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Overview

ID MAG04004
Name TLS2_bin.40
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family Rhodocyclaceae
Genus Fen-999
Species
Assembly information
Completeness (%) 78.67
Contamination (%) 4.19
GC content (%) 64.0
N50 (bp) 6,518
Genome size (bp) 2,296,713

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2550

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1016841_0 Citrate transporter - - - 2.038e-270 850.0
TLS2_k127_1016841_1 Sulfate transporter antisigma-factor antagonist STAS - - - 4.061e-249 787.0
TLS2_k127_1016841_2 Proton-conducting membrane transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 389.0
TLS2_k127_1017505_0 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 515.0
TLS2_k127_1017505_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000004672 216.0
TLS2_k127_1017505_2 LytTr DNA-binding domain K02477,K07705 - - 0.00000000000000000000000000000000000434 147.0
TLS2_k127_1017505_3 - - - - 0.00000000000000000000000000000005811 136.0
TLS2_k127_1021378_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 8.614e-236 732.0
TLS2_k127_1021378_1 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 516.0
TLS2_k127_1021378_2 COG3170 Tfp pilus assembly protein FimV K08086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004052 527.0
TLS2_k127_1021378_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 481.0
TLS2_k127_1021378_4 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007301 381.0
TLS2_k127_1021378_5 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006271 387.0
TLS2_k127_1021378_6 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001658 347.0
TLS2_k127_1021378_7 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000001006 255.0
TLS2_k127_1021378_8 Sporulation related domain K03749 - - 0.000000000000000000004961 98.0
TLS2_k127_1021378_9 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates - - - 0.00000000000000005354 89.0
TLS2_k127_102697_0 Soluble lytic murein transglycosylase L domain K08309 - - 9.356e-200 641.0
TLS2_k127_102697_1 epimerase dehydratase K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004249 313.0
TLS2_k127_102697_2 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - 0.0000000000000000000000000000000000000000000000000000007587 198.0
TLS2_k127_102697_3 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000001887 121.0
TLS2_k127_1031649_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 577.0
TLS2_k127_1031649_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000001412 207.0
TLS2_k127_1031649_2 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000000000000003117 203.0
TLS2_k127_1031649_3 PIN domain - - - 0.0000000000000000000000000003564 119.0
TLS2_k127_1031649_4 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000001209 74.0
TLS2_k127_1036725_0 N-6 DNA methylase K03427 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 481.0
TLS2_k127_1036725_1 COG2202 FOG PAS PAC domain K03776 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 426.0
TLS2_k127_1036725_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 397.0
TLS2_k127_1036725_3 His Kinase A (phosphoacceptor) domain K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 359.0
TLS2_k127_1036725_4 Pfam Dinitrogenase iron-molybdenum cofactor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 301.0
TLS2_k127_1036725_5 diguanylate cyclase - - - 0.00000000000000000000000000000000001447 151.0
TLS2_k127_1036725_6 nitrogen fixation K02593 - - 0.000000000000000000000000000000002434 129.0
TLS2_k127_1036725_7 4Fe-4S binding domain - - - 0.00000000000000000000000000004849 121.0
TLS2_k127_1036725_8 - - - - 0.00000001819 63.0
TLS2_k127_10403_0 Putative diguanylate phosphodiesterase K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006845 555.0
TLS2_k127_10403_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 413.0
TLS2_k127_10403_2 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000003453 210.0
TLS2_k127_10403_3 - - - - 0.0000000000000000000000000000000000000000000006337 177.0
TLS2_k127_1041938_0 PFAM DMSO reductase anchor subunit (DmsC) K21309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 472.0
TLS2_k127_1041938_1 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 441.0
TLS2_k127_1041938_2 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001305 273.0
TLS2_k127_1041938_3 Sulfurtransferase TusA K04085 - - 0.000000000000000000000000000000007905 129.0
TLS2_k127_1041938_4 PFAM 4Fe-4S K00184,K21308 - - 0.0000000000000000000000000007638 112.0
TLS2_k127_1041938_5 Domain of unknown function DUF302 - - - 0.000000000001633 72.0
TLS2_k127_1046057_0 ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 297.0
TLS2_k127_1046057_1 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002554 284.0
TLS2_k127_1046057_2 protein involved in tolerance to divalent cations K03926 - - 0.000000000000000000000000000000000000000000004565 165.0
TLS2_k127_1046288_0 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 578.0
TLS2_k127_1046288_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004439 379.0
TLS2_k127_1046288_2 Membrane transport protein K07088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 334.0
TLS2_k127_1046288_3 ATPases involved in chromosome partitioning - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006488 324.0
TLS2_k127_1046288_4 Type 12 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003306 249.0
TLS2_k127_1046288_5 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000004436 204.0
TLS2_k127_1046288_6 - - - - 0.000000000000000000000000000000000002121 142.0
TLS2_k127_1046288_7 branched-chain amino acid K01996 - - 0.000000000000006082 74.0
TLS2_k127_1046288_8 - - - - 0.00000000001268 65.0
TLS2_k127_1049079_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 9.761e-241 751.0
TLS2_k127_1049079_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000002095 138.0
TLS2_k127_1049079_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000003829 144.0
TLS2_k127_1049079_3 - - - - 0.000000000000000000000000003644 117.0
TLS2_k127_1058271_0 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 504.0
TLS2_k127_1058271_1 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 348.0
TLS2_k127_106145_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 4.39e-264 827.0
TLS2_k127_106145_1 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 3.436e-239 751.0
TLS2_k127_106145_2 poly(R)-hydroxyalkanoic acid synthase K03821 - - 1.918e-207 649.0
TLS2_k127_106145_3 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 302.0
TLS2_k127_106145_4 Thiol disulfide interchange protein K03673 - - 0.0000000000000000000000000000000000000000000006077 174.0
TLS2_k127_106145_5 Sodium:solute symporter family - - - 0.000000000000000000000000000000000001855 139.0
TLS2_k127_106145_6 cell division protein - - - 0.000000000000000000000000000000002396 137.0
TLS2_k127_106145_7 nucleic acid-binding protein, contains PIN domain - - - 0.0000000000000000000000003855 121.0
TLS2_k127_1067574_0 Protein of unknown function - - - 4.303e-249 802.0
TLS2_k127_1067574_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 3.443e-237 752.0
TLS2_k127_1071766_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 3.894e-201 630.0
TLS2_k127_1071766_1 Alpha-amylase domain K01187 - 3.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005038 354.0
TLS2_k127_1071766_2 PFAM Conserved TM helix repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004877 256.0
TLS2_k127_1084172_0 twitching motility protein K02670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004672 573.0
TLS2_k127_1084172_1 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 548.0
TLS2_k127_1084172_2 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 424.0
TLS2_k127_1084172_3 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 - 2.1.1.298 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003594 396.0
TLS2_k127_1084172_4 DsrE/DsrF-like family - - - 0.00000000000000000000000000003093 122.0
TLS2_k127_1084172_5 - - - - 0.000000001191 58.0
TLS2_k127_1084172_6 - - - - 0.000009263 48.0
TLS2_k127_1086090_0 RND efflux system, outer membrane lipoprotein K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 518.0
TLS2_k127_1086090_1 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006669 461.0
TLS2_k127_1086090_10 protein conserved in bacteria K03690 - - 0.000000000000000000000000000000000000003711 153.0
TLS2_k127_1086090_11 acetyltransferase - - - 0.0000002306 63.0
TLS2_k127_1086090_2 FAD linked oxidase, C-terminal domain-containing protein 6 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 439.0
TLS2_k127_1086090_3 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 400.0
TLS2_k127_1086090_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 379.0
TLS2_k127_1086090_5 import inner membrane translocase subunit Tim44 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008676 286.0
TLS2_k127_1086090_6 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001894 274.0
TLS2_k127_1086090_7 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000000000000000000008755 199.0
TLS2_k127_1086090_8 - - - - 0.00000000000000000000000000000000000000000000000000001635 210.0
TLS2_k127_1086090_9 Histidine triad (HIT) - - - 0.00000000000000000000000000000000000000000000786 168.0
TLS2_k127_1086732_0 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004872 488.0
TLS2_k127_1086732_1 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 372.0
TLS2_k127_1086732_2 HAD-hyrolase-like K22292 - 3.1.3.105 0.00000000000000000000000000000000000000000000000000000000000000000001679 239.0
TLS2_k127_1086732_3 Belongs to the ompA family K03286 - - 0.000000000000000000000000000000000000000000000000000000000000003949 224.0
TLS2_k127_1096993_0 Transposase - - - 1.762e-222 694.0
TLS2_k127_1096993_1 Transposase, Mutator family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007179 562.0
TLS2_k127_1096993_2 Transposase, Mutator family K07493 - - 0.00000000134 60.0
TLS2_k127_1096993_3 PFAM transposase mutator type K07493 - - 0.0003405 46.0
TLS2_k127_1119615_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 7.939e-262 814.0
TLS2_k127_1119615_1 Part of a membrane complex involved in electron transport K03615 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 507.0
TLS2_k127_1147036_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.361e-316 977.0
TLS2_k127_1147036_1 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 7.714e-220 684.0
TLS2_k127_1147036_2 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 9.061e-204 639.0
TLS2_k127_1147036_3 Parallel beta-helix repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 566.0
TLS2_k127_1147036_4 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007698 428.0
TLS2_k127_1147036_5 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008317 379.0
TLS2_k127_1147036_6 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008646 377.0
TLS2_k127_1147036_7 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 338.0
TLS2_k127_1147036_8 SpoIIAA-like - - - 0.0000000000000000000000000000000000000004107 157.0
TLS2_k127_1147036_9 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000005639 81.0
TLS2_k127_1184093_0 Fic/DOC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004409 358.0
TLS2_k127_1184093_1 helix_turn_helix ASNC type - - - 0.000000000000000000000000000000000000000000000005921 179.0
TLS2_k127_1184093_2 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) K04762 - - 0.0000000000000000000000000000000000000001812 153.0
TLS2_k127_1184093_3 amino acid K01999 - - 0.00000000000000000000000000000000001996 141.0
TLS2_k127_1184093_4 Protein conserved in bacteria K09954 - - 0.000000000000000000000000000000001763 131.0
TLS2_k127_1184093_5 Outer membrane protein V K07274 - - 0.000000000000000000000000000000003712 139.0
TLS2_k127_1193583_0 Transposase IS116/IS110/IS902 family K07486 - - 0.00000000000000000000000000000000000000001848 166.0
TLS2_k127_1193583_1 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia K01426 - 3.5.1.4 0.00000000000001502 73.0
TLS2_k127_1199174_0 Extracellular solute-binding protein K17321 - - 0.0 1067.0
TLS2_k127_1199174_1 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 3.863e-282 885.0
TLS2_k127_1199174_10 binding-protein-dependent transport systems inner membrane component K17323 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 488.0
TLS2_k127_1199174_11 PFAM regulatory protein DeoR K02444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 399.0
TLS2_k127_1199174_12 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 315.0
TLS2_k127_1199174_13 G T U mismatch-specific DNA glycosylase K03649 - 3.2.2.28 0.00000000000000000000000000000000000000000000000000000000000004579 218.0
TLS2_k127_1199174_14 Protein of unknown function (DUF3014) - - - 0.000000000000000000000000000000000000000000000000000000001135 212.0
TLS2_k127_1199174_15 Domain of unknown function (DUF1841) - - - 0.0000000000000000000000000000000000000000000000000001868 188.0
TLS2_k127_1199174_16 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000001533 194.0
TLS2_k127_1199174_17 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000001745 175.0
TLS2_k127_1199174_18 Predicted small integral membrane protein (DUF2160) - - - 0.000000000000000000000000000000000000000000002601 175.0
TLS2_k127_1199174_19 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000124 136.0
TLS2_k127_1199174_2 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 2.834e-240 755.0
TLS2_k127_1199174_20 Methyltransferase domain - - - 0.00000000000000000000000008059 115.0
TLS2_k127_1199174_3 FAD dependent oxidoreductase K00111 - 1.1.5.3 1.537e-227 715.0
TLS2_k127_1199174_4 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 6.769e-218 684.0
TLS2_k127_1199174_5 Hsp90 protein K04079 - - 3.589e-197 618.0
TLS2_k127_1199174_6 PLD-like domain K06132 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006087 627.0
TLS2_k127_1199174_7 Belongs to the ABC transporter superfamily K17325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005889 561.0
TLS2_k127_1199174_8 PFAM binding-protein-dependent transport systems inner membrane component K17322 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009354 533.0
TLS2_k127_1199174_9 Belongs to the ABC transporter superfamily K17324 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 531.0
TLS2_k127_1206399_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 3.808e-230 726.0
TLS2_k127_1206399_1 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 485.0
TLS2_k127_1206399_2 glutamine synthetase K01915,K20712 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 432.0
TLS2_k127_1206399_3 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000002964 231.0
TLS2_k127_1206399_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K01947,K03525 - 2.7.1.33,6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000008044 229.0
TLS2_k127_1206399_5 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000001731 178.0
TLS2_k127_1206399_6 Domain of unknown function (DUF4124) - - - 0.000000000000000000000000000000002144 135.0
TLS2_k127_1208883_0 3-hydroxyacyl-CoA dehydrogenase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 4.326e-284 897.0
TLS2_k127_1208883_1 AcyL-CoA dehydrogenase K06445 - - 1.471e-278 862.0
TLS2_k127_1208883_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 1.683e-265 826.0
TLS2_k127_1208883_3 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 6.502e-213 673.0
TLS2_k127_1208883_4 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 325.0
TLS2_k127_1208883_5 Chalcone isomerase-like - - - 0.00000000000000000000000000000000000000000000000000001091 197.0
TLS2_k127_1208883_6 transcriptional - - - 0.00000000000000000000000000000000000000000000000007719 179.0
TLS2_k127_1208883_7 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.000000000000000000000000000000000000000000000001608 175.0
TLS2_k127_1208883_8 dehydrogenase - - - 0.00000004774 55.0
TLS2_k127_1213892_0 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 2.201e-218 694.0
TLS2_k127_1213892_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 364.0
TLS2_k127_1213892_2 metal-dependent phosphoesterases (PHP family) K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 359.0
TLS2_k127_1213892_3 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 325.0
TLS2_k127_1213892_4 Belongs to the SUA5 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 309.0
TLS2_k127_1213892_5 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000005962 110.0
TLS2_k127_1242838_0 carbohydrate binding - - - 0.0 1584.0
TLS2_k127_1245085_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1059.0
TLS2_k127_1245085_1 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697,K03692 - 2.4.1.15,2.4.1.213,2.4.1.347 1.888e-253 805.0
TLS2_k127_1245085_2 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K00997,K01207 - 2.7.8.7,3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 508.0
TLS2_k127_1245085_3 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 343.0
TLS2_k127_1245085_4 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000009584 54.0
TLS2_k127_1254433_0 phosphate transport system K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003557 511.0
TLS2_k127_1254433_1 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007646 491.0
TLS2_k127_1254433_2 PBP superfamily domain K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004052 472.0
TLS2_k127_1254433_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005236 453.0
TLS2_k127_1254433_4 Glycosyltransferase Family 4 K00786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009415 449.0
TLS2_k127_1254433_5 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002289 237.0
TLS2_k127_1254433_6 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.0000000000000000000000000000000000000000000000000006602 186.0
TLS2_k127_1254433_7 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00001036 48.0
TLS2_k127_125484_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 583.0
TLS2_k127_125484_1 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 523.0
TLS2_k127_125484_2 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000564 395.0
TLS2_k127_125484_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008669 270.0
TLS2_k127_125484_4 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000001509 271.0
TLS2_k127_125484_5 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000001359 256.0
TLS2_k127_125484_6 PFAM TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000002163 192.0
TLS2_k127_1258491_0 Nickel-dependent hydrogenase K06281 - 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 373.0
TLS2_k127_1258491_1 Hydrogenase maturation protease K03605 - - 0.0000000000000000000000000000000000000000000000001269 181.0
TLS2_k127_1258491_2 [NiFe]-hydrogenase assembly, chaperone, HybE - - - 0.000000000000000000000000000000000004698 143.0
TLS2_k127_1258491_3 HupF/HypC family K04653 - - 0.0000000000000000008461 91.0
TLS2_k127_1258491_4 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.00000009216 58.0
TLS2_k127_126124_0 Selenocysteine synthase N terminal K01042 - 2.9.1.1 1.093e-204 646.0
TLS2_k127_126124_1 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 320.0
TLS2_k127_1279315_0 Parallel beta-helix repeats - - - 3.035e-245 805.0
TLS2_k127_1279315_1 histidine kinase, dimerisation and phosphoacceptor region - - - 0.000000000000000000000000000000000000000000000003491 192.0
TLS2_k127_1289864_0 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 312.0
TLS2_k127_1289864_1 Substrate binding domain of ABC-type glycine betaine transport system K02002 - - 0.0000000000000000000000000000000000000000000000000000000000000005207 224.0
TLS2_k127_1291176_0 PAS fold K10715,K20974 - 2.7.13.3 1.797e-237 777.0
TLS2_k127_1291176_1 response regulator receiver K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005756 466.0
TLS2_k127_1291176_2 Oxidoreductase FAD-binding domain K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 412.0
TLS2_k127_1291176_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006405 353.0
TLS2_k127_1291176_4 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000001376 246.0
TLS2_k127_1291176_5 FHA domain - - - 0.000000000000000000000000000000000000000000000001549 183.0
TLS2_k127_1291176_6 Protein of unknown function (DUF1631) - - - 0.00000009573 56.0
TLS2_k127_1293554_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 452.0
TLS2_k127_1293554_1 Squalene synthase HpnD K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 395.0
TLS2_k127_1293554_2 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA K06917 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 381.0
TLS2_k127_1293554_3 squalene-associated FAD-dependent desaturase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 382.0
TLS2_k127_1293554_4 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 327.0
TLS2_k127_1293554_5 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 305.0
TLS2_k127_1293554_6 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000005887 237.0
TLS2_k127_1300924_0 AsmA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 438.0
TLS2_k127_1300924_1 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002657 270.0
TLS2_k127_1300924_2 Large-conductance mechanosensitive channel, MscL - - - 0.00000000000000000000000000000000000000000000000000000000000001355 218.0
TLS2_k127_1300924_3 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000002832 49.0
TLS2_k127_1304714_0 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005702 526.0
TLS2_k127_1304714_1 Ammonium transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 421.0
TLS2_k127_1304714_2 crp fnr family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 373.0
TLS2_k127_1304714_3 phosphoserine phosphatase K02203 - 2.7.1.39,3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 334.0
TLS2_k127_1304714_4 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003642 269.0
TLS2_k127_1304714_5 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K06158 - - 0.0000000000000000000000000000000000000000000000000004171 188.0
TLS2_k127_1304714_6 Histidine kinase K07706,K15011 - 2.7.13.3 0.00000000000000000000000000000000000000006971 159.0
TLS2_k127_1312945_0 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009679 446.0
TLS2_k127_1312945_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004389 319.0
TLS2_k127_1312945_2 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000007274 141.0
TLS2_k127_1382085_0 ATPase (AAA superfamily K07133 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002784 594.0
TLS2_k127_1382085_1 SCO1/SenC K07152 - - 0.000000000000000000000000000000000000000000000000000000000002135 214.0
TLS2_k127_1382085_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000000000000000000000000000000002526 148.0
TLS2_k127_1382085_3 MotA/TolQ/ExbB proton channel family K03561 - - 0.00000000000000000000000000000000485 142.0
TLS2_k127_1399388_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008586 347.0
TLS2_k127_1399388_1 Glycolate oxidase subunit GlcD K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003667 312.0
TLS2_k127_1399388_2 - - - - 0.00000000000000000000000000003179 121.0
TLS2_k127_1399388_3 - - - - 0.0000006516 51.0
TLS2_k127_1414868_0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000002104 243.0
TLS2_k127_1414868_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000407 231.0
TLS2_k127_1414868_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000000001021 154.0
TLS2_k127_1414868_3 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.0000000000000000000000000000000001943 133.0
TLS2_k127_1423910_0 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second K01958 - 6.4.1.1 0.0 1212.0
TLS2_k127_1423910_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.00000000000000000000000000000000000002161 147.0
TLS2_k127_1434602_0 Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core K02848 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000779 414.0
TLS2_k127_1434602_1 Glycosyl transferases group 1 K02844 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 354.0
TLS2_k127_1434602_2 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 336.0
TLS2_k127_1446519_0 Poly-beta-1,6-N-acetyl-D-glucosamine synthase K11936 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006954 522.0
TLS2_k127_1446519_1 Tetratricopeptide repeats K11935 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004398 424.0
TLS2_k127_1446519_2 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004113 402.0
TLS2_k127_1446519_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000006894 226.0
TLS2_k127_1446519_4 TfoX N-terminal domain - - - 0.0000000000000006228 79.0
TLS2_k127_1446519_5 Lrp/AsnC ligand binding domain - - - 0.00000000000002961 74.0
TLS2_k127_1446519_6 PgaD-like protein - - - 0.000000004918 68.0
TLS2_k127_1463430_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 7.002e-300 931.0
TLS2_k127_1463430_1 serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 437.0
TLS2_k127_1463430_2 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 391.0
TLS2_k127_1463430_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 376.0
TLS2_k127_1463430_4 Stress-induced protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 343.0
TLS2_k127_1463430_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000821 299.0
TLS2_k127_1463430_6 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 300.0
TLS2_k127_1463430_7 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000000003333 103.0
TLS2_k127_1476195_0 COG1538 Outer membrane protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006546 465.0
TLS2_k127_1476195_1 3-Deoxy-D-manno-octulosonic-acid transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004747 453.0
TLS2_k127_1476195_10 Tfp pilus assembly protein FimV - - - 0.000000000000000000000000000000004624 148.0
TLS2_k127_1476195_11 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00002569 47.0
TLS2_k127_1476195_12 EamA-like transporter family - - - 0.0005888 46.0
TLS2_k127_1476195_2 Glycosyltransferase family 9 (heptosyltransferase) K02841 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 372.0
TLS2_k127_1476195_3 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 367.0
TLS2_k127_1476195_4 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 314.0
TLS2_k127_1476195_5 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 300.0
TLS2_k127_1476195_6 Heptaprenyl diphosphate synthase component I K00805 - 2.5.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000002554 245.0
TLS2_k127_1476195_7 NusG domain II - - - 0.000000000000000000000000000000000000000000003097 173.0
TLS2_k127_1476195_8 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000000000000000000000000000000000002964 147.0
TLS2_k127_1476195_9 PFAM Rhodanese domain protein - - - 0.0000000000000000000000000000000000003865 142.0
TLS2_k127_1500783_0 Acetokinase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007637 322.0
TLS2_k127_1500783_1 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second K01958 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004489 302.0
TLS2_k127_1508884_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0 1388.0
TLS2_k127_151096_0 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 606.0
TLS2_k127_151096_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 601.0
TLS2_k127_151096_2 COG0477 Permeases of the major facilitator superfamily K05820 - - 0.0000000000000000000000000000000000000000000000000000000000000334 218.0
TLS2_k127_151096_3 pilus assembly protein FimV K08086 - - 0.000000000000000000000000003042 115.0
TLS2_k127_154433_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003332 528.0
TLS2_k127_154433_1 mechanosensitive K05802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 313.0
TLS2_k127_154433_2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 284.0
TLS2_k127_154433_3 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.000000000000000000000000000000000000000000000003822 185.0
TLS2_k127_154433_4 Protein of unknown function (DUF3108) - - - 0.00000000000002484 85.0
TLS2_k127_1560421_0 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 2.753e-227 719.0
TLS2_k127_1560421_1 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 512.0
TLS2_k127_1560421_2 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009385 323.0
TLS2_k127_1560421_3 XdhC and CoxI family K07402 - - 0.0000000000000000000022 96.0
TLS2_k127_1569719_0 Acyl-CoA synthetase (NDP forming) K09181 - - 0.0 1223.0
TLS2_k127_1569719_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 446.0
TLS2_k127_1569719_2 Pfam Glycosyl transferase family 2 K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 370.0
TLS2_k127_1569719_3 YaeQ - - - 0.0000000000000000000000000000000000000000000000000000000000000004402 224.0
TLS2_k127_1569719_4 GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000001056 193.0
TLS2_k127_1569719_5 GtrA-like protein - - - 0.000000001363 64.0
TLS2_k127_1571804_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 3.308e-197 620.0
TLS2_k127_1571804_1 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 488.0
TLS2_k127_1571804_10 Sporulation related domain - - - 0.000000000000000003073 94.0
TLS2_k127_1571804_11 Protein of unknown function (DUF2802) - - - 0.0000000000003874 78.0
TLS2_k127_1571804_2 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000897 479.0
TLS2_k127_1571804_3 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 335.0
TLS2_k127_1571804_4 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002751 285.0
TLS2_k127_1571804_5 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000006666 203.0
TLS2_k127_1571804_6 endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000004251 194.0
TLS2_k127_1571804_7 TIGRFAM transcriptional regulator EpsA - - - 0.00000000000000000000000000000000000000000000000001988 189.0
TLS2_k127_1571804_8 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000005011 151.0
TLS2_k127_1571804_9 UDP-glucose 4-epimerase K01784 - 5.1.3.2 0.0000000000000000000001466 98.0
TLS2_k127_1580569_0 PAC sensor-containing diguanylate cyclase phosphodiesterase - - - 0.0 1039.0
TLS2_k127_1580569_1 Belongs to the thiolase family K00626 - 2.3.1.9 6.998e-215 673.0
TLS2_k127_1580569_2 Zn-dependent protease with chaperone function K06013 - 3.4.24.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 509.0
TLS2_k127_1580569_3 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008912 362.0
TLS2_k127_1580569_4 chemotaxis K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005332 362.0
TLS2_k127_1580569_5 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 336.0
TLS2_k127_1580569_6 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008054 317.0
TLS2_k127_1580569_7 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 290.0
TLS2_k127_1580569_8 COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000000003096 197.0
TLS2_k127_1580569_9 diol metabolic process K01724 - 4.2.1.96 0.000000000000000000000000000003522 123.0
TLS2_k127_1612453_0 COG0643 Chemotaxis protein histidine kinase and related kinases K02487,K06596 - - 0.0 1122.0
TLS2_k127_1612453_1 Acts as a magnesium transporter K06213 - - 2.706e-226 709.0
