2_k127_1620695_7 (urease) gamma subunit K01430 - 3.5.1.5 0.0000000000000000000000000000000000000000000001028 169.0
TLS2_k127_1620695_9 PFAM Nickel cobalt transporter, high-affinity - - - 0.00000000000000000000000000000000000000000001648 172.0
TLS2_k127_1651157_0 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 1.102e-206 646.0
TLS2_k127_1651157_1 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 1.506e-195 619.0
TLS2_k127_1651157_2 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009836 418.0
TLS2_k127_1651157_3 hydrolase (HAD superfamily) K01091,K01560,K01561,K07025 - 3.1.3.18,3.8.1.2,3.8.1.3 0.0000000000000000000000000000000000000000000000000000000000000263 216.0
TLS2_k127_1651157_4 - - - - 0.00000000000000000000000000000000000000005356 154.0
TLS2_k127_1651157_5 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 - - 0.00000000000000000000000000000000000198 145.0
TLS2_k127_1651157_6 Transcriptional regulator - - - 0.0000000000000000000000000000000004743 132.0
TLS2_k127_1694016_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1188.0
TLS2_k127_1694016_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.34e-296 912.0
TLS2_k127_1694016_10 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000001429 152.0
TLS2_k127_1694016_2 GTPase of unknown function C-terminal K06942 - - 4.7e-239 741.0
TLS2_k127_1694016_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004409 414.0
TLS2_k127_1694016_4 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 400.0
TLS2_k127_1694016_5 biotin-(Acetyl-CoA-carboxylase) ligase K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007246 402.0
TLS2_k127_1694016_6 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001352 243.0
TLS2_k127_1694016_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000011 241.0
TLS2_k127_1694016_8 - - - - 0.000000000000000000000000000000000000000000000007397 174.0
TLS2_k127_1694016_9 - - - - 0.000000000000000000000000000000000000000001209 159.0
TLS2_k127_1696991_0 PFAM beta-lactamase domain protein K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 489.0
TLS2_k127_1696991_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008541 467.0
TLS2_k127_1696991_2 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 452.0
TLS2_k127_1696991_3 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006099 297.0
TLS2_k127_1696991_4 toxin-antitoxin pair type II binding - - - 0.00000002064 58.0
TLS2_k127_176021_0 DNA methylase K00590 - 2.1.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 460.0
TLS2_k127_176021_1 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX K17759 - 5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 333.0
TLS2_k127_176021_2 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 311.0
TLS2_k127_176021_3 - - - - 0.0000000000000000000000000000000000000000001154 162.0
TLS2_k127_1912844_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K01953,K06927 - 6.3.1.14,6.3.5.4 3.496e-231 727.0
TLS2_k127_1912844_1 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 356.0
TLS2_k127_1912844_10 - - - - 0.000000000009157 67.0
TLS2_k127_1912844_11 PIN domain - - - 0.0000000006939 66.0
TLS2_k127_1912844_12 COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system K06218 - - 0.00000004992 58.0
TLS2_k127_1912844_13 COG1522 Transcriptional regulators - - - 0.000007783 52.0
TLS2_k127_1912844_14 PilT protein domain protein - - - 0.0001028 45.0
TLS2_k127_1912844_15 Fic/DOC family - - - 0.0008015 48.0
TLS2_k127_1912844_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000472 215.0
TLS2_k127_1912844_3 Domain of unknown function (DUF368) K08974 - - 0.0000000000000000000000000000000000000000005642 169.0
TLS2_k127_1912844_4 DSBA oxidoreductase - - - 0.0000000000000000000000000000000000000005345 158.0
TLS2_k127_1912844_6 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000000000000000000000004324 106.0
TLS2_k127_1912844_7 Fic/DOC family - - - 0.0000000000000000000001171 106.0
TLS2_k127_1912844_8 - - - - 0.000000000000000000001441 101.0
TLS2_k127_1912844_9 xylanase chitin deacetylase K01385,K22278 - 3.4.23.42,3.5.1.104 0.00000000000000005932 87.0
TLS2_k127_1917826_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 3.125e-314 968.0
TLS2_k127_1917826_1 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 2.713e-252 781.0
TLS2_k127_1917826_10 Transcriptional regulator K07332 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 290.0
TLS2_k127_1917826_12 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K00363,K15762 - 1.7.1.15 0.00000000000000000000000000000000000000000000000000000007181 197.0
TLS2_k127_1917826_13 Cytidylyltransferase-like K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000009704 193.0
TLS2_k127_1917826_14 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000000000000000000000000002194 186.0
TLS2_k127_1917826_15 - - - - 0.000000000000000000000000000000000000000001583 156.0
TLS2_k127_1917826_16 Belongs to the SUI1 family K03113 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000003712 141.0
TLS2_k127_1917826_17 NADH ubiquinone oxidoreductase - - - 0.00000000000000000000000000000004378 124.0
TLS2_k127_1917826_18 Transposase, is605 orfb family K07496 - - 0.0000000000000000000000000000001264 125.0
TLS2_k127_1917826_2 PFAM tRNA synthetases class I (C) catalytic domain K01883 - 6.1.1.16 3.189e-232 725.0
TLS2_k127_1917826_21 Nadph-dependent fmn reductase K00299 - 1.5.1.38 0.0000000000000000000004236 103.0
TLS2_k127_1917826_22 Transposase, is605 orfb family K07496 - - 0.000000000000000000002433 93.0
TLS2_k127_1917826_23 Transposase, is605 orfb family K07496 - - 0.00000000000000000011 92.0
TLS2_k127_1917826_24 Transposase, is605 orfb family K07496 - - 0.00000000009672 64.0
TLS2_k127_1917826_3 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 593.0
TLS2_k127_1917826_4 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 498.0
TLS2_k127_1917826_6 Transposase, is605 orfb family K07496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005195 417.0
TLS2_k127_1917826_7 Methyltransferase type 11 K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006209 399.0
TLS2_k127_1917826_8 Belongs to the Pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005524 334.0
TLS2_k127_1917826_9 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 321.0
TLS2_k127_1918879_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 1.572e-257 799.0
TLS2_k127_1918879_1 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008449 498.0
TLS2_k127_1918879_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000003025 225.0
TLS2_k127_1938571_0 FAD linked - - - 7.672e-212 666.0
TLS2_k127_1938571_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 6.822e-209 653.0
TLS2_k127_1938571_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 595.0
TLS2_k127_1938571_3 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006568 420.0
TLS2_k127_1938571_4 DNA-directed RNA polymerase K03049 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 361.0
TLS2_k127_1938571_5 Belongs to the UPF0218 family K09735 - - 0.000000000000000000000000000000000000000000000000000000000000048 217.0
TLS2_k127_1938571_6 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.00000000000000000000000000000000000000000000000000000000001225 210.0
TLS2_k127_1938571_7 - - - - 0.0000000000000000000000000000000000000000000004317 166.0
TLS2_k127_1938571_8 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000000000000000000000007518 121.0
TLS2_k127_1938571_9 Ribosomal protein S30 K02983 - - 0.00000000000000000000000000003047 116.0
TLS2_k127_2018420_0 SMC proteins Flexible Hinge Domain K03529 - - 0.0 1709.0
TLS2_k127_2018420_1 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 2.801e-223 698.0
TLS2_k127_2018420_10 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.000000000000000000000000000000000002728 139.0
TLS2_k127_2018420_11 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.0000000000000000000000000000000001349 133.0
TLS2_k127_2018420_12 - - - - 0.00000000000000000000000000003271 118.0
TLS2_k127_2018420_13 - - - - 0.000000000000008505 77.0
TLS2_k127_2018420_14 - - - - 0.0001086 45.0
TLS2_k127_2018420_2 PFAM Radical SAM domain protein - - - 8.526e-217 678.0
TLS2_k127_2018420_3 antibiotic catabolic process K18235 - - 3.079e-197 628.0
TLS2_k127_2018420_4 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000929 575.0
TLS2_k127_2018420_5 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007847 383.0
TLS2_k127_2018420_6 Lysine exporter protein LysE YggA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001854 263.0
TLS2_k127_2018420_7 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.00000000000000000000000000000000000000000000000000000000000006938 214.0
TLS2_k127_2018420_8 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000007006 187.0
TLS2_k127_2018420_9 Peptidyl-tRNA hydrolase PTH2 K04794 - 3.1.1.29 0.00000000000000000000000000000000000000000000000006399 179.0
TLS2_k127_2019613_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 2.02e-269 835.0
TLS2_k127_2019613_1 DEAD DEAH box helicase K05592 - 3.6.4.13 7.783e-236 735.0
TLS2_k127_2019613_2 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001314 277.0
TLS2_k127_2019613_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001486 276.0
TLS2_k127_2019613_4 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002485 251.0
TLS2_k127_2019613_5 zinc-ribbon domain - - - 0.0000000000000000000000000000000000000000000000000000000000000007434 221.0
TLS2_k127_2019613_6 NADH ubiquinone oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000005331 192.0
TLS2_k127_2126463_0 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 545.0
TLS2_k127_2126463_12 Transposase, is605 orfb family K07496 - - 0.000001867 51.0
TLS2_k127_2126463_2 Domain of unknown function (DUF2088) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 432.0
TLS2_k127_2126463_3 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 382.0
TLS2_k127_2126463_4 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 364.0
TLS2_k127_2126463_5 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 317.0
TLS2_k127_2126463_6 FR47-like protein K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 306.0
TLS2_k127_2126463_7 Signal peptidase K13280 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006907 293.0
TLS2_k127_2126463_8 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004775 265.0
TLS2_k127_2126463_9 Dodecin K09165 - - 0.00000000000000000000000004247 108.0
TLS2_k127_2298377_0 PFAM Glycosyl transferase family 2 - - - 5.301e-219 685.0
TLS2_k127_2298377_1 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 578.0
TLS2_k127_2298377_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 509.0
TLS2_k127_2298377_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 423.0
TLS2_k127_2298377_4 zinc finger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 393.0
TLS2_k127_2298377_5 COG1335 Amidases related to nicotinamidase K09020 - 3.5.1.110 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 355.0
TLS2_k127_2298377_6 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000061 298.0
TLS2_k127_2298377_7 Domain of unknown function (DUF2024) - - - 0.00000000000000000000000000000000000000000000000000000000006533 205.0
TLS2_k127_2298377_8 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000004639 204.0
TLS2_k127_2298377_9 Major Facilitator Superfamily - - - 0.00000000000000000000003599 101.0
TLS2_k127_2369231_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0050897,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.17.19 7.5e-280 865.0
TLS2_k127_2369231_1 Zinc-binding dehydrogenase K13979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009892 332.0
TLS2_k127_2369231_2 Transposase, is605 orfb family K07496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003893 255.0
TLS2_k127_2430291_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0 1143.0
TLS2_k127_2430291_1 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.0 1008.0
TLS2_k127_2430291_10 SpoVT / AbrB like domain - - - 0.00085 45.0
TLS2_k127_2430291_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 5.051e-280 863.0
TLS2_k127_2430291_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005473 391.0
TLS2_k127_2430291_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 312.0
TLS2_k127_2430291_5 CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 295.0
TLS2_k127_2430291_6 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000000000000000000005118 167.0
TLS2_k127_2430291_7 - - - - 0.000000000000000000002283 95.0
TLS2_k127_2430291_8 ATP synthase subunit C K02124 - - 0.00000006636 55.0
TLS2_k127_2438534_0 oxidoreductase FAD NAD(P)-binding K00523,K00528 - 1.17.1.1,1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 461.0
TLS2_k127_2438534_1 Serine threonine protein kinase involved in cell cycle control K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 370.0
TLS2_k127_2438534_2 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 315.0
TLS2_k127_2438534_3 K homology RNA-binding domain K06961 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 288.0
TLS2_k127_2438534_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000001553 218.0
TLS2_k127_2438534_5 Protein of unknown function (DUF424) K09148 - - 0.00000000000000000000000000000000000000079 150.0
TLS2_k127_2471596_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000811 604.0
TLS2_k127_2471596_1 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002829 277.0
TLS2_k127_2471596_2 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.0000000000000000000000000000000000000000000000001408 181.0
TLS2_k127_2471596_3 transcriptional - - - 0.000000009354 59.0
TLS2_k127_2483912_0 DHHA1 domain K07463 - - 1.86e-266 825.0
TLS2_k127_2483912_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 532.0
TLS2_k127_2483912_2 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 404.0
TLS2_k127_2483912_3 ribosomal protein K02956 - - 0.000000000000000000000000000000000000000000000000000000000000000000006067 236.0
TLS2_k127_2483912_4 RNA binding K07581 - - 0.00000000000000000000000000000000000000000000000000004626 190.0
TLS2_k127_2527930_0 aconitate hydratase K01681 - 4.2.1.3 0.0 1136.0
TLS2_k127_2527930_1 Belongs to the PdxS SNZ family K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 576.0
TLS2_k127_2527930_2 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006626 551.0
TLS2_k127_2527930_3 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005534 333.0
TLS2_k127_2527930_4 - - - - 0.0000000000000000000000000000000000000000002122 164.0
TLS2_k127_252847_0 RNA-metabolising metallo-beta-lactamase K07041 - - 0.0 1214.0
TLS2_k127_252847_1 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 5.337e-254 788.0
TLS2_k127_252847_11 - - - - 0.0000000000000000000000000000000000000000000000000001133 187.0
TLS2_k127_252847_13 Belongs to the UPF0147 family K09721 - - 0.00000000000000000000000000000000000000000006992 162.0
TLS2_k127_252847_18 nucleotidyltransferase activity - - - 0.0000000000000001436 80.0
TLS2_k127_252847_2 ATP-grasp domain K01903 - 6.2.1.5 5.24e-199 624.0
TLS2_k127_252847_22 COG3316 Transposase and inactivated derivatives - - - 0.00003948 52.0
TLS2_k127_252847_3 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000658 597.0
TLS2_k127_252847_4 Phosphomethylpyrimidine kinase K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 577.0
TLS2_k127_252847_5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009894 524.0
TLS2_k127_252847_6 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000076 507.0
TLS2_k127_252847_7 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 413.0
TLS2_k127_252847_8 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 409.0
TLS2_k127_252847_9 RNA methylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 377.0
TLS2_k127_2647495_0 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 411.0
TLS2_k127_2647495_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000005436 221.0
TLS2_k127_2647495_2 - - - - 0.00000000000000000000000000000000000000000000000000000001848 199.0
TLS2_k127_2647495_3 - - - - 0.000000000000000000000000000000000007985 137.0
TLS2_k127_2647495_5 Transposase, IS605 OrfB family K07496 - - 0.0008791 47.0
TLS2_k127_271001_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 2.264e-299 920.0
TLS2_k127_271001_1 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 343.0
TLS2_k127_271001_2 hydrolase (HAD superfamily) K01091,K01560,K01561,K07025 - 3.1.3.18,3.8.1.2,3.8.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 310.0
TLS2_k127_271001_3 - - - - 0.00000000000000000000000000000000000000000000000000009554 199.0
TLS2_k127_271001_4 - - - - 0.000000000000000000000000000000000000000001103 159.0
TLS2_k127_2725438_0 fumarate reductase flavoprotein K00239 - 1.3.5.1,1.3.5.4 0.0 1073.0
TLS2_k127_2725438_1 Cytochrome b subunit of the bc complex K00412 - - 1.734e-296 914.0
TLS2_k127_2725438_10 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.000000000000000000000000000000000000000000000000000000006157 202.0
TLS2_k127_2725438_11 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.00000000000000000000000000000000000000000000000000004825 191.0
TLS2_k127_2725438_12 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.0000000000000000000000000000000000000000000003448 169.0
TLS2_k127_2725438_13 lysine biosynthesis protein LysW K05826 - - 0.00000000000000000000000000144 111.0
TLS2_k127_2725438_15 - - - - 0.000000000000000000001167 95.0
TLS2_k127_2725438_16 PFAM Rieske 2Fe-2S domain K15878 - - 0.0000000001325 70.0
TLS2_k127_2725438_17 Transposase, is605 orfb family K07496 - - 0.0009687 42.0
TLS2_k127_2725438_2 HMGL-like K01649 - 2.3.3.13 9.568e-248 767.0
TLS2_k127_2725438_3 argininosuccinate lyase K01755 - 4.3.2.1 2.34e-221 695.0
TLS2_k127_2725438_4 Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine K05831 - - 1.349e-220 687.0
TLS2_k127_2725438_5 diphthine synthase K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 544.0
TLS2_k127_2725438_6 Lysine biosynthesis K05827 - 6.3.2.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 488.0
TLS2_k127_2725438_7 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 486.0
TLS2_k127_2725438_8 low-complexity proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000005068 223.0
TLS2_k127_2725438_9 Iron-sulfur cluster assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000004969 203.0
TLS2_k127_2751081_0 MGS-like domain K01955 - 6.3.5.5 0.0 1819.0
TLS2_k127_2751081_1 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.0 1027.0
TLS2_k127_2751081_10 Calcineurin-like phosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009517 343.0
TLS2_k127_2751081_11 acetolactate synthase, small K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 284.0
TLS2_k127_2751081_12 Transcriptional regulator K07108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002558 254.0
