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Overview

ID MAG04008
Name TLS2_bin.47
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Methylomirabilota
Class Methylomirabilia
Order Rokubacteriales
Family CSP1-6
Genus DATKEI01
Species DATKEI01 sp035544455
Assembly information
Completeness (%) 92.21
Contamination (%) 7.99
GC content (%) 72.0
N50 (bp) 5,170
Genome size (bp) 4,398,009

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes4346

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1002222_0 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 385.0
TLS2_k127_1002222_1 protein related to plant photosystem II stability assembly factor - - - 0.00000000000000000000000000000000000000000000000001395 196.0
TLS2_k127_1002222_2 Acetyl-CoA acetyltransferase - - - 0.0000000000000000000000000000005068 126.0
TLS2_k127_1002222_3 Large family of predicted nucleotide-binding domains - - - 0.00000000000000000000001566 105.0
TLS2_k127_1002222_4 - - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.00000000000003071 78.0
TLS2_k127_1011470_0 WYL domain - - - 0.00000000000000000000000000000000000000000000000000000001982 212.0
TLS2_k127_1011470_1 COGs COG2380 conserved - - - 0.000000000000000000000000000000000005339 149.0
TLS2_k127_1011470_2 nucleotidyltransferase activity K07076 - - 0.000000000000000000000000000001509 130.0
TLS2_k127_1011666_0 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 2.802e-198 634.0
TLS2_k127_1011666_1 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001546 283.0
TLS2_k127_1011666_2 TIM-barrel fold metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009167 268.0
TLS2_k127_1011666_3 Protein of unknown function DUF86 - - - 0.000000000000000000000000000000168 129.0
TLS2_k127_1011666_4 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.00000000000000000000000000215 115.0
TLS2_k127_1011666_5 Cytochrome c oxidase caa3-type, assembly factor CtaG-related - - - 0.00000003618 58.0
TLS2_k127_1011666_6 nucleotidyltransferase activity - - - 0.0009687 42.0
TLS2_k127_1012110_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 299.0
TLS2_k127_1012110_1 Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000002322 242.0
TLS2_k127_1012110_2 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000001811 206.0
TLS2_k127_1012110_3 PFAM Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000001356 210.0
TLS2_k127_1012110_4 short-chain dehydrogenase K07535,K10620 - 1.3.1.58 0.00000000000000000000000000000000000000000001011 172.0
TLS2_k127_1013627_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.242e-290 902.0
TLS2_k127_1013627_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 6.489e-266 832.0
TLS2_k127_1013627_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 527.0
TLS2_k127_1013627_3 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 476.0
TLS2_k127_1013627_4 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 458.0
TLS2_k127_1013627_5 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005841 373.0
TLS2_k127_1013627_6 Pyridoxal phosphate biosynthetic protein PdxA K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.0000000000000000000000000000000000000000000000000000000000000000000001398 244.0
TLS2_k127_1013760_0 PFAM FAD linked oxidase domain protein - - - 2.688e-318 1001.0
TLS2_k127_1013760_1 Belongs to the enoyl-CoA hydratase isomerase family K00022,K07514 - 1.1.1.35,4.2.1.17,5.3.3.8 1.286e-270 851.0
TLS2_k127_1013760_10 - - - - 0.00000000000001138 82.0
TLS2_k127_1013760_2 helicase superfamily c-terminal domain K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 3.557e-235 754.0
TLS2_k127_1013760_3 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007601 551.0
TLS2_k127_1013760_4 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004652 376.0
TLS2_k127_1013760_5 NIPSNAP - - - 0.000000000000000000000000000000000000000000000000000000000000000003921 235.0
TLS2_k127_1013760_6 Acetohydroxy acid isomeroreductase, NADPH-binding domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000003601 233.0
TLS2_k127_1013760_7 SNARE associated Golgi protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000007506 168.0
TLS2_k127_1013760_8 Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides K03478 - 3.5.1.105 0.0000000000000000000000000000000000000000002315 173.0
TLS2_k127_1013760_9 - - - - 0.0000000000000000000000000000000002816 139.0
TLS2_k127_1013940_0 Heat shock 70 kDa protein K04043 - - 3.531e-292 909.0
TLS2_k127_1013940_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.588e-277 883.0
TLS2_k127_1013940_2 MazG nucleotide pyrophosphohydrolase domain K02428,K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66,3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 292.0
TLS2_k127_1013940_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003157 282.0
TLS2_k127_1013940_4 PFAM Lytic transglycosylase catalytic K08309 - - 0.000000000000000000000000000000000000000007241 161.0
TLS2_k127_1013940_5 C-terminal domain of histone - - - 0.00000000000000000000000000000000000003091 160.0
TLS2_k127_1013940_6 Transcriptional regulator, MerR family K13640 GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000002218 123.0
TLS2_k127_1013940_7 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000009663 114.0
TLS2_k127_1013940_8 Domain of unknown function (DUF1844) - - - 0.000000000000001603 87.0
TLS2_k127_1016203_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 547.0
TLS2_k127_1016203_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000001839 208.0
TLS2_k127_1016203_2 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000002489 86.0
TLS2_k127_1018533_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 453.0
TLS2_k127_1018533_1 Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily K07536 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 322.0
TLS2_k127_1018533_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001128 251.0
TLS2_k127_1018533_3 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000001005 209.0
TLS2_k127_1018533_4 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000001337 160.0
TLS2_k127_102259_0 Peptidase family M1 domain K08776 - - 2.355e-210 680.0
TLS2_k127_102259_1 KR domain - - - 0.000002501 53.0
TLS2_k127_1024799_0 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 291.0
TLS2_k127_1024799_1 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.00000000000000000000000000000000000000000000000000004193 197.0
TLS2_k127_1024799_2 COG4665 TRAP-type mannitol chloroaromatic compound transport system small permease component - - - 0.00000000000001408 83.0
TLS2_k127_1025017_0 amino acid K03294,K19540 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009788 460.0
TLS2_k127_1025017_1 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000000000000000000002743 221.0
TLS2_k127_1025017_2 Polysaccharide biosynthesis protein K03328 - - 0.000000000000000000000000000000000000000000001016 183.0
TLS2_k127_1031895_0 Thiol disulfide interchange protein K04084,K08344 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006716 389.0
TLS2_k127_1031895_1 Protein of unknown function (DUF3500) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007658 272.0
TLS2_k127_1031895_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000001895 236.0
TLS2_k127_1036576_0 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 435.0
TLS2_k127_1036576_1 Taurine catabolism dioxygenase TauD, TfdA family K22303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 291.0
TLS2_k127_1036576_2 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000006851 271.0
TLS2_k127_1036576_3 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 0.0000000000000000000000000000000000000000000000000000000000001237 216.0
TLS2_k127_1041532_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000001056 241.0
TLS2_k127_1041532_1 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000007672 229.0
TLS2_k127_104414_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K04091 - 1.14.14.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000083 345.0
TLS2_k127_104414_1 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008717 320.0
TLS2_k127_104414_2 PFAM luciferase-like K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000004601 233.0
TLS2_k127_104414_3 Receptor family ligand binding region K01999 - - 0.00000001739 67.0
TLS2_k127_1044720_0 Aconitase C-terminal domain K01681 - 4.2.1.3 0.0 1062.0
TLS2_k127_1044720_1 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009691 599.0
TLS2_k127_1044720_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003912 428.0
TLS2_k127_1044720_3 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 393.0
TLS2_k127_1044720_4 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 349.0
TLS2_k127_1044720_5 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 - 3.5.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 307.0
TLS2_k127_1044720_6 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 302.0
TLS2_k127_1044720_7 subunit beta - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008781 242.0
TLS2_k127_1044720_8 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative mitochondrial subgroup K00239,K00244 - 1.3.5.1,1.3.5.4 0.0000004084 53.0
TLS2_k127_1047653_0 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006947 270.0
TLS2_k127_1047653_1 oxidoreductase activity - - - 0.000000000000000000000000000000000002688 152.0
TLS2_k127_1050923_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 521.0
TLS2_k127_1050923_1 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 426.0
TLS2_k127_1050923_2 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000812 385.0
TLS2_k127_1050923_3 Belongs to the hyi family K01816 - 5.3.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 347.0
TLS2_k127_1050923_4 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 342.0
TLS2_k127_1050923_5 PFAM DoxX family protein K15977 - - 0.0000003307 54.0
TLS2_k127_1053597_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008929 388.0
TLS2_k127_1053597_1 Biotin-lipoyl like K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 308.0
TLS2_k127_1053597_2 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001618 258.0
TLS2_k127_1057657_0 Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 323.0
TLS2_k127_1057657_1 Protein of unknown function (DUF1566) - - - 0.0000000000000000000000000000000000000003032 164.0
TLS2_k127_1060240_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00928,K12524 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 509.0
TLS2_k127_1060240_1 Sigma-70, region 4 K03088 - - 0.00000000000000000000000006828 114.0
TLS2_k127_1060240_2 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases - - - 0.0000000000000000005947 91.0
TLS2_k127_1060240_3 Protein of unknown function (DUF3106) - - - 0.00000000004706 71.0
TLS2_k127_1060240_4 Putative zinc-finger - - - 0.00001009 55.0
TLS2_k127_1060914_0 High confidence in function and specificity - - - 5.77e-287 899.0
TLS2_k127_1060914_1 Domain of unknown function (DUF3459) K01236 - 3.2.1.141 4.387e-259 826.0
TLS2_k127_1060914_2 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000001662 228.0
TLS2_k127_1060914_3 histidine kinase A domain protein - - - 0.00000000000000000000000000477 128.0
TLS2_k127_1060914_4 Protein conserved in bacteria - - - 0.00000837 55.0
TLS2_k127_1061111_0 B12 binding domain - - - 2.618e-217 691.0
TLS2_k127_1061111_1 aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002363 263.0
TLS2_k127_1061111_2 - - - - 0.000000000002801 74.0
TLS2_k127_1061111_3 Domain of Unknown Function (DUF748) - - - 0.000001493 58.0
TLS2_k127_1061111_4 Belongs to the ompA family - - - 0.000002281 53.0
TLS2_k127_106354_0 TOBE domain K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 510.0
TLS2_k127_106354_1 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 477.0
TLS2_k127_106354_2 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006261 480.0
TLS2_k127_106354_3 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 400.0
TLS2_k127_106354_4 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003554 266.0
TLS2_k127_106354_5 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000001497 202.0
TLS2_k127_1065298_0 peptidase dimerisation domain protein K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005078 486.0
TLS2_k127_1065298_1 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 363.0
TLS2_k127_1065298_2 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000007168 244.0
TLS2_k127_1065299_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 1.583e-280 878.0
TLS2_k127_1065299_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008991 295.0
TLS2_k127_1065299_2 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000002901 245.0
TLS2_k127_1068707_0 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 5.234e-250 789.0
TLS2_k127_1068707_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 518.0
TLS2_k127_1068707_2 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000001792 262.0
TLS2_k127_1068707_3 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000001785 133.0
TLS2_k127_1070234_0 Belongs to the transketolase family K00615 - 2.2.1.1 4.28e-298 927.0
TLS2_k127_1070234_1 PFAM Cytochrome c oxidase caa3-type, assembly factor CtaG-related - - - 0.00000000000000000000000000000000000000000000000000000000000000000001561 243.0
TLS2_k127_1074649_0 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003833 260.0
TLS2_k127_1074649_1 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000002986 235.0
TLS2_k127_1074649_2 ABC transporter K01995 - - 0.00000000000000000000000000000000000000001202 161.0
TLS2_k127_1074649_3 Rieske [2Fe-2S] domain - - - 0.000000000000000000001357 102.0
TLS2_k127_1078157_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 364.0
TLS2_k127_1078157_1 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000002622 63.0
TLS2_k127_1080101_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01835 - 5.4.2.2 3.801e-247 774.0
TLS2_k127_1080101_1 acetyltransferase - - - 0.00000000000001212 78.0
TLS2_k127_1080101_2 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.000000001637 60.0
TLS2_k127_1081137_0 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007291 446.0
TLS2_k127_1081137_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001482 243.0
TLS2_k127_1081137_2 PFAM aminotransferase, class I and II - - - 0.000000000000007679 76.0
TLS2_k127_1084879_0 UDP-N-acetylmuramate-L-alanine ligase activity K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008366 554.0
TLS2_k127_1084879_1 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 523.0
TLS2_k127_1084879_10 Cell division protein FtsQ K03589 - - 0.00000000000002181 86.0
TLS2_k127_1084879_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 497.0
TLS2_k127_1084879_3 to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 459.0
TLS2_k127_1084879_4 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003104 436.0
TLS2_k127_1084879_5 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000512 412.0
TLS2_k127_1084879_6 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 393.0
TLS2_k127_1084879_7 Cell cycle protein K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007435 356.0
TLS2_k127_1084879_8 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001567 307.0
TLS2_k127_1084879_9 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000001556 213.0
TLS2_k127_1089226_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 431.0
TLS2_k127_1089226_1 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005249 327.0
TLS2_k127_1089226_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00171,K00172,K19072 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 331.0
TLS2_k127_1089226_3 PFAM Aminotransferase class I and II K05825 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001773 289.0
TLS2_k127_1089226_4 COGs COG1670 Acetyltransferase including N-acetylase of ribosomal protein - - - 0.00000000000000000000000000000000000000000000000000000000000000772 226.0
TLS2_k127_1089226_5 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.000000000000000000000000000000000000000000000000000001461 199.0
TLS2_k127_1089226_6 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00169,K19070 GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.00000000000000000000000000000000000228 156.0
TLS2_k127_1093490_0 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02045,K02049,K02068,K02071,K06857,K10112,K11072 - 3.6.3.25,3.6.3.30,3.6.3.31,3.6.3.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 316.0
TLS2_k127_1093490_1 PFAM Binding-protein-dependent transport system inner membrane component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000004966 231.0
TLS2_k127_1093490_2 Belongs to the ABC transporter superfamily K02017 - 3.6.3.29 0.0000000000000000008224 93.0
TLS2_k127_1093983_0 Aminotransferase K11358 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 472.0
TLS2_k127_1093983_1 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001416 251.0
TLS2_k127_1093983_2 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000007698 182.0
TLS2_k127_1094465_0 Branched-chain amino acid ATP-binding cassette transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004771 556.0
TLS2_k127_1094465_1 COG0657 Esterase lipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000709 359.0
TLS2_k127_1094465_2 Periplasmic binding protein domain K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 352.0
TLS2_k127_1094465_3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004099 276.0
TLS2_k127_1094465_4 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001163 276.0
TLS2_k127_1094465_5 nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003552 274.0
TLS2_k127_1094465_6 Microcin C7 resistance K01297 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009050,GO:0009056,GO:0009254,GO:0009987,GO:0016787,GO:0019538,GO:0030203,GO:0034641,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.4.17.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000006362 266.0
TLS2_k127_1094465_7 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003829 256.0
TLS2_k127_1094465_8 acetyl-coa acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000002555 231.0
TLS2_k127_1096519_0 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007561 413.0
TLS2_k127_1096519_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 0.0000000000000000000000000000000000000000000000000000000000000001641 224.0
TLS2_k127_1096519_2 Single-strand binding protein family K03111 - - 0.0000000000000000000000000000000000000003257 156.0
TLS2_k127_1096519_3 Binds to the 23S rRNA K02939 - - 0.00000000000000000000000000000000001219 140.0
TLS2_k127_1096519_4 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000001846 112.0
TLS2_k127_1096519_5 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000002048 93.0
TLS2_k127_1099026_0 phosphonoacetaldehyde hydrolase activity K01091 - 3.1.3.18 0.00000000000000000000001047 110.0
TLS2_k127_1099026_1 Vitamin K epoxide reductase family - - - 0.000000000000001099 81.0
TLS2_k127_1099026_2 Domain of unknown function (DUF4139) - - - 0.00001034 56.0
TLS2_k127_1101047_0 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 428.0
TLS2_k127_1101047_1 Biotin-lipoyl like K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000001241 243.0
TLS2_k127_1101047_2 TRAP transporter solute receptor, TAXI family K07080 - - 0.00000000000000000000000000000000000000000000000002432 186.0
TLS2_k127_1101047_3 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000163 81.0
TLS2_k127_1101047_4 Domain of unknown function (DUF1850) - - - 0.00000128 60.0
TLS2_k127_1108444_0 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 430.0
TLS2_k127_1108444_1 Bacterial extracellular solute-binding protein K02020 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704 - 0.00000000000000000000000000000000000000000000000000000000000001788 224.0
TLS2_k127_1108444_2 Bacterial extracellular solute-binding protein K05777 - - 0.00000000000000000000000000000000000000000000000000000000004109 225.0
TLS2_k127_1108444_3 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.000000000000000000000000000001106 129.0
TLS2_k127_1108444_4 Amidohydrolase - - - 0.000718 48.0
TLS2_k127_1114789_0 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007688 485.0
TLS2_k127_1114789_1 HpcH/HpaI aldolase/citrate lyase family - - - 0.00000000000000000000000000000000000002959 153.0
TLS2_k127_1118400_0 dUTPase K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 311.0
TLS2_k127_1118400_1 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007644 247.0
TLS2_k127_1118400_2 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000001771 240.0
TLS2_k127_1118400_3 Transcriptional regulator, LysR family - - - 0.00000000000000000000000000000000000000002725 155.0
TLS2_k127_1118400_4 Putative nucleotide-binding of sugar-metabolising enzyme K22129 - 2.7.1.219,2.7.1.220 0.000000000000000000000000000000000000001349 165.0
TLS2_k127_1118400_5 cell redox homeostasis - - - 0.000000000000000000000000000000000312 144.0
TLS2_k127_1118400_6 Pyridoxal phosphate biosynthetic protein PdxA K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000002579 146.0
TLS2_k127_1118400_7 Pup-like protein K13570 - - 0.0000000000000005648 79.0
TLS2_k127_1118400_8 Regulatory protein, FmdB family - - - 0.000000002408 64.0
TLS2_k127_1118890_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000002456 247.0
TLS2_k127_1118890_1 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000001059 165.0
TLS2_k127_1118890_2 YceI-like domain - - - 0.0000000000000000000000000000000000002264 149.0
TLS2_k127_1118890_3 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000001434 85.0
TLS2_k127_1118890_4 - - - - 0.000000000004151 68.0
TLS2_k127_1118890_5 Peptidase, M20 - - - 0.0000000001785 68.0
TLS2_k127_1118890_6 peptidase M20 - - - 0.0000000007284 70.0
TLS2_k127_1120834_0 Ethylbenzene dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 413.0
TLS2_k127_1120834_1 - - - - 0.0000002029 63.0
TLS2_k127_1122950_0 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 381.0
TLS2_k127_1122950_1 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000664 342.0
TLS2_k127_1122950_2 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000003671 208.0
TLS2_k127_1122950_3 Alkylmercury lyase - - - 0.0000000000000000000000000000000006042 136.0
TLS2_k127_1123418_0 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 471.0
TLS2_k127_1123418_1 Hpt domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 381.0
TLS2_k127_1123418_2 ABC transporter substrate binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000001017 243.0
TLS2_k127_1123418_3 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000009304 132.0
TLS2_k127_1125403_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005056 262.0
TLS2_k127_1125403_1 - - - - 0.000000000000000000000000000000000000000000000000001014 198.0
TLS2_k127_1125403_2 - - - - 0.0000004234 61.0
TLS2_k127_1125403_3 - - - - 0.0008042 51.0
TLS2_k127_1134363_0 - - - - 0.0000000000005727 72.0
TLS2_k127_1134363_1 Nodulation protein S (NodS) - - - 0.000001001 61.0
TLS2_k127_1134363_2 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.000002368 58.0
TLS2_k127_1136069_0 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 1.685e-280 877.0
TLS2_k127_1136069_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 538.0
TLS2_k127_1136069_2 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000003687 78.0
TLS2_k127_1136069_3 Cytidylyltransferase K00983,K18431 - 2.7.7.43,2.7.7.82 0.000000000000578 75.0
TLS2_k127_1136069_5 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00009549 48.0
TLS2_k127_1140752_0 Type II/IV secretion system protein K02652,K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 414.0
TLS2_k127_1140752_1 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000003613 142.0
TLS2_k127_1140752_2 HDOD domain - - - 0.0000000000000000000000000000000002556 146.0
TLS2_k127_1140752_3 PFAM acyl-CoA dehydrogenase domain protein K00255,K11731 - 1.3.8.8 0.00000000000000000234 87.0
TLS2_k127_1140752_4 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000001411 78.0
TLS2_k127_1143199_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012,K00066 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.132,1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 563.0
TLS2_k127_1143199_1 GDP-mannose 4,6 dehydratase K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 491.0
TLS2_k127_1143199_2 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 342.0
TLS2_k127_1143199_3 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004635 284.0
TLS2_k127_1143199_4 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000001112 183.0
TLS2_k127_1143199_5 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000002202 135.0
TLS2_k127_1143199_6 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000001573 119.0
TLS2_k127_1143199_7 Trm112p-like protein K09791 - - 0.00000000335 69.0
TLS2_k127_1144051_0 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 469.0
TLS2_k127_1144051_1 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000005291 94.0
TLS2_k127_1150551_0 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 320.0
