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Overview

ID MAG04006
Name TLS2_bin.43
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Chloroflexota
Class Anaerolineae
Order Promineifilales
Family Promineifilaceae
Genus CAADGU01
Species
Assembly information
Completeness (%) 83.11
Contamination (%) 2.9
GC content (%) 57.0
N50 (bp) 7,105
Genome size (bp) 4,938,849

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes4091

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1008648_0 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004191 407.0
TLS2_k127_1008648_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0003343 52.0
TLS2_k127_1011568_0 NADH flavin oxidoreductase NADH oxidase K09461 - 1.14.13.40 4.256e-295 925.0
TLS2_k127_1011568_1 4-hydroxybenzoate 3-monooxygenase K00481 - 1.14.13.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005874 511.0
TLS2_k127_1011568_2 Adenylosuccinate lyase C-terminus K01857 - 5.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 447.0
TLS2_k127_1011654_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 538.0
TLS2_k127_1011654_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 484.0
TLS2_k127_1011654_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 433.0
TLS2_k127_1011654_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 297.0
TLS2_k127_1011654_4 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000005961 180.0
TLS2_k127_1011654_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000000000002892 175.0
TLS2_k127_1016545_0 choline dehydrogenase activity K03333 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114 1.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 595.0
TLS2_k127_1016545_1 Cellulose biosynthesis protein BcsQ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000516 223.0
TLS2_k127_1016545_2 XRE family transcriptional regulator K07667 - - 0.00000000000000000000000000000000000000000000000000004308 195.0
TLS2_k127_1016545_3 Belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.0000000000000000000000000000000000000000000000000005813 193.0
TLS2_k127_1016545_4 Belongs to the ParB family K03497 - - 0.00000000000000000000000003217 123.0
TLS2_k127_1028116_0 helicase superfamily c-terminal domain K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 453.0
TLS2_k127_1029181_0 B12 binding domain K00548 - 2.1.1.13 0.0 1560.0
TLS2_k127_1029181_1 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000001294 204.0
TLS2_k127_1029181_2 PIN domain - - - 0.0000000000000000000000000000000000000000000000000000008662 194.0
TLS2_k127_1029181_3 - - - - 0.0000000000000000000000000000007243 126.0
TLS2_k127_1029181_4 SpoVT / AbrB like domain - - - 0.00000000000000000000009695 100.0
TLS2_k127_1029181_5 PFAM Sporulation and spore germination - - - 0.00000005879 62.0
TLS2_k127_1034901_0 PFAM PIN domain - - - 0.00000000000000000000000000000000000002192 148.0
TLS2_k127_1034901_1 DNA-templated transcription, initiation K03088 - - 0.00000000000000000002891 100.0
TLS2_k127_1034901_2 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000000000003178 93.0
TLS2_k127_1034901_3 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000000000004065 87.0
TLS2_k127_1034901_4 FecR protein - - - 0.0000000000000006774 91.0
TLS2_k127_1034901_5 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.000000006444 66.0
TLS2_k127_103630_0 Glycosyl transferase family group 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 313.0
TLS2_k127_103630_1 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001929 287.0
TLS2_k127_103630_2 TatD related DNase K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000003332 246.0
TLS2_k127_103630_3 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000001132 231.0
TLS2_k127_103630_4 - - - - 0.000000000000000000000000000000000000000000000000000005655 203.0
TLS2_k127_103630_5 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01840 - 5.4.2.8 0.0000000000000000000000000001252 116.0
TLS2_k127_103630_6 - - - - 0.0000000004698 64.0
TLS2_k127_103630_7 protein serine/threonine phosphatase activity - - - 0.000008028 59.0
TLS2_k127_1037170_0 heme binding K21472 - - 0.000000000000000000000000000000000000000000000000000000000001335 218.0
TLS2_k127_1037170_1 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000001727 156.0
TLS2_k127_104685_0 MacB-like periplasmic core domain K02004 - - 3.672e-274 868.0
TLS2_k127_104685_1 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 460.0
TLS2_k127_104685_2 ATPases associated with a variety of cellular activities K02003,K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008417 307.0
TLS2_k127_104685_3 - - - - 0.000000000000000000000000000000000000002881 154.0
TLS2_k127_104685_4 Copper resistance protein CopC K14166 - - 0.000000000000000000000000000002355 138.0
TLS2_k127_1048712_0 Pyridoxal-phosphate dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 324.0
TLS2_k127_1048712_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000005167 200.0
TLS2_k127_1048712_2 PFAM Formylglycine-generating sulfatase enzyme K18912 - 1.14.99.50 0.0000000000000000000000000000000000000000006381 177.0
TLS2_k127_1048712_3 PFAM extracellular solute-binding protein, family 3 K02030 - - 0.000000000000000000000000000000000001499 160.0
TLS2_k127_1048712_4 Response regulator, receiver K02030,K03407,K07679,K11443,K13924 - 2.1.1.80,2.7.13.3,3.1.1.61 0.0000000000000000000000000000002052 126.0
TLS2_k127_1048712_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000001912 93.0
TLS2_k127_1048712_6 tetraacyldisaccharide 4'-kinase activity K09791 - - 0.0000000000000000005242 89.0
TLS2_k127_1048712_7 Ig-like domain from next to BRCA1 gene K17987 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005770,GO:0005773,GO:0005829,GO:0006914,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0012505,GO:0016043,GO:0016236,GO:0022607,GO:0031410,GO:0031982,GO:0032182,GO:0034622,GO:0043130,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0051258,GO:0051259,GO:0061919,GO:0065003,GO:0071840,GO:0097708 - 0.00000000008536 76.0
TLS2_k127_1079371_0 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 366.0
TLS2_k127_1079371_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000001719 153.0
TLS2_k127_1085437_0 PFAM TrkA-N domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 328.0
TLS2_k127_1085437_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000159 279.0
TLS2_k127_1085437_2 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000001822 265.0
TLS2_k127_1085437_3 Protein of unknown function (DUF2723) - - - 0.00000000000000000000000000000000004072 156.0
TLS2_k127_1085437_5 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000794 89.0
TLS2_k127_1088981_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.973e-238 750.0
TLS2_k127_1088981_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 5.815e-216 686.0
TLS2_k127_1088981_2 Subtilase family K17734 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003958 288.0
TLS2_k127_1088981_3 PFAM sigma-70 region 2 domain protein K03088 - - 0.000000000000000000000000000000000000000000000000006485 190.0
TLS2_k127_1088981_4 Signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000003732 182.0
TLS2_k127_1088981_5 PIN domain - - - 0.000000000000000000000000001262 116.0
TLS2_k127_1088981_6 Polymer-forming cytoskeletal - - - 0.0000000000000005355 90.0
TLS2_k127_1088981_7 Ribbon-helix-helix protein, copG family - - - 0.000002063 53.0
TLS2_k127_1088981_8 transmembrane transcriptional regulator (anti-sigma factor) - - - 0.0001693 51.0
TLS2_k127_1093974_0 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 509.0
TLS2_k127_1093974_1 TIGRFAM mannose-6-phosphate isomerase, class I K01809 - 5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000005656 269.0
TLS2_k127_1093974_2 Protein of unknown function (DUF1349) K09702 - - 0.000000000000000000000000000000000000000000000000000007929 197.0
TLS2_k127_1093974_3 Lactoylglutathione lyase and related lyases - - - 0.000003222 49.0
TLS2_k127_1100683_0 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007944 433.0
TLS2_k127_1100683_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 386.0
TLS2_k127_1100915_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009376 280.0
TLS2_k127_1100915_1 stress protein (general stress protein 26) - - - 0.000000000000000000000000000000000000000000000000000000000000000000004904 237.0
TLS2_k127_1100915_2 Dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000002952 224.0
TLS2_k127_1100915_3 TIGRFAM integral membrane protein TIGR01906 - - - 0.0000000000000000000000000002225 124.0
TLS2_k127_1100915_4 Spermine/spermidine synthase domain - - - 0.00000000000000005728 85.0
TLS2_k127_1115957_0 Amidohydrolase family K06015 - 3.5.1.81 1.903e-208 660.0
TLS2_k127_1115957_1 ABC transporter, ATP-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 528.0
TLS2_k127_1115957_2 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000738 240.0
TLS2_k127_1115957_3 Belongs to the PEP-utilizing enzyme family K01007 - 2.7.9.2 0.000000000000000000000000000000000000001237 154.0
TLS2_k127_1115957_4 abc transporter atp-binding protein - - - 0.00000000000000000001156 98.0
TLS2_k127_1120198_0 Carbamoyl-phosphate synthetase large chain domain protein K01955 - 6.3.5.5 0.0 1435.0
TLS2_k127_1120198_1 TIGRFAM carbamoyl-phosphate synthase, small subunit K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008095 535.0
TLS2_k127_1120198_2 IMP dehydrogenase activity K04767 - - 0.0000000000000000000000000000000000001084 147.0
TLS2_k127_1120198_3 Protein of unknown function (DUF3788) - - - 0.00000000000000000000000000000000000969 140.0
TLS2_k127_1120198_4 - - - - 0.000000006668 57.0
TLS2_k127_1120198_5 Protein of unknown function (DUF2283) - - - 0.000006007 51.0
TLS2_k127_1134395_0 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008135 252.0
TLS2_k127_1134395_1 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000008262 222.0
TLS2_k127_1134395_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000004239 206.0
TLS2_k127_1134395_3 Type IV pilus biogenesis stability protein PilW - - - 0.000000000000007428 85.0
TLS2_k127_1135511_0 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005736 243.0
TLS2_k127_1135511_1 PFAM Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000004587 199.0
TLS2_k127_1135511_2 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000000000000000000000000000000002182 184.0
TLS2_k127_1135511_3 Histidine kinase K07675 - 2.7.13.3 0.00000000000000000000000000000000000000000005584 168.0
TLS2_k127_1144377_0 YceI-like domain - - - 0.000000000000000000000000000000000000000000000000000000000007206 216.0
TLS2_k127_1144377_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000002618 78.0
TLS2_k127_1144377_2 Domain of unknown function (DUF4872) - - - 0.000002364 55.0
TLS2_k127_1151732_0 WD domain, G-beta repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 426.0
TLS2_k127_1151732_1 CHAT domain - - - 0.00000000000002643 80.0
TLS2_k127_1151732_2 WD domain, G-beta repeat - - - 0.00000005367 66.0
TLS2_k127_115266_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 5e-324 1022.0
TLS2_k127_115266_1 protein-containing complex disassembly K02837,K07133 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 355.0
TLS2_k127_115266_2 TIGRFAM polyphosphate nucleotide phosphotransferase, PPK2 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007239 323.0
TLS2_k127_115266_3 protein possibly involved in aromatic compounds catabolism - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000007167 181.0
TLS2_k127_1157084_0 FAD dependent oxidoreductase K00301 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 530.0
TLS2_k127_1157084_1 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002171 283.0
TLS2_k127_1157084_2 glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000000001913 240.0
TLS2_k127_1157084_3 Putative RNA methylase family UPF0020 - - - 0.000000000000000000000000000000000000000000007279 176.0
TLS2_k127_1162098_0 cyclic 2,3-diphosphoglycerate synthetase activity - - - 4.626e-194 614.0
TLS2_k127_1162098_1 serine-type aminopeptidase activity K14475 - - 0.000000000000000000000001186 119.0
TLS2_k127_1162098_2 Ig-like domain from next to BRCA1 gene - - - 0.0000000000000000000003682 111.0
TLS2_k127_1162098_3 helix_turn_helix, mercury resistance - - - 0.0000000000001123 74.0
TLS2_k127_1165799_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009844 503.0
TLS2_k127_1165799_1 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 446.0
TLS2_k127_1165799_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009311 345.0
TLS2_k127_1165799_3 Belongs to the ATP-dependent AMP-binding enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 312.0
TLS2_k127_1166491_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 5.089e-223 702.0
TLS2_k127_1166491_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007726 321.0
TLS2_k127_1166491_2 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 294.0
TLS2_k127_1166491_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000002011 102.0
TLS2_k127_1166491_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000936 101.0
TLS2_k127_1166491_5 Domain of unknown function (DUF4342) - - - 0.000007434 53.0
TLS2_k127_1173303_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000001162 197.0
TLS2_k127_1173303_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000002311 177.0
TLS2_k127_1173303_2 Tetratricopeptide repeat protein - - - 0.000000000000000000000000000006763 134.0
TLS2_k127_1173303_3 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000001525 71.0
TLS2_k127_1173303_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000116 67.0
TLS2_k127_1185350_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1155.0
TLS2_k127_1185350_1 Peptidase M50 K16922 - - 0.0000000000000000000000000000000000000009207 156.0
TLS2_k127_1188372_0 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000007353 227.0
TLS2_k127_1188372_1 Tetratricopeptide repeats - - - 0.00000000000000000000000000009373 134.0
TLS2_k127_1214160_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1078.0
TLS2_k127_1214160_1 4Fe-4S ferredoxin K00124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009541 309.0
TLS2_k127_1214160_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005968 308.0
TLS2_k127_1214160_3 Protein of unknown function (DUF1428) - - - 0.00000000000000000000000000000000000000000000000000000000000000004383 225.0
TLS2_k127_1214160_4 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000001852 227.0
TLS2_k127_1214160_5 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000004447 205.0
TLS2_k127_1214160_6 CHAT domain - - - 0.00000000000000000000000000000000000000008015 153.0
TLS2_k127_1214160_7 Protein involved in formate dehydrogenase formation K02380 - - 0.0000000000000000000000000000000000001407 154.0
TLS2_k127_1214160_8 Phage integrase, N-terminal SAM-like domain - - - 0.000000000000000007103 85.0
TLS2_k127_122208_0 Methyltransferase type 11 K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004097 275.0
TLS2_k127_122208_1 Ntpase (Nacht family) K12132 - 2.7.11.1 0.000000000000000000000000000000000000000001855 173.0
TLS2_k127_122208_2 DNA-binding transcription factor activity K03892 - - 0.000000000000000000000001268 106.0
TLS2_k127_122208_3 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0002103 45.0
TLS2_k127_1231596_0 lyase activity K01667 - 4.1.99.1 2.467e-224 702.0
TLS2_k127_1231596_1 COG0714 MoxR-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009899 345.0
TLS2_k127_1231596_2 PFAM short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009526 268.0
TLS2_k127_1231596_3 Probable molybdopterin binding domain K07141 - 2.7.7.76 0.000000000000000000000000000000000000000000000000004526 190.0
TLS2_k127_1231596_5 Acetyltransferase (GNAT) domain - - - 0.0003446 53.0
TLS2_k127_1254174_0 domain, Protein K13874,K22217 - 3.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 589.0
TLS2_k127_1254174_1 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 296.0
TLS2_k127_1254174_2 histidine kinase A domain protein K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001052 280.0
TLS2_k127_1254174_3 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000000000000000000000002873 251.0
TLS2_k127_1254174_4 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000003737 233.0
TLS2_k127_1259016_0 Peptidase family S58 K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 368.0
TLS2_k127_1259016_1 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 331.0
TLS2_k127_1259016_2 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001557 273.0
TLS2_k127_1259016_3 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000001429 241.0
TLS2_k127_1259016_4 acetyltransferase - - - 0.000000000000000000000000000000000000000001231 161.0
TLS2_k127_1259016_5 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000000000006006 169.0
TLS2_k127_1259016_6 PFAM sugar transferase - - - 0.0005809 42.0
TLS2_k127_12723_0 -O-antigen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006404 516.0
TLS2_k127_12723_1 PFAM glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 323.0
TLS2_k127_12723_2 Transglutaminase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001617 305.0
TLS2_k127_12723_3 PQQ enzyme repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000001454 233.0
TLS2_k127_12723_4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000001055 218.0
TLS2_k127_12723_5 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000009302 181.0
TLS2_k127_12723_6 - - - - 0.000000007248 62.0
TLS2_k127_12723_7 PFAM AIR synthase related protein - - - 0.000006086 52.0
TLS2_k127_12723_8 Phage integrase, N-terminal SAM-like domain - - - 0.000008774 49.0
TLS2_k127_1280082_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 8.268e-267 833.0
TLS2_k127_1280082_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007134 602.0
TLS2_k127_1280082_2 FtsX-like permease family K02003,K02004,K05685,K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 365.0
TLS2_k127_1280082_3 hemolysin III K11068 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006427 244.0
TLS2_k127_1280082_4 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000009631 259.0
TLS2_k127_1280082_5 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000006013 203.0
TLS2_k127_1280082_6 belongs to the thioredoxin family K01023,K03671 - 2.8.2.22 0.0000000000000000000000000000769 126.0
TLS2_k127_1280082_7 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000001355 126.0
TLS2_k127_1280180_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 593.0
TLS2_k127_1280180_1 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000001101 229.0
TLS2_k127_1280180_2 - - - - 0.000000000000000000000000000000000000000000000000000000001425 213.0
TLS2_k127_1280180_3 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000001553 207.0
TLS2_k127_1294302_0 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 329.0
TLS2_k127_1294302_1 PFAM sodium calcium exchanger membrane region K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 316.0
TLS2_k127_1294302_2 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000000000006633 206.0
TLS2_k127_1294302_3 - - - - 0.0000000000000000000149 95.0
TLS2_k127_1294302_4 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K04517 - 1.3.1.12 0.000000000005319 68.0
TLS2_k127_1294302_5 Belongs to the P(II) protein family K02806,K04752 - - 0.0000000001218 66.0
TLS2_k127_1294419_0 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 421.0
TLS2_k127_1294419_1 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.0000000000000000000000000000000000000000214 162.0
TLS2_k127_1299395_0 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 3.66e-207 656.0
TLS2_k127_1299395_1 ABC transporter substrate-binding protein PnrA-like K02058,K07335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 525.0
TLS2_k127_1299395_10 Putative transposase DNA-binding domain K07496 - - 0.0000001271 55.0
TLS2_k127_1299395_11 Transcriptional regulatory protein, C terminal - - - 0.0000003891 63.0
TLS2_k127_1299395_2 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 452.0
TLS2_k127_1299395_3 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005457 456.0
TLS2_k127_1299395_4 PFAM NAD-dependent epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 376.0
TLS2_k127_1299395_5 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001704 296.0
TLS2_k127_1299395_6 Phosphoglycerate mutase family - - - 0.000000000000000000000000000000000000000000000000001927 192.0
TLS2_k127_1299395_7 Polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000000005413 147.0
TLS2_k127_1299395_8 Peptidase M50 - - - 0.0000000000000001475 92.0
TLS2_k127_1299395_9 PFAM sigma-70 region 2 domain protein K03088 - - 0.000000000000000342 86.0
TLS2_k127_1311032_0 Glycosyl hydrolase family 63 C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004371 374.0
TLS2_k127_1311032_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000003642 204.0
TLS2_k127_1311032_2 ATP hydrolysis coupled proton transport - - - 0.00000000000000000000000000000000000000000001292 184.0
TLS2_k127_1311032_3 Endonuclease Exonuclease Phosphatase - - - 0.000000000000000000004985 101.0
TLS2_k127_1311032_5 PFAM glycosyl transferase family 39 - - - 0.000000000001404 81.0
TLS2_k127_1311032_6 NlpC/P60 family - - - 0.000001571 55.0
TLS2_k127_1312007_0 phosphate ion binding K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005559 376.0
TLS2_k127_1312007_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000005632 248.0
TLS2_k127_1312007_2 Transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000122 269.0
TLS2_k127_1312007_3 cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000005008 243.0
TLS2_k127_1312007_4 guanyl-nucleotide exchange factor activity K01179,K03929,K09612,K12287,K19701,K19702 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.2.1.4,3.4.11.10,3.4.11.24,3.4.11.6 0.0000000000000000000000000000000000000000000000000000000000001076 241.0
TLS2_k127_1312007_5 alginic acid biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000009086 203.0
TLS2_k127_1312007_6 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000000000001495 145.0
TLS2_k127_1312007_7 addiction module toxin, RelE StbE family K06218 - - 0.0000000000000000000000000839 109.0
TLS2_k127_1312007_8 SnoaL-like polyketide cyclase - - - 0.00006777 50.0
TLS2_k127_131798_0 carboxylase K01968 - 6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000411 470.0
TLS2_k127_131798_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006252 457.0
TLS2_k127_131798_2 Aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 289.0
TLS2_k127_131798_3 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03644,K03801 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181,2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000008271 266.0
TLS2_k127_131798_4 Transposase IS200 like - - - 0.000000000000000000000000000000000000000009485 160.0
TLS2_k127_131798_5 PFAM phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000002265 147.0
TLS2_k127_1335013_0 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity K00819,K00821 GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 606.0
TLS2_k127_1335013_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 480.0
TLS2_k127_1335013_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000189 218.0
TLS2_k127_1335013_3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000283 177.0
TLS2_k127_1335013_4 DNA polymerase alpha chain like domain - - - 0.00000000000000000000000000002927 119.0
TLS2_k127_1335013_5 - - - - 0.000000000000000007262 85.0
TLS2_k127_1335013_6 heme-binding sites - - - 0.0000007046 63.0
TLS2_k127_1352034_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.138e-224 719.0
TLS2_k127_1352034_1 Lamin Tail Domain K07004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007937 622.0
TLS2_k127_1352034_2 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005595 264.0
TLS2_k127_1370534_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 295.0
TLS2_k127_1370534_1 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000001115 178.0
TLS2_k127_1370534_2 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000004694 152.0
TLS2_k127_1370534_3 Cytochrome c K15864 - 1.7.2.1,1.7.99.1 0.0000000000000003854 85.0
TLS2_k127_1371373_0 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009405 556.0
TLS2_k127_1371373_1 phosphopantetheine binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 456.0
TLS2_k127_1371373_10 - - - - 0.00000000000000000000000000000000000000000000834 171.0
TLS2_k127_1371373_11 - - - - 0.00000000000000000000000000000000000000000002685 166.0
TLS2_k127_1371373_12 PFAM Abortive infection protein K07052 - - 0.0000000000000000000000000000000000001085 150.0
TLS2_k127_1371373_13 Belongs to the 'phage' integrase family K04763 - - 0.0000000000000000000000000008355 115.0
TLS2_k127_1371373_14 Phosphopantetheine attachment site - - - 0.00000000000000000001592 96.0
TLS2_k127_1371373_15 P22_AR N-terminal domain - - - 0.0000000000000002968 83.0
TLS2_k127_1371373_17 CAAX protease self-immunity - - - 0.00000001143 66.0
TLS2_k127_1371373_18 alpha/beta hydrolase fold - - - 0.00000007365 56.0
TLS2_k127_1371373_19 CAAX amino terminal protease family - - - 0.000003062 52.0
TLS2_k127_1371373_2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008007 411.0
TLS2_k127_1371373_3 COGs COG3321 Polyketide synthase modules and related protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 346.0
TLS2_k127_1371373_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 346.0
TLS2_k127_1371373_5 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004954 324.0
TLS2_k127_1371373_6 COGs COG1131 ABC-type multidrug transport system ATPase component K01990,K20459 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004978 312.0
TLS2_k127_1371373_7 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000001294 260.0
TLS2_k127_1371373_8 DinB family - - - 0.00000000000000000000000000000000000000000000000000001212 195.0
TLS2_k127_1371373_9 Phage integrase, N-terminal SAM-like domain - - - 0.000000000000000000000000000000000000000000000000005316 190.0
TLS2_k127_1376183_0 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000001238 240.0
TLS2_k127_1376183_1 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000000000000001621 209.0
TLS2_k127_1376183_2 phosphatase activity K07025 - - 0.00000000000000000000000000000000000000000000000118 184.0
TLS2_k127_1394857_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 2.929e-219 699.0
TLS2_k127_1394857_1 beta-glucosidase activity K05350,K21000 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007244 434.0
TLS2_k127_1394857_2 N-terminal 7TM region of histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009203 321.0
TLS2_k127_1394857_3 Belongs to the glutamate synthase family - - - 0.000000000000008105 75.0
TLS2_k127_1394857_4 ATPase family associated with various cellular activities (AAA) - - - 0.0000007547 59.0
TLS2_k127_1395725_0 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 370.0
TLS2_k127_1395725_1 PFAM AMP-dependent synthetase and ligase - - - 0.000000000000000000000000000000000000000000000003202 198.0
TLS2_k127_1395725_3 Protein of unknown function (DUF4230) - - - 0.000000000000000000000002793 113.0
TLS2_k127_1395725_4 Protein of unknown function (DUF503) K09764 - - 0.00000000000000000000001911 102.0
TLS2_k127_1410036_0 heavy metal translocating P-type ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 2.448e-296 930.0
TLS2_k127_1410036_1 glutamate-cysteine ligase activity K00836 - 2.6.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 484.0
TLS2_k127_1410036_2 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 442.0
TLS2_k127_1410036_3 PFAM DegV family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000427 245.0
TLS2_k127_1410036_4 Domain of Unknown Function (DUF326) - - - 0.0000000000000000000000000000000000000000000000004725 179.0
TLS2_k127_1410036_5 COG2010 Cytochrome c, mono- and diheme variants - - - 0.0000000000000000000000000000002461 128.0
TLS2_k127_1410036_6 - - - - 0.00000004095 60.0
TLS2_k127_1410036_7 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00001476 48.0
TLS2_k127_1420104_0 Zn_pept - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 606.0
TLS2_k127_1420104_1 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005614 348.0
TLS2_k127_1420104_2 diaminopimelate decarboxylase activity K01585,K01586 - 4.1.1.19,4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009285 328.0
TLS2_k127_1420104_3 PFAM glycosyl transferase, family 51 - - - 0.000000000000000000000002727 110.0
TLS2_k127_1420104_4 Calcineurin-like phosphoesterase - - - 0.00000000000000000000003208 116.0
TLS2_k127_1423432_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000952 554.0
TLS2_k127_1423432_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 520.0
TLS2_k127_1423432_2 DNA recombination-mediator protein A K03168,K04096 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006278 375.0
TLS2_k127_1423432_3 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 331.0
TLS2_k127_1423432_4 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000005053 181.0
TLS2_k127_1423432_5 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000166 147.0
TLS2_k127_1423432_6 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000004374 129.0
TLS2_k127_1423432_7 mitochondrial translation K02959 GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000007408 98.0
TLS2_k127_1423432_8 Belongs to the UPF0109 family K06960 - - 0.0000000000000000001679 90.0
TLS2_k127_1434748_0 Belongs to the DEAD box helicase family K03732,K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004433 578.0
TLS2_k127_1434748_1 Acyltransferase - - - 0.0000000000000000000000000001554 123.0
TLS2_k127_1436423_0 glycosyl transferase family 28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 326.0
TLS2_k127_1436423_1 COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes - - - 0.0000000000000000000000001572 109.0
TLS2_k127_1440659_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003746 286.0
TLS2_k127_1440659_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000002997 156.0
TLS2_k127_1440659_3 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000323 73.0
TLS2_k127_1445164_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.689e-232 749.0
TLS2_k127_1445164_1 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000004655 162.0
TLS2_k127_1445164_2 PFAM response regulator receiver K02658 - - 0.000000000000000000005728 97.0
TLS2_k127_1445164_3 Binds directly to 16S ribosomal RNA K02968 - - 0.00007283 48.0
TLS2_k127_1446556_0 ATPase family associated with various cellular activities (AAA) K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006533 572.0
TLS2_k127_1446556_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 333.0
TLS2_k127_1446556_2 PFAM Formylglycine-generating sulfatase enzyme K18912 - 1.14.99.50 0.00000000000000000000000000000000000000000004965 168.0
TLS2_k127_1446556_3 mechanosensitive ion channel - - - 0.0005208 49.0
TLS2_k127_1454498_0 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 482.0
TLS2_k127_1454498_1 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000002167 237.0
TLS2_k127_1454498_2 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0004742 44.0
TLS2_k127_1461304_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 2.431e-307 951.0
TLS2_k127_1461304_1 Protein of unknown function (DUF1116) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003326 535.0
TLS2_k127_1462015_0 PFAM Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000005971 229.0
TLS2_k127_1462015_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000006196 180.0
TLS2_k127_1462015_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000004967 108.0
TLS2_k127_1462015_3 SMART PAS domain containing protein - - - 0.000000000000000001343 87.0
TLS2_k127_1463760_0 translation release factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004194 368.0
TLS2_k127_1463760_1 cellulase activity K01183 - 3.2.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007309 344.0
TLS2_k127_1463760_2 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000002485 149.0
TLS2_k127_1463760_3 Tyrosine recombinase XerD K04763 GO:0008150,GO:0040007 - 0.0000000000000000000006374 108.0
TLS2_k127_1463760_4 Pkd domain containing protein - - - 0.0000000002712 73.0
TLS2_k127_1463760_5 Ami_3 K01448 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 0.000001614 61.0
TLS2_k127_1463760_6 META domain - - - 0.000003768 55.0
TLS2_k127_1484323_0 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004218 402.0
TLS2_k127_1484323_1 Phage shock protein A K03969 - - 0.0000000000000000000000000000000000000006265 157.0
TLS2_k127_1484323_2 Lipopolysaccharide biosynthesis protein - - - 0.0000000000000000000000000000004895 131.0
TLS2_k127_1484323_3 - - - - 0.00000000000000000000005974 103.0
TLS2_k127_1484323_4 PspC domain - - - 0.0000000000005755 71.0
TLS2_k127_1491497_0 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.00000000000000000000000000000000000000000000000000000000000000002348 231.0
TLS2_k127_1491497_1 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.00000000000000000000000000000000000000006711 161.0
TLS2_k127_1491497_2 Peptide ABC transporter substrate-binding protein K15580 - - 0.0000000000000000000000000000001163 142.0
TLS2_k127_1491497_3 SprB repeat - - - 0.0003129 47.0
TLS2_k127_1498130_0 Ethylbenzene dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 383.0
TLS2_k127_1498130_1 ATPase P-type (Transporting), HAD superfamily, subfamily IC - - - 0.000000000000000000000000000000000000000000000000000000000000002716 227.0
TLS2_k127_1498130_2 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.00000000000000000000000000000001765 143.0
TLS2_k127_1498130_3 - - - - 0.000000000000000000002242 100.0
TLS2_k127_1498130_4 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000002065 76.0
TLS2_k127_1498130_5 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.000000000002156 77.0
TLS2_k127_1498130_6 Protein of unknown function (DUF1573) - - - 0.0000000008608 67.0
TLS2_k127_1498130_7 Protein of unknown function (DUF1573) - - - 0.00000007177 59.0
TLS2_k127_1499133_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005247 574.0
TLS2_k127_1499133_1 Tryptophan halogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 452.0
TLS2_k127_1499133_2 PFAM Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004012 398.0
TLS2_k127_1499133_3 Tellurite resistance protein TehB - - - 0.000000000000000000000000000000000000000000000000000000000000001268 224.0
TLS2_k127_1499133_4 Hep Hag repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000003732 235.0
TLS2_k127_1508860_0 glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 316.0
TLS2_k127_1508860_1 Protein of unknown function (DUF2089) - - - 0.00000000000000000000000000001708 121.0
TLS2_k127_1508860_2 - - - - 0.000000000000000000000001992 109.0
TLS2_k127_1508860_3 domain, Protein - - - 0.000000000295 69.0
TLS2_k127_1508860_4 - - - - 0.000002912 58.0
TLS2_k127_1514000_0 PFAM type II secretion system protein K12511 - - 0.00000000000000000000000000000000000000000000000000000000000002049 225.0
TLS2_k127_1514000_1 Type II secretion system (T2SS), protein F K12510 - - 0.000000000000000000000000000000000000186 153.0
TLS2_k127_1514000_2 PFAM von Willebrand factor type A domain K07114 - - 0.00000000000000000000000000000000008729 147.0
TLS2_k127_1514099_0 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 438.0
TLS2_k127_1514099_1 Dehydrogenase K08322 - 1.1.1.380 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008353 325.0
TLS2_k127_1514099_2 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005712 276.0
TLS2_k127_1514099_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000002311 202.0
TLS2_k127_1514099_4 SMART PAS domain containing protein - - - 0.00000000000000000000000000000000000004606 161.0
TLS2_k127_1514099_5 Domain of unknown function (DUF4129) - - - 0.0000000000000000000007465 106.0
TLS2_k127_1514099_6 Flagellar filament outer layer protein Flaa - - - 0.00000000001896 76.0
TLS2_k127_1514099_7 amine dehydrogenase activity - - - 0.0002846 53.0
TLS2_k127_1516791_0 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 321.0
TLS2_k127_1516791_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005822 277.0
TLS2_k127_1516791_2 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000182 268.0
TLS2_k127_1522648_0 FAD linked oxidase domain protein K00102,K00104 - 1.1.2.4,1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008384 426.0
TLS2_k127_1522648_1 Mate efflux family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000012 263.0
TLS2_k127_1522648_2 PFAM OsmC family protein K07397 - - 0.00000000000000000000000000000000000002582 147.0
TLS2_k127_1522648_4 Winged helix DNA-binding domain - - - 0.000007628 50.0
TLS2_k127_1526552_0 transferase activity, transferring glycosyl groups K09118,K13693,K21349 - 2.4.1.266,2.4.1.268 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003377 580.0
TLS2_k127_1526552_1 PFAM Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 458.0
TLS2_k127_1526552_2 Belongs to the phosphoglycerate mutase family K15634 - 5.4.2.12 0.0000000000000000000000000000000000000000004452 165.0
TLS2_k127_1532724_0 DNA binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 359.0
TLS2_k127_153931_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 533.0
TLS2_k127_153931_1 calcium- and calmodulin-responsive adenylate cyclase activity K13735,K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 313.0
TLS2_k127_153931_2 ABC-3 protein K09819 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002439 280.0
TLS2_k127_153931_3 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000002097 133.0
TLS2_k127_153931_4 COG COG0791 Cell wall-associated hydrolases (invasion-associated proteins) - - - 0.0000000000000001499 93.0
TLS2_k127_153931_5 ATPases associated with a variety of cellular activities K02074,K09820,K19973 - 3.6.3.35 0.00000002085 59.0
TLS2_k127_1542600_0 ThiF family K21029,K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 536.0
TLS2_k127_1542600_1 Cysteine synthase B K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009091 361.0
TLS2_k127_1542600_2 PFAM YhhN family protein - - - 0.00000000000000000000000000000000000000000000000002425 188.0
TLS2_k127_1542600_3 ThiS family K03636 - - 0.0000000000000000000000000005107 116.0
TLS2_k127_1542600_4 PFAM Mov34 MPN PAD-1 family - - - 0.000000000000000000000006867 106.0
TLS2_k127_1551595_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000874 576.0
TLS2_k127_1551595_1 Glycyl-tRNA synthetase alpha subunit K14164 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009116 371.0
TLS2_k127_1551595_10 GGDEF domain - - - 0.000000000000000000000000000002386 139.0
TLS2_k127_1551595_11 Helix-turn-helix domain - - - 0.000000000000000000000000004271 122.0
TLS2_k127_1551595_12 - - - - 0.000000000000000000000001228 112.0
TLS2_k127_1551595_13 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000003064 100.0
TLS2_k127_1551595_14 - - - - 0.00000000000001792 81.0
TLS2_k127_1551595_15 Endoribonuclease that initiates mRNA decay K18682 - - 0.00000000000006281 72.0
TLS2_k127_1551595_16 virion core protein (lumpy skin disease virus) - - - 0.0000003427 64.0
TLS2_k127_1551595_2 MutL protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005827 277.0
TLS2_k127_1551595_3 Phage shock protein A K03969 - - 0.000000000000000000000000000000000000000000000000000000002088 211.0
TLS2_k127_1551595_4 PFAM diacylglycerol kinase catalytic region - - - 0.00000000000000000000000000000000000000000000000001833 190.0
TLS2_k127_1551595_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000766 180.0
TLS2_k127_1551595_7 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000001658 141.0
TLS2_k127_1551595_8 - - - - 0.00000000000000000000000000000005016 138.0
TLS2_k127_1551595_9 - - - - 0.00000000000000000000000000000005243 139.0
TLS2_k127_1560558_0 Methionine synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006413 390.0
TLS2_k127_1563506_0 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 7.568e-196 624.0
TLS2_k127_1563506_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K03851,K15372 - 2.6.1.55,2.6.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 414.0
TLS2_k127_1563506_10 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000000000000000002004 144.0
TLS2_k127_1563506_11 Protein of unknown function (DUF433) - - - 0.0000000000000000000000000000004643 124.0
TLS2_k127_1563506_12 PIN domain - - - 0.0000000000000000000000009251 109.0
TLS2_k127_1563506_13 Arc-like DNA binding domain K21495 - - 0.00000001249 59.0
TLS2_k127_1563506_2 Coenzyme A transferase K01039 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 383.0
TLS2_k127_1563506_3 Cation transport protein K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007313 315.0
TLS2_k127_1563506_4 Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003608 273.0
TLS2_k127_1563506_5 Peptidase_C39 like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003303 261.0
TLS2_k127_1563506_6 Peptidase_C39 like family - - - 0.000000000000000000000000000000000000000000000000000000000000003195 235.0
TLS2_k127_1563506_7 PFAM transglutaminase domain protein - - - 0.0000000000000000000000000000000000000000000000000002785 209.0
TLS2_k127_1563506_8 TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000001726 160.0
TLS2_k127_1563506_9 Histidine phosphatase superfamily (branch 1) - - - 0.00000000000000000000000000000000001782 142.0
TLS2_k127_1569504_0 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 460.0
TLS2_k127_1569504_1 stress-induced mitochondrial fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 443.0
TLS2_k127_1569504_2 PFAM band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 351.0
TLS2_k127_1569504_3 PFAM phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000003835 184.0
TLS2_k127_1585341_0 Polysaccharide biosynthesis protein - - - 8.854e-242 797.0
TLS2_k127_1585341_1 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001795 272.0
TLS2_k127_1585341_2 4-vinyl reductase, 4VR - - - 0.0000000000000000000000000000000000000000000000000000006681 196.0
TLS2_k127_1585341_3 UDP-glucoronosyl and UDP-glucosyl transferase K05841 - 2.4.1.173 0.000000000000007407 76.0
TLS2_k127_1601452_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 3.353e-277 862.0
TLS2_k127_1601452_1 Secretion protein - - - 0.00001352 56.0
TLS2_k127_1616823_0 FtsJ-like methyltransferase K06968 - 2.1.1.186 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 384.0
TLS2_k127_1616823_1 Protein of unknown function (DUF1298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 352.0
TLS2_k127_1616823_2 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006949 277.0
TLS2_k127_1616823_3 response regulator - - - 0.0008731 44.0
TLS2_k127_1618550_0 SMART protein phosphatase 2C domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 488.0
TLS2_k127_1618550_1 ABC transporter transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 446.0
TLS2_k127_1618550_2 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749,K04757 - 2.7.11.1 0.000000000000000000000000004573 115.0
TLS2_k127_1618550_3 STAS domain K04749 - - 0.00000000000001079 78.0
TLS2_k127_1618550_4 STAS domain K06378 - - 0.000000000006677 70.0
TLS2_k127_1623419_0 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine - - - 1.488e-233 741.0
TLS2_k127_1623419_1 Pyrimidine nucleoside phosphorylase C-terminal domain K00756,K00758 GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016757,GO:0016758,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 473.0
TLS2_k127_1623419_2 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000001555 175.0
TLS2_k127_1623419_3 Protein of unknown function (DUF5131) - - - 0.000000000000000000000000208 105.0
TLS2_k127_1623419_4 sterol carrier protein - - - 0.000000000000000005493 87.0
TLS2_k127_1623419_5 ROK family K00886 - 2.7.1.63 0.00000004314 55.0
TLS2_k127_1627523_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.318e-285 894.0
TLS2_k127_1627523_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 2.109e-237 746.0
TLS2_k127_1634634_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 623.0
TLS2_k127_1634634_1 ECF sigma factor K03088 - - 0.000000000000000000000000000005336 128.0
TLS2_k127_1634634_2 Anti-sigma-K factor rskA - - - 0.00008475 53.0
TLS2_k127_1644928_0 SPTR Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000959 235.0
TLS2_k127_1644928_1 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000237 150.0
TLS2_k127_1644928_2 protein kinase activity - - - 0.000000000000000000000000000005894 139.0
TLS2_k127_1644928_3 Phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.000000000000000000000001389 106.0
TLS2_k127_1644928_4 Protein of unknown function (DUF2723) - - - 0.000000000000000000000002505 121.0
TLS2_k127_1646281_0 Alpha-2-macroglobulin family K06894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 345.0
TLS2_k127_1659584_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 3.564e-286 887.0
TLS2_k127_1659584_1 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006879 481.0
TLS2_k127_1659584_10 - - - - 0.00000000000000000000001025 102.0
TLS2_k127_1659584_11 Ribosomal protein S21 K02970 - - 0.0000000000001383 72.0
TLS2_k127_1659584_2 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 356.0
TLS2_k127_1659584_3 PFAM sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008261 260.0
TLS2_k127_1659584_4 Deoxynucleoside kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001082 256.0
TLS2_k127_1659584_5 PFAM metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000154 261.0
TLS2_k127_1659584_6 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000008666 215.0
TLS2_k127_1659584_7 FCD domain - - - 0.0000000000000000000000000000000000000000000000000002147 193.0
TLS2_k127_1659584_8 thiolester hydrolase activity K06889 - - 0.00000000000000000000000000000000000000000007033 175.0
TLS2_k127_1659584_9 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000008392 127.0
TLS2_k127_1669561_0 ABC transporter K02056,K10441 - 3.6.3.17 2.845e-199 632.0
TLS2_k127_1669561_1 Belongs to the binding-protein-dependent transport system permease family K02057,K10440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 400.0
TLS2_k127_1669561_2 Belongs to the binding-protein-dependent transport system permease family K02057,K10440 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006518 378.0
TLS2_k127_1669561_3 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 325.0
TLS2_k127_1669561_4 Glutamine cyclotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 302.0
TLS2_k127_1669561_5 Periplasmic binding protein domain K02058 - - 0.00000000000000000000000000000000000000000000000000000002599 199.0
TLS2_k127_1669561_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000003351 184.0
TLS2_k127_1691232_0 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 616.0
TLS2_k127_1691232_1 Binding-protein-dependent transport system inner membrane component K17319 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 399.0
TLS2_k127_1691232_2 Binding-protein-dependent transport system inner membrane component K17320 - - 0.000000000000000000000000000000000000000000000000000009785 196.0
TLS2_k127_1693639_0 lipoprotein biosynthetic process - - - 0.000000000000000000000000000002721 133.0
TLS2_k127_1704541_0 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 3.057e-252 786.0
TLS2_k127_1704541_1 Carbamoyl-phosphate synthetase large chain domain protein K01961,K01968,K11263 - 6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4 1.556e-198 631.0
TLS2_k127_1704541_2 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 333.0
TLS2_k127_1704541_3 Transcriptional regulatory protein, C terminal K07658 - - 0.000000000000000000000000000000000000000000002916 169.0
TLS2_k127_1704541_4 CoA carboxylase activity K01965,K02160 - 6.4.1.3 0.00000000000000000000000000000001592 132.0
TLS2_k127_1708432_0 NADPH:quinone reductase activity K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 364.0
TLS2_k127_1708432_1 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 366.0
TLS2_k127_1708432_2 - - - - 0.000000000000000000000000000000000000000000000009762 180.0
TLS2_k127_1708432_3 peptidase C60 sortase A and B K07284 - 3.4.22.70 0.00000000000000000000000000000008745 134.0
TLS2_k127_1708432_4 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.00000000000000000000000000738 114.0
TLS2_k127_1708432_5 PFAM Formylglycine-generating sulfatase enzyme - - - 0.0005502 47.0
TLS2_k127_1709573_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 8.899e-197 619.0
TLS2_k127_1709573_1 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 508.0
TLS2_k127_1709573_2 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 330.0
TLS2_k127_1709573_3 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000002529 238.0
TLS2_k127_1709573_4 AntiSigma factor - - - 0.00000000000000000001995 99.0
TLS2_k127_1709918_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003897 364.0
TLS2_k127_1709918_1 PFAM metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002253 263.0
TLS2_k127_1709918_2 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000007225 143.0
TLS2_k127_1711401_0 PFAM Adenosine AMP deaminase K01488 - 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005363 343.0
TLS2_k127_1711401_1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000001862 267.0
TLS2_k127_1711401_2 PFAM diacylglycerol kinase catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000012 247.0
TLS2_k127_1711401_3 Integral membrane sensor signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000003117 207.0
TLS2_k127_1711401_4 methyltransferase K00563,K10947 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008270,GO:0008649,GO:0008757,GO:0008989,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0052912,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.187 0.000000000000000000000000000000000000000000001705 176.0
TLS2_k127_1711401_5 Protein conserved in bacteria - - - 0.000000000000000000000000000000000006939 141.0
TLS2_k127_1711401_6 Chromatin associated protein KTI12 - - - 0.0000001494 61.0
TLS2_k127_1718681_0 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003723 321.0
TLS2_k127_1718681_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006435 310.0
TLS2_k127_1718681_2 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000004821 231.0
TLS2_k127_1718681_3 Histidine kinase K07777,K19661,K21405 - 2.7.13.3 0.000000000000000000000000000000000000000000000000002123 203.0
TLS2_k127_1718681_4 Predicted membrane protein (DUF2085) - - - 0.000000000000000000000000000000000000000000003184 171.0
TLS2_k127_1718681_5 - - - - 0.000000000000000000000411 99.0
TLS2_k127_1732649_0 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002704 253.0
TLS2_k127_1734596_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K12952 - - 1.142e-195 638.0
TLS2_k127_1734596_1 protein histidine kinase activity K02484,K07636,K07642 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016036,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035556,GO:0036211,GO:0042578,GO:0042594,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000753 381.0
TLS2_k127_1734596_10 Domain of unknown function (DUF4349) - - - 0.000000000000000000000000001422 124.0
TLS2_k127_1734596_11 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000001797 105.0
TLS2_k127_1734596_13 SPFH domain / Band 7 family - - - 0.0000000000006156 70.0
TLS2_k127_1734596_14 Aminoglycoside phosphotransferase - - - 0.000000399 62.0
TLS2_k127_1734596_15 Domain of unknown function (DUF4349) - - - 0.0002709 51.0
TLS2_k127_1734596_2 peptidase M42 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 345.0
TLS2_k127_1734596_3 overlaps another CDS with the same product name - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009991 326.0
TLS2_k127_1734596_4 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 315.0
TLS2_k127_1734596_5 Bacterial membrane protein YfhO - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005901 287.0
TLS2_k127_1734596_6 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009118 272.0
TLS2_k127_1734596_7 PFAM Glycosyl transferase family 2 K20444 - - 0.00000000000000000000000000000000000000000000000000000000000719 225.0
TLS2_k127_1734596_8 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000001406 196.0
TLS2_k127_1734596_9 Psort location CytoplasmicMembrane, score K00368 - 1.7.2.1 0.000000000000000000000000000000000000000009134 178.0
TLS2_k127_1753468_0 Belongs to the glycosyl hydrolase 13 family - - - 0.0 1193.0
TLS2_k127_1770783_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008938 563.0
TLS2_k127_1770783_1 ADP-ribosylglycohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 347.0
TLS2_k127_1770783_10 - - - - 0.000000009909 60.0
TLS2_k127_1770783_2 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 293.0
TLS2_k127_1770783_3 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 296.0
TLS2_k127_1770783_4 Cache domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001989 279.0