TLS2_k127_2751081_13 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000000000000008797 209.0
TLS2_k127_2751081_14 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000008614 200.0
TLS2_k127_2751081_15 restriction endonuclease K07448 - - 0.00000000000000000000000000000001751 130.0
TLS2_k127_2751081_16 - - - - 0.000000000000000000000000001203 115.0
TLS2_k127_2751081_2 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.017e-287 888.0
TLS2_k127_2751081_3 carbamoyl-phosphate synthase, small subunit K01956 - 6.3.5.5 8.37e-210 658.0
TLS2_k127_2751081_4 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 595.0
TLS2_k127_2751081_5 Isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 549.0
TLS2_k127_2751081_6 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 515.0
TLS2_k127_2751081_7 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 501.0
TLS2_k127_2751081_8 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006428 474.0
TLS2_k127_2751081_9 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 459.0
TLS2_k127_2751130_0 Methionine synthase K00548 - 2.1.1.13 0.0 1410.0
TLS2_k127_2751130_1 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 436.0
TLS2_k127_2751130_2 cytochrome-c peroxidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009875 351.0
TLS2_k127_2751130_3 - - - - 0.00000000000000000000000000000000000000000008161 166.0
TLS2_k127_2857937_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 3.735e-199 623.0
TLS2_k127_2857937_1 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006363 512.0
TLS2_k127_2857937_2 AMMECR1 K09141 - - 0.0000000000000000000000000000000000000000000000000000000000000000038 231.0
TLS2_k127_2857937_3 Translation initiation factor 2, alpha subunit K03237 - - 0.00000000000000000000000003061 108.0
TLS2_k127_2857937_4 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.0000000000000000000009691 96.0
TLS2_k127_2857937_6 Glycosyl transferase family 1 - - - 0.00000000001052 66.0
TLS2_k127_2867056_0 Sulfite reductase K00392 - 1.8.7.1 0.0 1085.0
TLS2_k127_2867056_1 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 532.0
TLS2_k127_2867056_10 TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000001549 241.0
TLS2_k127_2867056_12 COG0346 Lactoylglutathione lyase and related lyases K07032 - - 0.000000000000000000000000000000000000000000000000000000000000000009594 228.0
TLS2_k127_2867056_13 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000001192 241.0
TLS2_k127_2867056_14 Belongs to the UPF0201 family K09736 - - 0.000000000000000000000000000000000000000000000000000000000002752 211.0
TLS2_k127_2867056_15 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000005108 183.0
TLS2_k127_2867056_16 - - - - 0.00000000000000000000001592 101.0
TLS2_k127_2867056_17 - - - - 0.000000000000000000006986 92.0
TLS2_k127_2867056_18 HicA toxin of bacterial toxin-antitoxin, K07339 - - 0.0000002563 53.0
TLS2_k127_2867056_19 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00005907 49.0
TLS2_k127_2867056_2 Serine aminopeptidase, S33 K00433 - 1.11.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 464.0
TLS2_k127_2867056_3 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 451.0
TLS2_k127_2867056_4 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 445.0
TLS2_k127_2867056_5 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 384.0
TLS2_k127_2867056_6 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 311.0
TLS2_k127_2867056_7 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 313.0
TLS2_k127_2867056_8 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 285.0
TLS2_k127_2867056_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008238 245.0
TLS2_k127_2872177_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0 1252.0
TLS2_k127_2872177_1 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007366 421.0
TLS2_k127_2872177_2 Transposase, is605 orfb family K07496 - - 0.00009277 45.0
TLS2_k127_2892467_0 NADH ubiquinone oxidoreductase subunit 2 (Chain N) K22169 - 1.5.98.3 1.234e-284 879.0
TLS2_k127_2892467_1 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 484.0
TLS2_k127_2892467_10 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette K15342 - - 0.00001663 48.0
TLS2_k127_2892467_11 - - - - 0.0003365 45.0
TLS2_k127_2892467_2 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003945 481.0
TLS2_k127_2892467_3 Iron-containing redox enzyme K06137 - 1.3.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 342.0
TLS2_k127_2892467_4 Antibiotic biosynthesis monooxygenase K09932 - - 0.0000000000000000000000000000000000000000000000000000000000001338 217.0
TLS2_k127_2892467_5 WD40-like Beta Propeller Repeat K03641 - - 0.000000000000000000000000000000000000000000000000007236 199.0
TLS2_k127_2959596_0 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 9.464e-199 625.0
TLS2_k127_2959596_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 604.0
TLS2_k127_2959596_10 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000113 128.0
TLS2_k127_2959596_2 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 579.0
TLS2_k127_2959596_3 Arsenite-activated ATPase ArsA K01551,K13993 - 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 552.0
TLS2_k127_2959596_4 Glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006102 529.0
TLS2_k127_2959596_5 CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 507.0
TLS2_k127_2959596_6 PFAM 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 366.0
TLS2_k127_2963214_0 Belongs to the MCM family K10726 - - 0.0 1247.0
TLS2_k127_2963214_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.0 1106.0
TLS2_k127_2963214_10 GINS complex protein K09723 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005961 264.0
TLS2_k127_2963214_11 Lamin Tail Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003994 269.0
TLS2_k127_2963214_12 Cytidylyltransferase-like K00952 - 2.7.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000007957 249.0
TLS2_k127_2963214_14 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000008374 179.0
TLS2_k127_2963214_16 - - - - 0.00000000000000000008001 89.0
TLS2_k127_2963214_17 - - - - 0.000000000000000001084 88.0
TLS2_k127_2963214_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 8.74e-317 981.0
TLS2_k127_2963214_3 COG0433 Predicted ATPase K06915 - - 1.471e-275 851.0
TLS2_k127_2963214_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 595.0
TLS2_k127_2963214_5 PFAM NurA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 537.0
TLS2_k127_2963214_6 glycosyl transferase family K01001 - 2.7.8.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 505.0
TLS2_k127_2963214_7 Replication factor C K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005237 352.0
TLS2_k127_2980016_0 Tetrapyrrole (Corrin/Porphyrin) Methylases K05934 - 2.1.1.131 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 503.0
TLS2_k127_2980016_1 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 421.0
TLS2_k127_2980016_12 - - - - 0.000000003788 66.0
TLS2_k127_2980016_13 - - - - 0.0003415 49.0
TLS2_k127_2980016_14 beta-galactosidase activity - - - 0.0005214 50.0
TLS2_k127_2980016_2 NADPH-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001853 266.0
TLS2_k127_2980016_3 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003161 266.0
TLS2_k127_2980016_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000002439 218.0
TLS2_k127_2980016_5 protocatechuate 3,4-dioxygenase - - - 0.000000000000000000000000000000000000000000000000000002443 211.0
TLS2_k127_2980016_6 PRC-barrel domain protein - - - 0.0000000000000000000000000000000000005819 144.0
TLS2_k127_2980016_7 Spherulation-specific family 4 - - - 0.0000000000000000000000000005325 127.0
TLS2_k127_2980016_8 Transcriptional regulator - - - 0.00000000000000000000000002365 110.0
TLS2_k127_2980016_9 - - - - 0.0000000000000000000000002071 113.0
TLS2_k127_3009757_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1521.0
TLS2_k127_3009757_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 2.068e-308 957.0
TLS2_k127_3009757_10 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.000000000000000000000000000000000000000000000000000000000001222 216.0
TLS2_k127_3009757_11 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02259 - - 0.000000000000000000000000000000000000000000000000001297 186.0
TLS2_k127_3009757_12 response regulator, receiver - - - 0.00000000000000000000000000000000000000000007043 162.0
TLS2_k127_3009757_13 Transcriptional regulator K07731 - - 0.00000000000000000000000000000000000003889 149.0
TLS2_k127_3009757_14 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.0000000000000000000000003887 110.0
TLS2_k127_3009757_15 - - - - 0.00000000000000000000000173 102.0
TLS2_k127_3009757_16 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000000000000000000000391 105.0
TLS2_k127_3009757_2 Anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 2.706e-306 951.0
TLS2_k127_3009757_3 Thiolase, N-terminal domain K00626 - 2.3.1.9 4.15e-236 732.0
TLS2_k127_3009757_4 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 456.0
TLS2_k127_3009757_5 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 424.0
TLS2_k127_3009757_6 Carbon-nitrogen hydrolase K11206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007603 394.0
TLS2_k127_3009757_7 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 355.0
TLS2_k127_3009757_8 conserved protein implicated in secretion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002716 277.0
TLS2_k127_3009757_9 UreE urease accessory protein, C-terminal domain K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004273 270.0
TLS2_k127_3031279_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1122.0
TLS2_k127_3031279_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1101.0
TLS2_k127_3031279_10 Pyridoxamine 5'-phosphate K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000914 304.0
TLS2_k127_3031279_11 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006325 270.0
TLS2_k127_3031279_12 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000000887 218.0
TLS2_k127_3031279_14 Transcriptional regulator - - - 0.000000000000000000000000000000000000001306 149.0
TLS2_k127_3031279_17 Transcriptional regulator - - - 0.00000000000000000000000000000006594 126.0
TLS2_k127_3031279_18 Probable cobalt transporter subunit (CbtB) - - - 0.000000000000000000000000006167 110.0
TLS2_k127_3031279_19 - - - - 0.0000000000000000001539 92.0
TLS2_k127_3031279_2 TIGRFAM excinuclease ABC, C subunit K03703 - - 8.32e-262 817.0
TLS2_k127_3031279_21 Transposase, is605 orfb family K07496 - - 0.0007843 43.0
TLS2_k127_3031279_3 Radical SAM K11781 - 2.5.1.77 1.142e-235 732.0
TLS2_k127_3031279_4 Radical SAM K11780 - 2.5.1.77 9.814e-198 621.0
TLS2_k127_3031279_5 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 588.0
TLS2_k127_3031279_6 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 584.0
TLS2_k127_3031279_7 PFAM Alanine dehydrogenase PNT K00259,K00324 GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1,1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 490.0
TLS2_k127_3031279_8 TIGRFAM phosphate ABC transporter K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 454.0
TLS2_k127_3031279_9 Probable cobalt transporter subunit (CbtA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 311.0
TLS2_k127_3083666_0 Catalyzes the conversion of dihydroorotate to orotate K00226,K00254,K17723,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 556.0
TLS2_k127_3083666_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 455.0
TLS2_k127_3083666_2 Sugar efflux transporter for intercellular exchange K15383 - - 0.000000000000000000000000000000000003223 139.0
TLS2_k127_3102156_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K00313 - - 0.0 1034.0
TLS2_k127_3102156_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 1.216e-230 721.0
TLS2_k127_3102156_11 Belongs to the ribosomal protein L31e family K02910 - - 0.0000000000000000000000000000000000000000000000001413 180.0
TLS2_k127_3102156_14 - - - - 0.00000000000000000000000001007 110.0
TLS2_k127_3102156_15 Belongs to the eukaryotic ribosomal protein eL39 family K02924 - - 0.0000000000000000000001039 98.0
TLS2_k127_3102156_16 - - - - 0.0000000000000000000001169 98.0
TLS2_k127_3102156_17 - - - - 0.00000000000000003302 82.0
TLS2_k127_3102156_2 MiaB-like tRNA modifying enzyme K15865 - 2.8.4.5 1.461e-216 679.0
TLS2_k127_3102156_3 Electron transfer flavoprotein domain K03522 - - 1.78e-203 639.0
TLS2_k127_3102156_4 Electron transfer flavoprotein domain K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000682 499.0
TLS2_k127_3102156_5 DHHA1 domain K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 484.0
TLS2_k127_3102156_6 Tubulin/FtsZ family, GTPase domain K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007361 447.0
TLS2_k127_3102156_7 Redoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 326.0
TLS2_k127_3102156_8 HD domain K00951,K01139 - 2.7.6.5,3.1.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000978 326.0
TLS2_k127_3102156_9 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001734 246.0
TLS2_k127_3111825_0 Sodium:solute symporter family - - - 7.89e-250 781.0
TLS2_k127_3111825_1 Belongs to the arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 528.0
TLS2_k127_3111825_2 TIGRFAM ParB RepB Spo0J family partition protein K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 399.0
TLS2_k127_3111825_3 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004276 357.0
TLS2_k127_3111825_4 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03190 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 315.0
TLS2_k127_3111825_6 UreF K03188 - - 0.0000000000000000000000000000000000000000000000000000000000000000001407 237.0
TLS2_k127_3111825_7 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K03294,K20989 - - 0.0000000000000000000000000000000000000000000000000000000000000001311 224.0
TLS2_k127_3111825_9 UreE urease accessory protein, N-terminal domain K03187 - - 0.0000000000000000000000000000000000006585 145.0
TLS2_k127_3182185_0 Type III restriction enzyme, res subunit - - - 4.357e-205 646.0
TLS2_k127_3182185_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family - GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016427,GO:0016428,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005593 419.0
TLS2_k127_3182185_10 - - - - 0.00000000000000000000000000002101 126.0
TLS2_k127_3182185_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 359.0
TLS2_k127_3182185_3 Predicted membrane protein (DUF2070) K08979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006444 356.0
TLS2_k127_3182185_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007033 360.0
TLS2_k127_3182185_5 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 326.0
TLS2_k127_3182185_6 Ribosome biogenesis protein, C-terminal K09140 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 282.0
TLS2_k127_3182185_7 Guanylyl transferase CofC like K14941 - 2.7.7.68 0.000000000000000000000000000000000000000000000000000000000007864 214.0
TLS2_k127_3182185_8 Protein involved in ribosomal biogenesis, contains PUA domain K07565 - - 0.00000000000000000000000000000000000000000000000005452 183.0
TLS2_k127_3212049_0 synthetase (class II) K01880 - 6.1.1.14 4.638e-288 887.0
TLS2_k127_3212049_1 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 5.153e-228 709.0
TLS2_k127_3212049_10 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000006656 144.0
TLS2_k127_3212049_11 - - - - 0.0000000000000000000000000000000001129 139.0
TLS2_k127_3212049_12 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000001662 128.0
TLS2_k127_3212049_13 - - - - 0.000000000000000000000000000003713 122.0
TLS2_k127_3212049_14 UbiA prenyltransferase family K03179 - 2.5.1.39 0.000000000000000000000000000008536 130.0
TLS2_k127_3212049_15 Transcriptional regulator - - - 0.0000000000000000000003781 98.0
TLS2_k127_3212049_16 Thioredoxin - - - 0.000000000000000000117 93.0
TLS2_k127_3212049_17 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000007105 74.0
TLS2_k127_3212049_18 His Kinase A (phosphoacceptor) domain - - - 0.0000000408 59.0
TLS2_k127_3212049_2 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004398 478.0
TLS2_k127_3212049_3 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009963 357.0
TLS2_k127_3212049_4 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 311.0
TLS2_k127_3212049_5 PFAM Methyltransferase type K15256 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007351 299.0
TLS2_k127_3212049_6 PFAM TatD-related deoxyribonuclease K07051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002325 274.0
TLS2_k127_3212049_7 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000474 264.0
TLS2_k127_3212049_8 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000009953 243.0
TLS2_k127_3229714_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1151.0
TLS2_k127_3229714_1 4Fe-4S single cluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000895 603.0
TLS2_k127_3229714_2 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 315.0
TLS2_k127_3229714_6 ABC-2 family transporter protein K01992 - - 0.0000001457 57.0
TLS2_k127_3250179_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 1.103e-210 661.0
TLS2_k127_3250179_1 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 522.0
TLS2_k127_3250179_10 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 299.0
TLS2_k127_3250179_11 Binds to the 23S rRNA K02885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002371 251.0
TLS2_k127_3250179_12 ribosomal protein K02912 - - 0.00000000000000000000000000000000000000000000000000000000000000000000517 237.0
TLS2_k127_3250179_14 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000002356 163.0
TLS2_k127_3250179_15 Domain of unknown function (DUF309) K09763 - - 0.000000000000000000000000000000000000000004667 161.0
TLS2_k127_3250179_16 - - - - 0.00000000000000000000000000000000000006601 143.0
TLS2_k127_3250179_17 - - - - 0.000000000000000000004871 92.0
TLS2_k127_3250179_18 - - - - 0.0000000000000000004273 87.0
TLS2_k127_3250179_2 serine-type endopeptidase activity K00505,K01342,K02035 - 1.14.18.1,3.4.21.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 477.0
TLS2_k127_3250179_3 elongation factor Tu - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005605 428.0
TLS2_k127_3250179_4 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 395.0
TLS2_k127_3250179_5 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009533 389.0
TLS2_k127_3250179_6 Ribose-phosphate pyrophosphokinase K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 380.0
TLS2_k127_3250179_7 Siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009218 363.0
TLS2_k127_3250179_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 356.0
TLS2_k127_3250179_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 311.0