TLS2_k127_1150551_1 dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000001987 135.0
TLS2_k127_1156062_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 9.664e-212 665.0
TLS2_k127_1156062_1 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.00000000000000000000000000000000000000000000000000000000003393 218.0
TLS2_k127_115860_0 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 424.0
TLS2_k127_115860_1 Belongs to the UbiD family K16874 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 411.0
TLS2_k127_115860_10 integral membrane protein K02221 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000001893 95.0
TLS2_k127_115860_11 DUF167 K09131 - - 0.0000000000005915 75.0
TLS2_k127_115860_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 374.0
TLS2_k127_115860_3 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002008 290.0
TLS2_k127_115860_4 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000001414 249.0
TLS2_k127_115860_5 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000001009 219.0
TLS2_k127_115860_6 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0005488,GO:0005507,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.00000000000000000000000000000000000001307 153.0
TLS2_k127_115860_7 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.0000000000000000000000000000000007938 152.0
TLS2_k127_115860_8 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000002215 118.0
TLS2_k127_115860_9 PFAM DivIVA family protein K04074 - - 0.00000000000000000000002782 105.0
TLS2_k127_1160899_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 456.0
TLS2_k127_1160899_1 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.0000000000000000002436 90.0
TLS2_k127_1167216_0 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008489 265.0
TLS2_k127_1167216_1 ATP dependent DNA ligase domain protein K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000002429 214.0
TLS2_k127_1182626_0 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000003568 226.0
TLS2_k127_1182626_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000005815 162.0
TLS2_k127_1192273_0 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000000000000000000000001451 182.0
TLS2_k127_1194369_0 COG3119 Arylsulfatase A and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 417.0
TLS2_k127_1194369_1 Luciferase-like monooxygenase K20938 - 1.14.14.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006923 328.0
TLS2_k127_1194369_2 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01872,K07050 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000006954 212.0
TLS2_k127_1194369_3 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000001958 188.0
TLS2_k127_1195976_0 VanZ like family - - - 0.00000000000000000000000000000000000000003077 167.0
TLS2_k127_1195976_1 Fumarylacetoacetate (FAA) hydrolase family K01617,K02554 - 4.1.1.77,4.2.1.80 0.00000000000000000000000000000000000000009208 157.0
TLS2_k127_1198319_0 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007794 308.0
TLS2_k127_1198319_1 Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit K03821 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003799 305.0
TLS2_k127_1198319_10 polyhydroxyalkanoic acid synthase, PhaR subunit - - - 0.0000000025 70.0
TLS2_k127_1198319_2 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000001109 278.0
TLS2_k127_1198319_3 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000006399 241.0
TLS2_k127_1198319_4 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000009854 235.0
TLS2_k127_1198319_5 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000002736 220.0
TLS2_k127_1198319_6 PFAM regulatory protein TetR K13770 - - 0.00000000000000000000000000000000000000000001258 169.0
TLS2_k127_1198319_7 MaoC like domain K17865 - 4.2.1.55 0.0000000000000000000000000000000000000002032 157.0
TLS2_k127_1198319_8 PFAM PHA accumulation regulator DNA-binding protein - - - 0.0000000000000000000000000586 113.0
TLS2_k127_1198319_9 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000006034 100.0
TLS2_k127_1203857_0 Major Facilitator Superfamily K19577 - - 0.00000000000000000006806 103.0
TLS2_k127_1203857_1 Bacterial antitoxin of type II TA system, VapB - - - 0.0004604 43.0
TLS2_k127_1208185_0 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006159 535.0
TLS2_k127_1208185_1 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004853 327.0
TLS2_k127_1208185_2 - - - - 0.00000000000000000001739 107.0
TLS2_k127_1208185_3 Nitroreductase family K21375 - 1.3.3.13 0.00000000000000006905 89.0
TLS2_k127_1208379_0 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000191 259.0
TLS2_k127_1208379_1 PFAM acyl-CoA dehydrogenase domain protein - - - 0.00000000000000000001639 107.0
TLS2_k127_1209022_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 1.808e-233 735.0
TLS2_k127_1209022_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 412.0
TLS2_k127_1209022_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 397.0
TLS2_k127_1209022_3 Belongs to the KdsA family K01627 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008676,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016043,GO:0016051,GO:0016053,GO:0016740,GO:0016765,GO:0019294,GO:0019752,GO:0022607,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 358.0
TLS2_k127_1209022_4 Tyrosine recombinase XerD K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001055 271.0
TLS2_k127_1209022_5 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000001249 203.0
TLS2_k127_1209022_6 Neutral/alkaline non-lysosomal ceramidase, N-terminal - - - 0.00000000000000000000000001576 126.0
TLS2_k127_1209022_7 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.00000000006261 71.0
TLS2_k127_1209022_8 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.000000002615 70.0
TLS2_k127_1209022_9 Lipopolysaccharide-assembly - - - 0.000001136 61.0
TLS2_k127_1215100_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000588 389.0
TLS2_k127_1215100_1 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000009665 229.0
TLS2_k127_1216087_0 Phage late control gene D protein (GPD) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 424.0
TLS2_k127_1216087_1 PFAM Peptidoglycan-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009688 282.0
TLS2_k127_1216087_2 Gene 25-like lysozyme K06903 - - 0.000000000000000000000000000000000000003286 154.0
TLS2_k127_1216087_3 Rhs element vgr protein - - - 0.000000000000000000000000000000000000004804 166.0
TLS2_k127_1216087_4 - - - - 0.00000000000000000000000000000000000003468 147.0
TLS2_k127_1216087_5 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000732 134.0
TLS2_k127_1216087_6 PAAR repeat-containing protein - - - 0.0000000000000000000004873 107.0
TLS2_k127_1216087_7 - - - - 0.0000000000000025 83.0
TLS2_k127_1216087_8 Baseplate J-like protein - - - 0.000007154 56.0
TLS2_k127_1216313_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 299.0
TLS2_k127_1216313_1 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005998 279.0
TLS2_k127_1216313_2 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000004169 136.0
TLS2_k127_1219205_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 465.0
TLS2_k127_1219205_1 Adenine deaminase C-terminal domain K01486 - 3.5.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006374 457.0
TLS2_k127_1219205_10 pilus assembly protein PilW - - - 0.0000001223 60.0
TLS2_k127_1219205_11 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005507,GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044421,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 0.00001155 48.0
TLS2_k127_1219205_2 cytochrome C peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006782 419.0
TLS2_k127_1219205_3 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 364.0
TLS2_k127_1219205_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 353.0
TLS2_k127_1219205_5 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 345.0
TLS2_k127_1219205_6 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 340.0
TLS2_k127_1219205_7 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 307.0
TLS2_k127_1219205_8 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000002259 249.0
TLS2_k127_1219205_9 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.0000000000000000000000000000007746 127.0
TLS2_k127_1222571_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652,K03852 - 2.2.1.6,2.3.3.15 2.964e-254 795.0
TLS2_k127_1222571_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 519.0
TLS2_k127_1222571_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001392 282.0
TLS2_k127_1222571_3 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K06034 - 4.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008205 268.0
TLS2_k127_1222571_4 ThiJ PfpI - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001766 265.0
TLS2_k127_1222571_5 Serine Threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000003631 186.0
TLS2_k127_1222571_6 ABC transporter K02003 - - 0.000000000000000001956 87.0
TLS2_k127_1223693_0 PFAM ABC transporter K02471 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 623.0
TLS2_k127_1223693_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 287.0
TLS2_k127_1223693_2 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000009431 253.0
TLS2_k127_1233074_0 UPF0365 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 499.0
TLS2_k127_1233074_1 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 471.0
TLS2_k127_1233074_2 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000002149 203.0
TLS2_k127_1233074_3 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000117 79.0
TLS2_k127_1237146_0 Glutamate synthase central domain K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1052.0
TLS2_k127_1237146_1 COG0583 Transcriptional regulator - - - 0.00000000000000000000000001139 113.0
TLS2_k127_1242113_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000435 301.0
TLS2_k127_1242113_1 SMP-30 Gluconolaconase LRE domain protein K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005743 281.0
TLS2_k127_1242113_2 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000129 153.0
TLS2_k127_1242113_3 Protein of unknown function (DUF2652) - - - 0.00000000000000000000000000004274 122.0
TLS2_k127_1242113_4 non-haem dioxygenase in morphine synthesis N-terminal - - - 0.00000000000000000002416 93.0
TLS2_k127_124372_0 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 362.0
TLS2_k127_124372_1 SMART AAA ATPase K02450 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004086 257.0
TLS2_k127_124372_2 Lipopolysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000001335 196.0
TLS2_k127_124372_3 alginic acid biosynthetic process - - - 0.0000000000000000000000000000000000000004836 162.0
TLS2_k127_124372_4 Capsular exopolysaccharide family K08252 - 2.7.10.1 0.000000000000000000000000001644 130.0
TLS2_k127_124502_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 3.277e-299 932.0
TLS2_k127_124502_1 Belongs to the transketolase family K00163 - 1.2.4.1 5.163e-233 743.0
TLS2_k127_124502_2 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain K01596,K01610 - 4.1.1.32,4.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 511.0
TLS2_k127_124502_3 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000003381 173.0
TLS2_k127_124502_4 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000247 129.0
TLS2_k127_1251469_0 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000753 598.0
TLS2_k127_1251469_1 Amidohydrolase family K01464 - 3.5.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 420.0
TLS2_k127_1251469_2 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001726 291.0
TLS2_k127_1251469_3 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000001998 210.0
TLS2_k127_1251469_4 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000004483 213.0
TLS2_k127_1251469_5 Toxic component of a toxin-antitoxin (TA) module. An RNase - GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113 - 0.00000000000000000000001091 100.0
TLS2_k127_1259017_0 regulation of DNA-templated transcription, elongation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005281 449.0
TLS2_k127_1259017_1 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000001209 194.0
TLS2_k127_1259017_2 Domain of unknown function (DUF4410) - - - 0.000000000000000000000000000000009289 143.0
TLS2_k127_1259017_3 [2Fe-2S] binding domain K03518,K13483 - 1.2.5.3 0.0000001389 53.0
TLS2_k127_1259017_4 efflux transmembrane transporter activity - - - 0.0009424 46.0
TLS2_k127_1259041_0 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000502 256.0
TLS2_k127_1259041_1 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000002411 233.0
TLS2_k127_1259041_2 Gluconolactonase K01053,K14274 - 3.1.1.17 0.0000000000000000000000000000000006081 140.0
TLS2_k127_1259041_3 Tautomerase enzyme K01821 - 5.3.2.6 0.00000000000003796 75.0
TLS2_k127_1264873_0 cation diffusion facilitator family transporter K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 312.0
TLS2_k127_1264873_1 Class ii aldolase K01628,K03077 - 4.1.2.17,5.1.3.4 0.00000000000000000000000000000000000000000000000000002611 193.0
TLS2_k127_1265713_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 3.038e-260 809.0
TLS2_k127_1265713_1 TIGRFAM drug resistance transporter, EmrB QacA subfamily K03446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 480.0
TLS2_k127_1268435_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009463 593.0
TLS2_k127_1268435_1 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 509.0
TLS2_k127_1268435_10 - - - - 0.000000001107 65.0
TLS2_k127_1268435_11 PFAM glycosyl transferase family 39 - - - 0.0000003198 57.0
TLS2_k127_1268435_12 - - - - 0.0000008507 59.0
TLS2_k127_1268435_2 DegT/DnrJ/EryC1/StrS aminotransferase family K04127 - 5.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 492.0
TLS2_k127_1268435_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004639 458.0
TLS2_k127_1268435_4 Belongs to the FGGY kinase family K00851 - 2.7.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006159 407.0
TLS2_k127_1268435_5 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 390.0
TLS2_k127_1268435_6 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000001836 254.0
TLS2_k127_1268435_7 PFAM mannose-6-phosphate isomerase K01809 - 5.3.1.8 0.00000000000000000000000000000000000007923 153.0
TLS2_k127_1268435_8 ribose 5-phosphate isomerase B K01808 - 5.3.1.6 0.000000000000000000000000000000002756 151.0
TLS2_k127_1268435_9 Peptidase family M48 - - - 0.0000000000000002334 92.0
TLS2_k127_1276914_0 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 2.482e-264 828.0
TLS2_k127_1276914_1 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009393 423.0
TLS2_k127_1276914_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001438 286.0
TLS2_k127_1276914_3 Iron-containing redox enzyme K06137 - 1.3.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000002393 244.0
TLS2_k127_1276914_4 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000000000000000001172 198.0
TLS2_k127_1276914_5 (Rieske (2Fe-2S) domain) K00363,K05710 - 1.7.1.15 0.00000000000000000000004846 102.0
TLS2_k127_1276914_6 Haem-degrading - - - 0.0000000000000000000001675 99.0
TLS2_k127_1276914_7 PFAM EamA-like transporter family - - - 0.0000000000000000002719 99.0
TLS2_k127_1282265_0 Putative modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 588.0
TLS2_k127_1282265_1 metallopeptidase activity K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 524.0
TLS2_k127_1282265_10 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.000000000002147 69.0
TLS2_k127_1282265_11 Domain of unknown function (DUF309) K09763 - - 0.000005603 58.0
TLS2_k127_1282265_12 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00005906 52.0
TLS2_k127_1282265_2 molybdopterin K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 361.0
TLS2_k127_1282265_3 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 342.0
TLS2_k127_1282265_4 PFAM Transketolase, C-terminal domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003525 299.0
TLS2_k127_1282265_5 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000134 282.0
TLS2_k127_1282265_6 domain protein K01992,K06994 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007357 263.0
TLS2_k127_1282265_7 Radical SAM - - - 0.00000000000000000000000000002885 125.0
TLS2_k127_1282265_8 RNA recognition motif - - - 0.0000000000000000000000001636 111.0
TLS2_k127_1282265_9 RDD family - - - 0.0000000000001843 78.0
TLS2_k127_1296821_0 N-methylhydantoinase A acetone carboxylase, beta subunit - - - 1.613e-199 654.0
TLS2_k127_1296821_1 Protein of unknown function (DUF917) K09703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 509.0
TLS2_k127_1296821_2 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02054 - - 0.0000000000000000000000000000000000000000000000000000000000000000001918 239.0
TLS2_k127_1296821_3 Binding-protein-dependent transport system inner membrane component K02053 - - 0.000000000000000000000000000000000000000000000000000000002258 222.0
TLS2_k127_1296821_4 PIN domain - - - 0.000000000000000000000000000000000001895 144.0
TLS2_k127_1296821_5 AroM protein K14591 - - 0.000000003026 61.0
TLS2_k127_131528_0 Retinal pigment epithelial membrane protein K11159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007001 273.0
TLS2_k127_131528_1 DEAD DEAH box K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004803 257.0
TLS2_k127_132239_0 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 445.0
TLS2_k127_132239_1 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009649 372.0
TLS2_k127_132239_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007157 284.0
TLS2_k127_132239_3 ABC-type dipeptide oligopeptide nickel transport K02034,K15582 - - 0.00000000000000000000000000000000000000000000000000000000000000002239 248.0
TLS2_k127_132239_4 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000004253 160.0
TLS2_k127_132239_5 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 0.00000000000000000000000006859 118.0
TLS2_k127_132239_6 polygalacturonase activity K01184 - 3.2.1.15 0.000000000000000000003037 104.0
TLS2_k127_132239_7 Luciferase-like monooxygenase - - - 0.00000000000002145 76.0
TLS2_k127_132239_8 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0001453 53.0
TLS2_k127_1327372_0 Hydantoinaseoxoprolinase domain protein K01469,K01473 - 3.5.2.14,3.5.2.9 1.154e-220 701.0
TLS2_k127_1327372_1 TRAP transporter solute receptor, TAXI family K07080 - - 0.00000000000000000000000000000004241 131.0
TLS2_k127_1328759_0 Proton-conducting membrane transporter K12137,K15828 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 612.0
TLS2_k127_1328759_1 Proton-conducting membrane transporter K12141 GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 447.0
TLS2_k127_1328759_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 363.0
TLS2_k127_1328759_3 NADH dehydrogenase K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007857 384.0
TLS2_k127_1328759_4 NADH dehydrogenase (ubiquinone) activity K14089 - - 0.00000000000000000000000000000000000000000000000000000000001067 215.0
TLS2_k127_1328759_5 oxidoreductase - - - 0.000000000000000000000000000000000000000004424 166.0
TLS2_k127_1328759_6 Hydrogenase 4 membrane K12140 GO:0008150,GO:0040007 - 0.000000000000000000000000000000002222 147.0
TLS2_k127_1328759_7 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000005369 131.0
TLS2_k127_1328759_8 KR domain - - - 0.000000000000000000003398 97.0
TLS2_k127_1332785_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 1.863e-208 661.0
TLS2_k127_1332785_1 L-carnitine dehydratase bile acid-inducible protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 511.0
TLS2_k127_1332785_2 thioesterase K07107 - - 0.0000000000000000000000008197 113.0
TLS2_k127_1332785_3 PFAM ABC transporter related K01990 - - 0.0001193 46.0
TLS2_k127_1336008_0 EcsC protein family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009843 267.0
TLS2_k127_1336008_1 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000002435 217.0
TLS2_k127_1336008_2 Endoribonuclease L-PSP - - - 0.0000000000000000003915 96.0
TLS2_k127_1337745_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 4.539e-259 823.0
TLS2_k127_1337745_1 Short-chain dehydrogenase reductase sdr K00059,K03366 - 1.1.1.100,1.1.1.304,1.1.1.76 0.000000000000000000000000000000000000000000000000000005753 203.0
TLS2_k127_1337745_2 Protein of unknown function, DUF - - - 0.0000000000000000000000000000000000000000000025 168.0
TLS2_k127_1337745_3 Amidohydrolase - - - 0.0000000000000000000000000000000000002399 141.0
TLS2_k127_1337745_4 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.000000000000000000002937 108.0
TLS2_k127_1340512_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 7.998e-211 678.0
TLS2_k127_1340512_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000005285 209.0
TLS2_k127_1340529_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 7.998e-211 678.0
TLS2_k127_1340529_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000428 212.0
TLS2_k127_135037_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K11177 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 474.0
TLS2_k127_135037_1 PFAM TPR repeat-containing protein - - - 0.0000000000000000000000003329 111.0
TLS2_k127_135037_2 ThiS family K03636 - - 0.00000000000000003491 87.0
TLS2_k127_1353400_0 Inositol monophosphatase family K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000003722 211.0
TLS2_k127_1353400_1 PFAM zinc iron permease K07238 - - 0.0000000000000000000000000000000000000000000000000000006151 211.0
TLS2_k127_1353400_2 methyltransferase - - - 0.0000000000000000000000000000000000001095 154.0
TLS2_k127_1353400_3 Amidohydrolase family - - - 0.000000000000000005968 85.0
TLS2_k127_1353400_4 TIGRFAM Protein of - - - 0.0000000000005289 72.0
TLS2_k127_1353400_5 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000002929 60.0
TLS2_k127_1355579_0 COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007332 417.0
TLS2_k127_1355579_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 398.0
TLS2_k127_1355579_2 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 387.0
TLS2_k127_1355579_3 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000000000005596 131.0
TLS2_k127_1358764_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 612.0
TLS2_k127_1358764_1 Histidine Phosphotransfer domain - - - 0.00000000002128 65.0
TLS2_k127_1358764_2 4-hydroxyphenylacetate 3-hydroxylase C terminal K00483 - 1.14.14.9 0.000003549 49.0
TLS2_k127_136189_0 PFAM Formylglycine-generating sulfatase enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008464 533.0
TLS2_k127_136189_1 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006673 371.0
TLS2_k127_136189_2 Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine K18911 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008213,GO:0008276,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0019439,GO:0019538,GO:0019752,GO:0032259,GO:0034641,GO:0036211,GO:0042398,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052707,GO:0052708,GO:0052709,GO:0052803,GO:0052805,GO:0071704,GO:0071944,GO:0097164,GO:0140096,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000001002 278.0
TLS2_k127_136189_3 - - - - 0.00000000000000000000000004133 108.0
TLS2_k127_1383200_0 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004 267.0
TLS2_k127_1383200_1 Enoyl-(Acyl carrier protein) reductase K00059,K18009,K19548 - 1.1.1.100,1.1.1.304,1.1.1.385,1.1.1.76 0.00000000000000000000000000000000000000000000000002335 190.0
TLS2_k127_1383200_2 Domain of unknown function (DUF4203) - - - 0.0000000000000001787 87.0
TLS2_k127_1383200_3 Methyltransferase type 11 - - - 0.00001949 49.0
TLS2_k127_1390514_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006309 385.0
TLS2_k127_1390514_1 Carboxylesterase family K03929 - - 0.000000000000000000000000000000000000000008075 162.0
TLS2_k127_1390514_2 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000004429 102.0
TLS2_k127_1390783_0 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003946 329.0
TLS2_k127_1390783_1 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 301.0
TLS2_k127_1390783_2 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 317.0
TLS2_k127_1390783_3 Family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000002749 214.0
TLS2_k127_1390783_4 MFS_1 like family - - - 0.000000000000000000024 105.0
TLS2_k127_1391229_0 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002084 258.0
TLS2_k127_1391229_1 COG0559 Branched-chain amino acid ABC-type transport system, permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007913 258.0
TLS2_k127_1391229_2 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001625 260.0
TLS2_k127_1391229_3 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000007115 261.0
TLS2_k127_1391229_4 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000001198 241.0
TLS2_k127_140961_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007425 466.0
TLS2_k127_140961_1 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008252 331.0