TLS2_k127_1612453_10 Chemotaxis signal transduction protein K02659 - - 0.00000000000000000000000000000000000000000000000000000002894 207.0
TLS2_k127_1612453_11 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000003813 207.0
TLS2_k127_1612453_12 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000003904 198.0
TLS2_k127_1612453_13 response regulator receiver K02658 - - 0.00000000000000000000000000000000000000000000000000002667 190.0
TLS2_k127_1612453_2 Aminotransferase K01845 - 5.4.3.8 6.97e-202 642.0
TLS2_k127_1612453_3 Methyl-accepting chemotaxis protein K02660 - - 6.939e-201 647.0
TLS2_k127_1612453_4 RNB K01147 - 3.1.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 517.0
TLS2_k127_1612453_5 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 413.0
TLS2_k127_1612453_6 Shikimate dehydrogenase substrate binding domain K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 329.0
TLS2_k127_1612453_7 TonB family K03832 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 321.0
TLS2_k127_1612453_8 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 294.0
TLS2_k127_1612453_9 RESPONSE REGULATOR receiver K02657 - - 0.000000000000000000000000000000000000000000000000000000000000007502 218.0
TLS2_k127_1719421_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1108.0
TLS2_k127_1719421_1 Participates in both transcription termination and antitermination K02600 - - 2.33e-242 756.0
TLS2_k127_1719421_2 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 347.0
TLS2_k127_1719421_3 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001647 282.0
TLS2_k127_1719421_4 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000000000000000000000000000000118 199.0
TLS2_k127_1719421_5 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000005367 48.0
TLS2_k127_1719421_6 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0002962 43.0
TLS2_k127_1761738_0 Cache domain K11527 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 501.0
TLS2_k127_1761738_1 - - - - 0.000000000000000000000000000000000000008566 156.0
TLS2_k127_1761738_2 Double zinc ribbon - - - 0.00001217 53.0
TLS2_k127_1765137_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 446.0
TLS2_k127_1765137_1 Iron-containing alcohol dehydrogenase K00001 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008311 340.0
TLS2_k127_1765137_2 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001664 287.0
TLS2_k127_1781388_0 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006471 357.0
TLS2_k127_1781388_1 Glutathione-dependent formaldehyde-activating K03396 - 4.4.1.22 0.0000000000000000000000000000000000000000000000000000000000000000005119 233.0
TLS2_k127_1781388_2 Dehydratase family K13875 - 4.2.1.25 0.0000000000000000000000000000000000000000000000606 169.0
TLS2_k127_1859307_0 PFAM NAD-dependent epimerase dehydratase K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006194 431.0
TLS2_k127_1859307_1 Belongs to the GPI family K01810 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 289.0
TLS2_k127_1874662_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001309 276.0
TLS2_k127_1874662_1 bacterial-type flagellum-dependent cell motility - - - 0.00000000000000001741 91.0
TLS2_k127_1888501_0 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000008403 228.0
TLS2_k127_1888501_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000003667 147.0
TLS2_k127_1888501_2 Domain of unknown function (DUF4437) - - - 0.0000000000000000000000000000003145 129.0
TLS2_k127_1888501_3 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.00000000000000000748 93.0
TLS2_k127_1888501_4 Psort location Cytoplasmic, score - - - 0.0000000000000001079 83.0
TLS2_k127_1888501_5 AAA domain - - - 0.000000001154 62.0
TLS2_k127_1888501_6 AAA domain - - - 0.00000001408 56.0
TLS2_k127_1895871_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 1.533e-213 671.0
TLS2_k127_1895871_1 Cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 322.0
TLS2_k127_1895871_2 PFAM Serine threonine protein kinase-related - - - 0.0000000000000000000000000000000000000000000000000000000000000000522 244.0
TLS2_k127_1895871_3 SURF1-like protein - - - 0.0000000000000000000000000000000002065 142.0
TLS2_k127_1895871_4 Protein of unknown function (DUF2909) - - - 0.00000003762 63.0
TLS2_k127_1898658_0 Peptidase family M48 - - - 2.238e-217 700.0
TLS2_k127_1898658_1 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 454.0
TLS2_k127_1898658_2 drug resistance transporter K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 340.0
TLS2_k127_1911588_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K12276 - - 1.395e-271 846.0
TLS2_k127_1911588_1 - - - - 0.0000000000000000000000000000000000001002 144.0
TLS2_k127_1911588_2 Type II secretion system (T2SS), protein F K02455,K12278 - - 0.0000000000000000000000000000001543 129.0
TLS2_k127_1911888_0 Belongs to the glycosyl hydrolase 43 family K01218,K19551 - 3.2.1.78,4.2.2.10,4.2.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 465.0
TLS2_k127_1911888_1 SIR2-like domain - - - 0.00000000000000000000000000000000000000000000008119 171.0
TLS2_k127_1911888_2 PFAM Hemerythrin HHE cation binding domain protein - - - 0.00000000000000000000000000000000000005011 152.0
TLS2_k127_1916871_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 8.059e-262 820.0
TLS2_k127_1928855_0 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005937 583.0
TLS2_k127_1928855_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 494.0
TLS2_k127_1928855_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002906 478.0
TLS2_k127_1928855_3 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 440.0
TLS2_k127_1928855_4 TonB-dependent Receptor Plug K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 369.0
TLS2_k127_1928855_5 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 348.0
TLS2_k127_1928855_6 cheY-homologous receiver domain K02485 - - 0.0000000000000000000000000000000000000000000000000000002776 199.0
TLS2_k127_1942076_0 ABC transporter transmembrane region K12541 - - 0.0 1022.0
TLS2_k127_1942076_1 HlyD family secretion protein K12542 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 591.0
TLS2_k127_1942076_2 luxR family - - - 0.0000000000000000000000000000000000000000008037 164.0
TLS2_k127_1942076_3 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.00000000000000000000000000001233 129.0
TLS2_k127_1942076_4 Outer membrane adhesin like proteiin - - - 0.00000000000000000000000000007807 126.0
TLS2_k127_1946411_0 Type II secretion system (T2SS), protein G K02456 - - 0.00000000000000000000000000000000000000000000000000000000000000163 221.0
TLS2_k127_1946411_1 Domain of unknown function (DUF4124) K08309 - - 0.000000000000000000000000000000000000000000000001446 183.0
TLS2_k127_1948360_0 FAD binding domain K00239,K00278 - 1.3.5.1,1.3.5.4,1.4.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 623.0
TLS2_k127_1948360_1 Parallel beta-helix repeats - - - 5.308e-195 622.0
TLS2_k127_1948360_2 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 564.0
TLS2_k127_1948360_3 Respiratory-chain NADH dehydrogenase 51 Kd subunit K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009681 510.0
TLS2_k127_1948360_4 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 478.0
TLS2_k127_1948360_5 Parallel beta-helix repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 397.0
TLS2_k127_1948360_6 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 374.0
TLS2_k127_1948360_7 2Fe-2S iron-sulfur cluster binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001032 239.0
TLS2_k127_1948360_8 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000000000000000000000000000000002287 188.0
TLS2_k127_19496_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 6.682e-282 889.0
TLS2_k127_19496_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 6.842e-222 698.0
TLS2_k127_19496_2 Rod shape-determining protein MreB K03569 - - 1.889e-207 648.0
TLS2_k127_19496_3 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 486.0
TLS2_k127_19496_4 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 449.0
TLS2_k127_19496_5 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006887 323.0
TLS2_k127_19496_6 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003902 296.0
TLS2_k127_19496_7 shape-determining protein K03571 - - 0.000000000000000000000000000000000000000000000000000000000000141 219.0
TLS2_k127_19496_8 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000002308 130.0
TLS2_k127_19496_9 PFAM Aminotransferase, class IV K00824 - 2.6.1.21 0.000004699 58.0
TLS2_k127_1975789_0 PAS PAC sensor signal transduction histidine kinase K05962 - 2.7.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000571 566.0
TLS2_k127_1975789_1 Part of a membrane complex involved in electron transport K03617 - - 0.000000000000000000000000000000000000000000000000000000000000000000002971 237.0
TLS2_k127_1979828_0 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 389.0
TLS2_k127_1979828_1 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002795 285.0
TLS2_k127_1979828_2 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.00000000000000000000000000000000000000000007564 170.0
TLS2_k127_1979828_3 LysE type translocator - - - 0.00000001832 56.0
TLS2_k127_2002946_0 carboxylase K01965 - 6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009153 415.0
TLS2_k127_2002946_1 Neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 398.0
TLS2_k127_2002946_2 Lactoylglutathione lyase K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 286.0
TLS2_k127_2002946_3 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.00000000000000000000000000000000000000000000000000000004178 206.0
TLS2_k127_2002946_4 His Kinase A (phosphoacceptor) domain - - - 0.00000001501 58.0
TLS2_k127_2004259_0 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 531.0
TLS2_k127_2004259_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 509.0
TLS2_k127_2004259_2 A G-specific K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004201 413.0
TLS2_k127_2004259_3 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 341.0
TLS2_k127_2004259_4 Eukaryotic-type carbonic anhydrase K01674 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000001714 208.0
TLS2_k127_2004259_5 Transcriptional regulator with HTH domain and aminotransferase domain containing protein - - - 0.000000000000000000003513 102.0
TLS2_k127_2027001_0 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009459 324.0
TLS2_k127_2027001_1 SCO1/SenC K07152 - - 0.000000000000000000000000000000000000000000000000004584 193.0
TLS2_k127_2027001_2 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000000000000000168 128.0
TLS2_k127_2036978_0 MOFRL family K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 559.0
TLS2_k127_2036978_1 Acyl-CoA synthetase (NDP forming) K09181 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 321.0
TLS2_k127_2036978_2 tellurite resistance protein - - - 0.00000000000000000000000000000000000000000000000000000000000000004387 229.0
TLS2_k127_2036978_3 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA K06917 - - 0.0000000000000000000000127 102.0
TLS2_k127_2049075_0 ABC transporter K15738 - - 1.585e-279 871.0
TLS2_k127_2049075_1 ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component K02004 - - 4.814e-262 832.0
TLS2_k127_2049075_10 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0009522 42.0
TLS2_k127_2049075_2 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 615.0
TLS2_k127_2049075_3 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 616.0
TLS2_k127_2049075_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005238 570.0
TLS2_k127_2049075_5 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007835 508.0
TLS2_k127_2049075_6 Belongs to the aconitase IPM isomerase family K01682 - 4.2.1.3,4.2.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 333.0
TLS2_k127_2049075_7 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000000000000000000000000000005437 141.0
TLS2_k127_2049075_8 TonB C terminal - - - 0.000000000000000000000000000000000009346 156.0
TLS2_k127_2049075_9 - - - - 0.0000000000002498 76.0
TLS2_k127_2052601_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 408.0
TLS2_k127_2052601_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 362.0
TLS2_k127_2052601_2 response regulator K14979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000759 300.0
TLS2_k127_2052601_3 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000002704 233.0
TLS2_k127_2052601_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000001841 223.0
TLS2_k127_2052601_5 PAS fold - - - 0.000000000000000000000000000000000000000000194 182.0
TLS2_k127_2052601_6 Type II secretory pathway, pseudopilin - - - 0.0000000000000000000000000137 112.0
TLS2_k127_2052601_7 AAA ATPase domain - - - 0.00000000000000000000000009833 124.0
TLS2_k127_2056469_0 B12 binding domain - - - 1.129e-297 919.0
TLS2_k127_2056469_1 Tryptophan halogenase - - - 1.441e-224 702.0
TLS2_k127_2056469_10 Protein of unknown function (DUF1615) - - - 0.000000000000000000000007878 117.0
TLS2_k127_2056469_2 Sodium hydrogen exchanger - - - 2.26e-215 673.0
TLS2_k127_2056469_3 Glycosyltransferase like family 2 K00786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 415.0
TLS2_k127_2056469_4 MltA-interacting protein MipA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000058 376.0
TLS2_k127_2056469_5 depolymerase K05973 - 3.1.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 385.0
TLS2_k127_2056469_6 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005087 364.0
TLS2_k127_2056469_7 pteridine-dependent deoxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 357.0
TLS2_k127_2056469_8 PAP2 superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007983 259.0
TLS2_k127_2056469_9 Phosphate acyltransferases - - - 0.0000000000000000000000000000000002322 144.0
TLS2_k127_2059441_0 Sulfatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008308 417.0
TLS2_k127_2059441_1 Predicted membrane protein (DUF2238) K08984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001894 278.0
TLS2_k127_2059441_2 cytochrome - - - 0.000000000000000000000000000000000000000001461 161.0
TLS2_k127_2059441_3 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000003205 142.0
TLS2_k127_2059441_4 hemolysin III K11068 - - 0.00000000000000008689 80.0
TLS2_k127_2085630_0 Exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 3.332e-204 662.0
TLS2_k127_2085630_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.171e-202 638.0
TLS2_k127_2085630_2 PFAM Enoyl-CoA hydratase isomerase - - - 0.0000000000000006139 87.0
TLS2_k127_20926_0 Ribonuclease E/G family K08301 - - 2.903e-221 707.0
TLS2_k127_20926_1 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001731 255.0
TLS2_k127_20926_2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000000000000001169 234.0
TLS2_k127_20926_3 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000000000000000000000000000000000001306 224.0
TLS2_k127_20926_4 dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000005662 212.0
TLS2_k127_20926_5 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000000000000000000001314 180.0
TLS2_k127_20926_6 - - - - 0.00000000000000000000000000000000000000007432 160.0
TLS2_k127_20926_7 Protein of unknown function (DUF2782) - - - 0.00000000000000000000000000000002062 129.0
TLS2_k127_20926_8 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000001387 91.0
TLS2_k127_2107037_0 Cytochrome c-type biogenesis protein CcmF C-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 613.0
TLS2_k127_2107037_1 oxidoreductase DsbE K02199 - - 0.0000000000000000000000000000000000000000000000000000007587 198.0
TLS2_k127_2107037_2 subunit of a heme lyase K02200 - - 0.0000000000000000000000000000004838 135.0
TLS2_k127_213155_0 A predicted alpha-helical domain with a conserved ER motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 407.0
TLS2_k127_213155_1 Circularly permuted ATP-grasp type 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006698 389.0
TLS2_k127_2136440_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 565.0
TLS2_k127_2136440_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 380.0
TLS2_k127_2136440_2 ABC-type (Unclassified) transport system, ATPase component K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 369.0
TLS2_k127_2136440_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 369.0
TLS2_k127_2136440_4 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000000000000000000000000000000000000000001163 214.0
TLS2_k127_2136440_5 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000000009212 202.0
TLS2_k127_2136440_6 Belongs to the CinA family K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000001634 192.0
TLS2_k127_2136440_7 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000002106 176.0
TLS2_k127_2136440_8 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000000000000000001669 168.0
TLS2_k127_2136440_9 Modulates RecA activity K03565 - - 0.00000000000000000000000000000000007948 147.0
TLS2_k127_2151345_0 ABC transporter K06158 - - 4.145e-316 972.0
TLS2_k127_2151345_1 RQC K03654 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005059 474.0
TLS2_k127_2163849_0 non-ribosomal peptide synthetase - - - 0.0 1269.0
TLS2_k127_2163849_1 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 3.481e-251 790.0
TLS2_k127_2163849_2 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 437.0
TLS2_k127_2163849_3 P-type ATPase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004785 275.0
TLS2_k127_2163849_4 - - - - 0.0000000000000000000001247 110.0
TLS2_k127_2220944_0 AMP-binding enzyme K00666 - - 8.065e-272 847.0
TLS2_k127_2220944_1 AraC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 440.0
TLS2_k127_2220944_2 diguanylate cyclase K21019 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000003088 216.0
TLS2_k127_2220944_3 3-hydroxyacyl-CoA dehydrogenase K07516 - 1.1.1.35 0.00000000000000000000000000000000000000000000000007029 179.0
TLS2_k127_2220944_4 LemA family K03744 - - 0.000000000000000000000000001201 114.0
TLS2_k127_222948_0 glutamate synthase, alpha subunit domain protein K00265 - 1.4.1.13,1.4.1.14 0.0 1360.0
TLS2_k127_222948_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 490.0
TLS2_k127_222948_2 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003118 488.0
TLS2_k127_222948_3 Type 4 fimbrial biogenesis protein K02666 - - 0.000000000000000000000000000000000000000000000000000000000000000000003465 238.0
TLS2_k127_222948_4 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000000000003902 208.0
TLS2_k127_2235104_0 Beta-Casp domain K07576 - - 1.117e-216 679.0
TLS2_k127_2235104_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000004048 250.0
TLS2_k127_2237723_0 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005833 437.0
TLS2_k127_2237723_1 - - - - 0.000000000000000000000000000000000000000000000000003595 192.0
TLS2_k127_2237723_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.000000000000000000000000000004574 123.0
TLS2_k127_2237723_3 Integral membrane protein (DUF2244) - - - 0.000000000000000002117 92.0
TLS2_k127_2238202_0 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000001229 267.0
TLS2_k127_2238202_1 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K21345 - 2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000005256 254.0
TLS2_k127_2238202_2 Crp Fnr family transcriptional regulator K21563 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005746 272.0
TLS2_k127_2238202_3 periplasmic or secreted lipoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000004185 226.0
TLS2_k127_2238202_4 Belongs to the heme-copper respiratory oxidase family - - - 0.0000000000000000000000000000000004237 139.0
TLS2_k127_2251244_0 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 578.0
TLS2_k127_2251244_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008263 351.0
TLS2_k127_2251244_2 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000000000001943 226.0
TLS2_k127_2251244_3 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000003088 171.0
TLS2_k127_2251244_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.0000000000000000000000000000009768 133.0
TLS2_k127_2254908_0 Tex-like protein N-terminal domain K06959 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - 4.471e-303 940.0
TLS2_k127_2254908_1 FAD dependent oxidoreductase K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 517.0
TLS2_k127_2254908_2 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000001856 223.0
TLS2_k127_22729_0 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006107 533.0
TLS2_k127_22729_1 - - - - 0.00000000000000000000001334 100.0
TLS2_k127_22729_2 Belongs to the radical SAM superfamily. RlmN family K06941 - 2.1.1.192 0.00001274 51.0
TLS2_k127_2273147_0 Acyl transferase domain in polyketide synthase (PKS) enzymes. - - - 0.0 1509.0
TLS2_k127_2273147_1 UDP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 377.0
TLS2_k127_2281864_0 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 312.0
TLS2_k127_2281864_1 TIGRFAM fructose-bisphosphate aldolase, class II, Calvin cycle subtype K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000002921 213.0
TLS2_k127_2286928_0 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - 3.556e-229 737.0
TLS2_k127_2286928_1 COG0569 K transport systems, NAD-binding component K03499 - - 2.96e-209 660.0
TLS2_k127_2286928_10 Domain of unknown function (DUF4390) - - - 0.000000000000000000000000000000000000000000324 164.0
TLS2_k127_2286928_11 Belongs to the Smg family K03747 - - 0.00000000000000000000000000000000000001327 153.0
TLS2_k127_2286928_2 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 520.0
TLS2_k127_2286928_3 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 492.0
TLS2_k127_2286928_4 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006024 437.0
TLS2_k127_2286928_5 DNA recombination-mediator protein A K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006305 427.0
TLS2_k127_2286928_6 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 408.0
TLS2_k127_2286928_7 protein containing LysM domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 327.0
TLS2_k127_2286928_8 DNA topoisomerase K03169 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 300.0
TLS2_k127_2286928_9 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000007917 246.0
TLS2_k127_2288222_0 Bacterial extracellular solute-binding protein K02055 - - 8.706e-196 626.0
TLS2_k127_2288222_1 Binding-protein-dependent transport system inner membrane component K02054 - - 0.000000000001558 68.0
TLS2_k127_2293938_0 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006652 606.0
TLS2_k127_2293938_1 Radical SAM K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006668 598.0
TLS2_k127_2293938_10 Dienelactone hydrolase - - - 0.00000000000000000000000000000000006281 142.0
TLS2_k127_2293938_2 Protein of unknown function (DUF1501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 518.0
TLS2_k127_2293938_3 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 488.0
TLS2_k127_2293938_4 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 464.0
TLS2_k127_2293938_5 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 311.0
TLS2_k127_2293938_6 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002828 280.0
TLS2_k127_2293938_7 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000785 246.0
TLS2_k127_2293938_8 ferrous iron binding K06990,K09141 - - 0.0000000000000000000000000000000000000000000000000000000000000008757 228.0
TLS2_k127_2293938_9 Flavocytochrome c sulphide dehydrogenase, flavin-binding K17229 - 1.8.2.3 0.0000000000000000000000000000000000000000000000000000004159 200.0
TLS2_k127_2295263_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 566.0
TLS2_k127_2295263_1 D-ala D-ala ligase N-terminus K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 416.0
TLS2_k127_2295263_2 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 351.0
TLS2_k127_2295263_3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002244 250.0
TLS2_k127_2295263_4 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000003364 196.0
TLS2_k127_2302339_0 PFAM NapC NirT cytochrome c K02569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004595 317.0
TLS2_k127_2302339_1 Electron transfer subunit of the periplasmic nitrate reductase complex NapAB K02568 - - 0.0000000000000000000000000000000000000000000000000009334 188.0
TLS2_k127_2302339_2 NMT1-like family - - - 0.00000000000000000000000000000000000000001009 157.0
TLS2_k127_2303948_0 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 539.0
TLS2_k127_2303948_1 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 458.0
TLS2_k127_2303948_2 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 418.0
TLS2_k127_2303948_3 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002859 281.0
TLS2_k127_2303948_4 had-superfamily hydrolase subfamily ia, variant 3 K07025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004017 292.0
TLS2_k127_2303948_5 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.00000000000000000000000000000000000000000000000000000000000000000000000008491 263.0
TLS2_k127_2303948_6 cytochrome - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002963 253.0
TLS2_k127_2303948_7 Bacterial regulatory proteins, tetR family K05501 - - 0.000000000000000000000000000000000000000000000000000000000000000000005993 249.0
TLS2_k127_2303948_8 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.000000000000000000000000000000000000000000000000000000000000000004086 231.0
TLS2_k127_2310011_0 MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 349.0
TLS2_k127_2310011_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000002384 150.0
TLS2_k127_2310011_2 thioesterase K07107 - - 0.000000000000000000000000000000000000003264 154.0
TLS2_k127_2310011_3 Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000003096 92.0
TLS2_k127_231188_0 TonB dependent receptor K02014 - - 4.212e-298 931.0
TLS2_k127_231188_1 Biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 3.877e-262 813.0
TLS2_k127_231188_10 acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000003493 211.0
TLS2_k127_231188_11 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000000000000000000000000004676 199.0
TLS2_k127_231188_12 - - - - 0.0000000000000000000000000000000000000000000000000000002068 200.0
TLS2_k127_231188_13 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000004789 189.0
TLS2_k127_231188_14 zinc-ribbon domain - - - 0.00000000000000000000000000000000000000000001563 179.0
TLS2_k127_231188_15 - - - - 0.000000000000000000000279 102.0
TLS2_k127_231188_2 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 1.576e-215 676.0
TLS2_k127_231188_3 COG0524 Sugar kinases, ribokinase family K00856 - 2.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 497.0
TLS2_k127_231188_4 RNA polymerase sigma K03089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 399.0
TLS2_k127_231188_5 Ribosomal protein L11 methyltransferase K02687 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 385.0
TLS2_k127_231188_6 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009512 371.0
TLS2_k127_231188_7 NosL - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009131 267.0
TLS2_k127_231188_8 lipoprotein involved in nitrous oxide reduction - - - 0.00000000000000000000000000000000000000000000000000000000000000000004377 237.0
TLS2_k127_231188_9 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000001549 216.0
TLS2_k127_2314437_0 DNA segregation ATPase FtsK SpoIIIE K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000386 551.0
TLS2_k127_2314437_1 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.00000000000000000000000000000000000000000000000000000000000000002394 230.0
TLS2_k127_2314437_2 excinuclease, ATPase subunit - - - 0.0001358 49.0
TLS2_k127_2317943_0 MFS/sugar transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 562.0
TLS2_k127_2317943_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005424 394.0
TLS2_k127_2317943_2 Protein of unknown function (DUF3833) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 331.0
TLS2_k127_2317943_3 SnoaL-like domain K01822 - 5.3.3.1 0.0000000000000000000000000000000000000000000000001232 181.0
TLS2_k127_2317943_4 Chalcone isomerase-like - - - 0.0000000000000000000000000005952 113.0
TLS2_k127_2322395_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009369 384.0
TLS2_k127_2322395_1 Dinitrogenase iron-molybdenum cofactor K02585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 336.0
TLS2_k127_2322395_2 transcriptional K03719 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001607 263.0
TLS2_k127_2322395_3 hydratase decarboxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008005 268.0
TLS2_k127_232476_0 chorismate mutase K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 500.0
TLS2_k127_232476_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004049 392.0
TLS2_k127_232476_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005681 362.0
TLS2_k127_2338646_0 TonB dependent receptor K02014 - - 7.211e-223 713.0
TLS2_k127_2338646_1 Histidine kinase K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 496.0
TLS2_k127_2338646_10 - K09892 - - 0.000001032 53.0
TLS2_k127_2338646_11 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs K05541 - - 0.0005692 43.0
TLS2_k127_2338646_2 Periplasmic binding protein domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 481.0
TLS2_k127_2338646_3 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 426.0
TLS2_k127_2338646_4 Cob(II)yrinic acid a,c-diamide reductase K02303,K04719 - 1.13.11.79,2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007397 341.0
TLS2_k127_2338646_5 COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 319.0
TLS2_k127_2338646_6 membrane transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005047 276.0
TLS2_k127_2338646_7 EVE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002985 256.0
TLS2_k127_2338646_9 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000000000000004584 111.0
TLS2_k127_2369509_0 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 447.0
TLS2_k127_2369509_1 Hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 368.0
TLS2_k127_2369509_2 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002288 256.0
TLS2_k127_2369509_3 Belongs to the DnaA family K10763 - - 0.000000000000000000000000000000000000000000000000000000003161 216.0
TLS2_k127_2382504_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005881 604.0
TLS2_k127_2382504_1 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009468 301.0
TLS2_k127_2382504_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 296.0
TLS2_k127_2382504_3 PFAM Rhodanese domain protein - - - 0.00002077 52.0
TLS2_k127_2382504_4 cyclic nucleotide binding K01420,K21563 - - 0.00009437 51.0
TLS2_k127_24032_0 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 9.313e-236 736.0
TLS2_k127_24032_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 377.0
TLS2_k127_24032_2 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005038 354.0
TLS2_k127_24032_3 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 317.0
TLS2_k127_24032_4 MotA TolQ ExbB proton channel K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 291.0