TLS2_k127_3304400_0 Belongs to the RtcB family K14415 - 6.5.1.3 1.969e-274 847.0
TLS2_k127_3304400_1 PFAM tRNA synthetase, class II (D, K and N) K01893 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 3.871e-250 775.0
TLS2_k127_3304400_10 Located on the platform of the 30S subunit K02948 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002806 256.0
TLS2_k127_3304400_11 Chlorophyllase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000247 254.0
TLS2_k127_3304400_12 - - - - 0.00000000000000000000000000000000000000000000001047 176.0
TLS2_k127_3304400_14 - - - - 0.000000000000000000000000000000000000000001632 158.0
TLS2_k127_3304400_15 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000001866 162.0
TLS2_k127_3304400_16 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000002401 145.0
TLS2_k127_3304400_17 - - - - 0.000000000000000000000000000000001598 145.0
TLS2_k127_3304400_19 - - - - 0.0000000000000000000000001487 109.0
TLS2_k127_3304400_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 590.0
TLS2_k127_3304400_22 - - - - 0.000001777 55.0
TLS2_k127_3304400_3 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 560.0
TLS2_k127_3304400_4 homocysteine S-methyltransferase K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 547.0
TLS2_k127_3304400_5 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 440.0
TLS2_k127_3304400_7 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 287.0
TLS2_k127_3304400_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009015 283.0
TLS2_k127_3307962_0 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 533.0
TLS2_k127_3307962_1 phosphoribosylglycinamide formyltransferase K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 346.0
TLS2_k127_3307962_2 Luciferase-like monooxygenase K14728 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008644 305.0
TLS2_k127_3307962_3 major facilitator superfamily K08153,K08221 - - 0.000000000000000000000000000000000000000000000000000000000000000000001609 240.0
TLS2_k127_3311946_0 DNA polymerase K02319 - 2.7.7.7 0.0 1268.0
TLS2_k127_3311946_1 AAA domain K03546 - - 3.205e-307 955.0
TLS2_k127_3311946_10 Lon protease (S16) C-terminal proteolytic domain - - - 0.000000000003007 78.0
TLS2_k127_3311946_12 - - - - 0.00000008695 57.0
TLS2_k127_3311946_2 FAD dependent oxidoreductase K15736 - - 8.39e-220 687.0
TLS2_k127_3311946_3 Domain of unknown function DUF87 K06915 - - 8.668e-216 680.0
TLS2_k127_3311946_4 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000998 539.0
TLS2_k127_3311946_5 Belongs to the arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 457.0
TLS2_k127_3311946_7 - - - - 0.000000000000000000000000000001511 125.0
TLS2_k127_3311946_8 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000007881 126.0
TLS2_k127_3336944_0 FeS assembly protein SufB K09014 - - 1.469e-300 924.0
TLS2_k127_3336944_1 FeS assembly protein SufD K09014,K09015 - - 1.202e-243 758.0
TLS2_k127_3336944_11 Nudix hydrolase K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000007477 213.0
TLS2_k127_3336944_12 Putative tRNA binding domain K06878 - - 0.0000000000000000000000000000000000000000000000000001327 187.0
TLS2_k127_3336944_13 - - - - 0.000000000000000000000000000000000000000000000000000389 186.0
TLS2_k127_3336944_15 of nitrite reductase and ring-hydroxylating K05710 - - 0.000000000000000000000000000000000000000009621 156.0
TLS2_k127_3336944_16 Transcriptional regulator K11924 - - 0.000000000000000000000000002829 113.0
TLS2_k127_3336944_17 Transposase, is605 orfb family K07496 - - 0.00000000000000007992 81.0
TLS2_k127_3336944_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 4.482e-241 749.0
TLS2_k127_3336944_3 cation diffusion facilitator family transporter - - - 1.563e-206 651.0
TLS2_k127_3336944_4 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004471 558.0
TLS2_k127_3336944_5 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 465.0
TLS2_k127_3336944_6 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008084 385.0
TLS2_k127_3336944_7 protein (ATP-grasp superfamily) K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 364.0
TLS2_k127_3336944_8 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006768 305.0
TLS2_k127_3336944_9 SUF system FeS assembly protein K04488 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001483 269.0
TLS2_k127_3354877_0 TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit K03821 - - 1.4e-203 637.0
TLS2_k127_3354877_1 Sodium hydrogen exchanger K03455 - - 7.171e-198 622.0
TLS2_k127_3354877_10 transcription factor (CBF NF-Y) - - - 0.0000000000000000000000003624 106.0
TLS2_k127_3354877_11 Kinase binding protein CGI-121 - - - 0.000000000000000000000001506 105.0
TLS2_k127_3354877_2 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 369.0
TLS2_k127_3354877_3 PFAM D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 336.0
TLS2_k127_3354877_4 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004961 261.0
TLS2_k127_3354877_5 Sua5 YciO YrdC YwlC family K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000002716 240.0
TLS2_k127_3354877_6 Kinase binding protein CGI-121 - - - 0.0000000000000000000000000000000000000000000000000000155 193.0
TLS2_k127_3354877_7 - - - - 0.000000000000000000000000000000000000000002786 160.0
TLS2_k127_3354877_8 THUMP domain K06963 - - 0.0000000000000000000000000000000000000006438 154.0
TLS2_k127_3354877_9 ribosomal protein K02962 - - 0.00000000000000000000000000003489 118.0
TLS2_k127_3387089_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 9.084e-310 974.0
TLS2_k127_3387089_1 PD-(D/E)XK nuclease superfamily K03657 - 3.6.4.12 9.422e-237 770.0
TLS2_k127_3387089_10 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.0000000000000000000000000000001276 130.0
TLS2_k127_3387089_11 COG0589 Universal stress protein UspA and related nucleotide-binding - - - 0.00000000000000005967 87.0
TLS2_k127_3387089_12 PFAM CBS domain containing protein - - - 0.0000000000000002906 86.0
TLS2_k127_3387089_13 PFAM blue (type 1) copper domain protein - - - 0.000000000001028 79.0
TLS2_k127_3387089_14 AMP binding K03499,K06149 - - 0.00000002962 61.0
TLS2_k127_3387089_16 PFAM blue (type 1) copper domain protein - - - 0.00002906 52.0
TLS2_k127_3387089_17 Transposase, is605 orfb family K07496 - - 0.0004185 44.0
TLS2_k127_3387089_18 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0006003 48.0
TLS2_k127_3387089_2 Na+-dependent bicarbonate transporter superfamily K07086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 456.0
TLS2_k127_3387089_3 Transposase, is605 orfb family K07496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 399.0
TLS2_k127_3387089_4 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 333.0
TLS2_k127_3387089_5 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 334.0
TLS2_k127_3387089_6 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005032 324.0
TLS2_k127_3387089_8 Nitrogen regulatory protein P-II - - - 0.000000000000000000000000000000002031 131.0
TLS2_k127_3387089_9 signal transduction histidine kinase - - - 0.00000000000000000000000000000006195 137.0
TLS2_k127_3513905_0 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000007923 211.0
TLS2_k127_3513905_1 - - - - 0.0000000000000000000000000000000001697 142.0
TLS2_k127_3513905_3 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.00000000000000000000002024 100.0
TLS2_k127_3513905_4 - - - - 0.00000000000000006381 86.0
TLS2_k127_3513905_5 - - - - 0.000001604 55.0
TLS2_k127_3599520_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 615.0
TLS2_k127_3599520_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 409.0
TLS2_k127_3599520_4 Nitroreductase - - - 0.0000000000000000000008686 96.0
TLS2_k127_3599520_5 Nitroreductase - - - 0.0000000000122 66.0
TLS2_k127_3606124_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1887.0
TLS2_k127_3606124_1 ThiF family K21029 - 2.7.7.80 3.186e-247 767.0
TLS2_k127_3606124_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000008747 225.0
TLS2_k127_3606124_11 Ribonuclease K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000001233 216.0
TLS2_k127_3606124_12 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000000000000000000416 211.0
TLS2_k127_3606124_13 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000005462 203.0
TLS2_k127_3606124_16 - - - - 0.00000000000000000000000000000000000009586 145.0
TLS2_k127_3606124_17 NADH ubiquinone oxidoreductase - - - 0.00000000000000000000000000000003028 124.0
TLS2_k127_3606124_18 low molecular weight K03741 - 1.20.4.1 0.00000000000000000000000000003375 123.0
TLS2_k127_3606124_19 thymidylate kinase K00943 - 2.7.4.9 0.00000002666 55.0
TLS2_k127_3606124_2 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 1.584e-236 735.0
TLS2_k127_3606124_3 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 1.285e-216 683.0
TLS2_k127_3606124_4 Sodium hydrogen exchanger K03455 - - 2.115e-194 614.0
TLS2_k127_3606124_5 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 548.0
TLS2_k127_3606124_6 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 393.0
TLS2_k127_3606124_7 Methyltransferase type 11 K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 360.0
TLS2_k127_3606124_8 Major Intrinsic Protein K06188 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004978 289.0
TLS2_k127_3606124_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002263 253.0
TLS2_k127_3657551_0 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 552.0
TLS2_k127_3657551_1 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008688 517.0
TLS2_k127_3657551_2 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000632 373.0
TLS2_k127_3657551_3 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005395 292.0
TLS2_k127_3657551_4 - - - - 0.000000000000000000000000000001945 127.0
TLS2_k127_3665174_2 PFAM Zn-finger in ubiquitin-hydrolases and other protein - - - 0.00000000000000000000002233 101.0
TLS2_k127_3665174_3 Transposase, is605 orfb family K07496 - - 0.000005756 52.0
TLS2_k127_3665174_4 Spherulation-specific family 4 - - - 0.00002959 54.0
TLS2_k127_3665244_0 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 471.0
TLS2_k127_3665244_1 CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003175 257.0
TLS2_k127_3665244_10 - - - - 0.0000001086 55.0
TLS2_k127_3665244_2 dimethylhistidine N-methyltransferase activity K18911 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008213,GO:0008276,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0019439,GO:0019538,GO:0019752,GO:0032259,GO:0034641,GO:0036211,GO:0042398,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052707,GO:0052708,GO:0052709,GO:0052803,GO:0052805,GO:0071704,GO:0071944,GO:0097164,GO:0140096,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000001004 259.0
TLS2_k127_3665244_4 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000000000000000000000000000000000003446 147.0
TLS2_k127_3665244_5 PFAM Alcohol dehydrogenase GroES-like domain K00001,K13953,K18382 - 1.1.1.1 0.0000000000000000000000000000000000002035 143.0
TLS2_k127_3665244_6 PFAM Alcohol dehydrogenase GroES-like domain K00001,K13953,K18382 - 1.1.1.1 0.0000000000000000000000000000188 121.0
TLS2_k127_3665244_7 PFAM Alcohol dehydrogenase GroES-like domain K00001,K13953,K18382 - 1.1.1.1 0.00000000000000000000000000003661 120.0
TLS2_k127_3665244_9 membrane protein domain - - - 0.0000000342 56.0
TLS2_k127_3667996_0 Amino acid kinase family K00928 - 2.7.2.4 1.666e-259 804.0
TLS2_k127_3667996_1 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 1.886e-234 736.0
TLS2_k127_3667996_10 thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 403.0
TLS2_k127_3667996_11 PhoU domain K02039 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003888 374.0
TLS2_k127_3667996_12 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006228 356.0
TLS2_k127_3667996_13 Periplasmic solute binding protein K09815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007601 346.0
TLS2_k127_3667996_14 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005469 341.0
TLS2_k127_3667996_15 PFAM ABC transporter K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 338.0
TLS2_k127_3667996_16 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000003225 256.0
TLS2_k127_3667996_17 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000002297 236.0
TLS2_k127_3667996_18 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.00000000000000000000000000000000000000000000000000000000000002794 218.0
TLS2_k127_3667996_2 methylase K00590 - 2.1.1.113 1.725e-205 644.0
TLS2_k127_3667996_20 Ribbon-helix-helix protein, copG family K07722 - - 0.0000000000000000000000000000000000000000000000006483 177.0
TLS2_k127_3667996_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 515.0
TLS2_k127_3667996_4 Glycosyltransferase family 28 C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004461 495.0
TLS2_k127_3667996_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 483.0
TLS2_k127_3667996_6 TIGRFAM phosphate ABC transporter K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 463.0
TLS2_k127_3667996_7 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 467.0
TLS2_k127_3667996_8 TIGRFAM phosphate ABC transporter K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007491 447.0
TLS2_k127_3667996_9 thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009573 401.0
TLS2_k127_3672009_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.24e-322 992.0
TLS2_k127_3672009_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 3.763e-273 842.0
TLS2_k127_3672009_10 resolvase K14060 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 349.0
TLS2_k127_3672009_11 8-amino-7-oxononanoate synthase K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008815 323.0
TLS2_k127_3672009_12 tRNA intron endonuclease, N-terminal domain K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 310.0
TLS2_k127_3672009_13 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000834 306.0
TLS2_k127_3672009_14 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 293.0
TLS2_k127_3672009_16 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003943 258.0
TLS2_k127_3672009_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003538 242.0
TLS2_k127_3672009_18 HIT domain K02503 - - 0.0000000000000000000000000000000000000000000000000000000000000006532 221.0
TLS2_k127_3672009_19 - - - - 0.000000000000000000000000000000000000000000000000000000000002281 213.0
TLS2_k127_3672009_2 component I K01657 - 4.1.3.27 2.345e-228 713.0
TLS2_k127_3672009_20 - - - - 0.000000000000000000000000000000000000000000000000000000001077 202.0
TLS2_k127_3672009_21 - - - - 0.000000000000000000000000000000000000000000000002402 175.0
TLS2_k127_3672009_22 - - - - 0.000000000000000000000000000000000000004061 149.0
TLS2_k127_3672009_23 - - - - 0.0000000000000000000000000000000000002364 144.0
TLS2_k127_3672009_25 ribosomal protein S14 K02954 - - 0.00000000000000000000000000001303 117.0
TLS2_k127_3672009_26 Radical SAM - - - 0.00000000000000000000000007928 107.0
TLS2_k127_3672009_28 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.000000001809 63.0
TLS2_k127_3672009_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 4.52e-226 706.0
TLS2_k127_3672009_4 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 569.0
TLS2_k127_3672009_5 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 548.0
TLS2_k127_3672009_6 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003497 472.0
TLS2_k127_3672009_7 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 409.0
TLS2_k127_3672009_8 conserved protein implicated in secretion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005958 372.0
TLS2_k127_3672009_9 Protein of unknown function DUF47 K07220 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007018 361.0
TLS2_k127_3724901_0 ATP synthase (C/AC39) subunit K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 580.0
TLS2_k127_3724901_1 methylase K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 479.0
TLS2_k127_3724901_10 Transposase, is605 orfb family K07496 - - 0.00001271 48.0
TLS2_k127_3724901_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 445.0
TLS2_k127_3724901_4 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K00595,K02006,K02191 - 2.1.1.132,2.1.1.196 0.0000000000000000000000000000000000000000347 158.0
TLS2_k127_3724901_5 - - - - 0.000000000000000000000000000000000009825 138.0
TLS2_k127_3724901_7 - - - - 0.000000000000000000000001299 108.0
TLS2_k127_3724901_8 COG1522 Transcriptional regulators - - - 0.0000000000007626 74.0
TLS2_k127_3765235_0 Peptidase family M3 K08602 - - 1.868e-307 950.0
TLS2_k127_3765235_1 PFAM Alcohol dehydrogenase GroES-like domain - - - 2.25e-220 685.0
TLS2_k127_3765235_10 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 GO:0003674,GO:0003824,GO:0004766,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0043919,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0050314,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 344.0
TLS2_k127_3765235_11 PFAM DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 313.0
TLS2_k127_3765235_12 Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA K14568 - 2.1.1.260 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 311.0
TLS2_k127_3765235_13 Lrp/AsnC ligand binding domain K03718 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005581 286.0
TLS2_k127_3765235_14 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001261 276.0
TLS2_k127_3765235_15 Na -dependent transporter K03453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000929 278.0
TLS2_k127_3765235_16 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000000000000001462 203.0
TLS2_k127_3765235_17 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.00000000000000000000000000000000001147 139.0
TLS2_k127_3765235_18 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000000000008651 125.0
TLS2_k127_3765235_19 DUF167 K09131 - - 0.000000000000000004824 86.0
TLS2_k127_3765235_2 aspartate-semialdehyde dehydrogenase K00133 - 1.2.1.11 4.733e-202 634.0
TLS2_k127_3765235_20 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.000000000002118 71.0
TLS2_k127_3765235_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003062 520.0
TLS2_k127_3765235_4 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 492.0
TLS2_k127_3765235_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 490.0
TLS2_k127_3765235_6 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 473.0
TLS2_k127_3765235_7 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006096 458.0
TLS2_k127_3765235_8 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 419.0
TLS2_k127_3765235_9 protein with SCP PR1 domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 416.0
TLS2_k127_3766294_0 3-isopropylmalate dehydratase, large subunit K01703 - 4.2.1.33,4.2.1.35 6.266e-271 838.0
TLS2_k127_3766294_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 4.089e-244 760.0