TLS2_k127_140961_2 KR domain K00059,K21883 - 1.1.1.100,1.1.1.401 0.0000000000000000000000000000000000000000000000000000000000000000000000001089 256.0
TLS2_k127_140961_3 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.00000000000000000000000000000000000000002076 176.0
TLS2_k127_1417931_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 473.0
TLS2_k127_1417931_1 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 372.0
TLS2_k127_1417931_2 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000003206 166.0
TLS2_k127_1422427_0 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 1.166e-194 639.0
TLS2_k127_1422427_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 615.0
TLS2_k127_1422427_10 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000005269 61.0
TLS2_k127_1422427_11 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000006227 64.0
TLS2_k127_1422427_2 Endoribonuclease that initiates mRNA decay K05802,K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 522.0
TLS2_k127_1422427_3 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 455.0
TLS2_k127_1422427_4 Aminoacyl tRNA synthetase class II, N-terminal domain K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 426.0
TLS2_k127_1422427_5 PFAM Metallophosphoesterase K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 325.0
TLS2_k127_1422427_6 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.000000000000000000000000000000000000000000000000000000003719 203.0
TLS2_k127_1422427_7 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000001802 141.0
TLS2_k127_1422427_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K03832 - - 0.0000000000001021 83.0
TLS2_k127_1422427_9 PFAM SNARE associated Golgi protein - - - 0.0000000008766 63.0
TLS2_k127_142464_0 protease-associated PA domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005975 460.0
TLS2_k127_142464_1 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.000000000000000000000000000000000000000000002519 188.0
TLS2_k127_142464_2 Ketopantoate reductase PanE/ApbA C terminal - - - 0.0000000000000000000000008372 108.0
TLS2_k127_142662_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain K03520,K11177 - 1.17.1.4,1.2.5.3 1.666e-219 705.0
TLS2_k127_142662_1 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K03921,K20087 - 1.14.19.11,1.14.19.2,1.14.19.26,1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006377 291.0
TLS2_k127_142662_2 Fatty acid desaturase - - - 0.00000007239 62.0
TLS2_k127_142926_0 Gamma-glutamyltranspeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 374.0
TLS2_k127_142926_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002332 268.0
TLS2_k127_142926_2 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000001067 240.0
TLS2_k127_142926_3 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000495 237.0
TLS2_k127_142926_4 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000006514 200.0
TLS2_k127_142926_5 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000003474 190.0
TLS2_k127_142926_6 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000002165 177.0
TLS2_k127_142926_7 - - - - 0.00000000004715 71.0
TLS2_k127_142926_8 ChrR Cupin-like domain - - - 0.0003061 43.0
TLS2_k127_1440120_0 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 521.0
TLS2_k127_1440120_1 Penicillin-binding protein 2 K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 478.0
TLS2_k127_1440120_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 303.0
TLS2_k127_1440120_3 Metal-sensitive transcriptional repressor K21600 - - 0.0000000000000000000000403 104.0
TLS2_k127_1440120_4 Involved in formation and maintenance of cell shape K03570 - - 0.000000002213 61.0
TLS2_k127_1440120_5 rod shape-determining protein (MreD) K03571 - - 0.0000000172 64.0
TLS2_k127_1444323_0 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000003577 214.0
TLS2_k127_1444323_1 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000003949 139.0
TLS2_k127_1444323_2 Histidine kinase A domain protein - - - 0.00000000000001812 85.0
TLS2_k127_1447109_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006051 617.0
TLS2_k127_1447109_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 471.0
TLS2_k127_1447109_2 Alcohol dehydrogenase GroES domain protein - - - 0.000000000000000003311 91.0
TLS2_k127_1447109_3 Fungal family of unknown function (DUF1776) - - - 0.00000000001078 73.0
TLS2_k127_1452488_0 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 386.0
TLS2_k127_1452488_1 Transcription elongation factor, N-terminal K03624 - - 0.00000000000000000000000000000000000000002849 161.0
TLS2_k127_1460667_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 400.0
TLS2_k127_1460667_1 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 291.0
TLS2_k127_1460667_3 Bacterial protein of unknown function (DUF899) - - - 0.0000000000000000000000000000000007219 141.0
TLS2_k127_1460667_4 Serine aminopeptidase, S33 - - - 0.00000000000000000000000001052 112.0
TLS2_k127_1482166_0 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 428.0
TLS2_k127_1482166_1 Cytochrome c biogenesis protein K06196 - - 0.000000000004889 73.0
TLS2_k127_1482166_2 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000004588 55.0
TLS2_k127_14952_0 Belongs to the TtcA family K21947 - 2.8.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001401 275.0
TLS2_k127_14952_1 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000009975 249.0
TLS2_k127_14952_2 Aldo/keto reductase family - - - 0.000000000000000004218 84.0
TLS2_k127_14952_3 thiamine diphosphate biosynthetic process K03154 - - 0.000000000009969 71.0
TLS2_k127_14952_4 DinB superfamily - - - 0.0000000231 64.0
TLS2_k127_1501019_0 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.00000000000000000000000000000000000000000000002613 191.0
TLS2_k127_1501019_1 Poly A polymerase head domain K00970,K00974,K07276,K19545 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000001052 169.0
TLS2_k127_1501019_2 Pfam:KaiC - - - 0.0000000000000000000000000004175 119.0
TLS2_k127_1501019_3 Winged helix DNA-binding domain - - - 0.0000006544 61.0
TLS2_k127_15066_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 574.0
TLS2_k127_15066_1 biosynthesis protein E K06139 GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004303 501.0
TLS2_k127_15066_2 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 376.0
TLS2_k127_15066_3 May be involved in the transport of PQQ or its precursor to the periplasm K06136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 366.0
TLS2_k127_15066_4 Histidine phosphatase superfamily (branch 1) - - - 0.000000000000000000000000000009808 135.0
TLS2_k127_15110_0 Gamma-glutamyltranspeptidase K00681 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 363.0
TLS2_k127_15110_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000005561 196.0
TLS2_k127_15110_2 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000007376 189.0
TLS2_k127_15110_3 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000001189 141.0
TLS2_k127_15110_4 Domain of unknown function (DUF4397) - - - 0.00000000000000000000000002117 117.0
TLS2_k127_15110_5 Esterase of the alpha-beta hydrolase superfamily - - - 0.0000000001521 70.0
TLS2_k127_152433_0 Peptidoglycan-binding domain 1 protein K02450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000001501 259.0
TLS2_k127_152433_1 Secretin and TonB N terminus short domain K02666 - - 0.0000000000000000000000000000000000000000000002075 186.0
TLS2_k127_1537767_0 Alpha amylase, catalytic domain - - - 2.321e-197 632.0
TLS2_k127_1537767_1 acetyltransferase - - - 0.00000000000266 76.0
TLS2_k127_1537767_2 Voltage gated chloride channel K03281 - - 0.00000000002448 68.0
TLS2_k127_1539459_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781,K20023 - 4.2.1.156,4.2.1.42,5.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 446.0
TLS2_k127_1539459_1 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.000000000000004312 79.0
TLS2_k127_1539459_2 Luciferase-like monooxygenase - - - 0.0003084 50.0
TLS2_k127_1547221_0 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 455.0
TLS2_k127_1547221_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000742 260.0
TLS2_k127_1547221_2 Belongs to the glycosyltransferase 26 family - - - 0.0000000000000000000000000000000004095 148.0
TLS2_k127_155408_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 6.696e-253 790.0
TLS2_k127_155408_1 Monogalactosyldiacylglycerol (MGDG) synthase K03429 - 2.4.1.315 0.000000000000000000000000000000000000000000000000000000000004638 227.0
TLS2_k127_155408_2 MaoC like domain - - - 0.0000000000000000000000000000000000008689 147.0
TLS2_k127_155408_3 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000001445 152.0
TLS2_k127_155408_4 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.000000000000000000503 89.0
TLS2_k127_155408_5 dehydratase - - - 0.00000000000001291 80.0
TLS2_k127_157772_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001116 285.0
TLS2_k127_157772_1 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000001734 283.0
TLS2_k127_157772_2 Formate hydrogenlyase K12136,K15827 - - 0.0000000000000000000000000000000000000000000000000003387 190.0
TLS2_k127_157772_3 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000000000000002207 168.0
TLS2_k127_157772_4 GYD domain - - - 0.000000000000000000000000000001644 125.0
TLS2_k127_157772_5 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000002438 90.0
TLS2_k127_1579232_0 PFAM Type II secretion system protein E K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008084 475.0
TLS2_k127_1579232_1 Tetratricopeptide repeat - - - 0.000001591 59.0
TLS2_k127_1579232_2 Putative peptidoglycan binding domain - - - 0.000003206 57.0
TLS2_k127_1601917_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 508.0
TLS2_k127_1601917_1 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000009085 223.0
TLS2_k127_1601917_2 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0019899,GO:0030312,GO:0035375,GO:0036293,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.000000000000000006878 85.0
TLS2_k127_1601917_4 - - - - 0.000006976 50.0
TLS2_k127_1605635_0 L,D-transpeptidase catalytic domain K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 376.0
TLS2_k127_1605635_1 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000000000003122 173.0
TLS2_k127_1605635_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0008195 42.0
TLS2_k127_1612171_0 4-hydroxyphenylacetate 3-hydroxylase C terminal K00483 - 1.14.14.9 0.00000000000000000000000000000000000000000000000000008446 191.0
TLS2_k127_1612171_1 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000007454 169.0
TLS2_k127_163921_0 Two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 407.0
TLS2_k127_163921_1 Utp--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 332.0
TLS2_k127_163921_2 signal transduction histidine kinase K02668,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000156 176.0
TLS2_k127_163921_3 Type II secretion system (T2SS), protein F K02653 - - 0.0000000000000000000006507 98.0
TLS2_k127_1653861_0 ABC transporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004166 599.0
TLS2_k127_1653861_1 protein conserved in cyanobacteria - - - 0.00000000000000000000000000000000000000000000000000001922 194.0
TLS2_k127_16549_0 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 420.0
TLS2_k127_16549_1 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004067 308.0
TLS2_k127_16549_2 Thioesterase K07107 - - 0.0000000000000000000000000000000000000000000000000000000000002598 222.0
TLS2_k127_16549_3 MOSC domain - - - 0.000000000000000000000000000000000000000000000295 178.0
TLS2_k127_16549_4 Glycosyltransferase like family 2 - - - 0.000002141 53.0
TLS2_k127_166489_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 5.669e-222 707.0
TLS2_k127_166489_1 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006198 276.0
TLS2_k127_166489_2 SMART PDZ DHR GLGF domain protein K11749 - - 0.00000000000000000000000000000002154 128.0
TLS2_k127_166489_3 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000001622 113.0
TLS2_k127_166489_4 Ferredoxin - - - 0.000000000000000000007544 97.0
TLS2_k127_16770_0 Domain of unknown function (DUF4445) K04755,K08952,K08953,K08954 GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 420.0
TLS2_k127_16770_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003515 282.0
TLS2_k127_16770_10 PFAM PHA accumulation regulator DNA-binding protein - - - 0.00000003136 59.0
TLS2_k127_16770_11 Peptidase M48 K07387 - - 0.00001227 56.0
TLS2_k127_16770_2 Enoyl-(Acyl carrier protein) reductase K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000000000000000000000003984 249.0
TLS2_k127_16770_3 Glucose dehydrogenase C-terminus K00008,K00060 - 1.1.1.103,1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000006475 226.0
TLS2_k127_16770_4 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000008062 226.0
TLS2_k127_16770_5 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000001771 193.0
TLS2_k127_16770_6 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000004209 188.0
TLS2_k127_16770_7 Zn peptidase - - - 0.0000000000000000000000000000000000006132 156.0
TLS2_k127_16770_8 PFAM MaoC like domain - - - 0.000000000000000000000000000000003111 149.0
TLS2_k127_16770_9 EamA-like transporter family - - - 0.0000000000000000003373 98.0
TLS2_k127_172318_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009623 602.0
TLS2_k127_172318_1 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 400.0
TLS2_k127_172318_10 MaoC like domain - - - 0.00000000000000000000000000002183 129.0
TLS2_k127_172318_11 Protein of unknown function (DUF1343) - - - 0.00000007967 62.0
TLS2_k127_172318_2 Chalcone and stilbene synthases, C-terminal domain K16424 GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 2.3.1.246 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 397.0
TLS2_k127_172318_3 SIS domain K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000000000000007112 263.0
TLS2_k127_172318_4 Bacterial transferase hexapeptide (six repeats) - GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008270,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043168,GO:0043169,GO:0043199,GO:0046872,GO:0046914,GO:0050897,GO:0071890,GO:1901681 - 0.00000000000000000000000000000000000000000000000000000000000000000001002 242.0
TLS2_k127_172318_5 TIGRFAM geranylgeranyl reductase K21401 - 1.3.99.38 0.000000000000000000000000000000000000000000000000000000003634 216.0
TLS2_k127_172318_6 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms - - - 0.000000000000000000000000000000000000000000004897 170.0
TLS2_k127_172318_7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline K01304 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:1901564 3.4.19.3 0.000000000000000000000000000000000000000000007612 177.0
TLS2_k127_172318_8 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000009791 162.0
TLS2_k127_172318_9 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000172 131.0
TLS2_k127_174450_0 FAD linked oxidases, C-terminal domain K00102,K00104 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.2.4,1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 478.0
TLS2_k127_174450_1 FAD binding domain K11472 - - 0.00000000000000000000000000000000000000000000000000000000000001084 231.0
TLS2_k127_177616_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 1.147e-200 640.0
TLS2_k127_177616_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 397.0
TLS2_k127_177616_10 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000001607 187.0
TLS2_k127_177616_11 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000005972 164.0
TLS2_k127_177616_12 Forms part of the polypeptide exit tunnel K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000007825 169.0
TLS2_k127_177616_13 Binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000007917 149.0
TLS2_k127_177616_14 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000004379 139.0
TLS2_k127_177616_15 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000004429 143.0
TLS2_k127_177616_16 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000002584 128.0
TLS2_k127_177616_17 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000001002 123.0
TLS2_k127_177616_18 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000003433 108.0
TLS2_k127_177616_19 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000002441 101.0
TLS2_k127_177616_2 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006342 314.0
TLS2_k127_177616_20 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.0000000000000000000004384 107.0
TLS2_k127_177616_21 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000006645 101.0
TLS2_k127_177616_22 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000006419 74.0
TLS2_k127_177616_23 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000004963 77.0
TLS2_k127_177616_24 Ribosomal protein L30 K02907 - - 0.0000000000001431 74.0
TLS2_k127_177616_3 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000189 268.0
TLS2_k127_177616_4 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000001234 258.0
TLS2_k127_177616_5 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 - 0.0000000000000000000000000000000000000000000000000000000000000000009074 234.0
TLS2_k127_177616_6 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000007723 209.0
TLS2_k127_177616_7 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000007746 208.0
TLS2_k127_177616_8 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000002637 205.0
TLS2_k127_177616_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000000000000006879 186.0
TLS2_k127_1811318_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004308 542.0
TLS2_k127_1811318_1 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000001983 155.0
TLS2_k127_1871819_0 formaldehyde dehydrogenase K00153 - 1.1.1.306 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 562.0
TLS2_k127_1871819_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 510.0
TLS2_k127_1871819_10 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - 0.000000000000000000000000000000000000000000000000000002515 192.0
TLS2_k127_1871819_11 DNA-binding protein with PD1-like DNA-binding motif K06934 - - 0.0000000000000000000000000000000000000000000002398 181.0
TLS2_k127_1871819_12 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000002618 116.0
TLS2_k127_1871819_13 - - - - 0.00000000000000000000001502 102.0
TLS2_k127_1871819_14 - - - - 0.000000000000000000000589 96.0
TLS2_k127_1871819_15 - - - - 0.00000000000002295 85.0
TLS2_k127_1871819_16 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.0000000002838 66.0
TLS2_k127_1871819_2 Fatty acid desaturase K00508 - 1.14.19.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005059 444.0
TLS2_k127_1871819_3 peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003611 342.0
TLS2_k127_1871819_4 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 293.0
TLS2_k127_1871819_5 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004392 295.0
TLS2_k127_1871819_6 Belongs to the pseudouridine synthase RsuA family K06181 - 5.4.99.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000001105 262.0
TLS2_k127_1871819_7 FIST C domain - GO:0008150,GO:0040007 - 0.000000000000000000000000000000000000000000000000000000000005439 225.0
TLS2_k127_1871819_8 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - 0.0000000000000000000000000000000000000000000000000000000001216 225.0
TLS2_k127_1871819_9 response regulator receiver K13041 - - 0.000000000000000000000000000000000000000000000000000001443 203.0
TLS2_k127_1872271_0 PFAM Hydantoinase B oxoprolinase K01469,K01474 - 3.5.2.14,3.5.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006705 557.0
TLS2_k127_1872271_1 Hydantoinaseoxoprolinase domain protein K01469,K01473 - 3.5.2.14,3.5.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 339.0
TLS2_k127_1872271_2 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001337 292.0
TLS2_k127_187579_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370,K07306,K17050 - 1.7.5.1,1.8.5.3 0.0 1681.0
TLS2_k127_187579_1 nitrate reductase beta subunit K00371,K17051 - 1.7.5.1 4.443e-211 659.0
TLS2_k127_187579_2 chaperone-mediated protein complex assembly - - - 0.000000000000000000000000000000000000000000000000000002494 202.0
TLS2_k127_187579_3 helix_turn_helix, cAMP Regulatory protein - - - 0.00000009441 61.0
TLS2_k127_1878061_0 COG0168 Trk-type K transport systems, membrane components K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004439 456.0
TLS2_k127_1878061_1 COGs COG0569 K transport systems NAD-binding component K03499,K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001616 281.0
TLS2_k127_1881720_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K05587 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 524.0
TLS2_k127_1881720_1 uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000003614 262.0
TLS2_k127_1881720_2 Asparaginase K13051 - 3.4.19.5 0.0000000000000000000000000000000000000000000000000000000000000000000002658 253.0
TLS2_k127_1881720_3 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K05586 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000254 211.0
TLS2_k127_1881720_4 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000291 129.0
TLS2_k127_1882582_0 Bacterial-like globin K06886 - - 0.000000000000000000000000000000000000000309 153.0
TLS2_k127_1882582_1 - - - - 0.0000000000000000008274 98.0
TLS2_k127_1882582_2 lipolytic protein G-D-S-L family - - - 0.0000000000000004516 89.0
TLS2_k127_1886223_0 - - - - 0.0000000000000000000000000000000000000000000006961 175.0
TLS2_k127_1886223_1 Phage tail protein (Tail_P2_I) - - - 0.00000000000000000000000000000000000000004359 173.0
TLS2_k127_1886223_2 domain, Protein - - - 0.0000000000000000000001186 116.0
TLS2_k127_1886678_0 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007054 365.0
TLS2_k127_1886678_1 - - - - 0.0000112 53.0
TLS2_k127_1891249_0 Myo-inositol-1-phosphate synthase, GAPDH domain protein K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005336 364.0
TLS2_k127_1891249_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01560,K07025,K20862 - 3.1.3.102,3.1.3.104,3.8.1.2 0.00000000000000000000000000000000000000000000000000002275 199.0
TLS2_k127_1891249_2 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon K00966,K05305,K16881 - 2.7.1.52,2.7.7.13,5.4.2.8 0.000000000000000000000000000000000000000000002339 183.0
TLS2_k127_1891249_3 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K03802,K05844 - 6.3.2.29,6.3.2.30 0.00000000000000000000000001751 121.0
TLS2_k127_1893973_0 Flavocytochrome c sulphide dehydrogenase, flavin-binding K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 388.0
TLS2_k127_1893973_1 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008541 383.0
TLS2_k127_1893973_2 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 308.0
TLS2_k127_1893973_3 PFAM response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000000000225 119.0
TLS2_k127_1893973_4 Sulfurtransferase TusA - - - 0.0000000000008955 81.0
TLS2_k127_1898240_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 539.0
TLS2_k127_1898240_1 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000000000001561 99.0
TLS2_k127_1898240_2 Protein conserved in bacteria - - - 0.0000000000001543 76.0
TLS2_k127_19011_0 carbohydrate transport K02027 - - 0.00000000000000000000000000000000000000002721 170.0
TLS2_k127_19011_1 COG1175 ABC-type sugar transport systems, permease components K15771 - - 0.00000000000000001821 89.0
TLS2_k127_1903146_0 AIR synthase related protein, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 307.0
TLS2_k127_1903146_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000002133 167.0
TLS2_k127_1903146_2 Adenylate cyclase, class 2 (Thermophilic) - - - 0.000000000000000000000000000000007828 138.0
TLS2_k127_1905940_0 symbiont process K00612 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008578 554.0
TLS2_k127_1905940_1 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 362.0
TLS2_k127_1905940_2 Glycosyl transferase, family 2 - - - 0.000000000000004715 90.0
TLS2_k127_1918045_0 Sulfatase K01130 - 3.1.6.1 2.428e-287 908.0
TLS2_k127_1918045_1 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 413.0
TLS2_k127_1918045_10 beta-fructofuranosidase activity - - - 0.0000000000000000000000000000000000007068 154.0
TLS2_k127_1918045_11 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.0000000000000000000000000000183 130.0
TLS2_k127_1918045_12 Domain of unknown function (DUF4926) - - - 0.00000000000003112 78.0
TLS2_k127_1918045_13 Periplasmic binding protein LacI transcriptional regulator K02529 - - 0.00009641 49.0
TLS2_k127_1918045_2 Amidohydrolase family K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005968 400.0
TLS2_k127_1918045_3 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 314.0
TLS2_k127_1918045_4 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 300.0
TLS2_k127_1918045_5 permease K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004534 293.0
TLS2_k127_1918045_6 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001462 279.0
TLS2_k127_1918045_7 ATPases associated with a variety of cellular activities K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002098 257.0