TLS2_k127_1770783_5 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000000001109 173.0
TLS2_k127_1770783_6 Transcriptional regulatory protein WalR K07668 GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000001573 107.0
TLS2_k127_1770783_7 Cold shock protein domain K03704 - - 0.0000000000000007538 78.0
TLS2_k127_1770783_9 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.000000000008429 70.0
TLS2_k127_1771491_0 PFAM ATPase associated with various cellular activities, AAA_5 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 441.0
TLS2_k127_1771491_1 Uncharacterized protein family UPF0029 K00560,K01271 - 2.1.1.45,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000166 221.0
TLS2_k127_1771491_2 Helix-turn-helix domain - - - 0.00000000000000000000000000000002641 127.0
TLS2_k127_1771491_3 Acetyltransferase (GNAT) domain K22441 - 2.3.1.57 0.00000002978 64.0
TLS2_k127_1771491_4 Phage derived protein Gp49-like (DUF891) - - - 0.000008774 50.0
TLS2_k127_1778503_0 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000001825 200.0
TLS2_k127_1778503_1 - - - - 0.00000000000000000000000000000000000000403 150.0
TLS2_k127_1778503_2 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.0004408 52.0
TLS2_k127_1782819_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 564.0
TLS2_k127_1782819_1 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 311.0
TLS2_k127_1782819_2 guanyl-nucleotide exchange factor activity K01179,K03929,K09612,K12287,K19701,K19702 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.2.1.4,3.4.11.10,3.4.11.24,3.4.11.6 0.00000000000000000000000000000000000003921 167.0
TLS2_k127_1782819_3 cAMP biosynthetic process K01768,K10393 - 4.6.1.1 0.00000000000000000000000000000000002756 156.0
TLS2_k127_1782819_4 PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP K20276 - - 0.00000000000000000000000000000000005112 156.0
TLS2_k127_1782819_5 Pectate lyase K21606 - 3.2.1.202 0.00001091 59.0
TLS2_k127_1782819_6 PFAM extracellular solute-binding protein family 1 K02027,K10236 - - 0.0001215 54.0
TLS2_k127_1785506_1 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006453 621.0
TLS2_k127_1785506_2 Domain of unknown function (DUF3390) K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 429.0
TLS2_k127_1785506_3 PFAM Uncharacterised ACR, YkgG family COG1556 K00782 - - 0.00000000000000000000004419 106.0
TLS2_k127_1812931_0 PFAM lipopolysaccharide biosynthesis protein K08253,K16554,K16692 - 2.7.10.2 0.00000000000000000000000000000000000000000001029 169.0
TLS2_k127_1812931_1 Domain of unknown function DUF83 K07464 - 3.1.12.1 0.000000000000000000000000000000000000001159 153.0
TLS2_k127_1812931_2 Glycogen debranching enzyme - - - 0.00000000000000000004297 104.0
TLS2_k127_1812931_3 Capsular exopolysaccharide family - - - 0.000000000000000000606 90.0
TLS2_k127_1822770_0 tRNA-splicing ligase RtcB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 548.0
TLS2_k127_1822770_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K15408 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 303.0
TLS2_k127_1822770_2 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K17223 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004734 298.0
TLS2_k127_1822770_3 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.00000000000000000000000000000000000000000000000000000000000005151 225.0
TLS2_k127_18336_0 Domain of unknown function (DUF4445) - - - 7.695e-307 953.0
TLS2_k127_18336_1 Transketolase, pyrimidine binding domain - - - 1.163e-254 803.0
TLS2_k127_18336_10 Protein of unknown function (DUF433) - - - 0.00000000000000000000000000001121 119.0
TLS2_k127_18336_11 - - - - 0.000000000000000000004116 97.0
TLS2_k127_18336_12 ABC-type proline glycine betaine transport system permease component K02001 - - 0.00000000000004896 78.0
TLS2_k127_18336_13 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000005376 74.0
TLS2_k127_18336_14 Virulence factor - - - 0.0000000006729 66.0
TLS2_k127_18336_16 - - - - 0.00003922 47.0
TLS2_k127_18336_17 Glycine betaine K02001,K02002 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0072337 - 0.00005403 47.0
TLS2_k127_18336_2 Pfam:Arch_ATPase - - - 1.606e-223 723.0
TLS2_k127_18336_3 COG COG1454 Alcohol dehydrogenase class IV Energy production and conversion K00086,K11440 - 1.1.1.1,1.1.1.202 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 441.0
TLS2_k127_18336_4 ABC-type proline glycine betaine transport system permease component K02001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 394.0
TLS2_k127_18336_5 COG4175 ABC-type proline glycine betaine transport system ATPase component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 381.0
TLS2_k127_18336_6 cobalamin binding K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005964 367.0
TLS2_k127_18336_7 Homocysteine S-methyltransferase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 332.0
TLS2_k127_18336_8 Protein of unknown function (DUF4058) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002459 248.0
TLS2_k127_18336_9 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000001303 160.0
TLS2_k127_1842264_0 Bacterial membrane protein YfhO - - - 0.00000000000000000000000000000000000000000000000000000000000001301 239.0
TLS2_k127_1843865_0 Integral membrane sensor signal transduction histidine kinase K07680,K07778,K11617,K14988 - 2.7.13.3 0.00000000000000000000000001799 124.0
TLS2_k127_1858310_0 Protein of unknown function (DUF4011) - - - 0.0 1050.0
TLS2_k127_1858310_1 Asparaginase K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 392.0
TLS2_k127_1858310_2 Integral membrane protein DUF92 - - - 0.000000000000000000000000000000000000000000000000000000000000000000003322 243.0
TLS2_k127_1858310_3 COG0500 SAM-dependent methyltransferases - - - 0.00000000000000000000000000000000000000000000000000000002317 205.0
TLS2_k127_1858310_4 Transcriptional regulator K02529 - - 0.00000000000000002255 84.0
TLS2_k127_1858310_5 Beta-galactosidase C-terminal domain K12308 - 3.2.1.23 0.000000000000001691 80.0
TLS2_k127_1858310_6 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000001998 71.0
TLS2_k127_1858310_7 Belongs to the glycosyl hydrolase family 6 K19551 - 4.2.2.10,4.2.2.2 0.00000001151 66.0
TLS2_k127_1858310_8 - - - - 0.00002085 49.0
TLS2_k127_1860650_0 haloacid dehalogenase-like hydrolase K01534 - 3.6.3.3,3.6.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 499.0
TLS2_k127_1860650_1 Protein conserved in bacteria K07011 - - 0.00000000000000000000000000000000000000000000000000000001143 204.0
TLS2_k127_1860650_2 5-methylcytosine restriction system K19147 - - 0.000000000000000000000000000000000000001149 151.0
TLS2_k127_1863497_0 Putative cyclase - - - 2.531e-267 833.0
TLS2_k127_1863497_1 TIGRFAM drug resistance transporter, EmrB QacA subfamily K18926 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 403.0
TLS2_k127_1863497_2 intracellular signal transduction - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 357.0
TLS2_k127_1864841_0 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 345.0
TLS2_k127_1864841_1 PFAM ABC transporter related K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 321.0
TLS2_k127_1864841_10 PFAM glycosyl transferase family 39 - - - 0.0002687 53.0
TLS2_k127_1864841_2 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009507 322.0
TLS2_k127_1864841_3 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006328 316.0
TLS2_k127_1864841_4 PFAM ornithine cyclodeaminase mu-crystallin K01750 - 4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003115 287.0
TLS2_k127_1864841_5 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000008301 200.0
TLS2_k127_1864841_6 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000001504 143.0
TLS2_k127_1864841_7 - - - - 0.00000000000000000000000000000000008159 148.0
TLS2_k127_1864841_8 - - - - 0.0000000000000005119 91.0
TLS2_k127_1864841_9 Glycosyltransferase family 87 - - - 0.000000000000003584 88.0
TLS2_k127_1868554_0 PFAM VWA containing CoxE family protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 302.0
TLS2_k127_1868554_1 Belongs to the TPP enzyme family - - - 0.00000000000000000003176 107.0
TLS2_k127_1868554_2 TIGRFAM Bacterial surface protein 26-residue repeat - - - 0.000000000000008123 89.0
TLS2_k127_1868972_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004512 574.0
TLS2_k127_1868972_1 Sulfatase K01138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 518.0
TLS2_k127_1868972_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000004484 184.0
TLS2_k127_1868972_3 AAA domain - - - 0.00000000000000000000000000000000000006516 149.0
TLS2_k127_1868972_4 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.000000007859 57.0
TLS2_k127_1869461_0 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005935 390.0
TLS2_k127_1869461_1 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001249 249.0
TLS2_k127_1869461_2 Beta-lactamase enzyme family - - - 0.00000000000000000000000000000000000000000000000000005499 206.0
TLS2_k127_1869461_3 Membrane - - - 0.000000003353 70.0
TLS2_k127_189099_0 hydrolase activity, hydrolyzing O-glycosyl compounds K00701 - 2.4.1.19 1.038e-270 846.0
TLS2_k127_189099_1 Trimethylamine methyltransferase (MTTB) K14083 - 2.1.1.250 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 452.0
TLS2_k127_1896409_0 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 289.0
TLS2_k127_1899909_0 PFAM glycosyl transferase, family 51 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 569.0
TLS2_k127_1900118_0 belongs to the NAD synthetase family K01950 GO:0000166,GO:0003674,GO:0003824,GO:0003952,GO:0004359,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.1 1.482e-281 881.0
TLS2_k127_1900118_1 Sodium/hydrogen exchanger family K03455 - - 1.956e-255 803.0
TLS2_k127_1919916_0 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 426.0
TLS2_k127_1919916_1 Trypsin-like peptidase domain - - - 0.00000000000000000000000001941 117.0
TLS2_k127_1919916_2 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.00000000000000251 80.0
TLS2_k127_1919916_3 Protein of unknown function (DUF3352) - - - 0.000004417 60.0
TLS2_k127_1923097_1 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008536 376.0
TLS2_k127_1923097_2 Mechanosensitive ion channel K03442 - - 0.0000000000000000000000000000000000000000000002521 179.0
TLS2_k127_1923195_0 inositol 2-dehydrogenase activity - - - 4.695e-216 677.0
TLS2_k127_1923195_1 tagaturonate epimerase K21619 - 5.1.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 557.0
TLS2_k127_1923195_2 Pectate lyase K01728 - 4.2.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008344 458.0
TLS2_k127_1923195_3 lactate racemase activity K22373 - 5.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008441 441.0
TLS2_k127_1923195_4 Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 386.0
TLS2_k127_1923195_5 Glycosyl Hydrolase Family 88 K15532 - 3.2.1.172 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 354.0
TLS2_k127_1923195_6 KduI/IolB family K03337 - 5.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 352.0
TLS2_k127_1923195_7 PFAM short-chain dehydrogenase reductase SDR K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 329.0
TLS2_k127_1923768_0 Sigma-70, region 4 - - - 0.0000016 53.0
TLS2_k127_1929245_0 Hydantoinaseoxoprolinase domain protein K01473 - 3.5.2.14 4.316e-201 646.0
TLS2_k127_1929245_1 Transcriptional regulatory protein, C terminal K07667 - - 0.000000000000000000000000000000000000000003746 164.0
TLS2_k127_1929245_2 NUDIX domain - - - 0.0000000000000000000000000000000000000001369 161.0
TLS2_k127_1929245_3 Two component transcriptional regulator, winged helix family K07667,K07668 - - 0.00000000000000000000000000000000000004903 154.0
TLS2_k127_1930020_0 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009374 380.0
TLS2_k127_1930020_1 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004063 344.0
TLS2_k127_1930020_2 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 319.0
TLS2_k127_1930020_3 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009505 312.0
TLS2_k127_1930020_4 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 291.0
TLS2_k127_1930020_5 TIGRFAM geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004598 293.0
TLS2_k127_1930020_6 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007279 287.0
TLS2_k127_1930020_7 peptidase - - - 0.0000000000009008 77.0
TLS2_k127_1933273_0 PFAM acyl-CoA dehydrogenase domain protein K00255,K11731 - 1.3.8.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002323 595.0
TLS2_k127_1933273_1 homoserine kinase type II (Protein kinase fold) - - - 0.00000000000000000000000006828 114.0
TLS2_k127_1938412_0 COGs COG0647 sugar phosphatase of the HAD superfamily K01101,K02566 - 3.1.3.41 0.000000000000000000000000000000000000000002219 163.0
TLS2_k127_1938412_1 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000000000000002567 152.0
TLS2_k127_194146_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008391 528.0
TLS2_k127_194146_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000004329 251.0
TLS2_k127_1945696_0 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 1.558e-222 702.0
TLS2_k127_1945696_1 PFAM ABC transporter related K06158 - - 2.174e-221 706.0
TLS2_k127_1945696_2 PFAM peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001038 278.0
TLS2_k127_1945696_3 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000005377 177.0
TLS2_k127_1945696_4 Flagellar filament outer layer protein Flaa - - - 0.0000000000000002104 93.0
TLS2_k127_1945696_6 intracellular signal transduction - - - 0.00000000007296 74.0
TLS2_k127_1945696_7 Methyltransferase domain - - - 0.0000000001581 64.0
TLS2_k127_1959433_0 histidine kinase dimerisation and phosphoacceptor region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 519.0
TLS2_k127_1959433_1 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 328.0
TLS2_k127_1959433_10 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.00000000000000000000001185 104.0
TLS2_k127_1959433_11 Thioredoxin domain - - - 0.00000000000000000000002387 102.0
TLS2_k127_1959433_2 Belongs to the glycosyl hydrolase family 6 K01179,K19668 - 3.2.1.4,3.2.1.91 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005829 301.0
TLS2_k127_1959433_3 Sigma-70, region 4 type 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000224 249.0
TLS2_k127_1959433_4 PFAM Vitamin K epoxide reductase - - - 0.000000000000000000000000000000000000000000000000000000001303 215.0
TLS2_k127_1959433_5 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000002512 136.0
TLS2_k127_1959433_6 DGC domain - - - 0.0000000000000000000000000000000002793 141.0
TLS2_k127_1959433_7 OsmC-like protein - - - 0.000000000000000000000000000000000732 138.0
TLS2_k127_1959433_8 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000002327 128.0
TLS2_k127_1959433_9 DGC domain - - - 0.0000000000000000000000003328 110.0
TLS2_k127_1960310_0 domain, Protein K01219,K17624 - 3.2.1.81,3.2.1.97 1.01e-240 765.0
TLS2_k127_1960310_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 1.285e-218 686.0
TLS2_k127_1960310_2 denitrification pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008649 307.0
TLS2_k127_1960310_3 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 301.0
TLS2_k127_1960310_4 formate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007638 270.0
TLS2_k127_1960310_5 phosphatidylinositol metabolic process - - - 0.00000000000000000000000000000000000000000000000000000000000000001167 237.0
TLS2_k127_1964922_0 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 439.0
TLS2_k127_1964922_1 PFAM sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004948 324.0
TLS2_k127_1964922_2 PFAM O-antigen polymerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000046 332.0
TLS2_k127_1964922_3 Sulfotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002436 251.0
TLS2_k127_1964922_4 lipopolysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000005013 221.0
TLS2_k127_1964922_5 PFAM polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000001437 205.0
TLS2_k127_1964922_6 Protein conserved in bacteria K20444 - - 0.00000000000000000000001076 110.0
TLS2_k127_1966315_0 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004306 325.0
TLS2_k127_1966315_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000003151 248.0
TLS2_k127_1966315_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000002893 119.0
TLS2_k127_197677_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 495.0
TLS2_k127_197677_1 protein serine/threonine phosphatase activity K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000008997 180.0
TLS2_k127_197677_2 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000372 50.0
TLS2_k127_197677_3 Type IV pilus biogenesis stability protein PilW - - - 0.000828 50.0
TLS2_k127_1978855_0 Putative transposase DNA-binding domain K07496 - - 0.0000000000000000000003872 97.0
TLS2_k127_1978855_1 Cellulase (glycosyl hydrolase family 5) - - - 0.0000000000000000003223 102.0
TLS2_k127_1991137_0 PFAM alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 577.0
TLS2_k127_1991137_1 cellulase activity K01183 - 3.2.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 362.0
TLS2_k127_1991137_2 inorganic diphosphatase activity K15986 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 329.0
TLS2_k127_1991137_3 phosphotransferase activity, carboxyl group as acceptor - - - 0.00000000000000000000000000000000000000000000000000000005755 201.0
TLS2_k127_1991137_4 PFAM Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000001104 179.0
TLS2_k127_1991137_5 protein histidine kinase activity - - - 0.00000000000000000000000000000000000000000001137 167.0
TLS2_k127_1991137_7 PFAM response regulator receiver K02282 - - 0.00000000000000000000000000002506 125.0
TLS2_k127_201765_0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 288.0
TLS2_k127_201765_1 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000789 228.0
TLS2_k127_201765_2 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000002477 146.0
TLS2_k127_2038858_0 L-aspartate oxidase K00278 - 1.4.3.16 1.492e-225 709.0
TLS2_k127_2038858_1 - - - - 1.282e-194 623.0
TLS2_k127_2038858_10 PFAM Bacterial regulatory proteins, tetR family - - - 0.00000000000001506 81.0
TLS2_k127_2038858_11 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity K03429 - 2.4.1.315 0.000000000001243 70.0
TLS2_k127_2038858_12 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000006742 78.0
TLS2_k127_2038858_13 lactoylglutathione lyase activity - - - 0.000000001964 59.0
TLS2_k127_2038858_14 PFAM glycosyl transferase family 39 - - - 0.000000872 62.0
TLS2_k127_2038858_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 528.0
TLS2_k127_2038858_3 PFAM Cys Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000655 516.0
TLS2_k127_2038858_4 PFAM SMC domain protein K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009883 444.0
TLS2_k127_2038858_5 COGs COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs K00375 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 385.0
TLS2_k127_2038858_6 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 319.0
TLS2_k127_2038858_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11356 - 2.7.13.3 0.00000000000000000000000000000000000000000001759 183.0
TLS2_k127_2038858_8 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000000000000000000001087 117.0
TLS2_k127_2038858_9 Protein of unknown function (DUF983) - - - 0.000000000000000000000000662 108.0
TLS2_k127_2039507_0 Filamentation induced by cAMP protein fic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004299 280.0
TLS2_k127_2039507_1 Involved in the TonB-independent uptake of proteins K03641 - - 0.000005165 58.0
TLS2_k127_2039507_2 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0006878 52.0
TLS2_k127_2040148_0 Heat shock 70 kDa protein K04043 - - 4.939e-213 670.0
TLS2_k127_2040148_1 Heat shock protein DnaJ domain protein K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000434 361.0
TLS2_k127_2040148_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030554,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071840,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.00000000000000000000006836 109.0
TLS2_k127_2043539_0 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005045 519.0
TLS2_k127_2043539_1 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 297.0
TLS2_k127_2043539_2 SMART AAA ATPase - - - 0.00000000000000000000000000000006363 137.0
TLS2_k127_2043539_3 Two component transcriptional regulator, luxr family - - - 0.00000000000000003452 91.0
TLS2_k127_2044551_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003216 417.0
TLS2_k127_2044551_1 4-alpha-glucanotransferase K00700,K00705,K02438,K06044 GO:0000023,GO:0000025,GO:0003674,GO:0003824,GO:0004133,GO:0004134,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005984,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0055114,GO:0071704,GO:1901575 2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007592 363.0
TLS2_k127_2044551_2 Polysaccharide deacetylase K22278 - 3.5.1.104 0.00000001503 62.0
TLS2_k127_2047398_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 2.427e-205 647.0
TLS2_k127_2047398_1 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0007807 45.0
TLS2_k127_2047562_0 Belongs to the peptidase S8 family - - - 1.816e-211 697.0
TLS2_k127_2047562_1 CHASE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 539.0
TLS2_k127_2047562_10 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.00000000000000000000000000000004806 127.0
TLS2_k127_2047562_11 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000002832 120.0
TLS2_k127_2047562_2 Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 364.0
TLS2_k127_2047562_3 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 324.0
TLS2_k127_2047562_4 PFAM Polynucleotide adenylyltransferase region K00970,K00974 - 2.7.7.19,2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 308.0
TLS2_k127_2047562_5 PFAM thymidine kinase K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002377 271.0
TLS2_k127_2047562_6 4-amino-4-deoxy-L-arabinose transferase activity K14340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002035 263.0
TLS2_k127_2047562_7 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000001884 221.0
TLS2_k127_2047562_8 Cobalamin B12-binding K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000004785 192.0
TLS2_k127_2047562_9 Binds the 23S rRNA K02909 - - 0.00000000000000000000000000000000007136 138.0
TLS2_k127_2054483_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 - 3.4.21.83 9.221e-249 785.0
TLS2_k127_2054483_1 PFAM ABC transporter transmembrane region K06147 - - 7.562e-245 771.0
TLS2_k127_2054483_10 glyoxalase III activity - - - 0.000000000000000000000000000000153 125.0
TLS2_k127_2054483_11 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000001002 123.0
TLS2_k127_2054483_12 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01055 - 3.1.1.24 0.0000000000000000009045 95.0
TLS2_k127_2054483_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000002504 69.0
TLS2_k127_2054483_2 PFAM ABC transporter transmembrane region K06147 - - 1.774e-232 741.0
TLS2_k127_2054483_3 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 347.0
TLS2_k127_2054483_4 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 319.0
TLS2_k127_2054483_5 alpha beta - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 292.0
TLS2_k127_2054483_6 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000000000007141 263.0
TLS2_k127_2054483_7 PFAM LmbE family protein K18455 - 3.5.1.115 0.000000000000000000000000000000000000000000000000000000000000000000000009867 252.0
TLS2_k127_2054483_8 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000003104 197.0
TLS2_k127_2054483_9 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000006973 184.0
TLS2_k127_2054505_0 acyl-CoA dehydrogenase activity K09456 - - 1.023e-235 741.0
TLS2_k127_2054505_1 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 552.0
TLS2_k127_2054505_10 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00000000000000000000000000000000000000000000000000000001603 209.0
TLS2_k127_2054505_11 CAAX protease self-immunity - - - 0.00000000000000000000000000000000000000000003401 171.0
TLS2_k127_2054505_12 HicB family - - - 0.00000000000000000000000000000000000000000113 161.0
TLS2_k127_2054505_13 PhoQ Sensor K07682 GO:0000166,GO:0000287,GO:0001666,GO:0003032,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009593,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0019825,GO:0019826,GO:0020037,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042165,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0051606,GO:0051775,GO:0051776,GO:0070025,GO:0070026,GO:0070482,GO:0070483,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 0.00000000000000000000000000000000000000087 163.0
TLS2_k127_2054505_14 Transcriptional regulator K18939 - - 0.0000000000000000000000000000000000003655 146.0
TLS2_k127_2054505_15 Transglycosylase associated protein - - - 0.00000000000000000000000000002746 121.0
TLS2_k127_2054505_16 Protein of unknown function DUF86 - - - 0.000000000000000000000000002716 114.0
TLS2_k127_2054505_17 Thioesterase K07107,K12500 - - 0.000000000000000000000000003311 119.0
TLS2_k127_2054505_18 PFAM regulatory protein TetR K03577,K18939 - - 0.000000000000000000000000009413 117.0
TLS2_k127_2054505_2 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 550.0
TLS2_k127_2054505_20 integral membrane protein - - - 0.00000000000000001768 88.0
TLS2_k127_2054505_21 Pentapeptide repeats (8 copies) - - - 0.00000000000002649 81.0
TLS2_k127_2054505_22 Cupin 2, conserved barrel domain protein - - - 0.0000001379 58.0
TLS2_k127_2054505_23 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000005342 57.0
TLS2_k127_2054505_24 gas vesicle protein - - - 0.0001799 49.0
TLS2_k127_2054505_3 PFAM acyl-CoA dehydrogenase domain protein K00255,K11731 - 1.3.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 507.0
TLS2_k127_2054505_4 PFAM Alpha amylase, catalytic K01176,K01208 GO:0000272,GO:0000287,GO:0001871,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005975,GO:0005976,GO:0005982,GO:0005983,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0016020,GO:0016052,GO:0016160,GO:0016787,GO:0016798,GO:0019867,GO:0030246,GO:0030247,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0046872,GO:0071704,GO:1901575,GO:2001070 3.2.1.1,3.2.1.133,3.2.1.135,3.2.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 503.0
TLS2_k127_2054505_5 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008595 463.0
TLS2_k127_2054505_6 carnitine dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009383 457.0
TLS2_k127_2054505_7 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 365.0
TLS2_k127_2054505_8 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 317.0
TLS2_k127_2054505_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K13774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008953 319.0
TLS2_k127_2056930_0 sensor histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000004004 224.0
TLS2_k127_2056930_1 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000001652 200.0
TLS2_k127_2056930_2 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000004682 209.0
TLS2_k127_2056930_3 Diguanylate cyclase - - - 0.00000000000000000000002668 116.0
TLS2_k127_2064410_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000576 159.0
TLS2_k127_2064410_1 - - - - 0.0002382 50.0
TLS2_k127_2077180_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000007845 213.0
TLS2_k127_2077180_2 CHAT domain - - - 0.000000005001 68.0
TLS2_k127_2082623_0 NAD(P)-binding Rossmann-like domain K00303 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000116 292.0
TLS2_k127_2082623_1 ABC transporter K06147 - - 0.000000000000000000000000000000000000000000000003448 177.0
TLS2_k127_2084662_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.021e-225 711.0
TLS2_k127_2084662_1 Cys/Met metabolism PLP-dependent enzyme K01739,K01758,K01760,K01761 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 513.0
TLS2_k127_2084662_2 Acetyl propionyl-CoA carboxylase, alpha subunit K13777 - 6.4.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 349.0
TLS2_k127_2084662_3 Uncharacterized protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005972 309.0
TLS2_k127_2084662_4 COG0224 F0F1-type ATP synthase gamma subunit K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009875 279.0
TLS2_k127_2084662_5 TIGRFAM YihY family protein (not ribonuclease BN) K07058 - - 0.0000000000000000000000000000000000000000000000000000000000003402 224.0
TLS2_k127_2084662_6 phosphorelay signal transduction system - - - 0.0000000000000000000000000729 115.0
TLS2_k127_2084662_7 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000001903 99.0
TLS2_k127_2084662_8 TIGRFAM Lysine biosynthesis protein LysW K05826 - - 0.00005738 49.0
TLS2_k127_2087636_0 DEAD DEAH box helicase domain protein K06877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 492.0
TLS2_k127_2087636_1 transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 471.0
TLS2_k127_2087636_2 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000001656 193.0
TLS2_k127_2092848_0 Lysine-2,3-aminomutase K01843 - 5.4.3.2 1.168e-217 683.0
TLS2_k127_2092848_1 COG0520 Selenocysteine lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 465.0
TLS2_k127_2092848_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 407.0
TLS2_k127_2092848_3 Homoserine dehydrogenase K00003,K12524 - 1.1.1.3,2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000006714 258.0
TLS2_k127_2092848_4 cellulase activity K01179 - 3.2.1.4 0.000000000000000000000000000002986 137.0
TLS2_k127_2092848_5 Glucose / Sorbosone dehydrogenase - - - 0.00000000000001927 77.0
TLS2_k127_2094651_0 NmrA-like family K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000006541 272.0
TLS2_k127_2094651_1 Belongs to the P(II) protein family - - - 0.00000000000000000000271 98.0
TLS2_k127_2107450_0 Glycosyltransferase Family 4 K15521 - 2.4.1.250 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 527.0
TLS2_k127_2107450_1 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006773 296.0
TLS2_k127_2107450_2 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000134 269.0
TLS2_k127_2107450_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000001573 224.0
TLS2_k127_2107450_5 EamA-like transporter family - - - 0.00000003783 65.0
TLS2_k127_2107450_6 sh3 domain protein K01448,K04771 - 3.4.21.107,3.5.1.28 0.000001013 61.0
TLS2_k127_2113472_0 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 360.0
TLS2_k127_2113472_1 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002442 276.0
TLS2_k127_2113472_2 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000002891 213.0
TLS2_k127_2113472_3 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.0000000000000000000000000000000000000007616 150.0
TLS2_k127_2113472_4 Plasmid pRiA4b ORF-3-like protein - - - 0.00000000000001447 85.0
TLS2_k127_211369_0 Belongs to the UPF0173 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001022 278.0
TLS2_k127_211369_1 Fibronectin type 3 domain - - - 0.00000000000000000000000000000000000001422 157.0
TLS2_k127_2121855_0 Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 549.0
TLS2_k127_2121855_1 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006702 454.0
TLS2_k127_2121855_2 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007272 266.0
TLS2_k127_2121855_3 PFAM oxidoreductase domain protein - - - 0.00000000000000000000000000002383 118.0
TLS2_k127_2148806_0 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 378.0
TLS2_k127_2148806_1 WYL domain K13572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006896 254.0
TLS2_k127_2148806_2 DUF218 domain - - - 0.0000000000000000000000000000000000000000001368 166.0
TLS2_k127_2148806_3 Peptidase dimerisation domain - - - 0.000000000000000245 82.0
TLS2_k127_2155046_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 7.207e-238 768.0
TLS2_k127_2155046_1 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000002716 114.0
TLS2_k127_2160848_0 ABC-type dipeptide transport system, periplasmic component K02035,K12368 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363 - 2.605e-198 631.0
TLS2_k127_2160848_1 PHP domain K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 537.0
TLS2_k127_2160848_2 SMART protein phosphatase 2C domain protein - - - 0.000000000000000000000000000000000000000000000000000000002203 215.0
TLS2_k127_2160848_3 Bacterial SH3 domain - - - 0.00007118 52.0
TLS2_k127_2170837_0 PFAM Homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 3.962e-202 634.0
TLS2_k127_2170837_1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008737 528.0
TLS2_k127_2170837_2 PFAM aminotransferase class I and II K05825 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 411.0
TLS2_k127_2170837_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000001522 204.0
TLS2_k127_2170837_4 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000004946 190.0
TLS2_k127_2170837_5 Polyketide cyclase / dehydrase and lipid transport K09386 - - 0.0000000000000000000000001005 109.0
TLS2_k127_217315_0 intracellular signal transduction - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007814 428.0
TLS2_k127_2176327_0 L-arabinose isomerase activity K01804 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008733,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 5.3.1.4 2.043e-223 702.0
TLS2_k127_2176327_1 Chromate transporter K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006532 480.0
TLS2_k127_2176327_2 peptidase dimerisation domain protein K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008147 432.0
TLS2_k127_2176327_3 Periplasmic binding protein-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 344.0
TLS2_k127_2176327_4 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 313.0
TLS2_k127_2176327_5 McrBC 5-methylcytosine restriction system component K19147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007639 302.0
TLS2_k127_2176327_6 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000004474 232.0
TLS2_k127_2176327_7 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000018 129.0
TLS2_k127_2193265_0 ATPase associated with various cellular activities, AAA_5 K03696 - - 0.0 1034.0
TLS2_k127_2193265_1 Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - 0.00000000000000000000000000000000000000000000000000008117 213.0
TLS2_k127_2193265_2 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.00000000000000000000000000000000006215 155.0
TLS2_k127_2193265_3 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000326 86.0
TLS2_k127_2224021_0 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 501.0
TLS2_k127_2224021_1 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 459.0
TLS2_k127_2224021_10 - - - - 0.0000000000000000000000000000001552 129.0
TLS2_k127_2224021_11 Cupin 2, conserved barrel domain protein K11477 - - 0.0000000000000000000000000001649 117.0
TLS2_k127_2224021_12 - - - - 0.00000000000000000000000007941 115.0
TLS2_k127_2224021_13 rRNA methyltransferase - - - 0.00000000000000000000000164 107.0
TLS2_k127_2224021_14 branched-chain amino acid - - - 0.000000000000000000003341 97.0
TLS2_k127_2224021_15 Domain of unknown function (DUF4166) - - - 0.000000002129 68.0
TLS2_k127_2224021_2 isomerase activity K06998 - 5.3.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006977 386.0
TLS2_k127_2224021_3 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 383.0
TLS2_k127_2224021_4 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 294.0
TLS2_k127_2224021_5 AzlC protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001094 242.0
TLS2_k127_2224021_6 PFAM regulatory protein LuxR - - - 0.00000000000000000000000000000000000000000000000000000000000154 216.0
TLS2_k127_2224021_7 molybdenum ion binding K07140 - - 0.000000000000000000000000000000000000000000000000000000002155 212.0
TLS2_k127_2224021_8 dihydroorotate dehydrogenase activity - - - 0.000000000000000000000000000000000000000002098 168.0
TLS2_k127_2224021_9 Histidine kinase - - - 0.0000000000000000000000000000000002609 150.0
TLS2_k127_222529_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 1.701e-218 696.0
TLS2_k127_222529_1 Fructosamine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 309.0
TLS2_k127_222529_2 PFAM cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000001759 263.0
TLS2_k127_222529_3 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000002372 205.0
TLS2_k127_222529_4 histidine kinase A domain protein - - - 0.0000000000000000000000000008685 128.0
TLS2_k127_222529_5 serine threonine protein kinase - - - 0.0000000000000000008306 95.0
TLS2_k127_222529_6 Serine threonine protein kinase - - - 0.000000000189 70.0
TLS2_k127_2230224_0 Family 4 glycosyl hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 347.0
TLS2_k127_2230224_1 - - - - 0.0000000000000000000000000000000006623 147.0
TLS2_k127_2241689_0 tRNA synthetase, class II (D, K and N) K01893 - 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 441.0
TLS2_k127_2241689_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009021 304.0
TLS2_k127_2241689_2 PFAM ABC transporter related K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000000000000000000000000000001953 242.0
TLS2_k127_2241689_3 PFAM Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000003186 222.0
TLS2_k127_2241689_4 PFAM cytochrome c-type biogenesis protein CcmB K02194 - - 0.000000000000000000000000000001013 131.0
TLS2_k127_2241689_5 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000004355 72.0
TLS2_k127_2241689_7 serine-type endopeptidase activity K04771,K08372 - 3.4.21.107 0.0001822 52.0
TLS2_k127_2269077_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007047 367.0
TLS2_k127_2269077_1 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009465 368.0
TLS2_k127_2269077_2 inorganic phosphate transmembrane transporter activity K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 343.0
TLS2_k127_2269077_3 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 295.0
TLS2_k127_2300189_0 Anaphase-promoting complex subunit 4 WD40 domain - - - 3.402e-302 959.0
TLS2_k127_2300189_1 response regulator K07684 - - 0.0000008675 60.0
TLS2_k127_2300189_2 Cysteine-rich secretory protein family - - - 0.0004591 45.0
TLS2_k127_2308247_0 Integrase core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002422 546.0
TLS2_k127_2308247_1 IstB-like ATP binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002427 275.0
TLS2_k127_2308247_2 PFAM Integrase catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004827 254.0
TLS2_k127_2308247_3 trisaccharide binding - - - 0.0000000001746 66.0
TLS2_k127_2311051_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0 1299.0
TLS2_k127_2311051_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 8.364e-225 720.0
TLS2_k127_2311051_2 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003459 282.0
TLS2_k127_2311051_3 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000006188 166.0
TLS2_k127_2317512_0 Lantibiotic dehydratase, C terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007347 600.0
TLS2_k127_2317512_1 Lanthionine synthetase C-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 384.0
TLS2_k127_2317512_2 Lantibiotic biosynthesis dehydratase C-term - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001821 290.0
TLS2_k127_2317512_3 ABC transporter, ATP-binding protein K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009664 239.0
TLS2_k127_2317512_4 - - - - 0.0000000000000000001679 98.0
TLS2_k127_2337790_0 adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008031 417.0
TLS2_k127_2337790_1 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.000000000000000000000000000000000000000000000000005203 186.0
TLS2_k127_2337790_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000001533 76.0
TLS2_k127_2337790_3 PFAM transglutaminase domain protein - - - 0.0000249 54.0
TLS2_k127_2346594_0 transport system K01992 - - 4.772e-271 864.0
TLS2_k127_2346594_1 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 311.0
TLS2_k127_2346594_2 Predicted membrane protein (DUF2231) - - - 0.000000000000000000000000000000004042 130.0
TLS2_k127_2346594_3 Domain of unknown function (DUF4340) - - - 0.000000000000001972 87.0
TLS2_k127_2347012_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005414 325.0
TLS2_k127_2347012_1 CO dehydrogenase flavoprotein C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004287 285.0
TLS2_k127_2347012_2 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000005717 241.0
TLS2_k127_2347012_3 Beta-galactosidase - - - 0.0000000000000000000000000000002767 137.0
TLS2_k127_2347012_4 Heat shock protein DnaJ domain protein - - - 0.0000003719 61.0
TLS2_k127_2350313_0 serine-type peptidase activity K08676 - - 1.022e-290 914.0
TLS2_k127_2350313_1 transcriptional regulatory protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001618 254.0
TLS2_k127_2350313_3 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000001768 183.0
TLS2_k127_2350313_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000006464 166.0
TLS2_k127_2360102_0 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 467.0
TLS2_k127_2360102_1 PFAM ComEC Rec2-related protein K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007013 443.0
TLS2_k127_2360102_10 HAD-hyrolase-like K07025 - - 0.000000000000000000003727 102.0
TLS2_k127_2360102_11 PFAM SEC-C motif domain protein - - - 0.00000000000000000002733 100.0
TLS2_k127_2360102_12 PFAM RecF RecN SMC - - - 0.00000000000008699 72.0
TLS2_k127_2360102_13 PRC-barrel domain - - - 0.00001877 54.0
TLS2_k127_2360102_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 401.0
TLS2_k127_2360102_3 amino acid-binding ACT domain protein K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 298.0
TLS2_k127_2360102_4 Domain of unknown function (DUF368) K08974 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009417 283.0
TLS2_k127_2360102_5 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000001411 256.0
TLS2_k127_2360102_6 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000007599 221.0
TLS2_k127_2360102_7 NUDIX domain - - - 0.0000000000000000000000000000000000000001195 158.0
TLS2_k127_2360102_8 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000002623 145.0
TLS2_k127_2360102_9 protein kinase activity - - - 0.00000000000000000000000175 107.0
TLS2_k127_2364067_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 513.0
TLS2_k127_2364067_1 PFAM type II secretion system protein E K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003286 457.0
TLS2_k127_2364067_2 PFAM TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007927 274.0
TLS2_k127_2364067_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.00000000000000000000000000000000000000000000000000000000000002832 224.0
TLS2_k127_2364067_4 LppX_LprAFG lipoprotein K14954 - - 0.00000000000000000000003037 109.0
TLS2_k127_2364067_5 Protein conserved in bacteria - GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 - 0.0000000000000006232 91.0
TLS2_k127_2371459_0 protein, phage tail-like region - - - 1.014e-300 960.0
TLS2_k127_2371459_1 protein, phage tail-like region - - - 4.162e-276 875.0
TLS2_k127_2379810_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 501.0
TLS2_k127_2379810_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 311.0
TLS2_k127_2379810_2 PFAM ABC transporter related K09820,K11710 - - 0.00000000000000000000000000000000000000000000000000000000003573 211.0
TLS2_k127_2379810_3 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000127 188.0
TLS2_k127_2379810_4 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000005063 169.0
TLS2_k127_2379810_5 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000538 94.0
TLS2_k127_2379810_6 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000001073 91.0
TLS2_k127_2379810_7 Belongs to the bacterial ribosomal protein bL33 family K02913 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000006062 78.0
TLS2_k127_2379810_8 tetratricopeptide repeat - - - 0.0000001063 63.0
TLS2_k127_2382752_0 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 398.0
TLS2_k127_2382752_1 metal-dependent phosphohydrolase, HD sub domain K07037 - - 0.0000000000000000000000000000000000000000000000000000000001715 222.0
TLS2_k127_2382752_2 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000000000000000001068 195.0
TLS2_k127_2382752_3 Yqey-like protein K09117 - - 0.000000000000000000000000000000002014 134.0
TLS2_k127_2399016_0 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 482.0
TLS2_k127_2400061_0 PFAM amine oxidase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 1.819e-240 751.0
TLS2_k127_2400061_1 PFAM Cytochrome P450 - GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016125,GO:0016491,GO:0030312,GO:0044238,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901615 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 518.0
TLS2_k127_2400061_2 SMART PUA domain containing protein K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 415.0
TLS2_k127_2400061_3 PFAM Squalene phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 344.0
TLS2_k127_2400061_4 PFAM Glycosyl transferase family 2 K14597 - - 0.000000000000000000000000000000000000000001414 170.0
TLS2_k127_2401924_0 Sucrose phosphorylase K00690,K21350 - 2.4.1.329,2.4.1.7 2.812e-195 624.0
TLS2_k127_2401924_1 ATPase MipZ K03496 - - 0.00000000000000000000000000006718 128.0
TLS2_k127_2401924_3 PFAM Glycosyl transferases group 1 - - - 0.0009163 43.0
TLS2_k127_2404343_0 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.00000000000000000000000000000000000000000000007442 171.0
TLS2_k127_2404343_1 DNA helicase - - - 0.00000000000000000000000000000000000000000001039 172.0
TLS2_k127_2404343_2 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000000000000000505 134.0
TLS2_k127_2404343_3 Cytochrome c K17222 - - 0.00000000000000000000000000001582 129.0
TLS2_k127_2404343_4 Transcriptional regulator - - - 0.000000000000004509 77.0
TLS2_k127_2413848_0 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006916 349.0
TLS2_k127_2413848_1 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000001414 213.0
TLS2_k127_2413848_2 sh3 domain protein K01227,K03642 - 3.2.1.96 0.00000000000000000000000000000000000003202 165.0
TLS2_k127_2413848_3 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000206 144.0
TLS2_k127_2415642_0 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 345.0
TLS2_k127_2415642_1 Belongs to the 'phage' integrase family K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 292.0
TLS2_k127_2415642_2 Methyltransferase K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000144 192.0
TLS2_k127_2415642_3 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000004737 125.0
TLS2_k127_2415642_4 UTP--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000004438 71.0
TLS2_k127_2415642_5 PFAM glycosyl transferase, family 51 - - - 0.0000932 53.0
TLS2_k127_2418096_0 Glycoside hydrolase family 16 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 446.0
TLS2_k127_2418096_1 COG1609 Transcriptional regulators K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009348 352.0
TLS2_k127_2418096_2 Histidine kinase - - - 0.000000003394 63.0
TLS2_k127_2421508_0 Belongs to the GcvT family - - - 2.459e-196 620.0
TLS2_k127_2421508_1 trimethylamine methyltransferase K14083 - 2.1.1.250 6.502e-195 620.0
TLS2_k127_2421508_2 KAP family P-loop domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 482.0
TLS2_k127_2421508_3 Semialdehyde dehydrogenase, NAD binding domain K00133,K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0030312,GO:0036094,GO:0040007,GO:0043891,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071944,GO:0097159,GO:1901265,GO:1901363 1.2.1.11,1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 387.0
TLS2_k127_2421508_4 gntR family - - - 0.0000000000000000000000000000000000000001324 161.0
TLS2_k127_2421508_5 Bacterial regulatory proteins, tetR family - - - 0.0000000000003319 74.0
TLS2_k127_2422431_0 ATPase activity K02045 - 3.6.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 463.0
TLS2_k127_2422431_1 transmembrane transporter activity K05820 - - 0.000000000000000000000000000000000000000000000000000000000000000007579 241.0
TLS2_k127_2422431_2 Sulfate ABC transporter substrate-binding protein K02048 - - 0.000000000000000000000000000000000000000000000000000002181 205.0
TLS2_k127_2422431_3 sulfate ABC transporter K02046 - - 0.00000000000000000000000000000000000000000000000000001369 199.0
TLS2_k127_2422431_4 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000007216 157.0
TLS2_k127_2422431_5 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000002942 126.0
TLS2_k127_2422431_6 alcohol dehydrogenase - - - 0.0000000000000004392 85.0
TLS2_k127_245969_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 0.0 1213.0
TLS2_k127_245969_1 Threonyl alanyl tRNA synthetase SAD K07050 - - 0.0000000000000000000000000000000000003436 141.0
TLS2_k127_2462131_0 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 353.0
TLS2_k127_2462131_1 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009009 329.0
TLS2_k127_2462131_10 Dna alkylation repair - - - 0.00000000000838 68.0
TLS2_k127_2462131_2 PFAM DSBA oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001393 297.0
TLS2_k127_2462131_3 PFAM Uncharacterised protein family UPF0066 K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000001122 187.0
TLS2_k127_2462131_4 DinB family - - - 0.000000000000000000000000000000000000000000000000002248 188.0
TLS2_k127_2462131_5 - K13652 - - 0.000000000000000000000000000000000000000000003364 168.0
TLS2_k127_2462131_6 NUDIX domain - - - 0.00000000000000000000000000000000000001101 152.0
TLS2_k127_2462131_7 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000003685 145.0
TLS2_k127_2462131_8 ErfK ybiS ycfS ynhG family protein - - - 0.00000000000000000004384 100.0
TLS2_k127_2462131_9 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.000000000000002222 87.0
TLS2_k127_2473587_0 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 297.0
TLS2_k127_2473587_1 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000001362 212.0
TLS2_k127_2473587_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000001496 161.0
TLS2_k127_2473587_3 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.0000000000000000000000000000000000004049 143.0
TLS2_k127_2476133_0 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 392.0
TLS2_k127_2476133_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005494 384.0
TLS2_k127_2476133_2 COG1226 Kef-type K transport systems K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008742 288.0
TLS2_k127_2476133_3 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002053 276.0
TLS2_k127_2476133_4 regulator - - - 0.000000000000000000001981 107.0
TLS2_k127_2476133_5 Protein of unknown function (DUF3592) - - - 0.0001528 51.0
TLS2_k127_2496596_0 intracellular signal transduction - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000871 403.0
TLS2_k127_2498961_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 372.0
TLS2_k127_2498961_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004123 317.0
TLS2_k127_2500955_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 6.429e-269 854.0
TLS2_k127_2500955_1 Penicillin amidase K01434 - 3.5.1.11 5.263e-219 705.0
TLS2_k127_2500955_10 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000000000001658 156.0
TLS2_k127_2500955_11 Protein of unknown function (DUF998) - - - 0.00000000000000000000001291 104.0
TLS2_k127_2500955_12 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000007215 98.0
TLS2_k127_2500955_13 peptidase A24A prepilin type IV K02654 - 3.4.23.43 0.0000000001783 70.0
TLS2_k127_2500955_2 Spore coat protein CotH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000695 500.0
TLS2_k127_2500955_3 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 366.0
TLS2_k127_2500955_4 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 342.0
TLS2_k127_2500955_5 endonuclease III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007549 312.0
TLS2_k127_2500955_6 NmrA-like family K19267 - 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006726 308.0
TLS2_k127_2500955_7 XdhC Rossmann domain K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000797 301.0
TLS2_k127_2500955_8 Domain of unknown function (DUF4956) - - - 0.0000000000000000000000000000000000000000000000000000000000000000007953 235.0
TLS2_k127_2500955_9 VTC domain - - - 0.0000000000000000000000000000000000000000000000000000000006437 212.0
TLS2_k127_2530746_0 Evidence 5 No homology to any previously reported sequences K07156,K07245,K14166 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000006985 271.0
TLS2_k127_2530746_1 - - - - 0.000000000001216 76.0
TLS2_k127_2530746_2 - - - - 0.0002804 50.0
TLS2_k127_2576244_0 Altronate hydrolase K01685,K01708 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0008789,GO:0008867,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019577,GO:0019579,GO:0019580,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046392,GO:0046395,GO:0046396,GO:0046397,GO:0071704,GO:0072329,GO:1901575 4.2.1.42,4.2.1.7 2.123e-211 676.0