TLS2_k127_3766294_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006667 402.0
TLS2_k127_3766294_3 3-isopropylmalate dehydratase, small subunit K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006049 332.0
TLS2_k127_3766294_4 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) K05967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004864 304.0
TLS2_k127_3766294_5 - - - - 0.0000000000000000000000000000000002574 134.0
TLS2_k127_3766294_7 response regulator receiver - - - 0.0000000000003581 74.0
TLS2_k127_382157_0 4Fe-4S single cluster domain - - - 5.93e-206 641.0
TLS2_k127_382157_1 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 380.0
TLS2_k127_382157_2 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 GO:0003674,GO:0003824,GO:0004766,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0043919,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0050314,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 335.0
TLS2_k127_382157_3 COG2070 Dioxygenases related to 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 330.0
TLS2_k127_382157_4 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 290.0
TLS2_k127_382157_5 Lrp/AsnC ligand binding domain - - - 0.00000000000000000000000000000000000000000003473 161.0
TLS2_k127_3847204_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.0 1148.0
TLS2_k127_3847204_1 protein (ATP-grasp superfamily) K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 362.0
TLS2_k127_3847204_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008071 346.0
TLS2_k127_3847204_3 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004 267.0
TLS2_k127_3847204_4 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.000000000000000000000000000000000000000000005589 164.0
TLS2_k127_3847204_5 Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000000000006084 161.0
TLS2_k127_3931853_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01870 - 6.1.1.5 0.0 1906.0
TLS2_k127_3931853_1 PFAM TCP-1 cpn60 chaperonin family K22447 - - 2.47e-243 758.0
TLS2_k127_3931853_10 - - - - 0.000000000000000000000000000000000000000000000000000003091 192.0
TLS2_k127_3931853_11 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000000000000000000000000000000003349 195.0
TLS2_k127_3931853_13 Ser thr protein kinase K07176 - - 0.0000000000000000000000000000000000006063 143.0
TLS2_k127_3931853_14 - - - - 0.000000000000000000000202 96.0
TLS2_k127_3931853_2 AAA domain (Cdc48 subfamily) - - - 3.782e-240 744.0
TLS2_k127_3931853_3 transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 601.0
TLS2_k127_3931853_4 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 354.0
TLS2_k127_3931853_5 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 322.0
TLS2_k127_3931853_6 conserved protein implicated in secretion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 292.0
TLS2_k127_3931853_7 transcriptional K07721 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005396 252.0
TLS2_k127_3931853_8 Dual specificity phosphatase, catalytic domain K14165 - 3.1.3.16,3.1.3.48 0.00000000000000000000000000000000000000000000000000000000000000000000932 237.0
TLS2_k127_3951957_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1455.0
TLS2_k127_3951957_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 2.783e-251 781.0
TLS2_k127_3951957_2 Thioredoxin K03671 - - 0.00000000000000000000000000000000000000000000000000000000001745 207.0
TLS2_k127_3951957_4 Transposase, is605 orfb family K07496 - - 0.00000008713 57.0
TLS2_k127_3969087_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 5.248e-223 698.0
TLS2_k127_3969087_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 601.0
TLS2_k127_3969087_3 Polysaccharide deacetylase - - - 0.00000000000001543 86.0
TLS2_k127_3977310_0 Belongs to the arginase family K01476 - 3.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003945 386.0
TLS2_k127_3977310_1 PFAM Cupin 2, conserved barrel domain protein K11312 - - 0.00000000000000000000000000000000000000000000000000228 184.0
TLS2_k127_3977310_3 - - - - 0.00000000000000000000001263 104.0
TLS2_k127_3977310_4 Transcriptional regulator - - - 0.0000000000000000000006712 98.0
TLS2_k127_3977310_5 SurA N-terminal domain - - - 0.00000004169 63.0
TLS2_k127_3977310_6 COG3547 Transposase and inactivated derivatives - - - 0.000007018 51.0
TLS2_k127_4029125_0 Belongs to the peptidase M50B family - GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 438.0
TLS2_k127_4029125_1 poly(R)-hydroxyalkanoic acid synthase subunit PhaC K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003493 263.0
TLS2_k127_4029125_2 COG2406 Protein distantly related to bacterial ferritins K03594 - 1.16.3.1 0.0000000000000000000002633 97.0
TLS2_k127_4034654_0 Enoyl-(Acyl carrier protein) reductase - - - 7.236e-304 936.0
TLS2_k127_4034654_1 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 600.0
TLS2_k127_4034654_2 Mitochondrial biogenesis AIM24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 401.0
TLS2_k127_4034654_3 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008151 305.0
TLS2_k127_4034654_4 PUA domain K07575 - - 0.0000000000000000000000000000000000000000000000000000001979 197.0
TLS2_k127_4035540_0 Succinyl-CoA ligase like flavodoxin domain K18594 - - 0.0 1273.0
TLS2_k127_4035540_1 glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008475 262.0
TLS2_k127_4042022_0 Fumarase C C-terminus K01744 - 4.3.1.1 9.718e-260 805.0
TLS2_k127_4042022_1 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.146e-257 799.0
TLS2_k127_4042022_10 Ribosomal protein L15E K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 285.0
TLS2_k127_4042022_11 Functions by promoting the formation of the first peptide bond K03263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002765 249.0
TLS2_k127_4042022_12 helix_turn_helix ASNC type - - - 0.00000000000000000000000000000000000000000000000000000000000000000009036 232.0
TLS2_k127_4042022_13 - - - - 0.00000000000000000000000000000000000000000000000000001093 192.0
TLS2_k127_4042022_16 Domain of unknown function (DUF4342) - - - 0.0000000000004723 74.0
TLS2_k127_4042022_17 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K05830 - - 0.0000000000008375 69.0
TLS2_k127_4042022_19 Glycosyl transferase family group 2 - - - 0.0000000001778 72.0
TLS2_k127_4042022_2 PFAM Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 9.141e-197 616.0
TLS2_k127_4042022_3 inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 572.0
TLS2_k127_4042022_4 Mg2 transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 511.0
TLS2_k127_4042022_5 inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007403 504.0
TLS2_k127_4042022_6 Multicopper oxidase K00368 - 1.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 469.0
TLS2_k127_4042022_7 Delta-aminolevulinic acid dehydratase K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 396.0
TLS2_k127_4042022_8 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004484 370.0
TLS2_k127_4042022_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005436 331.0
TLS2_k127_4045785_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K01953,K06927 - 6.3.1.14,6.3.5.4 1.561e-228 719.0
TLS2_k127_4045785_1 Required for chromosome condensation and partitioning - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006597 361.0
TLS2_k127_4045785_10 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000000000000002038 108.0
TLS2_k127_4045785_12 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000004857 57.0
TLS2_k127_4045785_2 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008942 289.0
TLS2_k127_4045785_6 membrane - - - 0.0000000000000000000000000000000000000000000000000000004426 207.0
TLS2_k127_4045785_8 Cupin domain - - - 0.0000000000000000000000000000000000000000006097 159.0
TLS2_k127_4045785_9 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000006647 156.0
TLS2_k127_4058224_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 2.358e-310 952.0
TLS2_k127_4058224_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01581,K01586,K13747 - 4.1.1.17,4.1.1.20,4.1.1.96 5.416e-267 825.0
TLS2_k127_4058224_10 Transposase, is605 orfb family K07496 - - 0.000009884 51.0
TLS2_k127_4058224_2 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 476.0
TLS2_k127_4058224_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004306 468.0
TLS2_k127_4058224_4 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 451.0
TLS2_k127_4058224_5 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 352.0
TLS2_k127_4058224_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 340.0
TLS2_k127_4058224_7 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 336.0
TLS2_k127_4058224_8 - - - - 0.000000000000000000000000000000006094 130.0
TLS2_k127_4058224_9 Acylphosphatase K01512 - 3.6.1.7 0.0000000000000000000000000000001481 125.0
TLS2_k127_4089099_0 PFAM aminotransferase class-III K01845 - 5.4.3.8 5.803e-224 699.0
TLS2_k127_4089099_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 503.0
TLS2_k127_4089099_2 Belongs to the precorrin methyltransferase family K02303 - 2.1.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 299.0
TLS2_k127_4089099_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004304 290.0
TLS2_k127_4089099_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008624 245.0
TLS2_k127_4089099_5 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.000000000000000000000000001803 115.0
TLS2_k127_4098151_0 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 2.195e-213 671.0
TLS2_k127_4098151_1 tRNA pseudouridine synthase K06176 - 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 584.0
TLS2_k127_4098151_10 Transposase, is605 orfb family K07496 - - 0.000000000000000000000716 96.0
TLS2_k127_4098151_11 Response regulator containing CheY-like receiver and SARP domains - - - 0.000000000379 63.0
TLS2_k127_4098151_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 404.0
TLS2_k127_4098151_3 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003007 342.0
TLS2_k127_4098151_4 thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 338.0
TLS2_k127_4098151_5 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 331.0
TLS2_k127_4098151_6 EVE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000008523 229.0
TLS2_k127_4098151_7 - - - - 0.0000000000000000000000000000000000000000000000000004923 186.0
TLS2_k127_4098151_8 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.00000000000000000000000000000000001657 134.0
TLS2_k127_4098151_9 - - - - 0.000000000000000000000007123 108.0
TLS2_k127_4117443_0 Cobalt chelatase (CbiK) K06042 - 5.4.99.60,5.4.99.61 1.885e-243 758.0
TLS2_k127_4117443_1 S-adenosylmethionine synthetase K00789 - 2.5.1.6 4.702e-231 717.0
TLS2_k127_4117443_10 RecA RadA K04482,K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004888 246.0
TLS2_k127_4117443_11 Glyoxalase-like domain K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000003703 227.0
TLS2_k127_4117443_12 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000008595 216.0
TLS2_k127_4117443_13 Tetrahydromethanopterin S-methyltransferase, subunit A K00577 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000000000000003598 216.0
TLS2_k127_4117443_14 ATP corrinoid adenosyltransferase K19221 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000003846 187.0
TLS2_k127_4117443_15 deoxyhypusine monooxygenase activity - - - 0.00000000000000000000000000000000000000000000000003036 188.0
TLS2_k127_4117443_16 snRNP Sm proteins K04796 - - 0.000000000000000000000000000000000000006688 145.0
TLS2_k127_4117443_17 Methyltransferase type 11 - - - 0.0000000000000000000000000000000001276 134.0
TLS2_k127_4117443_2 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 568.0
TLS2_k127_4117443_20 dUTPase - - - 0.0000000001089 66.0
TLS2_k127_4117443_21 PFAM SPFH domain Band 7 family - - - 0.000512 51.0
TLS2_k127_4117443_3 glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008593 556.0
TLS2_k127_4117443_4 Cobalamin synthesis G C-terminus K02189 - 3.7.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 542.0
TLS2_k127_4117443_6 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 392.0
TLS2_k127_4117443_7 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000462 347.0
TLS2_k127_4117443_8 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 336.0
TLS2_k127_4117443_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 284.0
TLS2_k127_4122249_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K15510,K21835 - 1.1.98.2,1.1.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004252 297.0
TLS2_k127_4122249_1 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000000000000000000000000001545 185.0
TLS2_k127_4122249_2 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000000003987 139.0
TLS2_k127_4122249_3 Protein of unknown function (DUF421) - - - 0.000000000000000000000002348 108.0
TLS2_k127_4122249_4 Spherulation-specific family 4 - - - 0.00000000000000005733 89.0
TLS2_k127_4122249_5 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K15510 - 1.1.98.2 0.0000000000001139 76.0
TLS2_k127_4122249_6 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000006149 61.0
TLS2_k127_4130139_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 5.073e-306 941.0
TLS2_k127_4130139_1 extracellular matrix structural constituent - - - 6.265e-229 722.0
TLS2_k127_4130139_10 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 GO:0003674,GO:0003824,GO:0004766,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0043919,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0050314,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.0000000000000000000000002116 107.0
TLS2_k127_4130139_11 YHS domain - - - 0.0000000000000000000000003756 104.0
TLS2_k127_4130139_12 PFAM Ammonia monooxygenase methane monooxygenase, subunit C K10946 - - 0.000000000000000002952 83.0
TLS2_k127_4130139_14 Zinc-finger associated domain (zf-AD) - GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043565,GO:0044212,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.000224 48.0
TLS2_k127_4130139_2 ABC-type transport system, involved in lipoprotein release, permease component K02004 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 1.697e-223 697.0
TLS2_k127_4130139_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 4.782e-194 612.0
TLS2_k127_4130139_4 LAO AO transport system ATPase K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005827 490.0
TLS2_k127_4130139_5 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 443.0
TLS2_k127_4130139_6 ABC-type antimicrobial peptide transport system, ATPase component K02003,K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 396.0
TLS2_k127_4130139_7 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000001536 263.0
TLS2_k127_4130139_8 Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001676 248.0
TLS2_k127_4130525_0 ribosomal protein L3 K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 586.0
TLS2_k127_4130525_1 Ribosomal protein L4 K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 443.0
TLS2_k127_4130525_2 Binds the lower part of the 30S subunit head K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003849 351.0
TLS2_k127_4130525_3 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004045 276.0
TLS2_k127_4130525_4 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003244 254.0
TLS2_k127_4130525_5 Putative RNA methyltransferase K09142 - - 0.00000000000000000000000000000000000000000000000002686 180.0
TLS2_k127_4130525_6 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.00000000000000000000000000000000000152 139.0
TLS2_k127_4130525_7 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000002287 63.0
TLS2_k127_4150562_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.115e-271 839.0
TLS2_k127_4150562_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 504.0
TLS2_k127_4150562_2 Prephenate dehydratase K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 402.0
TLS2_k127_4150562_3 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 310.0
TLS2_k127_4150562_4 Pterin binding enzyme K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000304 265.0
TLS2_k127_4150562_5 - - - - 0.00000000000000000000000000000000000000335 150.0
TLS2_k127_4166541_0 RNase L inhibitor, RLI K06174 - - 0.0 1082.0
TLS2_k127_4166541_1 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0 1010.0
TLS2_k127_4166541_11 - - - - 0.00000000000005421 77.0
TLS2_k127_4166541_2 von Willebrand factor (vWF) type A domain - - - 6.332e-294 908.0
TLS2_k127_4166541_3 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 3.879e-292 900.0
TLS2_k127_4166541_4 ATPase family associated with various cellular activities (AAA) K04748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 478.0
TLS2_k127_4166541_5 Met-10+ like-protein K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007416 417.0
TLS2_k127_4166541_6 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 386.0
TLS2_k127_4166541_7 Transketolase, pyridine binding domain protein K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 321.0
TLS2_k127_4166541_9 - - - - 0.0000000000000000000000000000000000000000003745 160.0
TLS2_k127_4168887_0 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.0 1095.0
TLS2_k127_4168887_1 Diphthamide biosynthesis K07561 - 2.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 599.0
TLS2_k127_4168887_2 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions - - - 0.000000000000000000000000000000000000000000002005 166.0
TLS2_k127_4168887_4 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K17686 - 3.6.3.4,3.6.3.54 0.00004721 48.0
TLS2_k127_4212744_0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 - 3.3.1.1 1.736e-236 735.0
TLS2_k127_4212744_1 3-hydroxyacyl-CoA dehydrogenase K15016 - 1.1.1.35,4.2.1.17 1.591e-207 649.0
TLS2_k127_4212744_2 phosphoribosyltransferases K04096,K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 293.0
TLS2_k127_4212744_3 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000009784 247.0
TLS2_k127_4237147_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 5.93e-321 986.0
TLS2_k127_4237147_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 6.949e-284 890.0
TLS2_k127_4237147_10 zinc finger - - - 0.000000000000000000000006605 102.0
TLS2_k127_4237147_13 Transposase - - - 0.00000000000003872 76.0
TLS2_k127_4237147_14 Cytochrome C oxidase, subunit II K00376,K02275 - 1.7.2.4,1.9.3.1 0.000000001473 67.0
TLS2_k127_4237147_15 Transposase - - - 0.000000004566 59.0
TLS2_k127_4237147_2 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 553.0
TLS2_k127_4237147_3 DEAD DEAH box helicase K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 550.0
TLS2_k127_4237147_4 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 335.0
TLS2_k127_4237147_5 thioesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000004326 237.0