TLS2_k127_1918045_8 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component - - - 0.000000000000000000000000000000000000000000000000000000000000000000006607 243.0
TLS2_k127_1918045_9 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000007616 235.0
TLS2_k127_1919468_0 CoA-transferase family III K07544 - 2.8.3.15 5.578e-267 836.0
TLS2_k127_1919468_1 pyridoxamine 5-phosphate - - - 0.0002416 44.0
TLS2_k127_1919910_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 401.0
TLS2_k127_1919910_1 HD domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009808 312.0
TLS2_k127_1919910_2 diguanylate cyclase - - - 0.000000000000000000000000000000000007468 146.0
TLS2_k127_1919910_3 Sulfurtransferase TusA - - - 0.0000000000000005843 85.0
TLS2_k127_1919910_4 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.00000000000001057 80.0
TLS2_k127_1919910_5 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.000000006172 61.0
TLS2_k127_192366_0 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 308.0
TLS2_k127_192366_1 Domain of unknown function (DUF1998) K06877 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.000000000000000000000000002353 124.0
TLS2_k127_192366_2 VanZ like family - - - 0.0000007156 60.0
TLS2_k127_1924407_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003473 621.0
TLS2_k127_1924407_1 fad dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 431.0
TLS2_k127_1924407_2 non-haem dioxygenase in morphine synthesis N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009257 393.0
TLS2_k127_1924407_3 membrane protein, TerC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007719 368.0
TLS2_k127_1924407_4 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 329.0
TLS2_k127_1924407_5 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007996 270.0
TLS2_k127_1924407_6 HAD superfamily, subfamily IIIB (Acid phosphatase) - - - 0.0000000000000000000000000000000000000000000000000004413 194.0
TLS2_k127_1924407_7 - - - - 0.00000001793 59.0
TLS2_k127_1925053_0 PFAM thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006708 380.0
TLS2_k127_1925053_1 Acetyl-CoA hydrolase/transferase N-terminal domain K18122 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 322.0
TLS2_k127_1925053_2 Inosine-uridine preferring nucleoside hydrolase K01239,K01250 - 3.2.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007779 289.0
TLS2_k127_1925053_3 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00847,K00852 GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019303,GO:0019321,GO:0019323,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.15,2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000006623 252.0
TLS2_k127_1925053_4 protein tyrosine/serine/threonine phosphatase activity K14165 GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0004725,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031974,GO:0031981,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0140096,GO:1901564 3.1.3.16,3.1.3.48 0.00000000000000000001433 100.0
TLS2_k127_1925053_5 Contains selenocysteine K07401 - - 0.000001612 51.0
TLS2_k127_1925411_0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively K04099,K04101 - 1.13.11.57,1.13.11.8 0.000000000000000000000000000000000000000000000000000000007126 209.0
TLS2_k127_1925411_1 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000001394 183.0
TLS2_k127_1925411_2 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively K04099,K04101 - 1.13.11.57,1.13.11.8 0.0007475 51.0
TLS2_k127_19427_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 7.186e-209 657.0
TLS2_k127_19427_1 PpiC-type peptidyl-prolyl cis-trans isomerase K03771 - 5.2.1.8 0.000000000000000000000000000000001728 146.0
TLS2_k127_19427_2 Binds the 23S rRNA K02909 - - 0.000000000000000000000003372 108.0
TLS2_k127_19427_3 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.000004376 52.0
TLS2_k127_1942834_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168,K07479 GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 8.828e-254 805.0
TLS2_k127_1942834_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 608.0
TLS2_k127_1942834_10 Belongs to the ComB family K05979 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 0.000000000000000000000000000000000006125 146.0
TLS2_k127_1942834_11 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000000001362 149.0
TLS2_k127_1942834_2 Arginosuccinate synthase K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008988 608.0
TLS2_k127_1942834_3 Aminotransferase class-III K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 459.0
TLS2_k127_1942834_4 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 355.0
TLS2_k127_1942834_5 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 344.0
TLS2_k127_1942834_6 Phage integrase, N-terminal SAM-like domain K03733,K04763 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000002149 267.0
TLS2_k127_1942834_7 DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005 258.0
TLS2_k127_1942834_8 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000001278 237.0
TLS2_k127_1942834_9 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000003555 216.0
TLS2_k127_1943860_0 Adenylate and Guanylate cyclase catalytic domain - - - 6.982e-197 637.0
TLS2_k127_1949160_0 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 537.0
TLS2_k127_1949160_1 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008219 407.0
TLS2_k127_1949160_2 Polysaccharide deacetylase K22278 - 3.5.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008718 387.0
TLS2_k127_1949319_0 DNA helicase K03654 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 359.0
TLS2_k127_1949319_1 glutamine synthetase K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 346.0
TLS2_k127_1949319_2 Dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000642 224.0
TLS2_k127_1950590_0 Sodium:sulfate symporter transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000002762 247.0
TLS2_k127_1955595_0 argininosuccinate lyase K01755 - 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 527.0
TLS2_k127_1955595_1 Diaminopimelate decarboxylase K01586 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 440.0
TLS2_k127_1955595_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007488 342.0
TLS2_k127_1955595_3 Metallo-beta-lactamase superfamily K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 308.0
TLS2_k127_1955595_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009521 305.0
TLS2_k127_1955595_5 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001252 278.0
TLS2_k127_1955595_6 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000004048 247.0
TLS2_k127_1955595_7 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000001458 124.0
TLS2_k127_1955595_8 Fibronectin type 3 domain - - - 0.000000001991 71.0
TLS2_k127_1958725_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K19837 - 3.5.1.84 0.000000000000000000000000000000000000000001208 162.0
TLS2_k127_1958725_1 Staphylococcal nuclease homologue K01174 - 3.1.31.1 0.00000000000000000000000000000000000001542 152.0
TLS2_k127_1960591_0 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 445.0
TLS2_k127_1960591_1 branched-chain amino acid transport system, permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 441.0
TLS2_k127_1960591_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006384 362.0
TLS2_k127_1960591_3 PFAM ABC transporter related K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 301.0
TLS2_k127_1960591_4 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000003539 194.0
TLS2_k127_1963687_0 PFAM glycoside hydrolase family 3 K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000004357 281.0
TLS2_k127_1963687_1 BtpA family K06971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000897 251.0
TLS2_k127_1963687_2 PFAM thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate - - - 0.00000000000000000000000000000000000000000000000004791 181.0
TLS2_k127_1963687_3 Histidine kinase - - - 0.000000000002958 74.0
TLS2_k127_1963687_4 General secretion pathway protein K02453 - - 0.0000000005405 62.0
TLS2_k127_1965964_0 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000001224 165.0
TLS2_k127_1965964_1 COG1024 Enoyl-CoA hydratase carnithine racemase K01692,K08299 - 4.2.1.149,4.2.1.17 0.000000000000000001251 91.0
TLS2_k127_1967463_0 Bifunctional purine biosynthesis protein PurH K00602 GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 539.0
TLS2_k127_1967463_1 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 430.0
TLS2_k127_1967463_2 Formyl transferase K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000002615 238.0
TLS2_k127_1967463_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000002062 169.0
TLS2_k127_1973834_0 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 320.0
TLS2_k127_1973834_1 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000008529 250.0
TLS2_k127_1973834_2 Transporter associated domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000001359 261.0
TLS2_k127_1973834_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000002544 239.0
TLS2_k127_1973834_4 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000002153 134.0
TLS2_k127_1973834_5 Protein of unknown function, DUF393 - - - 0.00002397 49.0
TLS2_k127_1975103_0 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 623.0
TLS2_k127_1975103_1 CHAT domain - - - 0.00008055 52.0
TLS2_k127_197938_0 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 327.0
TLS2_k127_197938_1 Serine Threonine protein kinase - - - 0.0000000000000000000000001471 124.0
TLS2_k127_1985261_0 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 488.0
TLS2_k127_1985261_1 Non-ribosomal peptide synthetase modules and related proteins - - - 0.0000002343 56.0
TLS2_k127_1985544_0 DNA polymerase K02337 GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0 1110.0
TLS2_k127_1985544_1 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 293.0
TLS2_k127_198586_0 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 2.384e-319 987.0
TLS2_k127_198586_1 DNA methylase K07316 - 2.1.1.72 1.582e-315 990.0
TLS2_k127_198586_10 ubiE/COQ5 methyltransferase family - - - 0.0000000001707 71.0
TLS2_k127_198586_2 Belongs to the IlvD Edd family K22396 - 4.2.1.82 3.007e-312 967.0
TLS2_k127_198586_3 Transglycosylase - - - 1.104e-245 794.0
TLS2_k127_198586_4 von Willebrand factor (vWF) type A domain - - - 2.494e-218 696.0
TLS2_k127_198586_5 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03404,K03405 - 6.6.1.1 6.97e-199 629.0
TLS2_k127_198586_6 ABC-type sugar transport system, permease component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002987 310.0
TLS2_k127_198586_7 Type III restriction enzyme, res subunit K01156 - 3.1.21.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001018 286.0
TLS2_k127_198586_8 Binding-protein-dependent transport system inner membrane component K02025,K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001341 254.0
TLS2_k127_198586_9 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000004421 161.0
TLS2_k127_1986357_0 PFAM monooxygenase FAD-binding K20940 - 1.14.13.218 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 524.0
TLS2_k127_1986357_1 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000000000000000004441 119.0
TLS2_k127_1986357_2 Pyridoxamine 5'-phosphate - - - 0.000000000000000008437 90.0
TLS2_k127_1986357_3 Sterol carrier protein - - - 0.00000002916 64.0
TLS2_k127_1986357_4 Glyoxalase-like domain K07032 - - 0.0004045 50.0
TLS2_k127_1989829_0 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000000000000000000000000000000000000005475 183.0
TLS2_k127_1989829_1 PFAM cyclic nucleotide-binding K16922 - - 0.0000000000000000008229 98.0
TLS2_k127_1989829_2 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.0000000904 54.0
TLS2_k127_19901_0 MreB/Mbl protein - - - 3.628e-214 683.0
TLS2_k127_19901_1 Belongs to the heat shock protein 70 family - - - 5.885e-210 686.0
TLS2_k127_19901_2 EVE domain - - - 0.00000000000000000000000000000000000000001071 158.0
TLS2_k127_19901_3 Domain of unknown function (DUF2760) - - - 0.00000000000000000000000000000001211 136.0
TLS2_k127_19901_4 Receptor family ligand binding region K01999 - - 0.000000000001654 71.0
TLS2_k127_1991785_0 TIM-barrel fold metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000273 255.0
TLS2_k127_1991785_1 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000002535 261.0
TLS2_k127_1991785_2 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000001482 239.0
TLS2_k127_1991785_3 Aldo/keto reductase family K18471 - - 0.000000000000000000000000000000000000000000000000000000000000001258 229.0
TLS2_k127_1991785_4 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000007722 167.0
TLS2_k127_1991785_5 PFAM DNA polymerase, beta domain protein region K07076 - - 0.0000000000000000000000000002402 119.0
TLS2_k127_1991785_6 HEPN domain - - - 0.0000000000000000000000000005699 118.0
TLS2_k127_1991785_7 - - - - 0.00000000000000000005956 97.0
TLS2_k127_1994388_0 B12 binding domain K00548 - 2.1.1.13 0.0 1429.0
TLS2_k127_1994388_1 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000004659 230.0
TLS2_k127_1994388_2 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000003858 166.0
TLS2_k127_1998878_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 5.35e-281 874.0
TLS2_k127_1998878_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 585.0
TLS2_k127_1999502_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 304.0
TLS2_k127_1999502_1 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000007804 222.0
TLS2_k127_1999502_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000002419 212.0
TLS2_k127_1999502_3 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000000000007449 86.0
TLS2_k127_1999502_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000006419 74.0
TLS2_k127_1999502_5 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.000000007478 58.0
TLS2_k127_1999788_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 556.0
TLS2_k127_1999788_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008675 332.0
TLS2_k127_1999788_2 Belongs to the UPF0234 family K09767 - - 0.000000000000000000000000000000000000000000000002366 189.0
TLS2_k127_1999788_3 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.0000000000000000000000005884 123.0
TLS2_k127_1999788_4 Tetratricopeptide repeat - - - 0.00000000003474 76.0
TLS2_k127_2008737_0 Copper resistance protein D K07245 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001007 299.0
TLS2_k127_2008737_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000005281 235.0
TLS2_k127_2008737_2 Rhodanese-related sulfurtransferase - - - 0.0000000000000000000000001537 112.0
TLS2_k127_2008737_3 Domain of Unknown Function (DUF748) - - - 0.00000000000008892 83.0
TLS2_k127_2010853_0 PFAM luciferase-like - - - 0.000000000000000000000000000000000000000000000003643 183.0
TLS2_k127_2010853_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000001233 154.0
TLS2_k127_2010853_2 Thioesterase-like superfamily K07107 - - 0.0000000000000167 75.0
TLS2_k127_2010853_3 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0000001337 59.0
TLS2_k127_2020387_0 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008934 552.0
TLS2_k127_2020387_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009198 527.0
TLS2_k127_2020387_2 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 497.0
TLS2_k127_2020387_3 DNA-binding response regulator K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 387.0
TLS2_k127_2020387_4 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004783 295.0
TLS2_k127_2020387_5 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007007 267.0
TLS2_k127_2020387_6 - - - - 0.000000000000000000000000000000000000001481 151.0
TLS2_k127_2020387_7 DinB family - - - 0.0000000000000000000000000000000006291 142.0
TLS2_k127_2028098_0 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000008491 191.0
TLS2_k127_2028098_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000001357 52.0
TLS2_k127_2028098_2 cAMP biosynthetic process K00870,K12132 - 2.7.1.37,2.7.11.1 0.0003775 52.0
TLS2_k127_202850_0 hydrolase, family 65, central catalytic - - - 0.0000000000000000000000000000000000000000000000000000004049 201.0
TLS2_k127_202850_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000005134 69.0
TLS2_k127_202850_2 Glutamine synthetase N-terminal domain K01915 - 6.3.1.2 0.00000007335 54.0
TLS2_k127_2031134_0 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000004297 247.0
TLS2_k127_2031134_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000009925 233.0
TLS2_k127_2031134_2 PAS fold - - - 0.000000000000000001033 87.0
TLS2_k127_203444_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000002 151.0
TLS2_k127_203444_1 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.000000000000000000000000000000005251 133.0
TLS2_k127_203444_2 Alpha beta hydrolase K14731 - 3.1.1.83 0.000000000000000000000000009597 110.0
TLS2_k127_2039743_0 AcrB/AcrD/AcrF family K03296 - - 1.256e-235 767.0
TLS2_k127_2039743_1 MFS/sugar transport protein K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 511.0
TLS2_k127_2039743_10 Predicted membrane protein (DUF2238) K08984 - - 0.00007066 46.0
TLS2_k127_2039743_11 branched-chain amino acid - - - 0.0005682 49.0
TLS2_k127_2039743_2 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 459.0
TLS2_k127_2039743_3 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000004864 202.0
TLS2_k127_2039743_4 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000105 153.0
TLS2_k127_2039743_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.00000000000000000000000000000002074 143.0
TLS2_k127_2039743_6 Nitroreductase family - - - 0.000000000000000000002766 96.0
TLS2_k127_2039743_7 AzlC protein - - - 0.00000000002576 74.0
TLS2_k127_2039743_8 - - - - 0.00000162 59.0
TLS2_k127_2039743_9 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.00002466 51.0
TLS2_k127_2049408_0 Alpha beta hydrolase - - - 0.000000000000000009686 92.0
TLS2_k127_2049408_1 Protein of unknown function (DUF1706) - - - 0.00000000000000001632 94.0
TLS2_k127_2050988_0 PAC2 family - - - 0.000000000000000000000000000000000000000000000000000000000000000003086 238.0
TLS2_k127_2050988_1 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000821 237.0
TLS2_k127_2050988_2 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000002044 170.0
TLS2_k127_2050988_3 sirohydrochlorin cobaltochelatase activity - - - 0.0000000000000000000000008729 112.0
TLS2_k127_2052545_0 His Kinase A (phosphoacceptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 389.0
TLS2_k127_2057125_0 PFAM Alcohol dehydrogenase GroES domain protein K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 580.0
TLS2_k127_2057125_1 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.0000000000000000000000000002796 120.0
TLS2_k127_2057125_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000002431 74.0
TLS2_k127_2063070_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 5.069e-277 882.0
TLS2_k127_206385_0 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007191 375.0
TLS2_k127_206385_1 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000486 124.0
TLS2_k127_206427_0 inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 414.0
TLS2_k127_206427_1 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 310.0
TLS2_k127_206427_2 PFAM extracellular solute-binding protein family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000009 226.0
TLS2_k127_2065079_0 PFAM Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 454.0
TLS2_k127_2065079_1 Rieske [2Fe-2S] domain K19982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008762 311.0
TLS2_k127_2065079_2 metal-dependent hydrolase of the TIM-barrel fold K03392,K22213 - 4.1.1.45,4.1.1.52 0.0000000000000000000000000000001705 132.0
TLS2_k127_2067568_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 3.284e-213 678.0
TLS2_k127_2076490_0 phosphate transport system permease protein K02038 - - 3.658e-201 663.0
TLS2_k127_2076490_1 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008311 626.0
TLS2_k127_2076490_2 PBP superfamily domain K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 503.0
TLS2_k127_2076490_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015318,GO:0015399,GO:0015405,GO:0015415,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0098660,GO:0098661,GO:0099133 3.6.3.27 0.0000000000000000000000000000000000007177 144.0
TLS2_k127_2076490_4 COG1062 Zn-dependent alcohol dehydrogenases, class III K00001,K00121 - 1.1.1.1,1.1.1.284 0.000000000000000000000000007956 111.0
TLS2_k127_2085888_0 ThiF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 443.0
TLS2_k127_2085888_1 COG4166 ABC-type oligopeptide transport system, periplasmic component K02035,K13893 GO:0005575,GO:0005623,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042493,GO:0042597,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.0000000000001877 83.0
TLS2_k127_2088963_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K11177 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114 1.17.1.4 4.035e-214 681.0
TLS2_k127_2088963_1 COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 334.0
TLS2_k127_2088963_2 [2Fe-2S] binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005198 265.0
TLS2_k127_2088963_3 Bacterial periplasmic substrate-binding proteins K10001 GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015813,GO:0015849,GO:0015893,GO:0016595,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070335,GO:0070778,GO:0071702,GO:0071705,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - 0.000002014 57.0
TLS2_k127_2089689_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09697 - 3.6.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000936 338.0
TLS2_k127_2089689_1 ABC-type uncharacterized transport system K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001355 278.0
TLS2_k127_2089689_2 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001183 285.0
TLS2_k127_2090625_0 Phosphate acyltransferases K01897 - 6.2.1.3 3.298e-266 844.0
TLS2_k127_2095701_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 4.555e-279 881.0
TLS2_k127_2095701_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000006049 82.0
TLS2_k127_2107017_0 PFAM Cytochrome C assembly protein K02198 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000987 540.0
TLS2_k127_2107017_1 PFAM binding-protein-dependent transport systems inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 493.0
TLS2_k127_2107017_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972,K02342,K04096,K12472 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 2.7.7.7,6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 452.0
TLS2_k127_2107017_3 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 360.0
TLS2_k127_2107017_4 Cytochrome C assembly protein K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.00000000000000000000000000000000000000000000000000000000000006014 222.0
TLS2_k127_2107017_5 Thioredoxin-like K02199,K03671 - - 0.000000000000000000000000000000000000000000000000000000000002006 216.0
TLS2_k127_2107017_6 PFAM cytochrome c-type biogenesis protein CcmB K02194 - - 0.00000000000000000000000000000000000000001267 162.0
TLS2_k127_2107017_7 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000003495 147.0
TLS2_k127_2107017_8 subunit of a heme lyase K02198,K02200 - - 0.00000000000000000000000006626 124.0
TLS2_k127_2107017_9 tetratricopeptide repeat - - - 0.0005587 52.0
TLS2_k127_2107579_0 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000001535 138.0
TLS2_k127_2107579_1 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000001041 90.0
TLS2_k127_2107579_2 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000004273 87.0
TLS2_k127_2107579_3 HicA toxin of bacterial toxin-antitoxin, - - - 0.00001271 48.0
TLS2_k127_2112649_0 ABC transporter, transmembrane region K06147,K06148,K18889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 520.0
TLS2_k127_2112649_1 ABC transporter, transmembrane region K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 434.0
TLS2_k127_2118560_0 aminopeptidase activity K18028 - 1.13.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 308.0
TLS2_k127_2118560_1 rieske 2fe-2s - - - 0.000000000000000000000000000003195 126.0
TLS2_k127_2121118_0 Methyltransferase domain - - - 0.000000000000000000000000000000000003382 145.0
TLS2_k127_2121118_1 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.0000000002343 75.0
TLS2_k127_2121118_2 protein conserved in bacteria - - - 0.0004688 51.0
TLS2_k127_2122626_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 357.0
TLS2_k127_2122626_1 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003655 348.0
TLS2_k127_2122626_2 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 332.0
TLS2_k127_2124221_0 PFAM binding-protein-dependent transport systems inner membrane component K02042 - - 0.0000000000000000000000000000000000000000000000000000000000001357 220.0
TLS2_k127_2124221_1 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 GO:0006810,GO:0008150,GO:0015716,GO:0051179,GO:0051234,GO:0071702 3.6.3.28 0.00000000000000000000000000000000000000000000000000000003205 201.0