TLS2_k127_2576244_1 Glycoside hydrolase family 44 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004039 607.0
TLS2_k127_2576244_2 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 376.0
TLS2_k127_2576244_3 serine-type peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 376.0
TLS2_k127_258401_0 D-arabinono-1,4-lactone oxidase - - - 0.000000000000000000000000000000000001506 141.0
TLS2_k127_258401_1 Beta-L-arabinofuranosidase, GH127 - - - 0.00000000000000000000000000000000003879 137.0
TLS2_k127_258401_2 TfoX N-terminal domain K07343 - - 0.0000000000000000000000000001389 121.0
TLS2_k127_2584541_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 364.0
TLS2_k127_2584541_1 sigma-70 region 2 domain protein K03088 - - 0.00000000000000000000000000000000000000000000000000000044 199.0
TLS2_k127_2584541_3 ADP-ribose pyrophosphatase - - - 0.00000000152 60.0
TLS2_k127_2584541_4 MOSC domain - - - 0.0000000533 54.0
TLS2_k127_2584541_5 - - - - 0.0000004734 52.0
TLS2_k127_2584541_6 AntiSigma factor - - - 0.0001337 53.0
TLS2_k127_2598147_0 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 1.234e-277 867.0
TLS2_k127_2598147_1 PFAM RNA recognition motif - - - 0.0000000000000000000000000001626 120.0
TLS2_k127_2598147_2 AI-2E family transporter - - - 0.0001145 54.0
TLS2_k127_260003_0 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 522.0
TLS2_k127_260003_1 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 362.0
TLS2_k127_260003_2 toxin-antitoxin pair type II binding - - - 0.000000006378 60.0
TLS2_k127_260003_3 PIN domain - - - 0.00007344 45.0
TLS2_k127_2600168_0 PFAM phenylalanine histidine ammonia-lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 607.0
TLS2_k127_2600168_1 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000001081 227.0
TLS2_k127_2600168_2 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000004733 172.0
TLS2_k127_2600168_3 Domain of unknown function (DUF4260) - - - 0.000000000000001163 77.0
TLS2_k127_2601391_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 1.378e-230 736.0
TLS2_k127_2601391_1 udp-glucose 4-epimerase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000424 521.0
TLS2_k127_2601391_10 PQQ enzyme repeat - - - 0.0000000000000000000000000000000000113 149.0
TLS2_k127_2601391_2 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system K10562 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 483.0
TLS2_k127_2601391_3 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 461.0
TLS2_k127_2601391_4 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 358.0
TLS2_k127_2601391_5 ATPases associated with a variety of cellular activities K10545 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 349.0
TLS2_k127_2601391_6 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003486 253.0
TLS2_k127_2601391_7 PFAM periplasmic binding protein LacI transcriptional regulator K10439 - - 0.00000000000000000000000000000000000000000004621 172.0
TLS2_k127_2601391_8 PFAM single-stranded nucleic acid binding R3H domain protein K06346 - - 0.0000000000000000000000000000000000002722 148.0
TLS2_k127_2601391_9 PFAM 60 kDa inner membrane insertion protein K03217 - - 0.000000000000000000000000000000000006057 148.0
TLS2_k127_2620417_0 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 338.0
TLS2_k127_2620417_1 CoA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 323.0
TLS2_k127_2645102_0 Nitrous oxide reductase K00376 - 1.7.2.4 1.564e-299 930.0
TLS2_k127_2645102_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000002962 262.0
TLS2_k127_2645102_2 lipoprotein involved in nitrous oxide reduction K19342 - - 0.0000000000000000000000000000000000000000000000000000000002795 209.0
TLS2_k127_2645102_3 Crp Fnr family K21564 - - 0.000000000000000000000000000000000000000000000000000000008308 206.0
TLS2_k127_2645102_4 (Rhomboid) family - - - 0.000000000000000000000000000004063 126.0
TLS2_k127_2645102_5 Electron transfer flavoprotein K03521 - - 0.0000000000000000005264 89.0
TLS2_k127_264858_0 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 4.338e-249 785.0
TLS2_k127_264858_1 metallopeptidase activity K03634,K14166 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 340.0
TLS2_k127_264858_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058,K16843 - 1.1.1.310,1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000001198 282.0
TLS2_k127_264858_3 Serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000004604 177.0
TLS2_k127_264858_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000007979 149.0
TLS2_k127_264858_5 Psort location CytoplasmicMembrane, score K00368 - 1.7.2.1 0.00000000000000000000000000000000000006002 166.0
TLS2_k127_264858_6 - - - - 0.00000000000000000000006955 104.0
TLS2_k127_264858_7 alginic acid biosynthetic process K09483 - 4.2.1.118 0.00000000000000000000706 109.0
TLS2_k127_264858_8 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000001056 76.0
TLS2_k127_2670140_0 FGGY family of carbohydrate kinases, N-terminal domain K00853 - 2.7.1.16 1.458e-227 715.0
TLS2_k127_2671367_0 Transcriptional regulator K02529,K07506 - - 7.385e-310 985.0
TLS2_k127_2671367_1 Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - 0.0000000000000000000000000000000001588 140.0
TLS2_k127_2677552_0 Hydroxymethylglutaryl-CoA lyase K01640,K18314 - 4.1.3.4,4.1.3.46 0.00000000000000000000000000000000000000000000000000000000000000000000000009233 259.0
TLS2_k127_2677552_1 - - - - 0.0000000000000000000000000000000000000000002051 163.0
TLS2_k127_2677552_2 Histidine kinase - - - 0.0000000000000000000000000000000000003158 153.0
TLS2_k127_2677552_3 Protein of unknown function (DUF423) - - - 0.00000000000000000000000000000002231 130.0
TLS2_k127_2677552_4 Involved in the tonB-independent uptake of proteins K03641 - - 0.00000000000000000000000000003403 131.0
TLS2_k127_2677552_5 PFAM Rhodanese-like domain - - - 0.00000000000000000001232 95.0
TLS2_k127_2702733_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 4.272e-225 710.0
TLS2_k127_2702733_1 SMART phosphoesterase PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000009563 237.0
TLS2_k127_2702733_2 OsmC-like protein K07397 - - 0.00000000000000000000000000000000000000000000000000000004472 199.0
TLS2_k127_2702733_3 TIGRFAM molybdenum cofactor synthesis domain - - - 0.000000000000000000000000000000000000000000000000000007603 193.0
TLS2_k127_2703335_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007961 383.0
TLS2_k127_2703335_1 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 290.0
TLS2_k127_2703335_2 WD40 repeats - - - 0.000000000000000000000187 115.0
TLS2_k127_2710739_0 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000005895 125.0
TLS2_k127_2710739_1 - - - - 0.000000000804 61.0
TLS2_k127_2713685_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1140.0
TLS2_k127_2713685_1 PFAM bifunctional deaminase-reductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 297.0
TLS2_k127_2713685_2 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001573 248.0
TLS2_k127_2713685_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000001137 123.0
TLS2_k127_2713685_4 - - - - 0.000000003503 60.0
TLS2_k127_2733718_0 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 354.0
TLS2_k127_2733718_1 PFAM Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000275 198.0
TLS2_k127_2738310_0 protein histidine kinase activity K01768,K11527,K18143 - 2.7.13.3,4.6.1.1 0.0000000000000000000000000000000000000000000000001147 202.0
TLS2_k127_2738310_1 protein histidine kinase activity K01768,K11527,K18143 - 2.7.13.3,4.6.1.1 0.0000000000000000000000000000000000000000000000001219 204.0
TLS2_k127_2738310_2 Signal Transduction Histidine Kinase - - - 0.0000000000000000005604 103.0
TLS2_k127_2740136_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 445.0
TLS2_k127_2740136_1 WD40-like Beta Propeller Repeat K03641 - - 0.000000000000000000000000000000000000000000006252 178.0
TLS2_k127_2740136_2 PFAM RNP-1 like RNA-binding protein - - - 0.00000000000000000000000007346 113.0
TLS2_k127_2746225_0 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 381.0
TLS2_k127_2746225_1 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000004016 170.0
TLS2_k127_2751788_0 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K08070 - 1.3.1.74,3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 310.0
TLS2_k127_2751788_1 Family of unknown function (DUF1028) - - - 0.000000000000000000000000000000000000000000000000000000000000000001975 233.0
TLS2_k127_2786777_0 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 1.193e-216 681.0
TLS2_k127_2786777_1 Histidine kinase K00936,K01719,K01768,K02030,K02584,K10441,K13924,K20962 - 2.1.1.80,2.7.13.3,3.1.1.61,3.1.4.52,3.6.3.17,4.2.1.75,4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 353.0
TLS2_k127_2786777_2 Glutamine synthetase, catalytic region K01915 - 6.3.1.2 0.000000000000001015 78.0
TLS2_k127_2795938_0 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 341.0
TLS2_k127_2795938_1 ATPase, P-type transporting, HAD superfamily, subfamily IC K16905 - - 0.000000000000000000000000000000000000000000000000000000000000000009505 237.0
TLS2_k127_2795938_2 transmembrane transport K16906 - - 0.0000000000000000000000000000000000000000000000000007104 193.0
TLS2_k127_2795938_3 ABC-type Na efflux pump, permease K01992 - - 0.0000000000000000000000000000000000000000006929 167.0
TLS2_k127_2795938_4 Putative membrane peptidase family (DUF2324) - - - 0.000000000000000000000000000000000000000000875 168.0
TLS2_k127_2795938_5 PFAM peptidase S58 DmpA - - - 0.0000000000000000000000000000000005569 134.0
TLS2_k127_2795938_6 COG1131 ABC-type multidrug transport system ATPase component K16907 - - 0.000000000000000000000000001017 113.0
TLS2_k127_2808566_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02484,K07642 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 434.0
TLS2_k127_2808566_1 ATPases associated with a variety of cellular activities K02006,K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 342.0
TLS2_k127_2808566_2 Two component transcriptional regulator, winged helix family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006488 324.0
TLS2_k127_2808566_3 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 324.0
TLS2_k127_2808566_4 Ferric uptake regulator family K03711 - - 0.000000000000000000000000008162 114.0
TLS2_k127_2808566_5 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000002642 88.0
TLS2_k127_2813732_0 short-chain dehydrogenase reductase SDR K12454 - 5.1.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006204 431.0
TLS2_k127_2813732_1 PFAM peptidase M22 glycoprotease K14742 - - 0.000000000000000000000000000000000008651 144.0
TLS2_k127_2813732_2 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.0000000000000000000000000000002281 130.0
TLS2_k127_2813732_3 PD-(D/E)XK nuclease superfamily - - - 0.000000000504 67.0
TLS2_k127_2813732_4 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000001528 55.0
TLS2_k127_2814699_0 TIGRFAM methylmalonyl-CoA mutase, large subunit K01847,K01848 - 5.4.99.2 7.226e-245 767.0
TLS2_k127_2814699_1 L-malate dehydrogenase activity K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0030312,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008486 390.0
TLS2_k127_2814699_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000000000000000000000000000001545 162.0
TLS2_k127_2817962_0 PFAM alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 477.0
TLS2_k127_2817962_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000008475 241.0
TLS2_k127_2817962_2 Transcriptional regulatory protein, C terminal K07667 - - 0.000000000000000000000000000000000000000000000000000006065 198.0
TLS2_k127_2817962_3 nucleic acid-binding protein contains PIN domain K07062 - - 0.00000000000000000000000000000000000000204 149.0
TLS2_k127_2817962_4 domain protein K12516 - - 0.0000000000000000000000000000005687 133.0
TLS2_k127_2817962_5 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.000000000000000000000000007213 114.0
TLS2_k127_2821752_0 ribonucleoside-diphosphate reductase activity K00525,K21636 - 1.1.98.6,1.17.4.1 6.86e-307 981.0
TLS2_k127_2821752_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 458.0
TLS2_k127_2821752_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 420.0
TLS2_k127_2821752_3 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 396.0
TLS2_k127_2821752_4 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K01083,K06131,K06915 - 3.1.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 336.0
TLS2_k127_2821752_5 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000056 199.0
TLS2_k127_2821752_6 POTRA domain, FtsQ-type K01921,K03589 GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 6.3.2.4 0.0000000000005984 79.0
TLS2_k127_2829753_0 PFAM Transketolase central region K00162,K11381,K21417 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 440.0
TLS2_k127_2829753_1 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004783 400.0
TLS2_k127_2829753_10 Two component transcriptional regulator, winged helix family K07657 - - 0.000000000000000000000000000000000000000000000000000000171 202.0
TLS2_k127_2829753_11 COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase - - - 0.000000000000000000000000000000000000000000000002856 189.0
TLS2_k127_2829753_12 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 - - - 0.0000000000000001813 91.0
TLS2_k127_2829753_13 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000000107 66.0
TLS2_k127_2829753_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 369.0
TLS2_k127_2829753_3 Catalytic domain of components of various dehydrogenase complexes K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 362.0
TLS2_k127_2829753_4 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 328.0
TLS2_k127_2829753_5 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009149 308.0
TLS2_k127_2829753_6 histidine kinase A domain protein K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001582 282.0
TLS2_k127_2829753_7 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000001617 256.0
TLS2_k127_2829753_8 PFAM metal-dependent phosphohydrolase, HD sub domain K02103,K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002208 273.0
TLS2_k127_2829753_9 Purine catabolism regulatory protein-like family K09684 - - 0.000000000000000000000000000000000000000000000000000000000002088 229.0
TLS2_k127_2829942_0 Protein of unknown function (DUF4058) - - - 0.0000000000000000000000000000000007897 134.0
TLS2_k127_2829942_1 PFAM Nucleotidyltransferase domain K07075 - - 0.0000000000000000000000000000172 120.0
TLS2_k127_2829942_2 Protein of unknown function DUF86 - - - 0.00000000000000000000000000002343 121.0
TLS2_k127_2829942_3 Aminoacyl-tRNA editing domain - - - 0.000000000000000000005429 93.0
TLS2_k127_2829942_4 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000003851 67.0
TLS2_k127_2829942_5 oxidoreductase activity K08282,K16260 - 2.7.11.1 0.0000000006704 70.0
TLS2_k127_2836618_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01534 - 3.6.3.3,3.6.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007519 478.0
TLS2_k127_2836618_1 PFAM ABC transporter related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 361.0
TLS2_k127_2836618_2 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002235 266.0
TLS2_k127_2836618_3 Transcriptional regulator K19591 - - 0.0000000000000625 81.0
TLS2_k127_2847081_0 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000003605 224.0
TLS2_k127_2854515_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 9.466e-282 889.0
TLS2_k127_2854515_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 572.0
TLS2_k127_2854515_2 Pyridoxal-phosphate dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000228 203.0
TLS2_k127_2854515_3 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000002117 196.0
TLS2_k127_2854515_4 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.000000000000000000000000000000000005287 140.0
TLS2_k127_2854515_5 N-terminal double-glycine peptidase domain K06147 - - 0.00003399 52.0
TLS2_k127_2871789_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00122,K00335 - 1.17.1.9,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 511.0
TLS2_k127_2871789_1 ATP-grasp domain K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 446.0
TLS2_k127_2871789_2 formate dehydrogenase (NAD+) activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 292.0
TLS2_k127_2871789_3 Formyl transferase K00604,K11175 - 2.1.2.2,2.1.2.9 0.0000000000000000000000000000000000000000000000000000000002799 214.0
TLS2_k127_2871789_4 - - - - 0.000000000000000000000000000000000000000000008755 171.0
TLS2_k127_2871789_5 Bacterial Fe(2+) trafficking - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887 - 0.000000000000000000000000000000000042 136.0
TLS2_k127_2871789_6 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000000000000000000009819 126.0
TLS2_k127_2871789_7 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000000004952 94.0
TLS2_k127_2871789_8 PFAM YcfA-like protein - - - 0.0000000000000000026 85.0
TLS2_k127_2871789_9 Cupin domain protein - - - 0.0000008334 55.0
TLS2_k127_2878967_0 Belongs to the formate--tetrahydrofolate ligase family K00288,K01938 GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.5.1.5,3.5.4.9,6.3.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000002132 250.0
TLS2_k127_2878967_2 RDD family - - - 0.0000000000000000000000000000007277 129.0
TLS2_k127_2878967_3 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000984 91.0
TLS2_k127_2878967_4 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000004237 65.0
TLS2_k127_2878967_5 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000005367 66.0
TLS2_k127_2878967_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00002425 57.0
TLS2_k127_2878967_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0001276 55.0
TLS2_k127_287983_0 Sulfate transporter antisigma-factor antagonist STAS K03321 - - 4.816e-200 647.0
TLS2_k127_287983_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 548.0
TLS2_k127_287983_10 DNA binding - - - 0.000000000000000001094 94.0
TLS2_k127_287983_2 purine nucleotide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 364.0
TLS2_k127_287983_3 intracellular signal transduction - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005806 390.0
TLS2_k127_287983_4 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 334.0
TLS2_k127_287983_5 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000444 338.0
TLS2_k127_287983_6 Transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000008297 259.0
TLS2_k127_287983_7 cellulase activity - - - 0.0000000000000000000000000000000000000000000000000000001149 216.0
TLS2_k127_287983_8 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.0000000000000000000000000000000000000000000004612 194.0
TLS2_k127_287983_9 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000004838 153.0
TLS2_k127_288117_0 mannose-6-phosphate isomerase - - - 0.00000000000000000000000000000000000000000000000000000001375 200.0
TLS2_k127_288117_1 Protein of unknown function (DUF421) - - - 0.00000000000000000000000000000000000000000000000000003518 195.0
TLS2_k127_288117_2 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000001178 196.0
TLS2_k127_288117_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000557 181.0
TLS2_k127_288117_4 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000000000002163 155.0
TLS2_k127_288117_5 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000009567 144.0
TLS2_k127_288117_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000001815 146.0
TLS2_k127_288117_7 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000003866 83.0
TLS2_k127_288117_8 membrane - - - 0.000003752 49.0
TLS2_k127_288117_9 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000202 58.0
TLS2_k127_2886424_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 435.0
TLS2_k127_2886424_1 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 396.0
TLS2_k127_2886424_2 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 393.0
TLS2_k127_2886424_3 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006661 296.0
TLS2_k127_2886424_4 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000001492 183.0
TLS2_k127_2886424_5 - - - - 0.00000000000000000000000000004695 125.0
TLS2_k127_2886424_6 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000229 65.0
TLS2_k127_2889936_0 PFAM DNA mismatch repair protein MutS domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 493.0
TLS2_k127_2889936_1 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 328.0
TLS2_k127_2889936_2 TIGRFAM small GTP-binding protein K06945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 288.0
TLS2_k127_2889936_3 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 287.0
TLS2_k127_2889936_4 PFAM alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000009024 239.0
TLS2_k127_2889936_5 4-vinyl reductase, 4VR - - - 0.00000000000000000000000000000000000000000000000000000000001392 213.0
TLS2_k127_2889936_6 Hexapeptide repeat of succinyl-transferase - - - 0.00000000000000000005189 91.0
TLS2_k127_2900618_0 PFAM Forkhead-associated protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 361.0
TLS2_k127_2900618_1 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 302.0
TLS2_k127_2900618_2 META domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001016 269.0
TLS2_k127_2900618_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000003206 143.0
TLS2_k127_2900618_4 Psort location CytoplasmicMembrane, score K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.00000000000000006463 96.0
TLS2_k127_2900618_5 helix_turn_helix, Lux Regulon - - - 0.000000000000006341 83.0
TLS2_k127_2900618_6 helix_turn_helix, Lux Regulon - - - 0.00000000000001354 83.0
TLS2_k127_2900825_0 Polynucleotide adenylyltransferase region K00974 - 2.7.7.72 2.856e-203 662.0
TLS2_k127_2900825_2 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.0000000000000853 80.0
TLS2_k127_2902613_0 ATPase activity K14338 - 1.14.14.1,1.6.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 499.0
TLS2_k127_2902613_1 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 293.0
TLS2_k127_2902613_2 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000007851 235.0
TLS2_k127_2902613_3 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000003864 197.0
TLS2_k127_2902613_4 PFAM glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000001689 161.0
TLS2_k127_2902613_5 IMP dehydrogenase activity K06041,K11527 - 2.7.13.3,5.3.1.13 0.000000000000000000000000000000007149 140.0
TLS2_k127_2902613_6 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000006836 128.0
TLS2_k127_2902613_7 Domain of unknown function (DUF4870) - - - 0.0000000000000000000000000002296 118.0
TLS2_k127_2902613_8 Protein of unknown function (DUF4013) - - - 0.000000000000000000000008801 110.0
TLS2_k127_2906333_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 591.0
TLS2_k127_2906333_1 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 303.0
TLS2_k127_2906333_2 isochorismatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 293.0
TLS2_k127_2906333_3 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000008312 245.0
TLS2_k127_2906333_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000007557 182.0
TLS2_k127_2906333_5 SMART PAS domain containing protein - - - 0.000000000000000000000000000000000001571 156.0
TLS2_k127_2906333_6 RNA polymerase K03088 - - 0.0000000000000000000000000009404 121.0
TLS2_k127_2906333_7 - - - - 0.000000000000000127 89.0
TLS2_k127_2911070_0 TIGRFAM MazG family protein K02499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 440.0
TLS2_k127_2911070_1 Putative transposase DNA-binding domain K07496 - - 0.0000001749 55.0
TLS2_k127_2921107_0 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000046 359.0
TLS2_k127_2921107_1 - K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 321.0
TLS2_k127_2921107_2 PFAM Exonuclease, RNase T and DNA polymerase III K02342,K03722 - 2.7.7.7,3.6.4.12 0.000000000000000000000000000000000000000000000008574 181.0
TLS2_k127_2921107_3 NurA - - - 0.000000000000000000000000000000000000000634 163.0
TLS2_k127_2921107_5 Belongs to the GbsR family - - - 0.00000000000000000002016 98.0
TLS2_k127_2934566_0 PFAM ABC transporter transmembrane region K06147 - - 2.158e-212 676.0
TLS2_k127_2934566_1 Isocitrate dehydrogenase K00031 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006139 569.0
TLS2_k127_2934566_2 PFAM Phosphomethylpyrimidine kinase type-1 K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000005372 222.0
TLS2_k127_2934566_3 Methyltransferase domain - - - 0.0000000000000000000000006904 113.0
TLS2_k127_2934566_4 PIN domain - - - 0.0000000000000000000003419 102.0
TLS2_k127_2941097_0 - - - - 6.066e-256 808.0
TLS2_k127_2941097_1 Serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000001378 189.0
TLS2_k127_2941097_2 glyoxalase III activity - - - 0.0000000000000000000000000003233 116.0
TLS2_k127_2942018_0 Selenocysteine-specific translation elongation factor K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 615.0
TLS2_k127_2942018_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009437 482.0
TLS2_k127_2942018_2 Right handed beta helix region - - - 0.000008747 56.0
TLS2_k127_2942172_0 ABC transporter transmembrane region K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 612.0
TLS2_k127_2942172_1 NB-ARC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008607 497.0
TLS2_k127_2945664_0 Branched-chain amino acid aminotransferase K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008801 436.0
TLS2_k127_2945664_1 COG0569 K transport systems, NAD-binding component K03499 - - 0.000000000000009713 76.0
TLS2_k127_2945664_2 Ig-like domain from next to BRCA1 gene K17987 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005770,GO:0005773,GO:0005829,GO:0006914,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0012505,GO:0016043,GO:0016236,GO:0022607,GO:0031410,GO:0031982,GO:0032182,GO:0034622,GO:0043130,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0051258,GO:0051259,GO:0061919,GO:0065003,GO:0071840,GO:0097708 - 0.000000000001742 81.0
TLS2_k127_2945664_3 PFAM Abortive infection protein K07052 - - 0.000007945 55.0
TLS2_k127_295371_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 2.353e-276 895.0
TLS2_k127_295371_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 397.0
TLS2_k127_295371_2 TIGRFAM LAO AO transport system ATPase K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008595 302.0
TLS2_k127_295371_3 His Kinase A (phosphoacceptor) domain - - - 0.00000002965 65.0
TLS2_k127_2959549_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 3.678e-267 842.0
TLS2_k127_2959549_1 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005723 500.0
TLS2_k127_2959549_2 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 366.0
TLS2_k127_2959549_3 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.0000000000000000000000000000000000000000000000000000000001879 220.0
TLS2_k127_2959549_4 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000001326 154.0
TLS2_k127_2959549_5 CO dehydrogenase flavoprotein C-terminal domain - - - 0.00000000000000000000000000000002183 127.0
TLS2_k127_2959549_6 PFAM glycosyl transferase family 39 - - - 0.0000000002236 75.0
TLS2_k127_2959549_7 LysM domain - - - 0.00004033 56.0
TLS2_k127_2965374_0 Alpha-amylase domain K01187,K05341,K05343 - 2.4.1.4,3.2.1.1,3.2.1.20,5.4.99.16 2.218e-214 681.0
TLS2_k127_2969705_0 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005613 425.0
TLS2_k127_2969705_1 PFAM Enoyl-CoA hydratase isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 307.0
TLS2_k127_2969705_2 Domain of unknown function (DUF427) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002228 247.0
TLS2_k127_2969705_3 oligosaccharyl transferase activity - - - 0.00000000000000000000000000000000000000000000000000003635 213.0
TLS2_k127_2969705_4 DNA-binding transcription factor activity K04761 - - 0.0000000000000000000000009449 115.0
TLS2_k127_2969705_5 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000004114 107.0
TLS2_k127_2982812_0 NAD(P)H-binding K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 375.0
TLS2_k127_2982812_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000325 351.0
TLS2_k127_2982812_2 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 288.0
TLS2_k127_2982812_3 PFAM Tetratricopeptide repeat - - - 0.0000002308 58.0
TLS2_k127_3000144_0 ABC-type sugar transport system periplasmic component K02058,K10559 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 479.0
TLS2_k127_3000144_1 Belongs to the binding-protein-dependent transport system permease family K10561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 455.0
TLS2_k127_3000144_2 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 422.0
TLS2_k127_3000144_3 Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system K17215 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 301.0
TLS2_k127_3000144_4 rhamnose metabolic process K03534 - 5.1.3.32 0.00000000000000000000000000000000000000000000002499 172.0
TLS2_k127_3002281_0 PFAM glycosyl transferase, family 51 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 616.0
TLS2_k127_3002281_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009347 383.0
TLS2_k127_3002281_2 MaoC like domain - - - 0.0000000000000000000000000000000000000000000001745 171.0
TLS2_k127_3002281_3 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000004318 177.0
TLS2_k127_3002281_4 DJ-1/PfpI family K03152 - 3.5.1.124 0.00001069 55.0
TLS2_k127_3010449_0 self proteolysis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 403.0
TLS2_k127_3012560_0 Cellobiose phosphorylase K00702,K13688,K18675 - 2.4.1.20,2.4.1.280 0.0 1562.0
TLS2_k127_3012560_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000002553 170.0
TLS2_k127_3012560_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000001996 141.0
TLS2_k127_3012560_3 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000001312 145.0
TLS2_k127_3012560_5 - - - - 0.0000000000000001758 87.0
TLS2_k127_3012560_6 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000000000001929 82.0
TLS2_k127_3033695_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000009496 190.0
TLS2_k127_3033695_2 repeat protein - - - 0.000003399 61.0
TLS2_k127_3045645_0 transferase activity, transferring glycosyl groups K16148 - 2.4.1.342 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 337.0
TLS2_k127_3045645_1 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 333.0
TLS2_k127_3045645_2 PFAM polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000001656 193.0
TLS2_k127_3048666_0 Amidinotransferase K01478 - 3.5.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 553.0
TLS2_k127_3048666_1 Domain of unknown function (DUF1998) K06877 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 329.0
TLS2_k127_3048666_2 DNA binding - - - 0.000000005986 59.0
TLS2_k127_304979_0 self proteolysis - - - 0.00000000000000000000000000000001748 145.0
TLS2_k127_3050233_0 Glucose / Sorbosone dehydrogenase K21430 - - 4.551e-222 733.0
TLS2_k127_3050233_1 Glyco_18 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 295.0
TLS2_k127_3050233_2 G8 - - - 0.00000000000000000000000000000000000002067 168.0
TLS2_k127_3050233_3 Methyltransferase type 12 - - - 0.0000000000000000000000000000000000006383 150.0
TLS2_k127_3050233_4 Pkd domain containing protein - - - 0.000000001102 73.0
TLS2_k127_3065902_0 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005882 454.0
TLS2_k127_3065902_1 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008829 431.0
TLS2_k127_3065902_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 373.0
TLS2_k127_3065902_3 dTDP biosynthetic process K00560,K00943 - 2.1.1.45,2.7.4.9 0.0000000000000000000000000000009993 129.0
TLS2_k127_3066947_0 ABC transporter transmembrane region K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 522.0
TLS2_k127_3066947_1 COGs COG1132 ABC-type multidrug transport system ATPase and permease components K06147,K06148 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 446.0
TLS2_k127_3066947_2 cellular response to dsDNA K07178 - 2.7.11.1 0.000000000000000000000000000000000001973 141.0
TLS2_k127_3068480_0 iron dependent repressor K03709 - - 0.00000000000000000000000000000000000000000000000000000000000075 217.0
TLS2_k127_3068480_1 Sulfotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000003414 214.0
TLS2_k127_3074892_0 - - - - 0.000000000000000000000001321 113.0
TLS2_k127_3074892_1 CHAT domain - - - 0.000000000000000000000005184 119.0
TLS2_k127_3074892_2 PFAM ATP-binding region, ATPase domain protein - - - 0.0000000000000000002828 98.0
TLS2_k127_3087521_0 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 607.0
TLS2_k127_3087521_1 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 327.0
TLS2_k127_3087521_2 phosphorelay signal transduction system K07670 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001657 282.0
TLS2_k127_3087521_3 Phosphoribosyl transferase domain K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000005772 224.0
TLS2_k127_3087521_4 PFAM UspA domain protein - - - 0.0003295 52.0
TLS2_k127_3087880_0 PhoQ Sensor K07682 GO:0000166,GO:0000287,GO:0001666,GO:0003032,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009593,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0019825,GO:0019826,GO:0020037,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042165,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0051606,GO:0051775,GO:0051776,GO:0070025,GO:0070026,GO:0070482,GO:0070483,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 314.0
TLS2_k127_3087880_1 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001957 284.0
TLS2_k127_3087880_2 Transcriptional regulator, Crp Fnr family K01420,K10914 - - 0.00000000000000000000000000000000000000000000000000002567 197.0
TLS2_k127_3087880_3 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000001301 111.0
TLS2_k127_3107432_0 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005819 617.0
TLS2_k127_3107432_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 505.0
TLS2_k127_3107432_2 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 416.0
TLS2_k127_3107432_3 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 334.0
TLS2_k127_3107432_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000195 238.0
TLS2_k127_3107432_5 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000003022 124.0
TLS2_k127_3107432_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000002499 98.0
TLS2_k127_3107432_7 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000003046 90.0
TLS2_k127_3107432_8 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000002473 100.0
TLS2_k127_3116597_0 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00303 - 1.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 553.0
TLS2_k127_3116597_1 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 440.0
TLS2_k127_3116597_2 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002275 275.0
TLS2_k127_3116597_3 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000008841 243.0
TLS2_k127_3116597_4 Pyrroloquinoline quinone biosynthesis protein PqqB K06136 - - 0.000000000000000000000000000000000000000000000000000484 196.0
TLS2_k127_3121967_0 PFAM acyl-CoA dehydrogenase domain protein - - - 2.253e-225 702.0
TLS2_k127_3121967_1 Formate dehydrogenase alpha subunit K00123,K05299 - 1.17.1.10,1.17.1.9 4.885e-197 628.0
TLS2_k127_3121967_2 PFAM acyl-CoA dehydrogenase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 546.0
TLS2_k127_3121967_3 Formate/nitrite transporter K06212 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 369.0
TLS2_k127_3121967_4 PFAM Enoyl-CoA hydratase isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 356.0
TLS2_k127_3121967_5 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336,K05299 - 1.17.1.10,1.6.5.3 0.000000000000000000000000000000000000000000000001231 177.0
TLS2_k127_3121967_6 oxidation-reduction process - - - 0.000000000000000000000000000000000000000000006236 169.0
TLS2_k127_3121967_7 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000000004498 152.0
TLS2_k127_3121967_8 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000009438 138.0
TLS2_k127_3121967_9 PFAM zinc finger, SWIM domain protein - - - 0.000002725 49.0
TLS2_k127_3123851_0 LppX_LprAFG lipoprotein K14954 - - 0.000000000000000000000000000000006291 136.0
TLS2_k127_3123851_1 - - - - 0.000000000000000001028 100.0
TLS2_k127_3144695_0 ATPase AAA-2 domain protein K03696 - - 0.0 1077.0
TLS2_k127_3144695_1 PFAM RNA binding S1 domain protein K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009067 324.0
TLS2_k127_3144695_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000001103 245.0
TLS2_k127_3144695_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000006451 93.0
TLS2_k127_3144695_4 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000003188 91.0
TLS2_k127_3153127_0 tungstate ion transport K01990,K07705,K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000003834 235.0
TLS2_k127_3153127_1 PFAM response regulator receiver - - - 0.000001856 54.0
TLS2_k127_3159705_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 460.0
TLS2_k127_3159705_1 3-keto-5-aminohexanoate cleavage protein K18013 - 2.3.1.247 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 427.0
TLS2_k127_3159705_2 AMP-binding enzyme K01912 - 6.2.1.30 0.0000000000000000000000000001121 120.0
TLS2_k127_3159705_3 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000004353 69.0
TLS2_k127_3170273_0 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 520.0
TLS2_k127_3170273_1 NAD-dependent epimerase dehydratase K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 359.0
TLS2_k127_3170273_2 Beta-lactamase K01286 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008223 334.0
TLS2_k127_3170273_3 Lysyl oxidase - - - 0.000000000000000000000000003412 129.0
TLS2_k127_3173114_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000313 286.0
TLS2_k127_3173114_1 Bacterial PH domain - - - 0.00000000000000000000000000000005066 132.0
TLS2_k127_3173114_2 Regulatory protein, FmdB family - - - 0.00000000000000000007797 92.0
TLS2_k127_3183774_0 Trimethylamine methyltransferase (MTTB) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 479.0
TLS2_k127_3183774_1 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008663 282.0
TLS2_k127_3183774_2 helix_turn_helix isocitrate lyase regulation - - - 0.0000000000000000000000000000000000000000000000000000003386 203.0
TLS2_k127_3183774_4 FAD dependent oxidoreductase - - - 0.0000000000000009852 78.0
TLS2_k127_318795_0 homoserine kinase type II (protein kinase fold) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001185 248.0
TLS2_k127_318795_1 GNAT acetyltransferase - - - 0.00000000000000000000000000000000000000000008983 169.0
TLS2_k127_318795_2 - - - - 0.00008754 53.0
TLS2_k127_3193070_0 PFAM Ubiquitin-conjugating - - - 0.000000000000000000000000004573 115.0
TLS2_k127_3193070_1 PFAM Mov34 MPN PAD-1 family - - - 0.0000000000000000000000001459 120.0
TLS2_k127_3193070_2 JAB1/Mov34/MPN/PAD-1 ubiquitin protease - - - 0.0000000000000000000007008 109.0
TLS2_k127_3214426_0 Amino acid permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 606.0
TLS2_k127_3214426_1 Alpha-2-macroglobulin family K06894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003392 458.0
TLS2_k127_3219576_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005393 466.0
TLS2_k127_3219576_1 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003222 276.0
TLS2_k127_3219576_10 - K19156 - - 0.00000001381 57.0
TLS2_k127_3219576_11 PFAM Phage derived protein Gp49-like (DUF891) - - - 0.00000004526 54.0
TLS2_k127_3219576_2 Bacterial sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002789 267.0
TLS2_k127_3219576_3 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000002388 203.0
TLS2_k127_3219576_5 ribonuclease activity - - - 0.0000000000000000000000000001387 119.0
TLS2_k127_3219576_6 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000007369 108.0
TLS2_k127_3219576_7 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000008156 97.0
TLS2_k127_3219576_8 Belongs to the peptidase S8 family - - - 0.00000000003427 72.0
TLS2_k127_3219576_9 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000008097 65.0
TLS2_k127_3225829_0 Carbohydrate binding domain K01183 GO:0003674,GO:0003824,GO:0004553,GO:0004568,GO:0005575,GO:0005576,GO:0006022,GO:0006026,GO:0006030,GO:0006032,GO:0006040,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016798,GO:0017144,GO:0042737,GO:0043170,GO:0044237,GO:0044248,GO:0046348,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.2.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003802 460.0
TLS2_k127_3225829_1 Belongs to the glycosyl hydrolase 18 family K01183 - 3.2.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 316.0
TLS2_k127_3225829_2 PFAM glycoside hydrolase, family 3 domain protein K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000001922 235.0
TLS2_k127_3225829_3 Belongs to the glycosyl hydrolase 18 family K01183 - 3.2.1.14 0.0000000000000000004437 102.0
TLS2_k127_3225829_4 PFAM chitin-binding domain 3 protein - - - 0.00000000001186 78.0
TLS2_k127_3231088_0 adenylyl cyclase class-3 4 guanylyl cyclase - - - 2.646e-291 945.0
TLS2_k127_3231088_1 PFAM sodium hydrogen exchanger - - - 3.097e-270 849.0
TLS2_k127_3231088_10 TVP38 TMEM64 family inner membrane protein ydjZ - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000007346 94.0
TLS2_k127_3231088_11 Dual specificity phosphatase, catalytic domain - - - 0.0000000013 67.0
TLS2_k127_3231088_12 ADP binding K08282,K13419 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.11.1 0.00000005877 64.0
TLS2_k127_3231088_2 ABC-type multidrug transport system ATPase and permease K06147 - - 1.765e-212 671.0
TLS2_k127_3231088_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009068 392.0
TLS2_k127_3231088_4 Putative esterase K07017 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 316.0
TLS2_k127_3231088_5 PFAM Methyltransferase type 12 - - - 0.000000000000000000000000000000000000000000000000000000000000007567 220.0
TLS2_k127_3231088_6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000001743 214.0
TLS2_k127_3231088_7 Major Facilitator Superfamily - - - 0.000000000000000000000000000000007831 142.0
TLS2_k127_3231088_8 ABC-type multidrug transport system, ATPase and permease K06147 - - 0.0000000000000000000000001704 106.0
TLS2_k127_3231088_9 extracellular polysaccharide biosynthetic process K07011,K16554 - - 0.00000000000000000000001767 115.0
TLS2_k127_3234084_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.053e-224 703.0
TLS2_k127_3234084_1 2-isopropylmalate synthase. Source PGD - - - 1.559e-222 704.0
TLS2_k127_3234084_2 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 9.86e-209 660.0
TLS2_k127_3234084_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003527 275.0
TLS2_k127_3234084_4 PFAM Methyltransferase type 11 K00598 - 2.1.1.144 0.000000000000000000000000000000000000000000000000000000000000000000000000000001092 271.0
TLS2_k127_3258147_0 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009412 372.0
TLS2_k127_3258147_1 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000003203 158.0
TLS2_k127_3258147_2 - - - - 0.00000004472 63.0
TLS2_k127_3258147_3 Cytochrome c oxidase subunit K02275 - 1.9.3.1 0.0000002726 61.0
TLS2_k127_3263739_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 9.994e-234 728.0
TLS2_k127_3263739_1 P22_AR N-terminal domain - - - 0.000000000000000000000000000000007533 138.0
TLS2_k127_3265570_0 PFAM NADH-Ubiquinone oxidoreductase (complex I), chain 5 L domain protein K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 629.0
TLS2_k127_3265570_1 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 597.0
TLS2_k127_3265570_10 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109 - - 0.00000001601 64.0
TLS2_k127_3265570_11 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109,K02113 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.000001863 58.0
TLS2_k127_3265570_2 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 453.0
TLS2_k127_3265570_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005906 338.0
TLS2_k127_3265570_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 310.0
TLS2_k127_3265570_5 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000151 188.0
TLS2_k127_3265570_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.0000000000000000000000000000003232 125.0
TLS2_k127_3265570_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 - 1.6.5.3 0.00000000000000000000000001047 115.0
TLS2_k127_3265570_8 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339,K05578 - 1.6.5.3 0.0000000000000000000706 96.0
TLS2_k127_3265570_9 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000006104 66.0
TLS2_k127_3265936_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 472.0
TLS2_k127_3265936_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 392.0
TLS2_k127_3265936_2 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003529 344.0
TLS2_k127_3265936_3 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 320.0
TLS2_k127_3265936_4 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 310.0
TLS2_k127_3265936_5 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000007006 250.0
TLS2_k127_3265936_6 positive regulation of growth K18829 - - 0.0000000000000000000000000001278 116.0
TLS2_k127_3265936_7 - - - - 0.00000000000000206 81.0
TLS2_k127_3270634_0 PFAM aspartate glutamate uridylate kinase K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009926 510.0
TLS2_k127_3270634_1 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 456.0
TLS2_k127_3296727_0 oligosaccharyl transferase activity K07151 - 2.4.99.18 0.00000000000000000000000000000000005805 153.0
TLS2_k127_3296727_1 Lysin motif - - - 0.0008696 50.0
TLS2_k127_3298418_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 1.49e-221 717.0
TLS2_k127_3298418_1 CO dehydrogenase flavoprotein C-terminal domain K11178 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 312.0
TLS2_k127_3298418_2 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008159 293.0
TLS2_k127_3298418_3 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002823 281.0
TLS2_k127_3298418_4 Protein of unknown function (DUF664) - - - 0.0000000000000000000000000000000000000000000000000000000000000000007713 231.0
TLS2_k127_3298418_5 PFAM Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000005225 160.0
TLS2_k127_3298418_6 Protein conserved in bacteria - - - 0.000000000000000000000000000002112 125.0
TLS2_k127_3298418_7 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000002373 112.0
TLS2_k127_3314349_0 PFAM ABC transporter transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 531.0
TLS2_k127_3334274_0 Bacterial membrane protein YfhO - - - 0.0000000000000000000000000000000000000000000000001185 201.0
TLS2_k127_3334274_1 Domain of unknown function (DUF892) - - - 0.000000000000000000000000000000000000000001806 161.0
TLS2_k127_3334274_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000114 138.0
TLS2_k127_3334274_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000006375 54.0
TLS2_k127_3338361_0 acetolactate synthase K01576,K01652 - 2.2.1.6,4.1.1.7 8.763e-205 653.0
TLS2_k127_3338361_1 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004123 502.0
TLS2_k127_3338361_10 - - - - 0.00000000000000000000006988 100.0
TLS2_k127_3338361_11 - - - - 0.00000000000000001151 83.0
TLS2_k127_3338361_12 Peptidyl-prolyl cis-trans isomerase - - - 0.00000000000002388 87.0
TLS2_k127_3338361_13 Immunity protein 53 - - - 0.000703 42.0
TLS2_k127_3338361_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007442 482.0
TLS2_k127_3338361_3 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 312.0
TLS2_k127_3338361_4 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001898 269.0
TLS2_k127_3338361_5 PFAM peptidase T2 asparaginase 2 K13051 - 3.4.19.5 0.00000000000000000000000000000000000000000000000000000000000000000001118 246.0
TLS2_k127_3338361_6 Parallel beta-helix repeats - - - 0.000000000000000000000000000000000000000000000000000000000000002559 243.0
TLS2_k127_3338361_7 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000002528 196.0
TLS2_k127_3338361_8 PFAM PfkB domain protein - - - 0.00000000000000000000000000000000000000000000000003664 190.0
TLS2_k127_3338361_9 Transcription factor zinc-finger - - - 0.0000000000000000000000000000000000000000000000002286 183.0
TLS2_k127_3343688_0 Glycosyl hydrolases family 2 K01192 - 3.2.1.25 6.074e-254 799.0
TLS2_k127_3343688_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006882 514.0
TLS2_k127_3343688_2 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009141 451.0
TLS2_k127_3343688_3 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 346.0
TLS2_k127_3353974_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 3.431e-222 697.0
TLS2_k127_3353974_1 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 311.0
TLS2_k127_3353974_2 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004233 276.0
TLS2_k127_3353974_3 ATP synthase, Delta/Epsilon chain, beta-sandwich domain K02114 - - 0.00000000000000000000000000000000000000009141 154.0
TLS2_k127_3353974_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000000000000000000000001428 138.0
TLS2_k127_3353974_5 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.000000000000000000000000000000001146 132.0
TLS2_k127_3353974_6 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000000000006906 89.0
TLS2_k127_3353974_7 domain, Protein - - - 0.00000000000009308 76.0
TLS2_k127_3353974_8 TIGRFAM F1 F0 ATPase, Methanosarcina type, subunit 2 - - - 0.000000000008799 69.0
TLS2_k127_3377772_0 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006688 341.0
TLS2_k127_3377772_1 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000004419 106.0
TLS2_k127_3380005_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 3.496e-207 660.0
TLS2_k127_3380005_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 471.0
TLS2_k127_3380005_2 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 423.0
TLS2_k127_3380005_3 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 391.0
TLS2_k127_3380005_4 Intracellular protease, PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000000000001658 258.0
TLS2_k127_3380005_5 PFAM Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000004244 149.0
TLS2_k127_3385371_0 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 342.0
TLS2_k127_3385371_1 Zinc metalloprotease (Elastase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000594 276.0
TLS2_k127_3385371_2 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000002088 55.0
TLS2_k127_3392691_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 1.209e-218 692.0
TLS2_k127_3392691_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000008751 117.0
TLS2_k127_3392691_2 RHS Repeat - - - 0.000000000000000001024 99.0
TLS2_k127_3392691_3 Calcineurin-like phosphoesterase - - - 0.000000000000000003894 93.0
TLS2_k127_3392691_4 Thioredoxin-like - - - 0.0007058 43.0
TLS2_k127_3408154_0 Sodium hydrogen exchanger - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 346.0
TLS2_k127_3408154_1 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003453 293.0
TLS2_k127_3408154_2 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.000000000000000000000000000000000000000000000000000000002361 211.0
TLS2_k127_3408154_3 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000001176 186.0
TLS2_k127_3408154_4 COGs COG2452 site-specific integrase-resolvase - - - 0.000000000000000000000000000000007445 129.0
TLS2_k127_3408154_5 Belongs to the UPF0107 family K09128 - - 0.000000001524 71.0
TLS2_k127_3408154_6 COGs COG2452 site-specific integrase-resolvase - - - 0.0001318 46.0
TLS2_k127_3419627_0 COGs COG0674 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductase alpha subunit K00174 - 1.2.7.11,1.2.7.3 1.05e-255 801.0
TLS2_k127_3419627_1 PFAM acetyl-CoA hydrolase transferase K01067 - 3.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009642 563.0
TLS2_k127_3419627_2 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005087 365.0
TLS2_k127_3419627_3 alanine dehydrogenase activity K00259 GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009653,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030312,GO:0030435,GO:0032502,GO:0036293,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 331.0
TLS2_k127_3419627_4 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000002175 207.0
TLS2_k127_3419627_5 nucleotidyltransferase activity K07075 - - 0.00000000000000000000000000000000000006144 147.0
TLS2_k127_3419627_6 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.0000000000000000000000000000000000225 139.0
TLS2_k127_3419627_7 alpha beta - - - 0.0000000000000000000000001066 110.0
TLS2_k127_3420082_0 PFAM ABC transporter related K01990,K16907 - - 0.0000000000000000000000000000000000000000000000000000000000005975 213.0
TLS2_k127_3420082_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000009856 215.0