TLS2_k127_24032_5 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000001927 212.0
TLS2_k127_24032_6 Biopolymer transport protein K03559 - - 0.000000000000000000000000000000000000000000000000000001033 199.0
TLS2_k127_24032_7 Belongs to the UPF0434 family K09791 - - 0.00000000000003877 74.0
TLS2_k127_2409274_0 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 427.0
TLS2_k127_2409274_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 323.0
TLS2_k127_2409274_2 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 286.0
TLS2_k127_2409274_3 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000004577 239.0
TLS2_k127_2409274_4 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000002288 214.0
TLS2_k127_2409274_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000001292 98.0
TLS2_k127_2409274_6 ABC transporter K01996 - - 0.00000000000009058 70.0
TLS2_k127_2427831_0 receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000174 282.0
TLS2_k127_2427831_2 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.0000000000001203 83.0
TLS2_k127_2427831_3 - - - - 0.0000008162 61.0
TLS2_k127_2455514_0 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 369.0
TLS2_k127_2455514_1 Predicted membrane protein (DUF2157) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001297 257.0
TLS2_k127_2455514_2 TM2 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001194 243.0
TLS2_k127_2473355_0 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 1094.0
TLS2_k127_2473355_1 glutamate synthase K00266 - 1.4.1.13,1.4.1.14 5.03e-261 810.0
TLS2_k127_2473355_2 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000001925 259.0
TLS2_k127_2494835_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 6.522e-284 877.0
TLS2_k127_2494835_1 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007502 452.0
TLS2_k127_2494835_10 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000001469 70.0
TLS2_k127_2494835_11 ATP synthase I chain K02116 - - 0.000000000001824 73.0
TLS2_k127_2494835_2 involved in chromosome partitioning K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005181 421.0
TLS2_k127_2494835_3 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006996 397.0
TLS2_k127_2494835_4 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 296.0
TLS2_k127_2494835_5 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000000000000000000007775 225.0
TLS2_k127_2494835_6 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000000000000000000000000001878 211.0
TLS2_k127_2494835_7 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000002357 197.0
TLS2_k127_2494835_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000000002951 166.0
TLS2_k127_2494835_9 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000000000000000001712 148.0
TLS2_k127_2517424_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1236.0
TLS2_k127_2517424_1 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 566.0
TLS2_k127_2517424_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.000000000000000000000000009142 110.0
TLS2_k127_2517424_3 Belongs to the ompA family K03286 - - 0.00005057 48.0
TLS2_k127_254560_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1030.0
TLS2_k127_254560_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 8.457e-268 835.0
TLS2_k127_254560_10 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000913 418.0
TLS2_k127_254560_11 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006295 404.0
TLS2_k127_254560_12 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 406.0
TLS2_k127_254560_13 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 355.0
TLS2_k127_254560_14 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 322.0
TLS2_k127_254560_15 Sigma E regulatory protein, MucB RseB K03598 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006858 294.0
TLS2_k127_254560_16 Uroporphyrin-III C tetrapyrrole K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006634 284.0
TLS2_k127_254560_17 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002412 281.0
TLS2_k127_254560_18 Ribonuclease III family K03685 - 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002065 274.0
TLS2_k127_254560_19 HAD-superfamily hydrolase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001464 272.0
TLS2_k127_254560_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 4.364e-237 738.0
TLS2_k127_254560_20 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005071 258.0
TLS2_k127_254560_21 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000000000000000002075 153.0
TLS2_k127_254560_22 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000000000005815 137.0
TLS2_k127_254560_23 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000000000000002299 121.0
TLS2_k127_254560_24 metal-binding, possibly nucleic acid-binding protein K07040 - - 0.000000000000000000000000000989 118.0
TLS2_k127_254560_25 Domain of unknown function (DUF4845) - - - 0.000000000000000000000001162 109.0
TLS2_k127_254560_26 Glutaredoxin-like domain (DUF836) - - - 0.00000000000000000000000172 110.0
TLS2_k127_254560_27 Anti sigma-E protein RseA, N-terminal domain K03597 - - 0.0000000002017 69.0
TLS2_k127_254560_28 Positive regulator of sigma(E), RseC/MucC - - - 0.00000002794 61.0
TLS2_k127_254560_29 - K19168 - - 0.00008968 50.0
TLS2_k127_254560_3 Belongs to the peptidase S1C family K04771 - 3.4.21.107 3.346e-216 680.0
TLS2_k127_254560_4 7TM diverse intracellular signalling - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002932 579.0
TLS2_k127_254560_5 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 482.0
TLS2_k127_254560_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005384 471.0
TLS2_k127_254560_7 signal peptide peptidase K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 441.0
TLS2_k127_254560_8 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 426.0
TLS2_k127_254560_9 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 424.0
TLS2_k127_2572525_0 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007391 360.0
TLS2_k127_2572525_1 COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 333.0
TLS2_k127_2572525_2 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000000000001996 175.0
TLS2_k127_2572525_3 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.0000000000001808 70.0
TLS2_k127_2618566_0 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 595.0
TLS2_k127_2618566_1 Peptidase U32 K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 573.0
TLS2_k127_2618566_2 Peptidase family U32 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 371.0
TLS2_k127_2618566_3 VanZ like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002018 273.0
TLS2_k127_2618566_4 lipid carrier protein - - - 0.000000000000000000000000000000000000000000001846 178.0
TLS2_k127_2618566_5 AAA domain K07028 - - 0.000000000000000000000000000000000000000000003611 169.0
TLS2_k127_2618566_6 Ferredoxin - - - 0.000000000000000000000000000000000000000000004851 165.0
TLS2_k127_2618566_7 Nucleotide pyrophosphohydrolase - - - 0.000000000000000000000000000000000001248 141.0
TLS2_k127_2618566_8 hydrolase of the alpha beta superfamily K07018 - - 0.0000001495 60.0
TLS2_k127_2657102_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 8.747e-197 625.0
TLS2_k127_2657102_1 Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway K03181 - 4.1.3.40 0.0000000000000002096 83.0
TLS2_k127_2737857_0 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001582 263.0
TLS2_k127_2737857_1 COG4963 Flp pilus assembly protein ATPase CpaE K02282 - - 0.000000000000000000000000000000000005289 143.0
TLS2_k127_2737857_2 PFAM TadE family protein - - - 0.0000000000000000000000000000001038 132.0
TLS2_k127_2737857_3 TadE-like protein - - - 0.0000000000000000000000002373 112.0
TLS2_k127_2753841_0 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 7.924e-258 810.0
TLS2_k127_2753841_1 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 541.0
TLS2_k127_2753841_2 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 516.0
TLS2_k127_2753841_3 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 441.0
TLS2_k127_2753841_4 MraZ protein, putative antitoxin-like K03925 - - 0.00000000000000000000000000000000000000000000000000000000000000006085 225.0
TLS2_k127_2753841_5 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.00000000000000000000007094 100.0
TLS2_k127_2753841_6 PKD domain - - - 0.0001475 44.0
TLS2_k127_277673_0 catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0 1013.0
TLS2_k127_277673_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 434.0
TLS2_k127_277673_2 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009966 293.0
TLS2_k127_277673_3 GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000001027 213.0
TLS2_k127_277673_4 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000001586 215.0
TLS2_k127_2781107_0 Sodium/hydrogen exchanger family - - - 1.17e-199 630.0
TLS2_k127_2781107_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 561.0
TLS2_k127_2781107_11 BON domain - - - 0.00000000000000000000003683 103.0
TLS2_k127_2781107_12 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000004916 96.0
TLS2_k127_2781107_2 crp fnr family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 400.0
TLS2_k127_2781107_3 Crp-like helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008657 319.0
TLS2_k127_2781107_4 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 298.0
TLS2_k127_2781107_5 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 286.0
TLS2_k127_2781107_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007284 258.0
TLS2_k127_2781107_7 6-phosphogluconolactonase K00851,K01057 - 2.7.1.12,3.1.1.31 0.00000000000000000000000000000000000000000000000000000000001916 222.0
TLS2_k127_2781107_8 NAD(P)H-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000006451 181.0
TLS2_k127_2781107_9 Belongs to the ompA family K03286 - - 0.00000000000000000000000000000000000000000000000006112 187.0
TLS2_k127_2807626_0 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 2.205e-239 756.0
TLS2_k127_2807626_1 Glucose / Sorbosone dehydrogenase - - - 1.066e-232 731.0
TLS2_k127_2807626_10 Alternative oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007948 293.0
TLS2_k127_2807626_11 protein, hemolysin III K11068 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 290.0
TLS2_k127_2807626_12 Prokaryotic cytochrome b561 K12262 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004322 273.0
TLS2_k127_2807626_13 PRC-barrel domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001982 228.0
TLS2_k127_2807626_14 - - - - 0.0000000000000000000000000000000000000000000000000000004393 198.0
TLS2_k127_2807626_15 NADPH-dependent FMN reductase K19784 - - 0.0000000000000000000000000000000000000000000000000000009749 194.0
TLS2_k127_2807626_16 Domain of unknown function (DUF1772) - - - 0.00000000000000000000000000000000000000000000005639 173.0
TLS2_k127_2807626_17 Periplasmic or secreted lipoprotein - - - 0.0000000000000000000000000000000000000000002953 160.0
TLS2_k127_2807626_18 MerR HTH family regulatory protein K18997 - - 0.000000000000000000000000000001879 123.0
TLS2_k127_2807626_19 Transcriptional regulator K13643 - - 0.000000000000000000000000002958 119.0
TLS2_k127_2807626_2 Putative diguanylate phosphodiesterase - - - 1.358e-195 625.0
TLS2_k127_2807626_20 - - - - 0.00000000000000000000001341 101.0
TLS2_k127_2807626_21 ribosome binding K05594 - - 0.00000000000000000000004515 103.0
TLS2_k127_2807626_23 Protein of unknown function (DUF3309) - - - 0.00000000000000000002416 93.0
TLS2_k127_2807626_24 - - - - 0.000000000000005283 81.0
TLS2_k127_2807626_25 CsbD-like - - - 0.0000000958 58.0
TLS2_k127_2807626_26 Protein of unknown function (DUF3096) - - - 0.000002198 52.0
TLS2_k127_2807626_3 carbohydrate binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 593.0
TLS2_k127_2807626_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616,K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 537.0
TLS2_k127_2807626_5 DnaJ molecular chaperone homology domain K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 464.0
TLS2_k127_2807626_6 PFAM alpha beta hydrolase fold K00433 - 1.11.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 422.0
TLS2_k127_2807626_7 glyoxalase III activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 403.0
TLS2_k127_2807626_8 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 326.0
TLS2_k127_2807626_9 cell septum assembly - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002869 307.0
TLS2_k127_2813423_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0 1037.0
TLS2_k127_2813423_1 Two-component sensor kinase N-terminal K07649 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 548.0
TLS2_k127_2813423_2 Sodium:solute symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 356.0
TLS2_k127_2813423_3 Transcriptional regulatory protein, C terminal K07666 - - 0.000000000000000000000000000000000000000000003966 173.0
TLS2_k127_2813423_4 Domain of unknown function (DUF4212) - - - 0.00000000000000000000000000000000000000002847 155.0
TLS2_k127_2813423_5 Domain of unknown function (DUF4212) - - - 0.000000000000000000000000000000000008791 137.0
TLS2_k127_2822600_0 Dynamin family - - - 1.342e-201 649.0
TLS2_k127_2822600_1 Belongs to the peptidase M16 family K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003131 586.0
TLS2_k127_2822600_2 Peptidase M16 K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 501.0
TLS2_k127_2822600_3 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005709 312.0
TLS2_k127_2822600_4 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001054 255.0
TLS2_k127_2822600_5 methyltransferase K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000000000000000000006995 219.0
TLS2_k127_2822600_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000001197 192.0
TLS2_k127_2822600_7 Ferredoxin - - - 0.0000000000000000000000000000000000000000002949 158.0
TLS2_k127_2822600_8 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000491 158.0
TLS2_k127_2831793_0 cation transport ATPase K01533 - 3.6.3.4 0.0 1012.0
TLS2_k127_2831793_1 Cytochrome C and Quinol oxidase polypeptide I K00404 - 1.9.3.1 5.224e-282 869.0
TLS2_k127_2831793_10 COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 324.0
TLS2_k127_2831793_11 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004203 296.0
TLS2_k127_2831793_12 Universal stress protein - - - 0.000000000000000000000000000000000000000000000000000000000001224 214.0
TLS2_k127_2831793_13 Hemerythrin HHE cation binding - - - 0.0000000000000000000000000000000000000000000003381 173.0
TLS2_k127_2831793_14 FixH K09926 - - 0.0000000000000000000000000000000000008198 147.0
TLS2_k127_2831793_15 Type IV minor pilin ComP, DNA uptake sequence receptor K02655 - - 0.00000000000000000000000000000000001573 144.0
TLS2_k127_2831793_16 Type II transport protein GspH K08084 - - 0.0000000000000000000000000001944 122.0
TLS2_k127_2831793_17 cytochrome oxidase maturation protein cbb3-type - - - 0.0000000000000001124 81.0
TLS2_k127_2831793_18 Cbb3-type cytochrome oxidase K00407 - - 0.000000000003081 69.0
TLS2_k127_2831793_19 Protein of unknown function (DUF3149) - - - 0.000000001843 59.0
TLS2_k127_2831793_2 Poly-beta-hydroxybutyrate K03821 - - 1.203e-260 815.0
TLS2_k127_2831793_3 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 2.097e-238 746.0
TLS2_k127_2831793_4 2-nitropropane dioxygenase - - - 1.055e-225 704.0
TLS2_k127_2831793_5 Cytochrome C oxidase accessory protein - - - 1.724e-204 647.0
TLS2_k127_2831793_6 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 612.0
TLS2_k127_2831793_7 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003999 402.0
TLS2_k127_2831793_8 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006051 382.0
TLS2_k127_2831793_9 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005026 344.0
TLS2_k127_2836685_0 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001106 243.0
TLS2_k127_2836685_1 Tetratricopeptide repeat K12284 - - 0.0000000000000000000000001273 115.0
TLS2_k127_2842951_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 0.0 1007.0
TLS2_k127_2842951_1 fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 430.0
TLS2_k127_2842951_2 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000007443 261.0
TLS2_k127_2842951_3 Succinate dehydrogenase, hydrophobic K00242 - - 0.00000000000000000000000000000002642 126.0
TLS2_k127_2842951_4 Flavinator of succinate dehydrogenase K09159 - - 0.0000000000001772 72.0
TLS2_k127_2851274_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004037 357.0
TLS2_k127_2851274_1 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000001033 216.0
TLS2_k127_2851274_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.00000000000000000000000000000000000000003955 151.0
TLS2_k127_2851274_3 - - - - 0.00000000000000000000000001761 116.0
TLS2_k127_2861869_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004313 410.0
TLS2_k127_2861869_1 Proton-conducting membrane transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 396.0
TLS2_k127_2861869_2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA K04651 - - 0.0000000000000000000000000000000000000000000000002908 179.0
TLS2_k127_2861869_3 Hydrogenase accessory protein HypB K04652 - - 0.000001052 51.0
TLS2_k127_2873612_0 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 3.941e-218 696.0
TLS2_k127_2873612_1 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001345 267.0
TLS2_k127_2873612_2 cell division K09812 - - 0.0000000000000000000000000000000000000000000000000003658 187.0
TLS2_k127_2873612_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000001263 91.0
TLS2_k127_2873612_4 VanZ like family - - - 0.00000000000000002709 86.0
TLS2_k127_2877199_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005472 456.0
TLS2_k127_2877199_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 383.0
TLS2_k127_2877199_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000005881 260.0
TLS2_k127_2877199_3 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.000000000000000000000004545 109.0
TLS2_k127_2879490_0 poly(R)-hydroxyalkanoic acid synthase K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 419.0
TLS2_k127_2879490_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 404.0
TLS2_k127_2879490_2 transcriptional - - - 0.00000000000000000000000000000001136 130.0
TLS2_k127_2883080_0 serine acetyltransferase K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008207 403.0
TLS2_k127_2883080_1 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000192 280.0
TLS2_k127_2883080_2 Rrf2 family transcriptional regulator, iron-sulfur cluster assembly K13643 - - 0.00000000000000000000000000000000000000000000000000000000000004579 218.0
TLS2_k127_2883080_3 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000001648 89.0
TLS2_k127_2911824_0 Nitrogenase component 1 type Oxidoreductase K02587 - - 1.28e-247 773.0
TLS2_k127_2911824_1 Diguanylate cyclase - - - 3.09e-227 739.0
TLS2_k127_2911824_2 Periplasmic binding proteins and sugar binding domain of LacI family K10439 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 332.0
TLS2_k127_2911824_3 Circularly permuted ATP-grasp type 2 - - - 0.0000000000000000000000000000000000000000000006728 170.0
TLS2_k127_2911824_4 Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria - - - 0.0000000958 58.0
TLS2_k127_2925104_0 Aspartate ammonia-lyase K01744 - 4.3.1.1 1.188e-228 715.0
TLS2_k127_2925104_1 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000046 222.0
TLS2_k127_2928742_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 542.0
TLS2_k127_2928742_1 DinB superfamily - - - 0.000000000000000000000000000000000000000000007087 166.0
TLS2_k127_2931989_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 3.716e-290 898.0
TLS2_k127_2931989_1 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 494.0
TLS2_k127_2931989_2 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000000000000000000008499 187.0
TLS2_k127_2950214_0 Histidine kinase K07637 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 375.0
TLS2_k127_2950214_1 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress K05916,K07006,K21832 - 1.14.12.17 0.00000000000000000000000000000000000000000000000000000000000001445 223.0
TLS2_k127_2960905_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.0 1001.0
TLS2_k127_2960905_1 Domain of unknown function (DUF3391) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007267 588.0
TLS2_k127_2960905_2 Domain of unknown function (DUF4143) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 500.0
TLS2_k127_2960905_3 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 450.0
TLS2_k127_2960905_4 RNB K01147 - 3.1.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007911 416.0
TLS2_k127_2960905_5 Uncharacterised protein family (UPF0227) K07000 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008267 263.0
TLS2_k127_2960905_6 PFAM PEBP family protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000000000005831 229.0
TLS2_k127_2960905_7 Domain of unknown function (DUF4124) - - - 0.0000000002795 68.0
TLS2_k127_2979929_0 Periplasmic binding protein K01999 - - 1.299e-245 784.0
TLS2_k127_2979929_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005514 602.0
TLS2_k127_2979929_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 535.0
TLS2_k127_2979929_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 473.0
TLS2_k127_2979929_4 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000006991 119.0
TLS2_k127_2979929_5 AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000003825 90.0
TLS2_k127_2981456_0 PFAM Thiamine pyrophosphate K00170,K18356 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 572.0
TLS2_k127_2981456_1 pyruvate flavodoxin ferredoxin oxidoreductase K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000047 280.0
TLS2_k127_2981456_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.000000000000000000000000000000000000000000000000000000000000000003482 245.0
TLS2_k127_2990078_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454,K02652 - - 5.048e-233 727.0
TLS2_k127_2990078_1 PFAM type II and III secretion system protein K02453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 330.0
TLS2_k127_2990078_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000001408 219.0
TLS2_k127_2998919_0 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 593.0
TLS2_k127_2998919_1 Cytochrome c-type biogenesis protein K02200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 301.0
TLS2_k127_2998919_2 oxidoreductase DsbE K02199 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004561 265.0
TLS2_k127_2998919_3 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000000000000000001016 168.0
TLS2_k127_2998919_4 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000000000003188 170.0
TLS2_k127_2998919_5 Protein of unknown function (DUF3460) - - - 0.000000000000000001979 91.0
TLS2_k127_3010987_0 Domain of unknown function (DUF3391) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007155 417.0
TLS2_k127_3010987_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.00000000000000000000000000000000000001034 145.0
TLS2_k127_3010987_2 - - - - 0.00000000000001914 79.0
TLS2_k127_3041886_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1066.0
TLS2_k127_3041886_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 1.61e-241 762.0
TLS2_k127_3041886_2 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 5.041e-234 732.0
TLS2_k127_3041886_3 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000008964 211.0
TLS2_k127_3041886_4 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000000000000000009481 126.0
TLS2_k127_3060942_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 3.039e-222 695.0
TLS2_k127_3060942_1 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000004469 69.0
TLS2_k127_3063158_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 4.615e-229 711.0
TLS2_k127_3063158_1 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000002065 201.0
TLS2_k127_3063158_3 - - - - 0.00000000000000000000000000000006092 127.0
TLS2_k127_3063158_4 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.0000000000000000000000000000001183 131.0
TLS2_k127_3063158_5 - - - - 0.0000000000000000000000001193 111.0
TLS2_k127_3077594_0 Heat shock 70 kDa protein K04043 - - 0.0 1088.0
TLS2_k127_3077594_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 4.756e-209 653.0
TLS2_k127_3077594_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000001875 224.0
TLS2_k127_3077594_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000000000000000000000003283 208.0
TLS2_k127_3077594_4 Sel1-like repeats. - - - 0.000000002465 63.0
TLS2_k127_3090099_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 4.567e-195 611.0
TLS2_k127_3090099_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 432.0
TLS2_k127_3090099_2 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 339.0
TLS2_k127_3090099_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000562 316.0
TLS2_k127_3090099_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 295.0
TLS2_k127_3090099_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000006117 212.0
TLS2_k127_3090099_6 preprotein translocase K03075 - - 0.000000000000000000000000000000000000000008776 156.0
TLS2_k127_3109804_0 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 418.0
TLS2_k127_3109804_1 Phosphotransferase system, mannose fructose-specific component IIA K02821 - 2.7.1.194 0.000000000000000000000000000000000000000000000000000298 196.0
TLS2_k127_3109804_2 Protein of unknown function (DUF3050) - - - 0.0000000000000000000000000000000000365 136.0
TLS2_k127_3109804_3 - - - - 0.0000000000000000000000000000000001654 137.0
TLS2_k127_3109804_4 - - - - 0.00000000000000000000000000000000023 139.0
TLS2_k127_3109804_5 Phosphotransferase System K11189 - - 0.0000000000000000000000922 98.0
TLS2_k127_3109804_6 - - - - 0.000000000000000000002138 99.0
TLS2_k127_3129956_0 COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) K00336 - 1.6.5.3 1.928e-257 808.0
TLS2_k127_3129956_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 291.0
TLS2_k127_3152492_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 397.0
TLS2_k127_3152492_1 Putative transposase of IS4/5 family (DUF4096) K07492 - - 0.000000000000000000000000000000000000000000000000000000000000000001437 229.0
TLS2_k127_3152492_2 Transposase DDE domain - - - 0.000000000000000000000000000000000000000000000000000000008394 201.0
TLS2_k127_3159074_0 Major Facilitator - - - 9.069e-209 655.0
TLS2_k127_3159074_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 419.0
TLS2_k127_3159074_2 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005912 418.0
TLS2_k127_3159074_3 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008384 306.0
TLS2_k127_3159074_4 Pfam:TPM - - - 0.000000000000000000000000000000000000000000000000000001226 198.0
TLS2_k127_3183205_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 7.646e-220 687.0
TLS2_k127_3183205_1 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 408.0
TLS2_k127_3183205_10 NTP binding protein (Contains STAS domain) K04749,K07122 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716 - 0.000000003467 63.0
TLS2_k127_3183205_2 abc transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006608 405.0
TLS2_k127_3183205_3 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 354.0
TLS2_k127_3183205_4 VacJ family lipoprotein K04754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 321.0
TLS2_k127_3183205_5 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 306.0
TLS2_k127_3183205_6 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001768 301.0
TLS2_k127_3183205_7 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000003549 274.0
TLS2_k127_3183205_8 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008888 252.0
TLS2_k127_3183205_9 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000000000000000000000000000000000000000000000000000000000004329 222.0
TLS2_k127_3186826_0 Mate efflux family protein K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007476 323.0
TLS2_k127_3186826_1 chemotaxis K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003532 250.0
TLS2_k127_3189737_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 2.428e-273 853.0
TLS2_k127_3189737_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 586.0
TLS2_k127_3189737_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001076 242.0
TLS2_k127_3189737_3 preprotein translocase subunit YajC K03210 - - 0.00000000000000000000000000000000000000004453 155.0
TLS2_k127_3208041_1 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000000004842 242.0
TLS2_k127_3208041_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000134 163.0
TLS2_k127_3208041_3 PFAM PEGA domain protein - - - 0.00000000000000002112 93.0
TLS2_k127_3212127_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0 1215.0
TLS2_k127_3212127_1 argininosuccinate lyase K01755 - 4.3.2.1 1.116e-240 749.0
TLS2_k127_3212127_10 Fructosamine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003228 282.0
TLS2_k127_3212127_11 LytTr DNA-binding domain K08083 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005009 279.0
TLS2_k127_3212127_12 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.0000000000000000000000000000000000004014 142.0
TLS2_k127_3212127_2 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 579.0
TLS2_k127_3212127_3 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009463 474.0
TLS2_k127_3212127_4 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007217 390.0
TLS2_k127_3212127_5 enzyme of heme biosynthesis K02498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004099 333.0
TLS2_k127_3212127_6 HemX, putative uroporphyrinogen-III C-methyltransferase K02496 - 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 314.0
TLS2_k127_3212127_7 alginate biosynthesis protein AlgZ FimS K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 306.0
TLS2_k127_3212127_8 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 288.0
TLS2_k127_3212127_9 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001065 283.0
TLS2_k127_3217984_0 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 535.0
TLS2_k127_3217984_1 Protein of unknown function (DUF2863) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 465.0
TLS2_k127_3217984_2 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002215 288.0
TLS2_k127_3217984_3 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000007033 235.0
TLS2_k127_3226597_0 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 540.0
TLS2_k127_3226597_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008032 264.0
TLS2_k127_3226597_2 ATP ADP translocase K03301 - - 0.000000000000000000000000000000000000000000000000001486 192.0
TLS2_k127_3226597_3 - - - - 0.000000000000000000000000000000000000000000000009338 175.0
TLS2_k127_3226597_4 - - - - 0.0000000000001665 77.0
TLS2_k127_326627_0 Domain of unknown function (DUF4131) K02238 - - 3.19e-258 818.0
TLS2_k127_326627_1 Part of a membrane complex involved in electron transport K03615 - - 3.848e-200 643.0
TLS2_k127_326627_10 Part of a membrane complex involved in electron transport K03617 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 316.0