TLS2_k127_4237147_6 PFAM transposase, IS4 family protein - - - 0.00000000000000000000000000000000000000000000003277 174.0
TLS2_k127_4237147_8 PFAM MazG nucleotide pyrophosphohydrolase - - - 0.000000000000000000000000000000001618 130.0
TLS2_k127_4237147_9 RNA-binding protein contains TRAM domain - - - 0.000000000000000000000000000000002825 129.0
TLS2_k127_4288163_0 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0 1292.0
TLS2_k127_4288163_1 Initiation factor K03242 - - 2.495e-248 769.0
TLS2_k127_4288163_10 - - - - 0.0000000000000000000000000000000000000000000000000008554 188.0
TLS2_k127_4288163_11 Ser thr protein kinase K07176 - - 0.000000000000000000000000000000000000000009528 160.0
TLS2_k127_4288163_12 transporter K03453 - - 0.00000000000002703 84.0
TLS2_k127_4288163_2 Deoxyhypusine synthase K00809 - 2.5.1.46 1.374e-211 661.0
TLS2_k127_4288163_3 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 3.049e-195 619.0
TLS2_k127_4288163_4 Deoxyhypusine synthase K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 545.0
TLS2_k127_4288163_5 Inositol monophosphatase K01082,K01092 - 3.1.3.25,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 437.0
TLS2_k127_4288163_6 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008651 332.0
TLS2_k127_4288163_7 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000000000000000000000000000001323 238.0
TLS2_k127_4288163_8 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000000000000000000000000000000103 224.0
TLS2_k127_4288163_9 Nucleotide binding protein, PINc K07158 - - 0.000000000000000000000000000000000000000000000000000000001299 202.0
TLS2_k127_4359765_1 PFAM Integral membrane protein TerC K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006531 381.0
TLS2_k127_4359765_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009235 281.0
TLS2_k127_4359765_5 MgtC family K07507 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004938 262.0
TLS2_k127_4359765_6 DsrE/DsrF-like family K06039 - - 0.0000000000000000000000000000000001294 134.0
TLS2_k127_4359765_7 domain protein K13735 - - 0.000007941 57.0
TLS2_k127_4367239_0 Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 411.0
TLS2_k127_4367239_1 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005236 264.0
TLS2_k127_4367239_2 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000003128 194.0
TLS2_k127_4367239_4 Universal stress protein - - - 0.000000000000000000000001234 109.0
TLS2_k127_4459814_0 Radical SAM K06937 - - 0.0 1145.0
TLS2_k127_4459814_1 oligoendopeptidase F - - - 5.687e-230 721.0
TLS2_k127_4459814_2 PFAM Rieske 2Fe-2S domain K00411 - 1.10.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000174 282.0
TLS2_k127_4459814_3 regulatory protein, arsR - - - 0.0000000000000000000000000000000000000000000000000000000479 201.0
TLS2_k127_4472420_0 NOSIC (NUC001) domain K14564 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 498.0
TLS2_k127_4472420_1 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005426 497.0
TLS2_k127_4472420_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 305.0
TLS2_k127_4472420_3 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259 - 0.0000000000000000000000000000000000000000000000000000000000000000004548 238.0
TLS2_k127_4472420_4 Transposase, is605 orfb family K07496 - - 0.00007774 45.0
TLS2_k127_4544607_0 UbiD family decarboxylase K03182 - 4.1.1.98 6.831e-286 881.0
TLS2_k127_4544607_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 2.205e-267 826.0
TLS2_k127_4544607_10 Creatininase K01470 - 3.5.2.10 0.00000000000000000000000000000000002062 138.0
TLS2_k127_4544607_11 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000000000000000000000005717 134.0
TLS2_k127_4544607_2 Nucleotidyltransferase domain K07076 - - 5.53e-216 682.0
TLS2_k127_4544607_3 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) - - - 2.526e-214 668.0
TLS2_k127_4544607_4 Radical SAM K18285 - 2.5.1.120 2.313e-212 665.0
TLS2_k127_4544607_5 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 477.0
TLS2_k127_4544607_6 Diphthamide synthase K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003704 316.0
TLS2_k127_4544607_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008565 250.0
TLS2_k127_4544607_8 - - - - 0.00000000000000000000000000000000000000000000000000000000001018 209.0
TLS2_k127_4544607_9 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000000000000000000000000008994 172.0
TLS2_k127_4576505_0 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 311.0
TLS2_k127_4576505_1 Domain of unknown function (DUF4443) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 299.0
TLS2_k127_4576505_11 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.000000003417 59.0
TLS2_k127_4576505_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 295.0
TLS2_k127_4576505_3 - - - - 0.00000000000000000000000000000000000000000000000000008295 190.0
TLS2_k127_4576505_5 CBS domain - - - 0.000000000000000000000000000000000000000000000002721 177.0
TLS2_k127_4576505_6 PAC2 family K06869 - - 0.0000000000000000000000000000000004604 141.0
TLS2_k127_4576505_7 COG3631 Ketosteroid isomerase-related protein - - - 0.000000000000000000000000002791 115.0
TLS2_k127_4576505_8 response regulator, receiver - - - 0.000000000000000000001319 98.0
TLS2_k127_4609391_0 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009096 608.0
TLS2_k127_4609391_1 PP-loop family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003078 540.0
TLS2_k127_4609391_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007391 361.0
TLS2_k127_4609391_3 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001886 238.0
TLS2_k127_4609391_4 Protein of unknown function DUF126 K09128 - - 0.0000000000000000000000000000000000000000000000000000001005 199.0
TLS2_k127_4609391_5 - - - - 0.000000000000000000000000000000000000000000000000000137 200.0
TLS2_k127_4609391_6 - - - - 0.00000000000000000000000000000009554 127.0
TLS2_k127_462103_0 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 482.0
TLS2_k127_462103_1 Formyl transferase K01433 - 3.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 462.0
TLS2_k127_462103_2 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001323 271.0
TLS2_k127_462103_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000003245 230.0
TLS2_k127_462103_4 snRNP Sm proteins K04796 - - 0.000000000000000000000000000000000000002176 148.0
TLS2_k127_462103_5 Binds to the 23S rRNA K02922 - - 0.000000000000000000000000008284 109.0
TLS2_k127_4624746_0 Predicted membrane protein (DUF2254) - - - 0.000000000000000000005865 108.0
TLS2_k127_4624746_1 ATPase domain predominantly from Archaea K06921 - - 0.0000000000000000009826 99.0
TLS2_k127_4624746_2 PFAM Glycosyl transferase, group 1 - - - 0.00002085 49.0
TLS2_k127_4626790_0 Heat shock 70 kDa protein K04043 - - 0.0 1040.0
TLS2_k127_4626790_1 DnaJ central domain K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 564.0
TLS2_k127_4626790_3 Translation initiation factor K03238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004719 259.0
TLS2_k127_4626790_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002211 239.0
TLS2_k127_4626790_5 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000000000000000000000004473 239.0
TLS2_k127_4626790_6 Thioredoxin K03671 - - 0.000000000000000000000000000000000000000000000000000000000000002552 220.0
TLS2_k127_4715649_0 TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 - 2.6.1.16 2.15e-303 938.0
TLS2_k127_4715649_1 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 527.0
TLS2_k127_4715649_10 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001469 271.0
TLS2_k127_4715649_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000005078 228.0
TLS2_k127_4715649_12 ATP binding protein K06883 - - 0.000000000000000000000000000000000000000000003787 173.0
TLS2_k127_4715649_14 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000008913 134.0
TLS2_k127_4715649_15 - - - - 0.0000000000000000000000000001425 117.0
TLS2_k127_4715649_2 Belongs to the enoyl-CoA hydratase isomerase family K01715,K15019 - 4.2.1.116,4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 514.0
TLS2_k127_4715649_3 PFAM S-layer - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 512.0
TLS2_k127_4715649_4 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 443.0
TLS2_k127_4715649_5 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 416.0
TLS2_k127_4715649_6 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 362.0
TLS2_k127_4715649_7 conserved protein implicated in secretion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000915 358.0
TLS2_k127_4715649_8 magnesium chelatase K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005631 328.0
TLS2_k127_4715649_9 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 311.0
TLS2_k127_4723262_0 Cation transporter/ATPase, N-terminus K01537 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.8 4.183e-194 637.0
TLS2_k127_4723262_1 PFAM Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 497.0
TLS2_k127_4723262_11 - - - - 0.000000000001169 78.0
TLS2_k127_4723262_12 - - - - 0.000000000003664 74.0
TLS2_k127_4723262_15 lysozyme activity - - - 0.00009404 53.0
TLS2_k127_4723262_2 divalent heavy-metal cations transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 461.0
TLS2_k127_4723262_3 Transposase, is605 orfb family K07496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 456.0
TLS2_k127_4723262_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000008171 234.0
TLS2_k127_4723262_6 COG0433 Predicted ATPase K06915 - - 0.0000000000000000000000000000000000000000000000000000000002292 206.0
TLS2_k127_4723262_7 iron dependent repressor - - - 0.0000000000000000000000000000000000000000000000000000007311 196.0
TLS2_k127_4763502_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665,K06883 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 468.0
TLS2_k127_4763502_1 PFAM 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009557 346.0
TLS2_k127_4763502_11 Transcriptional regulator - - - 0.0005692 43.0
TLS2_k127_4763502_5 COG1522 Transcriptional regulators - - - 0.000000000000000001629 91.0
TLS2_k127_4763502_8 COG1522 Transcriptional regulators - - - 0.0000000000001759 73.0
TLS2_k127_4763504_0 Domain of unknown function (DUF373) K08975 - - 1.568e-199 627.0
TLS2_k127_4763504_1 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 303.0
TLS2_k127_4763504_2 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000000000000000000000000000000000000000001574 231.0
TLS2_k127_4763504_4 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000004155 62.0
TLS2_k127_4763504_5 Acetyltransferase (GNAT) family - - - 0.0000005779 57.0
TLS2_k127_4785705_0 Archaeal ammonia monooxygenase subunit A (AmoA) K10944 - 1.14.18.3,1.14.99.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009126 434.0
TLS2_k127_4785705_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 346.0
TLS2_k127_4785705_2 - - - - 0.0000000000000000000000000000000000000000000000000009929 183.0
TLS2_k127_4785705_4 - - - - 0.000000000000000000000001489 102.0
TLS2_k127_4785705_5 - - - - 0.00000000000000000000002858 99.0
TLS2_k127_4793375_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.0 1273.0
TLS2_k127_4793375_1 HELICc2 - - - 1.902e-309 954.0
TLS2_k127_4793375_10 ribosomal protein K02866 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007253 315.0
TLS2_k127_4793375_11 metal-dependent protease of the PAD1 JAB1 superfamily K21140 - 3.13.1.6 0.00000000000000000000000000000000000002161 147.0
TLS2_k127_4793375_12 tRNA intron endonuclease, N-terminal domain K01170 - 4.6.1.16 0.0000000000000000000000000000000000001649 144.0
TLS2_k127_4793375_14 - - - - 0.000000000000000000000000002759 112.0
TLS2_k127_4793375_2 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) - - - 1.32e-234 731.0
TLS2_k127_4793375_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 523.0
TLS2_k127_4793375_4 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 500.0
TLS2_k127_4793375_5 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008912 495.0
TLS2_k127_4793375_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000786 489.0
TLS2_k127_4793375_7 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 484.0
TLS2_k127_4793375_8 Domain of unknown function (DUF929) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009616 368.0
TLS2_k127_4793375_9 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007692 363.0
TLS2_k127_4873345_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.725e-262 816.0
TLS2_k127_4873345_1 DNA primase K02316 - - 1.179e-241 752.0
TLS2_k127_4873345_2 Archaeal Nre, N-terminal - - - 1.682e-212 664.0
TLS2_k127_4873345_3 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 537.0
TLS2_k127_4873345_4 Domain of unknown function DUF120 K07732 - 2.7.1.161 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 383.0
TLS2_k127_4873345_5 Cytidylyltransferase-like K00980,K14656 - 2.7.7.2,2.7.7.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 335.0
TLS2_k127_4873345_6 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 316.0
TLS2_k127_4873345_7 Toprim domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001885 235.0
TLS2_k127_4873345_8 - - - - 0.000000000000000000000000000000000000000000468 158.0
TLS2_k127_4873345_9 - - - - 0.0000000000000000000000000000000000000005759 150.0
TLS2_k127_4916163_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 320.0
TLS2_k127_4916163_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005187 238.0
TLS2_k127_4916163_10 Transcriptional regulator - - - 0.0000000000000313 77.0
TLS2_k127_4916163_11 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.0000000000106 68.0
TLS2_k127_4916163_12 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000002005 63.0
TLS2_k127_4916163_13 - - - - 0.000000002064 63.0
TLS2_k127_4916163_14 PFAM YcfA family protein - - - 0.000000007211 60.0
TLS2_k127_4916163_15 PIN domain K07064 - - 0.00000003619 60.0
TLS2_k127_4916163_16 toxin-antitoxin pair type II binding - - - 0.000005543 51.0
TLS2_k127_4916163_17 PFAM Uncharacterised protein family UPF0150 - - - 0.000009181 51.0
TLS2_k127_4916163_18 Psort location Cytoplasmic, score - - - 0.00002795 50.0
TLS2_k127_4916163_2 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000000000000000000000000000000000000000000000000000000000000000003531 227.0
TLS2_k127_4916163_20 - - - - 0.0004482 48.0
TLS2_k127_4916163_3 membrane protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001651 228.0
TLS2_k127_4916163_4 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000003246 207.0
TLS2_k127_4916163_6 zinc ion binding - - - 0.00000000000000000000000000000000000000000009471 168.0
TLS2_k127_4916163_7 Putative antitoxin - - - 0.0000000000000000000000000000000003873 134.0
TLS2_k127_4916163_8 Putative antitoxin - - - 0.000000000000000000000000000000001391 131.0
TLS2_k127_4916163_9 Tissue inhibitor of metalloproteinase - - - 0.00000000000000007266 89.0
TLS2_k127_5026635_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex - - - 1.397e-282 874.0
TLS2_k127_5026635_1 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 4.875e-240 746.0
TLS2_k127_5026635_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 2.035e-196 615.0
TLS2_k127_5026635_3 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 3.214e-194 610.0
TLS2_k127_5026635_4 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004757 516.0
TLS2_k127_5026635_5 Glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 361.0
TLS2_k127_5026635_6 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 309.0
TLS2_k127_5062163_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 1.362e-220 692.0
TLS2_k127_5062163_1 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 455.0
TLS2_k127_5062163_2 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000609 336.0
TLS2_k127_5062163_3 GTPase or GTP-binding protein K06947 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005044 337.0
TLS2_k127_5062163_4 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000001425 232.0
TLS2_k127_5062163_5 biosynthesis protein QueC K06920 - 6.3.4.20 0.00000000000000000000000000000000000000001527 160.0
TLS2_k127_5062163_7 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K02548,K17105,K20616 - 2.5.1.42,2.5.1.74 0.000000001071 61.0
TLS2_k127_5096919_0 Pyruvate phosphate dikinase K01006 - 2.7.9.1 0.0 1402.0
TLS2_k127_5096919_1 phosphohydrolase (DHH superfamily) K07097 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004492 495.0
TLS2_k127_5096919_10 Zinc finger, C2H2 type - - - 0.000000000000000000000003741 105.0
TLS2_k127_5096919_12 - - - - 0.00007344 45.0
TLS2_k127_5096919_2 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 402.0
TLS2_k127_5096919_3 UPF0126 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 319.0
TLS2_k127_5096919_4 HAD-superfamily hydrolase, subfamily IA, variant 3 K01091,K01838,K07025 - 3.1.3.18,5.4.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 287.0
TLS2_k127_5096919_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001646 227.0
TLS2_k127_5096919_6 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000000006477 205.0
TLS2_k127_5096919_7 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000001393 199.0
TLS2_k127_5096919_8 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000009399 175.0
TLS2_k127_5096919_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000000000001448 103.0
TLS2_k127_5122851_0 Circadian clock protein KaiC K06945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 413.0
TLS2_k127_5122851_1 COG0455 ATPases involved in chromosome partitioning K03496,K03609 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 358.0
TLS2_k127_5122851_2 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000000001042 153.0
TLS2_k127_5122851_3 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000002991 109.0
TLS2_k127_5122851_4 transcriptional - - - 0.00000000000000005256 84.0
TLS2_k127_5145304_0 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006338 304.0
TLS2_k127_5145304_3 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000193 96.0
TLS2_k127_5171918_0 hydroxymethylglutaryl-CoA reductase (NADPH) activity K00021 - 1.1.1.34 0.0 1233.0
TLS2_k127_5171918_1 Mannosyl-3-phosphoglycerate synthase K05947 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.217 1.152e-210 659.0
TLS2_k127_5171918_10 Aldo/keto reductase family - - - 0.0000001749 55.0
TLS2_k127_5171918_2 Sodium hydrogen exchanger - - - 1.966e-200 631.0
TLS2_k127_5171918_3 CBS domain K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009956 572.0
TLS2_k127_5171918_4 UbiA prenyltransferase K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 456.0
TLS2_k127_5171918_5 Uncharacterized conserved protein (DUF2203) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000784 252.0
TLS2_k127_5171918_6 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000000009238 135.0