TLS2_k127_3420082_2 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000054 199.0
TLS2_k127_3420082_3 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000006802 138.0
TLS2_k127_3420082_4 PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding K07443 - - 0.000000000000000000007423 96.0
TLS2_k127_3420082_5 Cysteine-rich secretory protein family - - - 0.000000000000000000236 99.0
TLS2_k127_3425486_0 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007095 420.0
TLS2_k127_3425486_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 374.0
TLS2_k127_3425486_2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 306.0
TLS2_k127_3425486_3 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003086 304.0
TLS2_k127_3425486_4 TIGRFAM cell division protein FtsW K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001985 281.0
TLS2_k127_3425486_6 Cell wall formation K00075 - 1.3.1.98 0.000008518 51.0
TLS2_k127_3425486_7 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00001502 48.0
TLS2_k127_34368_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.21.53 1.508e-231 741.0
TLS2_k127_34368_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 6.892e-200 630.0
TLS2_k127_34368_2 Belongs to the aldehyde dehydrogenase family - - - 3.93e-197 625.0
TLS2_k127_34368_3 Acetyltransferase (GNAT) domain - - - 0.0001954 50.0
TLS2_k127_3444651_0 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 390.0
TLS2_k127_3444651_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 371.0
TLS2_k127_3444651_2 DNA polymerase III, delta subunit K02341 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000003014 221.0
TLS2_k127_3444651_3 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000002458 149.0
TLS2_k127_3444651_4 Cellulase (glycosyl hydrolase family 5) - - - 0.00000001568 66.0
TLS2_k127_3447271_0 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 511.0
TLS2_k127_3447271_1 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000005119 201.0
TLS2_k127_3453688_0 PFAM PfkB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001738 236.0
TLS2_k127_3453688_1 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000002201 189.0
TLS2_k127_3453688_2 permease - - - 0.0000000000000000000000000000000000000000306 168.0
TLS2_k127_3453688_3 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.00000000000000000000000000000000000000148 160.0
TLS2_k127_3453688_4 PFAM phosphatidate cytidylyltransferase - - - 0.000000000000000000000000000000004603 136.0
TLS2_k127_3453688_5 - - - - 0.00000000000000004041 87.0
TLS2_k127_3456668_0 Two component regulator propeller - - - 1.385e-201 643.0
TLS2_k127_3456668_1 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 360.0
TLS2_k127_3456668_2 acid phosphatase activity - - - 0.000000000000004677 78.0
TLS2_k127_3473316_0 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00239 - 1.3.5.1,1.3.5.4 5.433e-247 775.0
TLS2_k127_3473316_1 PFAM single-stranded nucleic acid binding R3H domain protein - - - 1.577e-195 623.0
TLS2_k127_3473316_10 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.000000000000000008308 87.0
TLS2_k127_3473316_2 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 325.0
TLS2_k127_3473316_3 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000000005563 239.0
TLS2_k127_3473316_4 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000002964 227.0
TLS2_k127_3473316_5 PFAM peptidylprolyl isomerase FKBP-type K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000003864 229.0
TLS2_k127_3473316_6 Putative regulatory protein - - - 0.00000000000000000000000000000000000000002079 156.0
TLS2_k127_3473316_7 Peptidyl-prolyl cis-trans isomerase K01802,K03767,K03772 - 5.2.1.8 0.00000000000000000000000001253 123.0
TLS2_k127_3473316_8 - - - - 0.0000000000000000000000004729 117.0
TLS2_k127_3473316_9 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000000007581 109.0
TLS2_k127_3476487_0 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 576.0
TLS2_k127_3476487_1 CBS domain containing protein K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004998 434.0
TLS2_k127_3476487_2 PFAM cyclic nucleotide-binding K16922 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006071 402.0
TLS2_k127_3476487_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000008533 202.0
TLS2_k127_3476487_4 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000006516 93.0
TLS2_k127_3476487_5 - - - - 0.000000008645 61.0
TLS2_k127_3503676_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004471 448.0
TLS2_k127_3503676_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 410.0
TLS2_k127_3503676_2 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 293.0
TLS2_k127_3503676_3 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000009321 193.0
TLS2_k127_3503676_4 Protein of unknown function (DUF971) K03593 - - 0.0000000000000000000002033 100.0
TLS2_k127_3512566_0 PFAM Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 560.0
TLS2_k127_3512566_1 Putative glutamine amidotransferase K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007658 544.0
TLS2_k127_3512566_10 ATPase histidine kinase DNA gyrase B HSP90 domain protein K07636 - 2.7.13.3 0.000000000000000000007682 108.0
TLS2_k127_3512566_11 CAMP-dependent protein kinase regulatory subunit K04739 GO:0000003,GO:0000166,GO:0000187,GO:0000226,GO:0000280,GO:0001704,GO:0001707,GO:0001932,GO:0001933,GO:0001934,GO:0002682,GO:0002683,GO:0002694,GO:0002695,GO:0003006,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0005952,GO:0006355,GO:0006357,GO:0006464,GO:0006468,GO:0006469,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0007010,GO:0007015,GO:0007017,GO:0007049,GO:0007143,GO:0007154,GO:0007162,GO:0007163,GO:0007165,GO:0007267,GO:0007268,GO:0007274,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007369,GO:0007389,GO:0007498,GO:0007507,GO:0007591,GO:0007596,GO:0007599,GO:0007610,GO:0007611,GO:0007612,GO:0007613,GO:0007635,GO:0008103,GO:0008150,GO:0008152,GO:0008283,GO:0008285,GO:0008306,GO:0008355,GO:0008603,GO:0009611,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009798,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009994,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010628,GO:0010639,GO:0010646,GO:0010647,GO:0010648,GO:0010721,GO:0010738,GO:0010927,GO:0010948,GO:0014706,GO:0014855,GO:0015630,GO:0016020,GO:0016043,GO:0016310,GO:0016325,GO:0017076,GO:0019207,GO:0019210,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019932,GO:0019933,GO:0019935,GO:0019953,GO:0021700,GO:0022402,GO:0022407,GO:0022408,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030029,GO:0030036,GO:0030104,GO:0030154,GO:0030155,GO:0030234,GO:0030239,GO:0030291,GO:0030435,GO:0030551,GO:0030552,GO:0030554,GO:0030587,GO:0030951,GO:0030952,GO:0031032,GO:0031154,GO:0031156,GO:0031285,GO:0031288,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031594,GO:0031625,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0032870,GO:0032878,GO:0032944,GO:0032945,GO:0032989,GO:0032991,GO:0033002,GO:0033043,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035265,GO:0035556,GO:0036094,GO:0036211,GO:0040007,GO:0040020,GO:0042048,GO:0042060,GO:0042127,GO:0042129,GO:0042130,GO:0042221,GO:0042303,GO:0042325,GO:0042326,GO:0042327,GO:0042493,GO:0042592,GO:0042692,GO:0042802,GO:0042995,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043405,GO:0043406,GO:0043408,GO:0043410,GO:0043412,GO:0043434,GO:0043549,GO:0043900,GO:0043901,GO:0043934,GO:0043949,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044853,GO:0045121,GO:0045202,GO:0045214,GO:0045471,GO:0045595,GO:0045596,GO:0045786,GO:0045835,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046006,GO:0046007,GO:0046677,GO:0048285,GO:0048332,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048520,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048589,GO:0048598,GO:0048599,GO:0048609,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048856,GO:0048869,GO:0048871,GO:0048878,GO:0050670,GO:0050672,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050795,GO:0050817,GO:0050863,GO:0050865,GO:0050866,GO:0050868,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051018,GO:0051093,GO:0051128,GO:0051129,GO:0051146,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051249,GO:0051250,GO:0051252,GO:0051321,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051447,GO:0051703,GO:0051704,GO:0051716,GO:0051726,GO:0051783,GO:0051784,GO:0055001,GO:0055002,GO:0055017,GO:0060038,GO:0060255,GO:0060259,GO:0060281,GO:0060283,GO:0060284,GO:0060419,GO:0060537,GO:0061061,GO:0061695,GO:0061939,GO:0065007,GO:0065008,GO:0065009,GO:0070663,GO:0070664,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071902,GO:0071944,GO:0072359,GO:0072375,GO:0080090,GO:0090036,GO:0090038,GO:0090702,GO:0097159,GO:0097305,GO:0097367,GO:0097435,GO:0097546,GO:0098589,GO:0098590,GO:0098772,GO:0098805,GO:0098857,GO:0098916,GO:0099120,GO:0099536,GO:0099537,GO:0120025,GO:0120038,GO:0140013,GO:1900193,GO:1900194,GO:1901265,GO:1901363,GO:1901564,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902494,GO:1902531,GO:1902532,GO:1902533,GO:1902911,GO:1903037,GO:1903038,GO:1903046,GO:1903429,GO:1903430,GO:1903506,GO:1903538,GO:1905879,GO:1905880,GO:1990234,GO:2000112,GO:2000114,GO:2000241,GO:2000242,GO:2000253,GO:2000479,GO:2000480,GO:2001141 - 0.0000000005912 71.0
TLS2_k127_3512566_12 peptidyl-tyrosine sulfation - - - 0.0000001727 64.0
TLS2_k127_3512566_2 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004305 498.0
TLS2_k127_3512566_3 PFAM AAA-4 family protein K02444,K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009745 494.0
TLS2_k127_3512566_4 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000014 262.0
TLS2_k127_3512566_5 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K09833 GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009987,GO:0010189,GO:0018130,GO:0042360,GO:0042362,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617 2.5.1.115,2.5.1.116 0.00000000000000000000000000000000000000000000000000000000000000000001759 243.0
TLS2_k127_3512566_6 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K02548,K03179,K17105 - 2.5.1.39,2.5.1.42,2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000002655 229.0
TLS2_k127_3512566_7 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000000001451 173.0
TLS2_k127_3512566_8 HIT domain - - - 0.0000000000000000000000000000000001376 139.0
TLS2_k127_3512566_9 His Kinase A (phosphoacceptor) domain K07768 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564 2.7.13.3 0.000000000000000000000000000103 130.0
TLS2_k127_3549866_0 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005713 321.0
TLS2_k127_3549866_1 PFAM glycosyl transferase family 39 K14340 - - 0.000000000000000000000000000000000000000000009357 186.0
TLS2_k127_3549866_2 C-terminal four TMM region of protein-O-mannosyltransferase - - - 0.0000000000000000000000000000000000000000104 175.0
TLS2_k127_3549866_3 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000005473 168.0
TLS2_k127_3549866_4 Belongs to the UPF0102 family K07460 - - 0.0000000000000000000002508 98.0
TLS2_k127_3549866_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000004118 67.0
TLS2_k127_3550208_0 Transcriptional regulator (LacI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 343.0
TLS2_k127_3550208_1 Pfam:DUF385 - - - 0.000000000000000000000000000000000002319 144.0
TLS2_k127_3550208_2 Periplasmic binding protein - - - 0.00000000000003972 74.0
TLS2_k127_3550365_0 Transcriptional activator domain - - - 2.423e-280 898.0
TLS2_k127_3550365_1 Homocysteine S-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 593.0
TLS2_k127_3550365_2 peroxiredoxin activity K01055,K01607,K14727 - 3.1.1.24,4.1.1.44 0.00000000000000000000000000000000000000000000000003471 181.0
TLS2_k127_3550365_3 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000000000000000002506 125.0
TLS2_k127_3550365_4 Protocatechuate 3,4-dioxygenase beta subunit N terminal K00449 - 1.13.11.3 0.0000000000000002848 79.0
TLS2_k127_3554808_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000008306 120.0
TLS2_k127_3554808_1 Transposase DDE domain - - - 0.00000000000000001478 83.0
TLS2_k127_3554808_2 - - - - 0.0001742 51.0
TLS2_k127_3557136_0 glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000542 355.0
TLS2_k127_3557136_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000545 334.0
TLS2_k127_3557136_2 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000002165 198.0
TLS2_k127_3557136_3 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms K07027 - - 0.00000000000000000000000004656 121.0
TLS2_k127_3557136_4 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000003926 100.0
TLS2_k127_3557136_5 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000001389 73.0
TLS2_k127_3560087_0 PFAM type II secretion system protein E K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 619.0
TLS2_k127_3560087_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000803 602.0
TLS2_k127_3560087_10 PFAM type II secretion system protein K12510 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004414 258.0
TLS2_k127_3560087_11 Two component transcriptional regulator, LuxR family - - - 0.00000000000000000000000000000000000000000000000000000000000000001325 231.0
TLS2_k127_3560087_12 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000003952 212.0
TLS2_k127_3560087_14 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.0000000000000000000000000000000000000000000002798 174.0
TLS2_k127_3560087_15 PFAM low molecular weight phosphotyrosine protein phosphatase K01104 - 3.1.3.48 0.0000000000000000000000000000000000007601 145.0
TLS2_k127_3560087_16 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000001777 147.0
TLS2_k127_3560087_17 domain, Protein - - - 0.000000000000000000000000001283 121.0
TLS2_k127_3560087_18 Methyltransferase domain - - - 0.00000000000000000004843 93.0
TLS2_k127_3560087_2 RNA-metabolising metallo-beta-lactamase K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 533.0
TLS2_k127_3560087_3 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 362.0
TLS2_k127_3560087_4 PFAM response regulator receiver K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004624 338.0
TLS2_k127_3560087_5 ATP hydrolysis coupled proton transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000118 299.0
TLS2_k127_3560087_6 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003659 287.0
TLS2_k127_3560087_7 PFAM type II secretion system protein K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001239 282.0
TLS2_k127_3560087_8 oligosaccharyl transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001838 289.0
TLS2_k127_3560087_9 histidine kinase, dimerisation and phosphoacceptor region K07777 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006095 279.0
TLS2_k127_3562002_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1279.0
TLS2_k127_3562002_1 domain, Protein - - - 0.000000000000000000000000000000000000000000000000002266 194.0
TLS2_k127_3567862_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006222 568.0
TLS2_k127_3589608_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 1.502e-271 864.0
TLS2_k127_3589608_1 PFAM NAD-dependent epimerase dehydratase K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004851 473.0
TLS2_k127_3589608_10 PFAM Archaeal ATPase - - - 0.0000000002019 73.0
TLS2_k127_3589608_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007916 474.0
TLS2_k127_3589608_3 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009513 396.0
TLS2_k127_3589608_4 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 314.0
TLS2_k127_3589608_5 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 303.0
TLS2_k127_3589608_6 PFAM O-antigen polymerase - - - 0.000000000000000000000000000000000000000000000000000000000032 224.0
TLS2_k127_3589608_7 GtrA-like protein - - - 0.00000000000000000000000000000000004459 143.0
TLS2_k127_3589608_8 PFAM Archaeal ATPase - - - 0.0000000000003645 81.0
TLS2_k127_3608015_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004753 545.0
TLS2_k127_3608015_1 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01840 - 5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 416.0
TLS2_k127_3608015_2 Helix-turn-helix domain K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 366.0
TLS2_k127_3608015_3 ADP-glyceromanno-heptose 6-epimerase activity K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000001963 197.0
TLS2_k127_3608015_4 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840 - 5.4.2.2,5.4.2.8 0.000000000000000000000000001257 114.0
TLS2_k127_3608015_5 Belongs to the citrate synthase family K01647 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.3.3.1 0.000000000000000000000005537 103.0
TLS2_k127_3625985_0 domain protein K01212,K12287,K20276 - 3.2.1.65 0.000000000000000000000000000000000001408 157.0
TLS2_k127_3625985_1 PFAM glycosyl transferase family 39 - - - 0.00000000744 68.0
TLS2_k127_3625985_2 Ecdysteroid kinase - - - 0.0000003022 54.0
TLS2_k127_3628797_0 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008152 338.0
TLS2_k127_3628797_1 Domain of unknown function (DUF4380) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001276 281.0
TLS2_k127_3628797_2 TIGRFAM carbohydrate kinase, thermoresistant glucokinase family K00851 - 2.7.1.12 0.0000000000000000000000000000000000000000000000000002887 189.0
TLS2_k127_3628797_3 Tex-like protein N-terminal domain protein K06959 - - 0.00000000000000000000000000000000000000002133 162.0
TLS2_k127_3629788_0 Ribosomal RNA methyltransferase (FmrO) K18845 - 2.1.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002031 282.0
TLS2_k127_3629788_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000001908 248.0
TLS2_k127_3629788_2 GDP-mannose 4,6 dehydratase K01784 - 5.1.3.2 0.000000000000000005013 83.0
TLS2_k127_3638101_0 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 305.0
TLS2_k127_3638101_1 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000239 264.0
TLS2_k127_3638101_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000549 246.0
TLS2_k127_3638101_3 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000002244 226.0
TLS2_k127_3638101_4 PFAM aminotransferase class V - - - 0.0000000000000000000000000000000000000000000000000000000000006272 226.0
TLS2_k127_3638101_5 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000001929 216.0
TLS2_k127_3638101_6 Histidine kinase - - - 0.00000000000000000000000000000000002261 148.0
TLS2_k127_3638101_7 helix_turn_helix, Lux Regulon - - - 0.000003721 53.0
TLS2_k127_3644767_0 Hep Hag repeat protein - - - 0.0000000000000000000000000000006494 134.0
TLS2_k127_3644767_2 PFAM Protein kinase domain - - - 0.000000005667 58.0
TLS2_k127_3646996_0 WD domain, G-beta repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 569.0
TLS2_k127_3646996_1 CHAT domain - - - 0.000000000000000000000000000000000000000000000000002368 199.0
TLS2_k127_3646996_2 PFAM Formylglycine-generating sulfatase enzyme K18912 - 1.14.99.50 0.000000000000000000000000000000000000005669 169.0
TLS2_k127_3646996_3 PFAM restriction endonuclease K07448 - - 0.00000000000000000000000000361 120.0
TLS2_k127_3646996_4 TIGRFAM transposase, IS605 OrfB family, central region - - - 0.0000000000000000000000003091 107.0
TLS2_k127_36519_0 Domain of unknown function (DUF348) - - - 0.0000000000000000000000000000000000000000000000000000000000000000125 239.0
TLS2_k127_36519_1 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000001857 211.0
TLS2_k127_3657925_0 GMC oxidoreductase K03333 - 1.1.3.6 0.0 1257.0
TLS2_k127_3672323_0 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006134 375.0
TLS2_k127_3672323_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.000000000000009981 78.0
TLS2_k127_3677557_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 530.0
TLS2_k127_3677557_1 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000002455 263.0
TLS2_k127_3677557_2 belongs to the thioredoxin family K03671 - - 0.00000000000000000000000000000000001503 138.0
TLS2_k127_3687712_1 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000000314 161.0
TLS2_k127_3687712_2 C-terminal four TMM region of protein-O-mannosyltransferase - - - 0.00000000001559 77.0
TLS2_k127_3687712_3 Glycosyltransferase family 87 K13671 - - 0.000005741 58.0
TLS2_k127_3698599_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 1.177e-294 914.0
TLS2_k127_3698599_1 TIGRFAM RarD protein, DMT superfamily transporter K05786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000558 335.0
TLS2_k127_3698599_2 - - - - 0.0003981 53.0
TLS2_k127_369994_0 Formiminotransferase domain, N-terminal subdomain K00603,K13990 - 2.1.2.5,4.3.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007531 486.0
TLS2_k127_369994_1 NUBPL iron-transfer P-loop NTPase - - - 0.00000000000000000000000000000000000000000007738 163.0
TLS2_k127_3706976_0 SMART alpha amylase, catalytic sub domain K01208 - 3.2.1.133,3.2.1.135,3.2.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 609.0
TLS2_k127_3706976_1 Beta-eliminating lyase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 402.0
TLS2_k127_3706976_10 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000005753 116.0
TLS2_k127_3706976_2 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 366.0
TLS2_k127_3706976_3 Uncharacterized protein conserved in bacteria (DUF2330) - - - 0.00000000000000000000000000000000000000000000000000000000000000004653 238.0
TLS2_k127_3706976_4 Putative cyclase K07130 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000000001363 224.0
TLS2_k127_3706976_5 Flavin containing amine oxidoreductase K06955 - - 0.00000000000000000000000000000000000000000000000000000009674 200.0
TLS2_k127_3706976_6 domain in sensory proteins (DUF2308) - - - 0.0000000000000000000000000000000000000000000002278 174.0
TLS2_k127_3706976_7 enterobactin catabolic process K07214 - - 0.0000000000000000000000000000000001897 148.0
TLS2_k127_3706976_8 COGs COG4339 conserved - - - 0.000000000000000000000000000000001377 138.0
TLS2_k127_3706976_9 RNase_H superfamily K07502 - - 0.00000000000000000000000000114 119.0
TLS2_k127_370838_0 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007006 435.0
TLS2_k127_370838_1 Protein of unknown function (DUF3105) - - - 0.00000000000000000000000000000000000000000000001224 176.0
TLS2_k127_370838_2 Protein of unknown function (DUF3105) - - - 0.0000000000000000000000000000000000005001 148.0
TLS2_k127_372348_0 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 527.0
TLS2_k127_372348_1 NB-ARC domain - - - 0.000000000000002594 79.0
TLS2_k127_3742189_0 XFP N-terminal domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000556 193.0
TLS2_k127_3742189_1 MgtC family K07507 - - 0.000000000000000000000000000000001051 134.0
TLS2_k127_3742189_2 membrane protein of uknown function UCP014873 - - - 0.000000000000001744 89.0
TLS2_k127_3742189_3 Protein of unknown function (DUF1328) - - - 0.0000009853 51.0
TLS2_k127_374812_0 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 487.0
TLS2_k127_374812_1 PFAM basic membrane lipoprotein K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 466.0
TLS2_k127_374812_2 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 423.0
TLS2_k127_374812_3 PFAM AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 389.0
TLS2_k127_374812_4 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005311 324.0
TLS2_k127_374812_5 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000002626 243.0
TLS2_k127_3750066_0 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 546.0
TLS2_k127_3750066_1 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000009451 226.0
TLS2_k127_3750066_2 ABC-type transport system involved in multi-copper enzyme maturation, permease K01992 - - 0.00000000000000000000000000000000000001535 154.0
TLS2_k127_3750066_3 CAAX protease self-immunity - - - 0.00000000003316 67.0
TLS2_k127_3751767_0 PFAM ABC transporter transmembrane region - - - 2.997e-228 722.0
TLS2_k127_3751767_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000001373 139.0
TLS2_k127_3752492_0 TIGRFAM NHLM bacteriocin system ABC transporter, peptidase ATP-binding protein - - - 2.564e-243 773.0
TLS2_k127_3752492_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 377.0
TLS2_k127_3752492_2 Magnesium chelatase, subunit ChlI K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005026 344.0
TLS2_k127_3752492_3 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005962 276.0
TLS2_k127_3752492_4 - - - - 0.000000000000000001653 93.0
TLS2_k127_3752492_6 TIGRFAM type 2 lantibiotic, mersacidin lichenicidin family - - - 0.000000000002792 68.0
TLS2_k127_3777491_0 glutaminyl-tRNA synthetase K01886 - 6.1.1.18 5.463e-236 744.0
TLS2_k127_3777491_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000408 528.0
TLS2_k127_3777491_10 cAMP-dependent protein kinase regulatory subunit K04739 GO:0000003,GO:0000166,GO:0000228,GO:0000785,GO:0000790,GO:0001932,GO:0001933,GO:0002831,GO:0002832,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005886,GO:0005952,GO:0006469,GO:0006950,GO:0006979,GO:0007154,GO:0008104,GO:0008150,GO:0008277,GO:0008603,GO:0009266,GO:0009267,GO:0009405,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009653,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0010563,GO:0010570,GO:0010605,GO:0010639,GO:0010646,GO:0010648,GO:0016020,GO:0017076,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019887,GO:0019954,GO:0022603,GO:0023051,GO:0023057,GO:0030154,GO:0030234,GO:0030291,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0030551,GO:0030552,GO:0030554,GO:0031279,GO:0031281,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031667,GO:0031668,GO:0031669,GO:0031974,GO:0031981,GO:0032101,GO:0032102,GO:0032104,GO:0032105,GO:0032107,GO:0032108,GO:0032268,GO:0032269,GO:0032386,GO:0032388,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032880,GO:0032991,GO:0033036,GO:0033043,GO:0033157,GO:0033554,GO:0033673,GO:0034305,GO:0034599,GO:0034605,GO:0034613,GO:0036094,GO:0036170,GO:0036180,GO:0040007,GO:0040008,GO:0042173,GO:0042221,GO:0042325,GO:0042326,GO:0042594,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043549,GO:0043934,GO:0043936,GO:0043937,GO:0043938,GO:0043943,GO:0043945,GO:0043949,GO:0043951,GO:0044092,GO:0044093,GO:0044182,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045595,GO:0045597,GO:0045744,GO:0045761,GO:0045762,GO:0045786,GO:0045859,GO:0045881,GO:0045926,GO:0045936,GO:0046578,GO:0046580,GO:0046822,GO:0046824,GO:0046825,GO:0046827,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051056,GO:0051058,GO:0051094,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051246,GO:0051248,GO:0051338,GO:0051339,GO:0051348,GO:0051349,GO:0051445,GO:0051447,GO:0051641,GO:0051704,GO:0051716,GO:0051726,GO:0051783,GO:0051784,GO:0060255,GO:0060258,GO:0060341,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070727,GO:0070887,GO:0071496,GO:0071900,GO:0071901,GO:0071944,GO:0080090,GO:0080134,GO:0090087,GO:0090316,GO:0097159,GO:0097271,GO:0097367,GO:0098772,GO:0106070,GO:0106072,GO:0110033,GO:0110034,GO:1900428,GO:1900429,GO:1900434,GO:1900435,GO:1900443,GO:1900444,GO:1901265,GO:1901363,GO:1902531,GO:1902532,GO:1902659,GO:1902660,GO:1903664,GO:1903666,GO:1903827,GO:1903829,GO:1904951,GO:2000241,GO:2000242,GO:2000479,GO:2000480 - 0.0000003054 64.0
TLS2_k127_3777491_2 transmembrane signaling receptor activity K03406,K17763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 309.0
TLS2_k127_3777491_3 Cytochrome c3 - - - 0.0000000000000000000000000000000000000000000000000000000000002433 218.0
TLS2_k127_3777491_4 Ca2 -binding protein (EF-Hand superfamily K00302,K00329,K00356,K00362,K00366,K00372,K00491,K02639,K05927,K11107,K13819,K21479,K21572 GO:0001505,GO:0003674,GO:0003824,GO:0004497,GO:0004517,GO:0006807,GO:0006809,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016705,GO:0016709,GO:0017144,GO:0034641,GO:0042133,GO:0042136,GO:0044237,GO:0044249,GO:0044271,GO:0046209,GO:0055114,GO:0065007,GO:0065008,GO:0072593,GO:1903409,GO:2001057 1.12.5.1,1.14.14.47,1.5.3.1,1.6.5.3,1.6.99.3,1.7.1.15,1.7.7.1,2.1.1.272 0.00000000000000000000000000000000000000000000000000005381 211.0
TLS2_k127_3777491_5 SUF system FeS assembly protein, NifU family K04488 - - 0.0000000000000000000000000000000000226 141.0
TLS2_k127_3777491_6 ABC transporter - - - 0.0000000000000000000000000000003022 124.0
TLS2_k127_3777491_7 of nitrite reductase and ring-hydroxylating K05710 - - 0.00000000000000000000000008798 109.0
TLS2_k127_3777491_8 PFAM TM1410 hypothetical-related protein K21006 - - 0.0000000000000000001852 99.0
TLS2_k127_3777491_9 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.00000000000000305 75.0
TLS2_k127_377855_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 502.0
TLS2_k127_377855_1 bifunctional purine biosynthesis protein K00602 GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0003937,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0009058,GO:0009060,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009653,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016741,GO:0016742,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019637,GO:0019693,GO:0019953,GO:0022402,GO:0022413,GO:0022414,GO:0030154,GO:0030435,GO:0030437,GO:0032502,GO:0032505,GO:0034293,GO:0034641,GO:0034654,GO:0043934,GO:0043935,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044703,GO:0045333,GO:0046040,GO:0046390,GO:0046483,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0051321,GO:0051704,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903046 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 475.0
TLS2_k127_3785186_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 - 2.7.1.11 4.434e-303 945.0
TLS2_k127_3785186_1 Oligopeptidase F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006316 429.0
TLS2_k127_3785186_2 PFAM peptidase S1 and S6, chymotrypsin Hap K08070 - 1.3.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000001735 254.0
TLS2_k127_3788033_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000002592 269.0
TLS2_k127_3788033_1 PFAM Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000000000000009749 209.0
TLS2_k127_3788033_2 PFAM PHA accumulation regulator DNA-binding protein - - - 0.00000000000000000000000000000001906 133.0
TLS2_k127_3788033_3 - - - - 0.000000000000001765 85.0
TLS2_k127_3788033_4 Poly(hydroxyalcanoate) granule associated protein (phasin) - - - 0.000000006478 62.0
TLS2_k127_3813744_0 antibiotic catabolic process - - - 0.000003911 60.0
TLS2_k127_3831109_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458,K14660 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 444.0
TLS2_k127_3831109_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 353.0
TLS2_k127_3831109_2 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000001522 237.0
TLS2_k127_3831109_3 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03635,K21142 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000000000000002165 223.0
TLS2_k127_3831109_4 Peptidase MA superfamily - - - 0.000000000000000000000000000000000000000000000000000000002412 215.0
TLS2_k127_3831109_5 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000000003724 196.0
TLS2_k127_3831109_6 dTDP-4-dehydrorhamnose reductase activity K00067 - 1.1.1.133 0.000000000000000000000000000000000000000008912 164.0
TLS2_k127_3831109_7 PFAM LmbE family protein - - - 0.000004886 48.0
TLS2_k127_384697_0 repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 599.0
TLS2_k127_384697_1 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 401.0
TLS2_k127_3847672_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 456.0
TLS2_k127_3847672_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 429.0
TLS2_k127_3847672_2 imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000002101 240.0
TLS2_k127_3855682_0 ABC transporter K06147 - - 1.569e-226 720.0
TLS2_k127_3855682_1 Aminotransferase class-V K01556 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0019439,GO:0019441,GO:0019752,GO:0030429,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 556.0
TLS2_k127_3855682_2 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 446.0
TLS2_k127_3855682_3 PFAM multicopper oxidase type 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 440.0
TLS2_k127_3855682_4 tryptophan 2,3-dioxygenase activity K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 353.0
TLS2_k127_3855682_5 Protein of unknown function DUF126 K09128 - - 0.0000000000000000000000000001893 121.0
TLS2_k127_3861619_0 Penicillin amidase K01434,K07116 - 3.5.1.11,3.5.1.97 8.891e-212 687.0
TLS2_k127_3861619_1 Condensation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 472.0
TLS2_k127_3873165_0 Class II Aldolase and Adducin N-terminal domain - - - 0.0 1037.0
TLS2_k127_3873165_1 elongation factor Tu domain 2 protein K02355 - - 1.889e-217 694.0
TLS2_k127_3873165_2 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 462.0
TLS2_k127_3873165_3 iron-sulfur cluster assembly K02426,K07125 - - 0.000000000000000000000000000000000000000000000000000268 188.0
TLS2_k127_3873165_4 FGGY family of carbohydrate kinases, N-terminal domain K00848,K00879,K01813 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008993,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575 2.7.1.5,2.7.1.51,5.3.1.14 0.0000000000000000000000000000000000004863 142.0
TLS2_k127_3878834_0 PFAM Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 288.0
TLS2_k127_3878834_1 phosphatidylinositol kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001489 261.0
TLS2_k127_3878834_2 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002836 245.0
TLS2_k127_3878834_3 alpha-ribazole phosphatase activity K02226,K15634,K22305 - 3.1.3.3,3.1.3.73,5.4.2.12 0.0000000000000000000000000000000000000000000000000000000001595 212.0
TLS2_k127_3878834_4 Protein of unknown function (DUF3090) - - - 0.00000000000000000000000000000000000000000001153 169.0
TLS2_k127_3878834_5 AAA domain K02282 - - 0.00000000000000000000000000000000000000000003938 175.0
TLS2_k127_3878834_6 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000001007 174.0
TLS2_k127_3878834_7 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633,K07589 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564 1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8 0.0000000000000000000000000000002089 128.0
TLS2_k127_3878834_8 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000008026 119.0
TLS2_k127_3878834_9 - - - - 0.0000000000000004903 89.0
TLS2_k127_3881545_0 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 9.562e-255 805.0
TLS2_k127_3881545_1 peptidase S9 prolyl oligopeptidase active site K01303 - 3.4.19.1 6.955e-233 739.0
TLS2_k127_3881545_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 525.0
TLS2_k127_3881545_3 nucleoside-diphosphate sugar epimerase K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006971 444.0
TLS2_k127_3881545_4 PFAM penicillin-binding protein transpeptidase K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 385.0
TLS2_k127_3881545_5 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005156 296.0
TLS2_k127_3881545_6 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000002136 221.0
TLS2_k127_3881545_7 PAS domain - - - 0.00000000000000000000000000000004528 132.0
TLS2_k127_3881545_8 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000193 93.0
TLS2_k127_389179_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 6.032e-241 761.0
TLS2_k127_389179_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 376.0
TLS2_k127_389179_2 methyltransferase - - - 0.0000000000000000000000000000000000000000000000001022 186.0
TLS2_k127_3906228_0 PFAM ABC transporter related K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 458.0
TLS2_k127_3906228_1 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000001497 203.0
TLS2_k127_3906228_2 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000002299 171.0
TLS2_k127_3906228_3 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000001339 106.0
TLS2_k127_390875_0 E1-E2 ATPase K12949,K12956,K17686 GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0009405,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0042221,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046688,GO:0050896,GO:0051704,GO:0071944 3.6.3.54 4.779e-257 817.0
TLS2_k127_390875_1 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001966 258.0
TLS2_k127_390875_2 Metal-sensitive transcriptional repressor K21600 - - 0.00000000000000000000000001499 111.0
TLS2_k127_390875_3 Heavy-metal-associated domain - - - 0.00000000000002637 75.0
TLS2_k127_390875_4 Parallel beta-helix repeats - - - 0.00000000001669 76.0
TLS2_k127_3911511_0 helix_turn_helix, Lux Regulon K03556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007037 503.0
TLS2_k127_3911511_1 response regulator K07689 - - 0.000004217 51.0
TLS2_k127_3927306_0 PFAM oxidoreductase domain protein - - - 2.721e-216 675.0
TLS2_k127_3927306_1 AP endonuclease family 2 C terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006434 586.0
TLS2_k127_3927306_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000576 442.0
TLS2_k127_3927306_3 Belongs to the ABC transporter superfamily K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008774 369.0
TLS2_k127_3927306_4 TOBE domain K17324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 356.0
TLS2_k127_3927306_5 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 329.0
TLS2_k127_3927306_6 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009865 298.0
TLS2_k127_3927306_7 Binding-protein-dependent transport system inner membrane component K02026,K10229 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001294 265.0
TLS2_k127_3927306_8 Binding-protein-dependent transport system inner membrane component K02025,K10228 - - 0.00000000000000000000000000000000000000001972 155.0
TLS2_k127_3945324_0 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004268 290.0
TLS2_k127_3945324_1 - - - - 0.0000000000000000000000000000000000000000000000000000001501 214.0
TLS2_k127_3945324_2 Protein of unknown function (DUF1616) - - - 0.000000000000000000000002394 110.0
TLS2_k127_3960424_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 470.0
TLS2_k127_3960424_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 407.0
TLS2_k127_3960424_2 ATP:ADP antiporter activity K15762 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 363.0
TLS2_k127_3960424_3 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287,K18590 - 1.5.1.3 0.00000000000000000000000000000000000000000000000000007895 190.0
TLS2_k127_397246_0 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000039 276.0
TLS2_k127_397246_1 ABC transporter (Permease K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002203 280.0
TLS2_k127_397246_2 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001621 253.0
TLS2_k127_397246_3 ATPases associated with a variety of cellular activities K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001129 246.0
TLS2_k127_397246_4 ABC transporter K01996 - - 0.000000000000000000000000000002245 121.0
TLS2_k127_3975196_0 FAD linked oxidase domain protein K00103,K16653 GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010383,GO:0016020,GO:0016051,GO:0031221,GO:0033692,GO:0034637,GO:0034645,GO:0035884,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0070589,GO:0070592,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901576 1.1.3.8,1.1.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003464 536.0
TLS2_k127_3975196_1 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 380.0
TLS2_k127_3975196_10 Plasmid maintenance system killer - - - 0.000000000000000000000000007513 113.0
TLS2_k127_3975196_11 acyltransferase K00655 - 2.3.1.51 0.00000000000000003452 91.0
TLS2_k127_3975196_2 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 326.0
TLS2_k127_3975196_3 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 306.0
TLS2_k127_3975196_4 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 289.0
TLS2_k127_3975196_5 Cytidine and deoxycytidylate deaminase zinc-binding region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001046 276.0
TLS2_k127_3975196_6 periplasmic protein (DUF2233) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005543 273.0
TLS2_k127_3975196_7 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000009488 240.0
TLS2_k127_3975196_8 PFAM Patatin K07001 - - 0.0000000000000000000000000000000000000000000000000000000003631 216.0
TLS2_k127_3975196_9 PFAM Prenyltransferase squalene oxidase - - - 0.000000000000000000000000000000000000000000008364 172.0
TLS2_k127_3988191_0 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.0 1202.0
TLS2_k127_3988191_1 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 2.238e-216 680.0
TLS2_k127_3988191_2 PFAM glycosyl transferase, family 51 - - - 1.618e-194 635.0
TLS2_k127_3988191_3 Cysteine-rich domain K18928 - - 0.00000000000000000000000000000000000000000000000000000000002158 214.0
TLS2_k127_3988191_4 NTF2-like N-terminal transpeptidase domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000064 171.0
TLS2_k127_3988191_5 mRNA catabolic process K06950 - - 0.00000000000000000000000000000004135 135.0
TLS2_k127_3988191_6 - - - - 0.00000000000000176 80.0
TLS2_k127_3988191_7 Phage derived protein Gp49-like (DUF891) - - - 0.00001196 50.0
TLS2_k127_3995783_0 Histidine kinase K07646 - 2.7.13.3 1.228e-239 762.0
TLS2_k127_3995783_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000001834 232.0
TLS2_k127_4005280_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - - 8.45e-208 661.0
TLS2_k127_4005280_1 ATP synthesis coupled electron transport K00342,K00343,K05568 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005867 492.0
TLS2_k127_4005280_10 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000002165 107.0
TLS2_k127_4005280_12 N-Acetylmuramoyl-L-alanine amidase - - - 0.000000001082 71.0
TLS2_k127_4005280_2 Peptidase family S58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006227 428.0
TLS2_k127_4005280_3 Belongs to the ABC transporter superfamily K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004788 347.0
TLS2_k127_4005280_4 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 332.0
TLS2_k127_4005280_5 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005185 287.0
TLS2_k127_4005280_6 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000462 285.0
TLS2_k127_4005280_7 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001818 269.0
TLS2_k127_4005280_8 WD40-like Beta Propeller Repeat K03641 - - 0.000000000000000000000000000000000000000000004632 181.0
TLS2_k127_4005280_9 Multisubunit Na H antiporter MnhC subunit K00340,K05567 - 1.6.5.3 0.000000000000000000000001933 107.0
TLS2_k127_4013832_0 transmembrane transport K02025,K10118,K15771 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 298.0
TLS2_k127_4013832_1 PFAM extracellular solute-binding protein family 1 K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001311 270.0
TLS2_k127_4013832_2 PFAM glycoside hydrolase family 65 central catalytic - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001094 252.0
TLS2_k127_4020176_0 PFAM Cytochrome C assembly protein K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009227 457.0
TLS2_k127_4020176_1 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000002414 75.0
TLS2_k127_4033881_0 PFAM glycoside hydrolase family 39 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007345 405.0
TLS2_k127_4033881_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000912 400.0
TLS2_k127_4033881_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 388.0
TLS2_k127_4033881_3 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000825 231.0
TLS2_k127_4033881_4 cell envelope-related transcriptional attenuator - - - 0.000000000000000000000000000000000000000000000000000000004962 213.0
TLS2_k127_4033881_5 - - - - 0.00000000000000000000000000000000000000000002238 171.0
TLS2_k127_4046347_0 Type III restriction enzyme res subunit - - - 0.0000000000008776 80.0
TLS2_k127_4050182_0 Trehalose synthase K05343 - 3.2.1.1,5.4.99.16 9.763e-215 679.0
TLS2_k127_4050182_1 ABC-type sugar transport system, permease component K10234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 464.0
TLS2_k127_4050182_2 transmembrane transport K02025,K10233,K15771 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 302.0
TLS2_k127_4050794_0 Tail Collar domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008475 265.0
TLS2_k127_4050794_1 Phage Tail Collar Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007161 254.0
TLS2_k127_4050794_2 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000003097 163.0
TLS2_k127_4050794_3 - - - - 0.000000000000001298 80.0
TLS2_k127_4051222_0 Belongs to the GcvT family K00302 - 1.5.3.1 1.076e-245 790.0
TLS2_k127_4051222_1 FAD dependent oxidoreductase K00303 - 1.5.3.1 2.591e-195 615.0
TLS2_k127_4051222_10 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00007189 53.0
TLS2_k127_4051222_2 Protein of unknown function (DUF1638) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000159 258.0
TLS2_k127_4051222_3 alcohol dehydrogenase K13954 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000001061 259.0
TLS2_k127_4051222_4 NUDIX domain - - - 0.000000000000000000000000000000000000007225 152.0
TLS2_k127_4051222_5 Peptidase C26 K01951 - 6.3.5.2 0.0000000000000000000000000000000000002183 149.0
TLS2_k127_4051222_6 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.000000000000000000000000000003275 124.0
TLS2_k127_4051222_7 Sarcosine oxidase, delta subunit family K00304 - 1.5.3.1 0.00000000000000008377 83.0
TLS2_k127_4051222_8 DinB family - - - 0.0000000000000007239 85.0
TLS2_k127_4062826_0 - - - - 0.000000000000000001365 100.0
TLS2_k127_4070605_0 inositol monophosphate 1-phosphatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000988 440.0
TLS2_k127_4070605_1 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 292.0
TLS2_k127_4070605_2 secretion protein HlyD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002648 262.0
TLS2_k127_4070605_3 Predicted membrane protein (DUF2231) - - - 0.0000000000004708 69.0
TLS2_k127_4073076_0 Transposase IS116/IS110/IS902 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 419.0
TLS2_k127_4073076_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 347.0
TLS2_k127_4073076_2 - - - - 0.000000000000000000000000000000116 134.0
TLS2_k127_4073076_3 COG4644 Transposase and inactivated derivatives TnpA family - - - 0.000000000000000000000003278 104.0
TLS2_k127_4083150_0 SMART LamG domain protein jellyroll fold domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001223 273.0
TLS2_k127_4083150_1 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000006022 110.0
TLS2_k127_4088217_0 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 435.0
TLS2_k127_4088217_1 Peptidoglycan-binding lysin domain - - - 0.00007396 53.0
TLS2_k127_4088217_2 ABC-2 family transporter protein - - - 0.0001746 48.0
TLS2_k127_4089653_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 1.69e-249 788.0
TLS2_k127_4089653_1 PFAM OsmC family protein K04063 - - 0.000000000000000000000000000000000000000000000000003504 184.0
TLS2_k127_4099714_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 498.0
TLS2_k127_4099714_1 transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 453.0
TLS2_k127_4099714_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 397.0
TLS2_k127_4099714_3 exodeoxyribonuclease I activity - - - 0.0000000000000000000000000000000000000009689 154.0
TLS2_k127_4099714_4 Belongs to the glycosyl hydrolase 26 family K01179,K01218 - 3.2.1.4,3.2.1.78 0.0000000000000000000000000000002386 142.0
TLS2_k127_410059_0 AAA ATPase domain - - - 2.673e-210 704.0
TLS2_k127_410059_1 periplasmic ligand-binding sensor domain - - - 0.000000000000000000000000000004236 136.0
TLS2_k127_4106999_0 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 1.741e-199 634.0
TLS2_k127_4106999_1 PFAM ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007452 282.0
TLS2_k127_4106999_2 translation release factor activity K03265 - - 0.000000000000000000000000000000000000000000000000000000000000000000006675 248.0
TLS2_k127_4106999_3 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000002621 226.0
TLS2_k127_4106999_4 Polysaccharide biosynthesis protein K15856 - 1.1.1.281 0.000000000000000000000000000000000000000000000000000000000000004322 231.0
TLS2_k127_4106999_5 Subtilase family - - - 0.0000000000000000000000000000000000002789 151.0
TLS2_k127_4106999_6 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.0000000000385 65.0
TLS2_k127_4109844_0 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 1.577e-244 777.0
TLS2_k127_4109844_1 Glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009244 297.0
TLS2_k127_4109844_2 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000000000000000002499 234.0
TLS2_k127_4110831_0 ABC transporter transmembrane region K06147,K06148 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006489 572.0
TLS2_k127_4110831_1 COGs COG1132 ABC-type multidrug transport system ATPase and permease components K06147 - - 0.000000000000000000003394 100.0
TLS2_k127_4116430_0 Belongs to the PEP-utilizing enzyme family K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 1.359e-223 719.0
TLS2_k127_4116430_1 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 2.114e-200 638.0
TLS2_k127_4116430_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00113 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003495 487.0
TLS2_k127_4116430_3 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00112 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 353.0
TLS2_k127_4116430_4 Glycerol metabolism operon regulatory protein K05880 GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000002566 192.0
TLS2_k127_4116430_5 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.00000000000000000000004577 98.0
TLS2_k127_4118203_0 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005448 274.0
TLS2_k127_4118203_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000002943 137.0
TLS2_k127_4118203_2 HsdM N-terminal domain K03427 - 2.1.1.72 0.00000000000000000000004746 99.0
TLS2_k127_4125624_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299,K03281 - 3.4.17.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006755 541.0
TLS2_k127_4125624_1 COG0675 Transposase and inactivated derivatives - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 498.0
TLS2_k127_4125624_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000002452 244.0
TLS2_k127_4125624_3 Transposase K07491 - - 0.0000000000000000000000000000000000000000004701 160.0
TLS2_k127_4125624_4 JAB1/Mov34/MPN/PAD-1 ubiquitin protease - - - 0.000000000000000000000001117 108.0
TLS2_k127_4126281_0 domain protein K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004371 425.0
TLS2_k127_4126281_1 Large extracellular alpha-helical protein - - - 0.0001184 56.0
TLS2_k127_4137428_0 Ferritin-like domain K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000002068 235.0
TLS2_k127_4137428_1 Domain of unknown function (DUF4872) - - - 0.0000000000000000000000000000000000000000000000000000001352 203.0
TLS2_k127_4137428_2 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000009968 155.0
TLS2_k127_4137428_3 Zn_pept - - - 0.00000000000000000000000000002259 135.0
TLS2_k127_4137428_4 CarboxypepD_reg-like domain K13276 - - 0.000000000000000009638 98.0
TLS2_k127_4137428_5 - - - - 0.0001447 52.0
TLS2_k127_4139455_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005817 441.0
TLS2_k127_4139455_1 PFAM secretion protein HlyD family protein K02004,K06218,K16552 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005519 274.0
TLS2_k127_4139455_2 histidine kinase A domain protein K02482 - 2.7.13.3 0.0000000000000000000000000006867 126.0
TLS2_k127_4139455_3 histone H2A K63-linked ubiquitination - - - 0.00009891 54.0
TLS2_k127_4151823_0 Aldehyde oxidase and xanthine dehydrogenase a b hammerhead K03520,K11177 - 1.17.1.4,1.2.5.3 2.323e-300 942.0
TLS2_k127_4151823_1 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000009226 239.0
TLS2_k127_4151823_2 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000927 247.0
TLS2_k127_4151823_3 PFAM Ethyl tert-butyl ether degradation EthD - - - 0.0000000000000000000002763 102.0
TLS2_k127_4151823_4 PFAM carbon monoxide dehydrogenase subunit G K09386 - - 0.0000006764 55.0
TLS2_k127_4156361_0 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.00000000000000000000000000000000000000000000000000001767 194.0
TLS2_k127_4156361_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000289 166.0
TLS2_k127_4156361_2 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000001969 145.0
TLS2_k127_4173568_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 1.647e-267 852.0
TLS2_k127_4173568_1 nuclease activity K07062 - - 0.0000000000000000000000000000000007235 134.0
TLS2_k127_4173568_2 - - - - 0.0000000000000000000000000008708 116.0
TLS2_k127_4216077_0 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.0 1170.0
TLS2_k127_4216962_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001794 293.0
TLS2_k127_4216962_1 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000001018 211.0