TLS2_k127_326627_11 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009576 313.0
TLS2_k127_326627_12 Part of a membrane complex involved in electron transport K03613 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 299.0
TLS2_k127_326627_13 protein conserved in bacteria K09928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006489 252.0
TLS2_k127_326627_14 Part of a membrane complex involved in electron transport K03612 - - 0.00000000000000000000000000000000000000000000000000000000000009007 233.0
TLS2_k127_326627_15 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000001813 203.0
TLS2_k127_326627_16 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000008576 119.0
TLS2_k127_326627_17 - - - - 0.0000000000000003303 78.0
TLS2_k127_326627_2 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 586.0
TLS2_k127_326627_3 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 495.0
TLS2_k127_326627_4 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 466.0
TLS2_k127_326627_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 431.0
TLS2_k127_326627_6 Part of a membrane complex involved in electron transport K03614 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 407.0
TLS2_k127_326627_7 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008062 396.0
TLS2_k127_326627_8 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 383.0
TLS2_k127_326627_9 Part of a membrane complex involved in electron transport K03616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006716 328.0
TLS2_k127_327757_0 aminopeptidase K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008106 575.0
TLS2_k127_327757_1 UbiH UbiF VisC COQ6 family K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001777 257.0
TLS2_k127_327784_0 AcrB/AcrD/AcrF family - - - 0.0 1146.0
TLS2_k127_3278828_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 5.047e-266 825.0
TLS2_k127_3278828_1 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005783 602.0
TLS2_k127_3278828_2 Diguanylate cyclase K13069,K21021 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000000007557 250.0
TLS2_k127_3278828_3 colicin V production K03558 - - 0.000000000000000000000000000000000000000000001699 170.0
TLS2_k127_3278828_4 - - - - 0.00000000000000000000000006793 114.0
TLS2_k127_3278828_5 Sporulation related domain K03749 - - 0.0000000000000000003046 90.0
TLS2_k127_32913_0 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 520.0
TLS2_k127_32913_1 Histidine kinase K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 391.0
TLS2_k127_32913_2 response regulator K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 344.0
TLS2_k127_3291849_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 0.0 1114.0
TLS2_k127_3291849_1 Belongs to the malic enzymes family K00029 - 1.1.1.40 0.0 1031.0
TLS2_k127_3291849_10 Cysteine-rich domain K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006666 340.0
TLS2_k127_3291849_11 Belongs to the peptidase S11 family K07262 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009428 323.0
TLS2_k127_3291849_12 Aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008044 280.0
TLS2_k127_3291849_13 LUD domain K00782 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005837 263.0
TLS2_k127_3291849_14 Mechanosensitive ion channel K22044 - - 0.000000000000000000000000000000000000000000000000000000000000000006511 235.0
TLS2_k127_3291849_2 Domain of unknown function (DUF3390) K18929 - - 1.73e-220 698.0
TLS2_k127_3291849_3 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000449 565.0
TLS2_k127_3291849_4 Sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 491.0
TLS2_k127_3291849_5 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00018,K00058 - 1.1.1.29,1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009382 412.0
TLS2_k127_3291849_6 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 414.0
TLS2_k127_3291849_7 Diguanylate cyclase, GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 386.0
TLS2_k127_3291849_8 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 365.0
TLS2_k127_3291849_9 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008344 343.0
TLS2_k127_330840_0 Molybdenum cofactor synthesis K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007381 411.0
TLS2_k127_330840_1 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.000000000000000000000000000000000000000000000000000000000004655 217.0
TLS2_k127_330840_2 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000006363 153.0
TLS2_k127_3349266_0 His Kinase A (phosphoacceptor) domain K07645 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 441.0
TLS2_k127_3349266_1 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000009033 137.0
TLS2_k127_3349266_2 Transcriptional regulatory protein, C terminal K07666 - - 0.0000000000000000000000000173 108.0
TLS2_k127_3377786_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004885 567.0
TLS2_k127_3377786_1 Domain of unknown function (DUF4143) K07133 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003667 472.0
TLS2_k127_3377786_2 methionine synthase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004785 275.0
TLS2_k127_3377786_3 Alpha beta hydrolase K00433 - 1.11.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000002811 248.0
TLS2_k127_3383624_0 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 336.0
TLS2_k127_3383624_1 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000000000000000000000000000000000000004432 228.0
TLS2_k127_3383624_2 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000000000000000000004559 136.0
TLS2_k127_3383624_3 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000002115 112.0
TLS2_k127_3384185_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1257.0
TLS2_k127_3384185_1 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003725 568.0
TLS2_k127_3384185_10 Protein of unknown function (DUF721) - - - 0.00000000000000001046 89.0
TLS2_k127_3384185_11 - - - - 0.00000006065 59.0
TLS2_k127_3384185_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 493.0
TLS2_k127_3384185_3 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 469.0
TLS2_k127_3384185_4 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 418.0
TLS2_k127_3384185_5 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 389.0
TLS2_k127_3384185_6 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 307.0
TLS2_k127_3384185_7 Class II aldolase adducin family protein K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 293.0
TLS2_k127_3384185_8 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000002594 233.0
TLS2_k127_3384185_9 KTSC domain - - - 0.00000000000000000000000000000001377 128.0
TLS2_k127_3405832_0 Phosphoglycerate kinase K00927 - 2.7.2.3 1.069e-217 683.0
TLS2_k127_3405832_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 3.004e-194 608.0
TLS2_k127_3405832_2 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 367.0
TLS2_k127_3405832_3 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000002122 242.0
TLS2_k127_3421575_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1219.0
TLS2_k127_3421575_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617 2.6.1.52 0.000000000000000000000000000000000000000000000000000004731 192.0
TLS2_k127_3421575_2 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000001625 160.0
TLS2_k127_3451000_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 378.0
TLS2_k127_3451000_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009315 256.0
TLS2_k127_3451000_2 cytochrome - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005881 258.0
TLS2_k127_3486142_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 4.649e-225 709.0
TLS2_k127_3486142_1 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000002177 68.0
TLS2_k127_3499411_0 Putative diguanylate phosphodiesterase - - - 8.357e-289 909.0
TLS2_k127_3499411_1 Major Facilitator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 531.0
TLS2_k127_3499411_2 Chromate transporter K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 518.0
TLS2_k127_3499411_3 2Fe-2S iron-sulfur cluster binding domain K00523 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006775 490.0
TLS2_k127_3499411_4 FIST_C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006154 369.0
TLS2_k127_3499411_5 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000005637 198.0
TLS2_k127_3499411_6 Peptidase S24-like - - - 0.0000000000000000000000000000004183 130.0
TLS2_k127_3502207_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005373 595.0
TLS2_k127_3502207_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000002884 230.0
TLS2_k127_3502207_2 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000006021 184.0
TLS2_k127_3502207_3 cobalamin (vitamin B12) biosynthesis CbiX protein K03795 - 4.99.1.3 0.0000000000000000000002922 112.0
TLS2_k127_350280_0 non-ribosomal peptide synthetase - - - 0.0 1148.0
TLS2_k127_350280_1 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 606.0
TLS2_k127_350280_2 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000003794 229.0
TLS2_k127_350280_3 alpha beta - - - 0.000000000000000000000000000000009382 138.0
TLS2_k127_350280_4 4'-phosphopantetheinyl transferase superfamily K06133 - - 0.0000000000000000000000000000000298 135.0
TLS2_k127_350280_5 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000006349 136.0
TLS2_k127_3518055_0 Domain of unknown function (DUF3391) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 298.0
TLS2_k127_3518055_1 Diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001768 297.0
TLS2_k127_3518055_2 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009526 273.0
TLS2_k127_3533588_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 3.21e-231 725.0
TLS2_k127_3556284_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 462.0
TLS2_k127_3556284_1 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000419 346.0
TLS2_k127_3602910_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 2.774e-259 812.0
TLS2_k127_3602910_1 HEAT repeats - - - 0.000000000000000000000000000000000000002577 150.0
TLS2_k127_3644581_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 612.0
TLS2_k127_3644581_1 COG0477 Permeases of the major facilitator superfamily K05820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002321 278.0
TLS2_k127_3644581_2 Protein of unknown function (DUF465) K09794 - - 0.000000000000000000000000000000153 125.0
TLS2_k127_3662906_0 Respiratory-chain NADH dehydrogenase K18005 - 1.12.1.2 1.066e-232 731.0
TLS2_k127_3662906_1 NiFe/NiFeSe hydrogenase small subunit C-terminal K06282 - 1.12.99.6 1.597e-196 618.0
TLS2_k127_3662906_2 4Fe-4S binding domain - - - 0.0000000002706 72.0
TLS2_k127_369493_0 Transcriptional regulatory protein, C terminal K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 371.0
TLS2_k127_369493_1 Histidine kinase K07637 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000006917 264.0
TLS2_k127_369493_2 Propeptide PepSY amd peptidase M4 - - - 0.00000000001564 65.0
TLS2_k127_3734452_0 Transcriptional regulatory protein, C terminal K07666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 309.0
TLS2_k127_3734452_1 Cobalamin adenosyltransferase K00798 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000001249 249.0
TLS2_k127_3734452_2 metal ion transport K14445 - - 0.0000000000000000000002354 96.0
TLS2_k127_3734452_3 Domain of unknown function (DUF1924) - - - 0.000000007253 61.0
TLS2_k127_3742499_0 PFAM LysE type translocator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 305.0
TLS2_k127_3742499_1 Protein of unknown function (DUF2867) - - - 0.00000000000000000000000000000000000000000000000000328 196.0
TLS2_k127_3742499_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000001327 118.0
TLS2_k127_3742499_3 - - - - 0.00000000000000000000000002016 113.0
TLS2_k127_3742499_4 - - - - 0.000000000000004112 77.0
TLS2_k127_3756850_0 Diguanylate cyclase - - - 2.239e-230 729.0
TLS2_k127_3756850_1 TIGRFAM outer membrane adhesin like proteiin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 542.0
TLS2_k127_3756850_2 COG1538 Outer membrane protein K12543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 496.0
TLS2_k127_3756850_3 Bacterial transglutaminase-like cysteine proteinase BTLCP - - - 0.0000000000000000000000000000000000000000000000000000000000000000005487 235.0
TLS2_k127_3774516_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0 1112.0
TLS2_k127_3774516_1 COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 6.031e-253 791.0
TLS2_k127_3774516_2 type II secretion system protein K02653 - - 6.966e-195 614.0
TLS2_k127_3774516_3 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006258 406.0
TLS2_k127_3774516_4 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001766 269.0
TLS2_k127_3774516_5 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000003407 230.0
TLS2_k127_3774516_6 Guanyl-specific ribonuclease Sa - - - 0.000000000000000000000000000000000007698 141.0
TLS2_k127_3774516_7 Putative regulatory protein - - - 0.0000000000000000000000000000000002701 135.0
TLS2_k127_3774516_8 Barstar (barnase inhibitor) - - - 0.000000000000000000000000000000005864 133.0
TLS2_k127_3774516_9 NUDIX domain K08310 - 3.6.1.67 0.0000000005157 63.0
TLS2_k127_3774854_0 Flavocytochrome c sulphide dehydrogenase, flavin-binding K17218,K17229 - 1.8.2.3,1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 561.0
TLS2_k127_3774854_1 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000002348 263.0
TLS2_k127_3774854_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000001034 188.0
TLS2_k127_3774854_3 Pfam cytochrome c K17230 - - 0.000000000000000000000000000000000000000000000006685 179.0
TLS2_k127_3774854_4 Ethylbenzene dehydrogenase - - - 0.00000000000000000000000000000000000005573 146.0
TLS2_k127_3775110_0 Concanavalin A-like lectin/glucanases superfamily K12287 - - 6.631e-250 812.0
TLS2_k127_3775110_1 Type II secretion system (T2SS), protein F K02455,K12278 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 511.0
TLS2_k127_3775110_2 Prokaryotic N-terminal methylation motif K12285 - - 0.00000000000000000000000000000000000000000000000000000000000000005869 231.0
TLS2_k127_3775110_3 Prokaryotic N-terminal methylation motif K10924 - - 0.00000000000000000000000000000003631 131.0
TLS2_k127_3775110_4 type IV pilus modification protein PilV K10927 - - 0.00000000000000000000000000000009188 129.0
TLS2_k127_3775110_5 Tfp pilus assembly protein FimT K10926 - - 0.0000000000000000000000001596 119.0
TLS2_k127_3775110_6 Prokaryotic N-terminal methylation motif K10924 - - 0.000002779 59.0
TLS2_k127_3778216_0 chemotaxis K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 389.0
TLS2_k127_3778216_1 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000002812 169.0
TLS2_k127_3778216_2 Protein of unknown function (DUF1015) - - - 0.00000000000002799 72.0
TLS2_k127_3782445_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 537.0
TLS2_k127_3782445_1 TonB C terminal - - - 0.0001843 52.0
TLS2_k127_3783468_0 Peptidase M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004037 508.0
TLS2_k127_3783468_1 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000000000000000005725 241.0
TLS2_k127_3783468_2 sulfur oxidation protein SoxY K17226 - - 0.000000000000000000000000000000000000000000000003157 177.0
TLS2_k127_3783468_3 Sulphur oxidation protein SoxZ K17227 - - 0.000000000000000000000000000000001644 132.0
TLS2_k127_3783468_4 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.0000000000000000000000000006116 115.0
TLS2_k127_3788613_0 Cytochrome c bacterial - - - 2.297e-211 670.0
TLS2_k127_3788613_1 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006067 585.0
TLS2_k127_3788613_2 LysR substrate binding domain K04761 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005575 389.0
TLS2_k127_3788613_3 Prokaryotic cytochrome b561 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005624 326.0
TLS2_k127_3788613_4 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003885 289.0
TLS2_k127_3788613_5 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000004489 242.0
TLS2_k127_3788613_6 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000000000000000008688 209.0
TLS2_k127_3788613_7 PFAM Dinitrogenase iron-molybdenum cofactor - - - 0.000000000000000000000000000000000006937 140.0
TLS2_k127_3788613_8 - - - - 0.00000000000001724 74.0
TLS2_k127_3790231_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 411.0
TLS2_k127_3790231_1 anthranilate K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 299.0
TLS2_k127_3790995_0 Cytochrome c554 and c-prime - - - 3.415e-226 711.0
TLS2_k127_3790995_1 Ethylbenzene dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 285.0
TLS2_k127_3790995_2 Pfam cytochrome c K08738 - - 0.00000000000000000000008403 104.0
TLS2_k127_3791928_0 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 655.0
TLS2_k127_3791928_1 Part of a membrane complex involved in electron transport K03614 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 387.0
TLS2_k127_3791928_2 Part of a membrane complex involved in electron transport K03613 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003473 306.0
TLS2_k127_3791928_3 PpiC-type peptidyl-prolyl cis-trans isomerase K01802,K03769 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007469 278.0
TLS2_k127_3791928_4 Part of a membrane complex involved in electron transport K03612 - - 0.000000000000000000000000000000000000000000000000000000000000000002207 244.0
TLS2_k127_3791928_5 NifZ domain K02597 - - 0.0000000000000000000000000000000000000000000000000000000000529 213.0
TLS2_k127_3791928_6 Belongs to the UPF0125 (RnfH) family K09801 - - 0.000000000000000000000000000000000000001156 149.0
TLS2_k127_3791928_7 May protect the nitrogenase Fe-Mo protein from oxidative damage K02595 - - 0.000000000000000000000003927 108.0
TLS2_k127_3791928_8 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000001281 85.0
TLS2_k127_3791928_9 Belongs to the alpha-IPM synthase homocitrate synthase family K02594 - 2.3.3.14 0.0000000001279 63.0
TLS2_k127_3799193_0 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 - 3.6.4.13 1.133e-209 666.0
TLS2_k127_3799193_1 Collagenase K08303 - - 0.00000000000002869 74.0
TLS2_k127_3821620_0 HWE histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 474.0
TLS2_k127_3821620_1 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000002309 213.0
TLS2_k127_3821620_2 YCII-related domain - - - 0.00000000000000000000000000000000000000000199 159.0
TLS2_k127_3821620_3 HWE histidine kinase - - - 0.00000000000000000000000000000004752 130.0
TLS2_k127_3821620_4 ABC transporter transmembrane region 2 K02471 - - 0.00000000000002105 76.0
TLS2_k127_3821620_5 HWE histidine kinase - - - 0.000000002674 60.0
TLS2_k127_382275_0 TrkA-C domain K03455 - - 5.374e-215 686.0
TLS2_k127_382275_1 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 514.0
TLS2_k127_382275_10 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.00000000000000000000000534 113.0
TLS2_k127_382275_11 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000002037 86.0
TLS2_k127_382275_12 Histidine kinase-like ATPases - - - 0.00000000000003521 77.0
TLS2_k127_382275_2 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 432.0
TLS2_k127_382275_3 Domain of unknown function (DUF4872) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 316.0
TLS2_k127_382275_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 326.0
TLS2_k127_382275_5 HipA domain protein K07154 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003256 292.0
TLS2_k127_382275_6 Prokaryotic N-terminal methylation motif - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009409 260.0
TLS2_k127_382275_7 Phasin protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001371 241.0
TLS2_k127_382275_8 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.000000000000000000000000000000000000000000000000000000007627 203.0
TLS2_k127_382275_9 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.0000000000000000000000000000000000000000000000000000161 196.0
TLS2_k127_3828600_0 Catalyzes the addition of the first glucose residue to the LPS core K02844 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 331.0
TLS2_k127_3828600_1 epimerase dehydratase K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000001027 202.0
TLS2_k127_3828600_2 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.000000000000000000000000000000000000000000000000000000003246 210.0
TLS2_k127_3852459_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00436 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 588.0
TLS2_k127_3852459_1 4Fe-4S single cluster domain K18006 - 1.12.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004945 382.0
TLS2_k127_3852459_2 NADH ubiquinone oxidoreductase, 20 K18007 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 325.0
TLS2_k127_3852459_3 Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K18005 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000001648 216.0
TLS2_k127_3852459_4 Isocitrate/isopropylmalate dehydrogenase K00031 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 0.00000000000000000000000000000000000000000002741 164.0
TLS2_k127_3853681_0 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 419.0
TLS2_k127_3853681_1 Protein of unknown function, DUF484 K09921 - - 0.00000000000000000000000000000000000000000000000000000000000002087 224.0
TLS2_k127_3853681_2 SMART CoA-binding domain protein K06929 - - 0.0000000000000000000000000000000000000000000000000001034 188.0
TLS2_k127_3853681_3 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000003436 141.0
TLS2_k127_3869427_0 ABC transporter transmembrane region K06147 - - 1.563e-246 771.0
TLS2_k127_3869427_1 cyanophycin synthetase K03802 - 6.3.2.29,6.3.2.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 612.0
TLS2_k127_3870159_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 3.852e-253 785.0
TLS2_k127_3870159_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 582.0
TLS2_k127_3870159_2 Domain of unknown function (DUF4139) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 452.0
TLS2_k127_3870159_3 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 414.0
TLS2_k127_3870159_4 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 378.0
TLS2_k127_3870159_5 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004288 362.0
TLS2_k127_3870159_6 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000000000000001084 231.0
TLS2_k127_3870159_7 PFAM Sporulation domain protein - - - 0.00000000000000000000003872 106.0
TLS2_k127_3870159_8 - - - - 0.000000002116 66.0
TLS2_k127_3870159_9 - - - - 0.0002405 44.0
TLS2_k127_3874772_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 6.608e-211 666.0
TLS2_k127_3874772_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007104 460.0
TLS2_k127_3874772_10 - - - - 0.000000000000000000000000000000000000000004846 160.0
TLS2_k127_3874772_11 Bacterial SH3 domain - - - 0.0000000000000000000000000000000000000000429 157.0
TLS2_k127_3874772_12 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000005864 154.0
TLS2_k127_3874772_13 Protein of unknown function (DUF2721) - - - 0.00000000000000000000000000000000000001204 151.0
TLS2_k127_3874772_14 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.00000000000000000000000000000002018 137.0
TLS2_k127_3874772_2 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 404.0
TLS2_k127_3874772_3 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007637 393.0
TLS2_k127_3874772_4 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 395.0
TLS2_k127_3874772_5 peptidase, M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 323.0
TLS2_k127_3874772_6 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000000000000002732 237.0
TLS2_k127_3874772_7 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.000000000000000000000000000000000000000000000000000000000000000002595 229.0
TLS2_k127_3874772_8 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.0000000000000000000000000000000000000000000000000000000000005721 214.0
TLS2_k127_3874772_9 transcriptional - - - 0.0000000000000000000000000000000000000000000000001413 180.0
TLS2_k127_3886696_0 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases - - - 6.482e-255 794.0
TLS2_k127_3888165_0 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 464.0
TLS2_k127_3888165_1 Cytochrome C oxidase, cbb3-type, subunit III K19713 - 1.8.2.2 0.000000000000000000000000000000000000000000000000000000000000000000002113 246.0
TLS2_k127_3888165_2 sulphate transporter K03321 - - 0.00000000000000000000000000000000000001829 162.0
TLS2_k127_3888165_3 response regulator receiver K13041 - - 0.0000000000000000000000000000001067 128.0
TLS2_k127_3899620_0 extracellular solute-binding protein - - - 0.0 1053.0
TLS2_k127_3899620_1 peptidylprolyl isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 573.0
TLS2_k127_3899620_2 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 446.0
TLS2_k127_3899620_3 C-terminal, D2-small domain, of ClpB protein K03544 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006636 455.0
TLS2_k127_3899620_4 Belongs to the pseudouridine synthase RsuA family K06182 - 5.4.99.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 371.0
TLS2_k127_3899620_5 PFAM L-carnitine dehydratase bile acid-inducible protein F K01067,K01796 - 3.1.2.1,5.1.99.4 0.00000000000000000000000000000000000000000000000000000000000000002485 240.0
TLS2_k127_3899620_6 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.0000000000000000000000000000000000000000000005128 170.0
TLS2_k127_390901_0 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 557.0
TLS2_k127_390901_1 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 438.0
TLS2_k127_390901_10 Phosphate starvation-inducible protein psiF - - - 0.000000111 59.0
TLS2_k127_390901_2 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 440.0
TLS2_k127_390901_3 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004936 402.0
TLS2_k127_390901_4 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 K22132 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 309.0
TLS2_k127_390901_5 Forkhead associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 299.0
TLS2_k127_390901_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002432 278.0
TLS2_k127_390901_7 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007189 250.0
TLS2_k127_390901_8 COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) K02806 - - 0.0000000000000000000000000000000000000000000000000000000000000000005626 231.0
TLS2_k127_390901_9 sigma 54 modulation protein K05808 - - 0.000000000000000000000000000000000000000007459 155.0
TLS2_k127_3922415_0 Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 309.0
TLS2_k127_3922415_1 gag-polyprotein putative aspartyl protease K06985 - - 0.000000000000000000000000000000000000000000000000000000000000539 217.0
TLS2_k127_3922415_2 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.0000000000000000000000000000000000000000000000000000000004424 209.0
TLS2_k127_3922415_3 Protein of unknown function (DUF1255) K09913 - 2.4.2.1,2.4.2.2 0.000000000000000000000000000000000000000000001468 165.0
TLS2_k127_3922415_4 Belongs to the UPF0234 family K09767 - - 0.000000000000000000000000000000002914 134.0
TLS2_k127_3923522_0 twitching motility protein K02670 - - 3.387e-206 645.0
TLS2_k127_3923522_1 twitching motility protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 550.0
TLS2_k127_3923522_2 Belongs to the methyltransferase superfamily K07444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 329.0
TLS2_k127_3923690_0 Cytochrome c K02198 - - 4.295e-303 944.0
TLS2_k127_3923690_1 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000009215 107.0
TLS2_k127_392776_0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007663 563.0
TLS2_k127_392776_1 KR domain K00023,K00059 - 1.1.1.100,1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 287.0
TLS2_k127_3935420_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 6.409e-286 884.0
TLS2_k127_3935420_1 Beta-lactamase - - - 2.576e-247 775.0
TLS2_k127_3935420_2 Cysteine-rich domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004683 573.0
TLS2_k127_3935420_3 Transcriptional regulator K04761 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 385.0
TLS2_k127_3935420_4 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006411 271.0
TLS2_k127_3935420_5 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000111 259.0
TLS2_k127_3935420_6 HHE cation binding domain K07216 - - 0.0000000000000000000000000000000000006447 145.0
TLS2_k127_3935420_7 AAA ATPase domain - - - 0.000001602 58.0
TLS2_k127_3935420_8 CBS-domain-containing membrane protein K07168 - - 0.000006736 51.0
TLS2_k127_394007_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 536.0
TLS2_k127_394007_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 347.0
TLS2_k127_394007_2 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0000000000224 63.0
TLS2_k127_3940451_0 TonB dependent receptor K02014 - - 0.0 1045.0
TLS2_k127_3940451_1 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 1.207e-221 695.0
TLS2_k127_3940451_2 deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 575.0
TLS2_k127_3940451_3 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 547.0
TLS2_k127_3940451_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 311.0
TLS2_k127_3940451_5 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007752 293.0
TLS2_k127_3940451_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 294.0
TLS2_k127_3940451_7 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0000000000000000000000001502 114.0
TLS2_k127_3940516_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004656 599.0
TLS2_k127_3940516_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 527.0
TLS2_k127_3940516_2 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 301.0
TLS2_k127_3940516_3 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000055 233.0
TLS2_k127_394287_0 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004525 589.0
TLS2_k127_394287_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003973 306.0
TLS2_k127_394287_2 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002741 273.0
TLS2_k127_3947921_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000378 429.0
TLS2_k127_3947921_1 PFAM Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 383.0
TLS2_k127_3948389_0 AAA domain K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 511.0
TLS2_k127_3948389_1 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007247 308.0
TLS2_k127_3948389_2 Iron-sulphur cluster biosynthesis K13628 - - 0.0000000000000000003211 102.0
TLS2_k127_3951708_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 4.728e-236 735.0
TLS2_k127_3951708_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 558.0
TLS2_k127_3951708_2 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 548.0
TLS2_k127_3951708_3 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 536.0
TLS2_k127_3951708_4 Belongs to the cysteine synthase cystathionine beta- synthase family K12339 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 494.0
TLS2_k127_3951708_5 pfkB family carbohydrate kinase K21344 - 2.7.1.167 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 436.0