TLS2_k127_5171918_7 MOFRL family K11529 - 2.7.1.165 0.000000000000000002593 88.0
TLS2_k127_5171918_9 - - - - 0.000000000478 66.0
TLS2_k127_5180380_0 restriction endonuclease K03546,K06915,K07448 - - 0.0 1199.0
TLS2_k127_5180380_1 Aldehyde dehydrogenase family K00294 - 1.2.1.88 2.544e-284 878.0
TLS2_k127_5180380_10 Ferritin-like domain K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 404.0
TLS2_k127_5180380_11 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 355.0
TLS2_k127_5180380_12 riboflavin synthase, alpha K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 329.0
TLS2_k127_5180380_13 NADPH-dependent F420 reductase K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 308.0
TLS2_k127_5180380_14 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003678 292.0
TLS2_k127_5180380_15 RibD C-terminal domain K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 291.0
TLS2_k127_5180380_17 Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity K08096 - 3.5.4.29 0.000000000000000000000000000000000000000000000000000000000000000007647 234.0
TLS2_k127_5180380_19 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000000521 213.0
TLS2_k127_5180380_2 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 2.603e-255 791.0
TLS2_k127_5180380_20 PilT protein domain protein - - - 0.000000000000000000000000000000000000000000000000000000000005447 211.0
TLS2_k127_5180380_21 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K05710 - - 0.00000000000000000000000000000000000000000000000000005535 190.0
TLS2_k127_5180380_22 Transposase, is605 orfb family K07496 - - 0.0000000000000000000000000000000000000136 146.0
TLS2_k127_5180380_23 - - - - 0.00000000000000000000000001513 111.0
TLS2_k127_5180380_24 flavodoxin nitric oxide synthase - - - 0.00000000000000000000000007261 108.0
TLS2_k127_5180380_26 Mechanosensitive ion channel - - - 0.00000000000000000001342 93.0
TLS2_k127_5180380_28 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000000001051 87.0
TLS2_k127_5180380_3 Membrane-bound serine protease (ClpP class) K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 612.0
TLS2_k127_5180380_4 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006516 579.0
TLS2_k127_5180380_5 aspartate carbamoyltransferase K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003678 552.0
TLS2_k127_5180380_6 including yeast histone deacetylase and acetoin utilization protein K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005811 522.0
TLS2_k127_5180380_7 COG0330 Membrane protease subunits stomatin prohibitin homologs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 460.0
TLS2_k127_5180380_8 PHP-associated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003529 442.0
TLS2_k127_5180380_9 Transposase, is605 orfb family K07496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 410.0
TLS2_k127_5197163_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 2.035e-223 697.0
TLS2_k127_5197163_1 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 384.0
TLS2_k127_5197163_2 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 345.0
TLS2_k127_5197163_3 archaeal coiled-coil protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 328.0
TLS2_k127_5284122_0 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 514.0
TLS2_k127_5284122_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001164 276.0
TLS2_k127_5284122_2 Copper resistance protein D - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000194 247.0
TLS2_k127_5284122_3 Archaeal TRASH domain - - - 0.000000000000000000000000000000000000000000000000000000001592 204.0
TLS2_k127_5284122_4 - - - - 0.000000000000000000000000000000000000000000000000002106 188.0
TLS2_k127_5284122_5 Psort location Periplasmic, score K09807 - - 0.00000000000000000004591 102.0
TLS2_k127_5319379_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 403.0
TLS2_k127_5319379_3 response regulator, receiver - - - 0.000000000000000003311 91.0
TLS2_k127_5320174_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 586.0
TLS2_k127_5320174_1 Predicted membrane protein (DUF2070) K08979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 378.0
TLS2_k127_5320174_2 Ribose 5-phosphate isomerase K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005382 321.0
TLS2_k127_5320174_3 Belongs to the SUI1 family K03113 - - 0.00000000000000000000000000000000000000000000000000000003914 196.0
TLS2_k127_5320174_5 Large-conductance mechanosensitive channel, MscL K03282 - - 0.0000000000000000000000000000000001035 135.0
TLS2_k127_5320174_6 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) K07143 - - 0.00000000000000000000000000216 117.0
TLS2_k127_5320174_7 Sec61beta family - - - 0.0000000000000000000006833 95.0
TLS2_k127_5410946_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007217 291.0
TLS2_k127_5410946_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.00000000000000000000000000000000000000000000000000005062 190.0
TLS2_k127_5410946_2 PFAM Phosphoribosyltransferase - - - 0.000000000000000000000000000000000000000000000001298 182.0
TLS2_k127_5410946_3 COG3631 Ketosteroid isomerase-related protein - - - 0.000000000000000000000005684 105.0
TLS2_k127_5410946_4 PFAM UspA domain protein - - - 0.00000000000001784 79.0
TLS2_k127_5410946_5 PFAM CBS domain - - - 0.0000000003911 67.0
TLS2_k127_5434083_0 Radical SAM K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 539.0
TLS2_k127_5434083_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000041 289.0
TLS2_k127_5434083_2 RNA polymerase Rpb3/Rpb11 dimerisation domain K03056 - 2.7.7.6 0.00000000000000000000000000000000000000002705 154.0
TLS2_k127_5434083_3 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.0000000000000000000000000000000000000001497 152.0
TLS2_k127_5434083_4 SNARE associated Golgi protein - - - 0.0000000000004931 75.0
TLS2_k127_5438251_0 Pirin C-terminal cupin domain K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 394.0
TLS2_k127_5438251_1 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000593 237.0
TLS2_k127_5438251_10 histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000006878 70.0
TLS2_k127_5438251_11 - - - - 0.0000008561 63.0
TLS2_k127_5438251_12 - - - - 0.0001017 52.0
TLS2_k127_5438251_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001397 233.0
TLS2_k127_5438251_4 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000006856 196.0
TLS2_k127_5438251_5 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.000000000000000000000000000000000000000003005 163.0
TLS2_k127_5438251_6 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000000000000008383 154.0
TLS2_k127_5438251_7 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases K03641 - - 0.000000000000000000131 105.0
TLS2_k127_5438251_8 PFAM Ammonia monooxygenase methane monooxygenase, subunit C K10946 - - 0.000000000000000002952 83.0
TLS2_k127_5457174_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 2418.0
TLS2_k127_5457174_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K13798 - 2.7.7.6 0.0 2055.0
TLS2_k127_5457174_10 GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 338.0
TLS2_k127_5457174_11 protein secretion by the type IV secretion system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 309.0
TLS2_k127_5457174_12 Mn2 -dependent serine threonine protein kinase K08851 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 301.0
TLS2_k127_5457174_13 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003655 285.0
TLS2_k127_5457174_14 Belongs to the HAM1 NTPase family K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000001344 253.0
TLS2_k127_5457174_15 Queuosine biosynthesis protein QueC K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000009939 226.0
TLS2_k127_5457174_16 Participates in transcription termination K02600 - - 0.0000000000000000000000000000000000000000000000000000000001521 207.0
TLS2_k127_5457174_17 Cupin superfamily (DUF985) K09705 - - 0.0000000000000000000000000000000000000000000000000000000004431 208.0
TLS2_k127_5457174_18 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000000000000000000000000001089 160.0
TLS2_k127_5457174_19 - - - - 0.00000000000000000000000000000000000000006297 153.0
TLS2_k127_5457174_2 GTPase of unknown function C-terminal K06942 - - 2.377e-227 707.0
TLS2_k127_5457174_20 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.000000000000000000000000000000000000006486 147.0
TLS2_k127_5457174_21 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K13798 - 2.7.7.6 0.00000000000000000000000000000000002932 134.0
TLS2_k127_5457174_22 Belongs to the class-I aminoacyl-tRNA synthetase family - - - 0.0000000000001013 71.0
TLS2_k127_5457174_3 - - - - 1.352e-198 623.0
TLS2_k127_5457174_4 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 578.0
TLS2_k127_5457174_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 533.0
TLS2_k127_5457174_6 NGG1p interacting factor 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 426.0
TLS2_k127_5457174_7 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 373.0
TLS2_k127_5457174_8 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 370.0
TLS2_k127_5457174_9 ATPase family associated with various cellular activities (AAA) K04800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 354.0
TLS2_k127_552753_0 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005746 497.0
TLS2_k127_552753_1 Tetrapyrrole (Corrin/Porphyrin) Methylases K05936 - 2.1.1.133,2.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 474.0
TLS2_k127_552753_10 Sodium/calcium exchanger protein K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004604 270.0
TLS2_k127_552753_11 Tetrapyrrole (Corrin/Porphyrin) Methylases K03394 - 2.1.1.130,2.1.1.151 0.00000000000000000000000000000000000000000000000000000000000000000000004214 247.0
TLS2_k127_552753_12 COG2303 Choline dehydrogenase and related flavoproteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000009526 257.0
TLS2_k127_552753_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000002021 214.0
TLS2_k127_552753_14 sister chromatid segregation - - - 0.0000000000000000000000000000000000000000000001067 177.0
TLS2_k127_552753_15 WD40-like Beta Propeller Repeat K03641 - - 0.0000000000000000000000000000000000000000000004595 185.0
TLS2_k127_552753_17 - - - - 0.00000000000000000000000000000000000001993 145.0
TLS2_k127_552753_18 - - - - 0.00000000000000000000000000000000000716 138.0
TLS2_k127_552753_19 - - - - 0.000000000000000000000000007014 115.0
TLS2_k127_552753_2 Asp/Glu/Hydantoin racemase K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 457.0
TLS2_k127_552753_20 - - - - 0.00000000000000000000000001345 110.0
TLS2_k127_552753_21 PFAM UspA domain protein - - - 0.0000000000000002557 84.0
TLS2_k127_552753_24 zinc finger - - - 0.0000000000002491 70.0
TLS2_k127_552753_25 Transcriptional regulator - - - 0.00000000001305 69.0
TLS2_k127_552753_26 Transposase, is605 orfb family K07496 - - 0.000001445 51.0
TLS2_k127_552753_29 oxidoreductase activity - - - 0.0005638 48.0
TLS2_k127_552753_3 NOSIC (NUC001) domain K14564 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007326 445.0
TLS2_k127_552753_4 COG0668 Small-conductance mechanosensitive channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 397.0
TLS2_k127_552753_5 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 371.0
TLS2_k127_552753_6 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009246 346.0
TLS2_k127_552753_7 conserved protein implicated in secretion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 324.0
TLS2_k127_552753_8 metal-binding integral membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001679 283.0
TLS2_k127_5552155_0 DEAD/H associated K03724 - - 0.0 1573.0
TLS2_k127_5552155_1 Succinyl-CoA ligase like flavodoxin domain K18593 - - 0.0 1258.0
TLS2_k127_5552155_10 PFAM GCN5-related N-acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000000000000000000000001782 256.0
TLS2_k127_5552155_12 transcriptional regulators - - - 0.000000000000000000000000000000000000000000009127 164.0
TLS2_k127_5552155_14 Domain of unknown function (DUF202) K00389 - - 0.000000000000000000000000000000000000000004906 158.0
TLS2_k127_5552155_15 Sodium:sulfate symporter transmembrane region - - - 0.0000000000000000000000000002291 121.0
TLS2_k127_5552155_16 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0000000000002497 70.0
TLS2_k127_5552155_2 Peptidase dimerisation domain - - - 2.013e-241 751.0
TLS2_k127_5552155_3 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 2.205e-236 738.0
TLS2_k127_5552155_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006805 594.0
TLS2_k127_5552155_5 ABC-type multidrug transport system, ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 496.0
TLS2_k127_5552155_6 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 416.0
TLS2_k127_5552155_7 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009607 392.0
TLS2_k127_5552155_9 Zinc finger domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 337.0
TLS2_k127_5576517_0 Anticodon-binding domain of tRNA K01873 - 6.1.1.9 0.0 1042.0
TLS2_k127_5576517_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 3.761e-305 942.0
TLS2_k127_5576517_2 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 378.0
TLS2_k127_5576517_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009824 244.0
TLS2_k127_5576517_5 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms K07027 - - 0.000000000000007738 85.0
TLS2_k127_5576517_7 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.0000568 48.0
TLS2_k127_5632514_0 Heme copper-type cytochrome quinol K02274 - 1.9.3.1 1.626e-280 867.0
TLS2_k127_5632514_1 PFAM Iron-containing alcohol dehydrogenase K18602 - - 2.586e-202 631.0
TLS2_k127_5632514_2 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 385.0
TLS2_k127_5632514_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006733 383.0
TLS2_k127_5632514_4 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000053 369.0
TLS2_k127_5632514_5 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006697 340.0
TLS2_k127_5632514_6 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001367 285.0
TLS2_k127_5632514_7 Heme copper-type cytochrome quinol oxidases, subunit 2 K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000005886 234.0
TLS2_k127_5632514_8 Cytochrome oxidase assembly protein K02259 - - 0.00000000000000000000000000000000000000000000000000000000016 207.0
TLS2_k127_5632514_9 - - - - 0.000000000000001822 79.0
TLS2_k127_567676_0 ABC1 family - - - 9.881e-263 818.0
TLS2_k127_567676_1 PFAM (2R)-phospho-3-sulfolactate synthase ComA K08097 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 4.4.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 564.0
TLS2_k127_567676_2 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000004004 244.0
TLS2_k127_567676_3 - - - - 0.00000000000000000000000000000000000000000000000000000003554 200.0
TLS2_k127_567676_4 Belongs to the small heat shock protein (HSP20) family - - - 0.000000000000000000000000000000000000000000000000003203 185.0
TLS2_k127_567676_5 TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family K02051 - - 0.000000000000000000000000000000000000000000000001001 176.0
TLS2_k127_567676_6 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.00000000000002036 72.0
TLS2_k127_5757099_0 PFAM type II secretion system protein E K07332 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 489.0
TLS2_k127_5757099_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 381.0
TLS2_k127_5757099_2 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002215 241.0
TLS2_k127_5757099_3 PFAM type II secretion system K07333 - - 0.00000000000000000000000000000000000000000000000000000000000000000009544 254.0
TLS2_k127_5757099_4 Phospholipase D. Active site motifs. K01115 - 3.1.4.4 0.00000000000000000000000000000000000000000000000000000000000004388 235.0
TLS2_k127_5757099_5 membrane protein domain - - - 0.000000000000000000000000000000000000000000000005267 177.0
TLS2_k127_5757099_6 Calcineurin-like phosphoesterase - - - 0.000000002018 70.0
TLS2_k127_5757099_8 TIGRFAM archaeal flagellin N-terminal-like domain - - - 0.0008902 49.0
TLS2_k127_5785559_0 Peptidase family M1 domain K01256,K13722 - 3.4.11.2 0.0 1238.0
TLS2_k127_5785559_1 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 1.385e-318 984.0
TLS2_k127_5785559_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000085 284.0
TLS2_k127_5785559_12 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004897 279.0
TLS2_k127_5785559_13 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002306 245.0
TLS2_k127_5785559_14 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000004698 202.0
TLS2_k127_5785559_15 - - - - 0.000000000000000000000000000000000000000000000000007493 183.0
TLS2_k127_5785559_16 - - - - 0.00000000000000000000000000000001069 134.0
TLS2_k127_5785559_17 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.00000000000000000000000000001033 123.0
TLS2_k127_5785559_18 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000005168 125.0
TLS2_k127_5785559_2 Vinylacetyl-CoA Delta-isomerase K14534 - 4.2.1.120,5.3.3.3 4.198e-301 926.0
TLS2_k127_5785559_20 - - - - 0.000000000000000007688 88.0
TLS2_k127_5785559_21 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000448 84.0
TLS2_k127_5785559_23 Transposase, is605 orfb family K07496 - - 0.0001341 45.0
TLS2_k127_5785559_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 1.344e-196 615.0
TLS2_k127_5785559_4 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007188 485.0
TLS2_k127_5785559_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 348.0
TLS2_k127_5785559_6 MafB19-like deaminase K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 346.0
TLS2_k127_5785559_7 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006915 339.0
TLS2_k127_5785559_8 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 325.0
TLS2_k127_5785559_9 COG2406 Protein distantly related to bacterial ferritins K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 305.0
TLS2_k127_5822218_0 COG0733 Na -dependent transporters of the SNF family K03308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 355.0
TLS2_k127_5822218_1 CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000002063 228.0
TLS2_k127_5822218_2 CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000001373 216.0
TLS2_k127_5822218_6 Universal stress protein - - - 0.00000000000000004855 86.0
TLS2_k127_5822218_7 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.0000000000000000557 89.0
TLS2_k127_5920034_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1407.0
TLS2_k127_5920034_1 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 441.0
TLS2_k127_5920034_3 Belongs to the P(II) protein family K04751 - - 0.000000000000000002762 89.0
TLS2_k127_5920034_4 - - - - 0.00001094 48.0
TLS2_k127_5948105_0 Protein of unknown function, DUF255 K06888 - - 0.0 1157.0