TLS2_k127_4216962_2 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - 0.0000000000000000000000000000000000000000000000000000000003389 223.0
TLS2_k127_422016_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009604 538.0
TLS2_k127_422016_1 PFAM aminotransferase class V K04127 - 5.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003992 437.0
TLS2_k127_422016_10 Extracellular nuclease - - - 0.00000000000000000001052 107.0
TLS2_k127_422016_11 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000002525 55.0
TLS2_k127_422016_12 Asp23 family, cell envelope-related function - - - 0.00000004449 59.0
TLS2_k127_422016_13 GDP-mannose mannosyl hydrolase activity - - - 0.0000004049 57.0
TLS2_k127_422016_14 SpoVT / AbrB like domain - - - 0.0000007937 54.0
TLS2_k127_422016_15 Sortase family - - - 0.000006451 58.0
TLS2_k127_422016_2 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 443.0
TLS2_k127_422016_3 modification enzyme, MiaB family K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 410.0
TLS2_k127_422016_4 cytochrome p450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 344.0
TLS2_k127_422016_5 COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003121 271.0
TLS2_k127_422016_6 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000003188 266.0
TLS2_k127_422016_7 TIGRFAM conserved repeat domain - - - 0.0000000000000000000000000000000000000000000000000000000009447 219.0
TLS2_k127_422016_8 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000000000000003728 158.0
TLS2_k127_422016_9 - - - - 0.000000000000000000000000000000000000001284 164.0
TLS2_k127_4234065_0 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 548.0
TLS2_k127_4234065_1 Protein kinase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 381.0
TLS2_k127_4234065_2 Histidine kinase - - - 0.0000000000000000000000000000000000000005211 170.0
TLS2_k127_4234065_3 metallocarboxypeptidase activity K05996 - 3.4.17.18 0.0000000001651 74.0
TLS2_k127_4236654_0 TIGRFAM phenylacetate-CoA oxygenase, PaaG subunit K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000374 510.0
TLS2_k127_4236654_1 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 291.0
TLS2_k127_4236654_2 phenylacetic acid degradation K02610 - - 0.00000000000000000000000000000000000000005269 157.0
TLS2_k127_4239403_0 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 474.0
TLS2_k127_4239403_1 Protein of unknown function, DUF - - - 0.000000000000000000000000000000000000000001375 161.0
TLS2_k127_4239403_2 transcriptional regulator - - - 0.00000000000000000000000000000000000000007931 158.0
TLS2_k127_4241736_0 Propeptide_C25 - - - 0.00000000000000000000000000000000000000002315 176.0
TLS2_k127_4241736_1 YceI-like domain - - - 0.00004309 55.0
TLS2_k127_4246459_0 Cadherin repeats. - - - 0.0000000000000000000000000000000000000000000000000000000000000000009397 248.0
TLS2_k127_4246459_1 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K01163,K03790 - 2.3.1.128 0.000003085 57.0
TLS2_k127_4260067_0 PFAM peptidase M20 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004799 563.0
TLS2_k127_4260067_1 hydroxymethylglutaryl-CoA reductase (NADPH) activity K00021 - 1.1.1.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 540.0
TLS2_k127_4260067_2 Belongs to the phosphoglycerate mutase family - - - 0.0000000000000000000000000000000000000004271 156.0
TLS2_k127_4260067_3 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000000000000000000519 98.0
TLS2_k127_4260067_4 Transposase K07496 - - 0.00000000000000034 81.0
TLS2_k127_4260338_0 leucyl-tRNA aminoacylation K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 2.96e-264 836.0
TLS2_k127_4260338_1 Domain of unknown function DUF87 K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004945 563.0
TLS2_k127_4260338_10 alpha-L-arabinofuranosidase - - - 0.000000000000000000000002177 119.0
TLS2_k127_4260338_11 Methyltransferase domain - - - 0.0000000000000000000007158 104.0
TLS2_k127_4260338_12 C-terminal four TMM region of protein-O-mannosyltransferase - - - 0.00000000000000002508 95.0
TLS2_k127_4260338_3 ATPases associated with a variety of cellular activities K01990,K09689,K09691 - 3.6.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 379.0
TLS2_k127_4260338_4 Methyltransferase domain K06983 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 310.0
TLS2_k127_4260338_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005627 272.0
TLS2_k127_4260338_6 Zn peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000189 249.0
TLS2_k127_4260338_7 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000000000000000000000008486 231.0
TLS2_k127_4260338_8 alpha-L-arabinofuranosidase - - - 0.0000000000000000000000000000000000000000000000000407 198.0
TLS2_k127_4260338_9 Parallel beta-helix repeats - - - 0.000000000000000000000000000004318 134.0
TLS2_k127_4264407_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 414.0
TLS2_k127_4264407_1 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 327.0
TLS2_k127_4264867_0 Oligopeptidase F K08602 - - 1.817e-245 773.0
TLS2_k127_4264867_1 Homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 1.364e-218 695.0
TLS2_k127_4264867_2 Thiol oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 490.0
TLS2_k127_4264867_3 PhoQ Sensor - - - 0.00000000000000000003387 105.0
TLS2_k127_4264867_4 Belongs to the glycosyl hydrolase family 6 K01179 - 3.2.1.4 0.000000000000000006239 98.0
TLS2_k127_4272647_0 ABC transporter transmembrane region K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009329 528.0
TLS2_k127_4272647_1 ABC transporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000966 442.0
TLS2_k127_4272647_2 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000003533 150.0
TLS2_k127_4272647_3 SEC-C Motif Domain Protein - - - 0.00003094 54.0
TLS2_k127_4272647_4 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.0001912 48.0
TLS2_k127_4281682_0 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005973 583.0
TLS2_k127_4281682_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007113 500.0
TLS2_k127_4281682_2 peptidase dimerisation domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 358.0
TLS2_k127_4281682_3 TIGRFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 330.0
TLS2_k127_4281682_4 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003402 257.0
TLS2_k127_4281682_5 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000002199 245.0
TLS2_k127_4281682_6 integral membrane protein - - - 0.000000000000000000000000000000002802 143.0
TLS2_k127_4281682_7 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000003503 91.0
TLS2_k127_4281682_9 Metal-sensitive transcriptional repressor K21600 - - 0.00000001266 61.0
TLS2_k127_4302079_0 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 594.0
TLS2_k127_4302079_1 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 451.0
TLS2_k127_4302079_2 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 330.0
TLS2_k127_4302079_3 NAD(P)H quinone oxidoreductase, PIG3 family K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 323.0
TLS2_k127_4302079_4 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000002957 195.0
TLS2_k127_4302079_5 Rhomboid family - - - 0.00000000000000000000000000000004553 135.0
TLS2_k127_4302079_6 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000008876 126.0
TLS2_k127_4302079_7 Kelch repeat-containing protein - - - 0.000000002673 68.0
TLS2_k127_4304665_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 9.64e-251 799.0
TLS2_k127_4304665_1 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000000005834 158.0
TLS2_k127_4304665_2 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000003593 136.0
TLS2_k127_4318111_0 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 360.0
TLS2_k127_4318111_1 Serine/Threonine protein kinases, catalytic domain K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.000000000000000000000000000000000000000000000000001704 209.0
TLS2_k127_4318111_2 PFAM short chain dehydrogenase - - - 0.0000000009504 64.0
TLS2_k127_4329231_0 ATPases associated with a variety of cellular activities K02028,K09972 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 380.0
TLS2_k127_4329231_1 extracellular solute-binding protein, family 3 K09969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 385.0
TLS2_k127_4329231_10 Leucine rich repeats (6 copies) - - - 0.000000000000000000000000000000000000000000001307 190.0
TLS2_k127_4329231_2 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007236 370.0
TLS2_k127_4329231_3 serine-type peptidase activity K08676 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005404 342.0
TLS2_k127_4329231_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 326.0
TLS2_k127_4329231_5 amino acid transport K09970,K09971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008066 284.0
TLS2_k127_4329231_6 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000006196 265.0
TLS2_k127_4329231_7 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000003521 229.0
TLS2_k127_4329231_8 PFAM Calcium calmodulin dependent protein kinase II - - - 0.0000000000000000000000000000000000000000000000003812 179.0
TLS2_k127_4329231_9 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000004048 180.0
TLS2_k127_4348111_0 Zn_pept - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 434.0
TLS2_k127_4348974_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000003617 257.0
TLS2_k127_4348974_1 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000005636 232.0
TLS2_k127_4348974_2 COGs COG0491 Zn-dependent hydrolase including glyoxylase - - - 0.00000000000000000000000000000000000000000000000000000000177 206.0
TLS2_k127_4348974_3 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000000006058 176.0
TLS2_k127_4348974_4 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000003262 155.0
TLS2_k127_4348974_5 response regulator, receiver K07658 - - 0.0000000000000000000000000009764 117.0
TLS2_k127_4348974_6 CAAX protease self-immunity - - - 0.0000000000000000000000009471 117.0
TLS2_k127_4348974_7 WD40 repeat, subgroup - - - 0.00000000000000007075 81.0
TLS2_k127_4352649_0 Subtilase family K17734 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004395 389.0
TLS2_k127_4352649_1 phosphorelay signal transduction system K07667 - - 0.00000000000000000000000000000000000000000000000000000000000002176 222.0
TLS2_k127_4359873_0 transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006459 444.0
TLS2_k127_4359873_1 PFAM FHA domain - - - 0.0000691 53.0
TLS2_k127_4367524_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 6.526e-317 998.0
TLS2_k127_4367524_1 sh3 domain protein K01448,K04771,K08884 - 2.7.11.1,3.4.21.107,3.5.1.28 0.0000000005547 64.0
TLS2_k127_4397987_0 tRNA synthetases class I (C) catalytic domain K01883 - 6.1.1.16 1.005e-198 628.0
TLS2_k127_4397987_1 Domain of unknown function (DUF1932) - - - 0.000000000000000000000000000000000000000000000001884 184.0
TLS2_k127_4397987_2 DinB family - - - 0.0006584 46.0
TLS2_k127_440036_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 342.0
TLS2_k127_440036_1 Diguanylate cyclase, GGDEF domain - - - 0.0000000000000000000000001713 116.0
TLS2_k127_440036_2 TIGRFAM glutaredoxin-like domain protein - - - 0.00000000001764 72.0
TLS2_k127_4404073_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1103.0
TLS2_k127_4404073_1 Heat shock 70 kDa protein K04043 - - 3.727e-272 850.0
TLS2_k127_4404073_2 PFAM sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 428.0
TLS2_k127_4404073_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006648 396.0
TLS2_k127_4404073_4 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008672 374.0
TLS2_k127_4404073_5 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 314.0
TLS2_k127_4404073_6 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 317.0
TLS2_k127_4404073_7 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000000000000000000000000000000000007435 224.0
TLS2_k127_4404073_8 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000003175 144.0
TLS2_k127_4404073_9 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000007733 129.0
TLS2_k127_4406228_0 Pyruvate:ferredoxin oxidoreductase core domain II K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008138 446.0
TLS2_k127_4406228_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009019 358.0
TLS2_k127_4406228_2 PFAM Aminotransferase class I and II K05825 - - 0.000000000000000000000000000000000000000000000000000000165 197.0
TLS2_k127_4406228_3 PFAM 4Fe-4S K00176 - 1.2.7.3 0.000000000000000000003927 96.0
TLS2_k127_4428032_0 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000002574 234.0
TLS2_k127_4428032_1 Haloacid dehalogenase-like hydrolase K07025 - - 0.00000000000000000000004873 106.0
TLS2_k127_4428696_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008774 567.0
TLS2_k127_4428696_1 fructose 1,6-bisphosphate 1-phosphatase activity K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 439.0
TLS2_k127_4428696_10 protein conserved in cyanobacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001129 246.0
TLS2_k127_4428696_11 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000001338 217.0
TLS2_k127_4428696_12 Removes 5-oxoproline from various penultimate amino acid residues except L-proline K01304 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:1901564 3.4.19.3 0.0000000000000000000000000000000000000000000000000000000007182 212.0
TLS2_k127_4428696_13 Peptidoglycan-binding LysM - - - 0.000000000000000000000000000000000000000000000007357 185.0
TLS2_k127_4428696_14 Peptidoglycan-binding LysM - - - 0.00000000000000000000000000000000000000001514 167.0
TLS2_k127_4428696_15 Domain of unknown function (DUF389) - - - 0.0000000000000000000000000000000000000005405 169.0
TLS2_k127_4428696_16 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000008649 158.0
TLS2_k127_4428696_17 Belongs to the CDS family K00981 - 2.7.7.41 0.000000000000000000000000000000000000001666 157.0
TLS2_k127_4428696_18 RNase_H superfamily K07502 - - 0.00000000000000000000000000000000000004669 152.0
TLS2_k127_4428696_19 Hep Hag repeat protein K11904,K21449 - - 0.000000000000000009361 87.0
TLS2_k127_4428696_2 glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000849 376.0
TLS2_k127_4428696_20 hydrolase (metallo-beta-lactamase superfamily) - - - 0.00000000000000009237 88.0
TLS2_k127_4428696_21 CopC domain K14166 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000003278 70.0
TLS2_k127_4428696_23 homoprotocatechuate degradation operon regulator, HpaR' - - - 0.00007484 49.0
TLS2_k127_4428696_3 DNA binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 342.0
TLS2_k127_4428696_4 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 325.0
TLS2_k127_4428696_5 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 311.0
TLS2_k127_4428696_6 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 309.0
TLS2_k127_4428696_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 295.0
TLS2_k127_4428696_8 Phospholipase/Carboxylesterase K06999,K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001368 254.0
TLS2_k127_4428696_9 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - 0.0000000000000000000000000000000000000000000000000000000000000000000000265 246.0
TLS2_k127_4450232_0 ABC transporter - - - 0.0 1212.0
TLS2_k127_4450232_1 histidine kinase, dimerisation and phosphoacceptor region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 372.0
TLS2_k127_4450232_3 Two component transcriptional regulator, LuxR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001129 244.0
TLS2_k127_4450232_4 Phage integrase family - - - 0.0000000000000000000000000000000000000000000005199 181.0
TLS2_k127_4450232_5 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000000000000000000000005229 150.0
TLS2_k127_4450232_6 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000003461 109.0
TLS2_k127_4450232_7 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749,K04757 - 2.7.11.1 0.000000000003408 72.0
TLS2_k127_4450232_8 PFAM blue (type 1) copper domain protein - - - 0.0000000001442 73.0
TLS2_k127_4459995_0 PFAM Rhodanese domain protein - - - 0.0000000000000000000000000000000000000000000002173 171.0
TLS2_k127_4459995_1 Large extracellular alpha-helical protein K06894 - - 0.0000000000000000000000000000000000000000000002582 192.0
TLS2_k127_4459995_2 WD40-like Beta Propeller Repeat K03641 - - 0.0002194 55.0
TLS2_k127_4472319_0 PFAM amidohydrolase K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 451.0
TLS2_k127_4472319_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000001179 244.0
TLS2_k127_4472319_2 Bacterial periplasmic substrate-binding proteins K02030 - - 0.000000000000000000000000000000000000000000000008803 176.0
TLS2_k127_4474093_0 PFAM ABC transporter related K05833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009669 291.0
TLS2_k127_4474093_1 Psort location Cytoplasmic, score K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000002141 254.0
TLS2_k127_4474093_2 PFAM Branched-chain amino acid transport system permease component K05832 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008164 255.0
TLS2_k127_4474093_3 PFAM ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000001488 194.0
TLS2_k127_4474093_4 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000006662 130.0
TLS2_k127_4487082_0 helix_turn_helix, Lux Regulon K03556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 492.0
TLS2_k127_4487082_1 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006178 415.0
TLS2_k127_4487082_2 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0000000000000000000001473 102.0
TLS2_k127_4499176_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009736 265.0
TLS2_k127_4499176_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003809 252.0
TLS2_k127_4499176_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000009567 245.0
TLS2_k127_4499176_3 Domain of unknown function (DUF4162) - - - 0.00000000000000000006548 91.0
TLS2_k127_4499982_0 Tex-like protein N-terminal domain K06959 - - 2.957e-237 745.0
TLS2_k127_4499982_1 bacterial-type flagellum-dependent cell motility - - - 0.000000000000000000000003245 115.0
TLS2_k127_4506017_0 (ABC) transporter K06147 - - 7.361e-225 712.0
TLS2_k127_4514446_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009495 580.0
TLS2_k127_4514446_1 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000005041 261.0
TLS2_k127_4514446_2 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000001344 191.0
TLS2_k127_4518518_0 Family 4 glycosyl hydrolase K07406 - 3.2.1.22 1.466e-221 692.0
TLS2_k127_4518518_1 TIGRFAM galactose-1-phosphate uridylyltransferase K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 493.0
TLS2_k127_4518518_2 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 424.0
TLS2_k127_4518518_3 Putative esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 321.0
TLS2_k127_4518518_4 GDSL-like Lipase/Acylhydrolase family - - - 0.00000001254 58.0
TLS2_k127_4518518_5 - - - - 0.00000001561 61.0
TLS2_k127_4518518_6 - - - - 0.000001175 55.0
TLS2_k127_4524538_0 Belongs to the carbamoyltransferase HypF family K04656 - - 6.631e-264 836.0
TLS2_k127_4524538_1 hydrogenase expression formation protein HypD K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 545.0
TLS2_k127_4524538_2 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 422.0
TLS2_k127_4524538_3 Hydrogenase accessory protein HypB K03189,K04652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 303.0
TLS2_k127_4524538_4 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000006673 124.0
TLS2_k127_4524538_5 Hydrogenase expression formation protein K04653 - - 0.0000000000000000000000023 106.0
TLS2_k127_4524538_6 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.000001946 57.0
TLS2_k127_4531677_0 PFAM sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 499.0
TLS2_k127_4531677_1 PFAM major facilitator superfamily MFS_1 K08161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004734 413.0
TLS2_k127_4531677_10 PAS domain - - - 0.0000002139 57.0
TLS2_k127_4531677_2 PFAM periplasmic binding protein LacI transcriptional regulator K02058,K10439 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 370.0
TLS2_k127_4531677_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006475 317.0
TLS2_k127_4531677_4 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000228 223.0
TLS2_k127_4531677_5 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000001645 183.0
TLS2_k127_4531677_6 Psort location Cytoplasmic, score K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000002407 170.0
TLS2_k127_4531677_7 SCP-2 sterol transfer family - - - 0.0000000000000000000000000000000000001076 146.0
TLS2_k127_4531677_8 -O-antigen K13009,K18814 - - 0.0000000000000000000004936 110.0
TLS2_k127_4531677_9 Histidine kinase K07718 - 2.7.13.3 0.0000000000001522 72.0
TLS2_k127_4547961_0 Domain of unknown function (DUF3524) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009717 363.0
TLS2_k127_4547961_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 308.0
TLS2_k127_4547961_2 Fe-S assembly protein IscX - - - 0.0000008616 54.0
TLS2_k127_455453_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 585.0
TLS2_k127_455453_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000131 102.0
TLS2_k127_455453_2 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000002283 95.0
TLS2_k127_45646_0 PFAM WD domain, G-beta repeat - - - 3.873e-225 756.0
TLS2_k127_45646_1 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000001108 261.0
TLS2_k127_45646_2 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000006344 241.0
TLS2_k127_45646_3 Glycosyl transferase WecB/TagA/CpsF family K05946 - 2.4.1.187 0.000000000000000000000001417 104.0
TLS2_k127_45646_4 -O-antigen K02847,K02849,K21003 - - 0.0000003857 62.0
TLS2_k127_4572393_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.785e-245 769.0
TLS2_k127_4572393_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005862 412.0
TLS2_k127_4572393_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000984 317.0
TLS2_k127_4572393_3 PFAM oxidoreductase, molybdopterin binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 315.0
TLS2_k127_4572393_4 PFAM Roadblock LC7 family protein K07131 - - 0.000000000000000000000000000000000000000000001458 168.0
TLS2_k127_4572393_5 Protein of unknown function (DUF3307) - - - 0.0000000103 60.0
TLS2_k127_4572393_6 - - - - 0.0000001187 61.0
TLS2_k127_457295_0 lyase activity - - - 5e-324 1032.0
TLS2_k127_457295_1 transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 414.0
TLS2_k127_457295_2 tail collar domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003022 308.0
TLS2_k127_457295_3 self proteolysis - - - 0.000000000000000000000000000008438 137.0
TLS2_k127_457295_4 competence protein ComEC K02238 - - 0.0000000041 61.0
TLS2_k127_4584249_0 PFAM Rh family protein ammonium transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 574.0
TLS2_k127_4584249_1 Glutamine synthetase type III K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 346.0
TLS2_k127_4584249_3 Glutamate synthase K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.000000000000000000000000007012 113.0
TLS2_k127_4595225_0 WD40 domain protein beta Propeller K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 310.0
TLS2_k127_4595225_1 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005698 249.0
TLS2_k127_4595225_2 Lipid kinase - - - 0.000000000000000000000000000000000000000000000000000000003424 210.0
TLS2_k127_4595225_3 heme binding - - - 0.0000000000000000000000000000000000000000000000002893 192.0
TLS2_k127_4595225_4 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000156 166.0
TLS2_k127_4595225_5 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 - 0.000000003205 60.0
TLS2_k127_45954_0 Sulfite reductase K00366,K00381,K00392 - 1.7.7.1,1.8.1.2,1.8.7.1 1.029e-302 946.0
TLS2_k127_45954_1 Sodium/hydrogen exchanger family K11105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 533.0
TLS2_k127_45954_2 - - - - 0.00000000000000000002306 98.0
TLS2_k127_45954_3 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000000005511 60.0
TLS2_k127_4598047_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 5.357e-232 738.0
TLS2_k127_4598047_1 Pep-cterm family integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006451 552.0
TLS2_k127_4598047_2 Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000147 283.0
TLS2_k127_4598047_3 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001601 274.0
TLS2_k127_460698_0 transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 577.0
TLS2_k127_460698_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003715 265.0
TLS2_k127_460698_2 ankyrin repeats - - - 0.0000000000000000000000000000002084 132.0
TLS2_k127_460698_4 Immune inhibitor A peptidase M6 K09607 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 - 0.0000000000001049 85.0
TLS2_k127_4611970_0 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.0 2020.0
TLS2_k127_4611970_1 cellulose binding - - - 1.255e-224 698.0
TLS2_k127_4611970_10 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000001446 110.0
TLS2_k127_4611970_12 Polysaccharide biosynthesis protein - - - 0.0000000000000001338 93.0
TLS2_k127_4611970_13 Tricorn protease homolog K08676 - - 0.0007307 51.0
TLS2_k127_4611970_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009718 419.0
TLS2_k127_4611970_3 PFAM PfkB domain protein K00874 - 2.7.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007998 392.0
TLS2_k127_4611970_4 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 336.0
TLS2_k127_4611970_5 2-dehydro-3-deoxyphosphogluconate aldolase K01625 - 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000000000000000000000000001057 201.0
TLS2_k127_4611970_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000007568 187.0
TLS2_k127_4611970_7 Mo-molybdopterin cofactor metabolic process K03636,K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000178 146.0
TLS2_k127_4611970_8 - - - - 0.00000000000000000000000000000000004407 140.0
TLS2_k127_4611970_9 PFAM Forkhead-associated protein - - - 0.000000000000000000000001728 108.0
TLS2_k127_4617148_0 intracellular signal transduction - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 424.0
TLS2_k127_4617148_1 Tetratricopeptide repeat - - - 0.0000007643 61.0
TLS2_k127_4627243_0 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 456.0
TLS2_k127_4627243_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 311.0
TLS2_k127_4627243_2 Alpha-2-macroglobulin family K06894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004902 317.0
TLS2_k127_4627243_3 Rare lipoprotein A K20628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 296.0
TLS2_k127_4627243_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000004507 226.0
TLS2_k127_4627243_6 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000002241 190.0
TLS2_k127_4627243_7 photosynthesis - - - 0.000000000000000000000000000000000000000000000001328 178.0
TLS2_k127_4627243_8 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000004773 116.0
TLS2_k127_466796_0 Sodium:sulfate symporter transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008248 502.0
TLS2_k127_466796_1 TIGRFAM TraB family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009243 428.0
TLS2_k127_466796_2 Major facilitator Superfamily K05386 - - 0.00000000000000000000000000000000000000000000000000000000005027 230.0
TLS2_k127_466796_3 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000000001126 212.0
TLS2_k127_466796_4 PFAM Citrate transporter - - - 0.00000000000000000000005244 99.0
TLS2_k127_466796_5 DNA-binding transcriptional activator of the SARP family - - - 0.00001792 57.0
TLS2_k127_4674711_0 PFAM NADH Ubiquinone plastoquinone (complex I) K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 540.0
TLS2_k127_4674711_1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05560,K05567 - - 0.000000000000000000000000000000000000000000008079 165.0
TLS2_k127_4674711_2 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.0000000000000000000000000000000000000000003663 163.0
TLS2_k127_4674711_3 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit K05559,K05565 GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - 0.0000000000000000000006487 97.0
TLS2_k127_4685983_0 PFAM IstB domain protein ATP-binding protein K02315 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 450.0
TLS2_k127_4685983_1 TIGRFAM primosome, DnaD subunit - - - 0.00000000000000000000000000000000000000000000000000000000000008659 220.0
TLS2_k127_4685983_2 Peptidoglycan binding domain - - - 0.00000006961 61.0
TLS2_k127_469494_0 TIGRFAM phenylalanyl-tRNA synthetase, beta subunit K01890 - 6.1.1.20 1.994e-216 698.0
TLS2_k127_469494_1 alpha beta hydrolase superfamily K01055 - 3.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006867 273.0
TLS2_k127_469494_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000004484 131.0
TLS2_k127_469494_3 Protein of unknown function, DUF624 - - - 0.0000001048 61.0
TLS2_k127_470153_0 PFAM FAD dependent oxidoreductase K09471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 449.0
TLS2_k127_470153_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 407.0
TLS2_k127_470153_10 PFAM Forkhead-associated protein - - - 0.00000000000000000881 95.0
TLS2_k127_470153_12 PFAM YhhN family protein - - - 0.00000004247 56.0
TLS2_k127_470153_13 domain, Protein K08961 - 4.2.2.20,4.2.2.21 0.000009517 58.0
TLS2_k127_470153_2 Psort location Cytoplasmic, score 8.87 K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 375.0
TLS2_k127_470153_3 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008101 303.0
TLS2_k127_470153_4 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003876 278.0
TLS2_k127_470153_5 Binding-protein-dependent transport system inner membrane component K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001969 269.0
TLS2_k127_470153_6 PFAM adenylyl cyclase class-3 4 guanylyl cyclase K01768,K01769,K07315,K18967 - 2.7.7.65,3.1.3.3,4.6.1.1,4.6.1.2 0.000000000000000000000000000000000000000000001423 191.0
TLS2_k127_470153_7 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000008513 162.0
TLS2_k127_470153_8 sequence-specific DNA binding K03718 - - 0.000000000000000000000000000000004157 134.0
TLS2_k127_470153_9 Transposase IS200 like - - - 0.0000000000000000000000000000001615 135.0
TLS2_k127_4701768_0 SMART Animal peptidoglycan recognition protein PGRP - - - 0.0000000000000000000000000000000000000000000000000000000000000006045 245.0
TLS2_k127_4701768_1 TIGRFAM geranylgeranyl reductase K10960 - 1.3.1.111,1.3.1.83 0.000000000000000000000000000000000002031 153.0
TLS2_k127_471381_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 1.026e-236 742.0
TLS2_k127_471381_1 PFAM oxidoreductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 465.0
TLS2_k127_471381_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006244 366.0
TLS2_k127_471381_3 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000003062 194.0
TLS2_k127_4715434_0 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 427.0
TLS2_k127_4715434_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 420.0
TLS2_k127_4715434_2 Response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 323.0
TLS2_k127_4715434_3 COG3221 ABC-type phosphate phosphonate transport system, periplasmic component K02044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006975 273.0
TLS2_k127_4715434_4 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000009156 226.0
TLS2_k127_4715434_5 integral membrane protein K07027 - - 0.000000006608 67.0
TLS2_k127_4715434_6 glycosyl transferase, family 39 - - - 0.000001777 55.0
TLS2_k127_4724524_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.171e-271 849.0
TLS2_k127_4724524_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000002451 70.0
TLS2_k127_472574_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 5.422e-284 888.0
TLS2_k127_472574_1 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007017 418.0
TLS2_k127_472574_2 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.000000000000000000000000000000000000000000000000000000001188 207.0
TLS2_k127_472574_3 Domain of unknown function (DUF4129) - - - 0.00000000000000000004792 98.0
TLS2_k127_472574_4 Domain of unknown function (DUF4350) - - - 0.00000000000001843 85.0
TLS2_k127_4742148_0 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 599.0
TLS2_k127_4742148_1 Cellulose biosynthesis protein BcsQ K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007071 303.0
TLS2_k127_4742148_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000001133 159.0
TLS2_k127_4742148_3 Aldo Keto reductase - - - 0.0000000000004479 70.0
TLS2_k127_4742235_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006577 494.0
TLS2_k127_4742235_1 SMART Nucleotide binding protein, PINc - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008182 357.0
TLS2_k127_4745704_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 419.0
TLS2_k127_4760730_0 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000469 427.0
TLS2_k127_4760730_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 359.0
TLS2_k127_4760730_2 peptidase activity - - - 0.000000000000000000000000000000000000000000000000001929 195.0
TLS2_k127_4760730_3 DinB superfamily - - - 0.00000000000000000000000000000000000000000002403 171.0
TLS2_k127_4760730_4 Zincin-like metallopeptidase - - - 0.00000000000000000000000003852 108.0
TLS2_k127_4761243_0 PFAM sugar isomerase (SIS) K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 340.0
TLS2_k127_4761243_1 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002989 273.0
TLS2_k127_4761243_2 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000009329 143.0
TLS2_k127_4777288_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829,K19969,K21342 - 2.7.1.71,4.2.3.152,4.2.3.154,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 376.0
TLS2_k127_4777288_1 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 340.0
TLS2_k127_4777288_2 Belongs to the 'phage' integrase family K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003142 285.0
TLS2_k127_4777288_3 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000002606 205.0
TLS2_k127_4777288_4 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000000000000000000000001153 169.0
TLS2_k127_4777288_5 Protein of unknown function (DUF3592) - - - 0.00000000000000007271 88.0
TLS2_k127_4781202_0 Gaf domain K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 595.0
TLS2_k127_4781202_1 dipeptide transport K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005167 434.0
TLS2_k127_4781202_2 NUBPL iron-transfer P-loop NTPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 319.0
TLS2_k127_4781202_3 NUBPL iron-transfer P-loop NTPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000329 234.0
TLS2_k127_4781202_4 NUBPL iron-transfer P-loop NTPase - - - 0.00000000000000000000000000000000000000000000000000000003568 200.0
TLS2_k127_4782137_0 PFAM glycosyl transferase family 39 K14340 - - 0.00000000000000000000000000000000000000000001023 181.0
TLS2_k127_4782137_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000003544 95.0
TLS2_k127_4793652_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005047 276.0
TLS2_k127_4793652_1 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003765 273.0
TLS2_k127_4793652_2 PFAM ABC-2 type transporter K09690 - - 0.0000000000000000000000000000000000000000000000000000000000000002304 230.0
TLS2_k127_4793652_3 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000000000000000000000000000000000000000001151 222.0
TLS2_k127_4793652_4 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.00000000000000000000000000000000000000000000000005481 194.0
TLS2_k127_4793652_5 cell envelope-related transcriptional attenuator - - - 0.00000000000000000000000000000000000000001069 172.0
TLS2_k127_4793652_6 Flavin reductase like domain - - - 0.0000000000000000000000000000006774 129.0
TLS2_k127_4793652_7 RF-1 domain K15034 - - 0.000000000000000000000000000638 118.0
TLS2_k127_4793652_8 PIN domain - - - 0.00009244 50.0
TLS2_k127_4793652_9 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0003772 48.0
TLS2_k127_4797535_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 5.054e-263 837.0
TLS2_k127_4797535_1 PFAM glycoside hydrolase family 39 - - - 0.0000000000000000000000000000000000000000000000000000000000000009544 235.0
TLS2_k127_4797535_2 Baseplate J-like protein K01218 - 3.2.1.78 0.0000000000000000000000000000000000000096 163.0
TLS2_k127_4797535_3 LVIVD repeat - - - 0.00008302 54.0
TLS2_k127_4798030_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000001272 250.0
TLS2_k127_4798030_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000003747 202.0
TLS2_k127_4798030_2 oligosaccharyl transferase activity K07151 - 2.4.99.18 0.00000000000000000000000000000000000001429 162.0
TLS2_k127_4798030_3 LVIVD repeat - - - 0.0000000000000001724 83.0
TLS2_k127_4799911_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 7.66e-302 959.0
TLS2_k127_4799911_1 PIN domain - - - 0.00000000000000000000000000000000000000000000000000000000001462 209.0
TLS2_k127_4799911_2 Transcription elongation factor, N-terminal K03624 - - 0.0000000000000000000000000000000000938 138.0
TLS2_k127_4799911_3 PFAM alpha beta hydrolase fold K03928 - 3.1.1.1 0.00000000000000000000000000000001765 138.0
TLS2_k127_4799911_4 nUDIX hydrolase - - - 0.0000000000000000000000000002644 121.0
TLS2_k127_4799911_5 - - - - 0.000000000000000000000006912 102.0
TLS2_k127_4799911_6 phosphinothricin N-acetyltransferase activity - - - 0.0000000000001795 71.0
TLS2_k127_4816523_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 1.078e-195 625.0
TLS2_k127_4816523_1 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000001423 213.0
TLS2_k127_4816523_2 thiolester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000001049 191.0
TLS2_k127_4820744_0 protein-(glutamine-N5) methyltransferase activity - - - 0.000000000000000000000000000000000000000000000005194 176.0
TLS2_k127_4820744_1 Domain of unknown function (DUF4395) - - - 0.0000000000000009519 82.0
TLS2_k127_4820744_2 - - - - 0.00000000003904 68.0
TLS2_k127_4822944_0 Putative transposase DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 295.0
TLS2_k127_4822944_1 Cysteine synthase K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 290.0
TLS2_k127_4822944_2 ROK family K00845,K00886 - 2.7.1.2,2.7.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000006566 261.0
TLS2_k127_4822944_3 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000000000000000000000000008424 235.0
TLS2_k127_4822944_4 peptidyl-tyrosine sulfation K00525,K01768 - 1.17.4.1,4.6.1.1 0.00000000000000000000000000000000000000000000000001421 190.0
TLS2_k127_4822944_5 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000001514 156.0
TLS2_k127_4822944_7 response regulator receiver - - - 0.0000000000000000001113 90.0
TLS2_k127_4830797_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005509 313.0
TLS2_k127_4830797_1 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006183 286.0
TLS2_k127_4835050_0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K09065 - 2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 556.0
TLS2_k127_4835050_1 Pyridoxal-phosphate dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008743 537.0
TLS2_k127_4835050_2 TIGRFAM threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 411.0
TLS2_k127_4835050_3 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000000000000000009677 204.0
TLS2_k127_4835050_4 TIGRFAM threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000001516 181.0
TLS2_k127_4835050_5 GDP-mannose mannosyl hydrolase activity - - - 0.000000000000000461 84.0
TLS2_k127_4847043_0 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006033 546.0
TLS2_k127_4847043_1 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004628 450.0
TLS2_k127_4847043_2 DNA methylAse - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003434 323.0
TLS2_k127_4847043_3 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001559 276.0
TLS2_k127_4847043_4 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000129 253.0
TLS2_k127_4847043_5 YCII-related domain - - - 0.00000000000000000000000387 105.0
TLS2_k127_4847043_6 Lysin motif - - - 0.00006901 54.0
TLS2_k127_4854284_0 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE - - - 0.000000000000000000000000000000000000000000000000000000000000000000001529 236.0
TLS2_k127_4854284_1 Fibronectin type 3 domain - - - 0.00000000000000004648 94.0
TLS2_k127_4854284_2 Zn_pept - - - 0.00000000000001477 81.0
TLS2_k127_4862154_0 bacterial-type flagellum-dependent cell motility - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 489.0
TLS2_k127_4862154_1 PFAM sigma-70 region 2 domain protein K03088 - - 0.0000000000000000006405 91.0
TLS2_k127_4876751_0 AAA ATPase domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 546.0
TLS2_k127_4876751_1 hydroxymethylglutaryl-CoA reductase K00021 - 1.1.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 293.0
TLS2_k127_4876751_2 Alanine-glyoxylate amino-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003576 279.0
TLS2_k127_4876751_3 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K00177 - 1.2.7.1,1.2.7.3 0.00000000000000000000000000000000000000000000000001572 184.0
TLS2_k127_4876751_4 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000000000000000000002596 171.0
TLS2_k127_4876751_5 Domain of unknown function (DUF4367) - - - 0.00004016 55.0
TLS2_k127_4881117_0 Protein of unknown function (DUF2662) - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.00000002365 59.0
TLS2_k127_4881117_1 - - - - 0.00006846 54.0
TLS2_k127_4884669_0 carbohydrate transport K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 426.0
TLS2_k127_4884669_1 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006474 290.0
TLS2_k127_4884669_2 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001352 269.0
TLS2_k127_4922037_0 Alpha-amylase domain K01208 - 3.2.1.133,3.2.1.135,3.2.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 489.0
TLS2_k127_4922037_1 ATPase family associated with various cellular activities (AAA) K03696 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 375.0
TLS2_k127_4922037_2 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 353.0
TLS2_k127_4922037_3 COGs COG1253 Hemolysins and related protein containing CBS domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 334.0
TLS2_k127_493816_0 alpha-L-arabinofuranosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 515.0
TLS2_k127_493816_1 Putative serine dehydratase domain K20757 - 4.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007459 359.0
TLS2_k127_493816_2 Cysteine-rich secretory protein family - - - 0.000000000000000000000000000000000000000128 165.0
TLS2_k127_493816_3 Lactonase, 7-bladed beta-propeller - - - 0.0000000000004788 82.0
TLS2_k127_493816_4 Tricorn protease homolog K08676 - - 0.00000002266 63.0
TLS2_k127_493816_5 Bacterial SH3 domain homologues - - - 0.0009435 52.0
TLS2_k127_4940777_0 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 390.0
TLS2_k127_4940777_1 - - - - 0.000000000000005557 78.0
TLS2_k127_4945676_0 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 413.0
TLS2_k127_4945676_1 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002095 259.0
TLS2_k127_4963283_0 Carboxyl transferase domain K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 2.714e-223 703.0
TLS2_k127_4963283_1 Phosphoribulokinase / Uridine kinase family K00876 - 2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003799 546.0
TLS2_k127_4963283_2 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 326.0
TLS2_k127_4963283_3 Protein of unknown function (DUF4058) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007696 293.0
TLS2_k127_4963283_4 - - - - 0.000000000000000000000000000000000003186 146.0
TLS2_k127_4963283_5 Aminoacyl-tRNA editing domain - - - 0.0000000000000000000000005259 111.0
TLS2_k127_4963283_6 PFAM Lytic transglycosylase catalytic - - - 0.00000000009668 73.0
TLS2_k127_4978803_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000002948 227.0
TLS2_k127_4978803_1 organic phosphonate transmembrane transporter activity K02042 - - 0.0000000000000000000000000000000000000000000000000006927 199.0
TLS2_k127_4978803_2 Cold shock K03704 - - 0.0000000000000000000000007537 104.0
TLS2_k127_4978803_3 sh3 domain protein - - - 0.0000000000007469 76.0
TLS2_k127_4987177_0 Bacterial regulatory proteins, lacI family K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000009308 234.0
TLS2_k127_4987177_1 - - - - 0.00000000000000000000000000000000000006317 146.0
TLS2_k127_4987177_2 - - - - 0.000000000000000000000000000007955 121.0
TLS2_k127_4987177_3 Pfam Response regulator receiver - - - 0.00000000001153 70.0
TLS2_k127_5011694_0 Protein of unknown function (DUF998) - - - 0.000000000000000000000000000000000000000000000000000000000000000000007794 241.0
TLS2_k127_5011694_1 pyruvate phosphate dikinase, PEP K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000001422 224.0
TLS2_k127_5011694_2 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000002417 210.0
TLS2_k127_5011694_3 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000002777 147.0
TLS2_k127_5011694_4 PFAM lipopolysaccharide biosynthesis protein - - - 0.000000003838 68.0
TLS2_k127_5011694_5 Sulfotransferase domain - - - 0.000003469 58.0
TLS2_k127_5014330_0 PFAM Cytochrome C assembly protein K02198 - - 0.00000000000000000000000000000000000000000000008498 172.0
TLS2_k127_5014330_1 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.000000000000000000000000000000001319 137.0
TLS2_k127_5014330_2 subunit of a heme lyase K02200 - - 0.0000000000000000000000000000005215 128.0
TLS2_k127_5014330_3 zinc-ribbon domain - - - 0.0002564 48.0
TLS2_k127_5016974_0 cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 398.0
TLS2_k127_5016974_1 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000374 198.0
TLS2_k127_5016974_2 Flp pilus assembly protein CpaB K02279 - - 0.0000000000000000002099 101.0
TLS2_k127_5016974_3 Cytochrome c K02305 - - 0.0000000000001982 75.0
TLS2_k127_5016974_4 TIGRFAM Flp pilus assembly protein CpaB K02279 - - 0.0000000514 65.0
TLS2_k127_5016974_6 septum formation initiator K05589,K13052 - - 0.0001924 49.0
TLS2_k127_5016995_0 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 342.0
TLS2_k127_5016995_1 PFAM glucosamine galactosamine-6-phosphate isomerase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000968 201.0
TLS2_k127_5016995_2 DNA-templated transcription, initiation K03088 - - 0.0000005898 53.0
TLS2_k127_5020608_0 Zinc-uptake complex component A periplasmic K09818 - - 0.00000000000000000000000000000000000000000000000000000000985 212.0
TLS2_k127_5026388_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 492.0
TLS2_k127_5026388_1 PFAM phosphoesterase, RecJ domain protein K07462 - - 0.0000000000000000000000000000000000000000000000000000001069 203.0
TLS2_k127_5026388_2 Superfamily I DNA and RNA - - - 0.00000000000000000000000000000000000000001053 158.0
TLS2_k127_5026499_0 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000005681 248.0
TLS2_k127_5026499_1 histidine kinase, dimerisation and phosphoacceptor region - - - 0.0000000000000000000000000000000003314 153.0
TLS2_k127_5030096_0 PFAM ABC transporter related K02028,K09972 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 328.0
TLS2_k127_5030096_1 Binding-protein-dependent transport system inner membrane component K01284,K02029 - 3.4.15.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006369 295.0
TLS2_k127_5030096_2 Bacterial periplasmic substrate-binding proteins K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003325 241.0
TLS2_k127_5030096_3 Leucine-rich repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000006949 237.0
TLS2_k127_5030096_4 RNA cap guanine-N2 methyltransferase - - - 0.0000000000000000000000000001775 121.0
TLS2_k127_5030096_5 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000006017 101.0
TLS2_k127_5033588_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 3.923e-208 664.0
TLS2_k127_5033588_1 PFAM von Willebrand factor type A K01337 - 3.4.21.50 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 301.0
TLS2_k127_5033588_2 PFAM Endonuclease exonuclease phosphatase K07004 - - 0.00000000000000000000000000001197 136.0
TLS2_k127_5041571_0 PFAM Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 549.0
TLS2_k127_5041571_1 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000926 516.0
TLS2_k127_5041571_2 Two component transcriptional regulator, winged helix family K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 291.0
TLS2_k127_5041571_3 Serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007344 262.0
TLS2_k127_5041571_5 oligosaccharyl transferase activity - - - 0.00000000000000000000000000000000001886 154.0
TLS2_k127_5045230_0 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 431.0
TLS2_k127_5045230_1 addiction module antidote protein HigA K21498 - - 0.0000000000000000000000000000000000000000000000000002481 185.0
TLS2_k127_5045230_2 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00000000000000000000000000000000000000000000000001274 181.0
TLS2_k127_5045230_3 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000000000000000008963 156.0
TLS2_k127_5045230_4 Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol K15520 GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701 2.3.1.189 0.00000004586 64.0
TLS2_k127_5047320_0 Zn-dependent dipeptidase, microsomal dipeptidase K01273,K01274 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000731 305.0
TLS2_k127_5047320_1 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 292.0
TLS2_k127_5047320_2 COG1525 Micrococcal nuclease (thermonuclease) homologs K01174 - 3.1.31.1 0.00000000007549 70.0
TLS2_k127_5047320_3 Peptidoglycan binding domain - - - 0.00000005966 62.0
TLS2_k127_5047463_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000001183 136.0
TLS2_k127_5047463_1 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.0000000000000000003288 100.0
TLS2_k127_5047463_2 PFAM glycosyl transferase group 1 - - - 0.0000000000000000003989 99.0
TLS2_k127_5047463_3 PFAM glycosyl transferase group 1 - - - 0.000000000000000572 90.0
TLS2_k127_5055348_0 4Fe-4S dicluster domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006911 411.0
TLS2_k127_5055348_1 PFAM FAD linked oxidase domain protein K11472 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006706 308.0
TLS2_k127_5055348_2 homoserine transmembrane transporter activity K06600,K06895 - - 0.0000000000000000000000000000000000000000000000000001291 194.0
TLS2_k127_5055348_3 phosphohistidine phosphatase, SixA K08296 - - 0.00000000000000000000000000000000000000001638 158.0
TLS2_k127_5055348_4 4Fe-4S dicluster domain K11473 - - 0.000000000000000000000000000001983 121.0
TLS2_k127_5055348_5 Domain of unknown function (DUF4349) - - - 0.000000000000000000000004086 109.0
TLS2_k127_5058340_0 Bacterial extracellular solute-binding protein K15770 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 468.0
TLS2_k127_5058340_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 387.0
TLS2_k127_5058340_2 N-terminal of TM subunit in PBP-dependent ABC transporters K15771 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 312.0
TLS2_k127_5058340_3 PFAM binding-protein-dependent transport systems inner membrane component K15772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 290.0
TLS2_k127_5058340_4 epimerase dehydratase K00091 - 1.1.1.219 0.00000000000000000000000000000000000000001311 166.0
TLS2_k127_5058340_5 DNA-binding transcription factor activity - - - 0.0000000000000000000614 96.0
TLS2_k127_5058340_6 Alpha-amylase domain K01208 - 3.2.1.133,3.2.1.135,3.2.1.54 0.0001034 49.0
TLS2_k127_5060091_0 PFAM VanW family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 359.0
TLS2_k127_5060091_1 PLD-like domain K17717 - 3.1.4.4 0.00000000000000000000000000000000000000000000000000000000000000001495 237.0
TLS2_k127_5060091_2 Belongs to the peptidase M28 family - - - 0.000000000000000000000000000000000000000000009555 180.0
TLS2_k127_5060807_0 Belongs to the peptidase S16 family - - - 7.636e-235 751.0
TLS2_k127_5060807_1 UDP-4-amino-4-deoxy-L-arabinose aminotransferase K12452,K13328 - 1.17.1.1,4.2.1.164 4.54e-203 639.0
TLS2_k127_5060807_10 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000001038 147.0
TLS2_k127_5060807_11 - - - - 0.0000000000000000000000000000008753 126.0
TLS2_k127_5060807_12 Hydrolase, nudix family K01515 - 3.6.1.13 0.00000000000000000000000000003258 124.0
TLS2_k127_5060807_13 - - - - 0.0000000000000000000000007543 115.0
TLS2_k127_5060807_14 ATPase associated with various cellular activities, AAA_5 K03696 - - 0.000000000000000000001276 97.0
TLS2_k127_5060807_15 LysM domain - - - 0.0000000000001835 78.0
TLS2_k127_5060807_16 GlcNAc-PI de-N-acetylase - - - 0.0000000000001949 75.0
TLS2_k127_5060807_17 - - - - 0.00000000001245 66.0
TLS2_k127_5060807_18 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - 0.0000004817 59.0
TLS2_k127_5060807_19 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000001015 59.0
TLS2_k127_5060807_2 Protoporphyrinogen oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000502 597.0