TLS2_k127_3951708_6 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 340.0
TLS2_k127_3951708_7 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.000000000000000000000000000000000000000000000007447 173.0
TLS2_k127_3951708_9 Pfam:DUF1049 K08992 - - 0.0000000000000003822 81.0
TLS2_k127_3963301_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1321.0
TLS2_k127_3963301_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 617.0
TLS2_k127_3963301_10 Phosphopantetheine attachment site K02078 - - 0.000000000000000000000000000006072 121.0
TLS2_k127_3963301_11 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000000001094 119.0
TLS2_k127_3963301_12 AMP-binding enzyme - - - 0.0000000000000001309 94.0
TLS2_k127_3963301_13 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000002035 79.0
TLS2_k127_3963301_14 Phosphopantetheine attachment site K02078 - - 0.00000000000001334 76.0
TLS2_k127_3963301_15 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000002333 64.0
TLS2_k127_3963301_2 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 540.0
TLS2_k127_3963301_3 exporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005614 538.0
TLS2_k127_3963301_4 AMP-binding enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 498.0
TLS2_k127_3963301_5 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003913 488.0
TLS2_k127_3963301_6 Acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 423.0
TLS2_k127_3963301_7 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 321.0
TLS2_k127_3963301_8 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000000000002206 208.0
TLS2_k127_3963301_9 membrane - - - 0.00000000000000000000000000000000000000000223 163.0
TLS2_k127_3977263_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 7.109e-207 649.0
TLS2_k127_3977263_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000325 569.0
TLS2_k127_3977263_10 Required for insertion of 4Fe-4S clusters K15724 - - 0.000000000000000000000000000000000000000000000000000000000202 204.0
TLS2_k127_3977263_11 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000000000000000002295 168.0
TLS2_k127_3977263_2 Long-chain fatty acid transport protein K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005091 443.0
TLS2_k127_3977263_3 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009831 308.0
TLS2_k127_3977263_4 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 292.0
TLS2_k127_3977263_5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008172 269.0
TLS2_k127_3977263_6 Gram-negative porin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002685 252.0
TLS2_k127_3977263_7 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000000000000000001269 226.0
TLS2_k127_3977263_8 redox protein, regulator of disulfide bond formation K07397 - - 0.00000000000000000000000000000000000000000000000000000000000000001425 226.0
TLS2_k127_3977263_9 - - - - 0.0000000000000000000000000000000000000000000000000000000001452 214.0
TLS2_k127_3987734_0 Histidine kinase K07638 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 432.0
TLS2_k127_3987734_1 Glycosyl transferase family 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008068 374.0
TLS2_k127_3987734_2 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07659 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 356.0
TLS2_k127_3987734_3 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 339.0
TLS2_k127_3987734_4 uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 323.0
TLS2_k127_3987734_5 chemotaxis K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004567 250.0
TLS2_k127_3987734_6 Peptidase M22 glycoprotease K14742 - - 0.00000000000000000000000000000000000000000000000000000000719 205.0
TLS2_k127_3987734_7 Bacterial-like globin K06886 - - 0.0000000000000000000000000000000000000000000000000008649 186.0
TLS2_k127_3987734_8 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.000000000000000000000000000000000000001126 155.0
TLS2_k127_3990063_0 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 419.0
TLS2_k127_3990063_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 285.0
TLS2_k127_3993984_0 Male sterility protein K02473 - 5.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 566.0
TLS2_k127_3993984_1 UDP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 431.0
TLS2_k127_3993984_2 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 396.0
TLS2_k127_4006090_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 358.0
TLS2_k127_4006090_1 Uncharacterized protein family UPF0016 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 312.0
TLS2_k127_4006090_2 Protein of unknown function (DUF3301) - - - 0.00000000000000000000000005832 110.0
TLS2_k127_4006090_3 - - - - 0.0000000000000005846 79.0
TLS2_k127_4006090_4 - - - - 0.00002093 53.0
TLS2_k127_4033438_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007305 393.0
TLS2_k127_4033438_1 Phosphoglycolate phosphatase K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 329.0
TLS2_k127_4033438_2 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000004468 143.0
TLS2_k127_4038490_0 COG0643 Chemotaxis protein histidine kinase and related kinases K02487,K06596 - - 9.706e-284 891.0
TLS2_k127_4038490_1 COG0044 Dihydroorotase and related cyclic amidohydrolases K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008923 573.0
TLS2_k127_4038490_2 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 533.0
TLS2_k127_4038490_3 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001092 273.0
TLS2_k127_4038490_4 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001664 276.0
TLS2_k127_4038490_5 Phosphoribosyl transferase domain K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000002824 187.0
TLS2_k127_4038490_6 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000000000000000000000133 172.0
TLS2_k127_4054254_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.0 1053.0
TLS2_k127_4054254_1 Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002962 272.0
TLS2_k127_4054744_0 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 1.233e-203 641.0
TLS2_k127_4054744_1 TRAP transporter solute receptor, TAXI family K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 443.0
TLS2_k127_4054744_2 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 293.0
TLS2_k127_4055390_0 Belongs to the heme-copper respiratory oxidase family K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 464.0
TLS2_k127_4055390_1 Cytochrome C and Quinol oxidase polypeptide I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 289.0
TLS2_k127_4055390_2 SCO1/SenC K07152 - - 0.00000000000000000000000000000000005768 143.0
TLS2_k127_407747_0 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006064 432.0
TLS2_k127_407747_1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 365.0
TLS2_k127_407747_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 357.0
TLS2_k127_407747_3 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004133 279.0
TLS2_k127_407747_4 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006063 239.0
TLS2_k127_407747_5 HD domain - - - 0.00000000000000000000000000000000000000000000000001258 187.0
TLS2_k127_4089531_0 PFAM Acetyl-CoA hydrolase transferase K01067 - 3.1.2.1 1.22e-235 734.0
TLS2_k127_4089531_1 HI0933-like protein K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 561.0
TLS2_k127_4089531_2 Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity K14540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003288 447.0
TLS2_k127_4089531_3 Belongs to the glucose-6-phosphate 1-epimerase family K01792 - 5.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009739 345.0
TLS2_k127_4089531_4 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.000000000000001089 78.0
TLS2_k127_4095226_0 of ABC transporters with duplicated ATPase - - - 2.011e-227 708.0
TLS2_k127_4095226_1 Transporter associated domain K03699 - - 4.849e-207 652.0
TLS2_k127_4095226_2 GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 535.0
TLS2_k127_4095226_3 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006349 408.0
TLS2_k127_4095226_4 Fic/DOC family - - - 0.0000000000000000000000000000000000000000000000000001429 198.0
TLS2_k127_4095226_5 Belongs to the pirin family K06911 - - 0.000000000000007021 83.0
TLS2_k127_409619_0 Cytochrome c554 and c-prime - - - 1.476e-279 874.0
TLS2_k127_409619_1 TonB dependent receptor K02014 - - 1.507e-226 710.0
TLS2_k127_409619_2 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 6.133e-219 722.0
TLS2_k127_409619_3 Flavocytochrome c sulphide dehydrogenase, flavin-binding K17229 - 1.8.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005005 280.0
TLS2_k127_409619_5 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000001197 119.0
TLS2_k127_4119310_0 LeuA allosteric (dimerisation) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 415.0
TLS2_k127_4119310_1 COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase K02548 - 2.5.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 361.0
TLS2_k127_4119310_2 May be involved in recombination K03554 - - 0.00000000000000000000000000000000000000000000000000000000001467 209.0
TLS2_k127_4119310_3 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000001256 147.0
TLS2_k127_4119310_4 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000000000000005011 141.0
TLS2_k127_4144943_0 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.0000000000000000000000000000000000000000000000000000000003871 218.0
TLS2_k127_4144943_1 - - - - 0.000000000000000000000000000000000000000000000000000001426 201.0
TLS2_k127_4173896_0 Transglutaminase/protease-like homologues K22452 - 2.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008036 608.0
TLS2_k127_4173896_1 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 375.0
TLS2_k127_4173896_2 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 290.0
TLS2_k127_4173896_3 lytic murein transglycosylase K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002364 256.0
TLS2_k127_4183993_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - 5.592e-225 704.0
TLS2_k127_4183993_1 Prokaryotic N-terminal methylation motif - - - 0.0000000000000000000000000000004298 128.0
TLS2_k127_4183993_2 Prokaryotic N-terminal methylation motif K02650,K02655 - - 0.000000000000000004259 89.0
TLS2_k127_4187086_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 4.971e-204 643.0
TLS2_k127_4187086_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005724 477.0
TLS2_k127_4187086_2 Belongs to the glycosyl hydrolase 57 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004492 433.0
TLS2_k127_4217014_0 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 2.921e-208 653.0
TLS2_k127_4217014_1 Acetyl-coenzyme A synthetase N-terminus K01907 - 6.2.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 344.0
TLS2_k127_4217014_2 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K13819 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002028 242.0
TLS2_k127_4250594_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 496.0
TLS2_k127_4250594_1 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000000000000000001606 187.0
TLS2_k127_4250594_2 FKBP-type peptidyl-prolyl cis-trans isomerase - - - 0.00000000000000000000000000000004243 128.0
TLS2_k127_4262280_0 Bacterial transcriptional repressor - - - 0.0000000000000000000000000000000000000000000000000000002009 206.0
TLS2_k127_4262280_1 Aldo keto - - - 0.000000000000000000000000000000000000000000000000000001039 198.0
TLS2_k127_4262280_2 granule-associated protein - - - 0.00000006013 61.0
TLS2_k127_4262280_3 Prolyl oligopeptidase - - - 0.0000001934 62.0
TLS2_k127_4264266_0 Signal transduction histidine kinase K11711 - 2.7.13.3 4.261e-199 644.0
TLS2_k127_4264266_1 response regulator K11712 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005093 257.0
TLS2_k127_4264266_2 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K11688 - - 0.000000000000000000000001768 104.0
TLS2_k127_426755_0 Hydrolase of alkaline phosphatase superfamily K07014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 608.0
TLS2_k127_426755_1 Phosphoglucomutase K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 315.0
TLS2_k127_4270941_0 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000334 459.0
TLS2_k127_4270941_1 Proton-conducting membrane transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004149 353.0
TLS2_k127_4292493_0 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005723 563.0
TLS2_k127_4292493_1 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 286.0
TLS2_k127_4307726_0 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007146 567.0
TLS2_k127_4307726_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009113 564.0
TLS2_k127_4307726_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000001045 269.0
TLS2_k127_4307726_3 - - - - 0.0000000000000000000000003162 115.0
TLS2_k127_4352208_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 1.615e-274 852.0
TLS2_k127_4352208_1 Proton-conducting membrane transporter K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 319.0
TLS2_k127_4352208_2 Universal stress protein family - - - 0.00001668 54.0
TLS2_k127_438250_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 6.682e-239 744.0
TLS2_k127_438250_1 COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 313.0
TLS2_k127_438250_2 COG1905 NADH ubiquinone oxidoreductase 24 kD subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000002847 258.0
TLS2_k127_438250_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.00000000000000000000000000000000000003491 143.0
TLS2_k127_438337_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 3.5e-322 999.0
TLS2_k127_438337_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 569.0
TLS2_k127_438337_2 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 382.0
TLS2_k127_438337_3 COG1982 Arginine lysine ornithine decarboxylases K01584 - 4.1.1.19 0.000000000000000000000000008727 114.0
TLS2_k127_4408310_0 Nickel-dependent hydrogenase K06281 - 1.12.99.6 1.34e-263 814.0
TLS2_k127_4408310_1 Prokaryotic cytochrome b561 K03620 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005531 277.0
TLS2_k127_4445554_0 pyruvate phosphate dikinase K01006,K01007 - 2.7.9.1,2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 425.0
TLS2_k127_4445554_1 ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 329.0
TLS2_k127_4445554_2 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.000000000000000000000000000000000000000000000000000000000000000000002147 243.0
TLS2_k127_4445554_3 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000003154 216.0
TLS2_k127_4478438_0 Phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006591 531.0
TLS2_k127_4478438_1 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 544.0
TLS2_k127_4478438_2 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 485.0
TLS2_k127_4478438_3 Amidohydrolase K01686 - 4.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 365.0
TLS2_k127_4478438_4 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000005011 239.0
TLS2_k127_4478438_5 MlaD protein K06192 - - 0.00000000000000000000000000000000000000000000000000008217 197.0
TLS2_k127_4502107_0 Glycosyl hydrolase 36 superfamily, catalytic domain - - - 0.0 1847.0
TLS2_k127_4502107_1 Periplasmic or secreted lipoprotein - - - 0.000000000000000000000000000000000000000000002265 166.0
TLS2_k127_4519901_0 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 505.0
TLS2_k127_4519901_1 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009334 364.0
TLS2_k127_4519901_2 enzyme of heme biosynthesis K02498 - - 0.0008996 43.0
TLS2_k127_4590716_0 Acetyl-coenzyme A synthetase N-terminus K01907 - 6.2.1.16 1.119e-217 679.0
TLS2_k127_4590716_1 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 601.0
TLS2_k127_4590716_2 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000004961 261.0
TLS2_k127_4590716_3 Isochorismatase hydrolase - - - 0.0000000000000000000000000000000000000000000000000000002957 202.0
TLS2_k127_4590716_4 Thioesterase superfamily K07107 - - 0.0000000000000000000000000000000000000000000000000002106 190.0
TLS2_k127_4590716_5 - - - - 0.0000000001717 63.0
TLS2_k127_4598096_0 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 351.0
TLS2_k127_4598096_1 Parallel beta-helix repeats - - - 0.00000000000000000001005 103.0
TLS2_k127_4598096_2 - - - - 0.0000000000004222 76.0
TLS2_k127_4598504_0 Chemotaxis signal transduction protein K03415 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009223 494.0
TLS2_k127_4598504_1 Chemotaxis signal transduction protein K03415 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 481.0
TLS2_k127_4598504_10 Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) K03414 - - 0.000000000000000000000000000000000000000000000000000000000000008324 226.0
TLS2_k127_4598504_11 Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways K02403 - - 0.0000000000000000000000000000006084 124.0
TLS2_k127_4598504_12 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 0.000000001578 58.0
TLS2_k127_4598504_2 flagellar motor K02556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007651 475.0
TLS2_k127_4598504_3 PFAM OmpA MotB domain protein K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004276 407.0
TLS2_k127_4598504_4 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 394.0
TLS2_k127_4598504_5 Nudix N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001325 280.0
TLS2_k127_4598504_6 Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways K02402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001137 272.0
TLS2_k127_4598504_7 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000005264 243.0
TLS2_k127_4598504_8 Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions K02553 - - 0.00000000000000000000000000000000000000000000000000000000000000003342 229.0
TLS2_k127_4598504_9 response regulator K03413 - - 0.0000000000000000000000000000000000000000000000000000000000000001353 226.0
TLS2_k127_4601237_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 576.0
TLS2_k127_4601237_1 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 523.0
TLS2_k127_465050_0 Polyphosphate kinase 2 (PPK2) - - - 2.514e-259 805.0
TLS2_k127_465050_1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006203 601.0
TLS2_k127_465050_10 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000003886 232.0
TLS2_k127_465050_11 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000000000000000000000000000000000001259 160.0
TLS2_k127_465050_2 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 583.0
TLS2_k127_465050_3 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 426.0
TLS2_k127_465050_4 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 333.0
TLS2_k127_465050_5 Transcriptional regulator K21703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 323.0
TLS2_k127_465050_6 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 312.0
TLS2_k127_465050_7 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 306.0
TLS2_k127_465050_8 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001432 283.0
TLS2_k127_465050_9 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000000001346 269.0
TLS2_k127_465938_0 COGs COG1653 ABC-type sugar transport system periplasmic component K02027 - - 8.081e-224 703.0
TLS2_k127_465938_1 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000008321 167.0
TLS2_k127_465938_2 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000011 117.0
TLS2_k127_4660139_0 FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003967 542.0
TLS2_k127_4660139_1 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 413.0
TLS2_k127_4660139_2 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005496 376.0
TLS2_k127_4671937_1 - - - - 0.00000000000000000000000000000000000000000001525 165.0
TLS2_k127_4671937_2 PFAM von Willebrand factor type A K02448 - - 0.000000000000000000000000000000000000000001855 157.0
TLS2_k127_4675933_0 B12 binding domain K22491 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003103 427.0
TLS2_k127_4675933_1 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000001042 253.0
TLS2_k127_4675933_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000004877 228.0
TLS2_k127_4678668_0 Cytochrome C and Quinol oxidase polypeptide I K04561 - 1.7.2.5 0.0 1011.0
TLS2_k127_4678668_1 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009033 374.0
TLS2_k127_4678668_2 Tellurite resistance protein TerB - - - 0.00001147 49.0
TLS2_k127_4708412_0 modulator of DNA gyrase K03592 - - 8.107e-195 625.0
TLS2_k127_4708412_1 Methyltransferase type 11 K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 597.0
TLS2_k127_4708412_2 Protein of unknown function (DUF3641) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 484.0
TLS2_k127_4708412_3 Lysine methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004623 271.0
TLS2_k127_4708412_4 Molybdenum cofactor biosynthesis protein K03831 - 2.7.7.75 0.00000000000000000000000000000000000000000000000000000000000000004776 229.0
TLS2_k127_4708412_5 Belongs to the UPF0307 family K09889 - - 0.000000000000000000000000000000000000000000000000004132 187.0
TLS2_k127_4708412_6 Putative DNA-binding domain - - - 0.000000000000000000000000000000000000000000001007 169.0
TLS2_k127_4708412_7 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000000001572 149.0
TLS2_k127_4708412_8 Cold shock protein domain K03704 - - 0.00000000000000000000000000000001001 130.0
TLS2_k127_4708412_9 Transcriptional regulator - - - 0.000000000000000000000209 100.0
TLS2_k127_4716489_0 Diguanylate cyclase - - - 3.284e-207 662.0
TLS2_k127_4716489_1 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003524 550.0
TLS2_k127_4716489_2 Bacterial extracellular solute-binding protein K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006014 541.0
TLS2_k127_4716489_3 COG1613 ABC-type sulfate transport system, periplasmic component K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 437.0
TLS2_k127_4716489_4 PBP superfamily domain K02040 - - 0.00000000000000000000000000000000000000000000000000000000000004578 223.0
TLS2_k127_4716489_5 Transcriptional regulator, LysR family K13634,K13635 - - 0.000000000000000000000000000000000000007931 147.0
TLS2_k127_4716489_6 chemotaxis, protein K03406 - - 0.0003226 51.0
TLS2_k127_4721840_0 Belongs to the MurCDEF family K03802 - 6.3.2.29,6.3.2.30 0.0 1192.0
TLS2_k127_4721840_1 cyanophycin synthetase K03802 - 6.3.2.29,6.3.2.30 3.458e-270 847.0
TLS2_k127_4722591_0 SMART zinc finger, CDGSH-type domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009681 303.0
TLS2_k127_4722591_1 Dioxygenase K00449 - 1.13.11.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 299.0
TLS2_k127_4722591_2 -acetyltransferase K00657 - 2.3.1.57 0.00000000000000000000000000000000000000000000000000000000000000006824 228.0
TLS2_k127_4722591_3 YCII-related domain - - - 0.00000000000000000000000000000000000000000003484 168.0
TLS2_k127_4722591_4 Predicted integral membrane protein (DUF2189) - - - 0.00000000000000000000000000000006966 128.0
TLS2_k127_4722591_5 - - - - 0.0000000000002549 72.0
TLS2_k127_4741070_0 Putative diguanylate phosphodiesterase - - - 8.23e-213 683.0
TLS2_k127_4741070_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 518.0
TLS2_k127_4741070_2 Histidine kinase K20975 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 438.0
TLS2_k127_4741070_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002731 251.0
TLS2_k127_4741070_4 - - - - 0.0000000000000000000000000003794 118.0
TLS2_k127_4741070_5 Domain of unknown function (DUF4202) - - - 0.0000000000000003869 78.0
TLS2_k127_4752940_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 8.863e-283 874.0
TLS2_k127_4752940_1 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001115 264.0
TLS2_k127_4752940_2 PFAM regulatory protein LuxR - - - 0.000000000002327 77.0
TLS2_k127_4753462_0 Protein of unknown function (DUF3141) - - - 5.468e-302 941.0
TLS2_k127_4753462_1 Sugar (and other) transporter - - - 2.408e-264 821.0
TLS2_k127_4753462_10 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000001212 240.0
TLS2_k127_4753462_11 PFAM Metal-dependent phosphohydrolase, HD - - - 0.0000000000000000000000000000000000000000000000003157 188.0
TLS2_k127_4753462_12 Poly(3-hydroxybutyrate) depolymerase - - - 0.00000000000000000000000000000000000000606 145.0
TLS2_k127_4753462_13 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000473 139.0
TLS2_k127_4753462_14 ABC-type transport auxiliary lipoprotein component K09857 - - 0.000000000000000000002016 103.0
TLS2_k127_4753462_15 RNA recognition motif - - - 0.000000000000001657 81.0
TLS2_k127_4753462_16 Bacterial regulatory proteins, tetR family - - - 0.000000002038 59.0
TLS2_k127_4753462_2 RND efflux system, outer membrane lipoprotein - - - 4.983e-200 634.0
TLS2_k127_4753462_3 MlaD protein K06192 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 616.0
TLS2_k127_4753462_4 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 490.0
TLS2_k127_4753462_5 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 370.0
TLS2_k127_4753462_6 HlyD membrane-fusion protein of T1SS K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 351.0
TLS2_k127_4753462_7 Trypsin-like serine protease K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009488 307.0
TLS2_k127_4753462_8 Paraquat-inducible protein A K03808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000633 248.0
TLS2_k127_4753462_9 Paraquat-inducible protein A K03808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007218 252.0
TLS2_k127_4761112_0 Chain length determinant protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 549.0
TLS2_k127_4761112_1 Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 437.0
TLS2_k127_4761112_2 AAA domain K08252,K16692 - 2.7.10.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004795 372.0
TLS2_k127_4761112_3 - K13662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004551 366.0
TLS2_k127_4761112_4 Polysaccharide biosynthesis/export protein K01991 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006727 363.0
TLS2_k127_4761112_5 TIGRFAM peptidyl-prolyl cis-trans isomerase, EpsD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 338.0
TLS2_k127_4761112_6 Putative beta-barrel porin 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006534 308.0
TLS2_k127_4761112_7 Protein of unknown function (DUF3485) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002666 263.0
TLS2_k127_4770529_0 Flagellar basal body rod FlgEFG protein C-terminal K02396 - - 1.982e-198 637.0
TLS2_k127_4770529_1 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 485.0
TLS2_k127_4770529_10 Flagellar rod assembly protein muramidase FlgJ K02395 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003536 261.0
TLS2_k127_4770529_11 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.000000000000000000000000000000000000000000000000000000000000000002179 236.0
TLS2_k127_4770529_12 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.0000000000000000000000000000000000000000000000000000000001311 212.0
TLS2_k127_4770529_13 Flagellar hook capping protein - N-terminal region K02389 - - 0.0000000000000000000000000000000000000000000000000000004331 200.0
TLS2_k127_4770529_14 Belongs to the flagella basal body rod proteins family K02388 - - 0.00000000000000000000000000000000000000000000000001082 183.0
TLS2_k127_4770529_15 Role in flagellar biosynthesis K02420 - - 0.0000000000000000000000000000000000001312 144.0
TLS2_k127_4770529_16 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.000000000000000000000000000002253 127.0
TLS2_k127_4770529_17 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.00000000000000000000000000004257 119.0
TLS2_k127_4770529_18 - - - - 0.0000000000000000000000000004621 120.0
TLS2_k127_4770529_19 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.00000000000000000000000000531 110.0
TLS2_k127_4770529_2 Belongs to the flagella basal body rod proteins family K02392 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 403.0
TLS2_k127_4770529_20 FlgN protein K02399 - - 0.000000000000000001933 93.0
TLS2_k127_4770529_21 negative regulator of flagellin synthesis K02398 - - 0.00000000000001122 78.0
TLS2_k127_4770529_3 Flagellar hook protein FlgE K02390 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 405.0
TLS2_k127_4770529_4 flagellar motor K02556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 370.0
TLS2_k127_4770529_5 basal body rod protein K02391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 336.0
TLS2_k127_4770529_6 Flagellar motor protein K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 302.0
TLS2_k127_4770529_7 Belongs to the bacterial flagellin family K02397 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005254 287.0
TLS2_k127_4770529_8 Role in flagellar biosynthesis K02421 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003049 279.0
TLS2_k127_4770529_9 Plays a role in the flagellum-specific transport system K02419 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002963 261.0
TLS2_k127_4774776_0 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 5.995e-316 973.0
TLS2_k127_4774776_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 2.024e-241 752.0
TLS2_k127_4774776_10 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000000000000000000000000000004702 182.0
TLS2_k127_4774776_11 Ribosomal L27 protein K02899 - - 0.00000000000000000000000000000000000001356 145.0
TLS2_k127_4774776_12 Protein of unknown function (DUF3106) - - - 0.000000000000000000000000000001479 125.0
TLS2_k127_4774776_13 membrane protein domain - - - 0.000000000000000000000000000004374 125.0
TLS2_k127_4774776_14 Protein of unknown function (DUF3619) - - - 0.00000000000001723 79.0
TLS2_k127_4774776_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 8.096e-200 625.0
TLS2_k127_4774776_3 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 558.0
TLS2_k127_4774776_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 556.0
TLS2_k127_4774776_5 Permease YjgP YjgQ family K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 437.0
TLS2_k127_4774776_6 Permease YjgP YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008695 421.0
TLS2_k127_4774776_7 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 339.0
TLS2_k127_4774776_8 Acetolactate synthase small K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 282.0
TLS2_k127_4774776_9 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007599 274.0
TLS2_k127_4781836_0 AMP-binding enzyme K01897 - 6.2.1.3 3.82e-298 923.0
TLS2_k127_4781836_1 Histidine kinase K05962 - 2.7.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 468.0
TLS2_k127_4781836_10 - - - - 0.00000000005895 63.0
TLS2_k127_4781836_2 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 317.0
TLS2_k127_4781836_3 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 316.0
TLS2_k127_4781836_4 MlaC protein K07323 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003759 243.0
TLS2_k127_4781836_6 - - - - 0.00000000000000000000000000000000000000000002076 168.0
TLS2_k127_4781836_7 Pfam Response regulator receiver - - - 0.0000000000000000000000000000000000402 139.0
TLS2_k127_4781836_8 bacterial OsmY and nodulation domain - - - 0.00000000000000000000000000002065 120.0
TLS2_k127_4781836_9 EF hand - - - 0.0000000000009794 78.0