TLS2_k127_2124221_2 formamidase K01455 - 3.5.1.49 0.000000000000000000000000000000000000000000000000004298 199.0
TLS2_k127_2128397_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 2.405e-215 690.0
TLS2_k127_2128397_1 Aspartyl/Asparaginyl beta-hydroxylase K00476,K12979 - 1.14.11.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 401.0
TLS2_k127_2128397_2 Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily K01661 - 4.1.3.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009153 301.0
TLS2_k127_2128397_3 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002252 276.0
TLS2_k127_2128397_4 Radical SAM domain protein K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003268 267.0
TLS2_k127_2128397_5 domain protein - - - 0.00000000000000000000000000000000000000000000000000007467 198.0
TLS2_k127_2128397_6 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000009436 181.0
TLS2_k127_2128397_7 'dna polymerase iii K02341 - 2.7.7.7 0.000000000000000000000000000000000000007499 159.0
TLS2_k127_2128397_8 Protein of unknown function (DUF2914) - - - 0.000000000000000000000000000008783 132.0
TLS2_k127_2128397_9 - - - - 0.00000000000000000791 93.0
TLS2_k127_2149333_0 methyl-accepting chemotaxis protein K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004539 334.0
TLS2_k127_2149333_1 FecR protein - - - 0.0000000000000000000000000000000001689 137.0
TLS2_k127_2149333_2 OmpA family - - - 0.0000000000000000000000000000000003076 146.0
TLS2_k127_2161057_0 enoyl-CoA hydratase - - - 0.000000000000000000000001436 106.0
TLS2_k127_2161057_1 Major facilitator Superfamily - - - 0.0000715 55.0
TLS2_k127_2162318_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003416 493.0
TLS2_k127_2162318_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 500.0
TLS2_k127_218953_0 MacB-like periplasmic core domain K02004 - - 4.413e-245 785.0
TLS2_k127_218953_1 Lipocalin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 435.0
TLS2_k127_218953_2 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007636 253.0
TLS2_k127_2199823_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008105 467.0
TLS2_k127_2199823_1 F420-dependent oxidoreductase - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000114 70.0
TLS2_k127_2199823_2 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000006117 57.0
TLS2_k127_220136_0 tRNA processing K06864,K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 323.0
TLS2_k127_220136_1 PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002521 270.0
TLS2_k127_220136_2 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.000000000000000000000000000000001771 139.0
TLS2_k127_2206757_0 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 466.0
TLS2_k127_2206757_1 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 361.0
TLS2_k127_2206757_2 Glycosyltransferase family 28 C-terminal domain - - - 0.00000000000000000000000000000000000000004478 163.0
TLS2_k127_2211951_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01577,K01652,K03852 - 2.2.1.6,2.3.3.15,4.1.1.8 2.502e-201 644.0
TLS2_k127_2211951_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 619.0
TLS2_k127_2211951_10 Inositol monophosphatase - - - 0.000000000000000000000000000000000000000000000000000005951 199.0
TLS2_k127_2211951_11 PRC-barrel domain - - - 0.0000000001582 73.0
TLS2_k127_2211951_3 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 475.0
TLS2_k127_2211951_4 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052,K11076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002727 428.0
TLS2_k127_2211951_5 Binding-protein-dependent transport system inner membrane component K02054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 337.0
TLS2_k127_2211951_6 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 288.0
TLS2_k127_2211951_7 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000692 296.0
TLS2_k127_2211951_8 Binding-protein-dependent transport system inner membrane component K02053,K02054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001088 280.0
TLS2_k127_2211951_9 Short repeat of unknown function (DUF308) - - - 0.000000000000000000000000000000000000000000000000000000001857 207.0
TLS2_k127_2221701_0 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 592.0
TLS2_k127_2221701_1 GTPase activity K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008198 302.0
TLS2_k127_2221701_2 PFAM WD domain, G-beta repeat - - - 0.0000000000000000000000000000000005903 146.0
TLS2_k127_2221701_3 Gaf domain - - - 0.00000000000002984 86.0
TLS2_k127_2221701_4 Protein of unknown function (DUF1232) - - - 0.00000000008767 76.0
TLS2_k127_2221701_5 Gaf domain - - - 0.0000000005413 68.0
TLS2_k127_222262_1 protein conserved in cyanobacteria - - - 0.000000000000000000000000000000000000000000000006482 179.0
TLS2_k127_222262_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000003126 172.0
TLS2_k127_222262_3 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000005326 174.0
TLS2_k127_2244361_0 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000599 326.0
TLS2_k127_2244361_1 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 302.0
TLS2_k127_2244361_2 P-loop containing region of AAA domain K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000498 282.0
TLS2_k127_2244361_3 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002693 258.0
TLS2_k127_2244361_4 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 0.0000000000000000000009853 101.0
TLS2_k127_2250724_0 Bacterial regulatory protein, Fis family K02481,K07713,K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003802 310.0
TLS2_k127_2250724_1 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.000000000000000000000000000000000000000000000000000000374 201.0
TLS2_k127_2253216_0 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 376.0
TLS2_k127_2253216_1 Binding-protein-dependent transport system inner membrane component K02054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000523 310.0
TLS2_k127_2253216_2 Binding-protein-dependent transport system inner membrane component K02053 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004546 290.0
TLS2_k127_2253216_3 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.000000000000000000000000000000001144 136.0
TLS2_k127_2267614_0 transcriptional regulator K07734 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004554 272.0
TLS2_k127_2267614_1 PFAM FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002804 280.0
TLS2_k127_2267614_2 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005893 259.0
TLS2_k127_2267614_3 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003597 258.0
TLS2_k127_2267614_4 Glycoside hydrolase, family 19 K03791 - - 0.0000000000000000000000000000000000000000000000000000003944 206.0
TLS2_k127_227462_0 symbiont process K00612 - - 3.236e-304 941.0
TLS2_k127_227462_1 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749,K14471,K14472 - 2.8.3.16,2.8.3.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 419.0
TLS2_k127_227462_2 NAD binding K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000002656 276.0
TLS2_k127_227462_3 Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000005673 250.0
TLS2_k127_227462_4 Lipid A Biosynthesis N-terminal domain - - - 0.000000000000000000000000000000000006831 138.0
TLS2_k127_227462_5 Protein-disulfide isomerase - - - 0.0000000000000000000000000000000001436 136.0
TLS2_k127_227462_6 ChrR Cupin-like domain - - - 0.0000000000000001392 87.0
TLS2_k127_227462_7 PFAM Helix-turn-helix - - - 0.00000000004932 69.0
TLS2_k127_227462_8 PFAM PEGA domain - - - 0.00014 49.0
TLS2_k127_2279492_0 ABC transporter K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008937 417.0
TLS2_k127_2279492_1 NMT1/THI5 like K02051 - - 0.00000006117 57.0
TLS2_k127_2279492_2 Endoribonuclease L-PSP - - - 0.0000439 46.0
TLS2_k127_2300833_0 PFAM short-chain dehydrogenase reductase SDR K00023,K00059 - 1.1.1.100,1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 363.0
TLS2_k127_2300833_1 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 352.0
TLS2_k127_2300833_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001728 274.0
TLS2_k127_2300833_3 Belongs to the Nudix hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000905 237.0
TLS2_k127_2300833_4 reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000003788 198.0
TLS2_k127_2300833_5 Low molecular weight phosphotyrosine protein phosphatase K01104,K20201 - 3.1.3.48,3.9.1.2 0.00000000000000001919 96.0
TLS2_k127_2300833_6 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000006944 61.0
TLS2_k127_2301073_0 Dehydrogenase E1 component K00164 - 1.2.4.2 5.937e-280 892.0
TLS2_k127_2301073_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 407.0
TLS2_k127_2301073_2 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 365.0
TLS2_k127_2301073_3 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000001227 256.0
TLS2_k127_2301073_4 heme oxygenase (decyclizing) activity K07145,K21481 - 1.14.99.48,1.14.99.57 0.00000000000000000000000000000000001027 140.0
TLS2_k127_2301073_5 B12 binding domain - - - 0.00000000000000000000000000000009605 131.0
TLS2_k127_23031_0 Histidine Phosphotransfer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009867 441.0
TLS2_k127_2310201_0 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 363.0
TLS2_k127_2310201_1 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 334.0
TLS2_k127_2310201_2 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000002501 184.0
TLS2_k127_2310201_3 - - - - 0.00000000000000000000000000004224 124.0
TLS2_k127_2310201_4 Amidohydrolase K07045 - - 0.0000000000000000005476 87.0
TLS2_k127_2310201_5 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000009129 55.0
TLS2_k127_2310201_6 - - - - 0.0000003777 59.0
TLS2_k127_231609_0 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 412.0
TLS2_k127_231609_1 3-hydroxyacyl-CoA dehydrogenase domain protein K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 351.0
TLS2_k127_231609_2 Receptor family ligand binding region K01999 - - 0.00000000000000001829 91.0
TLS2_k127_231609_3 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000004315 81.0
TLS2_k127_2327900_0 phosphorelay signal transduction system K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000002297 241.0
TLS2_k127_2327900_1 - - - - 0.000000001074 70.0
TLS2_k127_2327900_2 Bacterial protein of unknown function (DUF937) - - - 0.000002885 58.0
TLS2_k127_2332793_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009199 475.0
TLS2_k127_2332793_1 ATP synthesis coupled electron transport K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 460.0
TLS2_k127_2332793_10 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000001212 147.0
TLS2_k127_2332793_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 - 1.6.5.3 0.00000000000000000000000003037 119.0
TLS2_k127_2332793_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K13378 - 1.6.5.3 0.000000000000000000004769 93.0
TLS2_k127_2332793_13 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000003479 93.0
TLS2_k127_2332793_2 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 444.0
TLS2_k127_2332793_3 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 432.0
TLS2_k127_2332793_4 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 435.0
TLS2_k127_2332793_5 Pyruvate dehydrogenase K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 399.0
TLS2_k127_2332793_6 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00162,K00627 - 1.2.4.1,2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 398.0
TLS2_k127_2332793_7 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006514 402.0
TLS2_k127_2332793_8 quinone binding K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 331.0
TLS2_k127_2332793_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000002145 163.0
TLS2_k127_2339957_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 367.0
TLS2_k127_2339957_1 - - - - 0.000000000000000000000000000008475 126.0
TLS2_k127_234707_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01006,K22424 - 2.7.3.13,2.7.9.1 1.518e-315 990.0
TLS2_k127_234707_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 1.881e-207 663.0
TLS2_k127_234707_2 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 3.201e-195 636.0
TLS2_k127_234707_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 509.0
TLS2_k127_234707_4 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006474 424.0
TLS2_k127_234707_5 4-hydroxy-2-oxoglutarate aldolase K18123 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006081,GO:0006082,GO:0006090,GO:0006520,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008700,GO:0009056,GO:0009058,GO:0009063,GO:0009436,GO:0009987,GO:0016053,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0016833,GO:0019470,GO:0019471,GO:0019752,GO:0031974,GO:0032787,GO:0033609,GO:0042219,GO:0042802,GO:0042803,GO:0042866,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046185,GO:0046394,GO:0046395,GO:0046487,GO:0046983,GO:0070013,GO:0071704,GO:0072329,GO:0072330,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901605,GO:1901606 4.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000002101 239.0
TLS2_k127_234707_6 ACT domain K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000004758 217.0
TLS2_k127_234707_7 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000009643 221.0
TLS2_k127_234707_8 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000003186 171.0
TLS2_k127_2348229_0 Hydantoinase B/oxoprolinase - - - 2.243e-194 619.0
TLS2_k127_236230_0 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 329.0
TLS2_k127_236230_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 300.0
TLS2_k127_236230_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 316.0
TLS2_k127_236230_3 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000009065 181.0
TLS2_k127_236230_4 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000004786 151.0
TLS2_k127_236230_5 transglycosylase associated protein - - - 0.000000000442 61.0
TLS2_k127_2363959_0 polygalacturonase activity - - - 0.0000000000000000000000000000000000000000000000000000000000009591 222.0
TLS2_k127_2363959_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000005686 53.0
TLS2_k127_2364344_0 AMP-dependent synthetase - - - 1.996e-251 813.0
TLS2_k127_2364344_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000002172 111.0
TLS2_k127_2364672_0 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00303 - 1.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 560.0
TLS2_k127_2364672_1 HD domain protein K08722 - 3.1.3.89 0.0000006825 53.0
TLS2_k127_2377309_0 e3 binding domain K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000261 191.0
TLS2_k127_2412070_0 Hydantoinase/oxoprolinase - - - 1.969e-210 665.0
TLS2_k127_2420365_0 Aldolase/RraA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009353 251.0
TLS2_k127_2420365_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000005282 153.0
TLS2_k127_2420365_2 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.00000000000000000000005509 100.0
TLS2_k127_2420365_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000001847 100.0
TLS2_k127_2445318_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 349.0
TLS2_k127_2445318_1 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 304.0
TLS2_k127_2449525_0 Uncharacterized ACR, YdiU/UPF0061 family - - - 7.427e-213 671.0
TLS2_k127_2449525_1 Enoyl-CoA hydratase K15866 - 5.3.3.18 0.00000000002605 66.0
TLS2_k127_2466772_0 Amidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 448.0
TLS2_k127_2466772_1 Protein of unknown function (DUF423) - - - 0.0000000000000000000000000000000000000001562 170.0
TLS2_k127_2466772_2 TIR domain - - - 0.0001838 52.0
TLS2_k127_2466772_3 HEPN domain - - - 0.0007 43.0
TLS2_k127_247092_0 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 422.0
TLS2_k127_247092_1 Asparaginase K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007951 346.0
TLS2_k127_247092_2 Isochorismatase family - - - 0.00000000000000000000000000000000000000000007328 168.0
TLS2_k127_247092_3 cytochrome - - - 0.0000000000000000000000000000000000000000001606 166.0
TLS2_k127_247092_4 Serine aminopeptidase, S33 K06889 - - 0.000000000000000000000002938 104.0
TLS2_k127_247092_5 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000005317 70.0
TLS2_k127_2492161_0 Oligopeptide/dipeptide transporter, C-terminal region K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 460.0
TLS2_k127_2492161_1 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 462.0
TLS2_k127_2492161_10 Putative regulatory protein - - - 0.00000000000000000000000000000000001143 139.0
TLS2_k127_2492161_11 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.00000002274 59.0
TLS2_k127_2492161_12 Rubredoxin-like zinc ribbon domain (DUF35_N) - - - 0.00002045 57.0
TLS2_k127_2492161_2 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 417.0
TLS2_k127_2492161_3 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 420.0
TLS2_k127_2492161_4 PFAM glycosyl transferase group 1 K15521 - 2.4.1.250 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 392.0
TLS2_k127_2492161_5 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004892 376.0
TLS2_k127_2492161_6 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009139 308.0
TLS2_k127_2492161_7 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000001373 246.0
TLS2_k127_2492161_8 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000005769 179.0
TLS2_k127_2492161_9 4Fe-4S binding domain K05524 - - 0.00000000000000000000000000000000000002103 144.0
TLS2_k127_249868_0 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007269 297.0
TLS2_k127_249868_1 PFAM Binding-protein-dependent transport system inner membrane component K02050,K15554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007325 246.0
TLS2_k127_249868_2 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000001009 192.0
TLS2_k127_249868_3 ABC transporter, phosphonate, periplasmic substrate-binding protein K02051 - - 0.000000000000000000000000000000000000000000425 171.0
TLS2_k127_249868_4 Dehydrogenase reductase sdr K00059 - 1.1.1.100 0.000000000000000000000000000000000000000001015 167.0
TLS2_k127_249868_5 LVIVD repeat - - - 0.00000000000000000000006701 106.0
TLS2_k127_249868_6 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000001102 68.0
TLS2_k127_249868_7 KR domain - - - 0.000000004404 60.0
TLS2_k127_2526147_0 Protein of unknown function (DUF3365) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 404.0
TLS2_k127_2526147_1 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000008399 164.0
TLS2_k127_2526147_2 - - - - 0.00000000000000000000000000000000001011 140.0
TLS2_k127_2526147_3 - - - - 0.00000000000000000000000000738 114.0
TLS2_k127_2526147_4 - - - - 0.00000000000000000007308 96.0
TLS2_k127_25342_0 dehydrogenase - - - 4.16e-202 647.0
TLS2_k127_2537686_0 Permease K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004937 331.0
TLS2_k127_2537686_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 300.0
TLS2_k127_2537686_2 Carboxymuconolactone decarboxylase family - - - 0.000001831 55.0
TLS2_k127_2551862_0 Transposase mutator type - - - 1.536e-212 664.0
TLS2_k127_2558857_0 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 429.0
TLS2_k127_2558857_1 PFAM Transketolase K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005712 276.0
TLS2_k127_2558857_2 Transketolase K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000001508 269.0
TLS2_k127_2558857_3 sirohydrochlorin cobaltochelatase activity - - - 0.000000000000000003103 85.0
TLS2_k127_2558857_4 enzyme active site formation K03187 - - 0.00000000000000002625 91.0
TLS2_k127_2558857_5 Regulatory protein, FmdB family - - - 0.0008767 48.0
TLS2_k127_255916_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 2.825e-206 673.0
TLS2_k127_255916_1 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000006892 237.0
TLS2_k127_255916_2 Homocysteine S-methyltransferase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000002911 240.0
TLS2_k127_255916_3 Rhodanese domain protein - - - 0.0000000000000000000000000000002278 127.0
TLS2_k127_255916_4 NOG21937 non supervised orthologous group K00548 - 2.1.1.13 0.00000000000000003544 95.0
TLS2_k127_256257_0 PFAM nickel-dependent hydrogenase large subunit K00436 - 1.12.1.2 2.01e-214 676.0
TLS2_k127_256257_1 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 453.0
TLS2_k127_256257_10 PFAM Copper resistance protein CopC K07156 - - 0.00000000000000000002874 101.0
TLS2_k127_256257_11 TIGRFAM hydrogenase maturation protease - - - 0.000000000000000265 84.0
TLS2_k127_256257_12 AsmA-like C-terminal region K07289 - - 0.00000000444 69.0
TLS2_k127_256257_2 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 410.0
TLS2_k127_256257_3 4Fe-4S ferredoxin iron-sulfur binding domain protein K05588 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 344.0
TLS2_k127_256257_4 Peptidase M16 K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001187 293.0
TLS2_k127_256257_5 PFAM NADH ubiquinone oxidoreductase, 20 K18007 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000006346 256.0
TLS2_k127_256257_6 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000003347 208.0
TLS2_k127_256257_7 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000002611 164.0
TLS2_k127_256257_8 Thioredoxin - - - 0.00000000000000000000000000000000000003203 149.0
TLS2_k127_256257_9 Outer membrane lipoprotein Slp family K07285 - - 0.0000000000000000000000004084 113.0
TLS2_k127_256477_0 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005315 323.0
TLS2_k127_256477_1 Glycosyl transferase K20444 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000106 285.0
TLS2_k127_256477_2 - - - - 0.00000000000000000000000000004684 128.0
TLS2_k127_256477_3 Methyltransferase domain - - - 0.00000000000000006967 91.0
TLS2_k127_256477_4 Methyltransferase domain - - - 0.00004433 55.0
TLS2_k127_2589666_0 Biotin carboxylase C-terminal domain - - - 0.0 1080.0
TLS2_k127_2589666_1 Chitin-binding domain type 3 - - - 0.00000000000000000000000000000000000001251 147.0
TLS2_k127_2643516_0 Multicopper oxidase K22348 - 1.16.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003986 629.0
TLS2_k127_2643516_1 Copper resistance protein D K07245 - - 0.000000000000000000000000000000000000000000000000000000000000000000003592 257.0
TLS2_k127_2643516_2 Domain of unkown function (DUF1775) - - - 0.00000000000000000000000000000000000000000000000000000000000002863 220.0
TLS2_k127_2643516_3 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000000000000000000000000000000000000001624 194.0
TLS2_k127_2643516_4 Pfam Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000003918 170.0
TLS2_k127_2643516_5 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000000000000000000000009971 129.0
TLS2_k127_2643516_7 transposase IS116 IS110 IS902 family protein - - - 0.00025 45.0
TLS2_k127_2674424_0 chaperone-mediated protein complex assembly - - - 0.0000000000000000000000000000000000000000000000000009009 186.0
TLS2_k127_2674424_1 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000003837 109.0
TLS2_k127_2674424_2 chaperone-mediated protein complex assembly - - - 0.000000000000000000009366 104.0
TLS2_k127_271539_0 COG3970 Fumarylacetoacetate (FAA) hydrolase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 479.0
TLS2_k127_271539_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0001183 55.0
TLS2_k127_2715641_0 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000712 121.0
TLS2_k127_2715641_1 Major facilitator superfamily K06610,K08369 - - 0.00000000000000000000000002316 117.0
TLS2_k127_2715641_2 Putative heavy-metal-binding - - - 0.000000000000000000000001154 112.0
TLS2_k127_275190_0 PFAM amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 526.0
TLS2_k127_275190_1 Bacterial extracellular solute-binding protein K02055 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003271 259.0
TLS2_k127_275190_2 Binding-protein-dependent transport system inner membrane component K02054 - - 0.0000000000000000000000000000000000000000000000000000000000003499 227.0
TLS2_k127_275190_3 Binding-protein-dependent transport system inner membrane component K02053 - - 0.000000000000000000000000000000000000000000000000000000000003777 228.0
TLS2_k127_2770079_0 Amidohydrolase family - - - 0.00000000000000000000000000000002468 138.0
TLS2_k127_2770079_1 Thioredoxin - - - 0.0000000000000000000000002032 117.0
TLS2_k127_2797413_0 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969,K03574 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 0.000000000000000000000000000000000000000000000000000006307 198.0
TLS2_k127_2797413_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000942 162.0
TLS2_k127_2797413_2 OsmC-like protein - - - 0.000007621 56.0
TLS2_k127_2807473_0 FAD linked oxidases, C-terminal domain K00102,K00104 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.2.4,1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 556.0
TLS2_k127_2807473_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 378.0
TLS2_k127_2807473_2 - - - - 0.00000000000000000000000000000000000000148 158.0