TLS2_k127_5060807_3 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005961 516.0
TLS2_k127_5060807_4 PFAM sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 396.0
TLS2_k127_5060807_5 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009365 360.0
TLS2_k127_5060807_6 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 316.0
TLS2_k127_5060807_7 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007522 306.0
TLS2_k127_5060807_8 O-methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000002067 230.0
TLS2_k127_5060807_9 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000000000000000001058 188.0
TLS2_k127_506772_0 Arginyl tRNA synthetase N terminal domain K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 368.0
TLS2_k127_506772_1 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007362 371.0
TLS2_k127_506772_2 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004469 261.0
TLS2_k127_506772_3 conserved repeat domain protein - - - 0.00000000000000000000000000000000000000000000002241 189.0
TLS2_k127_506772_4 amine dehydrogenase activity - - - 0.00000973 53.0
TLS2_k127_5067783_0 purine nucleotide biosynthetic process K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 410.0
TLS2_k127_5067783_1 Belongs to the PAPS reductase family. CysH subfamily K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003198 278.0
TLS2_k127_5067783_2 precorrin-2 dehydrogenase activity K02302,K02304 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000009716 246.0
TLS2_k127_5067783_3 Uroporphyrin-III C-methyltransferase K02303,K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000006602 223.0
TLS2_k127_5078612_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007954 287.0
TLS2_k127_5079439_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000004932 51.0
TLS2_k127_5083397_0 PFAM Exonuclease, RNase T and DNA polymerase III K02342,K03722 - 2.7.7.7,3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 581.0
TLS2_k127_5083397_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007492 469.0
TLS2_k127_5083397_2 PFAM cytochrome c biogenesis protein, transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000000000000631 200.0
TLS2_k127_5083397_3 Predicted membrane protein (DUF2085) - - - 0.00000000000000000000000000000000000000000698 165.0
TLS2_k127_5083397_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000008576 126.0
TLS2_k127_509003_0 Tetratricopeptide repeat protein - - - 0.00000000000000000000000000000000000003563 163.0
TLS2_k127_5103518_0 glycosyl transferase group 1 K08256 - 2.4.1.345 0.0000000000000000000000000000000000000000000000000000000586 212.0
TLS2_k127_5103518_1 Psort location Cytoplasmic, score 8.96 K03742 - 3.5.1.42 0.000000000000000000000000000001371 134.0
TLS2_k127_5103518_2 Protein of unknown function (DUF1298) - - - 0.00000000000000000000000000001729 123.0
TLS2_k127_5103518_3 PFAM cyclic nucleotide-binding - - - 0.00000000000000000001469 97.0
TLS2_k127_5103518_4 Belongs to the UPF0102 family K07460 - - 0.0000007159 52.0
TLS2_k127_511226_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1731.0
TLS2_k127_511226_1 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005603 414.0
TLS2_k127_511226_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000005344 196.0
TLS2_k127_511226_3 Peptidase M50 - - - 0.0000000000000000000000000000000000000000000000227 177.0
TLS2_k127_511226_4 sequence-specific DNA binding - - - 0.0000000000000000000000000000000000001009 150.0
TLS2_k127_511226_5 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K04517 - 1.3.1.12 0.00000000000000000000000000001614 130.0
TLS2_k127_511226_6 Psort location CytoplasmicMembrane, score - - - 0.000002359 60.0
TLS2_k127_511226_7 CHAT domain - - - 0.0002141 51.0
TLS2_k127_5115345_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 5.957e-257 806.0
TLS2_k127_5116714_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007197 449.0
TLS2_k127_5116714_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007429 383.0
TLS2_k127_5116714_10 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000001007 153.0
TLS2_k127_5116714_11 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000005845 149.0
TLS2_k127_5116714_12 TIGRFAM transposase, IS605 OrfB family, central region - - - 0.000000000000000000000000000001557 124.0
TLS2_k127_5116714_13 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000001433 120.0
TLS2_k127_5116714_14 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000002733 85.0
TLS2_k127_5116714_15 Ribosomal protein L30 K02907 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000009444 81.0
TLS2_k127_5116714_16 Ribosomal protein L36 K02919 - - 0.00000000001837 64.0
TLS2_k127_5116714_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001585 265.0
TLS2_k127_5116714_3 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000003969 225.0
TLS2_k127_5116714_4 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000000002613 203.0
TLS2_k127_5116714_5 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000001945 199.0
TLS2_k127_5116714_6 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000000002339 193.0
TLS2_k127_5116714_7 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000003303 194.0
TLS2_k127_5116714_8 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000002516 175.0
TLS2_k127_5116714_9 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000009231 166.0
TLS2_k127_5119571_0 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.000000000000000000000000000000002324 148.0
TLS2_k127_5119571_1 Glycoside hydrolase family 28 - - - 0.000000000002965 80.0
TLS2_k127_5119571_2 domain, Protein K05970 - 3.1.1.53 0.00000001441 66.0
TLS2_k127_5119571_3 SMART Integrin alpha beta-propellor repeat protein - - - 0.00000415 60.0
TLS2_k127_5121773_0 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 484.0
TLS2_k127_5121773_1 Trehalose utilisation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009517 413.0
TLS2_k127_5121773_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 298.0
TLS2_k127_5124578_0 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 419.0
TLS2_k127_5124578_1 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001416 272.0
TLS2_k127_5124836_0 Methyltransferase type 12 - - - 0.00000000000000000000000000000000000000000000000000000007343 202.0
TLS2_k127_5124836_1 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 0.0000000000000000000000000000000000000000000000000003387 190.0
TLS2_k127_5124836_3 ubiE/COQ5 methyltransferase family - - - 0.000003882 58.0
TLS2_k127_5124836_4 Belongs to the peptidase M50B family - - - 0.00003742 53.0
TLS2_k127_512534_0 PFAM O-antigen polymerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 383.0
TLS2_k127_512534_1 Protein of unknown function (DUF2723) - - - 0.0000000000000000000000000000000000000000000000000001497 203.0
TLS2_k127_512534_2 PFAM Archaeal ATPase - - - 0.00000000000000000000000000000000004689 156.0
TLS2_k127_512534_3 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000002089 80.0
TLS2_k127_512534_4 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00003087 48.0
TLS2_k127_512534_5 Peptidase family C25 - - - 0.0002219 53.0
TLS2_k127_5127299_0 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003475 291.0
TLS2_k127_5127299_1 PFAM Uncharacterised protein family (UPF0014) K02069 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0015075,GO:0016020,GO:0016021,GO:0019725,GO:0022857,GO:0030003,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098771 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009335 267.0
TLS2_k127_5127299_2 Domain of unknown function (DUF4162) K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001756 270.0
TLS2_k127_5127299_3 ABC transporter I family member - GO:0003674,GO:0005215,GO:0005338,GO:0005460,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0010035,GO:0010038,GO:0010044,GO:0012506,GO:0015075,GO:0015165,GO:0015711,GO:0015780,GO:0015786,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0031090,GO:0031982,GO:0034220,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090481,GO:0098588,GO:0098656,GO:0098805,GO:1901264,GO:1901505 - 0.0000000000000000000000000000000000000000000000000000000000002542 219.0
TLS2_k127_5127299_4 protein conserved in bacteria (DUF2087) - - - 0.000000000000000000000000000000000000000000000000000000004784 204.0
TLS2_k127_5127299_5 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000001024 138.0
TLS2_k127_5127299_6 ArsR family transcriptional regulator - - - 0.0000000000000000000002214 103.0
TLS2_k127_5127299_7 Putative membrane peptidase family (DUF2324) - - - 0.000000000000000000009829 107.0
TLS2_k127_5127299_8 Phospholipase_D-nuclease N-terminal - - - 0.0000000000000001926 80.0
TLS2_k127_5127299_9 RNA repair, ligase-Pnkp-associating, region of Hen1 - - - 0.000001792 50.0
TLS2_k127_5130777_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 3.825e-299 942.0
TLS2_k127_5130777_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000002314 265.0
TLS2_k127_5130777_2 PFAM LmbE family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001379 247.0
TLS2_k127_5130777_3 PFAM LmbE family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000003653 242.0
TLS2_k127_5130777_5 PFAM Radical SAM domain protein K22227 - - 0.0000000000004774 75.0
TLS2_k127_5134788_0 serves to protect cells from the toxic effects of hydrogen peroxide K03781 GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0042221,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070887,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1990748 1.11.1.6 1.105e-215 674.0
TLS2_k127_5134788_1 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 493.0
TLS2_k127_5145771_0 PFAM Ribonuclease BN-like family K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 348.0
TLS2_k127_5145771_1 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 314.0
TLS2_k127_5145771_2 Belongs to the peptidase S8 family K17734 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 323.0
TLS2_k127_5145771_3 PFAM ABC transporter related - - - 0.000000000000000000000000000000000000000000000000000000000000000000001578 241.0
TLS2_k127_5145771_4 Transglycosylase associated protein - - - 0.000000000000000000000000009049 111.0
TLS2_k127_5145771_5 YGGT family - - - 0.0000000000000006217 85.0
TLS2_k127_5145771_6 ADP binding - - - 0.0006604 49.0
TLS2_k127_5150835_0 PFAM Translin K07477 - - 0.000000000000000000000000000000000000000000000000000000001239 207.0
TLS2_k127_5150835_1 Glycosyl transferase, family 9 K02843,K02849 - - 0.0000000000000000000000000000000000000000000000000001932 199.0
TLS2_k127_5150835_2 TIGRFAM competence protein ComEA K02237 - - 0.000000000000000000000000000003995 128.0
TLS2_k127_5150835_3 PFAM Flavin reductase like domain - - - 0.000000000000000000000000000008209 124.0
TLS2_k127_5150835_4 Protein of unknown function (DUF3467) - - - 0.000000000000000003467 88.0
TLS2_k127_5164204_0 TIGRFAM FeS assembly protein SufB K07033,K09014 - - 1.711e-231 726.0
TLS2_k127_5164204_1 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000518 396.0
TLS2_k127_5164204_2 PFAM ABC transporter related K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 361.0
TLS2_k127_5164204_3 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 329.0
TLS2_k127_5164204_4 PFAM regulatory protein, ArsR - - - 0.0000000000000000000000000000000000000000000000000002825 192.0
TLS2_k127_5164204_5 Pfam:DUF59 - - - 0.0000000000000000001766 91.0
TLS2_k127_5165728_0 cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 506.0
TLS2_k127_5165728_1 SMART von Willebrand factor, type A K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 389.0
TLS2_k127_5165728_2 Zinc-dependent metalloprotease - - - 0.0000000000004277 82.0
TLS2_k127_5165728_3 Glycosyl hydrolase family 10 K01181 - 3.2.1.8 0.00001024 58.0
TLS2_k127_5167753_0 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 373.0
TLS2_k127_5167753_1 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. - - - 0.0000001528 55.0
TLS2_k127_5167753_2 Periplasmic component of the Tol biopolymer transport system - - - 0.0007678 48.0
TLS2_k127_5172652_0 PFAM secretion protein HlyD family protein K02004,K06218,K16552 - - 0.00000000000000000000000000000000000000000000000000000000000000002801 252.0
TLS2_k127_5215811_0 PFAM ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 385.0
TLS2_k127_5215811_1 PFAM ATPase family associated with various cellular activities (AAA) - - - 0.00000005275 54.0
TLS2_k127_5218616_0 endonuclease I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 485.0
TLS2_k127_5218616_1 Peptidase family S58 - - - 0.00000000000000000000000000000001937 132.0
TLS2_k127_5232239_0 Rieske-like [2Fe-2S] domain - - - 2.174e-242 763.0
TLS2_k127_5232239_1 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000009925 233.0
TLS2_k127_5232239_2 carbohydrate transport K02027,K10117,K11751 - 3.1.3.5,3.6.1.45 0.00000006159 60.0
TLS2_k127_5234582_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005412 572.0
TLS2_k127_5234582_1 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 483.0
TLS2_k127_5234582_2 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000005673 254.0
TLS2_k127_5234582_3 CobQ CobB MinD ParA nucleotide binding domain K08253,K16554,K16692 - 2.7.10.2 0.000000000000000000000000000000002257 132.0
TLS2_k127_5245996_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 606.0
TLS2_k127_5245996_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000004921 247.0
TLS2_k127_5245996_2 Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis K03816 - 2.4.2.22 0.00000000000000000000000000000000000000000000000000000000001 212.0
TLS2_k127_5245996_3 Belongs to the FPP GGPP synthase family K00805 - 2.5.1.30 0.0000000000000000000000000000000000000000000000000006419 197.0
TLS2_k127_5245996_4 NB-ARC domain - - - 0.0000000000000000000000007282 109.0
TLS2_k127_5245996_5 - - - - 0.000000000000009728 85.0
TLS2_k127_5245996_6 Helix-turn-helix XRE-family like proteins K18831 - - 0.000000001411 58.0
TLS2_k127_5251483_0 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 481.0
TLS2_k127_5251483_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 482.0
TLS2_k127_5251483_2 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000003339 209.0
TLS2_k127_5253419_0 PFAM Prolyl oligopeptidase family - - - 3.017e-263 826.0
TLS2_k127_5253419_1 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 0.00000000000000000000000000000000000000000000000000001556 191.0
TLS2_k127_5253419_2 NAD(P)H-binding K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000001596 178.0
TLS2_k127_5294328_0 Parallel beta-helix repeats K12287 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002004 276.0
TLS2_k127_5294328_1 Transcriptional activator domain - - - 0.0000000000000001496 91.0
TLS2_k127_5294328_2 SMART Parallel beta-helix repeat - - - 0.0000004686 64.0
TLS2_k127_5296050_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756,K01857 - 4.3.2.2,5.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 481.0
TLS2_k127_5296050_1 IMP dehydrogenase / GMP reductase domain K00088 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 0.000000000000002337 76.0
TLS2_k127_5301061_0 Molecular chaperone. Has ATPase activity K04079 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006926 422.0
TLS2_k127_5301061_1 ATPase activity K02010,K02052,K02062,K11072 - 3.6.3.30,3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 323.0
TLS2_k127_5301061_2 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 297.0
TLS2_k127_5301061_3 NTF2-like N-terminal transpeptidase domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006116 309.0
TLS2_k127_5301061_4 SMART PDZ DHR GLGF domain protein K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000009172 231.0
TLS2_k127_5301061_5 PBS lyase HEAT-like repeat - - - 0.00000000000000000000000000000000000001461 156.0
TLS2_k127_5301061_6 PFAM Auxin Efflux Carrier K07088 - - 0.00000000000000000000000000000000001574 147.0
TLS2_k127_5301061_7 Peptidase MA superfamily - - - 0.000000000000000000000002815 117.0
TLS2_k127_5305560_0 ABC transporter K09697 - 3.6.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000001013 271.0
TLS2_k127_5305560_1 ABC-type Na efflux pump, permease component K09696 - - 0.0000000000000000000000317 110.0
TLS2_k127_5305560_2 ABC-2 type transporter K01992 - - 0.0000001234 63.0
TLS2_k127_530660_0 prohibitin homologues K07192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000691 446.0
TLS2_k127_530660_1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K00760,K04075,K15780 - 2.4.2.8,6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001222 289.0
TLS2_k127_530660_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000001271 231.0
TLS2_k127_530660_3 Membrane protein implicated in regulation of membrane protease activity - - - 0.0000009629 57.0
TLS2_k127_5310601_0 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 318.0
TLS2_k127_5310601_1 Serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008241 284.0
TLS2_k127_5310601_2 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000007856 91.0
TLS2_k127_531405_0 Histidine kinase K07646,K07679 - 2.7.13.3 7.339e-215 692.0
TLS2_k127_531405_1 NB-ARC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 517.0
TLS2_k127_531405_10 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000000000000000000000000000000000000000000000002336 230.0
TLS2_k127_531405_11 integral membrane protein - - - 0.00000000000000002782 89.0
TLS2_k127_531405_12 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.00000000000001064 89.0
TLS2_k127_531405_13 PhoQ Sensor - - - 0.00000000002752 69.0
TLS2_k127_531405_14 family 18 - - - 0.000000001138 72.0
TLS2_k127_531405_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008073 482.0
TLS2_k127_531405_3 Memo-like protein K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007549 340.0
TLS2_k127_531405_4 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 310.0
TLS2_k127_531405_5 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006954 291.0
TLS2_k127_531405_6 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003632 275.0
TLS2_k127_531405_7 ATPase-coupled phosphate ion transmembrane transporter activity K02036,K06857 - 3.6.3.27,3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000005455 259.0
TLS2_k127_531405_8 sh3 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007636 259.0
TLS2_k127_531405_9 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000008903 234.0
TLS2_k127_5315947_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 508.0
TLS2_k127_5315947_1 Belongs to the PEP-utilizing enzyme family K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000003592 271.0
TLS2_k127_5315947_2 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000006855 130.0
TLS2_k127_5341244_0 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 423.0
TLS2_k127_5341244_1 fad dependent oxidoreductase K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007642 365.0
TLS2_k127_5341244_2 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 342.0
TLS2_k127_5341244_3 CBD_II K19668 - 3.2.1.91 0.00000000000000000000000000000000000000001315 153.0
TLS2_k127_5351305_0 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003153 245.0
TLS2_k127_5351305_1 Belongs to the peptidase S8 family K12287 - - 0.000000000000000000000000000000000000000000000000000000001202 231.0
TLS2_k127_5351305_2 Domain of unknown function (DUF4347) - - - 0.0000000000000000000000003145 124.0
TLS2_k127_5351305_3 6-phosphogluconolactonase activity - - - 0.000000000000000000000002852 121.0
TLS2_k127_5368808_0 PFAM transglutaminase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007429 269.0
TLS2_k127_5368808_1 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.0000000000000000000000000000000000000113 154.0
TLS2_k127_5368808_2 Large extracellular alpha-helical protein K13735 - - 0.00001431 55.0
TLS2_k127_5371066_0 Domain of unknown function (DUF4143) K07133 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006044 487.0
TLS2_k127_5371066_1 oxidoreductase activity K02012,K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 373.0
TLS2_k127_5371066_2 COG2217 Cation transport ATPase K01534 - 3.6.3.3,3.6.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000001111 253.0
TLS2_k127_5371066_3 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000001514 194.0
TLS2_k127_5371191_0 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001631 278.0
TLS2_k127_5371191_1 Belongs to the peptidase S8 family K12287 - - 0.0000000001905 75.0
TLS2_k127_5374260_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 613.0
TLS2_k127_5374260_1 PFAM ABC transporter related K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 524.0
TLS2_k127_5374260_10 Putative ATPase subunit of terminase (gpP-like) - - - 0.00000000000000000001934 95.0
TLS2_k127_5374260_11 ArsR family transcriptional regulator - - - 0.0000000001485 73.0
TLS2_k127_5374260_2 Serine threonine protein kinase K08884 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 379.0
TLS2_k127_5374260_3 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002716 277.0
TLS2_k127_5374260_4 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008783 254.0
TLS2_k127_5374260_5 enoyl-CoA hydratase isomerase family protein K13766 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000002957 240.0
TLS2_k127_5374260_6 histone H2A K63-linked ubiquitination - - - 0.0000000000000000000000000000000000000000000000000000000003367 209.0
TLS2_k127_5374260_7 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000002661 205.0
TLS2_k127_5374260_8 nuclease activity - - - 0.0000000000000000000000000000000000002151 143.0
TLS2_k127_5374260_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000003539 115.0
TLS2_k127_5381115_0 ABC transporter, transmembrane region K06147 - - 5.686e-212 674.0
TLS2_k127_5381115_1 Peptidase family M50 K06212,K06402 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003457 270.0
TLS2_k127_5381115_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000000001712 137.0
TLS2_k127_5381115_3 Lamin Tail Domain - - - 0.0000001424 58.0
TLS2_k127_5382221_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 440.0
TLS2_k127_5382221_1 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001491 262.0
TLS2_k127_5382221_2 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000008589 252.0
TLS2_k127_5382221_3 Nucleotide binding protein, PINc - - - 0.0000000000000000826 87.0
TLS2_k127_5385415_0 PFAM MscS Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 470.0
TLS2_k127_5385415_1 - - - - 0.00000000000000000006829 100.0
TLS2_k127_5385415_2 Subtilase family - - - 0.00001337 58.0
TLS2_k127_5387161_0 Family 4 glycosyl hydrolase K01222 - 3.2.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003454 548.0
TLS2_k127_5387161_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 329.0
TLS2_k127_5387161_2 helix_turn _helix lactose operon repressor K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001339 278.0
TLS2_k127_5387161_3 Protein of unknown function (DUF4013) - - - 0.000000000000002509 86.0
TLS2_k127_5389781_0 helix_turn_helix, Lux Regulon K03556 - - 4.1e-303 953.0
TLS2_k127_5389781_1 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000374 570.0
TLS2_k127_5389781_2 Chromate resistance exported protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 328.0
TLS2_k127_5389781_3 regulator of chromosome condensation, RCC1 - - - 0.00000000000000000000000000000003992 147.0
TLS2_k127_5389781_4 PKD domain - - - 0.00000000000000000000000001645 129.0
TLS2_k127_5389781_5 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104,K03325,K03741,K03892,K18701 - 1.20.4.1,2.8.4.2,3.1.3.48 0.000000000000000000000728 101.0
TLS2_k127_5389781_6 NHL repeat - - - 0.000000003366 72.0
TLS2_k127_5389781_7 Pkd domain containing protein - - - 0.0000384 58.0
TLS2_k127_5407941_0 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009744 490.0
TLS2_k127_5407941_1 peroxidase activity K00435 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000846 293.0
TLS2_k127_5407941_2 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 289.0
TLS2_k127_5407941_3 Porphobilinogen deaminase, dipyromethane cofactor binding domain K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 292.0
TLS2_k127_5407941_4 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006783 282.0
TLS2_k127_5407941_5 TIGRFAM DNA binding domain - - - 0.00000000000000000000000000000000000000000001206 170.0
TLS2_k127_5407941_6 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.0000000000000000000000000000000000000000001859 169.0
TLS2_k127_5407941_7 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000004218 133.0
TLS2_k127_5407941_8 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.0000000000000000000004112 98.0
TLS2_k127_5407941_9 FeoC like transcriptional regulator - - - 0.0000003937 58.0
TLS2_k127_5410288_0 PFAM glycoside hydrolase, family 3 domain protein K05349 - 3.2.1.21 6.999e-227 720.0
TLS2_k127_5410288_1 alpha-L-arabinofuranosidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 376.0
TLS2_k127_5410288_2 carbohydrate binding K00702 - 2.4.1.20 0.000000000000000000113 91.0
TLS2_k127_5411774_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000008433 132.0
TLS2_k127_5411774_1 PFAM response regulator receiver K11443 - - 0.0000000000000000000000000268 113.0
TLS2_k127_541283_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 6.821e-198 623.0
TLS2_k127_541283_1 PFAM PfkB domain protein K00856 - 2.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 399.0
TLS2_k127_541283_2 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000292 181.0
TLS2_k127_541283_3 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000597 145.0
TLS2_k127_541283_4 LysM domain - - - 0.00000000000000000000001558 113.0
TLS2_k127_541283_5 Bacterial transcriptional activator domain - - - 0.000006265 54.0
TLS2_k127_5428644_0 PFAM carbohydrate kinase K00854 - 2.7.1.17 3.425e-220 692.0
TLS2_k127_5428644_1 PFAM Xylose isomerase domain protein TIM barrel K01805 - 5.3.1.5 0.00000000000000000000000000000000000001993 145.0
TLS2_k127_5428644_2 PFAM YcfA-like protein - - - 0.000000000000000000000000002333 112.0
TLS2_k127_5428644_3 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000009413 91.0
TLS2_k127_5443446_0 PFAM glycosyl transferase, family 51 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009163 381.0
TLS2_k127_5443446_1 cellulase activity K01183 - 3.2.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000001057 276.0
TLS2_k127_5447011_0 Fructose-bisphosphate aldolase class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 517.0
TLS2_k127_5447011_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004373 402.0
TLS2_k127_5447011_2 phosphate transport system permease protein K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 417.0
TLS2_k127_5447011_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009857 367.0
TLS2_k127_5447011_4 probably responsible for the translocation of the substrate across the membrane K02037,K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001129 243.0
TLS2_k127_5447011_5 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000002031 187.0
TLS2_k127_5447011_6 PFAM Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000001465 53.0
TLS2_k127_5452833_0 MFS/sugar transport protein K03292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003448 407.0
TLS2_k127_5452833_1 YCII-related domain - - - 0.000000000000000000000000000000000000002665 151.0
TLS2_k127_5452833_2 Protein of unknown function (DUF433) - - - 0.00000000000000000000000000000000000001564 146.0
TLS2_k127_5452833_3 WD domain, G-beta repeat - - - 0.00000000000001356 75.0
TLS2_k127_5460872_0 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 537.0
TLS2_k127_5460872_1 CO dehydrogenase flavoprotein C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 387.0
TLS2_k127_5460872_2 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 303.0
TLS2_k127_5475653_0 Integral membrane protein TerC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002286 246.0
TLS2_k127_5475653_1 SMART Tetratricopeptide domain protein - - - 0.000000000000004106 87.0
TLS2_k127_5476824_0 PFAM ATP-binding region, ATPase domain protein K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 381.0
TLS2_k127_5476824_1 TIGRFAM phosphate ABC transporter, inner membrane subunit PstA K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 359.0
TLS2_k127_5476824_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 347.0
TLS2_k127_5476824_3 TIGRFAM phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 331.0
TLS2_k127_5476824_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000032 303.0
TLS2_k127_5476824_5 TIGRFAM phosphate binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001471 280.0
TLS2_k127_5476824_6 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000001044 239.0
TLS2_k127_5476824_7 Two component transcriptional regulator, winged helix family K02483 - - 0.00000000000000000000001439 100.0
TLS2_k127_5481526_0 Late control gene D protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 472.0
TLS2_k127_5481526_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 295.0
TLS2_k127_5481526_2 Rhs element vgr protein - - - 0.00000000000000000000000000000000000000000000000000000000001897 211.0
TLS2_k127_5481526_3 PFAM Gene 25-like lysozyme K06903 - - 0.0000000000000000000000000000000000000000000007344 174.0
TLS2_k127_5481526_4 positive regulation of growth rate - GO:0003674,GO:0005488,GO:0008150,GO:0010035,GO:0010038,GO:0030955,GO:0031420,GO:0035864,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896 - 0.00000000000000000000000000000000000000003729 155.0
TLS2_k127_5481526_5 - - - - 0.0000000000000000000000000000000000001568 143.0
TLS2_k127_5498081_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 503.0
TLS2_k127_5498081_1 response regulator, receiver K09763 - - 0.00000000000000000000000000000000000000007351 162.0
TLS2_k127_5498081_2 Cytochrome oxidase assembly protein K02259 - - 0.0000000000000000000223 98.0
TLS2_k127_5498081_3 ubiE/COQ5 methyltransferase family - - - 0.00000000003953 72.0
TLS2_k127_5513830_0 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004288 500.0
TLS2_k127_5513830_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III domain protein K01641 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 492.0
TLS2_k127_5513830_2 Glycosyltransferase like family 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004997 249.0
TLS2_k127_5513830_3 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000001773 235.0
TLS2_k127_5513830_4 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000002305 155.0
TLS2_k127_5513830_5 Phosphonate ABC transporter K02044 - - 0.00000000005285 74.0
TLS2_k127_552876_0 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000458 500.0
TLS2_k127_552876_1 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 367.0
TLS2_k127_552876_2 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001252 292.0
TLS2_k127_552876_3 PFAM Acetyltransferase (GNAT) family K00657 - 2.3.1.57 0.000000000000000000000000000000000000000000000263 177.0
TLS2_k127_552876_4 bacterial-type flagellum-dependent cell motility - - - 0.000000000000000000000000000000001158 145.0
TLS2_k127_552876_5 Fibronectin type III domain - - - 0.00000000000000000000000007453 123.0
TLS2_k127_552876_6 Stress responsive A/B Barrel Domain - - - 0.0000000000000000000000007341 114.0
TLS2_k127_552876_7 Cupin domain-containing protein - - - 0.0003691 48.0
TLS2_k127_5562026_0 Aldehyde dehydrogenase family K20928 - 1.2.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 604.0
TLS2_k127_5562026_1 PFAM acyl-CoA dehydrogenase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 442.0
TLS2_k127_558726_0 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 419.0
TLS2_k127_558726_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002072 251.0
TLS2_k127_558726_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000046 240.0
TLS2_k127_558726_3 beta-lactamase K17836 - 3.5.2.6 0.00000000000000000000000000000000000000000000005254 180.0
TLS2_k127_558726_5 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000002973 57.0
TLS2_k127_5590778_0 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000682 301.0
TLS2_k127_5590778_1 cell envelope-related transcriptional attenuator - - - 0.000000000000000000000000000000000000003934 164.0
TLS2_k127_5591534_0 Penicillin amidase K07116 - 3.5.1.97 1.124e-212 682.0
TLS2_k127_5591534_1 recombinase activity K07450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000001047 195.0
TLS2_k127_5595944_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000541 580.0
TLS2_k127_5595944_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 413.0
TLS2_k127_5595944_2 Protein of unknown function (DUF664) - - - 0.0000000000000000000000000000000000000000000000000000000000004285 216.0
TLS2_k127_5595944_3 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000001272 206.0
TLS2_k127_5595944_4 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000000000000000000000000000000001895 200.0
TLS2_k127_5595944_5 DinB family - - - 0.0000000000000000000000000000000000000000000000000000001357 201.0
TLS2_k127_5595944_6 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000000000000002776 156.0
TLS2_k127_5609739_0 Protein of unknown function (DUF3179) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 351.0
TLS2_k127_5609739_1 oligoendopeptidase F - - - 0.00000000000000000000000000000000000000000000000000000000000000000001227 251.0
TLS2_k127_5609739_2 Major facilitator Superfamily K08218 - - 0.0000000000000000000000000000000000000000000000000005904 201.0
TLS2_k127_5609739_3 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000002564 83.0
TLS2_k127_5614076_0 Tryptophan halogenase K14257 - 1.14.19.49 1.93e-201 644.0
TLS2_k127_5614076_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 331.0
TLS2_k127_5614076_2 Binding-protein-dependent transport system inner membrane component K02054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008271 274.0
TLS2_k127_5614076_3 Binding-protein-dependent transport system inner membrane component K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000121 272.0
TLS2_k127_5614076_4 Belongs to the glutamate synthase family - - - 0.0000000000000000000000000000000000000000000000000000007956 195.0
TLS2_k127_5614076_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.000000000000000000000000000000000000000000000000001415 189.0
TLS2_k127_5615272_0 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 337.0
TLS2_k127_5615272_1 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000003266 194.0
TLS2_k127_5615272_2 DNA helicase - - - 0.00000000000000000003114 104.0
TLS2_k127_5615272_3 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03404,K03405 - 6.6.1.1 0.000000000000000001491 88.0
TLS2_k127_5629245_0 Protein of unknown function, DUF255 K06888 - - 2.962e-230 734.0
TLS2_k127_5629245_1 PFAM Sulfate transporter antisigma-factor antagonist STAS K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 579.0
TLS2_k127_5629245_2 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000005496 266.0
TLS2_k127_5629245_3 Protein of unknown function (DUF2785) - - - 0.000000000000000000000000000000000000000000000000000000000000000001865 236.0
TLS2_k127_5629245_4 Protein of unknown function, DUF488 - - - 0.00000000000000000000002447 106.0
TLS2_k127_5629245_5 Tetratricopeptide TPR_2 repeat protein - - - 0.000000005228 69.0
TLS2_k127_5629245_6 Glycosyl hydrolase family 9 K01179 - 3.2.1.4 0.00000007335 54.0
TLS2_k127_5629245_7 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000004882 55.0
TLS2_k127_5636063_0 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K09181 - - 0.0 1200.0
TLS2_k127_5636063_1 cytochrome p450 K15468 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 364.0
TLS2_k127_5636063_2 branched-chain-amino-acid transaminase activity K02619 - 4.1.3.38 0.000000000000000000000000000000000000000000000000007958 191.0
TLS2_k127_5636063_3 Belongs to the OMP decarboxylase family. Type 2 subfamily K00762,K01591,K13421 GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10,4.1.1.23 0.000000000000000000000000000000000000000000000000741 181.0
TLS2_k127_5636063_4 Tellurite resistance protein TehB - - - 0.000000000000000000000000000000000000001667 158.0
TLS2_k127_5636063_5 Globin - - - 0.00000000000000000000000000004357 121.0
TLS2_k127_5636063_6 SMART tyrosine protein kinase - - - 0.0000000000000131 78.0
TLS2_k127_565810_0 ATP-binding region, ATPase domain protein K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 486.0
TLS2_k127_565810_1 PFAM histidine kinase, HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 303.0
TLS2_k127_565810_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000004719 213.0
TLS2_k127_565810_3 PFAM CheW domain protein K03408 - - 0.00000000000000002748 88.0
TLS2_k127_565810_4 chemotaxis protein methyltransferase K00575 - 2.1.1.80 0.0000002782 59.0
TLS2_k127_5663302_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 3.441e-300 936.0
TLS2_k127_5663302_1 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 315.0
TLS2_k127_5663302_2 Inositol monophosphatase family K01092,K05602 - 3.1.3.15,3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006863 291.0
TLS2_k127_5663302_3 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000001384 220.0
TLS2_k127_5665308_0 PFAM Citrate transporter - - - 1.823e-232 743.0
TLS2_k127_566836_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.9e-246 776.0
TLS2_k127_566836_1 COG0286 Type I restriction-modification system methyltransferase subunit K03427 - 2.1.1.72 0.00000000000005738 73.0
TLS2_k127_566836_2 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.00000003823 66.0
TLS2_k127_566836_3 transcriptional regulator - - - 0.00005243 51.0
TLS2_k127_5684690_0 PFAM ABC-3 protein K11709 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 443.0
TLS2_k127_5684690_1 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000002641 108.0
TLS2_k127_5684690_2 ABC 3 transport family K11708 - - 0.0000000000000000000004997 100.0
TLS2_k127_5684690_3 phosphoenolpyruvate synthase K01007 - 2.7.9.2 0.00000003681 56.0
TLS2_k127_5688064_0 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 288.0
TLS2_k127_5688064_1 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000000000000008488 224.0
TLS2_k127_5688064_2 Transcriptional regulator, Crp Fnr family K01420,K10914 - - 0.000000000000000000000000000000000000000000004911 172.0
TLS2_k127_5688064_3 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000005213 87.0
TLS2_k127_5688064_4 Protein of unknown function (DUF3307) - - - 0.000002726 56.0
TLS2_k127_5711212_0 ABC transporter, transmembrane region K06147,K18890 - - 7.672e-226 715.0
TLS2_k127_5711212_1 PFAM ABC transporter transmembrane region K06147 - - 1.991e-216 685.0
TLS2_k127_5711212_2 DNA-binding protein - - - 0.00000000000000000000005398 102.0
TLS2_k127_5711212_3 PFAM PKD domain containing protein - - - 0.0000000000000000003386 104.0
TLS2_k127_5711212_4 Parallel beta-helix repeats - - - 0.00002564 58.0
TLS2_k127_5717417_0 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 421.0
TLS2_k127_5717417_1 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 381.0
TLS2_k127_5717417_2 PFAM pyridoxamine 5'-phosphate K07005 - - 0.00000000004635 68.0
TLS2_k127_5717417_3 HNH endonuclease - - - 0.00000005025 55.0
TLS2_k127_572590_0 PFAM Conserved region in glutamate synthase K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.7.1 0.0 1903.0
TLS2_k127_572590_1 TIGRFAM glutamate synthases, NADH NADPH, small subunit K00266 - 1.4.1.13,1.4.1.14 1.093e-214 678.0
TLS2_k127_572590_2 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003133 287.0
TLS2_k127_572590_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000002067 208.0
TLS2_k127_572590_4 PFAM Maf family protein K06287 - - 0.0000000000000000000000000000000000000000584 160.0
TLS2_k127_572590_5 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000000000009195 154.0
TLS2_k127_572590_6 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000007076 113.0
TLS2_k127_5731634_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 0.0 1249.0
TLS2_k127_5731634_1 Histidine kinase - - - 0.000000000000000000000000002618 116.0
TLS2_k127_5731634_2 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.00000005289 55.0
TLS2_k127_5731634_3 PFAM peptidase M3A and M3B, thimet oligopeptidase F - - - 0.0000001731 55.0
TLS2_k127_5736503_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 4.036e-299 931.0
TLS2_k127_5736503_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 3.492e-203 638.0
TLS2_k127_5736503_2 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001508 248.0
TLS2_k127_5736503_3 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000000000000002394 219.0
TLS2_k127_5736503_4 Forms part of the polypeptide exit tunnel K02926 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000005643 215.0
TLS2_k127_5736503_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000000000000000000297 197.0
TLS2_k127_5736503_6 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000002579 186.0
TLS2_k127_5736503_7 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000000004315 101.0
TLS2_k127_573728_0 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 608.0
TLS2_k127_573728_1 D-galactarate dehydratase Altronate K01685,K01708 - 4.2.1.42,4.2.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000001893 267.0
TLS2_k127_573728_2 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000000000000000000000002178 235.0
TLS2_k127_5741765_0 NAD(P)H-binding K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 441.0
TLS2_k127_5741765_1 Tryptophan halogenase K16033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 427.0
TLS2_k127_5741765_2 PFAM Glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001002 261.0
TLS2_k127_5741765_3 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.00000000000000000000000000000000000000000000000000000000003817 219.0
TLS2_k127_5741765_4 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.00000000000000000000000000000000000000000000000000000006446 209.0
TLS2_k127_5741765_5 Belongs to the ATP-dependent AMP-binding enzyme family - - - 0.000000000000000000000000000002587 123.0
TLS2_k127_5741765_6 Acyl carrier protein - - - 0.000001115 56.0
TLS2_k127_5762060_0 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002811 299.0
TLS2_k127_5762060_1 PFAM NUDIX hydrolase - - - 0.000000000000000000000000000000000000000000000001021 178.0
TLS2_k127_5762060_2 Bacterial membrane protein YfhO - - - 0.0000000000000000001743 98.0
TLS2_k127_5762060_3 COG NOG23385 non supervised orthologous group - - - 0.00000006332 62.0
TLS2_k127_5763651_0 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 - 2.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 589.0
TLS2_k127_5763651_1 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 - 4.1.3.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 474.0
TLS2_k127_5763651_2 TIGRFAM isochorismate synthase K02361,K02552 - 5.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 465.0
TLS2_k127_5763651_3 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily K01911 - 6.2.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 428.0
TLS2_k127_5763651_4 PFAM regulatory protein TetR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007014 263.0
TLS2_k127_5763651_5 phosphatidylcholine synthase K01004 - 2.7.8.24 0.0000000000000000000000000000000000000000000000000001286 194.0
TLS2_k127_5763651_6 Transglycosylase associated protein - - - 0.0000000000000000000001381 99.0
TLS2_k127_5768643_0 ThiF family K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007165 370.0
TLS2_k127_5768643_1 Two component transcriptional regulator, winged helix family K07658 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001702 267.0
TLS2_k127_5768643_2 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000001508 265.0
TLS2_k127_5768643_3 histidine kinase A domain protein K02484 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000004913 259.0
TLS2_k127_5768643_4 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000005408 244.0
TLS2_k127_5768643_5 WXG100 protein secretion system (Wss), protein YukD - - - 0.000000000000002735 78.0
TLS2_k127_5768643_6 PFAM Ubiquitin-conjugating - - - 0.000000000000004493 79.0
TLS2_k127_5768643_7 Phosphopantetheine attachment site - - - 0.00002496 49.0
TLS2_k127_5776741_0 Belongs to the glycosyl hydrolase 31 family K01811 GO:0003674,GO:0003824,GO:0004553,GO:0005488,GO:0005515,GO:0016787,GO:0016798,GO:0042802,GO:0080176 3.2.1.177 0.0 1098.0
TLS2_k127_5776741_1 PFAM peptidase M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000484 411.0
TLS2_k127_5776741_2 Belongs to the BI1 family K06890 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000001967 179.0
TLS2_k127_5776741_3 Protein of unknown function (DUF3048) C-terminal domain - - - 0.0000000000000000000000000000000000000001736 165.0
TLS2_k127_5776741_4 Protein of unknown function (DUF421) - - - 0.000000000000001359 78.0
TLS2_k127_5790603_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 320.0
TLS2_k127_5790603_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000006612 71.0
TLS2_k127_5790603_2 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000122 66.0
TLS2_k127_5790603_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000005215 51.0
TLS2_k127_5794422_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298,K15408 - 1.10.3.10,1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 560.0
TLS2_k127_5794422_1 Cytochrome c - - - 0.00000000000000000000000000000000004595 139.0
TLS2_k127_5794422_2 - - - - 0.00002021 52.0
TLS2_k127_5794422_3 Gluconate 2-dehydrogenase subunit 3 K06152 - 1.1.99.3 0.00005057 53.0
TLS2_k127_5810377_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004642 519.0
TLS2_k127_5810377_1 - - - - 0.0000000000000000000000000000000538 126.0
TLS2_k127_5813232_0 PFAM alpha amylase, catalytic K01208 - 3.2.1.133,3.2.1.135,3.2.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 572.0
TLS2_k127_5813232_1 Lipocalin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 429.0
TLS2_k127_5813232_2 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 331.0
TLS2_k127_5813232_3 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000005949 256.0
TLS2_k127_5813232_4 phosphorelay sensor kinase activity K01768,K02482,K02584,K07673,K10819 - 2.7.13.3,4.6.1.1 0.000000000000000000000000000000000000000000000000000000002121 225.0
TLS2_k127_5813232_5 S-adenosyl methyltransferase - - - 0.000000000000000000000000000000000000000000000000000002327 200.0
TLS2_k127_5813232_6 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000003974 176.0
TLS2_k127_5813232_7 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000005591 129.0
TLS2_k127_5813232_8 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000002332 110.0
TLS2_k127_5813232_9 cellulose binding - - - 0.00000006699 59.0
TLS2_k127_581790_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 3.899e-291 905.0
TLS2_k127_581790_1 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 479.0
TLS2_k127_581790_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 448.0
TLS2_k127_581790_3 PFAM ABC transporter related K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 399.0
TLS2_k127_581790_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 400.0
TLS2_k127_581790_5 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 356.0
TLS2_k127_581790_6 Periplasmic binding protein domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003804 353.0
TLS2_k127_5821090_0 Belongs to the SEDS family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 446.0
TLS2_k127_5821090_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 332.0
TLS2_k127_5821090_2 PFAM MCP methyltransferase CheR-type K00575 - 2.1.1.80 0.00000000000000000000000000000000000000001928 162.0
TLS2_k127_5821090_3 chemotaxis signal transduction protein K03408 - - 0.000000000000000004994 91.0
TLS2_k127_584854_0 Serine carboxypeptidase - - - 1.526e-208 659.0
TLS2_k127_584854_1 Short-chain dehydrogenase reductase sdr - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002803 279.0
TLS2_k127_584854_2 Peptidase_C39 like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000241 252.0
TLS2_k127_584854_3 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000135 220.0
TLS2_k127_5849767_0 histidine kinase, dimerisation and phosphoacceptor region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 449.0
TLS2_k127_5849767_1 Two component transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000000000000000000004257 219.0
TLS2_k127_5866793_0 ABC transporter transmembrane region K06147 - - 1.189e-226 717.0
TLS2_k127_5866793_1 ABC transporter transmembrane region K06147 - - 2.625e-216 686.0
TLS2_k127_5866793_2 COG2706 3-carboxymuconate cyclase K07404 - 3.1.1.31 0.000000000000000001413 90.0
TLS2_k127_5870011_0 protein histidine kinase activity K01768,K02484,K07636,K10681,K10819,K18350,K20487 - 2.7.13.3,4.6.1.1 0.000000000000000000000000000000000000000000000001828 190.0
TLS2_k127_5870011_1 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000004953 190.0
TLS2_k127_5870011_2 Protein tyrosine kinase - - - 0.00000000000000000004215 104.0
TLS2_k127_5879014_0 ABC-type multidrug transport system ATPase and permease K06147 - - 7.72e-249 781.0
TLS2_k127_5879014_1 Type III restriction enzyme res subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004878 486.0
TLS2_k127_5879014_2 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000006269 187.0
TLS2_k127_5879014_3 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine - - - 0.0000000000000000000000000000000000002302 150.0
TLS2_k127_5879014_4 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000004233 151.0
TLS2_k127_5879014_5 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000000000000000000000000009808 134.0
TLS2_k127_5879014_6 COGs COG3372 conserved K09744 - - 0.0000000005531 64.0
TLS2_k127_58794_0 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003642 276.0
TLS2_k127_58794_1 PFAM glutamine amidotransferase class-I K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000527 230.0
TLS2_k127_58794_2 helix_turn_helix ASNC type K03718 - - 0.00000000000000000000000000000001177 132.0
TLS2_k127_58794_3 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000004215 126.0
TLS2_k127_58794_4 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.000000000000000000000001095 115.0
TLS2_k127_58794_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.0000000003452 63.0
TLS2_k127_5889104_0 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009526 382.0
TLS2_k127_5889104_1 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 369.0
TLS2_k127_5889104_2 Glucose sorbosone - - - 0.000003214 49.0
TLS2_k127_589510_0 PFAM Methionine synthase vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 557.0
TLS2_k127_589510_1 ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004478 261.0
TLS2_k127_589510_2 (ABC) transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000001603 231.0
TLS2_k127_589510_3 Protocatechuate 3,4-dioxygenase beta subunit N terminal K00449 - 1.13.11.3 0.00000000000000000000000000000000000000000000000000000000000005476 214.0
TLS2_k127_589510_4 - - - - 0.0000000000000000000000000000000000000000000000000000277 197.0
TLS2_k127_589510_5 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000005105 194.0
TLS2_k127_589510_6 Dioxygenase K00448 - 1.13.11.3 0.0000000000000000000000000000000000000000000000002523 181.0
TLS2_k127_589510_7 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000002556 179.0
TLS2_k127_589510_8 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000001671 168.0
TLS2_k127_5904375_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.00000000000000000000000000000000000000000000000000000000000000000005436 250.0
TLS2_k127_5908994_0 Aminotransferase class-III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009754 381.0
TLS2_k127_5908994_1 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.000000000000000000000000000000000000000000000003774 179.0
TLS2_k127_5915961_0 Belongs to the malate synthase family K01638 - 2.3.3.9 8.431e-242 756.0
TLS2_k127_5915961_1 isocitrate K01637 - 4.1.3.1 4.143e-200 632.0
TLS2_k127_5915961_2 sequence-specific DNA binding K07110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 405.0
TLS2_k127_5915961_3 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07658 - - 0.000000000000000000000000000000000000000000000000000000000000000002939 233.0
TLS2_k127_59354_0 PFAM peptidase M16 domain protein K06972 - - 1.985e-281 886.0
TLS2_k127_59354_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005356 384.0
TLS2_k127_59354_2 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006926 351.0
TLS2_k127_59354_3 Belongs to the TrpC family K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000001301 256.0
TLS2_k127_59354_4 4-vinyl reductase, 4VR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000167 246.0
TLS2_k127_59354_5 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000003168 154.0
TLS2_k127_5939288_0 PFAM tail sheath protein K06907 - - 5.165e-225 707.0