TLS2_k127_4783298_0 Acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 300.0
TLS2_k127_4783298_1 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000000003598 238.0
TLS2_k127_4783298_2 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000485 228.0
TLS2_k127_4783298_3 D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000000000000005796 203.0
TLS2_k127_4783298_4 Protein of unknown function DUF45 K07043 - - 0.00000000000164 74.0
TLS2_k127_4797479_0 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 542.0
TLS2_k127_4797479_1 Belongs to the radical SAM superfamily. RlmN family K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 472.0
TLS2_k127_4797479_2 RND efflux system, outer membrane lipoprotein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006946 464.0
TLS2_k127_4797479_3 Domain of unknown function (DUF4405) - - - 0.000000000000000000000000008218 117.0
TLS2_k127_4797479_4 - - - - 0.000000000009273 75.0
TLS2_k127_4801814_0 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004131 576.0
TLS2_k127_4801814_1 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 370.0
TLS2_k127_4811923_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 4.234e-200 627.0
TLS2_k127_4811923_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 475.0
TLS2_k127_4811923_2 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005014 468.0
TLS2_k127_4811923_3 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000002048 274.0
TLS2_k127_481197_0 Dehydrogenase E1 component K00164 - 1.2.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005318 553.0
TLS2_k127_481197_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007019 425.0
TLS2_k127_4817258_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1179.0
TLS2_k127_4817258_1 COG1450 Type II secretory pathway, component PulD K02453 - - 4.094e-212 681.0
TLS2_k127_4817258_10 General secretion pathway protein F K02455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 451.0
TLS2_k127_4817258_11 Male sterility protein K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 437.0
TLS2_k127_4817258_12 Polysaccharide chain length determinant protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000999 428.0
TLS2_k127_4817258_13 O-Antigen Polymerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005236 412.0
TLS2_k127_4817258_14 COG3267 Type II secretory pathway, component ExeA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008387 404.0
TLS2_k127_4817258_15 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 399.0
TLS2_k127_4817258_16 COG1596 Periplasmic protein involved in polysaccharide export K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004665 318.0
TLS2_k127_4817258_17 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 305.0
TLS2_k127_4817258_18 COG0489 ATPases involved in chromosome partitioning K08252 - 2.7.10.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005854 299.0
TLS2_k127_4817258_19 Type II secretion system (T2SS), protein K K02460 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002938 267.0
TLS2_k127_4817258_2 - - - - 2.437e-198 623.0
TLS2_k127_4817258_20 TIGRFAM PEP-CTERM system associated protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002247 270.0
TLS2_k127_4817258_21 FKBP-type peptidyl-prolyl cis-trans K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000001794 237.0
TLS2_k127_4817258_22 general secretion pathway protein G K02456 - - 0.000000000000000000000000000000000000000000000000000000000000001682 223.0
TLS2_k127_4817258_23 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000003361 221.0
TLS2_k127_4817258_24 Type II secretion system (T2SS), protein I K02458 - - 0.0000000000000000000000000000597 121.0
TLS2_k127_4817258_25 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.0000000000000000000000000001647 114.0
TLS2_k127_4817258_26 Type II secretion system (T2SS), protein J K02459 - - 0.000000000000000000000008585 109.0
TLS2_k127_4817258_28 PFAM General secretion pathway L K02461 - - 0.000000000000000005932 97.0
TLS2_k127_4817258_29 Prokaryotic N-terminal methylation motif K02457 - - 0.00000000000000001718 91.0
TLS2_k127_4817258_3 COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 7.491e-198 627.0
TLS2_k127_4817258_30 Glycosyltransferase Family 4 - - - 0.0000000000000000357 82.0
TLS2_k127_4817258_31 Type II secretion system protein C K02452 - - 0.0000000000005114 78.0
TLS2_k127_4817258_4 COG2148 Sugar transferases involved in lipopolysaccharide synthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 552.0
TLS2_k127_4817258_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 530.0
TLS2_k127_4817258_6 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008274 514.0
TLS2_k127_4817258_7 AFG1-like ATPase K06916 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009393 491.0
TLS2_k127_4817258_8 glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009039 474.0
TLS2_k127_4817258_9 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 460.0
TLS2_k127_4824580_0 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.236e-237 742.0
TLS2_k127_4824580_1 exodeoxyribonuclease iii K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009561 429.0
TLS2_k127_4824580_2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 312.0
TLS2_k127_4824580_3 dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000004736 248.0
TLS2_k127_4824580_4 NlpC/P60 family - - - 0.00000000000000000000000000000000000000000000000000000423 194.0
TLS2_k127_4824580_5 Bacterial protein of unknown function (DUF883) - - - 0.000000000000000000000000000000008731 130.0
TLS2_k127_4824580_6 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000000000000000000001263 104.0
TLS2_k127_4824580_7 YqjK-like protein - - - 0.0000000001107 68.0
TLS2_k127_4824580_8 - - - - 0.0000000009315 62.0
TLS2_k127_4829351_0 serine threonine protein kinase - - - 2.145e-300 941.0
TLS2_k127_4829351_1 His Kinase A (phosphoacceptor) domain K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007803 482.0
TLS2_k127_4829351_2 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 387.0
TLS2_k127_4829351_3 Hsp90 protein K04079 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 371.0
TLS2_k127_4829351_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000543 261.0
TLS2_k127_4839392_0 Belongs to the 5'-nucleotidase family K11751,K17224 - 3.1.3.5,3.6.1.45 4.999e-292 909.0
TLS2_k127_4839392_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 336.0
TLS2_k127_4839392_2 C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006579 258.0
TLS2_k127_4839392_3 abc transporter K02003,K05685 - - 0.0000000000000000000000000000000000000000000000000000000000000000653 224.0
TLS2_k127_4839392_4 Cytochrome c K17223 - - 0.000000000000000000000000000000000000000000000000000000000000001521 224.0
TLS2_k127_4839392_5 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000469 52.0
TLS2_k127_4840205_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 1.084e-230 728.0
TLS2_k127_4840205_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000001437 262.0
TLS2_k127_4840205_2 COG3209 Rhs family protein - - - 0.000000000000004185 79.0
TLS2_k127_4840205_4 RHS Repeat - - - 0.000003394 49.0
TLS2_k127_4840820_0 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 596.0
TLS2_k127_4840820_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009902 416.0
TLS2_k127_4840820_2 PIN domain - - - 0.0000000000000000000000000000000000000008833 153.0
TLS2_k127_4840820_3 transcriptional regulator K07172 - - 0.000000000000000000000001012 106.0
TLS2_k127_484712_0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 595.0
TLS2_k127_484712_1 Beta-ketoacyl synthase, C-terminal domain K00647 - 2.3.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 426.0
TLS2_k127_484712_2 FMN binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 325.0
TLS2_k127_484712_3 Butirosin biosynthesis protein H, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 287.0
TLS2_k127_484712_4 - - - - 0.0000000000000000000000000000000000000000000000000000000317 205.0
TLS2_k127_484712_5 - - - - 0.000000000000000000000000000000000000000000000001544 192.0
TLS2_k127_484712_6 Phosphopantetheine attachment site K02078 - - 0.0000000000000000000000000000000009662 131.0
TLS2_k127_4851858_0 GTP-binding protein TypA K06207 - - 0.0 1028.0
TLS2_k127_4851858_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 1.518e-293 929.0
TLS2_k127_4851858_2 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 2.741e-243 766.0
TLS2_k127_4851858_3 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009839 562.0
TLS2_k127_4851858_4 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 504.0
TLS2_k127_4851858_5 Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 360.0
TLS2_k127_4851858_6 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002111 254.0
TLS2_k127_4851858_7 phosphoribosyltransferase K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000003304 226.0
TLS2_k127_4856638_0 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 471.0
TLS2_k127_4856638_1 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 472.0
TLS2_k127_4863798_0 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000526 456.0
TLS2_k127_4863798_1 LysR substrate binding domain K03717 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 403.0
TLS2_k127_4863798_2 Belongs to the BI1 family K19416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 353.0
TLS2_k127_4863798_3 Na H antiporter K05559 - - 0.000000000000000000000000000001501 124.0
TLS2_k127_4863798_4 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000001198 65.0
TLS2_k127_4863821_0 Cysteine-rich domain K00113 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 451.0
TLS2_k127_4863821_1 aldehyde ferredoxin oxidoreductase activity K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 389.0
TLS2_k127_4863821_2 oxygen carrier activity K07216 - - 0.0000000000000000000000000000002217 127.0
TLS2_k127_4863821_3 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.000000000000000000000000000003674 121.0
TLS2_k127_4863821_4 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - 0.000000000000000000000000000004446 122.0
TLS2_k127_4863821_5 4Fe-4S binding domain - - - 0.00000000000000034 81.0
TLS2_k127_4889722_0 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 515.0
TLS2_k127_4889722_1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K06020 - 3.6.3.25 0.000000000000000001259 85.0
TLS2_k127_4911545_0 Bacterial protein of unknown function (DUF839) K07093 - - 1.237e-317 988.0
TLS2_k127_4911545_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004152 269.0
TLS2_k127_4911545_2 HNH nucleases - - - 0.000000000000000000000000000000000000000000000000000005277 194.0
TLS2_k127_4911545_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000000002431 181.0
TLS2_k127_4911545_4 Belongs to the pirin family K06911 - - 0.000000001734 58.0
TLS2_k127_491871_0 Oligopeptidase K01414 - 3.4.24.70 0.0 1027.0
TLS2_k127_491871_1 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities K14155 - 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 520.0
TLS2_k127_491871_2 Belongs to the SAICAR synthetase family K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 342.0
TLS2_k127_491871_3 exodeoxyribonuclease III K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000001537 204.0
TLS2_k127_491871_4 Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second- messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a - - - 0.00000000000000000000000001963 112.0
TLS2_k127_4924430_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.577e-243 767.0
TLS2_k127_4924430_1 Isocitrate lyase K01637 - 4.1.3.1 5.884e-214 665.0
TLS2_k127_4924430_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 2.056e-195 616.0
TLS2_k127_4924430_3 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005923 403.0
TLS2_k127_4924430_4 2-hydroxy-3-oxopropionate reductase K00042 - 1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003638 411.0
TLS2_k127_4924430_5 Tripartite ATP-independent periplasmic - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007563 312.0
TLS2_k127_4924430_6 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle K01638 - 2.3.3.9 0.000000000000000000000000000000000000000000000000000000000000000001878 228.0
TLS2_k127_4946336_0 aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 428.0
TLS2_k127_4946336_1 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007428 428.0
TLS2_k127_4956698_0 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 577.0
TLS2_k127_4956698_1 Single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 344.0
TLS2_k127_4956698_2 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000001075 218.0
TLS2_k127_4974877_0 Rhomboid family K19225 - 3.4.21.105 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000763 422.0
TLS2_k127_4974877_2 TIGRFAM Undecaprenyl-phosphate glucose phosphotransferase, WcaJ K03606 - - 0.000000000000000000000000000000000000000000000000005052 188.0
TLS2_k127_4980844_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 458.0
TLS2_k127_4980844_1 SMART beta-lactamase domain protein K01120 - 3.1.4.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 339.0
TLS2_k127_4980844_2 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002405 285.0
TLS2_k127_4980844_3 (FHA) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004958 264.0
TLS2_k127_4980844_4 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000008582 227.0
TLS2_k127_5066778_0 Belongs to the pseudouridine synthase RsuA family K06183 - 5.4.99.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 337.0
TLS2_k127_5066778_1 of ABC transporters with duplicated ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 308.0
TLS2_k127_5066778_2 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001107 267.0
TLS2_k127_5066778_3 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.00000000000000000000000000000000000000000000001273 172.0
TLS2_k127_5066778_4 - - - - 0.0000000000000000000000000000000000000000007591 163.0
TLS2_k127_5066778_5 - - - - 0.00000000000000000000006293 106.0
TLS2_k127_5066778_6 Protein of unknown function (DUF2789) - - - 0.0000000000000000003729 94.0
TLS2_k127_50711_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 1.061e-211 671.0
TLS2_k127_50711_1 Predicted membrane protein (DUF2238) K08984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004876 276.0
TLS2_k127_50711_2 membrane protein, hemolysin III homolog K11068 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001014 265.0
TLS2_k127_50711_3 cytochrome - - - 0.00000000000000000000000000000000000001356 149.0
TLS2_k127_5085158_2 PFAM beta-lactamase - - - 0.0000003795 54.0
TLS2_k127_5094389_0 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 338.0
TLS2_k127_5094389_1 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004595 288.0
TLS2_k127_5094389_2 Protein of unknown function, DUF481 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002537 250.0
TLS2_k127_5094389_3 Belongs to the UPF0178 family K09768 - - 0.00000000000000000000000000000000000000000000000000000000000000000001021 237.0
TLS2_k127_5094389_4 Transcriptional regulator K03566 - - 0.000000000000000000000000000000000000000000000000000005277 194.0
TLS2_k127_5094389_5 - - - - 0.00000001712 57.0
TLS2_k127_5129766_0 PFAM Xylulose 5-phosphate Fructose 6-phosphate phosphoketolase, N-terminal K01621 GO:0003674,GO:0003824,GO:0008150,GO:0009758 4.1.2.22,4.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 494.0
TLS2_k127_5129766_1 ADP-ribosyl- dinitrogen reductase hydrolase K05521 - 3.2.2.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009875 369.0
TLS2_k127_5136655_0 AAA domain K07133 - - 3.989e-271 838.0
TLS2_k127_5136655_1 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000146 184.0
TLS2_k127_5136655_2 Part of a membrane complex involved in electron transport K03617 - - 0.000000000000000000006638 92.0
TLS2_k127_5136655_3 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.000000000000000000006889 93.0
TLS2_k127_5136655_4 - - - - 0.00000002815 59.0
TLS2_k127_5147537_0 Eco57I restriction-modification methylase K07317 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 462.0
TLS2_k127_5147537_1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 399.0
TLS2_k127_5147537_2 glutamate--cysteine ligase K01919 - 6.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005105 392.0
TLS2_k127_5157613_0 Cytochrome b/b6/petB K00412,K03888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008514 251.0
TLS2_k127_5157613_1 Cytochrome b(C-terminal)/b6/petD K00412 - - 0.00000000000000007033 94.0
TLS2_k127_5157613_2 Cytochrome c - - - 0.00003936 56.0
TLS2_k127_5179938_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 513.0
TLS2_k127_5179938_1 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006674 474.0
TLS2_k127_5179938_2 signal transduction protein containing EAL and modified HD-GYP - - - 0.000000000000000000000000000000000000000000000000000002182 199.0
TLS2_k127_5195254_0 epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009769 274.0
TLS2_k127_5195254_1 Belongs to the methyltransferase superfamily K07444 - - 0.0000000000000000000000000000000000000000000000000000000000000009946 222.0
TLS2_k127_5195254_2 membrane K08973 - - 0.0000000000000000000000000000000000000000000000000000004426 207.0
TLS2_k127_5195254_3 Large family of predicted nucleotide-binding domains - - - 0.000000000000000248 87.0
TLS2_k127_5195254_4 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.000005756 52.0
TLS2_k127_5206178_0 Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility - - - 0.000000000000000000000000000000000000000000000000000000000000000000002172 244.0
TLS2_k127_5206178_1 Flagellar hook-length control protein FliK - - - 0.000000000000000000000000000000000000000000000000000000001078 215.0
TLS2_k127_5206178_2 PFAM Flagellar protein FliS K02422 - - 0.000000000000000000000000000000000000000002177 159.0
TLS2_k127_5206178_3 homolog of the cytoplasmic domain of flagellar protein FhlB K04061 - - 0.000000000000000000000000000000003085 131.0
TLS2_k127_5206178_4 Flagellar hook-basal body K02408 - - 0.00000000000000000000000000000001504 129.0
TLS2_k127_5206178_5 Flagellar protein FliT K02423 - - 0.00000000000000005641 86.0
TLS2_k127_5206178_6 Flagellar protein FliT K02423 - - 0.0000000000001194 75.0
TLS2_k127_5206178_7 Flagellar hook-associated protein 2 N-terminus K02407 - - 0.000001775 51.0
TLS2_k127_5234457_0 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 9.279e-194 612.0
TLS2_k127_5234457_1 A domain family that is part of the cupin metalloenzyme superfamily. K18850 - 1.14.11.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008316 456.0
TLS2_k127_5234457_11 - - - - 0.00000001803 58.0
TLS2_k127_5234457_2 (Lipo)protein K07287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 453.0
TLS2_k127_5234457_3 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 441.0
TLS2_k127_5234457_4 Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 340.0
TLS2_k127_5234457_5 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009366 331.0
TLS2_k127_5234457_6 synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000001404 252.0
TLS2_k127_5234457_7 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000005112 152.0
TLS2_k127_5234457_8 Transcriptional regulator - - - 0.000000000000000000000000000000000000001334 149.0
TLS2_k127_5234457_9 - - - - 0.0000000000000000000001335 103.0
TLS2_k127_5246765_0 Sodium:solute symporter family K14393 - - 9.748e-313 971.0
TLS2_k127_5246765_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 579.0
TLS2_k127_5246765_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 319.0
TLS2_k127_5246765_3 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000002408 226.0
TLS2_k127_5246765_4 Domain of unknown function (DUF4212) - - - 0.00000000000000000000000000000000001147 139.0
TLS2_k127_5246765_5 - - - - 0.000000000000000000000000000002044 124.0
TLS2_k127_5246765_6 - - - - 0.000000000000000000000000000002831 126.0
TLS2_k127_5246765_7 Glycine-zipper domain - - - 0.0000000000000000000000000007434 122.0
TLS2_k127_5246765_8 Two-component sensor kinase N-terminal K07649 - 2.7.13.3 0.000000000000000000003918 94.0
TLS2_k127_5294128_0 abc transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004373 381.0
TLS2_k127_5294128_1 ROK family K00847 - 2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 347.0
TLS2_k127_5307300_0 COG0119 Isopropylmalate homocitrate citramalate synthases K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 421.0
TLS2_k127_5307300_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 370.0
TLS2_k127_5307300_2 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 0.00000000001074 64.0
TLS2_k127_5310972_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1069.0
TLS2_k127_5310972_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 372.0
TLS2_k127_5310972_10 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 0.00000000000000000000000001139 113.0
TLS2_k127_5310972_11 Ribosomal protein L35 K02916 - - 0.0000000000000000000002097 99.0
TLS2_k127_5310972_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007094 381.0
TLS2_k127_5310972_3 cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 329.0
TLS2_k127_5310972_4 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003823 273.0
TLS2_k127_5310972_5 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000000000000000000000000001108 205.0
TLS2_k127_5310972_6 cytochrome c oxidase, subunit III K02276 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 0.00000000000000000000000000000000000000000000004183 179.0
TLS2_k127_5310972_7 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000001183 161.0
TLS2_k127_5310972_8 PFAM cytochrome c - - - 0.000000000000000000000000000000000000002526 155.0
TLS2_k127_5310972_9 protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000007608 138.0
TLS2_k127_5427834_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002928 433.0
TLS2_k127_5427834_1 GAF domain - - - 0.000000000000000000000000000000001291 141.0
TLS2_k127_5427834_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000004776 106.0
TLS2_k127_5427834_3 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000004329 51.0
TLS2_k127_5441579_0 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 544.0
TLS2_k127_5441579_1 DJ-1/PfpI family K05520 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 329.0
TLS2_k127_5441579_2 Ribbon-helix-helix domain - - - 0.00000000000000000000000000000000000000001728 156.0
TLS2_k127_5441579_3 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.0000122 48.0
TLS2_k127_5458388_0 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 4.724e-308 966.0
TLS2_k127_5458388_1 Catalyzes the formation of 2-oxoglutarate from isocitrate K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 535.0
TLS2_k127_5458388_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008724 425.0
TLS2_k127_5458388_3 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 351.0
TLS2_k127_5458388_4 DNA polymerase III K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002045 285.0
TLS2_k127_5458388_5 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000204 269.0
TLS2_k127_5458388_6 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000000000002051 205.0
TLS2_k127_5458388_7 pilus assembly protein PilZ K02676 - - 0.0000000000000000000000000000000000000000000000009806 177.0
TLS2_k127_5458388_8 ankyrin repeat K06867 - - 0.0000000000000000000000000000000000002913 149.0
TLS2_k127_5458388_9 Belongs to the GcvT family K06980 - - 0.000004904 51.0
TLS2_k127_5485072_0 TIGRFAM Molybdate ABC transporter K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005888 361.0
TLS2_k127_5485072_1 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0099133 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 346.0
TLS2_k127_5485072_2 NifQ K15790 - - 0.00000000000000000000000000000003627 125.0
TLS2_k127_549796_0 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 389.0
TLS2_k127_5542072_0 LysE type translocator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002734 281.0
TLS2_k127_5542072_1 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.000000000000000000000000000000000000000000000000156 184.0
TLS2_k127_5542072_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000003909 155.0
TLS2_k127_5574883_0 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 428.0
TLS2_k127_5574883_1 Major facilitator Superfamily - - - 0.00000000000000000000000000000000002257 138.0
TLS2_k127_5584183_0 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00956 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 443.0
TLS2_k127_5584183_1 Transcriptional regulator K13635 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 350.0
TLS2_k127_5584183_2 DsrC like protein K11179 - - 0.00000000000000000000000000000000000000000001885 164.0
TLS2_k127_5584183_3 DNA-binding transcription factor activity K03892,K07721,K22042 - - 0.0000000000000000000007406 100.0
TLS2_k127_5585806_0 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K06020 - 3.6.3.25 5.099e-264 817.0
TLS2_k127_5585806_1 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006326 332.0
TLS2_k127_5585806_2 - - - - 0.000000000000000000000000000000000000000000000000000006998 199.0
TLS2_k127_5585806_3 - - - - 0.00000000000000000000000000002119 132.0
TLS2_k127_5598536_0 Pyruvate ferredoxin/flavodoxin oxidoreductase K04090 - 1.2.7.8 0.0 1323.0
TLS2_k127_5598536_1 His Kinase A (phosphoacceptor) domain - - - 6.793e-267 831.0
TLS2_k127_5598536_2 Diguanylate cyclase - - - 2.02e-260 820.0
TLS2_k127_5598536_3 5'-nucleotidase K01081 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 452.0
TLS2_k127_5598536_4 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007387 415.0
TLS2_k127_5598536_5 - - - - 0.00000000000000000000000000000000000000000000000000991 200.0
TLS2_k127_56158_0 His Kinase A (phosphoacceptor) domain K15011 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 370.0
TLS2_k127_56158_1 PFAM NnrS family protein K07234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009553 297.0
TLS2_k127_56158_2 COG4567 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain K15012 - - 0.0000000000000000000000000000000000000000000000000000000000000001172 244.0
TLS2_k127_56158_3 SCO1/SenC K07152 - - 0.00000000000000000000000000000000000000000000000000000061 207.0
TLS2_k127_56158_4 Copper chaperone PCu(A)C K09796 - - 0.00000000000000000000000000000000000000000001293 176.0
TLS2_k127_56158_5 - - - - 0.00000000000000000000000000000000000000000317 160.0
TLS2_k127_56158_6 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00000000000000000000000000000000000003679 144.0
TLS2_k127_56158_7 Helix-turn-helix K21498 - - 0.000000000000000000000000001648 114.0
TLS2_k127_56158_8 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 0.000004452 58.0
TLS2_k127_5627300_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 9.553e-262 821.0
TLS2_k127_5628463_0 transferase activity, transferring glycosyl groups K13659 - 2.4.1.264 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 503.0
TLS2_k127_5628463_1 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 431.0
TLS2_k127_5628463_2 Glycosyltransferase Family 4 K13657 - 2.4.1.252 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 390.0
TLS2_k127_5628463_3 Glycosyl transferase WecB/TagA/CpsF family K05946,K13660 - 2.4.1.187 0.00000000000000000000000000000000000437 142.0
TLS2_k127_5630225_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 1.543e-236 747.0
TLS2_k127_5630225_1 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 560.0
TLS2_k127_5630225_2 Phosphotransferase System K11189 - - 0.0000000000000000000000000005665 113.0
TLS2_k127_5630513_0 Nitrite and sulphite reductase 4Fe-4S domain K11180 - 1.8.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000727 254.0
TLS2_k127_5630513_1 Sulfurtransferase TusA - - - 0.000000000000000000000000000000000000000000000001513 178.0
TLS2_k127_5630513_2 DsrC like protein K11179 - - 0.0000000000000000000000000000000003881 134.0
TLS2_k127_5630513_3 Cas6 Crispr - - - 0.000000000000000000000000000001903 129.0
TLS2_k127_5630513_4 - - - - 0.00000000000000000000000343 106.0
TLS2_k127_5630513_5 - - - - 0.000000000000000000001513 96.0
TLS2_k127_5633920_0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 6.366e-253 785.0
TLS2_k127_5633920_1 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000769 224.0
TLS2_k127_5637511_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 7.485e-241 756.0
TLS2_k127_5637511_1 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000002557 212.0
TLS2_k127_5637511_2 Smr protein MutS2 - - - 0.0000000000000000000000000000000000000000000000000000000002715 207.0
TLS2_k127_5637511_3 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000002826 99.0
TLS2_k127_5639895_0 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004287 313.0
TLS2_k127_5639895_1 PFAM cytochrome B561 K12262 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000799 286.0
TLS2_k127_5639895_2 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000000000000000000000000000001 225.0
TLS2_k127_5663969_0 Protein of unknown function (DUF3047) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006773 303.0
TLS2_k127_5663969_1 Glycosyl transferase group 2 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002969 284.0
TLS2_k127_5663969_2 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003442 250.0
TLS2_k127_5663969_3 pyridine nucleotide-disulfide oxidoreductase family protein K17218 - 1.8.5.4 0.0000000000000000000000696 98.0
TLS2_k127_5663969_4 Plasmid stabilization system - - - 0.00000000006415 70.0
TLS2_k127_5677223_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 406.0
TLS2_k127_5677223_1 catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006851 345.0
TLS2_k127_5677223_2 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 293.0
TLS2_k127_5677223_3 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004465 244.0
TLS2_k127_5677223_4 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000000000000000000000000000006516 211.0
TLS2_k127_5677223_5 - - - - 0.0000000000001226 74.0
TLS2_k127_5683617_0 Bifunctional enoyl-CoA hydratase phosphate acetyltransferase K00625 - 2.3.1.8 2.281e-211 666.0
TLS2_k127_5683617_1 Glycosyl transferase family 41 - - - 3.441e-195 642.0
TLS2_k127_5683617_2 GGDEF domain K13590 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008756 602.0
TLS2_k127_5683617_3 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 582.0
TLS2_k127_5683617_4 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007044 504.0
TLS2_k127_5683617_5 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00436 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007889 437.0
TLS2_k127_5683617_6 Histidine kinase K07675 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 434.0
TLS2_k127_5683617_7 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 295.0
TLS2_k127_5683617_8 Bacterial transferase hexapeptide (six repeats) K21379 - 2.3.1.209 0.000000000000000000000000000000000000000000000000000000000000000000000004987 248.0
TLS2_k127_5683617_9 maturation - - - 0.0000000000000000000000000000000000000000000000000005754 188.0
TLS2_k127_5688460_0 methionine synthase K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001774 279.0