TLS2_k127_2807473_3 FAD binding domain K11472 - - 0.000000000000000000000678 98.0
TLS2_k127_2811392_0 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000971 434.0
TLS2_k127_2811392_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000354 168.0
TLS2_k127_2813900_0 4Fe-4S dicluster domain K00184 - - 9.522e-211 692.0
TLS2_k127_2813900_1 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008492 580.0
TLS2_k127_2813900_10 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000001746 109.0
TLS2_k127_2813900_11 ThiF family K03148,K03636,K21029,K21147 - 2.7.7.73,2.7.7.80,2.8.1.11 0.000000000000000000006283 96.0
TLS2_k127_2813900_12 Transcriptional regulator - - - 0.00000000000000000006261 106.0
TLS2_k127_2813900_13 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00007138 47.0
TLS2_k127_2813900_2 Belongs to the ALAD family K01698 GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007905 502.0
TLS2_k127_2813900_3 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 505.0
TLS2_k127_2813900_4 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 436.0
TLS2_k127_2813900_5 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008255 273.0
TLS2_k127_2813900_6 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.0000000000000000000000000000000000000000000000000000382 201.0
TLS2_k127_2813900_7 proteolysis K21140,K21147 - 2.7.7.80,2.8.1.11,3.13.1.6 0.000000000000000000000000000004735 128.0
TLS2_k127_2813900_8 Pfam Polysulphide reductase, NrfD - - - 0.0000000000000000000000006484 119.0
TLS2_k127_2813900_9 Protein of unknown function (DUF3341) - - - 0.000000000000000000000003641 119.0
TLS2_k127_2816214_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001068 247.0
TLS2_k127_2816214_1 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.000000000000000000000000000000000000000000000000000000000000000002893 241.0
TLS2_k127_2816214_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000957 198.0
TLS2_k127_2817347_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 6.53e-235 742.0
TLS2_k127_2817347_1 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 433.0
TLS2_k127_2817347_2 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000000000000000000002607 102.0
TLS2_k127_2826515_0 PFAM Aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004469 573.0
TLS2_k127_2826515_1 homoserine dehydrogenase K00003 GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 415.0
TLS2_k127_2826515_2 PFAM Peptidase M23 - - - 0.00000000000000000000000000000000000000004923 163.0
TLS2_k127_2826515_3 ABC-type transport auxiliary lipoprotein component K09857 - - 0.0000000003111 64.0
TLS2_k127_2831417_0 NMT1-like family K07080 - - 0.00000000000000000000000000000000000000000001653 169.0
TLS2_k127_2831417_1 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000001039 87.0
TLS2_k127_2831417_2 Domain of unknown function (DUF2088) - - - 0.000002831 53.0
TLS2_k127_2834621_0 protein involved in ubiquinone biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002432 278.0
TLS2_k127_2834621_1 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000003069 190.0
TLS2_k127_2836991_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02652 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 1.251e-200 642.0
TLS2_k127_2836991_1 Type II secretion system (T2SS), protein F K02455,K02653 GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 384.0
TLS2_k127_2836991_2 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000004142 169.0
TLS2_k127_2836991_3 ECF sigma factor - - - 0.000000000000000000000000000000000003929 149.0
TLS2_k127_2839549_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 6.2.1.1 0.0 1092.0
TLS2_k127_2839549_1 Histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003985 555.0
TLS2_k127_2839549_10 Virulence factor - - - 0.00000000000002272 77.0
TLS2_k127_2839549_12 cheY-homologous receiver domain - - - 0.0006895 47.0
TLS2_k127_2839549_2 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003697 386.0
TLS2_k127_2839549_3 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000002338 258.0
TLS2_k127_2839549_4 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000001844 237.0
TLS2_k127_2839549_5 Protein of unknown function (DUF3494) - - - 0.0000000000000000000000000000000000000000000000000000313 206.0
TLS2_k127_2839549_6 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000001763 159.0
TLS2_k127_2839549_7 - K07039,K09858 - - 0.0000000000000000000000000005937 123.0
TLS2_k127_2839549_8 RNA recognition motif - - - 0.000000000000000000000000001804 116.0
TLS2_k127_2839549_9 O-antigen ligase like membrane protein - - - 0.00000000000000005904 94.0
TLS2_k127_2839555_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 2.045e-194 618.0
TLS2_k127_2839555_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000001269 218.0
TLS2_k127_2839555_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000001521 108.0
TLS2_k127_2839555_3 UvrD REP helicase K03657 - 3.6.4.12 0.000000000006371 69.0
TLS2_k127_28406_0 ABC transporter transmembrane region K06147,K18890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004729 549.0
TLS2_k127_28406_1 ABC-type multidrug transport system ATPase and permease K18889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 388.0
TLS2_k127_28406_10 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000448 147.0
TLS2_k127_28406_11 PFAM Glyoxalase bleomycin resistance protein dioxygenase K08234 - - 0.0000000000000000000000447 107.0
TLS2_k127_28406_12 methylated DNA-protein cysteine methyltransferase K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 - 0.0000000000000000000005065 103.0
TLS2_k127_28406_13 Redoxin - - - 0.0000000000000000008594 89.0
TLS2_k127_28406_14 Protein of unknown function (DUF1285) K09986 - - 0.00000000001598 73.0
TLS2_k127_28406_15 Redoxin - - - 0.00000009866 63.0
TLS2_k127_28406_2 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 286.0
TLS2_k127_28406_3 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000001768 266.0
TLS2_k127_28406_4 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000002335 252.0
TLS2_k127_28406_5 Inositol monophosphatase K01092 GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000001329 239.0
TLS2_k127_28406_6 Belongs to the UPF0282 family K07022 - - 0.0000000000000000000000000000000000000000000000000000000004395 214.0
TLS2_k127_28406_7 P-aminobenzoate N-oxygenase AurF - - - 0.00000000000000000000000000000000000000000000000001035 193.0
TLS2_k127_28406_8 YbaK prolyl-tRNA synthetase associated - - - 0.0000000000000000000000000000000000000001602 164.0
TLS2_k127_28406_9 Memo-like protein K06990 - - 0.00000000000000000000000000000000000003746 150.0
TLS2_k127_2840688_0 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004632 337.0
TLS2_k127_2840688_1 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000004577 207.0
TLS2_k127_2840688_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000001864 104.0
TLS2_k127_2843614_0 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 535.0
TLS2_k127_2844256_0 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005156 561.0
TLS2_k127_2844256_1 N-methylhydantoinase B acetone carboxylase alpha subunit K01474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0017168,GO:0034641,GO:0043603,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071704,GO:1901564 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005434 509.0
TLS2_k127_2844256_10 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000008142 118.0
TLS2_k127_2844256_11 Protein of unknown function (DUF433) - - - 0.0001519 53.0
TLS2_k127_2844256_2 Berberine and berberine like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000725 493.0
TLS2_k127_2844256_3 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 437.0
TLS2_k127_2844256_4 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 314.0
TLS2_k127_2844256_5 Amidase K02433,K19837 - 3.5.1.84,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007955 301.0
TLS2_k127_2844256_6 ABC transporter K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004298 297.0
TLS2_k127_2844256_7 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000007968 203.0
TLS2_k127_2844256_8 NMT1-like family - - - 0.0000000000000000000000000000000000000005584 162.0
TLS2_k127_2844256_9 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000225 125.0
TLS2_k127_2844647_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000001638 265.0
TLS2_k127_2844647_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000001574 251.0
TLS2_k127_2844647_2 Regulatory protein - - - 0.000000000000000000000000001037 116.0
TLS2_k127_2844647_3 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000002249 101.0
TLS2_k127_2844647_4 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000001466 76.0
TLS2_k127_2844647_5 Major facilitator Superfamily - - - 0.000003781 49.0
TLS2_k127_2847676_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000909 366.0
TLS2_k127_2847676_1 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - 0.0000000000000000000000000000000000000000000000000000000001737 207.0
TLS2_k127_2847676_2 Belongs to the proline racemase family K01777 - 5.1.1.4 0.000000000000000000000000008504 114.0
TLS2_k127_2847987_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1070.0
TLS2_k127_2847987_1 PFAM AMP-dependent synthetase and ligase - - - 1.568e-231 728.0
TLS2_k127_2847987_10 Belongs to the Fur family K09825 - - 0.00000000000000000000000000001355 127.0
TLS2_k127_2847987_2 acetyl-coa acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 555.0
TLS2_k127_2847987_3 Amino-transferase class IV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 411.0
TLS2_k127_2847987_4 AAA domain (Cdc48 subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009434 383.0
TLS2_k127_2847987_5 4 iron, 4 sulfur cluster binding K00113,K00176,K05524,K13795,K13796 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 371.0
TLS2_k127_2847987_6 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 309.0
TLS2_k127_2847987_7 Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000000001473 232.0
TLS2_k127_2847987_8 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000001487 169.0
TLS2_k127_2847987_9 Protein of unknown function (DUF3501) - - - 0.000000000000000000000000000000000002345 147.0
TLS2_k127_2848162_0 Trypsin-like serine protease K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006905 307.0
TLS2_k127_2848162_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.000000000000000000007847 97.0
TLS2_k127_2848738_0 SMP-30/Gluconolaconase/LRE-like region K01053,K14274 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009838 586.0
TLS2_k127_2848738_1 Trehalose utilisation K15538,K21132 - 3.2.1.130,3.2.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000522 264.0
TLS2_k127_2848738_2 AMP-binding enzyme C-terminal domain K00666 - - 0.00001098 48.0
TLS2_k127_2854103_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 425.0
TLS2_k127_2854103_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006172 259.0
TLS2_k127_2854103_2 Luciferase-like monooxygenase - - - 0.000000000000000001164 87.0
TLS2_k127_2859338_0 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 554.0
TLS2_k127_2859338_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 451.0
TLS2_k127_2859338_2 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 372.0
TLS2_k127_2859338_3 Domain of unknown function (DUF4157) - - - 0.00000000000000000000000000000000004719 145.0
TLS2_k127_2859338_4 isochorismatase hydrolase - - - 0.0000000000000000000000000000002245 134.0
TLS2_k127_2860411_0 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 3.955e-202 657.0
TLS2_k127_2860411_1 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 544.0
TLS2_k127_2860411_2 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 433.0
TLS2_k127_2860411_3 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 413.0
TLS2_k127_2860411_4 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 368.0
TLS2_k127_2860411_5 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003871 299.0
TLS2_k127_2860411_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000003076 240.0
TLS2_k127_2860411_7 - - - - 0.000000000000000000000000000000000000000000000001896 194.0
TLS2_k127_2860411_8 Zinc-binding dehydrogenase K00004 - 1.1.1.303,1.1.1.4 0.000000000000000000000000000000000001214 148.0
TLS2_k127_2860411_9 - - - - 0.0000000000002371 77.0
TLS2_k127_2862286_0 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004528 416.0
TLS2_k127_2862286_1 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 315.0
TLS2_k127_2862286_2 CoA-transferase family III - - - 0.000000000000000000000000000000000000002543 162.0
TLS2_k127_2862286_3 YjbR - - - 0.000000000000000000000000000000003124 134.0
TLS2_k127_2863537_0 Non-ribosomal peptide synthetase modules and related proteins - - - 2.743e-294 939.0
TLS2_k127_2863537_1 Non-ribosomal peptide synthetase modules and related proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 556.0
TLS2_k127_2863537_2 non-ribosomal peptide synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 377.0
TLS2_k127_2864_0 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 328.0
TLS2_k127_2864_1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides K01465 - 3.5.2.3 0.000000000000000000001363 100.0
TLS2_k127_2864_2 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000007663 79.0
TLS2_k127_2871607_0 PFAM aminotransferase, class I K00812,K10907 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 443.0
TLS2_k127_2871607_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000737 202.0
TLS2_k127_2871607_2 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000003928 190.0
TLS2_k127_2871607_3 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000005698 139.0
TLS2_k127_2871607_4 carbon monoxide dehydrogenase subunit G K09386 - - 0.00000000000000000000002092 107.0
TLS2_k127_2879011_0 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 396.0
TLS2_k127_2879011_1 Nitronate monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004213 270.0
TLS2_k127_2879011_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000005748 226.0
TLS2_k127_2879011_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000003379 124.0
TLS2_k127_2879939_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009541 545.0
TLS2_k127_2879939_1 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006026 528.0
TLS2_k127_2879939_10 YbaK prolyl-tRNA synthetase associated region - - - 0.00000000000000000000000000000000000000009147 161.0
TLS2_k127_2879939_11 - - - - 0.00000000000000000000000000000000000004362 147.0
TLS2_k127_2879939_12 Pfam:DUF385 - - - 0.000000000000000000003823 98.0
TLS2_k127_2879939_13 Psort location CytoplasmicMembrane, score K09790 - - 0.0001623 49.0
TLS2_k127_2879939_2 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 392.0
TLS2_k127_2879939_3 Acetamidase/Formamidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 324.0
TLS2_k127_2879939_4 Protein of unknown function (DUF3750) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003707 282.0
TLS2_k127_2879939_5 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002709 256.0
TLS2_k127_2879939_6 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases K16422 - 1.1.3.46 0.000000000000000000000000000000000000000000000000000000000000000000000003763 259.0
TLS2_k127_2879939_7 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000007168 224.0
TLS2_k127_2879939_8 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000000000000001978 199.0
TLS2_k127_2879939_9 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000004519 199.0
TLS2_k127_2880307_0 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 4.537e-290 915.0
TLS2_k127_2880307_1 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004607 246.0
TLS2_k127_2880511_0 methyl-accepting chemotaxis K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001462 273.0
TLS2_k127_2880511_1 ABC transporter K01996 - - 0.0000000000000000000000059 104.0
TLS2_k127_2880511_3 NifU-like N terminal domain K04488 - - 0.0000000000000000005476 87.0
TLS2_k127_2880511_4 PFAM AMP-binding enzyme - - - 0.000000000000000002347 91.0
TLS2_k127_2880511_5 Iron-sulfur cluster assembly protein - - - 0.000000000000001735 82.0
TLS2_k127_2884887_0 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007006 318.0
TLS2_k127_2884887_1 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005476 321.0
TLS2_k127_2884887_2 PFAM Aminotransferase, class IV K00824 - 2.6.1.21 0.0004795 46.0
TLS2_k127_2888931_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 339.0
TLS2_k127_2888931_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K19837 - 3.5.1.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 315.0
TLS2_k127_2889879_0 peptidyl-tyrosine sulfation - - - 0.000000000000000000007691 107.0
TLS2_k127_2889879_1 Amidohydrolase - - - 0.0000000000000004603 83.0
TLS2_k127_2890764_0 ABC-type uncharacterized transport system K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006965 339.0
TLS2_k127_2890764_1 Metallo-beta-lactamase superfamily K01069 GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000006666 240.0
TLS2_k127_2890764_2 Domain of unknown function (DUF4340) - - - 0.00000000000000000000000000000008961 143.0
TLS2_k127_2891287_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 496.0
TLS2_k127_2891287_1 Aminotransferase class-V - GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004853 417.0
TLS2_k127_2891287_2 Histidyl-tRNA synthetase K00765,K01892,K02502 - 2.4.2.17,6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 393.0
TLS2_k127_2891287_3 Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005164 299.0
TLS2_k127_2891287_4 Phosphoglycerate mutase family K22305 - 3.1.3.3 0.000000000000000000000000000000000000004679 153.0
TLS2_k127_2891476_0 xanthine dehydrogenase activity K03520 - 1.2.5.3 0.0 1009.0
TLS2_k127_2891476_1 Associated with various cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 391.0
TLS2_k127_2891476_2 VWA domain containing CoxE-like protein K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003559 309.0
TLS2_k127_2891476_3 xanthine dehydrogenase activity K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 303.0
TLS2_k127_2891476_4 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003321 282.0
TLS2_k127_2891476_5 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000004214 261.0
TLS2_k127_2891476_6 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.000000000000000000000000000000000000000000000000000000000000003822 231.0
TLS2_k127_2891476_7 'Molybdopterin - - - 0.0000000000000000000000000000000000000000000000000000000003013 219.0
TLS2_k127_2891476_8 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.00000000000000000000000000002017 129.0
TLS2_k127_2891985_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1236.0
TLS2_k127_2891985_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 600.0
TLS2_k127_2891985_10 Protein involved in phosphogluconate dehydrogenase (decarboxylating) activity, 3-hydroxyisobutyrate dehydrogenase activity, 2-hydroxy-3-oxopropionate reductase activity, pentose-phosphate shunt, valine metabolism and glyoxylate metabolism K00020,K00042 - 1.1.1.31,1.1.1.60 0.0001373 48.0
TLS2_k127_2891985_2 transport system periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000998 351.0
TLS2_k127_2891985_3 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000005731 241.0
TLS2_k127_2891985_4 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000007029 223.0
TLS2_k127_2891985_5 PFAM Deoxyhypusine synthase K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000008252 183.0
TLS2_k127_2891985_7 transporter solute receptor, DctP family - - - 0.000000000000000000000002103 116.0
TLS2_k127_2891985_8 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000007814 93.0
TLS2_k127_2891985_9 Hypothetical methyltransferase - - - 0.0000000000000009401 87.0
TLS2_k127_2893421_0 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 526.0
TLS2_k127_2893421_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000002032 259.0
TLS2_k127_2893421_2 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000004933 224.0
TLS2_k127_2894639_0 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 390.0
TLS2_k127_2894639_1 Belongs to the cysteine synthase cystathionine beta- synthase family K12339,K21148 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.113,2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 369.0
TLS2_k127_2894639_2 Protein of unknown function (DUF692) K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 342.0
TLS2_k127_2894639_3 Putative DNA-binding domain - - - 0.0000000000000000000000000000000000000000001654 170.0
TLS2_k127_2894639_4 PFAM NIPSNAP family containing protein - - - 0.00000000000000000000000000000007888 128.0
TLS2_k127_2894639_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000217 113.0
TLS2_k127_2894728_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004492 600.0
TLS2_k127_2894728_1 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000005369 215.0
TLS2_k127_2894728_2 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS K03518,K07302,K12528 GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 1.2.5.3,1.3.99.16 0.000000000000000000000000000000000000000002493 177.0
TLS2_k127_2894728_3 carbon monoxide dehydrogenase subunit G K09386 - - 0.000000000002162 73.0
TLS2_k127_2895426_0 dipeptide transport K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 422.0
TLS2_k127_2895426_1 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 297.0
TLS2_k127_2895426_2 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K15582 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000963 310.0
TLS2_k127_2895426_3 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000002951 239.0
TLS2_k127_2896266_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 8.755e-321 1007.0
TLS2_k127_2897284_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000002283 187.0
TLS2_k127_2897284_1 PFAM CBS domain K04767 - - 0.000000000000000000000000000000004542 136.0
TLS2_k127_2897284_2 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000003496 130.0
TLS2_k127_2897284_3 Redoxin - - - 0.0007044 46.0
TLS2_k127_2900741_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0 1067.0
TLS2_k127_2900741_1 PFAM aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 6.906e-312 973.0
TLS2_k127_2900741_10 YMGG-like Gly-zipper - - - 0.0000000000000000000001011 107.0
TLS2_k127_2900741_11 Nitroreductase family - - - 0.0000000000000000000005428 105.0
TLS2_k127_2900741_12 - - - - 0.000000000001353 79.0
TLS2_k127_2900741_2 ABC-type dipeptide transport system periplasmic component K02035 - - 1.572e-264 826.0
TLS2_k127_2900741_3 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 517.0
TLS2_k127_2900741_4 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00322 - 1.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008228 477.0
TLS2_k127_2900741_5 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 451.0
TLS2_k127_2900741_6 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 399.0
TLS2_k127_2900741_7 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005534 376.0
TLS2_k127_2900741_8 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 331.0
TLS2_k127_2900741_9 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000001421 151.0
TLS2_k127_2901018_0 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002826 266.0
TLS2_k127_2901018_1 Pfam:Pyridox_oxidase - - - 0.00000000000000001452 90.0
TLS2_k127_2901018_2 - - - - 0.0000000001487 70.0
TLS2_k127_2903473_0 Oxidoreductase molybdopterin binding domain K07147 GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0016672,GO:0016675,GO:0019538,GO:0030091,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0043546,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0055114,GO:0071704,GO:0097159,GO:1901363,GO:1901530,GO:1901564,GO:1901700 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 451.0
TLS2_k127_2903473_1 soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000000001316 179.0
TLS2_k127_2903473_2 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.0000000000000000000000000000000000000007716 154.0
TLS2_k127_2903473_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000000000000001812 146.0
TLS2_k127_2903473_4 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000004192 102.0
TLS2_k127_2903473_5 RDD family - - - 0.0006165 53.0
TLS2_k127_2908748_0 Adenylosuccinate lyase C-terminus K01756,K01857 - 4.3.2.2,5.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006736 421.0
TLS2_k127_2908748_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001311 272.0
TLS2_k127_2908748_2 Protein conserved in bacteria - - - 0.0000000000000000000000000000007996 124.0
TLS2_k127_2908748_3 - - - - 0.000000000000000000001133 110.0
TLS2_k127_2910215_0 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 355.0
TLS2_k127_2910215_1 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000000000001668 168.0
TLS2_k127_2910215_2 AraC-like ligand binding domain - - - 0.00000000000000000000000000000003069 132.0
TLS2_k127_2910215_3 Protein of unknown function (DUF3455) - - - 0.000000000000000000000001781 109.0