TLS2_k127_5939288_1 Protein of unknown function (DUF4255) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009966 346.0
TLS2_k127_5939288_2 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 319.0
TLS2_k127_5939288_3 PFAM T4 bacteriophage base plate protein - - - 0.000000000000000000000000000000000000000000000000000000000000000001032 236.0
TLS2_k127_5939288_4 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000000007808 200.0
TLS2_k127_5939288_6 - - - - 0.0001056 49.0
TLS2_k127_5942457_0 Belongs to the pseudouridine synthase RsuA family K06178,K06182,K06183 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.21,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000001368 229.0
TLS2_k127_5942457_1 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000003923 228.0
TLS2_k127_5942457_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000001526 194.0
TLS2_k127_5942457_3 domain, Protein - - - 0.0000000000000001033 83.0
TLS2_k127_5942457_4 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.0003683 45.0
TLS2_k127_5949794_0 UTP--glucose-1-phosphate uridylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 459.0
TLS2_k127_5949794_1 transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006247 477.0
TLS2_k127_5949794_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000003572 90.0
TLS2_k127_5949794_3 Tetratricopeptide repeat - - - 0.000611 46.0
TLS2_k127_5969577_0 Myo-inositol-1-phosphate synthase, GAPDH domain protein K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007301 598.0
TLS2_k127_5969577_1 acetyltransferase - - - 0.0000000000000000000000000000000000000005507 153.0
TLS2_k127_5969577_2 Bacterial membrane protein YfhO - - - 0.0000000000000000000000000001035 123.0
TLS2_k127_5970062_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1654.0
TLS2_k127_5970062_1 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 429.0
TLS2_k127_5970062_2 - - - - 0.00000000000000000000000000000000000006075 145.0
TLS2_k127_5970062_4 Protein of unknown function (DUF433) - - - 0.00000000000000000000000000004788 118.0
TLS2_k127_5970062_5 Involved in the TonB-independent uptake of proteins K03641 - - 0.000000000000000000000001089 119.0
TLS2_k127_5975785_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 371.0
TLS2_k127_5975785_1 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000009276 224.0
TLS2_k127_5975785_2 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000001182 93.0
TLS2_k127_5975785_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177,K03483 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000006415 79.0
TLS2_k127_6006359_0 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003346 328.0
TLS2_k127_6006359_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007479 279.0
TLS2_k127_6006359_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000007015 217.0
TLS2_k127_6006359_3 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000001173 130.0
TLS2_k127_6031727_0 TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate family K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 513.0
TLS2_k127_6031727_1 PFAM response regulator receiver K02282 - - 0.000000000000000000003411 102.0
TLS2_k127_603376_0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 1.084e-269 847.0
TLS2_k127_603376_1 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004377 504.0
TLS2_k127_603376_2 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.0000000000000000000000000000000000000000000000000004471 190.0
TLS2_k127_603376_3 Transcriptional - - - 0.0000000000000000000000001643 109.0
TLS2_k127_6050333_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000574 533.0
TLS2_k127_6050333_1 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 384.0
TLS2_k127_6050333_10 Histidine kinase - - - 0.0000001953 63.0
TLS2_k127_6050333_2 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 307.0
TLS2_k127_6050333_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000007544 237.0
TLS2_k127_6050333_4 Deoxynucleoside kinase K15518 - 2.7.1.113 0.000000000000000000000000000000000000000000000000000000000001307 223.0
TLS2_k127_6050333_5 molybdenum cofactor guanylyltransferase activity K03752,K13818 GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.77 0.00000000000000000000000000000000000000000000005125 179.0
TLS2_k127_6050333_6 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000001121 153.0
TLS2_k127_6050333_7 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000002688 115.0
TLS2_k127_6050333_8 Mazg nucleotide pyrophosphohydrolase K02428 - 3.6.1.66 0.000000000000000001064 98.0
TLS2_k127_6050333_9 Recombinase zinc beta ribbon domain - - - 0.00000001028 58.0
TLS2_k127_6071670_0 SMART Elongator protein 3 MiaB NifB - - - 1.091e-272 848.0
TLS2_k127_6071670_1 Carbamoyltransferase C-terminus K00612 - - 3.917e-247 776.0
TLS2_k127_6071670_10 - - - - 0.000000000000004827 82.0
TLS2_k127_6071670_11 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.0000000000005601 75.0
TLS2_k127_6071670_12 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000002003 55.0
TLS2_k127_6071670_2 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 437.0
TLS2_k127_6071670_3 PFAM transferase hexapeptide repeat containing protein K00661 - 2.3.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006274 348.0
TLS2_k127_6071670_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006317 247.0
TLS2_k127_6071670_5 negative regulation of translational initiation - - - 0.000000000000000000000000000000000000000002216 160.0
TLS2_k127_6071670_6 HEPN domain - - - 0.000000000000000000000000000000000000000006952 158.0
TLS2_k127_6071670_7 Peptidase, M23 - - - 0.00000000000000000000000000000000006805 153.0
TLS2_k127_6071670_8 nucleotidyltransferase activity K07076 - - 0.00000000000000000000000000005097 119.0
TLS2_k127_6071670_9 O-antigen ligase like membrane protein - - - 0.000000000000000000001732 109.0
TLS2_k127_6071965_0 response regulator K03413,K07719 - - 0.000000000008022 70.0
TLS2_k127_6071965_1 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000123 68.0
TLS2_k127_6075280_0 thiamine transport K02063 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015234,GO:0015238,GO:0015893,GO:0016020,GO:0022857,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071934,GO:0071944,GO:0072348,GO:0072531,GO:0090482,GO:1901474,GO:1901682 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 536.0
TLS2_k127_6075280_1 AcrB/AcrD/AcrF family K03296 - - 0.0000000000000000000000000000000000000000003824 170.0
TLS2_k127_6075280_2 - - - - 0.00000000000000000000001995 109.0
TLS2_k127_6075280_3 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000000000000000003652 93.0
TLS2_k127_6075280_4 PFAM Stage V sporulation protein S K06416 - - 0.00000000000000001967 91.0
TLS2_k127_608489_0 Bacterial extracellular solute-binding protein K02064 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 424.0
TLS2_k127_608489_1 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 405.0
TLS2_k127_608489_2 signal peptide peptidase SppA, 36K type K04773,K04774 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 364.0
TLS2_k127_608489_3 Thiamin pyrophosphokinase, vitamin B1 binding domain K00949 - 2.7.6.2 0.000000000000000000000000000000000000000002576 165.0
TLS2_k127_608489_4 COG NOG14600 non supervised orthologous group - - - 0.00000000000000000000000006154 107.0
TLS2_k127_608489_5 - - - - 0.0001409 46.0
TLS2_k127_608489_6 - - - - 0.0002999 44.0
TLS2_k127_6092701_0 elongation factor Tu domain 2 protein K06207 - - 7.362e-270 846.0
TLS2_k127_6092701_1 COGs COG1132 ABC-type multidrug transport system ATPase and permease components K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008761 530.0
TLS2_k127_6092701_2 PFAM NADP oxidoreductase coenzyme F420-dependent K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 428.0
TLS2_k127_6092701_3 glycosyl transferase group 1 K08256,K12995 - 2.4.1.345,2.4.1.348 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008323 327.0
TLS2_k127_6092701_4 ABC transporter transmembrane region K06147,K06148 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 296.0
TLS2_k127_6092701_5 Protein of unknown function (DUF1706) - - - 0.0000000000000001197 87.0
TLS2_k127_609862_0 quinone binding K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 415.0
TLS2_k127_609862_1 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 357.0
TLS2_k127_609862_2 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007008 308.0
TLS2_k127_609862_3 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K14090 - - 0.000000000000000000000000000000000000000000000000000001033 194.0
TLS2_k127_609862_4 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000002051 198.0
TLS2_k127_609862_5 4Fe-4S binding domain K14091 - - 0.00000000000000000000000000000000000000000000002524 173.0
TLS2_k127_609862_7 hydrogenase maturation protease K08315 - 3.4.23.51 0.0000000000000000000001239 103.0
TLS2_k127_6113827_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 373.0
TLS2_k127_6113827_1 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000228 52.0
TLS2_k127_6120910_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005979 422.0
TLS2_k127_6120910_1 ABC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 402.0
TLS2_k127_6120910_2 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 302.0
TLS2_k127_6120910_3 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000004546 109.0
TLS2_k127_6120910_4 Cysteine-rich secretory protein family - - - 0.000000000000001216 91.0
TLS2_k127_6137764_0 Bacterial lipoate protein ligase C-terminus K03800 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0017118,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:0140096,GO:1901564 6.3.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 386.0
TLS2_k127_6137764_1 Peptidase M16 domain protein K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003433 391.0
TLS2_k127_6137764_2 sodium-dependent phosphate transmembrane transporter activity K03324,K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 326.0
TLS2_k127_6137764_3 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000004727 209.0
TLS2_k127_6137764_4 heme binding - - - 0.0000000000000000000000000006793 127.0
TLS2_k127_6137764_5 Calcineurin-like phosphoesterase K07098 - - 0.00000000000001214 74.0
TLS2_k127_6137764_6 Universal stress protein - - - 0.00000000002191 74.0
TLS2_k127_6139024_0 histidine kinase, dimerisation and phosphoacceptor region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 458.0
TLS2_k127_6139024_1 Glycosyltransferase family 28 N-terminal domain K05841 - 2.4.1.173 0.00000000000000000000000000000000000000000000000000000000000000000007656 238.0
TLS2_k127_6139024_2 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000004131 74.0
TLS2_k127_6139024_3 AAA domain - - - 0.00000000003382 71.0
TLS2_k127_6139024_4 helix_turn_helix, Lux Regulon - - - 0.0000000114 57.0
TLS2_k127_6140235_0 DNA alkylation repair - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000993 338.0
TLS2_k127_6140235_1 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008094 311.0
TLS2_k127_6140235_2 MgtC family K07507 - - 0.000000000000000000000000000000000000007812 149.0
TLS2_k127_6140235_3 SPTR D1C1B9 DinB family protein - - - 0.000000000000000000000000000000001553 135.0
TLS2_k127_6140235_4 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K04517 - 1.3.1.12 0.00000000000000000000000000000000159 137.0
TLS2_k127_6140235_5 PFAM acylphosphatase K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.0000000000000000000000006103 106.0
TLS2_k127_6140235_6 PFAM NAD-dependent epimerase dehydratase K01709,K01784 - 4.2.1.45,5.1.3.2 0.000000000000000000003939 104.0
TLS2_k127_6140235_7 - - - - 0.0000000001683 74.0
TLS2_k127_6140235_8 - - - - 0.0000005826 61.0
TLS2_k127_6141937_0 Binding-protein-dependent transport systems inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 485.0
TLS2_k127_6141937_1 PFAM Amidohydrolase 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 469.0
TLS2_k127_6141937_10 - - - - 0.0000000002044 66.0
TLS2_k127_6141937_11 PFAM FeoA family protein K04758 - - 0.00000005855 57.0
TLS2_k127_6141937_12 Tellurite resistance protein TehB - - - 0.0000001494 57.0
TLS2_k127_6141937_13 Tellurite resistance protein TehB - - - 0.0000315 50.0
TLS2_k127_6141937_2 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 339.0
TLS2_k127_6141937_3 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 326.0
TLS2_k127_6141937_4 PFAM alpha beta hydrolase fold K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007179 280.0
TLS2_k127_6141937_5 PFAM alpha beta hydrolase fold K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000814 226.0
TLS2_k127_6141937_6 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.0000000000000000000000000000000000000000000000000000000008296 208.0
TLS2_k127_6141937_7 TIGRFAM Ferrous iron transport protein B K04759 - - 0.0000000000000000000000000000000000000000000000000000001618 199.0
TLS2_k127_6141937_8 -acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000001466 198.0
TLS2_k127_6141937_9 Type II secretion system (T2SS), protein F - - - 0.000000000193 66.0
TLS2_k127_6186011_0 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 313.0
TLS2_k127_6186011_1 SPFH domain-Band 7 family - - - 0.00000000000000000000000000000000000000000000000000000013 208.0
TLS2_k127_6186011_2 - - - - 0.000000000000000000000000000875 115.0
TLS2_k127_6186011_3 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000001694 122.0
TLS2_k127_6186011_4 Protein of unknown function (DUF2283) - - - 0.000000000000000000000000179 106.0
TLS2_k127_6186011_5 - - - - 0.0000000000000000634 87.0
TLS2_k127_6205037_0 amidophosphoribosyltransferase activity K00764 GO:0000003,GO:0000082,GO:0000278,GO:0001655,GO:0001822,GO:0003006,GO:0003674,GO:0003824,GO:0004044,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006144,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006543,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0007049,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007565,GO:0007568,GO:0007589,GO:0007595,GO:0008150,GO:0008152,GO:0008340,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009112,GO:0009113,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009719,GO:0009725,GO:0009790,GO:0009987,GO:0010033,GO:0010243,GO:0010259,GO:0016043,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0019953,GO:0022402,GO:0022412,GO:0022414,GO:0022607,GO:0030154,GO:0030879,GO:0031099,GO:0031100,GO:0032501,GO:0032502,GO:0032504,GO:0032868,GO:0032869,GO:0032870,GO:0034641,GO:0034654,GO:0035690,GO:0040016,GO:0042221,GO:0042440,GO:0042493,GO:0043434,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0044703,GO:0044706,GO:0044770,GO:0044772,GO:0044843,GO:0046040,GO:0046112,GO:0046148,GO:0046390,GO:0046395,GO:0046483,GO:0046903,GO:0048468,GO:0048477,GO:0048513,GO:0048609,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050878,GO:0050896,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051301,GO:0051704,GO:0051716,GO:0055086,GO:0060135,GO:0065003,GO:0065007,GO:0065008,GO:0070887,GO:0071310,GO:0071375,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0072001,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1903047 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000353 485.0
TLS2_k127_6205037_1 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 445.0
TLS2_k127_6205037_2 SMART tyrosine protein kinase K08884 - 2.7.11.1 0.0000000000000000000000000000000000000005786 171.0
TLS2_k127_6205037_3 SIR2-like domain - - - 0.000001099 60.0
TLS2_k127_6217937_0 PFAM helix-turn-helix domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005649 373.0
TLS2_k127_6217937_1 ATPase domain predominantly from Archaea K06921 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006505 302.0
TLS2_k127_6217937_2 ATPase domain predominantly from Archaea K06921 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001823 271.0
TLS2_k127_6217937_3 Shikimate kinase - - - 0.00000000000000000000000000000000000000000000000000000001815 205.0
TLS2_k127_6217937_4 PFAM Plasmid pRiA4b ORF-3-like protein - - - 0.0000000000000000000000000000000000000000598 156.0
TLS2_k127_6217937_5 CAAX protease self-immunity - - - 0.000000000000000000000000000000000000132 153.0
TLS2_k127_6217937_6 CAAX protease self-immunity - - - 0.00000000000000000000000000006237 127.0
TLS2_k127_6217937_7 metal-dependent membrane protease - - - 0.000000000000000001356 96.0
TLS2_k127_6217937_8 Transposase - - - 0.0000001525 54.0
TLS2_k127_622145_0 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 355.0
TLS2_k127_622145_1 PFAM O-methyltransferase K00588 - 2.1.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003945 304.0
TLS2_k127_622145_2 TIGRFAM polymorphic outer membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000101 259.0
TLS2_k127_622145_3 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000002721 81.0
TLS2_k127_6227241_0 fructose-bisphosphate aldolase, class II, yeast E. coli subtype K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 559.0
TLS2_k127_6227241_1 Haloacid dehalogenase-like hydrolase K07025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000241 260.0
TLS2_k127_6227241_2 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01007,K08483 - 2.7.3.9,2.7.9.2 0.00000000000000004007 83.0
TLS2_k127_6232275_0 Belongs to the IlvD Edd family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 403.0
TLS2_k127_6232275_1 SMART AAA ATPase K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003881 369.0
TLS2_k127_6232275_2 spore germination - - - 0.000000000000000000000000000000000000000000000000000000000000000000001979 247.0
TLS2_k127_6232275_3 Sulfotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000013 204.0
TLS2_k127_6232275_4 restriction endodeoxyribonuclease activity - - - 0.0000000000000000000000000000000000000000000936 174.0
TLS2_k127_6232275_5 PFAM thioesterase superfamily protein - - - 0.0000000000000000000000000000000000000000001372 163.0
TLS2_k127_6232275_6 ATPase associated with various cellular activities, AAA_5 K07452 - - 0.0000000000000000000000000000001008 138.0
TLS2_k127_6242285_0 nitrogen compound transport K02033 - - 0.0000000000000000000000000000000000000000000000000000000000009955 223.0
TLS2_k127_6242285_1 ABC-type dipeptide oligopeptide nickel transport K02034 - - 0.000000000000000000000000000000000000000000000000000000238 207.0
TLS2_k127_6242285_2 COG0791 Cell wall-associated hydrolases (invasion-associated proteins) - - - 0.00001436 49.0
TLS2_k127_6242285_3 Cytochrome c - - - 0.00002168 55.0
TLS2_k127_6244339_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 5.39e-213 674.0
TLS2_k127_6244339_1 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008542 589.0
TLS2_k127_6244339_2 MgtE intracellular N domain K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008356 350.0
TLS2_k127_6244339_3 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001189 265.0
TLS2_k127_6244339_4 - - - - 0.0000000000000000000000000000000000000000000171 167.0
TLS2_k127_6244339_5 - - - - 0.00000000000000000000000000000003769 137.0
TLS2_k127_6244339_6 2'-5' RNA ligase superfamily - - - 0.0000000000000000000000000000002893 129.0
TLS2_k127_6244339_7 PFAM von Willebrand factor type A K07114 - - 0.00000000004565 68.0
TLS2_k127_6244339_8 Winged helix DNA-binding domain - - - 0.0000000003042 64.0
TLS2_k127_6244339_9 alcohol dehydrogenase - - - 0.0000001198 62.0
TLS2_k127_6247418_0 Polysaccharide biosynthesis protein K02851 - 2.7.8.33,2.7.8.35 6.758e-230 724.0
TLS2_k127_6247418_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 494.0
TLS2_k127_6247418_2 pyruvate kinase activity K00873,K00958 GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009986,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0022607,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065 2.7.1.40,2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009288 417.0
TLS2_k127_6247418_3 - - - - 0.0000000000000785 78.0
TLS2_k127_6247418_4 gas vesicle protein - - - 0.0001105 50.0
TLS2_k127_6260117_0 Fungalysin metallopeptidase (M36) K01417 - - 7.578e-194 646.0
TLS2_k127_6260117_1 ROK family K00847 - 2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 413.0
TLS2_k127_6260117_2 MFS/sugar transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 333.0
TLS2_k127_6260117_3 PFAM peptidase S1 and S6, chymotrypsin Hap - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 312.0
TLS2_k127_6260117_4 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000004826 151.0
TLS2_k127_6260117_5 PQQ-like domain - - - 0.00000000000001895 80.0
TLS2_k127_626111_0 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009048 434.0
TLS2_k127_626629_0 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000001003 157.0
TLS2_k127_6274274_0 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006678 369.0
TLS2_k127_6274274_1 Glycosyl hydrolases family 2 K01192 - 3.2.1.25 0.00000000000000000000000000000000000000000317 160.0
TLS2_k127_6274653_0 Aldehyde oxidase and xanthine dehydrogenase a b hammerhead K03520,K11177 - 1.17.1.4,1.2.5.3 0.0 1223.0
TLS2_k127_6274653_1 Peptidase S9, prolyl oligopeptidase active site domain protein K01322 - 3.4.21.26 3.703e-261 821.0
TLS2_k127_6274653_2 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008194 344.0
TLS2_k127_6274653_3 metallochaperone-like domain K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000182 268.0
TLS2_k127_6274653_4 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000004955 243.0
TLS2_k127_6274653_5 Cell wall hydrolase K01449 - 3.5.1.28 0.0004279 51.0
TLS2_k127_6293229_0 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 421.0
TLS2_k127_6293229_1 Sigma-70, region 4 K03088 - - 0.000000000000000000000002281 108.0
TLS2_k127_6293229_2 FecR protein - - - 0.0000000000000006862 92.0
TLS2_k127_6302472_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009075 525.0
TLS2_k127_6302472_1 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 456.0
TLS2_k127_6302472_2 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000005498 246.0
TLS2_k127_6302472_3 Sigma-70, region 4 K03088 - - 0.00000000000000000004381 98.0
TLS2_k127_6302472_4 Peptidase family M1 domain - - - 0.0000000000000001872 93.0
TLS2_k127_6302472_5 peptidyl-tyrosine sulfation - - - 0.0000000007539 64.0
TLS2_k127_6343601_0 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 1.063e-209 666.0
TLS2_k127_6343601_1 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009668 605.0
TLS2_k127_6343601_2 Transcriptional regulator K03603,K05799,K22104 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010563,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0019395,GO:0019752,GO:0030258,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032787,GO:0032991,GO:0032993,GO:0034440,GO:0042304,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045723,GO:0045833,GO:0045834,GO:0045892,GO:0045893,GO:0045923,GO:0045934,GO:0045935,GO:0045936,GO:0046889,GO:0046890,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051252,GO:0051253,GO:0051254,GO:0055114,GO:0060255,GO:0062012,GO:0062013,GO:0065007,GO:0071071,GO:0071072,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1903725,GO:1903726,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000005058 230.0
TLS2_k127_6343601_3 gluconolactonase activity K13276,K14274 GO:0005575,GO:0005576 - 0.0000008589 60.0
TLS2_k127_6349493_0 Belongs to the GcvT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 552.0
TLS2_k127_6349493_1 Electron transfer flavoprotein K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005107 312.0
TLS2_k127_6349493_2 Electron transfer flavoprotein, beta subunit K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008793 265.0
TLS2_k127_6349493_3 glycine betaine transport K02002 - - 0.0000000000000000000000000000000000000000000000000005577 197.0
TLS2_k127_6353101_0 PFAM ABC transporter transmembrane region K06147,K18890 - - 6.955e-265 829.0
TLS2_k127_6353101_1 PFAM ABC transporter transmembrane region K06147 - - 3.034e-235 741.0
TLS2_k127_6353101_2 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000008415 241.0
TLS2_k127_6353101_3 domain, Protein - - - 0.00000000000000000000000000000000002347 156.0
TLS2_k127_6353101_4 Protein of unknown function (DUF2089) - - - 0.0000000000000000003713 93.0
TLS2_k127_6353101_5 - - - - 0.000000002975 66.0
TLS2_k127_6363100_0 Cys/Met metabolism PLP-dependent enzyme K10907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005018 430.0
TLS2_k127_6363100_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002091 271.0
TLS2_k127_6363100_2 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000007947 241.0
TLS2_k127_6373839_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 484.0
TLS2_k127_6373839_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 406.0
TLS2_k127_6373839_2 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007657 388.0
TLS2_k127_6373839_3 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000008871 237.0
TLS2_k127_6373839_4 response regulator receiver - - - 0.000000000000000000000000000000000000007375 156.0
TLS2_k127_6373839_5 Histidine kinase - - - 0.000000000000000000000000000002076 126.0
TLS2_k127_6373839_7 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000264 61.0
TLS2_k127_6374607_0 Isocitrate/isopropylmalate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008187 504.0
TLS2_k127_6374607_1 L-glyceraldehyde 3-phosphate reductase K19265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005195 483.0
TLS2_k127_6374607_10 positive regulation of growth - - - 0.0008714 46.0
TLS2_k127_6374607_2 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 369.0
TLS2_k127_6374607_3 PFAM Methicillin resistance protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 321.0
TLS2_k127_6374607_4 Methionine aminopeptidase K01265 GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001725 276.0
TLS2_k127_6374607_5 PFAM Methicillin resistance protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001609 272.0
TLS2_k127_6374607_6 PFAM metallophosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000009035 237.0
TLS2_k127_6374607_7 membrane - - - 0.0000000000000000000000000000002426 128.0
TLS2_k127_6374607_8 Zn-ribbon protein possibly nucleic acid-binding K07164 - - 0.00000000000000000000003824 108.0
TLS2_k127_6374607_9 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000002142 98.0
TLS2_k127_6380924_0 Tryptophan halogenase K14257 - 1.14.19.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 507.0
TLS2_k127_6380924_1 Globin - - - 0.00000000000000000000000000000000000002048 146.0
TLS2_k127_6394503_0 PFAM Dak phosphatase K07030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 445.0
TLS2_k127_6394503_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001554 285.0
TLS2_k127_6394503_2 PFAM GHMP kinase K00869 - 2.7.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002786 282.0
TLS2_k127_6394503_3 Uncharacterised protein, DegV family COG1307 - - - 0.00000000000000000000000000000000000000000000000000111 193.0
TLS2_k127_6394503_4 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000118 156.0
TLS2_k127_6394503_5 Asp23 family, cell envelope-related function - - - 0.00000000000000000000002217 104.0
TLS2_k127_6411208_0 glycerophosphodiester transmembrane transport K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 287.0
TLS2_k127_6411208_1 PFAM glycosidase PH1107-related K18785,K20885 - 2.4.1.319,2.4.1.320,2.4.1.339,2.4.1.340 0.000006165 53.0
TLS2_k127_6411208_2 - - - - 0.000579 49.0
TLS2_k127_6415386_0 carbohydrate transport K02027 - - 3.94e-209 659.0
TLS2_k127_6415386_1 PFAM ABC transporter related K10112 GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015399,GO:0015405,GO:0015430,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264,GO:1901505 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004067 584.0
TLS2_k127_6415386_2 transmembrane transport K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17242,K17312,K17316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 557.0
TLS2_k127_6415386_3 glycerophosphodiester transmembrane transport K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 415.0
TLS2_k127_6415386_4 PFAM glycoside hydrolase family 38 K01191 - 3.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 430.0
TLS2_k127_6426624_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 524.0
TLS2_k127_6426624_1 deaminated base DNA N-glycosylase activity K03648,K21929 - 3.2.2.27 0.0000000000000000000000000000000000000001133 159.0
TLS2_k127_6426624_2 PFAM lipopolysaccharide biosynthesis protein K08253 - 2.7.10.2 0.0000000000000000000000000000000000000001562 161.0
TLS2_k127_6426624_3 PFAM Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000007229 128.0
TLS2_k127_6433242_0 Calcineurin-like phosphoesterase - - - 0.000000000000000001066 102.0
TLS2_k127_6433242_1 Calcineurin-like phosphoesterase - - - 0.000000000000000002448 100.0
TLS2_k127_6433242_2 Involved in the tonB-independent uptake of proteins - - - 0.000000000007575 79.0
TLS2_k127_6433242_3 phosphoesterase, PA-phosphatase related - - - 0.0006898 50.0
TLS2_k127_6434946_0 Monooxygenase fad-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 394.0
TLS2_k127_6434946_1 Thermophilic metalloprotease (M29) K19689 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 294.0
TLS2_k127_643827_0 GTP cyclohydrolase II K01497,K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 453.0
TLS2_k127_643827_1 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005801 321.0
TLS2_k127_643827_2 TIGRFAM riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000007001 240.0
TLS2_k127_643827_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.00000000000000000000000000000000000000000000000000000000001924 209.0
TLS2_k127_643827_4 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.0000000000000000000000000000000000000000000000000002424 189.0
TLS2_k127_643827_5 Phosphonate ABC transporter K02044 - - 0.000000000000000000000000000000000006684 151.0
TLS2_k127_643827_6 cellulose binding - - - 0.00000000000000000000000000008617 128.0
TLS2_k127_643827_7 RibD C-terminal domain K11752 - 1.1.1.193,3.5.4.26 0.000000000001191 69.0
TLS2_k127_6455046_0 KR domain K00034 - 1.1.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006123 279.0
TLS2_k127_6455046_1 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000235 245.0
TLS2_k127_6455046_2 PFAM MazG nucleotide pyrophosphohydrolase - - - 0.00000000000000000000000000000000000000000000000001293 183.0
TLS2_k127_6455046_4 PIN domain K07063 - - 0.0000000000000002747 84.0
TLS2_k127_6455046_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000001167 86.0
TLS2_k127_6455046_6 FtsX-like permease family K02004 - - 0.0000000000005727 83.0
TLS2_k127_6459726_0 PFAM short-chain dehydrogenase reductase SDR - GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 306.0
TLS2_k127_6459726_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001306 289.0
TLS2_k127_6459726_2 Protein of unknown function DUF86 - - - 0.00000000000000000000000000000000000000000002378 165.0
TLS2_k127_6459726_3 - - - - 0.000000000000000000000000000000000000000001022 161.0
TLS2_k127_6459726_4 CAAX protease self-immunity K07052 - - 0.0000000000000000000000003907 106.0
TLS2_k127_6459726_6 PFAM N-6 DNA methylase K03427 - 2.1.1.72 0.000000000000003766 78.0
TLS2_k127_6467639_0 transaminase activity K00375 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 524.0
TLS2_k127_6467639_1 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000001229 182.0
TLS2_k127_6467639_2 FG-GAP repeat - - - 0.000000000000000000000000000004242 130.0
TLS2_k127_6482874_0 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005355 293.0
TLS2_k127_6482874_1 COG0616 Periplasmic serine proteases (ClpP class) K04773 - - 0.00000000000000000000000000000000000000004507 162.0
TLS2_k127_6482874_2 - - - - 0.000000000000001417 91.0
TLS2_k127_6487869_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008122 443.0
TLS2_k127_6487869_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000001878 78.0
TLS2_k127_6487869_2 family 18 - - - 0.0000007885 61.0
TLS2_k127_6500617_0 serine-type endopeptidase activity K01312,K14647 GO:0005575,GO:0005576 3.4.21.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007426 491.0
TLS2_k127_6500617_1 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009181 314.0
TLS2_k127_6500617_2 Domain of unknown function (DUF4351) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001901 243.0
TLS2_k127_6500617_3 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.000000000000000000000000000000000000000000001736 190.0
TLS2_k127_6500617_4 NACHT domain - - - 0.000000001595 69.0
TLS2_k127_6503218_0 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 319.0
TLS2_k127_6503218_1 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000351 228.0
TLS2_k127_6503218_2 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000002388 97.0
TLS2_k127_6517831_0 COGs COG3321 Polyketide synthase modules and related protein - - - 0.0 1451.0
TLS2_k127_6517831_1 polyketide synthase - - - 0.0 1414.0
TLS2_k127_6517831_2 TIGRFAM amino acid adenylation domain K16132 - - 1.883e-306 1034.0
TLS2_k127_6517831_3 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 345.0
TLS2_k127_6534574_0 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 3.89e-213 671.0
TLS2_k127_6534574_1 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - 0.00000000000000000000000000000000000000000000000000000002436 203.0
TLS2_k127_6534574_2 Threonyl and Alanyl tRNA synthetase second additional domain K07050 - - 0.0000000000000000000000000000000000000000000000002539 179.0
TLS2_k127_6534574_3 Zincin-like metallopeptidase - - - 0.000000000000000000005958 94.0
TLS2_k127_6548675_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 6.541e-206 673.0
TLS2_k127_6548675_1 tRNA synthetase, class II (D, K and N) K01893 - 6.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007858 586.0
TLS2_k127_6548675_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000008594 166.0
TLS2_k127_6548675_3 NUDIX domain - - - 0.00000000000000001019 86.0
TLS2_k127_6550520_0 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 315.0
TLS2_k127_6550520_1 PFAM Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001211 274.0
TLS2_k127_6550520_3 Psort location Cytoplasmic, score - - - 0.0002311 48.0
TLS2_k127_656463_0 DNA polymerase K02337,K14162 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 547.0
TLS2_k127_656463_1 glycosyl K11055 - - 0.00000000000000000000000000000000000001877 154.0
TLS2_k127_656463_2 Pfam:Arch_ATPase - - - 0.00000000000000000000000001037 130.0
TLS2_k127_656463_3 - - - - 0.00000000000000000000000001119 114.0
TLS2_k127_656463_4 - K06921 - - 0.0000000000000000007159 101.0
TLS2_k127_656463_5 Transcriptional regulatory protein, C terminal K02483,K07658 - - 0.0000004488 63.0
TLS2_k127_6574704_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 8.527e-226 715.0
TLS2_k127_6574704_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 398.0
TLS2_k127_6574704_2 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007841 371.0
TLS2_k127_6574704_3 PFAM PSP1 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000252 266.0
TLS2_k127_6574704_4 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00338,K03615 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000004491 229.0
TLS2_k127_6574704_5 TIGRFAM metal dependent phophohydrolase - - - 0.000000000000000000000000000000000000000000000000000005016 196.0
TLS2_k127_6574704_6 PFAM RNA binding S1 domain protein - - - 0.00000000000000000000000000000000000000001513 163.0
TLS2_k127_6581589_0 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000489 430.0
TLS2_k127_6581589_1 Glycosyl hydrolase family 65, C-terminal domain K04844,K05342,K10231 - 2.4.1.230,2.4.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009151 322.0
TLS2_k127_6581589_2 helix_turn _helix lactose operon repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 322.0
TLS2_k127_6596738_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004609 614.0
TLS2_k127_6596738_1 Bacterial extracellular solute-binding protein K02055,K05777 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004065 437.0
TLS2_k127_6596738_2 KR domain K00046 - 1.1.1.69 0.0000000000000000000000000000000000000000000000000000000000000000000001437 247.0
TLS2_k127_6596738_3 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000006861 219.0
TLS2_k127_6596738_4 PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein K01739 - 2.5.1.48 0.0000000000000000003199 90.0
TLS2_k127_6601479_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1259.0
TLS2_k127_6601479_1 PFAM Acetyltransferase (GNAT) family K18815 - 2.3.1.82 0.000000000000000000000000000000000000000000000000000000000000000000008135 238.0
TLS2_k127_6607536_0 Glycyl-tRNA synthetase alpha subunit K14164 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006626 407.0
TLS2_k127_6607536_1 - - - - 0.0000000000004242 69.0
TLS2_k127_6609908_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002136 267.0
TLS2_k127_6609908_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009395 263.0
TLS2_k127_6609908_2 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000000000000003533 181.0
TLS2_k127_6609908_3 Domain of unknown function (DUF1992) K19373 - - 0.000000000000000000000000000005724 125.0
TLS2_k127_6609908_4 domain, Protein - - - 0.00000000000000000000000005533 121.0
TLS2_k127_6609908_5 integral membrane protein - - - 0.000000000628 66.0
TLS2_k127_6609908_6 COGs COG1120 ABC-type cobalamin Fe3 -siderophores transport systems ATPase components K02013 - 3.6.3.34 0.000000002929 60.0
TLS2_k127_6631069_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 403.0
TLS2_k127_6631069_1 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000000000000000000000000000000000001485 157.0
TLS2_k127_6631069_2 Smr domain - - - 0.00000000000000000000000000000000005334 135.0
TLS2_k127_6631069_3 Haloacid dehalogenase-like hydrolase K02566 - - 0.0000000000000000002326 90.0
TLS2_k127_6652412_0 Pyridoxal-phosphate dependent enzyme K01697,K01738 - 2.5.1.47,4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 545.0
TLS2_k127_6652412_1 Chitinase class I K03791 - - 0.0000000000000000000000000000128 130.0
TLS2_k127_6658462_0 Glycogen debranching enzyme N terminal - - - 8.925e-279 871.0
TLS2_k127_6658462_1 Elongator protein 3, MiaB family, Radical SAM - - - 2.848e-256 805.0
TLS2_k127_6658462_2 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000001259 239.0
TLS2_k127_6658462_3 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.00000000000000000000000000000000000000000000000000008217 197.0
TLS2_k127_6658462_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000004202 182.0
TLS2_k127_6658462_5 Cyclic nucleotide-monophosphate binding domain K04739 GO:0000166,GO:0000187,GO:0001932,GO:0001933,GO:0001934,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0005952,GO:0006469,GO:0007154,GO:0007267,GO:0008150,GO:0008603,GO:0009653,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010468,GO:0010562,GO:0010563,GO:0010604,GO:0010605,GO:0010628,GO:0010646,GO:0010647,GO:0010738,GO:0015630,GO:0017076,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0023051,GO:0023052,GO:0023056,GO:0030154,GO:0030234,GO:0030291,GO:0030435,GO:0030551,GO:0030552,GO:0030554,GO:0030587,GO:0031154,GO:0031156,GO:0031285,GO:0031288,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033673,GO:0033674,GO:0034236,GO:0036094,GO:0042325,GO:0042326,GO:0042327,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043405,GO:0043406,GO:0043408,GO:0043410,GO:0043549,GO:0043900,GO:0043934,GO:0043949,GO:0044092,GO:0044093,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0051018,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051246,GO:0051247,GO:0051248,GO:0051338,GO:0051347,GO:0051348,GO:0051703,GO:0051704,GO:0060255,GO:0061939,GO:0065007,GO:0065009,GO:0071900,GO:0071901,GO:0071902,GO:0080090,GO:0090702,GO:0097159,GO:0097367,GO:0098772,GO:0099120,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:2000479,GO:2000480 - 0.0000000000000000000001249 110.0
TLS2_k127_6665194_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 1.774e-275 863.0
TLS2_k127_6665194_1 ATP synthesis coupled electron transport K00336 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944 1.6.5.3 6.882e-262 832.0
TLS2_k127_6665194_10 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000994 133.0
TLS2_k127_6665194_11 protein conserved in bacteria (DUF2344) - - - 0.00000000000000000000000002443 117.0
TLS2_k127_6665194_12 Acyl-CoA synthetase (NDP forming) K09181 - - 0.00000000000000002337 90.0
TLS2_k127_6665194_13 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.0000000000000001189 89.0
TLS2_k127_6665194_2 proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003904 503.0
TLS2_k127_6665194_3 PFAM NADH-Ubiquinone oxidoreductase (complex I), chain 5 L domain protein K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 505.0
TLS2_k127_6665194_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 464.0
TLS2_k127_6665194_5 LysM domain K03046,K03641,K08642 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 407.0
TLS2_k127_6665194_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 341.0
TLS2_k127_6665194_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K05580 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001877 255.0
TLS2_k127_6665194_8 Phosphodiester glycosidase - - - 0.0000000000000000000000000000000000000000000000000000003701 204.0
TLS2_k127_6665194_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000000000000000003542 134.0
TLS2_k127_6682709_0 peptidase M24 K01271 - 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 319.0
TLS2_k127_6682709_1 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000008503 192.0
TLS2_k127_6682709_2 Biotin carboxylase K01941 - 6.3.4.6 0.00000000005471 70.0
TLS2_k127_6686326_0 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01897 - 6.2.1.3 6.879e-223 701.0
TLS2_k127_6686326_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 427.0
TLS2_k127_6686326_2 PFAM O-antigen polymerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 355.0
TLS2_k127_6686326_3 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 351.0
TLS2_k127_6686326_4 Phosphopantetheine attachment site - - - 0.000000000000000000008563 94.0
TLS2_k127_6688080_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007683 548.0
TLS2_k127_6688080_1 PFAM RNA binding S1 domain protein K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000008691 243.0
TLS2_k127_6693577_0 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 323.0
TLS2_k127_6693577_1 Hsp70 protein K04046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004644 344.0
TLS2_k127_6693577_2 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - 0.000000000000000000000000000000000000000000000000000000005513 203.0
TLS2_k127_6693577_3 Cytochrome c oxidase caa3-type, assembly factor K02351 - - 0.00000000000000003077 91.0
TLS2_k127_6693577_4 BlaR1 peptidase M56 - - - 0.0000000000000002056 84.0
TLS2_k127_6694226_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 432.0
TLS2_k127_6694226_1 PFAM Radical SAM domain protein K22227 - - 0.000000000000000000000000000000000000000000001958 181.0
TLS2_k127_6694226_2 PhoQ Sensor - - - 0.0000000000000000000004189 112.0
TLS2_k127_6702129_0 PFAM GHMP kinase K07031 - 2.7.1.168 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005181 454.0
TLS2_k127_6702129_1 PFAM sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 451.0
TLS2_k127_6702129_2 PFAM lipopolysaccharide biosynthesis protein K08253,K16554,K16692 - 2.7.10.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 321.0
TLS2_k127_6702129_3 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000001776 211.0
TLS2_k127_6702129_4 domain protein K01212,K01317,K12287,K20276 - 3.2.1.65,3.4.21.10 0.0000000000000000000000000003302 133.0
TLS2_k127_6706223_0 PHP-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001837 282.0
TLS2_k127_6706223_1 PFAM Diacylglycerol kinase, catalytic - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000154 274.0
TLS2_k127_6706223_2 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000000000008589 199.0
TLS2_k127_6706223_3 Histidine kinase K07683 - 2.7.13.3 0.00000000000000000000000000000000000000003068 173.0
TLS2_k127_6706223_4 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000001004 118.0
TLS2_k127_6707242_0 Domain of unknown function (DUF4347) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 369.0
TLS2_k127_6716184_0 Membrane - - - 0.000000000000000000000000000000000000000000000000006283 199.0
TLS2_k127_6716184_1 TIGRFAM capsular exopolysaccharide family K08253 - 2.7.10.2 0.00000000000000000000000000000002347 128.0
TLS2_k127_6717076_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1390.0
TLS2_k127_6717076_1 P22_AR N-terminal domain - - - 0.0000000000000004014 85.0
TLS2_k127_6727995_0 pyridine nucleotide-disulphide oxidoreductase - GO:0003674,GO:0003824,GO:0005575,GO:0006082,GO:0006629,GO:0006790,GO:0008146,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016782,GO:0031224,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044272,GO:0044281,GO:0044425,GO:0046505,GO:0046506,GO:0071704,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 365.0
TLS2_k127_6727995_1 Glycosyltransferase family 28 N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 319.0
TLS2_k127_6727995_2 transferase activity, transferring alkyl or aryl (other than methyl) groups K15911,K22313 GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016101,GO:0016102,GO:0016114,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0035440,GO:0042578,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0075136,GO:1901576 3.1.7.12,3.1.7.8,3.1.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000003745 250.0
TLS2_k127_6727995_3 protein histidine kinase activity K01768,K11527,K18143 - 2.7.13.3,4.6.1.1 0.00000000000000000000000000000000000000000000000000000000001558 233.0
TLS2_k127_6727995_4 protein histidine kinase activity K01768,K11527,K18143 - 2.7.13.3,4.6.1.1 0.000000000000000000000000000000000000004079 162.0
TLS2_k127_6727995_5 Belongs to the terpene synthase family K04120 GO:0000287,GO:0001101,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006720,GO:0006721,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009507,GO:0009536,GO:0009685,GO:0009686,GO:0009719,GO:0009725,GO:0009739,GO:0009740,GO:0009755,GO:0009905,GO:0009987,GO:0010033,GO:0010476,GO:0010817,GO:0016053,GO:0016101,GO:0016102,GO:0016114,GO:0016853,GO:0016872,GO:0019752,GO:0023052,GO:0032870,GO:0033993,GO:0042221,GO:0042445,GO:0042446,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071229,GO:0071310,GO:0071370,GO:0071396,GO:0071495,GO:0071704,GO:1901576,GO:1901700,GO:1901701 5.5.1.13 0.00000000000000000000000000000000004669 153.0
TLS2_k127_6727995_6 histidine kinase A domain protein - - - 0.0000000000000000000009654 108.0
TLS2_k127_6729151_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 4.321e-282 889.0
TLS2_k127_6729151_1 Pyridine nucleotide-disulphide oxidoreductase dimerisation region K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007879 589.0
TLS2_k127_6729151_2 Domain of unknown function (DUF4347) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 357.0
TLS2_k127_6729151_3 PFAM cytoplasmic peptidoglycan synthetase domain protein K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 321.0
TLS2_k127_6729151_4 Belongs to the HesB IscA family K13628,K15724 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564 - 0.00000000000000000000000000000000002716 139.0
TLS2_k127_6729151_5 Uncharacterized conserved protein (DUF2203) - - - 0.00000000000000000000000000116 116.0
TLS2_k127_6729151_6 - - - - 0.000000000000007677 79.0
TLS2_k127_6733702_0 Peptidase family S41 - - - 3.752e-236 754.0
TLS2_k127_6733702_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 GO:0000049,GO:0000166,GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046983,GO:0070905,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 460.0
TLS2_k127_6733702_10 Polysaccharide biosynthesis protein - - - 0.000000000000000008515 93.0
TLS2_k127_6733702_2 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008155 351.0
TLS2_k127_6733702_3 Two component transcriptional regulator, winged helix family K07669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 317.0
TLS2_k127_6733702_4 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004888 326.0
TLS2_k127_6733702_5 WD40-like Beta Propeller Repeat K03641 - - 0.0000000000000000000000000000000000000000000000000000000003133 221.0
TLS2_k127_6733702_6 Domain of unknown function (DUF1980) - - - 0.00000000000000000000000000000000000000000000000000002089 198.0
TLS2_k127_6733702_7 phosphatidate phosphatase activity K19302 - 3.6.1.27 0.00000000000000000000000000000000000000002658 166.0
TLS2_k127_6733702_8 translation release factor activity - - - 0.000000000000000000000000000000000000001132 148.0
TLS2_k127_6733702_9 PspC domain - - - 0.000000000000000000000000002988 115.0
TLS2_k127_6736315_0 CoA-ligase K02381 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006367 524.0
TLS2_k127_6737875_0 SMART Elongator protein 3 MiaB NifB - - - 2.036e-232 729.0
TLS2_k127_6737875_1 PFAM fumarate lyase K01679 - 4.2.1.2 2.913e-219 688.0
TLS2_k127_6737875_10 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000127 162.0
TLS2_k127_6737875_11 Mov34 MPN PAD-1 family K21140 - 3.13.1.6 0.000000000000000000000000000485 118.0
TLS2_k127_6737875_12 acyl-phosphate glycerol-3-phosphate acyltransferase activity K08591 - 2.3.1.15 0.000000000000000000000000001609 121.0
TLS2_k127_6737875_13 PFAM blue (type 1) copper domain protein K00368 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 0.0000000000000002481 85.0
TLS2_k127_6737875_14 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000005553 64.0
TLS2_k127_6737875_15 Polysaccharide biosynthesis protein - - - 0.00000003997 65.0
TLS2_k127_6737875_16 O-antigen ligase - - - 0.00001823 57.0
TLS2_k127_6737875_2 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 488.0
TLS2_k127_6737875_3 Peptidase dimerisation domain protein K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 387.0
TLS2_k127_6737875_4 nucleotidyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 308.0
TLS2_k127_6737875_5 LPPG Fo 2-phospho-L-lactate transferase K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 289.0
TLS2_k127_6737875_6 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003068 279.0
TLS2_k127_6737875_7 MOSC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000133 265.0
TLS2_k127_6737875_8 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000004115 248.0
TLS2_k127_6737875_9 ABC-type dipeptide transport system periplasmic component K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000009667 255.0
TLS2_k127_6762786_0 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006899 489.0
TLS2_k127_6762786_1 Sterol carrier protein domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 364.0
TLS2_k127_6762786_2 YacP-like NYN domain K06962 - - 0.00000000000000000000000003097 118.0
TLS2_k127_6762786_3 Predicted membrane protein (DUF2085) - - - 0.0000000000000000000000001158 116.0
TLS2_k127_6762786_4 Fungalysin metallopeptidase (M36) - - - 0.0000000000000000000000002714 107.0
TLS2_k127_6766288_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 446.0
TLS2_k127_6766288_1 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005963 459.0
TLS2_k127_6766288_2 CpXC protein - - - 0.0000000000000000000000000000000000000000000000000000000000000004383 237.0
TLS2_k127_6766288_3 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179 - 3.2.1.4 0.000000000000000000000000000000000000000000000007964 195.0
TLS2_k127_6766288_4 Belongs to the peptidase S8 family K08651,K14743 - 3.4.21.66 0.000000000000000000000000000000000000000000001434 188.0
TLS2_k127_6766288_5 Aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.00000000001597 66.0
TLS2_k127_6766288_6 TrkA-N domain K03499 - - 0.00000000002515 76.0
TLS2_k127_6773532_0 (FHA) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 477.0
TLS2_k127_6773532_1 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000658 310.0
TLS2_k127_6773532_2 histidine kinase, dimerisation and phosphoacceptor region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003649 280.0
TLS2_k127_6773532_3 NB-ARC domain - - - 0.00000000000000000000000000000000000000000000000000004177 203.0
TLS2_k127_6773532_4 - - - - 0.00000000000000000000000000000000781 134.0
TLS2_k127_6773532_5 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000001563 96.0
TLS2_k127_6773532_6 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000007797 67.0
TLS2_k127_6773532_7 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769 - 5.2.1.8 0.0000000002552 72.0
TLS2_k127_6773532_8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000001994 54.0
TLS2_k127_6777938_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K01083,K06131,K06915 - 3.1.3.8 0.00000000000000000000000000007992 125.0
TLS2_k127_6777938_1 Beta-lactamase K01286,K17836 - 3.4.16.4,3.5.2.6 0.000000000000000004335 98.0