TLS2_k127_5688460_1 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000001146 217.0
TLS2_k127_5688460_2 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000002535 157.0
TLS2_k127_5688460_3 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000001428 155.0
TLS2_k127_5694424_0 fad dependent oxidoreductase K07137 - - 5.575e-263 818.0
TLS2_k127_5694424_1 Belongs to the methyltransferase superfamily K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 504.0
TLS2_k127_5694424_2 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000002205 263.0
TLS2_k127_5694424_3 Belongs to the UPF0225 family K09858 - - 0.000000000000000000000000000000000000000000000000002005 184.0
TLS2_k127_5694424_4 Transglycosylase SLT domain K08305 - - 0.0000000000000004715 78.0
TLS2_k127_5705711_0 Diguanylate cyclase - - - 2.645e-231 736.0
TLS2_k127_5705711_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 294.0
TLS2_k127_5705711_2 translation initiation factor activity K03086 - - 0.000000000000000001152 96.0
TLS2_k127_5713031_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 7.141e-222 694.0
TLS2_k127_5713031_1 glycolate oxidase subunit GlcD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 600.0
TLS2_k127_5713031_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K00023 - 1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 440.0
TLS2_k127_5713031_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00023 - 1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009564 429.0
TLS2_k127_5713031_4 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 378.0
TLS2_k127_5713031_5 Poly(R)-hydroxyalkanoic acid synthase, class I K03821 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 323.0
TLS2_k127_5713031_6 synthesis repressor, PhaR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009787 287.0
TLS2_k127_5713031_7 Putative beta-barrel porin 2 - - - 0.00000000000000000000000000000000000000000000001075 178.0
TLS2_k127_5720371_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 9.192e-225 702.0
TLS2_k127_5720371_1 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007017 589.0
TLS2_k127_5720371_2 ZIP Zinc transporter K16267 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 424.0
TLS2_k127_5720371_3 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 301.0
TLS2_k127_5720371_4 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000002208 244.0
TLS2_k127_5720371_5 Protein of unknown function (DUF2796) - - - 0.000000000000000000000000000000000000000000000000000000004011 205.0
TLS2_k127_5720371_6 Flagellar protein YcgR - - - 0.000000000000000000000000000000000000000000000000000000004509 209.0
TLS2_k127_5720371_7 response to antibiotic - - - 0.0000000000000000000000000000000000000000000000000002168 200.0
TLS2_k127_5720371_8 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.000000000000000000000000000000000000000002642 156.0
TLS2_k127_5720371_9 Ferric uptake regulator family K03711 - - 0.0000000000000000000000000000002548 137.0
TLS2_k127_5730099_0 COG0564 Pseudouridylate synthases, 23S RNA-specific K06175 - 5.4.99.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 326.0
TLS2_k127_5730099_1 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 290.0
TLS2_k127_5730099_2 Glycine zipper 2TM domain - - - 0.000000000000234 77.0
TLS2_k127_5738417_0 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 421.0
TLS2_k127_5738417_1 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000001009 180.0
TLS2_k127_5745484_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 4.146e-194 613.0
TLS2_k127_5745484_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000002906 169.0
TLS2_k127_5760608_0 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01908 - 6.2.1.17 1.75e-288 890.0
TLS2_k127_5760608_1 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 299.0
TLS2_k127_5760608_2 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000001299 226.0
TLS2_k127_5794589_0 Cohesin domain K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009118 619.0
TLS2_k127_5794589_1 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 0.0000000000000000000000000000002695 124.0
TLS2_k127_5794589_2 - - - - 0.0000000000000000000000000000003751 132.0
TLS2_k127_5794589_3 - - - - 0.00000000000000000000000003258 119.0
TLS2_k127_5794589_4 carbon utilization K02664,K02665 - - 0.00000000000000000002377 101.0
TLS2_k127_5794589_5 - - - - 0.0000000000000000001685 96.0
TLS2_k127_5806208_0 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) K05951 - 2.4.2.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 373.0
TLS2_k127_5806208_1 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 354.0
TLS2_k127_5806208_3 - - - - 0.0000000000000000000007749 97.0
TLS2_k127_582246_0 recombinase XerD K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 381.0
TLS2_k127_582246_1 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005408 264.0
TLS2_k127_582246_2 COG0350 Methylated DNA-protein cysteine methyltransferase K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000009072 221.0
TLS2_k127_582246_3 Transcriptional regulator K13634 - - 0.00000000000000000000000000000000000000000000004536 172.0
TLS2_k127_582246_4 Domain of unknown function (DUF1850) - - - 0.000000000000000000000000000000000000000001921 161.0
TLS2_k127_582246_5 transport system, fused permease components - - - 0.00000000000006467 72.0
TLS2_k127_5823847_0 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000389 463.0
TLS2_k127_5823847_1 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 412.0
TLS2_k127_5823847_2 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008614 373.0
TLS2_k127_5823847_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 372.0
TLS2_k127_5823847_4 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.000000000000000000000000000000001427 130.0
TLS2_k127_5823847_5 Protein of unknown function (DUF2892) - - - 0.000000000000000000000001191 105.0
TLS2_k127_5854375_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 1.715e-257 809.0
TLS2_k127_5854375_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 571.0
TLS2_k127_5854375_2 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 363.0
TLS2_k127_5854375_3 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.00000000000000000000000000000000000001797 146.0
TLS2_k127_5854375_4 tryptophan synthase subunit beta - - - 0.000000000000000000003545 99.0
TLS2_k127_5856736_0 Cytochrome c bacterial - - - 6.004e-213 667.0
TLS2_k127_5856736_1 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007122 345.0
TLS2_k127_5856736_2 Uncharacterized protein conserved in bacteria (DUF2141) - - - 0.0000000000000000000000000000000000000000000002344 172.0
TLS2_k127_5873495_0 AAA domain, putative AbiEii toxin, Type IV TA system K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 355.0
TLS2_k127_5873495_1 hydrolase of the alpha beta superfamily K07018 - - 0.000000000000000000000000000000000000000000000000000000000000000000008031 243.0
TLS2_k127_5873495_2 Ferredoxin - - - 0.000000000000000000000000000000000000000000006262 164.0
TLS2_k127_5873495_3 ABC-2 type transporter K09694 - - 0.0000000000000000000004349 108.0
TLS2_k127_5908907_0 PFAM Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase - - - 0.0 1294.0
TLS2_k127_5908907_1 SMART PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 545.0
TLS2_k127_5908907_2 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 524.0
TLS2_k127_5908907_3 Desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008488 282.0
TLS2_k127_5908907_4 - - - - 0.0000000000000001752 85.0
TLS2_k127_5908907_5 alcohol dehydrogenase K00001 - 1.1.1.1 0.0000000000000008811 79.0
TLS2_k127_5909589_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 1.042e-195 614.0
TLS2_k127_5909589_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000003548 217.0
TLS2_k127_5909589_2 diguanylate cyclase activity - - - 0.000000000000000000000000000001457 129.0
TLS2_k127_5913100_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 3.969e-251 779.0
TLS2_k127_5913100_1 May be involved in recombination K03554 - - 0.000000000000000000000000000000000000000000000000000000000006989 212.0
TLS2_k127_5913100_2 Diguanylate cyclase - - - 0.00000001408 56.0
TLS2_k127_5914448_0 Cysteine-rich domain - - - 2.789e-262 812.0
TLS2_k127_5914448_1 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008509 270.0
TLS2_k127_5914448_2 Protein of unknown function (DUF3501) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005155 259.0
TLS2_k127_5914448_3 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000000000205 174.0
TLS2_k127_5942570_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 580.0
TLS2_k127_5942570_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004604 449.0
TLS2_k127_5967845_0 alpha/beta hydrolase fold K07019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004159 453.0
TLS2_k127_5967845_1 ubiE/COQ5 methyltransferase family K00570 - 2.1.1.17,2.1.1.71 0.000000000000000000000000000000000000000000000000000000000000000000000001095 256.0
TLS2_k127_5967845_2 protein affecting Mg2 Co2 transport K06195 - - 0.00000000000000000000000000000000000000000000000000009879 188.0
TLS2_k127_5967845_3 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000004973 185.0
TLS2_k127_5967845_4 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000001814 178.0
TLS2_k127_5981429_0 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 529.0
TLS2_k127_5981429_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007054 321.0
TLS2_k127_5981429_2 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002543 269.0
TLS2_k127_5981429_3 PKD domain - - - 0.000000000000000000000000000000000000000000009277 184.0
TLS2_k127_5981429_4 nucleic acid phosphodiester bond hydrolysis K07460 - - 0.000000000000000000000000000000000003941 153.0
TLS2_k127_5981429_5 - - - - 0.0000000000000000007768 91.0
TLS2_k127_5981429_7 - - - - 0.00000004449 59.0
TLS2_k127_5982596_0 Histidine kinase - - - 0.0 1263.0
TLS2_k127_5997753_0 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 K15461 - 2.1.1.61 1.362e-198 635.0
TLS2_k127_5997753_1 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000008684 211.0
TLS2_k127_6003232_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 412.0
TLS2_k127_6003232_1 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009411 369.0
TLS2_k127_6003232_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000001699 231.0
TLS2_k127_6003232_3 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.000000000000000000000000000000000000115 151.0
TLS2_k127_6006455_0 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 2.109e-240 758.0
TLS2_k127_6006455_1 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 574.0
TLS2_k127_6006455_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 457.0
TLS2_k127_6006455_3 pyridine nucleotide-disulfide oxidoreductase family protein K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005317 387.0
TLS2_k127_6006455_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003966 266.0
TLS2_k127_6006455_5 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001819 248.0
TLS2_k127_6006455_6 Phosphoglycerate mutase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001389 245.0
TLS2_k127_6006455_7 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.000000000000000000000000000000000000000001194 160.0
TLS2_k127_6006455_8 Esterase PHB depolymerase K03932 - - 0.0000000000000000000000000000000000000005208 164.0
TLS2_k127_6023269_0 Isochorismatase family - - - 0.0000000000000000000000000000000000000002011 150.0
TLS2_k127_6023269_1 cytochrome C peroxidase - - - 0.00000000000000000000000000000000000000133 158.0
TLS2_k127_6023869_0 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second K01958 - 6.4.1.1 5.718e-265 823.0
TLS2_k127_6023869_1 MASE1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003002 252.0
TLS2_k127_6023869_2 PFAM regulatory protein LuxR K13041 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004408 244.0
TLS2_k127_6023869_3 PFAM Hemerythrin HHE cation binding domain K07216 - - 0.00000000000000001435 89.0
TLS2_k127_6031594_0 PFAM C4-dicarboxylate transporter malic acid transport protein K03304 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005168 402.0
TLS2_k127_6031594_1 DNA topoisomerase III K03169 - 5.99.1.2 0.00000000000000000000000000000000000000000000006489 171.0
TLS2_k127_6031594_2 - - - - 0.000000000000000000002899 102.0
TLS2_k127_6031594_3 - - - - 0.00000000000000000002236 92.0
TLS2_k127_6031594_4 Lysin motif - - - 0.0000000000000000008978 89.0
TLS2_k127_6040125_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 2.079e-201 634.0
TLS2_k127_6040125_1 Methyl-accepting chemotaxis protein K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007112 616.0
TLS2_k127_6040125_2 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 453.0
TLS2_k127_6040125_3 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001941 286.0
TLS2_k127_6040125_4 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000002193 260.0
TLS2_k127_6040125_5 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000000000000000000000000009157 218.0
TLS2_k127_6040125_6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.00000000000000000000000000000000000000000000000000000001068 213.0
TLS2_k127_6040125_7 Thioesterase domain K02170 - 3.1.1.85 0.0000000000000000000000000000000000000003818 169.0
TLS2_k127_6078608_0 pyridine nucleotide-disulphide oxidoreductase K17218 GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0005515,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0042802,GO:0044237,GO:0045333,GO:0055114 1.8.5.4 4.396e-228 711.0
TLS2_k127_6078608_1 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 361.0
TLS2_k127_6078608_2 enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 319.0
TLS2_k127_6078608_3 transcriptional - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005436 275.0
TLS2_k127_6078608_4 Haloacid dehalogenase-like hydrolase K20881 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009006 276.0
TLS2_k127_6078608_5 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006172 259.0
TLS2_k127_6078608_6 Protein of unknown function (DUF2868) - - - 0.00000000000000000000000000000000000000000000000000000000005323 213.0
TLS2_k127_6078608_7 DsrE/DsrF-like family K09004 - - 0.000000000000000000000000000000003335 143.0
TLS2_k127_6078608_8 - - - - 0.0000000000000003815 79.0
TLS2_k127_6103905_0 UPF0313 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 295.0
TLS2_k127_6103905_1 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000001799 205.0
TLS2_k127_6103905_2 DsrC like protein - - - 0.000000000000000000000000000000000000000004665 157.0
TLS2_k127_6103905_3 - - - - 0.0000000000000000000000001385 109.0
TLS2_k127_613264_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 3.534e-234 729.0
TLS2_k127_613264_1 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 590.0
TLS2_k127_613264_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 388.0
TLS2_k127_613264_3 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 354.0
TLS2_k127_6139044_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1360.0
TLS2_k127_6139044_1 NADH:flavin oxidoreductase / NADH oxidase family K00219 - 1.3.1.34 1.011e-317 984.0
TLS2_k127_6139044_2 Formate dehydrogenase N, transmembrane K00124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 533.0
TLS2_k127_6139044_3 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000667 317.0
TLS2_k127_6139044_4 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000147 193.0
TLS2_k127_6139044_5 Prokaryotic cytochrome b561 K00127 - - 0.000000000000000000000000000000003069 128.0
TLS2_k127_6148978_0 PFAM Aminotransferase class I and II K14267 - 2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 527.0
TLS2_k127_6148978_1 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007884 305.0
TLS2_k127_6148978_2 QueF-like protein - - - 0.000000000000000000000000000000000000000000000009509 171.0
TLS2_k127_6176900_0 cyclic-guanylate-specific phosphodiesterase activity - - - 6.72e-200 649.0
TLS2_k127_6176900_1 Helix-turn-helix type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 363.0
TLS2_k127_6176900_10 Protein of unknown function (DUF465) - - - 0.0000000000000006731 84.0
TLS2_k127_6176900_11 Protein of unknown function (DUF3617) - - - 0.000000008829 64.0
TLS2_k127_6176900_12 - - - - 0.0000002055 54.0
TLS2_k127_6176900_2 High-affinity nickel-transport protein K07241 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006314 329.0
TLS2_k127_6176900_3 NADH dehydrogenase NAD(P)H nitroreductase K09019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005731 248.0
TLS2_k127_6176900_4 Transcriptional regulator K07722 - - 0.00000000000000000000000000000000000000000000000000000000000000002587 226.0
TLS2_k127_6176900_5 PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding K07226 - - 0.0000000000000000000000000000000000000000009775 164.0
TLS2_k127_6176900_6 - - - - 0.000000000000000000000000001373 119.0
TLS2_k127_6176900_7 Ni,Fe-hydrogenase I large subunit - - - 0.00000000000000000000001122 111.0
TLS2_k127_6176900_8 diguanylate cyclase - - - 0.000000000000000026 86.0
TLS2_k127_6176900_9 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406,K05874 - - 0.0000000000000003627 86.0
TLS2_k127_6200116_0 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008155 516.0
TLS2_k127_6200116_1 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 383.0
TLS2_k127_6200116_2 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.0000000000000000000000006147 106.0
TLS2_k127_6240679_0 Nitric oxide reductase large subunit K04561 - 1.7.2.5 5.684e-252 790.0
TLS2_k127_6240679_1 COG0714 MoxR-like ATPases K04748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 313.0
TLS2_k127_6240679_2 Cytochrome c K02305 - - 0.00000000000000000000000000000000000000000008858 163.0
TLS2_k127_6250351_0 PrkA family serine protein kinase K07180 - - 0.0 1151.0
TLS2_k127_6250351_1 Putative diguanylate phosphodiesterase - - - 0.0 1043.0
TLS2_k127_6250351_10 Na H antiporter, MnhB K05566 - - 0.00000000000000000000000000403 112.0
TLS2_k127_6250351_11 Domain of unknown function (DUF4040) - - - 0.00000000000000000001688 98.0
TLS2_k127_6250351_12 Protein of unknown function (DUF1161) - - - 0.00000000000000009444 81.0
TLS2_k127_6250351_13 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.0000000000000128 76.0
TLS2_k127_6250351_2 Ferrous iron transport protein B K04759 - - 5.023e-282 882.0
TLS2_k127_6250351_3 SpoVR family - - - 1.601e-258 807.0
TLS2_k127_6250351_4 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 1.413e-241 752.0
TLS2_k127_6250351_5 helicase K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 556.0
TLS2_k127_6250351_6 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 447.0
TLS2_k127_6250351_7 Na H antiporter K05569 - - 0.00000000000000000000000000000000000000000000000000000000198 204.0
TLS2_k127_6250351_8 Protein of Unknown function (DUF2784) - - - 0.00000000000000000000000000000000000000001301 166.0
TLS2_k127_6250351_9 monovalent cation proton antiporter, MnhG PhaG subunit - - - 0.0000000000000000000000000000000000000001254 153.0
TLS2_k127_6266205_0 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009464 580.0
TLS2_k127_6266205_1 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000007344 170.0
TLS2_k127_6266205_2 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000002782 160.0
TLS2_k127_6331874_0 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002932 608.0
TLS2_k127_6331874_1 amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 561.0
TLS2_k127_6331874_2 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002436 286.0
TLS2_k127_6331874_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000000000000000000000000000000000000000000004494 221.0
TLS2_k127_6331874_4 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000000000000000000000000002468 205.0
TLS2_k127_6331874_5 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000001657 187.0
TLS2_k127_6331874_6 addiction module killer protein - - - 0.00000000000000000000000000000000000000000000000004799 183.0
TLS2_k127_6331874_7 TonB C terminal K03646 - - 0.000000000000000000000000000000000000000000000001749 185.0
TLS2_k127_6331874_8 Biopolymer transport protein ExbD TolR K03560 - - 0.0000000000000000000000000000000003531 134.0
TLS2_k127_6334582_0 Dehydrogenase E1 component K00164 - 1.2.4.2 7.382e-303 941.0
TLS2_k127_6334582_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004123 516.0
TLS2_k127_634682_0 Belongs to the ClpA ClpB family K03694 - - 1.199e-308 951.0
TLS2_k127_634682_1 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000057 272.0
TLS2_k127_634682_2 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000001272 76.0
TLS2_k127_6401693_0 Belongs to the thiolase family K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 367.0
TLS2_k127_6401693_1 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000005031 216.0
TLS2_k127_6401693_2 Glutamate synthase - - - 0.0000000000000000000000000000000001314 134.0
TLS2_k127_6401693_3 - - - - 0.000000001809 63.0
TLS2_k127_640401_0 ABC transporter K06158 - - 3.385e-317 978.0
TLS2_k127_640401_1 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007116 278.0
TLS2_k127_64480_0 Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 371.0
TLS2_k127_64480_1 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004804 350.0
TLS2_k127_64480_2 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000001674 223.0
TLS2_k127_6475605_0 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 604.0
TLS2_k127_6475605_1 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000036 276.0
TLS2_k127_6475605_2 Carbohydrate phosphorylase K00688 - 2.4.1.1 0.000000000000000000000000000000004856 130.0
TLS2_k127_6535837_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000805 431.0
TLS2_k127_6535837_1 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004296 327.0
TLS2_k127_6535837_2 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000008806 199.0
TLS2_k127_6535837_3 - - - - 0.00000000000000000000000000000003663 130.0
TLS2_k127_6535837_4 - - - - 0.00000000000000000000007045 105.0
TLS2_k127_6544679_0 type II secretion system protein K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005334 516.0
TLS2_k127_6544679_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 322.0
TLS2_k127_6544679_2 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454,K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 285.0
TLS2_k127_6544679_3 - - - - 0.000000000000000000000000000000000008543 149.0
TLS2_k127_6544679_4 - - - - 0.0000000000000000000000000000002537 136.0
TLS2_k127_6544679_5 - - - - 0.000000000000000000000004943 110.0
TLS2_k127_6544983_0 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000006401 146.0
TLS2_k127_6544983_1 - - - - 0.000000000000000000000000001098 119.0
TLS2_k127_6544983_2 - - - - 0.00000009868 60.0
TLS2_k127_65465_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 1.387e-228 719.0
TLS2_k127_65465_1 Belongs to the KdsA family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 470.0
TLS2_k127_65465_2 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007085 340.0
TLS2_k127_65465_3 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006657 252.0
TLS2_k127_65465_4 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 0.0000000000000000000000000000000000000000000000000004901 184.0
TLS2_k127_65465_5 Thioredoxin K05838 - - 0.0000000000000000000000000000000000000000000000001102 182.0
TLS2_k127_65465_6 GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000005769 160.0
TLS2_k127_65465_7 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.00000000000000000000000000000000006051 145.0
TLS2_k127_65465_8 Domain of unknown function (DUF1330) - - - 0.000000000000000000002373 102.0
TLS2_k127_6565342_0 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 365.0
TLS2_k127_6565342_1 Belongs to the MtfA family K09933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 317.0
TLS2_k127_6574153_0 ATPase FliI YscN family K02412 - 3.6.3.14 1.125e-213 671.0
TLS2_k127_6574153_1 The M ring may be actively involved in energy transduction K02409 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 550.0
TLS2_k127_6574153_10 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.0000000000000000000000000000000002887 138.0
TLS2_k127_6574153_11 Flagellar hook-basal body K02408 - - 0.000000000000000000000000000006989 121.0
TLS2_k127_6574153_12 Flagellar hook-length control protein K02414 - - 0.000000000000000000002081 108.0
TLS2_k127_6574153_13 Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility - - - 0.0000000000000000001501 89.0
TLS2_k127_6574153_14 Flagellar biosynthesis protein, FliO K02418 - - 0.0000000000000000003739 93.0
TLS2_k127_6574153_2 flagellar motor switch protein K02410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 501.0
TLS2_k127_6574153_3 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007772 510.0
TLS2_k127_6574153_4 flagellar motor switch protein K02416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 491.0
TLS2_k127_6574153_5 His Kinase A (phosphoacceptor) domain K10942 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 380.0
TLS2_k127_6574153_6 Flagellar motor switch K02417 - - 0.000000000000000000000000000000000000000000000000000009131 192.0
TLS2_k127_6574153_7 Plays a role in the flagellum-specific transport system K02419 - - 0.0000000000000000000000000000000000000000000006088 173.0
TLS2_k127_6574153_8 COG1317 Flagellar biosynthesis type III secretory pathway protein K02411 - - 0.000000000000000000000000000000000000000000001634 172.0
TLS2_k127_6574153_9 Flagellar export protein FliJ K02413 - - 0.00000000000000000000000000000000000001247 149.0
TLS2_k127_6575803_0 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 0.0 1176.0
TLS2_k127_6575803_1 PFAM Glycoside hydrolase 15-related - - - 1.723e-317 978.0
TLS2_k127_6575803_2 Sodium/hydrogen exchanger family K03455 - - 2.393e-197 630.0
TLS2_k127_6575803_3 Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002046 279.0
TLS2_k127_6575803_4 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004249 297.0
TLS2_k127_6575803_5 Protein of unknown function (DUF3124) - - - 0.0000000000000000000000000003297 124.0
TLS2_k127_6575803_6 Belongs to the universal stress protein A family - - - 0.00000000000000000000005287 106.0
TLS2_k127_6584172_0 Transcriptional activator of acetoin glycerol metabolism K21405 - - 3.732e-282 878.0
TLS2_k127_6584172_1 Belongs to the SAICAR synthetase family K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004232 453.0
TLS2_k127_6584172_2 Phosphate-starvation-inducible E - - - 0.000000000000000000000000000000000000001284 152.0
TLS2_k127_6584172_3 Diguanylate cyclase - - - 0.00000001217 62.0
TLS2_k127_6585122_0 Sel1-like repeats. K07126 - - 0.0000000000000000000000000000000000000000000000000000000000000000006471 249.0
TLS2_k127_6585122_1 Heat shock protein DnaJ domain protein - - - 0.000002842 59.0
TLS2_k127_6617090_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 2.078e-246 764.0
TLS2_k127_6617090_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009588 464.0
TLS2_k127_6617090_10 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000000002696 118.0
TLS2_k127_6617090_11 Binds single-stranded DNA at the primosome assembly site (PAS) K02686 - - 0.00000000000000000001993 95.0
TLS2_k127_6617090_2 Belongs to the GST superfamily K03599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 403.0
TLS2_k127_6617090_3 Cytochrome C1 K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 358.0
TLS2_k127_6617090_4 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 321.0
TLS2_k127_6617090_5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 316.0
TLS2_k127_6617090_6 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008715 315.0
TLS2_k127_6617090_7 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000000000000000000000000000000000001915 206.0
TLS2_k127_6617090_8 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000000000000000000005464 179.0
TLS2_k127_6617090_9 stringent starvation protein B K03600 - - 0.00000000000000000000000000000000000000001049 157.0
TLS2_k127_6637336_0 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 451.0
TLS2_k127_6637336_1 Fe-S cluster K03616 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 425.0
TLS2_k127_6637336_2 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002749 274.0
TLS2_k127_6637336_3 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000004557 246.0
TLS2_k127_6637336_4 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000000000000000000000000000001302 189.0
TLS2_k127_6637336_5 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.00000000000000000000003926 100.0
TLS2_k127_6637336_6 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 - - 0.00000000000005757 77.0
TLS2_k127_6697250_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 9.87e-321 994.0
TLS2_k127_6697250_1 COG0643 Chemotaxis protein histidine kinase and related kinases K03407 - 2.7.13.3 2.683e-267 836.0
TLS2_k127_6697250_10 negative regulator of flagellin synthesis K02398 - - 0.0000000000000007201 79.0
TLS2_k127_6697250_2 Flagellar biosynthesis regulator FlhF K02404 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008293 473.0
TLS2_k127_6697250_3 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000313 409.0
TLS2_k127_6697250_4 flagellar motor K02556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007879 369.0
TLS2_k127_6697250_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 342.0
TLS2_k127_6697250_6 Flagellar motor protein K02557 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006834 299.0
TLS2_k127_6697250_7 Cellulose biosynthesis protein BcsQ K04562 - - 0.0000000000000000000000000000000000000001931 160.0
TLS2_k127_6697250_8 Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) K03414 - - 0.000000000000000000000000000000009879 129.0
TLS2_k127_6697250_9 FlgN protein K02399 - - 0.000000000000000001416 94.0
TLS2_k127_6698259_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 2333.0
TLS2_k127_6698259_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 2261.0
TLS2_k127_6698259_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1214.0
TLS2_k127_6698259_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001595 278.0
TLS2_k127_6698259_4 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000000007052 231.0
TLS2_k127_6698259_5 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000001203 151.0
TLS2_k127_6698259_6 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000001016 75.0
TLS2_k127_6751104_0 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K13819 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 453.0
TLS2_k127_6751104_1 Domains Cache_1, HAMP, PAS, PAS K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000716 307.0
TLS2_k127_6751104_2 V4R K07013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001398 264.0
TLS2_k127_6751104_3 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000003191 234.0
TLS2_k127_6751104_4 Protein of unknown function, DUF269 - - - 0.000000000000000000000000000000000000000000000001393 175.0
TLS2_k127_6751104_5 4Fe-4S double cluster binding domain - - - 0.00000000000000000000000000001303 120.0