TLS2_k127_2910215_4 AraC-like ligand binding domain - - - 0.0000000000000000000001906 109.0
TLS2_k127_2910215_5 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.0001451 53.0
TLS2_k127_2910215_6 DNA integration K14059 - - 0.0008308 50.0
TLS2_k127_2910852_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972,K02342,K04096,K12472 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 2.7.7.7,6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 375.0
TLS2_k127_2910852_1 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.0000000000000000000000000000000000000000001795 175.0
TLS2_k127_291103_0 PFAM Asparagine synthase K01953 - 6.3.5.4 1.269e-240 758.0
TLS2_k127_291103_1 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000006752 190.0
TLS2_k127_2912286_0 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004404 436.0
TLS2_k127_2912286_1 Histidine kinase-like ATPase domain - - - 0.0000000000000004062 82.0
TLS2_k127_2912292_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004054 621.0
TLS2_k127_2912292_1 His Kinase A (phosphoacceptor) domain K02484,K07636,K07768 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 481.0
TLS2_k127_2912292_2 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006864 299.0
TLS2_k127_2912292_3 Two component transcriptional regulator, winged helix family K07658,K07668 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004379 278.0
TLS2_k127_2912292_4 Exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000003952 171.0
TLS2_k127_2912292_5 Protein of unknown function (DUF3225) - - - 0.00000000000000000000000000000000001428 138.0
TLS2_k127_2912292_6 phosphorelay signal transduction system K07712 - - 0.000000000105 71.0
TLS2_k127_2912292_7 - - - - 0.00008977 49.0
TLS2_k127_2913686_0 - - - - 0.00000000000000000000000006859 118.0
TLS2_k127_2913686_1 Serine aminopeptidase, S33 - - - 0.0000000000000000004161 102.0
TLS2_k127_2914381_0 DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 406.0
TLS2_k127_2914381_1 Luciferase-like monooxygenase - - - 0.00000000000000001308 85.0
TLS2_k127_2914381_2 DNA-sulfur modification-associated - - - 0.000000001822 69.0
TLS2_k127_2917346_0 Amidase K02433 - 6.3.5.6,6.3.5.7 4.813e-197 632.0
TLS2_k127_2917346_1 NMT1-like family - - - 0.0000000000000000000000000000000000000000000000000000000000007331 220.0
TLS2_k127_2921764_0 transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 307.0
TLS2_k127_2921764_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09697 - 3.6.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000001116 257.0
TLS2_k127_2921764_2 Metallo-beta-lactamase superfamily K13075 - 3.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000001495 244.0
TLS2_k127_2921764_3 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000001235 144.0
TLS2_k127_2921764_4 Domain of unknown function (DUF4340) - - - 0.00000000000003784 83.0
TLS2_k127_2921764_5 Domain of unknown function (DUF3482) - - - 0.00000000004365 66.0
TLS2_k127_2921764_6 HupE / UreJ protein - - - 0.00004207 51.0
TLS2_k127_2924265_0 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 293.0
TLS2_k127_2924265_1 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000976 266.0
TLS2_k127_2924265_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.000000000000000000000000000000000000000004275 164.0
TLS2_k127_2924265_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000001409 94.0
TLS2_k127_2924265_4 Protein of unknown function (DUF1706) - - - 0.0000000008385 72.0
TLS2_k127_2927067_0 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 312.0
TLS2_k127_2927067_1 ATP-grasp domain K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000001736 230.0
TLS2_k127_2927067_2 Prolyl oligopeptidase family - - - 0.00000000000000000000000004149 123.0
TLS2_k127_2927067_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000002283 95.0
TLS2_k127_2929101_0 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 332.0
TLS2_k127_2929101_1 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 293.0
TLS2_k127_2930828_0 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008203 378.0
TLS2_k127_2930828_1 Condensation domain - - - 0.00000000000000000004185 105.0
TLS2_k127_2932198_0 FAD binding domain K13796 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 564.0
TLS2_k127_2932198_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 386.0
TLS2_k127_2932198_2 COG2513 PEP phosphonomutase and related enzymes K01841 - 5.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004075 340.0
TLS2_k127_2932198_3 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001862 256.0
TLS2_k127_2932198_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000002214 199.0
TLS2_k127_2932198_5 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000000001611 175.0
TLS2_k127_2932511_0 Linear amide C-N hydrolases, choloylglycine hydrolase family K01442 - 3.5.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 544.0
TLS2_k127_2932511_1 Belongs to the LDH2 MDH2 oxidoreductase family K16844 - 1.1.1.338 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006483 441.0
TLS2_k127_2932511_2 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 331.0
TLS2_k127_2932511_3 Sulfate permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009568 338.0
TLS2_k127_2932511_4 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 291.0
TLS2_k127_2932511_5 branched-chain amino acid ABC transporter ATP-binding protein K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 287.0
TLS2_k127_2932511_6 'PFAM Taurine catabolism dioxygenase TauD, TfdA family' - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000766 263.0
TLS2_k127_2932511_7 abc transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000001459 254.0
TLS2_k127_2932511_8 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.000000000983 62.0
TLS2_k127_2932765_0 Alanine dehydrogenase/PNT, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000008843 233.0
TLS2_k127_2932765_1 Beta-eliminating lyase K01620 - 4.1.2.48 0.0000000426 57.0
TLS2_k127_2932765_2 transcriptional regulator, SARP family - - - 0.000000578 56.0
TLS2_k127_2935485_0 COG0553 Superfamily II DNA RNA - - - 1.494e-292 921.0
TLS2_k127_2935485_1 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.0000004119 54.0
TLS2_k127_2935485_2 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source K10778 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0071944 2.1.1.63 0.00006465 48.0
TLS2_k127_2937057_0 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008341 353.0
TLS2_k127_2945852_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000002206 241.0
TLS2_k127_2945852_1 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000007218 180.0
TLS2_k127_2945852_2 Metal-dependent phosphohydrolase, HD region - - - 0.0000000000000000000000000000000000000000000000884 179.0
TLS2_k127_2945852_3 Histidine kinase - - - 0.000000000000000000000000000000000000000004864 175.0
TLS2_k127_2945852_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000001037 137.0
TLS2_k127_2945852_5 Protein of unknown function (DUF507) - - - 0.0000005163 55.0
TLS2_k127_2945852_6 Protein of unknown function (DUF507) - - - 0.0000008996 57.0
TLS2_k127_294798_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 393.0
TLS2_k127_294798_1 DnaJ molecular chaperone homology domain K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006339 267.0
TLS2_k127_294798_2 MerR HTH family regulatory protein K18997 - - 0.000000001139 66.0
TLS2_k127_2948466_0 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009045 293.0
TLS2_k127_2948466_1 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000004464 211.0
TLS2_k127_2948466_2 DegT/DnrJ/EryC1/StrS aminotransferase family K10907 - - 0.0000000000000000000000000000000000000000000000001201 182.0
TLS2_k127_2948466_3 Molybdopterin converting factor, small subunit K03636 - - 0.000000000000000000000000000002773 129.0
TLS2_k127_2952849_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1316.0
TLS2_k127_2952849_1 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002612 265.0
TLS2_k127_2952849_2 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.0000000000257 69.0
TLS2_k127_2953647_0 Type I restriction enzyme R protein N terminus (HSDR_N) K01153 - 3.1.21.3 0.0 1157.0
TLS2_k127_2953647_1 AAA domain - - - 7.18e-251 812.0
TLS2_k127_2953647_2 AAA domain K07133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 478.0
TLS2_k127_2953647_3 Transposase (IS116 IS110 IS902 family) - - - 0.00000000000000000000000000007276 125.0
TLS2_k127_2953647_4 Transposase - - - 0.0000000000000000000000000091 117.0
TLS2_k127_2953647_6 nuclease activity K06218 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000007818 99.0
TLS2_k127_2953647_7 toxin-antitoxin pair type II binding K08591,K19159 GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141 2.3.1.15 0.00000005661 60.0
TLS2_k127_2957343_0 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 1.707e-218 710.0
TLS2_k127_2957343_1 Alcohol dehydrogenase, iron containing, 1 K11173 GO:0003674,GO:0003824,GO:0004022,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006103,GO:0006520,GO:0006536,GO:0006538,GO:0006539,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0047988,GO:0051186,GO:0055114,GO:0070013,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.1.99.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 347.0
TLS2_k127_2957343_2 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000005427 75.0
TLS2_k127_2959408_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002394 369.0
TLS2_k127_2959408_1 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000699 210.0
TLS2_k127_2962666_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.434e-201 644.0
TLS2_k127_2962666_1 Amidohydrolase K07045 - - 1.353e-198 628.0
TLS2_k127_2962666_2 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 366.0
TLS2_k127_2962992_0 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 476.0
TLS2_k127_2962992_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000003168 239.0
TLS2_k127_2962992_2 PFAM Bacterial protein of - - - 0.0000000000001772 76.0
TLS2_k127_2962992_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000001163 69.0
TLS2_k127_2962992_4 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.000000003151 59.0
TLS2_k127_2962992_5 Taurine catabolism dioxygenase TauD, TfdA family K22303 - - 0.0009685 48.0
TLS2_k127_2967616_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004598 314.0
TLS2_k127_2967616_1 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 312.0
TLS2_k127_2970683_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 338.0
TLS2_k127_2970683_1 Alkylmercury lyase - - - 0.000000000000000000000000000000000001276 144.0
TLS2_k127_2970683_2 - - - - 0.0000000000000000000000000000000002498 151.0
TLS2_k127_2970683_3 PFAM NHL repeat containing protein - - - 0.0000000006455 60.0
TLS2_k127_2970683_4 NHL repeat - - - 0.00000003134 60.0
TLS2_k127_2970683_6 C-terminal four TMM region of protein-O-mannosyltransferase - - - 0.0000007405 62.0
TLS2_k127_2970683_7 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000168 51.0
TLS2_k127_2979790_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 2.163e-229 717.0
TLS2_k127_2979790_1 DNA-binding transcription factor activity K02521 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 311.0
TLS2_k127_2979790_2 HD domain protein K08722 - 3.1.3.89 0.000000000000000000000000000000000000000000000000000000000000000001094 233.0
TLS2_k127_2979790_3 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00303 - 1.5.3.1 0.00000000000000000000000000000000000000006297 153.0
TLS2_k127_2979790_4 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00000000000000000000000000000000000001059 146.0
TLS2_k127_2979790_5 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.00000000000000000000000000000000003516 142.0
TLS2_k127_2982691_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 395.0
TLS2_k127_2982691_1 Peptidase family M50 K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000008275 238.0
TLS2_k127_2982691_2 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.00000000001838 64.0
TLS2_k127_2987483_0 MFS_1 like family - - - 0.000000000000000000000000000000000000000251 168.0
TLS2_k127_2987483_1 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.00000000000000000000000000000000000002362 156.0
TLS2_k127_2987483_2 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000006149 115.0
TLS2_k127_2987899_0 Domain of unknown function (DUF4143) K07133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004015 287.0
TLS2_k127_2987899_1 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000001298 122.0
TLS2_k127_2987899_2 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07667 - - 0.0000001878 60.0
TLS2_k127_2988282_0 4-hydroxyphenylacetate 3-hydroxylase C terminal - - - 3.205e-235 743.0
TLS2_k127_2991232_0 ATPase component of ABC-type sugar transporter K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006621 347.0
TLS2_k127_2991232_1 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000368 224.0
TLS2_k127_2991232_2 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000007767 221.0
TLS2_k127_2991232_3 PFAM binding-protein-dependent transport systems inner membrane component K02025,K10118,K10237 - - 0.000000000000000000000000000000000000000000000000000003937 202.0
TLS2_k127_2993851_0 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008737 464.0
TLS2_k127_2993851_1 PFAM response regulator receiver K07665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001464 284.0
TLS2_k127_2993851_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07644 - 2.7.13.3 0.000000000000007876 86.0
TLS2_k127_2994199_0 protein kinase activity - - - 0.000000000000000000000000000000000003844 155.0
TLS2_k127_2994199_1 Pfam:KaiC - - - 0.0000000000000000000001536 112.0
TLS2_k127_2997419_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 437.0
TLS2_k127_2997419_1 NIPSNAP - - - 0.0000000000000000000000000000000000000000002008 167.0
TLS2_k127_2997419_2 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000002183 162.0
TLS2_k127_2998377_0 Elongation factor SelB, winged helix K03833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 586.0
TLS2_k127_2998377_1 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 417.0
TLS2_k127_2998377_2 Protein of unknown function (DUF3105) - - - 0.0000000000000000000000000000000000000000357 162.0
TLS2_k127_2998377_3 L-lactate dehydrogenase K00101,K16422 - 1.1.2.3,1.1.3.46 0.0000000000000000000000000007448 117.0
TLS2_k127_2998377_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000008874 66.0
TLS2_k127_3001417_0 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 521.0
TLS2_k127_3001417_1 ATPases associated with a variety of cellular activities K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 395.0
TLS2_k127_3001417_2 Bacterial extracellular solute-binding protein K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 362.0
TLS2_k127_3001417_3 Binding-protein-dependent transport system inner membrane component K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 327.0
TLS2_k127_3001417_4 Binding-protein-dependent transport system inner membrane component K02054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 320.0
TLS2_k127_3001417_5 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000000000000000000007606 218.0
TLS2_k127_3001417_6 Ureidoglycolate lyase - - - 0.0000000000000000000000000000000000000000000000000000006376 196.0
TLS2_k127_3001417_7 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.0000000000000000000000000000000000000003889 159.0
TLS2_k127_3001417_8 Integrase core domain K07497 - - 0.0001315 52.0
TLS2_k127_3001676_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007136 611.0
TLS2_k127_3001676_1 multidrug resistance K15549 GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072348,GO:1901474,GO:1901682,GO:1902599 - 0.00000000000000000000000000000000000000000000000000000000000000003095 227.0
TLS2_k127_3001676_2 Resistance protein K15547 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:1901474,GO:1901682,GO:1902599 - 0.000000000000000000000000000000000000000008017 176.0
TLS2_k127_3001676_3 dehydratase - - - 0.0000000000000001034 84.0
TLS2_k127_3002840_0 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000002693 198.0
TLS2_k127_3002840_1 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000007256 190.0
TLS2_k127_3002840_2 hydrolase (HAD superfamily) K07025 - - 0.000000000000000000000000000001469 139.0
TLS2_k127_3002840_3 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.00000000000000000000000000006402 128.0
TLS2_k127_3002840_4 Rhodanese Homology Domain - - - 0.00000000000000000000000001335 116.0
TLS2_k127_3002840_5 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000008254 95.0
TLS2_k127_3005899_0 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005101 402.0
TLS2_k127_3005899_1 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000009048 148.0
TLS2_k127_300738_0 AMP-binding enzyme C-terminal domain K00666 - - 1.982e-267 836.0
TLS2_k127_300738_1 - - - - 0.0000000000000000000000000000002347 134.0
TLS2_k127_3011099_0 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 442.0
TLS2_k127_3011099_1 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 324.0
TLS2_k127_3011099_2 beta-lactamase - - - 0.0000000000000000000000000000000000000000000002404 171.0
TLS2_k127_3011099_3 Belongs to the enoyl-CoA hydratase isomerase family K08299,K16426 GO:0003674,GO:0003824,GO:0004300,GO:0016829,GO:0016835,GO:0016836 4.2.1.149 0.0007365 43.0
TLS2_k127_3012134_0 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007121 419.0
TLS2_k127_3012134_1 PFAM CBS domain containing protein K04767 - - 0.00000008294 59.0
TLS2_k127_3024077_0 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 430.0
TLS2_k127_3028896_0 Rhamnan synthesis protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 340.0
TLS2_k127_3028896_1 Glycosyltransferase like family K20444 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 347.0
TLS2_k127_3028896_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001808 301.0
TLS2_k127_3028896_3 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000007207 205.0
TLS2_k127_3031430_0 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000000001118 213.0
TLS2_k127_3031430_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000004184 96.0
TLS2_k127_3031430_2 carboxylic ester hydrolase activity K16050 - 3.7.1.17 0.00000002358 58.0
TLS2_k127_3035320_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003299 419.0
TLS2_k127_3035320_1 PFAM binding-protein-dependent transport systems inner membrane component K02033,K12369,K13890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 316.0
TLS2_k127_3035320_2 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005749 297.0
TLS2_k127_3035320_3 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 294.0
TLS2_k127_3035320_4 Aldose 1-epimerase K01792 - 5.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 296.0
TLS2_k127_3035320_5 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007363 290.0
TLS2_k127_3035320_6 PFAM Tetratricopeptide - - - 0.00000000000000000000000000000008298 144.0
TLS2_k127_3035320_7 peptidyl-tyrosine sulfation - - - 0.000000009279 69.0
TLS2_k127_303657_0 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 370.0
TLS2_k127_303657_1 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000003466 142.0
TLS2_k127_3046037_0 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000001361 208.0
TLS2_k127_3046037_1 Glycoprotease family K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.00000000000000000000000000000000000000005794 158.0
TLS2_k127_3046037_2 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.0000000000000000000000000000000000007001 145.0
TLS2_k127_3053025_0 EXOIII K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000086 231.0
TLS2_k127_3053025_1 Putative nucleotidyltransferase DUF294 K07182 - - 0.00004733 48.0
TLS2_k127_3054010_0 Type VI secretion protein, EvpB/VC_A0108, tail sheath K11900 - - 2.795e-258 818.0
TLS2_k127_3054010_1 Sel1 domain protein repeat-containing protein K07126 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 434.0
TLS2_k127_3054010_2 Type VI secretion protein, VC_A0107 family K11901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 284.0
TLS2_k127_3054010_3 TIGRFAM type VI secretion-associated protein, ImpA family K11902 - - 0.00000000000000000000000000000000000000000000000000000000000000000001479 249.0
TLS2_k127_3054010_4 TIGRFAM Type VI secretion system effector, Hcp1 K11903 - - 0.000000000000000000000000000000000000000000000000000000000000000157 225.0
TLS2_k127_3054010_5 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000006838 234.0
TLS2_k127_3054010_6 Protein phosphatase 2C K20074 - 3.1.3.16 0.000000000000000000001776 109.0
TLS2_k127_3054010_7 COG4455 Protein of avirulence locus involved in temperature-dependent protein secretion K11898 - - 0.00000000001205 72.0
TLS2_k127_3054361_0 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006773 343.0
TLS2_k127_3054361_1 cheY-homologous receiver domain - - - 0.000000000000000000000000000000002764 129.0
TLS2_k127_3056638_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000008855 231.0
TLS2_k127_3056638_1 Maleate cis-trans isomerase K01799 - 5.2.1.1 0.0000000000000000000001102 105.0
TLS2_k127_3057189_0 FAD dependent oxidoreductase K00109,K15736 - 1.1.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 490.0
TLS2_k127_3057189_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.000000000000000000000000000000006291 136.0
TLS2_k127_3057189_2 PFAM Lytic K08309 - - 0.0000000000000002593 87.0
TLS2_k127_3057189_3 SNARE associated Golgi protein K03975 - - 0.00000000000002361 86.0
TLS2_k127_3057189_4 Peptidase s1 and s6 chymotrypsin hap K08372 - - 0.00000000000007246 85.0
TLS2_k127_3057189_5 Cyclic nucleotide-monophosphate binding domain K03321,K10914 - - 0.00000000001074 70.0
TLS2_k127_308607_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 6.277e-216 679.0
TLS2_k127_308607_1 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 341.0
TLS2_k127_3088662_0 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007192 334.0
TLS2_k127_3088662_1 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 320.0
TLS2_k127_3100746_0 4fe-4S ferredoxin, iron-sulfur binding domain protein K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 428.0
TLS2_k127_3100746_1 FAD binding domain K11472 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000866 262.0
TLS2_k127_3100746_2 Rieske-like [2Fe-2S] domain K00363 - 1.7.1.15 0.0000000000000003148 93.0
TLS2_k127_3101551_0 GTP-binding protein LepA C-terminus K03596 - - 2.584e-240 767.0
TLS2_k127_3101551_1 alpha beta alpha domain I K00966,K16881 - 2.7.7.13,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000008269 234.0
TLS2_k127_3101551_2 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000002651 231.0
TLS2_k127_3101551_3 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000009293 92.0
TLS2_k127_3104443_0 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009622 435.0
TLS2_k127_3104443_1 - - - - 0.0000000000000000000009955 103.0
TLS2_k127_3104443_2 Aminotransferase, class I K05825 - - 0.00000000000000003534 87.0
TLS2_k127_3107186_0 Alanine dehydrogenase/PNT, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003097 408.0
TLS2_k127_3107186_1 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.000000000000000000000000000000000000000000000000000000001189 212.0
TLS2_k127_3107186_2 Protein of unknown function (DUF502) - - - 0.000001398 59.0
TLS2_k127_3108630_0 Belongs to the HpcH HpaI aldolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009204 273.0
TLS2_k127_3108630_1 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000238 213.0
TLS2_k127_3108630_2 Major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000001795 126.0
TLS2_k127_3108630_3 PFAM Mandelate racemase muconate lactonizing - - - 0.0000000000000000000002882 99.0
TLS2_k127_3115536_0 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003812 280.0
TLS2_k127_3115536_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.00000000000002635 82.0
TLS2_k127_3129123_0 elongation factor G K02355 - - 5.77e-230 731.0
TLS2_k127_3129123_1 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 1.334e-216 706.0
TLS2_k127_3129123_10 decarboxylase K01607 - 4.1.1.44 0.0000003789 51.0
TLS2_k127_3129123_2 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 525.0
TLS2_k127_3129123_3 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 399.0
TLS2_k127_3129123_4 NmrA-like family K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 368.0
TLS2_k127_3129123_5 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 303.0
TLS2_k127_3129123_6 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000003143 258.0
TLS2_k127_3129123_7 Carotenoid biosynthesis protein - - - 0.000000000000000000000000000000000000000000000001089 185.0
TLS2_k127_3129123_8 - - - - 0.000000000000000000000001933 107.0
TLS2_k127_3129123_9 Phosphorylase superfamily K01243 - 3.2.2.9 0.0000000000002465 80.0
TLS2_k127_3129859_0 Phage tail sheath C-terminal domain K06907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005692 445.0