TLS2_k127_6782887_0 PFAM glycosyl transferase, family 51 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009585 515.0
TLS2_k127_6782887_1 FKBP-type peptidyl-prolyl cis-trans isomerase K03775 - 5.2.1.8 0.00000000000000000000000000000000000000003412 157.0
TLS2_k127_6782887_2 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000000000003595 103.0
TLS2_k127_6789519_0 trimethylamine methyltransferase K14083 - 2.1.1.250 3.254e-201 638.0
TLS2_k127_6789519_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009981 399.0
TLS2_k127_6789519_2 Serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004867 284.0
TLS2_k127_6795408_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000001262 81.0
TLS2_k127_6795408_1 - - - - 0.0000002704 56.0
TLS2_k127_6795408_2 SMART zinc finger, RanBP2-type - - - 0.00001215 58.0
TLS2_k127_6798616_0 PFAM Transketolase central region K00615,K11381 - 1.2.4.4,2.2.1.1 9.183e-312 976.0
TLS2_k127_6798616_1 WD domain, G-beta repeat - - - 5.896e-211 704.0
TLS2_k127_6798616_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005929 624.0
TLS2_k127_6798616_3 ABC transporter transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005506 549.0
TLS2_k127_6798616_4 ABC transporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005438 544.0
TLS2_k127_6798616_5 Catalytic domain of components of various dehydrogenase complexes K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 381.0
TLS2_k127_6798616_6 Protein of unknown function (DUF554) K07150 - - 0.000000000000000000000000000000000000000000000000000000000000001739 226.0
TLS2_k127_6798616_7 ErfK ybiS ycfS ynhG family protein - - - 0.000000000000000000000000000000000000000005714 168.0
TLS2_k127_6798616_8 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00005813 54.0
TLS2_k127_6803664_0 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000003047 183.0
TLS2_k127_6803664_1 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000000000000007202 155.0
TLS2_k127_6803664_2 Glyoxalase-like domain K08234 - - 0.0000000000000000000000000000000000003901 140.0
TLS2_k127_6803664_3 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000000000000004543 100.0
TLS2_k127_6803664_4 Acetyltransferase (GNAT) family - - - 0.0000000000005699 74.0
TLS2_k127_6805459_0 Catalase K03781 - 1.11.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001172 278.0
TLS2_k127_6811462_0 PFAM ABC transporter related K02056 - 3.6.3.17 6.628e-205 649.0
TLS2_k127_6811462_1 Immunity protein 53 - - - 0.00000000000004093 72.0
TLS2_k127_6811462_2 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000101 70.0
TLS2_k127_682093_0 PrkA AAA domain K07180 - - 3.777e-286 889.0
TLS2_k127_682093_1 PFAM SpoVR like protein K06415 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 595.0
TLS2_k127_682093_2 Belongs to the UPF0229 family K09786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 472.0
TLS2_k127_6824_0 5'-nucleotidase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 466.0
TLS2_k127_6824_1 Flavin containing amine oxidoreductase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 423.0
TLS2_k127_6824_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 301.0
TLS2_k127_6824_3 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 301.0
TLS2_k127_6824_4 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002642 283.0
TLS2_k127_6834113_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 632.0
TLS2_k127_6834113_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004612 337.0
TLS2_k127_6834113_2 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000005049 181.0
TLS2_k127_6834113_3 - - - - 0.00000000000000000001803 97.0
TLS2_k127_6834113_4 FG-GAP repeat - - - 0.000004869 49.0
TLS2_k127_6835939_0 Chlorophyllase enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 469.0
TLS2_k127_6835939_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 334.0
TLS2_k127_6835939_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001901 253.0
TLS2_k127_6835939_3 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007087 264.0
TLS2_k127_6837229_0 Catalyzes the synthesis of activated sulfate K00958 - 2.7.7.4 7.434e-256 800.0
TLS2_k127_6837229_1 aminoglycoside hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 309.0
TLS2_k127_6837229_2 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 295.0
TLS2_k127_6837229_3 Catalyzes the synthesis of activated sulfate K00860,K00955 - 2.7.1.25,2.7.7.4 0.000000000000000000000000000000000000000000000000000000000001535 213.0
TLS2_k127_6837229_4 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000003378 213.0
TLS2_k127_6837229_5 Belongs to the SUA5 family K07566 GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.87 0.0000000000000000000000000000000004852 139.0
TLS2_k127_6837229_6 response regulator - - - 0.0000000000000000000000001234 110.0
TLS2_k127_6837229_7 - - - - 0.000008454 53.0
TLS2_k127_6845727_0 PFAM glycoside hydrolase, family 3 domain protein K05349 - 3.2.1.21 0.0 1052.0
TLS2_k127_6845727_1 Belongs to the glycosyl hydrolase 8 (cellulase D) family K15531 - 3.2.1.156 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006196 525.0
TLS2_k127_6845727_2 PFAM Xylose isomerase domain protein TIM barrel K01805 - 5.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 514.0
TLS2_k127_6845727_3 Bacterial extracellular solute-binding protein K10117 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 517.0
TLS2_k127_6845727_4 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005424 388.0
TLS2_k127_6845727_5 Binding-protein-dependent transport system inner membrane component K02025,K10118,K15771 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005644 317.0
TLS2_k127_6845727_6 Binding-protein-dependent transport system inner membrane component K10119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000286 278.0
TLS2_k127_687256_0 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000006523 140.0
TLS2_k127_687256_1 kinase activity K01006,K01007,K22424 - 2.7.3.13,2.7.9.1,2.7.9.2 0.000000000000000000000001432 111.0
TLS2_k127_687256_2 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000002933 66.0
TLS2_k127_6879435_0 ATPase activity K14338 - 1.14.14.1,1.6.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000001992 271.0
TLS2_k127_6888629_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 339.0
TLS2_k127_6888629_1 Aminomethyltransferase folate-binding domain K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000001283 217.0
TLS2_k127_6888629_2 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000005197 199.0
TLS2_k127_6888629_3 Protein of unknown function (DUF1706) - - - 0.0004985 49.0
TLS2_k127_6889794_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.0 1679.0
TLS2_k127_6889794_1 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000005855 120.0
TLS2_k127_6889794_2 Protein of unknown function (DUF433) - - - 0.000007389 48.0
TLS2_k127_6896418_0 (ABC) transporter K06020 GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 3.6.3.25 1.873e-280 870.0
TLS2_k127_6896418_1 hydrogen-translocating pyrophosphatase activity K01507,K15987 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 516.0
TLS2_k127_6896418_2 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 484.0
TLS2_k127_6896418_3 tRNA synthetase class II core domain (G, H, P, S and T) K01892 - 6.1.1.21 0.000000000000000000000000000000000000000003116 160.0
TLS2_k127_6906460_0 Rhs Family - - - 0.0000000000000000000000000000000000000005032 175.0
TLS2_k127_6906460_1 RHS protein - - - 0.000000001995 74.0
TLS2_k127_6907118_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 377.0
TLS2_k127_6907118_1 Glycosyl transferase, family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008641 310.0
TLS2_k127_6907118_2 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000006728 190.0
TLS2_k127_6907118_3 Acyltransferase family - - - 0.00000005472 64.0
TLS2_k127_6913762_0 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 311.0
TLS2_k127_6913762_1 Fumarylacetoacetate (FAA) hydrolase family K01826 - 5.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008221 291.0
TLS2_k127_6913762_2 Amidohydrolase K07046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 292.0
TLS2_k127_6913762_3 Aldo Keto reductase K17744 - 1.1.1.316 0.000000000000000000000000000000000000000000000000000000000001535 215.0
TLS2_k127_6916468_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006863 495.0
TLS2_k127_6916468_1 PFAM NHL repeat containing protein - - - 0.00000000003322 72.0
TLS2_k127_6916468_2 - - - - 0.0002187 46.0
TLS2_k127_6919486_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000001628 266.0
TLS2_k127_6919486_1 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000002463 242.0
TLS2_k127_6919486_2 NADH dehydrogenase K00337 - 1.6.5.3 0.000000000000000000000001248 105.0
TLS2_k127_6919486_3 Histidine kinase - - - 0.000000000000000009251 91.0
TLS2_k127_6922953_0 carbohydrate binding K00702 - 2.4.1.20 0.0 1140.0
TLS2_k127_6922953_1 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 5.031e-320 1002.0
TLS2_k127_6922953_2 Glycosyltransferase family 36 K00702 - 2.4.1.20 4.293e-210 680.0
TLS2_k127_6922953_3 Glycosyl hydrolases family 16 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 347.0
TLS2_k127_692375_0 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000772 411.0
TLS2_k127_692375_1 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 345.0
TLS2_k127_692804_0 Radical_SAM C-terminal domain K07739 - 2.3.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 504.0
TLS2_k127_692804_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 448.0
TLS2_k127_692804_2 alpha beta - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003313 397.0
TLS2_k127_6937161_0 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000001139 238.0
TLS2_k127_6937161_1 Methyltransferase domain K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000001595 148.0
TLS2_k127_6937161_2 PFAM Haloacid dehalogenase domain protein hydrolase K07025 - - 0.000000000000002559 85.0
TLS2_k127_6937161_3 PFAM response regulator receiver - - - 0.0000004103 60.0
TLS2_k127_6942649_0 ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008866 397.0
TLS2_k127_6942649_1 PFAM Response regulator receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000002012 209.0
TLS2_k127_6942649_2 protein conserved in bacteria containing thioredoxin-like domain - - - 0.00000000000000000000000000000000000000005621 162.0
TLS2_k127_6942649_3 Belongs to the peptidase S26 family K13280 - 3.4.21.89 0.000002563 57.0
TLS2_k127_6942649_4 Helix-hairpin-helix domain - - - 0.00002354 48.0
TLS2_k127_6942649_5 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.00007076 54.0
TLS2_k127_695608_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01464 - 3.5.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 372.0
TLS2_k127_695608_1 Belongs to the P-Pant transferase superfamily K06133 - - 0.000000000000000000000000000000000000000000000000000000000007917 217.0
TLS2_k127_695608_2 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000143 111.0
TLS2_k127_696683_0 Belongs to the ABC transporter superfamily K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 475.0
TLS2_k127_696683_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004699 411.0
TLS2_k127_696683_2 COGs COG0601 ABC-type dipeptide oligopeptide nickel transport systems permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 365.0
TLS2_k127_696683_3 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004278 256.0
TLS2_k127_6970589_0 ADP-glyceromanno-heptose 6-epimerase activity K01709 - 4.2.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 415.0
TLS2_k127_6970589_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 413.0
TLS2_k127_6970589_2 Required for morphogenesis under gluconeogenic growth conditions - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 390.0
TLS2_k127_6970589_3 regulation of single-species biofilm formation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002317 280.0
TLS2_k127_6970589_4 PFAM DUF218 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000504 228.0
TLS2_k127_6970589_5 Nucleotidyl transferase K00978 - 2.7.7.33 0.00000000000000000000000000000000000000000000000000000000000003918 222.0
TLS2_k127_6970589_6 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000001284 174.0
TLS2_k127_6970589_7 oligosaccharyl transferase activity - - - 0.0000000000000001264 91.0
TLS2_k127_6972367_0 FGGY family of carbohydrate kinases, N-terminal domain K00848,K00879,K01813 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008993,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575 2.7.1.5,2.7.1.51,5.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009713 326.0
TLS2_k127_6972367_1 Possible lysine decarboxylase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 304.0
TLS2_k127_6972367_2 helix_turn _helix lactose operon repressor K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000002005 234.0
TLS2_k127_6972367_3 IclR helix-turn-helix domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000001862 220.0
TLS2_k127_6972367_4 FGGY family of carbohydrate kinases, N-terminal domain K00848,K00879,K01813 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008993,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575 2.7.1.5,2.7.1.51,5.3.1.14 0.000000000000000000000000000000000000000000001642 169.0
TLS2_k127_6972367_5 FGGY family of carbohydrate kinases, N-terminal domain K00848 - 2.7.1.5 0.00000000000172 68.0
TLS2_k127_6976339_0 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 529.0
TLS2_k127_6976339_1 hydrolase activity, acting on ester bonds K08680 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016787,GO:0016829,GO:0016835,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0070205,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.2.99.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000001959 271.0
TLS2_k127_6992576_0 peptidase S9B dipeptidylpeptidase IV domain protein K01278 - 3.4.14.5 2.813e-259 813.0
TLS2_k127_6992576_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 1.189e-204 644.0
TLS2_k127_6992576_2 Two component transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 305.0
TLS2_k127_6992576_3 histidine kinase, dimerisation and phosphoacceptor region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005435 255.0
TLS2_k127_6992576_4 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000008041 243.0
TLS2_k127_6992576_5 NapC/NirT cytochrome c family, N-terminal region K15876 - - 0.00000000000000000000000000000000000000000000000000000000002507 208.0
TLS2_k127_7002030_0 Aldehyde dehydrogenase family K04072,K13922 - 1.1.1.1,1.2.1.10,1.2.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 477.0
TLS2_k127_7002030_1 PFAM BMC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 321.0
TLS2_k127_7002030_10 Ethanolamine utilisation protein EutN/carboxysome - - - 0.00000000000000000000004374 102.0
TLS2_k127_7002030_11 Ethanolamine utilisation protein EutN/carboxysome - - - 0.0000000000000000000004512 98.0
TLS2_k127_7002030_12 Ethanolamine utilisation protein EutN/carboxysome - - - 0.0000000000000000533 83.0
TLS2_k127_7002030_13 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000003851 67.0
TLS2_k127_7002030_14 sh3 domain protein K01448,K04771 - 3.4.21.107,3.5.1.28 0.00005466 56.0
TLS2_k127_7002030_15 - - - - 0.0004358 48.0
TLS2_k127_7002030_2 TIGRFAM UbiD family decarboxylase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 306.0
TLS2_k127_7002030_3 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000004324 269.0
TLS2_k127_7002030_4 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.0000000000000000000000000000000000000000000000000000000000006543 222.0
TLS2_k127_7002030_5 galactose-6-phosphate isomerase activity K00761,K01808 - 2.4.2.9,5.3.1.6 0.00000000000000000000000000000000000000000000002042 179.0
TLS2_k127_7002030_6 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000001249 169.0
TLS2_k127_7002030_7 BMC K04027 - - 0.0000000000000000000000000000000000005015 141.0
TLS2_k127_7002030_8 AAA domain K02282 - - 0.0000000000000000000000000000001538 137.0
TLS2_k127_7002030_9 to Propanediol utilization protein PduT of Enterobacteriaceae UniRef RepID B1ER85_9ESCH - - - 0.0000000000000000000000000001574 122.0
TLS2_k127_7003792_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 466.0
TLS2_k127_7003792_1 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002559 283.0
TLS2_k127_7003792_2 hydrolase of the alpha beta-hydrolase fold K07019 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0050526,GO:0052689,GO:0071704 - 0.000000000000000000000000000000000000000000000000000000000000000006898 237.0
TLS2_k127_7003792_3 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000003069 143.0
TLS2_k127_7003792_4 Alpha beta hydrolase - - - 0.0000000000000000000000006303 115.0
TLS2_k127_7006222_0 COG0675 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009151 494.0
TLS2_k127_7006222_1 Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007813 433.0
TLS2_k127_7006222_2 Spermine/spermidine synthase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 355.0
TLS2_k127_7006222_3 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009109 295.0
TLS2_k127_7006222_4 Uncharacterised ACR (DUF711) K09157 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004178 290.0
TLS2_k127_7006222_5 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.00000000000000000000000000000000000000000003496 170.0
TLS2_k127_7006222_6 Transposase K07491 - - 0.00000000000000000000000000000000000000000007068 163.0
TLS2_k127_7006222_7 UbiA prenyltransferase family K03179,K17105 - 2.5.1.39,2.5.1.42 0.0000000000000000000000000000000002294 142.0
TLS2_k127_7006222_8 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.00000000000000000000000006475 107.0
TLS2_k127_7006222_9 sh3 domain protein K01227,K03642 - 3.2.1.96 0.0000000000000000003992 100.0
TLS2_k127_7036291_0 tRNA synthetase, class II (D, K and N) K01893 - 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000006176 205.0
TLS2_k127_7036291_1 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000000000000004978 172.0
TLS2_k127_7036291_2 Transposase IS200 like - - - 0.0000000000000000000000000000000000133 146.0
TLS2_k127_7039732_0 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 561.0
TLS2_k127_7039732_1 HicB family - - - 0.000000000000000000000000000000000000000000000004274 174.0
TLS2_k127_7039732_2 NAD+ synthase (glutamine-hydrolyzing) activity K01916 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 0.00000000000000000008989 91.0
TLS2_k127_7039732_3 - - - - 0.000000000000000001402 91.0
TLS2_k127_7039732_5 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.0009687 42.0
TLS2_k127_7047294_0 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008163 269.0
TLS2_k127_7047294_1 transcriptional regulator domain protein - - - 0.00000000000000000000000000000000003875 143.0
TLS2_k127_7053932_0 Carboxypeptidase Taq (M32) metallopeptidase K01299 - 3.4.17.19 2.059e-218 687.0
TLS2_k127_7053932_1 NB-ARC domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 440.0
TLS2_k127_7053932_2 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 344.0
TLS2_k127_7053932_3 PFAM peptidase S16 lon domain protein K07157 - - 0.0000000000000000000000000000000001137 141.0
TLS2_k127_7053932_4 chromosome segregation - - - 0.00000000000000000000000001944 115.0
TLS2_k127_706963_0 Domain present in carbohydrate binding proteins and sugar hydrolses K07218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 383.0
TLS2_k127_70772_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 1.415e-248 776.0
TLS2_k127_70772_1 nitrite transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 434.0
TLS2_k127_70772_2 PFAM binding-protein-dependent transport systems inner membrane component K02018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 297.0
TLS2_k127_70772_3 Molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009255 275.0
TLS2_k127_70772_4 Belongs to the ABC transporter superfamily K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000002337 270.0
TLS2_k127_7077565_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 2.63e-298 938.0
TLS2_k127_7077565_1 Fumarylacetoacetase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007089 531.0
TLS2_k127_7077565_2 ATPase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007585 373.0
TLS2_k127_7077565_3 enterobactin catabolic process K07214 - - 0.00000000000000000000000000000000000007032 157.0
TLS2_k127_7077565_4 - - - - 0.000000000000000000000000005867 110.0
TLS2_k127_7079931_0 PFAM von Willebrand factor type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000001582 220.0
TLS2_k127_7079931_1 NMT1/THI5 like - - - 0.00000000001737 76.0
TLS2_k127_710492_0 Glycosyltransferase like family 2 K00721,K20534 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 398.0
TLS2_k127_710492_1 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003417 354.0
TLS2_k127_710492_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 350.0
TLS2_k127_710492_3 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000007482 227.0
TLS2_k127_710492_4 HAD superfamily (Subfamily IA) hydrolase, TIGR02254 K01560 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000004727 201.0
TLS2_k127_710492_5 PFAM DSBA-like thioredoxin domain - - - 0.000000000000000000000000006073 119.0
TLS2_k127_710492_6 PFAM CBS domain K04767 - - 0.00000000000000000000005095 103.0
TLS2_k127_710492_7 endonuclease exonuclease phosphatase - - - 0.0000000000000001258 84.0
TLS2_k127_710492_8 VKc - - - 0.00000000461 63.0
TLS2_k127_7109408_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K01782,K07516 - 1.1.1.35,4.2.1.17,5.1.2.3 2.329e-250 796.0
TLS2_k127_7109408_1 Belongs to the thiolase family K00632 - 2.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 522.0
TLS2_k127_7109408_2 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 471.0
TLS2_k127_7109408_3 PFAM acyl-CoA dehydrogenase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 396.0
TLS2_k127_7109408_4 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000003882 129.0
TLS2_k127_7109408_5 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000299 123.0
TLS2_k127_7109408_6 - - - - 0.00001274 51.0
TLS2_k127_7112732_0 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 355.0
TLS2_k127_7112732_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 319.0
TLS2_k127_7115804_0 NUDIX domain K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 373.0
TLS2_k127_7115804_1 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003266 285.0
TLS2_k127_7115804_2 - K19341 - - 0.00000000000000000000000000000000000000000000000000000000000000000001329 242.0
TLS2_k127_7115804_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000003458 214.0
TLS2_k127_7115804_4 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000005747 171.0
TLS2_k127_7115804_5 Cytochrome c K03611 - - 0.00000000000000000000000000000003338 129.0
TLS2_k127_7115804_6 PFAM Cupin 2 conserved barrel domain protein - - - 0.00000000000000000000000000531 113.0
TLS2_k127_7115804_7 lipoprotein involved in nitrous oxide reduction K19342 - - 0.000000000000000000000001207 109.0
TLS2_k127_7115804_9 - - - - 0.000007018 51.0
TLS2_k127_7138654_0 Protein of unknown function DUF86 - - - 0.00000000000000000000000000000000000000000000003341 175.0
TLS2_k127_7138654_1 nucleotidyltransferase activity K00984,K19279 - 2.7.7.47 0.000000000000000000000000000006624 122.0
TLS2_k127_7138654_3 Acetyltransferase (GNAT) domain - - - 0.000000156 60.0
TLS2_k127_7162154_0 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 402.0
TLS2_k127_7162154_1 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 392.0
TLS2_k127_7162154_2 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000591 372.0
TLS2_k127_7162154_3 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003022 256.0
TLS2_k127_7162154_4 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000000001297 161.0
TLS2_k127_7162154_5 ABC-type transport system involved in multi-copper enzyme maturation permease component - - - 0.0000000000000000000000000000000000001191 152.0
TLS2_k127_7162154_6 nuclear chromosome segregation - - - 0.0000000000000000000000000000000006191 149.0
TLS2_k127_7162154_7 NADH pyrophosphatase zinc ribbon domain K03426 - 3.6.1.22 0.0000000000004018 73.0
TLS2_k127_7163592_0 endonuclease I - - - 0.00000000000000000000000000000000000000000000000000000000000002321 225.0
TLS2_k127_7163592_2 BadF/BadG/BcrA/BcrD ATPase family - - - 0.000000000000000000000003659 107.0
TLS2_k127_7220081_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005862 454.0
TLS2_k127_7220081_1 PUCC protein K08226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 342.0
TLS2_k127_7220081_2 ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009204 273.0
TLS2_k127_7220081_3 ABC-type sugar transport system periplasmic component K02027,K05813 - - 0.00000000000000000000000000000000000000000000000000000000000000000001445 252.0
TLS2_k127_7220081_4 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000068 68.0
TLS2_k127_7220081_5 Prolyl oligopeptidase family - - - 0.000007716 58.0
TLS2_k127_7236809_0 Belongs to the glycosyl hydrolase 13 family - - - 0.0 1729.0
TLS2_k127_7236809_1 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000197 176.0
TLS2_k127_7236809_2 - - - - 0.0000126 52.0
TLS2_k127_7240797_0 helix_turn_helix, Lux Regulon K03556 - - 0.0 1055.0
TLS2_k127_7240797_1 NADPH quinone reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004886 349.0
TLS2_k127_7240797_2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003822 267.0
TLS2_k127_7240797_3 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000000000000000000000003594 201.0
TLS2_k127_7240797_5 WD40-like Beta Propeller Repeat - - - 0.00003278 56.0
TLS2_k127_7256690_0 PFAM metal-dependent phosphohydrolase, HD sub domain K01129 - 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004702 443.0
TLS2_k127_7256690_1 - - - - 0.00000000000000000000000000000000000000002941 165.0
TLS2_k127_7256690_2 PFAM TPR repeat-containing protein - - - 0.000000000000000000000000000000115 137.0
TLS2_k127_7259869_0 Ig-like domain from next to BRCA1 gene - GO:0000407,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005776,GO:0006914,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016236,GO:0032182,GO:0043130,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0061919 - 0.0000000000000002408 94.0
TLS2_k127_7272314_0 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 361.0
TLS2_k127_7272314_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 345.0
TLS2_k127_7272314_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002752 275.0
TLS2_k127_7272314_3 regulation of response to stimulus K13730 - - 0.00000000000000000000000000000000000000000000000003546 202.0
TLS2_k127_7272314_4 CAAX protease self-immunity K07052 - - 0.00000000000000000004591 102.0
TLS2_k127_7272314_5 membrane - - - 0.00000000000000003295 93.0
TLS2_k127_7272314_6 - - - - 0.000000000000007316 82.0
TLS2_k127_7272314_7 response to heat K03668,K09914 - - 0.00000000000001415 88.0
TLS2_k127_7272314_8 Polymer-forming cytoskeletal - - - 0.0000001842 62.0
TLS2_k127_7292624_0 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 328.0
TLS2_k127_7292624_1 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000006925 154.0
TLS2_k127_7292624_3 PFAM FHA domain - - - 0.0000004159 63.0
TLS2_k127_7301886_0 ABC transporter C-terminal domain K15738 - - 3.696e-228 722.0
TLS2_k127_7301886_1 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 406.0
TLS2_k127_7301886_10 Heat shock protein DnaJ domain protein - - - 0.0000000008437 69.0
TLS2_k127_7301886_11 metallopeptidase activity - - - 0.000005686 58.0
TLS2_k127_7301886_2 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003219 393.0
TLS2_k127_7301886_3 Belongs to the UPF0758 family K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 298.0
TLS2_k127_7301886_4 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 295.0
TLS2_k127_7301886_5 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009395 263.0
TLS2_k127_7301886_6 carboxylic acid catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000008375 228.0
TLS2_k127_7301886_7 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000002938 207.0
TLS2_k127_7301886_8 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000001343 188.0
TLS2_k127_7301886_9 - - - - 0.0000000000000000001942 96.0
TLS2_k127_7319692_0 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K13668 - 2.4.1.346 1.862e-199 631.0
TLS2_k127_7319692_1 Glycogen debranching enzyme K00696,K07024,K13086 GO:0003674,GO:0003824,GO:0005975,GO:0005984,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034637,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0071704,GO:1901576 2.4.1.14,3.1.3.24,3.1.3.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004071 544.0
TLS2_k127_7319692_2 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000739 250.0
TLS2_k127_7319692_3 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007859 243.0
TLS2_k127_7319692_4 Sucrose-6F-phosphate phosphohydrolase K07024 - 3.1.3.24 0.0000000000000000000000000000000000000000004404 167.0
TLS2_k127_7320732_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009509 367.0
TLS2_k127_7320732_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001017 291.0
TLS2_k127_7320732_2 1-aminocyclopropane-1-carboxylate deaminase K05396 - 4.4.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000001525 258.0
TLS2_k127_7320732_3 helix_turn_helix, Lux Regulon K02479 - - 0.000000000000000000000000000000000000000000001292 172.0
TLS2_k127_7320732_4 Histidine kinase - - - 0.000000000000000000000000000000000001521 158.0
TLS2_k127_7320732_5 Haemolytic - - - 0.0000000000000000000000000000006281 122.0
TLS2_k127_7320732_6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000005251 85.0
TLS2_k127_7320732_7 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000004822 76.0
TLS2_k127_7351146_0 LamG domain protein jellyroll fold domain protein - - - 0.0 1491.0
TLS2_k127_7351146_1 bacterial-type flagellum-dependent cell motility - - - 0.00007607 59.0
TLS2_k127_7357678_0 histidine kinase, dimerisation and phosphoacceptor region K02480 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007385 416.0
TLS2_k127_7357678_1 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 362.0
TLS2_k127_7357678_2 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 0.000000002205 62.0
TLS2_k127_7370520_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 382.0
TLS2_k127_7370520_1 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002752 275.0
TLS2_k127_7370520_2 Lysin motif - - - 0.0000000000000000000000000000000000000000000000000005904 201.0
TLS2_k127_7370520_3 PFAM metal-dependent phosphohydrolase, HD sub domain K07023 - - 0.00000000000000000000000009203 115.0
TLS2_k127_7370520_4 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000004235 94.0
TLS2_k127_7381430_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 2.443e-216 680.0
TLS2_k127_7381430_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.409e-213 676.0
TLS2_k127_7381430_2 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 396.0
TLS2_k127_7381430_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000006589 244.0
TLS2_k127_7381430_4 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.0000000000000000000000000000000000000000000000000000000000000001098 227.0
TLS2_k127_7381430_5 protein with protein kinase and helix-hairpin-helix DNA-binding domains K11130 - - 0.0000000000000000000000000000000000000000003488 178.0
TLS2_k127_7381430_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000106 146.0
TLS2_k127_7381430_7 TIGRFAM Por secretion system C-terminal sorting domain - - - 0.000007689 58.0
TLS2_k127_7397698_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 2.988e-268 833.0
TLS2_k127_7397698_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 3.069e-226 722.0
TLS2_k127_7397698_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000008065 87.0
TLS2_k127_7400262_0 Feruloyl esterase K21105 - 3.1.1.102 0.0000000000000000000000000000000001123 134.0
TLS2_k127_7400262_1 carbohydrate transport K02027,K10117,K11751 - 3.1.3.5,3.6.1.45 0.0000000000000006535 92.0
TLS2_k127_7442797_0 PFAM glycoside hydrolase, family 1 K05350 - 3.2.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 433.0
TLS2_k127_7442797_1 4-vinyl reductase, 4VR - - - 0.000000000002419 70.0
TLS2_k127_7461275_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006521 455.0
TLS2_k127_7461275_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000001971 203.0
TLS2_k127_7461275_2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000003747 176.0
TLS2_k127_7461275_3 metal-binding, possibly nucleic acid-binding protein K07040 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000002136 111.0
TLS2_k127_746296_0 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000001333 186.0
TLS2_k127_746296_1 LysM domain K21449,K22278 - 3.5.1.104 0.000000000000000000001019 110.0
TLS2_k127_74888_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000006425 205.0
TLS2_k127_74888_1 - K01081,K07004 - 3.1.3.5 0.000000000000000000000008946 113.0
TLS2_k127_74888_2 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000002027 63.0
TLS2_k127_753209_0 Berberine and berberine like - - - 1.062e-221 695.0
TLS2_k127_753209_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 608.0
TLS2_k127_753209_2 aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 394.0
TLS2_k127_753209_3 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K00657,K07023 - 2.3.1.57 0.0000000000000000000000000000000000000000000000000001804 190.0
TLS2_k127_753209_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000006071 151.0
TLS2_k127_753209_5 - - - - 0.000000000000000000000000001372 122.0
TLS2_k127_754963_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1503.0
TLS2_k127_754963_1 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 365.0
TLS2_k127_754963_2 PFAM formylmethanofuran dehydrogenase, subunit E region K11261 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000003713 222.0
TLS2_k127_754963_3 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000006902 219.0
TLS2_k127_754963_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.000000000000000000000000000000000000000006214 159.0
TLS2_k127_754963_5 - - - - 0.0000000000000000000000000000005532 125.0
TLS2_k127_754963_6 - - - - 0.000000000000000000009735 98.0
TLS2_k127_754963_7 HNH endonuclease - - - 0.000000007211 60.0
TLS2_k127_75772_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 411.0
TLS2_k127_75772_1 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 339.0
TLS2_k127_75772_2 Esterase PHB depolymerase K03932 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000473 319.0
TLS2_k127_75772_3 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002814 253.0
TLS2_k127_75772_4 COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001405 251.0
TLS2_k127_75772_5 Histidine kinase K07675,K11623 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000002026 204.0
TLS2_k127_75772_6 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000007328 168.0
TLS2_k127_75772_7 Zinc-binding dehydrogenase - - - 0.00000000000000006875 82.0
TLS2_k127_75772_8 Belongs to the Nudix hydrolase family - - - 0.000001351 52.0
TLS2_k127_75772_9 methyltransferase - - - 0.000307 45.0
TLS2_k127_764876_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 556.0
TLS2_k127_764876_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 451.0
TLS2_k127_764876_10 PFAM Transposase - - - 0.00000000008102 63.0
TLS2_k127_764876_2 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 418.0
TLS2_k127_764876_3 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004943 346.0
TLS2_k127_764876_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009212 320.0
TLS2_k127_764876_5 TIGRFAM conserved repeat domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 320.0
TLS2_k127_764876_6 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000002337 188.0
TLS2_k127_764876_7 Ankyrin repeat - - - 0.00000000000000000000000000000002008 143.0
TLS2_k127_764876_8 ThiS family - - - 0.000000000000000000000000003539 113.0
TLS2_k127_764876_9 permease - - - 0.00000000000000000001352 104.0
TLS2_k127_76911_0 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 1.649e-209 661.0
TLS2_k127_76911_1 histidine kinase A domain protein - - - 9.038e-197 661.0
TLS2_k127_76911_2 Membrane - - - 0.00000000000003858 82.0
TLS2_k127_772051_0 Domain of unknown function (DUF4037) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004052 320.0
TLS2_k127_772051_1 Lytic transglycosylase catalytic K08309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005624 327.0
TLS2_k127_772051_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 297.0
TLS2_k127_772051_3 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000005168 250.0
TLS2_k127_772051_4 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000006352 106.0
TLS2_k127_772051_5 - - - - 0.00000000000000004633 92.0
TLS2_k127_772051_6 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000002918 79.0
TLS2_k127_772051_7 - - - - 0.00000000000136 76.0
TLS2_k127_77282_0 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 420.0
TLS2_k127_77282_1 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009059 363.0
TLS2_k127_77282_10 zinc-ribbon domain - - - 0.0000002514 55.0
TLS2_k127_77282_11 WD40 domain protein beta Propeller K03641 - - 0.0000153 57.0
TLS2_k127_77282_2 homocysteine K00547 - 2.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 342.0
TLS2_k127_77282_3 transferase activity, transferring acyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002345 294.0
TLS2_k127_77282_4 Kelch repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000002629 234.0
TLS2_k127_77282_5 PFAM Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000006465 127.0
TLS2_k127_77282_6 Iron permease FTR1 family K07243 - - 0.00000000000009556 85.0
TLS2_k127_77282_7 Ethyl tert-butyl ether degradation - - - 0.0000000001359 66.0
TLS2_k127_77282_8 Protein of unknown function (DUF2877) - - - 0.000000001838 68.0
TLS2_k127_77282_9 Endoribonuclease L-PSP - - - 0.000000005257 60.0
TLS2_k127_77820_0 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032 - - 7.376e-309 960.0
TLS2_k127_77820_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 4.899e-243 762.0
TLS2_k127_77820_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 542.0
TLS2_k127_77820_3 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 388.0
TLS2_k127_77820_4 PIN domain - - - 0.000000000000000000000000000000000002375 142.0
TLS2_k127_77820_5 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.00000000000000000000000000000005238 134.0
TLS2_k127_77820_6 hydrolase activity, hydrolyzing O-glycosyl compounds K00701 - 2.4.1.19 0.000000000000000000000004493 104.0
TLS2_k127_77820_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000002129 64.0
TLS2_k127_77820_8 Methylaspartate ammonia-lyase K04835 - 4.3.1.2 0.0001256 54.0
TLS2_k127_782874_0 peptidase - - - 3.139e-236 744.0
TLS2_k127_782874_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009045 594.0
TLS2_k127_782874_2 TIGRFAM methyltransferase FkbM family - - - 0.00000000000000000008247 101.0
TLS2_k127_785884_0 PFAM extracellular solute-binding protein family 1 K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 474.0
TLS2_k127_785884_1 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002882 271.0
TLS2_k127_785884_2 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000004867 265.0
TLS2_k127_785884_3 glycerophosphodiester transmembrane transport K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000001461 239.0
TLS2_k127_785884_4 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000009924 208.0
TLS2_k127_785884_5 - - - - 0.00000000000000001611 91.0
TLS2_k127_79019_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 561.0
TLS2_k127_79019_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000001273 244.0
TLS2_k127_79019_2 PFAM cyclic nucleotide-binding - - - 0.0000000000000000003933 94.0
TLS2_k127_795419_0 SAICAR synthetase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 388.0
TLS2_k127_795419_1 Putative esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008517 308.0
TLS2_k127_795419_2 PFAM UbiA prenyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 299.0
TLS2_k127_795419_3 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006205 288.0
TLS2_k127_795419_4 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000586 229.0
TLS2_k127_795419_5 PFAM ROK family protein - - - 0.000000003667 59.0
TLS2_k127_797232_0 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 599.0
TLS2_k127_797232_1 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005741 557.0
TLS2_k127_797232_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000006404 209.0
TLS2_k127_801301_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00818 - 2.6.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 392.0
TLS2_k127_801301_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003187 328.0
TLS2_k127_801301_2 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000001362 224.0
TLS2_k127_801301_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000309 153.0
TLS2_k127_808281_0 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005418 466.0
TLS2_k127_81777_0 Helicase conserved C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001777 242.0
TLS2_k127_81777_1 Redoxin domain protein - - - 0.000000000000000000000000000000000000000002611 162.0
TLS2_k127_81777_2 Rieske (2Fe-2S) domain K05710 - - 0.0000000003129 65.0
TLS2_k127_82045_0 Protein of unknown function DUF89 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 338.0
TLS2_k127_82045_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000009691 96.0
TLS2_k127_823518_0 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000005787 259.0
TLS2_k127_823518_1 O-Antigen ligase - - - 0.00000000000000000000000000000000000001411 168.0
TLS2_k127_823518_2 COGs COG3127 ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component K02004 - - 0.00000000000000000126 100.0
TLS2_k127_823518_3 Restriction endonuclease EcoRV - - - 0.00000000008138 63.0
TLS2_k127_823709_0 Penicillin-binding Protein dimerisation domain K03587,K08384 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007564 414.0
TLS2_k127_823709_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 302.0
TLS2_k127_823709_2 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000001099 149.0
TLS2_k127_823709_3 Parallel beta-helix repeats - - - 0.0000000000000000004217 101.0
TLS2_k127_830590_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001543 252.0
TLS2_k127_830590_1 SnoaL-like polyketide cyclase - - - 0.0003476 48.0
TLS2_k127_830590_2 Calx-beta domain - - - 0.0003638 46.0
TLS2_k127_853570_0 PFAM Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000002729 212.0
TLS2_k127_875773_0 metalloendopeptidase activity K08602 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 410.0
TLS2_k127_875773_1 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001798 282.0
TLS2_k127_875773_2 FeoA K03709 - - 0.000000000000000000000000000000000000000000000000001395 190.0
TLS2_k127_875773_3 Membrane - - - 0.0004683 53.0
TLS2_k127_876303_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 1.603e-214 675.0
TLS2_k127_876303_1 PFAM amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 370.0
TLS2_k127_876303_2 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000004978 243.0
TLS2_k127_876303_3 Domain of unknown function (DUF4162) K01990 - - 0.000000000000000000000000000000000000000000000000000002985 203.0
TLS2_k127_876303_4 PFAM restriction endonuclease K07448 - - 0.0001759 53.0
TLS2_k127_876513_0 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002677 273.0
TLS2_k127_876513_1 PFAM Electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000001139 150.0
TLS2_k127_876513_2 Thioredoxin - - - 0.0000000000000000000000000000000000001204 146.0
TLS2_k127_876513_3 Required for disulfide bond formation in some proteins K03611 - - 0.000000000000000000000000000000000002091 142.0
TLS2_k127_876513_4 triphosphatase activity - - - 0.000000000000000000000000000609 119.0
TLS2_k127_879354_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 3.76e-245 764.0
TLS2_k127_879354_1 TIGRFAM dihydroxyacetone kinase, DhaK subunit K00863,K05878 - 2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007698 571.0
TLS2_k127_879354_2 Belongs to the MIP aquaporin (TC 1.A.8) family K02440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007822 327.0
TLS2_k127_879354_3 Dak2 K05879 - 2.7.1.121 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000996 273.0
TLS2_k127_879354_4 PFAM sigma-54 factor interaction domain-containing protein K21405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001523 271.0
TLS2_k127_879354_5 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000004793 190.0
TLS2_k127_879354_6 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000282 98.0
TLS2_k127_879354_7 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase - - - 0.0000000000000000719 94.0
TLS2_k127_879354_8 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000001724 74.0
TLS2_k127_879354_9 SGNH hydrolase-like domain, acetyltransferase AlgX - - - 0.0003244 53.0
TLS2_k127_884706_0 Bacterial PH domain K08981 - - 0.0000000000000000000000000000000002118 151.0
TLS2_k127_884706_1 Protein of unknown function (DUF2723) - - - 0.00000000002214 77.0
TLS2_k127_884706_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000003857 76.0
TLS2_k127_899894_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000002749 169.0
TLS2_k127_899894_1 ferredoxin-NADP+ reductase activity - - - 0.0000000000000000000000000000000004981 141.0
TLS2_k127_899894_2 heat shock protein binding - - - 0.00000000000000000000000000000003058 136.0
TLS2_k127_899894_3 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000001266 112.0
TLS2_k127_899894_4 4Fe-4S binding domain - - - 0.000000000001792 70.0
TLS2_k127_905559_0 peptidase dimerisation domain protein K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008248 486.0
TLS2_k127_905559_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007116 325.0
TLS2_k127_905559_3 4-vinyl reductase, 4VR - - - 0.000000000000000000000000000000000000000002811 163.0
TLS2_k127_905559_4 PFAM adenylate cyclase K05873 - 4.6.1.1 0.000000000000000000000000000000000000001013 155.0
TLS2_k127_907170_0 anaphase-promoting complex binding K07491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 297.0
TLS2_k127_907170_1 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000002225 140.0
TLS2_k127_907170_2 SH3 type 3 domain protein K01447 - 3.5.1.28 0.00003173 55.0
TLS2_k127_913080_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008547 486.0
TLS2_k127_913080_1 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008423 286.0
TLS2_k127_917929_0 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 406.0
TLS2_k127_917929_1 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 334.0
TLS2_k127_917929_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000007206 254.0
TLS2_k127_917929_3 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000001375 204.0
TLS2_k127_917929_4 Thiopurine S-methyltransferase (TPMT) K00569 - 2.1.1.67 0.00000000000000000000000000000000000000002639 160.0
TLS2_k127_917929_5 MarR family - - - 0.0000000000000000000000000000000000000003511 154.0
TLS2_k127_917929_6 - - - - 0.0000000000000000000000000001711 121.0
TLS2_k127_917929_7 Belongs to the GbsR family - - - 0.00000000000008852 78.0
TLS2_k127_91843_0 Carboxyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 478.0
TLS2_k127_91843_1 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.00000000000000000000000000000000000000000000000006302 183.0
TLS2_k127_923348_0 helix_turn_helix, Lux Regulon K03556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006552 460.0
TLS2_k127_923348_1 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000000000000000005843 160.0
TLS2_k127_924035_0 transferase activity, transferring glycosyl groups K21369 - 2.4.1.270 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 421.0
TLS2_k127_924035_1 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 333.0
TLS2_k127_924035_2 PFAM response regulator receiver K11443 - - 0.000000000000000000000000005331 115.0
TLS2_k127_928852_0 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 6.172e-202 636.0
TLS2_k127_928852_1 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005274 357.0
TLS2_k127_934023_0 Protein of unknown function (DUF512) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 347.0
TLS2_k127_934023_1 PFAM aspartate glutamate uridylate kinase K06981 - 2.7.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000483 244.0
TLS2_k127_934023_2 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000695 224.0
TLS2_k127_95346_0 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008179 382.0
TLS2_k127_95346_1 TIGRFAM Phenylacetate-CoA oxygenase, PaaI subunit K02611 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 287.0
TLS2_k127_95346_11 N-acetylmuramoyl-L-alanine amidase K01448 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 0.00006442 54.0
TLS2_k127_95346_2 Protein of unknown function (DUF4012) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005088 277.0
TLS2_k127_95346_3 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K03790 - 2.3.1.128 0.0000000000000000000000000000000000000000000000000132 188.0
TLS2_k127_95346_4 Lamin Tail Domain K07004 - - 0.0000000000000000000000000000000000000000000000001366 198.0
TLS2_k127_95346_5 TIGRFAM phenylacetate-CoA oxygenase, PaaJ subunit K02612 - - 0.00000000000000000000000000000000000000000000003412 176.0
TLS2_k127_95346_6 nucleic acid-binding protein contains PIN domain - - - 0.0000000000000000000000000000000000000002138 154.0
TLS2_k127_95346_7 Belongs to the formate--tetrahydrofolate ligase family K00288,K01938 GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.5.1.5,3.5.4.9,6.3.4.3 0.000000000000000000000000000001984 121.0
TLS2_k127_95346_8 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000001071 81.0
TLS2_k127_957804_0 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 451.0
TLS2_k127_957804_1 integral membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004304 344.0
TLS2_k127_957804_2 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003748 290.0
TLS2_k127_957804_3 Domain of unknown function (DUF5060) - - - 0.0000000000000000000000000000000000000000000000000000000000001008 235.0
TLS2_k127_957804_4 PFAM binding-protein-dependent transport systems inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000005367 196.0
TLS2_k127_957804_5 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.00000000000000000000000000000000001372 139.0
TLS2_k127_959716_0 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 372.0
TLS2_k127_959716_1 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 342.0
TLS2_k127_959716_2 metal-dependent phosphohydrolase, HD sub domain K07037 - - 0.00000000000000000000000000000000000000000000000005859 186.0
TLS2_k127_959716_3 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000000000000000000000000004268 163.0
TLS2_k127_959716_4 PFAM diacylglycerol kinase K00901 - 2.7.1.107 0.000000000000000000000000000000002035 133.0
TLS2_k127_959716_5 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K01489,K03474,K03595,K07042 GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 0.00000000000000000000000000006585 121.0
TLS2_k127_964678_0 domain, Protein - - - 0.000000000000000000000000000000000000000000000124 194.0
TLS2_k127_964678_1 Kelch repeat-containing protein - - - 0.000000000000000000000000000001164 142.0
TLS2_k127_964678_2 Hint (Hedgehog/Intein) domain N-terminal region - - - 0.000000000114 76.0
TLS2_k127_964678_3 PFAM PKD domain - - - 0.00003596 58.0
TLS2_k127_985195_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009137 372.0
TLS2_k127_985195_1 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 - - 0.00000000000000000000000000000000000000000000005654 171.0
TLS2_k127_985195_2 Belongs to the PEP-utilizing enzyme family K01007 - 2.7.9.2 0.000000000000000000000009775 106.0
TLS2_k127_992937_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005581 280.0
TLS2_k127_992937_1 negative regulation of transcription, DNA-templated - - - 0.000000000000000004754 88.0
TLS2_k127_998344_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255,K01259 GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 441.0
TLS2_k127_998344_1 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007386 399.0
TLS2_k127_998344_2 Two component transcriptional regulator, winged helix family K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006279 331.0
TLS2_k127_998344_3 PFAM von Willebrand factor type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003492 271.0
TLS2_k127_998344_4 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000009266 176.0
TLS2_k127_998344_5 histone H2A K63-linked ubiquitination - - - 0.000000000000000000000004167 108.0
TLS2_k127_998344_6 COGs COG2452 site-specific integrase-resolvase - - - 0.00000000000000000003183 93.0
TLS2_k127_998344_7 - - - - 0.00000000000000000006856 91.0