TLS2_k127_6751104_6 Rop-like - - - 0.000000000000000000000000006536 115.0
TLS2_k127_6751104_7 - - - - 0.0000000000000000000000001641 111.0
TLS2_k127_675393_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 1.743e-221 694.0
TLS2_k127_675393_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 371.0
TLS2_k127_675393_2 dihydropteroate synthase K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007481 355.0
TLS2_k127_675393_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004376 340.0
TLS2_k127_675393_4 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 308.0
TLS2_k127_6758667_0 Protein of unknown function (DUF1631) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 334.0
TLS2_k127_6758667_1 TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 323.0
TLS2_k127_6758667_2 Belongs to the peptidase S11 family K01286,K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003854 272.0
TLS2_k127_6758667_3 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000002434 130.0
TLS2_k127_6758667_4 Protein of unknown function (DUF3617) - - - 0.0000000000000005724 89.0
TLS2_k127_6768409_0 Ammonium Transporter Family K03320,K06580 - - 3.769e-221 691.0
TLS2_k127_6768409_1 4-alpha-glucanotransferase K00705,K06044 - 2.4.1.25,5.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 492.0
TLS2_k127_6768409_2 Alkaline and neutral invertase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 430.0
TLS2_k127_6770646_0 phosphate starvation-inducible protein PhoH K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 482.0
TLS2_k127_6770646_1 Mg2 and Co2 transporter CorC K06189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008957 397.0
TLS2_k127_6770646_2 Carbon-nitrogen hydrolase K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005252 269.0
TLS2_k127_6770646_3 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000000000000000000000000000001972 191.0
TLS2_k127_6770646_4 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000001844 169.0
TLS2_k127_6773402_0 Part of a membrane complex involved in electron transport K03614 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 590.0
TLS2_k127_6773402_1 Part of a membrane complex involved in electron transport K03615 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001073 279.0
TLS2_k127_6773402_2 FMN_bind K03612 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002065 274.0
TLS2_k127_6773402_3 Part of a membrane complex involved in electron transport K03613 - - 0.00000000000000000000000000000000000000000009581 169.0
TLS2_k127_6807591_0 CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons K01026 - 2.8.3.1 2.238e-254 816.0
TLS2_k127_6807591_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 1.777e-247 768.0
TLS2_k127_6807591_10 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000000000000318 218.0
TLS2_k127_6807591_11 FAD-dependent pyridine - - - 0.00000000000000000000000000000000000000000206 158.0
TLS2_k127_6807591_12 Phasin protein - - - 0.0000000000000000000000000000000000004809 146.0
TLS2_k127_6807591_13 Mut7-C ubiquitin - - - 0.00000000000000000000000008366 111.0
TLS2_k127_6807591_2 ABC-type transport system, involved in lipoprotein release, permease component K02004 - - 7.196e-200 659.0
TLS2_k127_6807591_3 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 569.0
TLS2_k127_6807591_4 Bacterial extracellular solute-binding protein K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003299 432.0
TLS2_k127_6807591_5 Lipocalin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 386.0
TLS2_k127_6807591_6 Binding-protein-dependent transport system inner membrane component K05773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005463 310.0
TLS2_k127_6807591_7 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006097 274.0
TLS2_k127_6807591_8 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006221 258.0
TLS2_k127_6807591_9 Belongs to the ABC transporter superfamily K06857 - 3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000000000004121 254.0
TLS2_k127_685168_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 1.027e-231 723.0
TLS2_k127_685168_1 histidyl-tRNA synthetase K01892 - 6.1.1.21 5.635e-211 661.0
TLS2_k127_685168_10 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008052 409.0
TLS2_k127_685168_11 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 331.0
TLS2_k127_685168_12 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000000000000000000009328 250.0
TLS2_k127_685168_13 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000001243 233.0
TLS2_k127_685168_14 type 4 pilus biogenesis protein K02656 - - 0.0000000000000000000000000000000000000000000000000000000000216 219.0
TLS2_k127_685168_15 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000000000000000000000003687 149.0
TLS2_k127_685168_16 Domain of unknown function (DUF4115) K15539 - - 0.00000000000000000000000000000000000003598 154.0
TLS2_k127_685168_17 protein conserved in bacteria K09937 - - 0.000000000000000003167 90.0
TLS2_k127_685168_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 6.593e-199 626.0
TLS2_k127_685168_3 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 3.769e-198 625.0
TLS2_k127_685168_4 TRAP C4-dicarboxylate transport system permease DctM subunit K11690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 595.0
TLS2_k127_685168_5 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004753 578.0
TLS2_k127_685168_6 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002811 567.0
TLS2_k127_685168_7 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 519.0
TLS2_k127_685168_8 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 494.0
TLS2_k127_685168_9 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 466.0
TLS2_k127_685516_0 Alanine dehydrogenase/PNT, N-terminal domain K00324 - 1.6.1.2 1.909e-273 849.0
TLS2_k127_685516_1 Asparagine synthase K01953 - 6.3.5.4 2.551e-266 831.0
TLS2_k127_685516_2 glycolate oxidase iron-sulfur subunit K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 574.0
TLS2_k127_685516_3 phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 299.0
TLS2_k127_685516_4 RDD family - - - 0.0000000000000000000000000000000000000000000000000000000002395 210.0
TLS2_k127_685516_5 deaminase zinc-binding - - - 0.00000000000000000000000000000000000000000000000000000837 203.0
TLS2_k127_685516_6 Protein of unknown function (DUF1304) K08987 - - 0.00000000000000000000001711 100.0
TLS2_k127_685516_7 - - - - 0.000000000000001184 81.0
TLS2_k127_685516_8 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000001277 61.0
TLS2_k127_6860078_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 490.0
TLS2_k127_6860078_1 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003758 449.0
TLS2_k127_6860078_2 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 445.0
TLS2_k127_6860078_3 cytochrome - - - 0.00000000000000000000000000000000000000000000000000000009201 198.0
TLS2_k127_6860078_4 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000007337 159.0
TLS2_k127_6883931_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 7.076e-217 677.0
TLS2_k127_6883931_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008356 537.0
TLS2_k127_6883931_2 Periplasmic binding protein K02016,K06858 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 394.0
TLS2_k127_6883931_3 Phasin protein - - - 0.0000000000000000000000000000000000000000000000000000001783 201.0
TLS2_k127_6901531_0 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 455.0
TLS2_k127_6901531_1 Methyltransferase - - - 0.0000000000000000000000000000000002553 139.0
TLS2_k127_6930966_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K05922 - 1.12.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 595.0
TLS2_k127_6930966_1 NiFe/NiFeSe hydrogenase small subunit C-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007635 458.0
TLS2_k127_6930966_2 PFAM Cysteine-rich - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000392 424.0
TLS2_k127_6930966_3 nitrate reductase activity - - - 0.00000000000000000000000000000000000000000000000000000000009668 214.0
TLS2_k127_6941610_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1492.0
TLS2_k127_6941610_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006439 450.0
TLS2_k127_6941610_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000000000000000000000000000000000000000000000000000000005289 218.0
TLS2_k127_6941610_3 Bacterial transcriptional repressor C-terminal - - - 0.000000000000000000000000000000000000000000000009058 178.0
TLS2_k127_6941610_4 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.0000000000000000001033 93.0
TLS2_k127_6949964_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 1.618e-229 711.0
TLS2_k127_6949964_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 330.0
TLS2_k127_6949964_2 Nitrate reductase delta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 319.0
TLS2_k127_6949964_3 Domain of unknown function (DUF309) - - - 0.000000000000000000000000000000000000000000000000000000000000000001865 236.0
TLS2_k127_6949964_4 Histidine biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000006827 214.0
TLS2_k127_6960780_0 AAA domain K07028 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 397.0
TLS2_k127_6960780_1 Domain of unknown function (DUF4398) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000833 301.0
TLS2_k127_6960780_2 Domain of unknown function (DUF4398) - - - 0.0000000000000000000000000000005833 127.0
TLS2_k127_70103_0 MASE1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 302.0
TLS2_k127_70103_1 COG1863 Multisubunit Na H antiporter MnhE subunit K05569 - - 0.0000000000000000000000000000000000000000000000000000000000000003366 223.0
TLS2_k127_70103_2 monovalent cation:proton antiporter activity K05571 - - 0.0000000000000000000000000000003652 130.0
TLS2_k127_70103_3 Multiple resistance and pH regulation protein F K05570 - - 0.00000000000000000000000002116 121.0
TLS2_k127_70103_4 Domain of unknown function (DUF4040) K05566 - - 0.0000000000007072 76.0
TLS2_k127_7022843_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 6.943e-260 818.0
TLS2_k127_7022843_1 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.0000000000000000000000000000000000000000000000000000001568 209.0
TLS2_k127_7025070_0 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 571.0
TLS2_k127_7025070_1 amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 517.0
TLS2_k127_7025070_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007612 523.0
TLS2_k127_7025070_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 477.0
TLS2_k127_7025070_4 branched-chain amino acid K01995 - - 0.00000000000000000000000000000000000000000000000000005479 205.0
TLS2_k127_7025070_5 Cytochrome c K08738 - - 0.0000000000000000000000000002137 118.0
TLS2_k127_7025814_0 Malic enzyme K00029 - 1.1.1.40 2.47e-204 654.0
TLS2_k127_7025814_1 Cobyrinic acid ac-diamide synthase K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002067 285.0
TLS2_k127_7052937_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 1.258e-208 663.0
TLS2_k127_7052937_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 5.725e-202 645.0
TLS2_k127_7106793_0 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 8.466e-245 763.0
TLS2_k127_7106793_1 homoserine dehydrogenase K00003 - 1.1.1.3 3.024e-236 736.0
TLS2_k127_7106793_2 Aminotransferase K14260 - 2.6.1.2,2.6.1.66 1.177e-227 709.0
TLS2_k127_7106793_3 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 604.0
TLS2_k127_7106793_4 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004188 329.0
TLS2_k127_7106793_5 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002473 257.0
TLS2_k127_7106793_6 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000001183 214.0
TLS2_k127_7106793_7 Tellurite resistance protein TerB - - - 0.0000000000000000000000000000000000000000000000000000006626 199.0
TLS2_k127_7106793_8 Protein of unknown function (DUF3014) - - - 0.0000000000000000000000000000000000000000000003296 170.0
TLS2_k127_711277_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 448.0
TLS2_k127_711277_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 347.0
TLS2_k127_71141_0 Cyclic nucleotide-monophosphate binding domain K01420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006163 296.0
TLS2_k127_71141_1 Cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000002147 204.0
TLS2_k127_71141_2 5,10-methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000002885 81.0
TLS2_k127_71331_0 Carbamoyltransferase C-terminus K00612 - - 0.0 1087.0
TLS2_k127_71331_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001359 255.0
TLS2_k127_71331_2 Two-component sensor kinase N-terminal K07645 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000002297 241.0
TLS2_k127_71331_3 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000002585 201.0
TLS2_k127_71331_4 Methyltransferase domain - - - 0.00000000000000000000000000000000003886 147.0
TLS2_k127_71331_5 Glycosyltransferase family 9 (heptosyltransferase) K02841 - - 0.0000000000003898 74.0
TLS2_k127_7180467_0 signal transduction protein containing EAL and modified HD-GYP domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006372 417.0
TLS2_k127_7180467_1 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 308.0
TLS2_k127_7180467_2 branched-chain amino acid K01995 - - 0.000000000000000000000000000000000000000000000000000000000000006777 218.0
TLS2_k127_7197048_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000963 349.0
TLS2_k127_7197048_1 PFAM short-chain dehydrogenase reductase SDR K00034,K00059 - 1.1.1.100,1.1.1.47 0.00000000000000000000000000000008739 127.0
TLS2_k127_7207148_0 DNA segregation ATPase FtsK SpoIIIE K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007826 554.0
TLS2_k127_7207148_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 497.0
TLS2_k127_7221147_0 Cysteine-rich domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 547.0
TLS2_k127_7221147_1 Nitrate reductase gamma subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 332.0
TLS2_k127_7221147_2 DsrC like protein K11179 - - 0.0000000000000000000000000000000000000000000000000000001312 196.0
TLS2_k127_7221147_3 DsrH like protein K07237 - - 0.0000000000000000000000000005395 114.0
TLS2_k127_7232042_0 RNA polymerase sigma K03087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005886 372.0
TLS2_k127_7232042_1 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007766 367.0
TLS2_k127_7232042_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008438 296.0
TLS2_k127_7232042_3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007572 269.0
TLS2_k127_7232042_4 COG0739 Membrane proteins related to metalloendopeptidases K06194 - - 0.0000000000000000000000000000000000000000000000000000000002037 216.0
TLS2_k127_7232042_5 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.000000000000000000000000000000000000000000000000003293 186.0
TLS2_k127_7232042_6 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000001796 148.0
TLS2_k127_7307745_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 1.33e-322 1004.0
TLS2_k127_7307745_1 Belongs to the glycosyl hydrolase 57 family K22451 - 2.4.1.25 1.532e-251 801.0
TLS2_k127_7307745_2 Glycosyl hydrolase family 57 - - - 8.419e-218 688.0
TLS2_k127_73372_0 Periplasmic copper-binding protein (NosD) K07218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 370.0
TLS2_k127_73372_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 332.0
TLS2_k127_7387182_0 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004135 431.0
TLS2_k127_7387182_1 Na H antiporter, MnhB K05566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003778 261.0
TLS2_k127_7387182_2 Multisubunit Na H antiporter MnhC subunit K05567 - - 0.0000000000000000000000000000000000000007712 159.0
TLS2_k127_7398689_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009467 246.0
TLS2_k127_7398689_1 Cysteine-rich secretory protein family - - - 0.00000000000000000000000000000000000000005963 165.0
TLS2_k127_7398689_2 Phosphate-starvation-inducible E - - - 0.000000000000000000000000002842 113.0
TLS2_k127_7398689_3 Nuclear protein SET K07117 - - 0.000000000000000000000009019 107.0
TLS2_k127_7398689_4 RNA-binding protein K14761 - - 0.000000000000000002533 86.0
TLS2_k127_7398689_5 DSBA Oxidoreductase - - - 0.00000397 49.0
TLS2_k127_7445813_0 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 440.0
TLS2_k127_7445813_1 diguanylate cyclase K13590 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 313.0
TLS2_k127_7445813_2 COG2346, Truncated hemoglobins - - - 0.0000000000000000000000000000000159 133.0
TLS2_k127_7445813_3 - - - - 0.000000000000000000003545 98.0
TLS2_k127_7445813_4 Putative prokaryotic signal transducing protein - - - 0.0000000000000007556 85.0
TLS2_k127_7445813_5 - - - - 0.0000000000004545 73.0
TLS2_k127_799082_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 443.0
TLS2_k127_799082_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 411.0
TLS2_k127_799082_2 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.000000000000000000000000000000000000000000000000292 177.0
TLS2_k127_799082_3 AMP-binding enzyme - - - 0.0000000000000000000000000000000000004646 142.0
TLS2_k127_799082_4 Acyl carrier protein - - - 0.0000000000000000124 90.0
TLS2_k127_79938_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 - - 1.6e-297 922.0
TLS2_k127_79938_1 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 1.519e-243 805.0
TLS2_k127_79938_10 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.000000000000000000000000000000000000000000000000000000000002899 229.0
TLS2_k127_79938_11 methyltransferase - - - 0.000000000000000000000000000000000001843 151.0
TLS2_k127_79938_2 Amp-dependent synthetase and ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 600.0
TLS2_k127_79938_3 Two-component sensor kinase N-terminal K07645 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 490.0
TLS2_k127_79938_4 response regulator K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 356.0
TLS2_k127_79938_5 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007863 347.0
TLS2_k127_79938_6 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 342.0
TLS2_k127_79938_7 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002377 275.0
TLS2_k127_79938_8 Thermostable hemolysin - - - 0.0000000000000000000000000000000000000000000000000000000000000000001856 235.0
TLS2_k127_79938_9 Long-chain fatty acid--CoA ligase - - - 0.000000000000000000000000000000000000000000000000000000000000001832 231.0
TLS2_k127_803173_0 Secretin N-terminal domain K02453,K12282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000825 501.0
TLS2_k127_803173_1 Pilus assembly protein K12279 - - 0.0000000000000000000000000000000000000006847 154.0
TLS2_k127_803173_2 Type II secretion system (T2SS), protein M K12280 - - 0.0000000000000000000000000000000000000008114 156.0
TLS2_k127_803173_3 PFAM Fimbrial assembly family protein - - - 0.0000000000000000000000000000001328 135.0
TLS2_k127_803173_4 - K12281 - - 0.000000002868 68.0
TLS2_k127_80834_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005318 598.0
TLS2_k127_80834_1 glutamine synthetase K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 545.0
TLS2_k127_80834_10 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000000005909 177.0
TLS2_k127_80834_2 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 529.0
TLS2_k127_80834_3 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 437.0
TLS2_k127_80834_4 Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 389.0
TLS2_k127_80834_5 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006424 395.0
TLS2_k127_80834_6 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 382.0
TLS2_k127_80834_7 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009016 294.0
TLS2_k127_80834_8 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001427 254.0
TLS2_k127_80834_9 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001054 255.0
TLS2_k127_818609_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 8.234e-232 727.0
TLS2_k127_818609_1 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 350.0
TLS2_k127_818609_2 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 338.0
TLS2_k127_818609_3 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 332.0
TLS2_k127_818609_4 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 296.0
TLS2_k127_83100_0 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000000000000000004375 218.0
TLS2_k127_83100_1 - - - - 0.00000000000000000000000000000000000000000002546 169.0
TLS2_k127_83100_2 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.0000000000000000000000000000006968 123.0
TLS2_k127_83100_3 Domain of unknown function (DUF4124) - - - 0.00003309 55.0
TLS2_k127_865362_0 pyruvate phosphate dikinase K01006,K01007 - 2.7.9.1,2.7.9.2 0.0 1196.0
TLS2_k127_865362_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.978e-305 940.0
TLS2_k127_865362_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.221e-254 791.0
TLS2_k127_865362_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000000000001895 177.0
TLS2_k127_889620_0 PFAM Prokaryotic protein of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003657 552.0
TLS2_k127_889620_1 Zn-dependent dipeptidase, microsomal dipeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 411.0
TLS2_k127_889620_2 HpcH/HpaI aldolase/citrate lyase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 368.0
TLS2_k127_889620_3 NADPH-quinone reductase (modulator of drug activity B) K00355 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009493 284.0
TLS2_k127_889620_4 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0001846 44.0
TLS2_k127_89413_0 nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC K02567 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 326.0
TLS2_k127_89413_1 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000002836 143.0
TLS2_k127_89413_2 Belongs to the heme-copper respiratory oxidase family - - - 0.000000000000000000000000000000007247 133.0
TLS2_k127_89413_3 conserved protein (DUF2249) - - - 0.0000000000466 65.0
TLS2_k127_89413_4 negative regulation of establishment of protein localization K02570 - - 0.00003164 55.0
TLS2_k127_935415_0 His Kinase A (phospho-acceptor) domain - - - 0.0 1236.0
TLS2_k127_935415_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1216.0
TLS2_k127_935415_10 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 312.0
TLS2_k127_935415_11 ferredoxin--nadp reductase K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 300.0
TLS2_k127_935415_12 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001182 261.0
TLS2_k127_935415_13 UPF0114 protein - - - 0.000000000000000000000000000000000000000000000000000000000002529 237.0
TLS2_k127_935415_14 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000000000008947 210.0
TLS2_k127_935415_15 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000000000000008539 208.0
TLS2_k127_935415_16 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000002089 204.0
TLS2_k127_935415_17 - - - - 0.000000000000000000000000000000000139 142.0
TLS2_k127_935415_18 DsrC like protein K11179 - - 0.0000000000000000000000000002434 118.0
TLS2_k127_935415_19 - - - - 0.0000000000000000000006293 106.0
TLS2_k127_935415_2 DNA polymerase III K02342 - 2.7.7.7 3.135e-314 977.0
TLS2_k127_935415_20 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain - - - 0.00000000000000000005995 102.0
TLS2_k127_935415_3 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 3.224e-299 926.0
TLS2_k127_935415_4 Diguanylate cyclase - - - 2.451e-230 749.0
TLS2_k127_935415_5 Putative nucleotidyltransferase substrate binding domain K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009618 501.0
TLS2_k127_935415_6 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 471.0
TLS2_k127_935415_7 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 420.0
TLS2_k127_935415_8 RecB family exonuclease K01144 - 3.1.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 356.0
TLS2_k127_935415_9 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 340.0
TLS2_k127_946948_0 3-oxoacyl- acyl-carrier-protein K16872 - 2.3.1.207 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 598.0
TLS2_k127_946948_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K03472 - 1.2.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003834 489.0
TLS2_k127_946948_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 444.0
TLS2_k127_946948_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000007499 237.0
TLS2_k127_946948_4 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000007283 143.0
TLS2_k127_946948_5 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.0000000000000000000000000000002035 130.0
TLS2_k127_946948_6 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.0000000000000000003652 91.0
TLS2_k127_946948_7 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.0000001054 55.0
TLS2_k127_950750_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1048.0
TLS2_k127_950750_1 Domain of unknown function DUF21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 537.0
TLS2_k127_950750_2 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004482 516.0
TLS2_k127_950750_3 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006992 392.0
TLS2_k127_950750_4 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 386.0
TLS2_k127_950750_5 Polysaccharide pyruvyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004331 309.0
TLS2_k127_950750_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003186 283.0
TLS2_k127_950750_7 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006119 265.0
TLS2_k127_950750_8 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000001885 271.0
TLS2_k127_950750_9 PFAM aldo keto reductase - - - 0.0000000000000000000002592 104.0
TLS2_k127_960419_0 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 380.0
TLS2_k127_960419_1 diguanylate cyclase K13590 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 317.0
TLS2_k127_960419_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 301.0
TLS2_k127_960419_3 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 307.0
TLS2_k127_960419_4 PFAM cytochrome B561 K12262 - - 0.000000000000000005134 92.0
TLS2_k127_960419_5 - - - - 0.00000000000001166 78.0
TLS2_k127_961125_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 526.0
TLS2_k127_961125_1 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 346.0
TLS2_k127_961125_2 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005843 331.0
TLS2_k127_961125_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000004829 254.0
TLS2_k127_961125_4 coa-binding K06929 - - 0.00000000000000000000000000000000000000000000000002218 182.0
TLS2_k127_972807_0 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000533 525.0
TLS2_k127_972807_1 Belongs to the peptidase S1C family K04691,K04772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000752 514.0
TLS2_k127_972807_10 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003791 273.0
TLS2_k127_972807_11 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000348 241.0
TLS2_k127_972807_12 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000000000000000000000003344 233.0
TLS2_k127_972807_13 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 - - 0.000000000000000000000000000000000000000000003402 168.0
TLS2_k127_972807_14 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.000000000000000000000000000000000000000000003744 168.0
TLS2_k127_972807_15 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.000000000000000000000000000000001165 134.0
TLS2_k127_972807_16 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000000000000003374 106.0
TLS2_k127_972807_2 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 502.0
TLS2_k127_972807_3 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 441.0
TLS2_k127_972807_4 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004562 436.0
TLS2_k127_972807_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 437.0
TLS2_k127_972807_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 374.0
TLS2_k127_972807_7 NIF3 (NGG1p interacting factor 3) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 341.0
TLS2_k127_972807_8 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 318.0
TLS2_k127_972807_9 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 305.0
TLS2_k127_974225_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009408 476.0
TLS2_k127_974225_1 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003799 276.0
TLS2_k127_974225_2 Belongs to the CarB family K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001922 270.0
TLS2_k127_974225_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001984 256.0
TLS2_k127_974225_4 RNA-binding protein containing KH domain possibly ribosomal protein - - - 0.00000000000000000000000000000000000005338 145.0
TLS2_k127_974266_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 - - 3.219e-194 612.0
TLS2_k127_974266_1 PFAM TatD-related deoxyribonuclease K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007579 312.0
TLS2_k127_974266_2 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005667 248.0
TLS2_k127_974266_3 Ferredoxin, 2Fe-2S type, ISC system K04755 - - 0.000000000000000000000000000000000000000000000000000001802 194.0
TLS2_k127_974266_4 PFAM Ankyrin K10799 - 2.4.2.30 0.000000000000000000000000000000000000000000000000000002341 203.0
TLS2_k127_974266_5 FeS assembly protein IscX - - - 0.000000000000000000000000000004134 126.0
TLS2_k127_981146_0 Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 485.0
TLS2_k127_981146_1 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002172 260.0
TLS2_k127_981146_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000003493 246.0
TLS2_k127_981146_3 PFAM phosphoesterase PA-phosphatase related K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000004604 177.0
TLS2_k127_98208_0 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000001952 192.0
TLS2_k127_98208_1 sulfur oxidation protein SoxY K17226 - - 0.0000000000000000000000000000000000000000001742 162.0
TLS2_k127_98208_2 AntiSigma factor - - - 0.00000000000000000000000000000000003888 146.0
TLS2_k127_98208_3 Sulphur oxidation protein SoxZ K17227 - - 0.00000000000000000000000000000004641 134.0
TLS2_k127_98208_4 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.00000007699 56.0
TLS2_k127_986140_0 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide - - - 6.833e-205 651.0
TLS2_k127_986140_1 Necessary for formate dehydrogenase activity K02380 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 289.0
TLS2_k127_986140_2 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000000000000000000000002988 158.0
TLS2_k127_986140_3 PFAM Hemerythrin HHE cation binding domain K07216 - - 0.0000000000000000000000000000000000001854 145.0
TLS2_k127_986140_4 CcdB protein K19163 - - 0.0000000000000000000000000000000000005814 142.0
TLS2_k127_986140_5 Prokaryotic cytochrome b561 K00127 - - 0.000000000000000000002206 93.0
TLS2_k127_986140_6 Post-segregation antitoxin CcdA K19164 - - 0.0000000000000000006304 89.0
TLS2_k127_988202_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.0 1032.0
TLS2_k127_988202_1 Belongs to the glycosyl hydrolase 57 family K22451 - 2.4.1.25 0.000000000000000000000000000000000006184 143.0