TLS2_k127_5948105_1 - - - - 0.000000000000000000000000000000000000000000001307 167.0
TLS2_k127_5948105_5 Pyridoxamine 5'-phosphate K07005 - - 0.00004754 45.0
TLS2_k127_5997273_0 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 404.0
TLS2_k127_5997273_1 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008191 356.0
TLS2_k127_5997273_10 - - - - 0.0000000000000000007585 98.0
TLS2_k127_5997273_11 membrane protein domain - - - 0.00000000003266 66.0
TLS2_k127_5997273_12 - - - - 0.0000001309 60.0
TLS2_k127_5997273_2 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000003457 239.0
TLS2_k127_5997273_3 membrane protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001476 231.0
TLS2_k127_5997273_4 Protein of unknown function (DUF998) - - - 0.00000000000000000000000000000000000001588 153.0
TLS2_k127_5997273_6 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000002223 141.0
TLS2_k127_5997273_7 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000002806 121.0
TLS2_k127_5997273_8 - - - - 0.00000000000000000000000001006 115.0
TLS2_k127_6007932_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 1.153e-258 802.0
TLS2_k127_6007932_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 1.282e-255 793.0
TLS2_k127_6007932_10 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 388.0
TLS2_k127_6007932_11 Belongs to the universal ribosomal protein uS5 family K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 377.0
TLS2_k127_6007932_12 PFAM TfuA domain protein, core - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 338.0
TLS2_k127_6007932_13 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 325.0
TLS2_k127_6007932_15 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 307.0
TLS2_k127_6007932_16 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 307.0
TLS2_k127_6007932_17 ribosomal protein K02907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002683 279.0
TLS2_k127_6007932_18 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000003475 265.0
TLS2_k127_6007932_19 Winged helix-turn-helix DNA-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004804 246.0
TLS2_k127_6007932_2 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.61e-250 779.0
TLS2_k127_6007932_20 HD domain K07023 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005495 244.0
TLS2_k127_6007932_21 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000002317 221.0
TLS2_k127_6007932_22 Probable cobalt transporter subunit (CbtA) - - - 0.0000000000000000000000000000000000000000000000000000000000005868 219.0
TLS2_k127_6007932_23 - - - - 0.0000000000000000000000000000000000000000000000000000002629 195.0
TLS2_k127_6007932_24 - - - - 0.000000000000000000000000000000000000000000000000000008623 194.0
TLS2_k127_6007932_25 - - - - 0.00000000000000000000000000000000000000000000000004791 181.0
TLS2_k127_6007932_28 - - - - 0.000000000000000000000000000000000000000000009127 164.0
TLS2_k127_6007932_29 - - - - 0.000000000000000000000000000000000000000001058 159.0
TLS2_k127_6007932_3 methanogenesis marker protein 1 K09136 - - 4.348e-247 767.0
TLS2_k127_6007932_30 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000002665 151.0
TLS2_k127_6007932_32 AAA domain K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.0000000000000000000000000000000000001952 148.0
TLS2_k127_6007932_33 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000002335 136.0
TLS2_k127_6007932_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 8.633e-247 767.0
TLS2_k127_6007932_5 LOR SDH bifunctional - - - 1.804e-234 730.0
TLS2_k127_6007932_6 - - - - 2.513e-214 681.0
TLS2_k127_6007932_7 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K11131 - - 9.569e-197 616.0
TLS2_k127_6007932_8 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 609.0
TLS2_k127_6007932_9 resistance protein K14166 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 612.0
TLS2_k127_6035199_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 385.0
TLS2_k127_6035199_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 370.0
TLS2_k127_6035199_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 298.0
TLS2_k127_6035199_3 - - - - 0.00000000000000000000000000000000000000000001743 164.0
TLS2_k127_6035199_4 response regulator, receiver - - - 0.000000000000000000000000000000000000000003183 165.0
TLS2_k127_6035199_5 PFAM UvrD REP helicase K03657,K03658 - 3.6.4.12 0.00000000000000000000000000000000000000003077 158.0
TLS2_k127_6035199_6 Transposase, IS605 OrfB family K07496 - - 0.000000000000000000000000000000000002749 143.0
TLS2_k127_6035199_8 Probable transposase K07496 - - 0.0005446 45.0
TLS2_k127_609900_0 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 606.0
TLS2_k127_609900_1 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 481.0
TLS2_k127_609900_2 Proteasome endopeptidase complex K03432 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 441.0
TLS2_k127_609900_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009232 384.0
TLS2_k127_609900_4 Putative RNA methyltransferase K09142 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 296.0
TLS2_k127_609900_5 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001027 240.0
TLS2_k127_609900_6 Domain of unknown function (DUF371) K09738 - - 0.00000000000000000000000000000000000000000000000000000000000000002417 225.0
TLS2_k127_6125952_0 Radical SAM - - - 0.0 1186.0
TLS2_k127_6125952_1 Isocitrate isopropylmalate dehydrogenase K00031 - 1.1.1.42 2.274e-206 643.0
TLS2_k127_6125952_10 RNA polymerase Rpb4 K03051 - 2.7.7.6 0.000000000000000000000000000000000000000000000006423 176.0
TLS2_k127_6125952_11 - - - - 0.000000000000000000000000000000000000000004357 156.0
TLS2_k127_6125952_12 Methyltransferase small domain K02493 - 2.1.1.297 0.00000000000000001378 89.0
TLS2_k127_6125952_13 PFAM Ammonia monooxygenase methane monooxygenase, subunit C K10946 - - 0.00000000000000138 76.0
TLS2_k127_6125952_2 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 469.0
TLS2_k127_6125952_3 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 398.0
TLS2_k127_6125952_4 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 348.0
TLS2_k127_6125952_5 Monooxygenase subunit B protein K10945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 337.0
TLS2_k127_6125952_6 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 295.0
TLS2_k127_6125952_7 Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007532 278.0
TLS2_k127_6125952_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005883 263.0
TLS2_k127_6125952_9 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.00000000000000000000000000000000000000000000000001214 181.0
TLS2_k127_6143351_0 Uncharacterised protein family (UPF0182) K09118 - - 0.0 1372.0
TLS2_k127_6143351_1 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 592.0
TLS2_k127_6143351_10 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000001381 170.0
TLS2_k127_6143351_11 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000000000000001295 145.0
TLS2_k127_6143351_12 - - - - 0.00000000000000000000000000000000007266 136.0
TLS2_k127_6143351_13 Antibiotic biosynthesis monooxygenase - - - 0.00000000005294 68.0
TLS2_k127_6143351_2 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 584.0
TLS2_k127_6143351_3 DNA methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 551.0
TLS2_k127_6143351_4 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000347 557.0
TLS2_k127_6143351_5 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 451.0
TLS2_k127_6143351_6 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 435.0
TLS2_k127_6143351_7 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 376.0
TLS2_k127_6143351_8 glutamine amidotransferase K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000005351 233.0
TLS2_k127_6206413_0 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 527.0
TLS2_k127_6206413_1 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 319.0
TLS2_k127_6206413_2 PFAM Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007809 312.0
TLS2_k127_6206413_3 Pyridine nucleotide-disulfide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000001999 161.0
TLS2_k127_6206413_4 Zinc-binding dehydrogenase K13953 - 1.1.1.1 0.00000000000003687 78.0
TLS2_k127_6235664_0 Subtilase family - - - 0.0 1865.0
TLS2_k127_6235664_1 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.0 1011.0
TLS2_k127_6235664_10 Binds to the 23S rRNA K02896 - - 0.000000000000000000000000000000000000995 138.0
TLS2_k127_6235664_11 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.00000000000000000000000000000001129 127.0
TLS2_k127_6235664_12 PFAM TCP-1 cpn60 chaperonin family K22447 - - 0.000000000000000000000000000005492 119.0
TLS2_k127_6235664_13 zinc finger - - - 0.0000000000000002222 79.0
TLS2_k127_6235664_2 Belongs to the phosphohexose mutase family K15778 - 5.4.2.2,5.4.2.8 1.612e-236 738.0
TLS2_k127_6235664_3 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 474.0
TLS2_k127_6235664_4 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007595 477.0
TLS2_k127_6235664_5 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 287.0
TLS2_k127_6235664_6 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000000000002377 246.0
TLS2_k127_6235664_7 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000000000000000000000005757 226.0
TLS2_k127_6235664_8 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000000000000000000000000000001045 222.0
TLS2_k127_6235664_9 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000000000008279 139.0
TLS2_k127_6284763_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 5.207e-260 803.0
TLS2_k127_6284763_1 COG1522 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 574.0
TLS2_k127_6284763_10 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001771 266.0
TLS2_k127_6284763_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002269 264.0
TLS2_k127_6284763_12 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000754 175.0
TLS2_k127_6284763_13 endonuclease K00986 - 2.7.7.49 0.0000000000000000000000000000000000000000067 156.0
TLS2_k127_6284763_14 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000000000000000007326 155.0
TLS2_k127_6284763_15 Winged helix-turn-helix - - - 0.00000000000000000000000000000000000007519 144.0
TLS2_k127_6284763_18 - - - - 0.000000000000000000001443 96.0
TLS2_k127_6284763_2 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006377 570.0
TLS2_k127_6284763_3 FeS assembly ATPase SufC K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006831 488.0
TLS2_k127_6284763_4 Chlorite dismutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005188 385.0
TLS2_k127_6284763_5 F420-0:Gamma-glutamyl ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 324.0
TLS2_k127_6284763_6 3-isopropylmalate dehydratase, small subunit K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005285 314.0
TLS2_k127_6284763_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 297.0
TLS2_k127_6284763_8 Domain of unknown function (DUF1802) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 290.0
TLS2_k127_6284763_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003322 265.0
TLS2_k127_6291260_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009772 591.0
TLS2_k127_6291260_1 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008006 417.0
TLS2_k127_6291260_2 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065,K13252 - 2.1.3.3,2.1.3.6,2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 368.0
TLS2_k127_6291260_3 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 291.0
TLS2_k127_6291260_4 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.000000000000000000000000000000000000000000000000000000000000001365 222.0
TLS2_k127_6291260_5 Transposase, is605 orfb family K07496 - - 0.000000000000000000000000000000000000000000000000000000002469 202.0
TLS2_k127_6291260_6 - - - - 0.000000000000000000000000000000000000000000000000000009131 192.0
TLS2_k127_6291260_7 Transposase, is605 orfb family K07496 - - 0.000000000000000000000000000000000000000000002283 167.0
TLS2_k127_6341762_0 Transcriptional regulator - - - 0.0000000000000000000000000003484 117.0
TLS2_k127_6341762_1 Transcriptional regulator - - - 0.000000000000000001529 89.0
TLS2_k127_6341762_2 xyloglucan:xyloglucosyl transferase activity K07004 - - 0.000000000000002291 87.0
TLS2_k127_6341762_3 - - - - 0.000000000000008337 84.0
TLS2_k127_6431794_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 1.357e-261 817.0
TLS2_k127_6431794_1 Transposase, is605 orfb family K07496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 486.0
TLS2_k127_6431794_2 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 316.0
TLS2_k127_6431794_4 - - - - 0.0000000000000000000000000000000000005553 142.0
TLS2_k127_6431794_5 PFAM NHL repeat containing protein - - - 0.000000000000000000000001727 111.0
TLS2_k127_6431794_6 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.0000000000003273 74.0
TLS2_k127_6431794_7 Sulfotransferase domain - - - 0.0000000000005683 80.0
TLS2_k127_6431794_8 - - - - 0.00001623 58.0
TLS2_k127_6449162_0 resistance protein K14166 - - 0.0 1174.0
TLS2_k127_6449162_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 - - 2.773e-268 828.0
TLS2_k127_6449162_2 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005219 484.0
TLS2_k127_6449162_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001293 237.0
TLS2_k127_6449162_4 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000000000001191 206.0
TLS2_k127_6449162_5 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.0000000000000000000000000000000000000000000000000000000004583 211.0
TLS2_k127_6449162_6 - - - - 0.00000000000000000000000000000000000000000000005073 175.0
TLS2_k127_6449162_7 serine-type endopeptidase activity - - - 0.00000000000000000000000000000576 125.0
TLS2_k127_6449162_8 copper ion binding - - - 0.0000000000000000000000009624 109.0
TLS2_k127_6449162_9 Transposase, is605 orfb family K07496 - - 0.00000000000000000001764 94.0
TLS2_k127_6705515_0 RNA-metabolising metallo-beta-lactamase K07041 - - 0.0 1004.0
TLS2_k127_6705515_1 Phenylalanyl-tRNA synthetase alpha subunit K01889 - 6.1.1.20 5.89e-254 789.0
TLS2_k127_6705515_11 Cytidylyltransferase-like K02201 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000008624 220.0
TLS2_k127_6705515_12 - - - - 0.0000000000000000000000000000000000000000000000000000002922 196.0
TLS2_k127_6705515_13 Peptidase M10A and M12B matrixin and adamalysin - - - 0.000000000000000000000000000000000000000000001181 173.0
TLS2_k127_6705515_14 RNA-binding protein contains TRAM domain - - - 0.00000000000000000000000000000002929 129.0
TLS2_k127_6705515_15 - - - - 0.000000000000000000000000000001097 124.0
TLS2_k127_6705515_16 elongation factor Tu - - - 0.0000000002601 61.0
TLS2_k127_6705515_17 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000002054 65.0
TLS2_k127_6705515_18 PKD domain containing protein - - - 0.000002332 52.0
TLS2_k127_6705515_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01867 - 6.1.1.2 3.432e-235 729.0
TLS2_k127_6705515_3 Transcriptional regulator, TrmB - - - 1.004e-223 706.0
TLS2_k127_6705515_4 Thiamine biosynthesis protein (ThiI) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 567.0
TLS2_k127_6705515_5 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000446 554.0
TLS2_k127_6705515_6 ferredoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004551 352.0
TLS2_k127_6705515_7 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004864 332.0
TLS2_k127_6705515_8 V4R K07013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003239 274.0
TLS2_k127_6705515_9 Protein of unknown function DUF99 K09120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007181 268.0
TLS2_k127_6792559_0 Domain of unknown function (DUF1297) K06863 - 6.3.4.23 6.779e-216 672.0
TLS2_k127_6792559_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 406.0
TLS2_k127_6792559_10 PBS lyase HEAT-like repeat K06072 - 1.14.99.29 0.000000000000000000000000000001926 122.0
TLS2_k127_6792559_11 Putative Phosphatase K01079 - 3.1.3.3 0.0000000000000000000009323 103.0
TLS2_k127_6792559_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007116 381.0
TLS2_k127_6792559_3 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 379.0
TLS2_k127_6792559_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 309.0
TLS2_k127_6792559_5 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006324 247.0
TLS2_k127_6792559_6 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000001243 246.0
TLS2_k127_6792559_7 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000000000000000000000000000000002328 225.0
TLS2_k127_6792559_8 mttA/Hcf106 family K03116 - - 0.000000000000000000000000000000000000002212 148.0
TLS2_k127_6792559_9 - - - - 0.00000000000000000000000000000000000001947 144.0
TLS2_k127_6825527_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 9.926e-299 921.0
TLS2_k127_6825527_1 DNA polymerase IV (family X) K02347 - - 4.361e-280 870.0
TLS2_k127_6825527_10 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.000000000000000000000000000000000000000000000000000000000000004513 240.0
TLS2_k127_6825527_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000009427 222.0
TLS2_k127_6825527_12 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000002278 216.0
TLS2_k127_6825527_13 PPIC-type PPIASE domain K07533 - 5.2.1.8 0.00000000000000000000000000000000000000000000006809 170.0
TLS2_k127_6825527_15 - - - - 0.000000000000000000000000000000000000001001 148.0
TLS2_k127_6825527_16 - - - - 0.000000000000000000000000000000000004748 138.0
TLS2_k127_6825527_17 cheY-homologous receiver domain K03413 - - 0.000000000000000000000324 108.0
TLS2_k127_6825527_18 Peptidase M10A and M12B matrixin and adamalysin - - - 0.00000000000000000168 95.0
TLS2_k127_6825527_19 Transcriptional regulatory protein, C terminal - - - 0.000000000000000004335 89.0
TLS2_k127_6825527_2 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 542.0
TLS2_k127_6825527_20 cheY-homologous receiver domain - - - 0.00000000000000009813 85.0
TLS2_k127_6825527_3 Transposase, is605 orfb family K07496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 477.0
TLS2_k127_6825527_5 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008193 400.0
TLS2_k127_6825527_6 DnaJ-class molecular chaperone with C-terminal Zn finger domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005238 289.0
TLS2_k127_6825527_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003344 270.0
TLS2_k127_6825527_8 protein conserved in archaea K09723 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002086 261.0
TLS2_k127_6825527_9 HD domain K00951,K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000368 243.0
TLS2_k127_6846775_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.997e-316 972.0
TLS2_k127_6846775_1 Chorismate mutase type II K00812 - 2.6.1.1 1.378e-202 639.0
TLS2_k127_6846775_10 carbon-nitrogen ligase activity, with glutamine as amido-N-donor - - - 0.000000000000000000000000000000000000000000000000003569 187.0
TLS2_k127_6846775_11 ATP synthase (F/14-kDa) subunit K02122 - - 0.0000000000000000000000000000000000000000000000001466 179.0
TLS2_k127_6846775_12 DnaJ molecular chaperone homology domain K03686 - - 0.0000000000000000000000000000000000000000000000007842 178.0
TLS2_k127_6846775_13 Polyketide cyclase dehydrase - - - 0.00000000000000000000000000000000000000000000003619 173.0
TLS2_k127_6846775_2 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 541.0
TLS2_k127_6846775_3 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 513.0
TLS2_k127_6846775_4 pfkB family carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 414.0
TLS2_k127_6846775_5 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 367.0
TLS2_k127_6846775_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000134 284.0
TLS2_k127_6846775_7 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003228 282.0
TLS2_k127_6846775_8 ribosomal protein K02976 - - 0.0000000000000000000000000000000000000000000000000000001602 195.0
TLS2_k127_6846775_9 - - - - 0.000000000000000000000000000000000000000000000000000013 193.0
TLS2_k127_6854993_0 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009969 524.0
TLS2_k127_6854993_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 447.0
TLS2_k127_6854993_3 Spherulation-specific family 4 - - - 0.00000000000002277 80.0
TLS2_k127_6854993_5 Belongs to the P(II) protein family K04751,K04752 - - 0.0004809 47.0
TLS2_k127_6855442_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 5e-227 713.0
TLS2_k127_6855442_1 Sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 549.0
TLS2_k127_6855442_2 RNA methylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000665 391.0
TLS2_k127_6855442_3 Rieske 2Fe-2S K05710 - - 0.00000000000000000000000000000000000000000000000000007508 187.0
TLS2_k127_6855442_4 Protein of unknown function (DUF763) K09003 - - 0.00000000000000000000000000000000000001385 145.0
TLS2_k127_6855442_5 - - - - 0.00000000000000000000000000000000836 130.0
TLS2_k127_6855442_6 - - - - 0.000000000000000000000003579 104.0
TLS2_k127_6855442_7 Thiamine-binding protein - - - 0.0000000000000003663 81.0
TLS2_k127_6855442_8 Transposase, is605 orfb family K07496 - - 0.0000000557 56.0
TLS2_k127_6869757_0 Belongs to the PdaD family K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 323.0
TLS2_k127_6869757_1 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001767 265.0
TLS2_k127_6869757_2 - - - - 0.0000000000000000000000000000000000000000000000000000000004495 205.0
TLS2_k127_6869757_4 Antibiotic biosynthesis monooxygenase K21481 - 1.14.99.57 0.000000000000000000000008842 104.0
TLS2_k127_6869757_5 Pyruvyl transferase - - - 0.00000000000000009559 92.0
TLS2_k127_6869757_6 Permeases of the major facilitator superfamily - - - 0.00000000000004689 84.0
TLS2_k127_6869757_7 response regulator, receiver - - - 0.0000000000007358 74.0
TLS2_k127_6869757_8 phosphorelay signal transduction system - - - 0.00000000677 62.0
TLS2_k127_696123_0 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 2.665e-209 654.0
TLS2_k127_696123_1 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 552.0
TLS2_k127_6966619_0 AhpC/TSA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003961 520.0
TLS2_k127_6966619_1 cytochrome c biogenesis protein K06196 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 413.0
TLS2_k127_6966619_2 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009007 280.0
TLS2_k127_6966619_3 Bacterial regulatory protein, arsR family - - - 0.0000000000000000000000000000000000000000000000002291 178.0
TLS2_k127_6966619_5 - - - - 0.000000000000000000000000000000000000000001209 157.0
TLS2_k127_6971204_0 Radical SAM - - - 0.0 1046.0
TLS2_k127_6971204_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 5.179e-292 904.0
TLS2_k127_6971204_10 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006533 514.0
TLS2_k127_6971204_11 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 511.0
TLS2_k127_6971204_12 phosphoserine phosphatase K01079 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 396.0
TLS2_k127_6971204_13 Amino acid kinase family K06981 - 2.7.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 338.0
TLS2_k127_6971204_14 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 301.0
TLS2_k127_6971204_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000551 271.0
TLS2_k127_6971204_17 - - - - 0.0000000000000000000000000000000000000000000000000000003384 194.0
TLS2_k127_6971204_18 Transposase, is605 orfb family K07496 - - 0.00000000000000000000000000000000000000000005041 162.0
TLS2_k127_6971204_2 von Willebrand factor, type A K07114 - - 7.692e-249 774.0
TLS2_k127_6971204_20 redox protein, regulator of disulfide bond formation - - - 0.000000000000000000000000000000000000003148 147.0
TLS2_k127_6971204_21 COG1239 Mg-chelatase subunit ChlI K03405 - 6.6.1.1 0.00000000000000000000000000000000000007217 155.0
TLS2_k127_6971204_23 Peptidase M10A and M12B matrixin and adamalysin - - - 0.00000001108 62.0
TLS2_k127_6971204_3 TPR repeat - - - 2.971e-200 629.0
TLS2_k127_6971204_4 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 604.0
TLS2_k127_6971204_5 Cysteine synthase K12339 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 600.0
TLS2_k127_6971204_6 oxidoreductase FAD NAD(P)-binding K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 562.0
TLS2_k127_6971204_7 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 556.0
TLS2_k127_6971204_8 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 550.0
TLS2_k127_6971204_9 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 516.0
TLS2_k127_7045217_0 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 2.826e-205 643.0
TLS2_k127_7045217_1 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 556.0
TLS2_k127_7045217_2 Archaeal transcriptional regulator TrmB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 416.0
TLS2_k127_7045217_3 PFAM Iron dependent repressor, metal binding and dimerisation domain K03709 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000369 274.0
TLS2_k127_7045217_4 - - - - 0.00000000000000000000000000000000000000000000000002766 183.0
TLS2_k127_7045217_5 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000001307 90.0
TLS2_k127_7045217_6 Transcriptional regulator - - - 0.00000000000000003157 85.0
TLS2_k127_7045217_7 Radical SAM K06937 - - 0.0007936 44.0
TLS2_k127_7114436_0 nitrite reductase [NAD(P)H] activity K00158,K00363,K03809,K05710 - 1.2.3.3,1.6.5.2,1.7.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007271 476.0
TLS2_k127_7114436_2 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000002719 170.0
TLS2_k127_7114436_3 membrane protein domain - - - 0.00000000000000000000000001047 115.0
TLS2_k127_7114436_4 response regulator, receiver K07668,K07669 - - 0.0000000000000000000009234 99.0
TLS2_k127_7114436_5 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000004139 81.0
TLS2_k127_7114436_6 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000003162 82.0
TLS2_k127_7168247_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 3.782e-207 651.0
TLS2_k127_7168247_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 439.0
TLS2_k127_7168247_2 GHMP kinases N terminal domain K00891 - 2.7.1.71 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 436.0
TLS2_k127_7168247_3 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 303.0
TLS2_k127_7168247_4 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000127 136.0
TLS2_k127_7168247_5 histone deacetylase K11276 - - 0.0003881 44.0
TLS2_k127_7186749_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 3.542e-297 924.0
TLS2_k127_7186749_1 Phosphoglycolate phosphatase K22223 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 392.0
TLS2_k127_7186749_2 tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000512 390.0
TLS2_k127_7186749_3 PFAM TCP-1 cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.0000000000000000000000000003997 113.0
TLS2_k127_7186749_4 - - - - 0.0002281 47.0
TLS2_k127_723659_0 Beta propeller domain - - - 2.335e-284 891.0
TLS2_k127_723659_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 8.659e-233 734.0
TLS2_k127_723659_10 Ferritin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000064 372.0
TLS2_k127_723659_11 PFAM TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006638 382.0
TLS2_k127_723659_12 uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005038 340.0
TLS2_k127_723659_13 Protein of unknown function (DUF541) K09807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 333.0
TLS2_k127_723659_14 peptidyl-prolyl cis-trans isomerase K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007374 311.0
TLS2_k127_723659_15 PFAM regulatory protein TetR K03577,K18939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 296.0
TLS2_k127_723659_16 Hemerythrin HHE cation binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000809 286.0
TLS2_k127_723659_17 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000002288 253.0
TLS2_k127_723659_18 Archease protein family (MTH1598/TM1083) - - - 0.00000000000000000000000000000000000000000000000000000000000005425 216.0
TLS2_k127_723659_19 - - - - 0.000000000000000000000000000000000000000000000000000000000001848 216.0
TLS2_k127_723659_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K00836 - 2.6.1.19,2.6.1.76 1.174e-197 622.0
TLS2_k127_723659_21 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000843 201.0
TLS2_k127_723659_22 RNase H K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000027 194.0
TLS2_k127_723659_23 - - - - 0.0000000000000000000000000000000000000000000000000000399 188.0
TLS2_k127_723659_24 - - - - 0.00000000000000000000000000000000000000000000000000006674 187.0
TLS2_k127_723659_26 - - - - 0.000000000000000000000000000000000000000001921 161.0
TLS2_k127_723659_27 - - - - 0.000000000000000000000000000000000000000004874 162.0
TLS2_k127_723659_29 - - - - 0.00000000000000000000000000000000001079 138.0
TLS2_k127_723659_3 histidyl-tRNA synthetase K01892 - 6.1.1.21 9.486e-195 614.0
TLS2_k127_723659_30 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.00000000000000000000000000000000002749 141.0
TLS2_k127_723659_31 Associated with various cellular activities K03551 - 3.6.4.12 0.000000000000000000000000000001558 130.0
TLS2_k127_723659_32 - - - - 0.000000000000000000000000000007618 122.0
TLS2_k127_723659_4 COG1960 Acyl-CoA dehydrogenases K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005937 601.0
TLS2_k127_723659_5 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 563.0
TLS2_k127_723659_6 Belongs to the UPF0284 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008824 475.0
TLS2_k127_723659_7 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006339 477.0
TLS2_k127_723659_8 deoxyhypusine monooxygenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006917 423.0
TLS2_k127_723659_9 Major Intrinsic Protein K06188,K09866 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 404.0
TLS2_k127_7328112_0 UbiD family decarboxylase - - - 3.936e-226 707.0
TLS2_k127_7328112_3 - - - - 0.000000000000000000000000000000000000005588 148.0
TLS2_k127_7328112_4 - - - - 0.000000000000000000000000000004828 118.0
TLS2_k127_7328112_5 Sodium:sulfate symporter transmembrane region K14445 - - 0.000000000000000000000000005414 117.0
TLS2_k127_7328112_6 Sodium:sulfate symporter transmembrane region K14445 - - 0.000000000003088 69.0
TLS2_k127_7328112_7 PFAM Sodium sulfate symporter transmembrane region K14445 - - 0.00000000000332 70.0
TLS2_k127_7332445_0 Large family of predicted nucleotide-binding domains K06865 - - 0.0 1035.0
TLS2_k127_7332445_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 584.0
TLS2_k127_7332445_10 iron dependent repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001427 252.0
TLS2_k127_7332445_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000002033 224.0
TLS2_k127_7332445_12 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000000000000000002427 203.0
TLS2_k127_7332445_13 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000000000000000000000000000000000000000000007384 177.0
TLS2_k127_7332445_14 Trm112p-like protein - - - 0.00000000000000000000000000000000000005833 145.0
TLS2_k127_7332445_15 Lrp/AsnC ligand binding domain - - - 0.00000000000000001303 82.0
TLS2_k127_7332445_16 Lrp/AsnC ligand binding domain - - - 0.00000000000005627 72.0
TLS2_k127_7332445_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 533.0
TLS2_k127_7332445_3 Oxidoreductase family, NAD-binding Rossmann fold K18855 - 1.1.1.374 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 485.0
TLS2_k127_7332445_4 D-isomer specific 2-hydroxyacid dehydrogenase K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005149 466.0
TLS2_k127_7332445_5 Protein of unknown function (DUF354) K09726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 435.0
TLS2_k127_7332445_6 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005195 398.0
TLS2_k127_7332445_7 Nicotinamide-nucleotide adenylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 298.0
TLS2_k127_7332445_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006165 297.0
TLS2_k127_7332445_9 Hexapeptide repeat of succinyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000429 261.0
TLS2_k127_7361557_0 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L K00341 - 1.6.5.3 3.757e-306 943.0
TLS2_k127_7361557_1 Proton-conducting membrane transporter K00342 - 1.6.5.3 3.135e-291 901.0
TLS2_k127_7361557_10 nonribosomal peptide K00666,K01897,K18660,K18661 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008456 554.0
TLS2_k127_7361557_11 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 548.0
TLS2_k127_7361557_12 Phosphate uptake regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 523.0
TLS2_k127_7361557_13 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 511.0
TLS2_k127_7361557_14 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 444.0
TLS2_k127_7361557_15 kinase, sugar kinase superfamily K06982 - 2.7.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 420.0
TLS2_k127_7361557_16 Peptidyl-prolyl cis-trans K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 413.0
TLS2_k127_7361557_17 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 395.0
TLS2_k127_7361557_18 Belongs to the complex I 20 kDa subunit family K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009557 346.0
TLS2_k127_7361557_19 4Fe-4S binding domain K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007638 340.0
TLS2_k127_7361557_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 7.509e-250 773.0
TLS2_k127_7361557_20 Pfam:DUF137 K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 341.0
TLS2_k127_7361557_21 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 331.0
TLS2_k127_7361557_22 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 307.0
TLS2_k127_7361557_23 Translin family K07477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008217 292.0
TLS2_k127_7361557_24 NADH ubiquinone oxidoreductase 27 kD subunit K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 290.0
TLS2_k127_7361557_25 A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003451 272.0
TLS2_k127_7361557_26 AhpC/TSA antioxidant enzyme K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000008784 254.0
TLS2_k127_7361557_27 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 3 K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000006369 249.0
TLS2_k127_7361557_28 Iron-sulfur cluster assembly accessory protein K13628 - - 0.0000000000000000000000000000000000000000000000000000000000000001717 225.0
TLS2_k127_7361557_29 Cupin - - - 0.000000000000000000000000000000000000000000000000000000000000002223 220.0
TLS2_k127_7361557_3 Belongs to the complex I 49 kDa subunit family K00333 - 1.6.5.3 1.996e-248 767.0
TLS2_k127_7361557_30 Cyclophilin-like K09143 - - 0.00000000000000000000000000000000000000000000000001932 182.0
TLS2_k127_7361557_31 NADH ubiquinone oxidoreductase subunit 11 or 4L (chain K) K00340 - 1.6.5.3 0.0000000000000000000000000000000000000000000007358 168.0
TLS2_k127_7361557_32 mttA/Hcf106 family K03116 - - 0.000000000000000000000000000000000000000000006058 165.0
TLS2_k127_7361557_33 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000006454 164.0
TLS2_k127_7361557_34 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.00000000000000000000000000000000000000001106 154.0
TLS2_k127_7361557_37 COG4618 ABC-type protease lipase transport system, ATPase and permease components - - - 0.000000000002097 72.0
TLS2_k127_7361557_4 NADH dehydrogenase K00337 - 1.6.5.3 3.619e-238 739.0
TLS2_k127_7361557_5 Aminotransferase class-V - - - 6.783e-236 731.0
TLS2_k127_7361557_6 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 2.144e-228 713.0
TLS2_k127_7361557_7 geranylgeranyl reductase K17830 - 1.3.1.101,1.3.7.11 9.887e-214 668.0
TLS2_k127_7361557_8 AhpC/TSA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 569.0
TLS2_k127_7361557_9 Belongs to the peptidase M24B family K01262,K01271 - 3.4.11.9,3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 558.0
TLS2_k127_995036_0 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 1.999e-254 790.0
TLS2_k127_995036_1 phosphoglycerate mutase K15635 - 5.4.2.12 1.142e-228 714.0
TLS2_k127_995036_10 Heme copper-type cytochrome quinol K02274 - 1.9.3.1 0.000000000000000000000000000000000000000000001526 171.0
TLS2_k127_995036_11 - - - - 0.000000000000000000000000000000000000000002786 160.0
TLS2_k127_995036_12 - - - - 0.000000000000000000000000000000000000000008531 159.0
TLS2_k127_995036_13 RNA-binding protein involved in rRNA processing K07569 - - 0.000000000000000000000000000002245 121.0
TLS2_k127_995036_14 - - - - 0.00000000000000000000000000003506 120.0
TLS2_k127_995036_16 Heme copper-type cytochrome quinol K02274 - 1.9.3.1 0.0000000000000002944 79.0
TLS2_k127_995036_2 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 6.479e-200 625.0
TLS2_k127_995036_20 Major facilitator superfamily - - - 0.000004376 52.0
TLS2_k127_995036_3 factor TFIIB K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008692 535.0
TLS2_k127_995036_4 Trypsin-like serine protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008232 404.0
TLS2_k127_995036_5 nucleotidyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 383.0
TLS2_k127_995036_6 chromosome segregation and condensation protein ScpA K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 376.0
TLS2_k127_995036_7 segregation and condensation protein K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 297.0
TLS2_k127_995036_8 Ribosomal protein S8e K02995 - - 0.0000000000000000000000000000000000000000000000000000000003044 204.0
TLS2_k127_995036_9 SRP19 protein K03105 - - 0.00000000000000000000000000000000000000000000005639 173.0