TLS2_k127_3129859_1 Protein of unknown function (DUF4255) - - - 0.0000000000000000000000000000000000000003057 157.0
TLS2_k127_3129859_2 T4-like virus tail tube protein gp19 - - - 0.00000000000000000000000000000000000003635 145.0
TLS2_k127_3133044_0 xanthine dehydrogenase activity K04108 - 1.3.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007737 598.0
TLS2_k127_3133044_1 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000794 229.0
TLS2_k127_313347_0 Oxidoreductase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005770,GO:0006810,GO:0008150,GO:0008152,GO:0012505,GO:0016192,GO:0016197,GO:0016482,GO:0016491,GO:0031410,GO:0031982,GO:0042147,GO:0043226,GO:0043227,GO:0043229,GO:0044424,GO:0044444,GO:0044464,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055114,GO:0097708 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006673 324.0
TLS2_k127_3135729_0 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 317.0
TLS2_k127_3136637_0 TIGRFAM peptidase T-like protein K01258 - 3.4.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000693 285.0
TLS2_k127_3136637_1 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001156 274.0
TLS2_k127_3136637_2 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000002435 251.0
TLS2_k127_3136637_3 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000003061 222.0
TLS2_k127_3136637_4 Methyltransferase domain - - - 0.000000000000000000001523 109.0
TLS2_k127_3147284_0 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000593 356.0
TLS2_k127_3147284_1 Cytidylate kinase-like family - - - 0.00000000000000000000000000000006412 136.0
TLS2_k127_3147284_2 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000003792 75.0
TLS2_k127_31585_0 Pup-ligase protein K13571 GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 0.000000000000000000000000000000000000000000005291 184.0
TLS2_k127_31585_1 AI-2E family transporter - - - 0.000000000009587 73.0
TLS2_k127_31585_2 WD40 repeats K20332 - - 0.00004873 56.0
TLS2_k127_3159320_0 Belongs to the thiolase family K00626 - 2.3.1.9 4.658e-200 629.0
TLS2_k127_3159320_1 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 511.0
TLS2_k127_3159320_10 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000004846 59.0
TLS2_k127_3159320_11 positive regulation of growth - - - 0.00008879 48.0
TLS2_k127_3159320_2 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 449.0
TLS2_k127_3159320_3 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 376.0
TLS2_k127_3159320_4 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005838 334.0
TLS2_k127_3159320_5 branched-chain amino acid transport K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 295.0
TLS2_k127_3159320_6 Branched-chain amino acid ATP-binding cassette transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000019 281.0
TLS2_k127_3159320_7 COG1061 DNA or RNA helicases of superfamily II - - - 0.0000000000000000000000000000000000000000000000000000000000001795 224.0
TLS2_k127_3159320_8 Protein of unknown function (DUF790) - - - 0.000000000000000000000000000000000002935 154.0
TLS2_k127_3159320_9 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.0000000002149 66.0
TLS2_k127_3168084_0 Hydantoinase B/oxoprolinase - - - 3.52e-225 712.0
TLS2_k127_3168084_1 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000005181 213.0
TLS2_k127_3171824_0 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 390.0
TLS2_k127_3171824_1 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006332 338.0
TLS2_k127_3171824_2 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000007651 152.0
TLS2_k127_3171824_3 Cupin domain - - - 0.000000000000682 68.0
TLS2_k127_3178799_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 537.0
TLS2_k127_3178799_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0000000000000000007561 89.0
TLS2_k127_3185501_0 Short-chain dehydrogenase reductase sdr K00023,K00059 - 1.1.1.100,1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 287.0
TLS2_k127_3185501_1 - - - - 0.00000000000000000000000000000000000000000000002307 173.0
TLS2_k127_3185501_2 Glycine-rich RNA-binding protein - - - 0.000000000000000000001979 99.0
TLS2_k127_3189042_0 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002923 260.0
TLS2_k127_3189042_1 COG0433 Predicted ATPase K06915 - - 0.000000000000000000000000000000000000000000001436 167.0
TLS2_k127_3189042_2 ATPase involved in DNA repair K03546 - - 0.0001125 48.0
TLS2_k127_3201453_0 Nitrile hydratase K01721,K20762 - 3.5.5.8,4.2.1.84 0.000000000000000000000000000000000000000000000000000001566 194.0
TLS2_k127_3201453_1 ligase activity, forming nitrogen-metal bonds K02230 - 6.6.1.2 0.000000000000000000000000000000000000000000000007547 183.0
TLS2_k127_3201453_2 Nitrile hydratase beta subunit - - - 0.00000000000000006262 91.0
TLS2_k127_3207063_0 D-amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000124 289.0
TLS2_k127_3207063_1 Protein of unknown function (DUF1272) - - - 0.0000000000000000000000000000002289 133.0
TLS2_k127_3207063_2 ThiF family - - - 0.0000000000000000000000000000005669 128.0
TLS2_k127_3207063_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000008239 125.0
TLS2_k127_3214454_0 Hydrophobe Amphiphile Efflux-1 (HAE1) Family K03296,K18138 - - 1.555e-249 786.0
TLS2_k127_3214454_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion K18145 - - 0.00000008033 55.0
TLS2_k127_3217520_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005841 371.0
TLS2_k127_3217520_1 Enoyl-(Acyl carrier protein) reductase K00059,K00068 - 1.1.1.100,1.1.1.140 0.0000000000000000000000000000000000000000000000000000000000000000000001387 259.0
TLS2_k127_3217520_2 PFAM 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000000000004774 222.0
TLS2_k127_3217520_3 lipopolysaccharide transmembrane transporter activity K03303,K07058 - - 0.0000000000000000329 92.0
TLS2_k127_3217520_4 Prolyl oligopeptidase family - - - 0.0001591 47.0
TLS2_k127_322220_0 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000275 268.0
TLS2_k127_322220_1 PFAM ABC transporter related K01990 - - 0.0001193 46.0
TLS2_k127_3240776_0 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 381.0
TLS2_k127_3240776_1 8-oxoguanine DNA glycosylase K01247 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003905,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008725,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0032131,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0043733,GO:0043916,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.21 0.000000000000000000000000000000000003834 149.0
TLS2_k127_3240776_2 FR47-like protein - - - 0.0000008417 60.0
TLS2_k127_3240776_3 Protein of unknown function (DUF971) - - - 0.0001785 51.0
TLS2_k127_3244099_0 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 331.0
TLS2_k127_3244099_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005003 310.0
TLS2_k127_3251559_0 PFAM General secretion pathway protein K K02460 - - 0.000000000000000000002109 108.0
TLS2_k127_3251559_1 Pilus assembly protein K02461,K02662,K02663,K12289 - - 0.0000000000000006486 92.0
TLS2_k127_3256037_0 dipeptide transport K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004528 497.0
TLS2_k127_3256037_1 Bacterial protein of unknown function (DUF853) K06915 - - 0.00000000000000000000000000000000000000000001322 166.0
TLS2_k127_3256037_2 serine threonine protein kinase K08884 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009405,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010565,GO:0016020,GO:0016021,GO:0016036,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031667,GO:0031668,GO:0031669,GO:0032091,GO:0033554,GO:0036211,GO:0042304,GO:0042594,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043393,GO:0043412,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051100,GO:0051704,GO:0051716,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.00005895 54.0
TLS2_k127_3256132_0 Imidazolonepropionase and related amidohydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004893 287.0
TLS2_k127_3256132_1 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004474 258.0
TLS2_k127_3256132_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000004671 160.0
TLS2_k127_3256132_3 COG1062 Zn-dependent alcohol dehydrogenases, class III K00001,K00121 - 1.1.1.1,1.1.1.284 0.000000000000000000000000007956 111.0
TLS2_k127_3267106_0 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001347 289.0
TLS2_k127_3267106_1 Acetamidase/Formamidase family - - - 0.000000000000000000000000000002578 122.0
TLS2_k127_3267106_2 - - - - 0.000000000000000000000000009334 120.0
TLS2_k127_326938_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 329.0
TLS2_k127_326938_1 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 303.0
TLS2_k127_326938_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001405 287.0
TLS2_k127_326938_3 Domain of unknown function (DUF4115) K15539 - - 0.0000000000000000000000001675 117.0
TLS2_k127_3271643_0 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005221 327.0
TLS2_k127_3271643_1 Belongs to the glycosyl hydrolase 43 family - - - 0.000000000000007221 88.0
TLS2_k127_3288423_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0 1450.0
TLS2_k127_3299535_0 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003876 332.0
TLS2_k127_3299535_1 Phenazine biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 310.0
TLS2_k127_3299535_2 Patatin-like phospholipase K07001 - - 0.000000005089 63.0
TLS2_k127_3301435_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 469.0
TLS2_k127_3301435_1 YacP-like NYN domain K06962 - - 0.0000000000007748 77.0
TLS2_k127_330496_0 - K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009594 298.0
TLS2_k127_330496_1 Amidohydrolase family K01464,K01466 - 3.5.2.2,3.5.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000001078 294.0
TLS2_k127_330496_2 Carbon-nitrogen hydrolase K01459 - 3.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000002771 243.0
TLS2_k127_330496_3 MmgE/PrpD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000002802 240.0
TLS2_k127_3312284_0 NADH pyrophosphatase-like rudimentary NUDIX domain K03426 - 3.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000006641 250.0
TLS2_k127_3312284_1 cell redox homeostasis K00383 - 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000001584 209.0
TLS2_k127_3312284_2 PFAM Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000001581 146.0
TLS2_k127_3315275_0 ABC transporter transmembrane region K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005779 355.0
TLS2_k127_3315275_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001446 287.0
TLS2_k127_3349462_0 Protein of unknown function (DUF1207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 308.0
TLS2_k127_3349462_1 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000004982 93.0
TLS2_k127_3351168_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.939e-211 670.0
TLS2_k127_3351168_1 PFAM extracellular solute-binding protein family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000003337 233.0
TLS2_k127_3353608_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 5.163e-233 743.0
TLS2_k127_3353608_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 6.809e-212 681.0
TLS2_k127_3353608_2 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000003227 248.0
TLS2_k127_3353608_3 DHHA1 domain K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000009822 249.0
TLS2_k127_3353608_4 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000004134 239.0
TLS2_k127_3353608_5 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000002216 134.0
TLS2_k127_3353608_6 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000009893 107.0
TLS2_k127_3353608_7 Protein of unknown function (DUF503) K09764 - - 0.0000000000000000004672 91.0
TLS2_k127_3381328_0 Domain of unknown function (DUF5009) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 321.0
TLS2_k127_3381328_1 Bacterial extracellular solute-binding protein K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 327.0
TLS2_k127_3388006_0 GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009911 390.0
TLS2_k127_3388006_1 PFAM Rhodanese domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009162 372.0
TLS2_k127_3388006_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 336.0
TLS2_k127_3388006_3 Ribonuclease, BN K07058 - - 0.00000000000000000000000000000000000000000000000003073 192.0
TLS2_k127_3388006_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000001482 175.0
TLS2_k127_3388006_5 - - - - 0.000000000000000000000000000000001532 137.0
TLS2_k127_3388006_6 PAS fold - - - 0.000000000000000000000000000003782 141.0
TLS2_k127_3394533_0 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000002006 220.0
TLS2_k127_3394533_1 Winged helix DNA-binding domain K09927 - - 0.0000000000000000000000000000000000000000005723 169.0
TLS2_k127_3394533_2 D-alanine [D-alanyl carrier protein] ligase activity - - - 0.0000000002332 72.0
TLS2_k127_3397184_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007183 597.0
TLS2_k127_3397184_1 Antitoxin component of a toxin-antitoxin (TA) module - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.0000001848 56.0
TLS2_k127_3404410_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003343 246.0
TLS2_k127_3404410_1 oxidoreductase FAD NAD(P)-binding domain protein K00351,K18225 - 1.6.5.8 0.0000568 48.0
TLS2_k127_34075_0 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 478.0
TLS2_k127_34075_1 - - - - 0.0000000000000002691 80.0
TLS2_k127_3414985_0 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002001 258.0
TLS2_k127_3418385_0 Belongs to the amidase family K01426 - 3.5.1.4 1.337e-251 785.0
TLS2_k127_3418385_1 formate dehydrogenase (NAD+) activity K00123,K05299 - 1.17.1.10,1.17.1.9 1.229e-220 715.0
TLS2_k127_3418385_10 - - - - 0.0000000000000000000000000000000000000000000000000001027 201.0
TLS2_k127_3418385_11 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000001688 168.0
TLS2_k127_3418385_12 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000708 128.0
TLS2_k127_3418385_13 nucleotidyltransferase activity K17882 - - 0.00000000000000000000000000286 116.0
TLS2_k127_3418385_2 Periplasmic binding protein domain K01999 - - 1.113e-201 634.0
TLS2_k127_3418385_3 Domain of unknown function (DUF4118) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007206 446.0
TLS2_k127_3418385_4 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006247 410.0
TLS2_k127_3418385_5 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 369.0
TLS2_k127_3418385_6 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335,K18331 - 1.12.1.3,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 387.0
TLS2_k127_3418385_7 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004239 328.0
TLS2_k127_3418385_8 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 317.0
TLS2_k127_3418385_9 (ABC) transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001466 269.0
TLS2_k127_3451501_0 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000002137 221.0
TLS2_k127_3451501_1 membrane transporter protein K07090 - - 0.0000000000004056 73.0
TLS2_k127_347260_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337,K05572 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 359.0
TLS2_k127_347260_1 4Fe-4S dicluster domain K00338,K02573,K03941 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000005356 140.0
TLS2_k127_349766_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009456 560.0
TLS2_k127_349766_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 379.0
TLS2_k127_349766_2 Polyprenyl synthetase K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007498 334.0
TLS2_k127_349766_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000005947 74.0
TLS2_k127_349766_4 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000001265 64.0
TLS2_k127_349766_5 transferase activity, transferring glycosyl groups - - - 0.0000003041 63.0
TLS2_k127_349766_6 cell cycle K05589,K13052 - - 0.0001209 55.0
TLS2_k127_3498977_0 carbamoyl transferase, NodU family K00612,K16035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007723 356.0
TLS2_k127_3498977_1 PFAM DUF218 domain - - - 0.000000000001043 74.0
TLS2_k127_3509754_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000001161 144.0
TLS2_k127_3521064_0 symporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000008754 244.0
TLS2_k127_3523233_0 Sir2 family K12410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008094 286.0
TLS2_k127_3523233_1 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01577,K01652,K03852 - 2.2.1.6,2.3.3.15,4.1.1.8 0.00000000000000000000000000000000000000000000000000002576 194.0
TLS2_k127_3523233_2 - - - - 0.0000000000000000000000000000000009626 135.0
TLS2_k127_3523233_3 Acetyltransferase (GNAT) domain K03824 - - 0.00000000000000000000000000000006804 132.0
TLS2_k127_3523233_4 Belongs to the 'phage' integrase family - - - 0.00000000377 70.0
TLS2_k127_3523233_5 Integrase core domain - - - 0.000002652 56.0
TLS2_k127_353017_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008461 343.0
TLS2_k127_353017_1 gag-polyprotein putative aspartyl protease - - - 0.0000000000000000000007465 106.0
TLS2_k127_353017_2 - - - - 0.0000000003406 71.0
TLS2_k127_3540357_0 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 574.0
TLS2_k127_354193_0 Amidase K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 496.0
TLS2_k127_354193_1 alcohol dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009978 378.0
TLS2_k127_354193_2 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000003798 211.0
TLS2_k127_354193_3 PFAM Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000000000000000006742 179.0
TLS2_k127_354193_4 Protein conserved in bacteria - - - 0.000000000000000000000000000000001765 136.0
TLS2_k127_3578243_0 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 593.0
TLS2_k127_3578243_1 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000000005035 167.0
TLS2_k127_3619043_0 FAD dependent oxidoreductase - - - 0.0 1042.0
TLS2_k127_3619043_1 Belongs to the D-glutamate cyclase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 373.0
TLS2_k127_3619043_2 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.0000000000000000000000000000000000000000000000000000000000000000000000000006051 270.0
TLS2_k127_3619043_3 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000004823 220.0
TLS2_k127_3619043_4 Phosphotriesterase family K07048 - - 0.00000000000000000009195 90.0
TLS2_k127_36311_0 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 299.0
TLS2_k127_36311_1 Belongs to the TPP enzyme family K00156 - 1.2.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000147 273.0
TLS2_k127_36311_2 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008144 273.0
TLS2_k127_36311_3 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003309 265.0
TLS2_k127_36311_4 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001739 264.0
TLS2_k127_36311_5 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007584 259.0
TLS2_k127_36311_6 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000017 141.0
TLS2_k127_3647488_0 Baseplate J-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 435.0
TLS2_k127_3647488_1 Baseplate J-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 327.0
TLS2_k127_3647488_3 Tail protein - - - 0.00000001616 68.0
TLS2_k127_3747041_0 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000554 251.0
TLS2_k127_3747041_1 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01537 - 3.6.3.8 0.000000000000000000000000001229 126.0
TLS2_k127_3747041_2 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.0000000000000000000001615 98.0
TLS2_k127_3749501_0 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009639 350.0
TLS2_k127_3749501_1 DUF218 domain - - - 0.00000000000004851 82.0
TLS2_k127_3749501_2 Thioesterase-like superfamily - - - 0.00002795 50.0
TLS2_k127_3749692_0 benzoyl-CoA oxygenase - - - 2.413e-231 730.0
TLS2_k127_3749692_1 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000001961 216.0
TLS2_k127_3749692_2 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - - 0.000000003145 70.0
TLS2_k127_3749976_0 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 336.0
TLS2_k127_3749976_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000002635 199.0
TLS2_k127_3749976_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000001083 96.0
TLS2_k127_3749976_3 Sporulation related domain K03749 - - 0.00000008219 62.0
TLS2_k127_3750245_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 366.0
TLS2_k127_3750245_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000004124 214.0
TLS2_k127_3750245_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000004356 192.0
TLS2_k127_3750245_3 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000000106 183.0
TLS2_k127_3750533_0 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004294 337.0
TLS2_k127_3750533_1 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000623 314.0
TLS2_k127_3750533_2 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008881 317.0
TLS2_k127_3750533_3 PFAM Asp Glu hydantoin racemase K01799 - 5.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000007793 258.0
TLS2_k127_3750533_4 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000003544 237.0
TLS2_k127_3750533_5 intermembrane phospholipid transfer K07323 - - 0.0000000000000000000000000000000000000000000000000000007441 198.0
TLS2_k127_3750533_6 PFAM Mammalian cell entry related domain protein K02067 - - 0.000000000000000000000000000000000000000001145 163.0
TLS2_k127_3750533_7 - - - - 0.0000000000000000008825 94.0
TLS2_k127_3750533_8 - - - - 0.00002915 56.0
TLS2_k127_3750533_9 NADH dehydrogenase K03885 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.99.3 0.00007059 52.0
TLS2_k127_3752238_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009812 518.0
TLS2_k127_3752238_1 peptidase, M20 - - - 0.000000000000000000000000000000000000000000000000002547 188.0
TLS2_k127_3755064_0 Hydrogenase formation hypA family K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 524.0
TLS2_k127_3755064_1 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 312.0
TLS2_k127_3755064_2 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000003495 225.0
TLS2_k127_3755064_3 PFAM regulatory protein, LysR - - - 0.00000000000000000000000000000000000000000000000003632 190.0
TLS2_k127_3755064_4 HupF/HypC family K04653 - - 0.00000000000000000000000002172 111.0
TLS2_k127_3755064_5 hydrogenase expression formation protein HypE K04655 - - 0.000007312 51.0
TLS2_k127_3755737_0 NiFe/NiFeSe hydrogenase small subunit C-terminal K06282 - 1.12.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006983 482.0
TLS2_k127_3755737_1 hydrogenase large subunit K06281 - 1.12.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009966 418.0
TLS2_k127_3755737_2 hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006649 417.0
TLS2_k127_3755737_3 - - - - 0.000000000008085 73.0
TLS2_k127_3755737_4 - - - - 0.00000000005237 72.0
TLS2_k127_3755737_5 - - - - 0.00000007902 63.0
TLS2_k127_3755737_6 - - - - 0.000001624 58.0
TLS2_k127_3755737_7 - - - - 0.000002243 56.0
TLS2_k127_3757068_0 phosphorelay sensor kinase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001947 271.0
TLS2_k127_3757068_1 CoA-transferase family III - - - 0.0000000000000000000000005491 108.0
TLS2_k127_3759556_0 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 7.487e-287 910.0
TLS2_k127_3761994_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 406.0
TLS2_k127_3761994_1 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.00000000000000000000000000000007592 125.0
TLS2_k127_3761994_2 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000004112 102.0
TLS2_k127_3765070_0 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00162,K11381 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000531 485.0
TLS2_k127_3765070_1 S-acyltransferase activity K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002932 452.0
TLS2_k127_3765070_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K00162,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000004585 133.0
TLS2_k127_3765070_3 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.00000000000000000000000629 109.0
TLS2_k127_3765070_4 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000006067 91.0
TLS2_k127_3766067_0 PFAM NAD dependent epimerase dehydratase family K01710,K01784 - 4.2.1.46,5.1.3.2 0.000000000000000000000000000000000000000000002934 172.0
TLS2_k127_3766067_1 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000697 151.0
TLS2_k127_3766067_2 Lrp/AsnC ligand binding domain - - - 0.0000000001359 67.0
TLS2_k127_3768933_0 Ribosomal protein S1 K02945,K03527,K07571 - 1.17.7.4 1.443e-210 671.0
TLS2_k127_3768933_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 454.0
TLS2_k127_3768933_10 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000001148 241.0
TLS2_k127_3768933_11 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000008043 239.0
TLS2_k127_3768933_12 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000007454 231.0
TLS2_k127_3768933_13 D,d-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000000000000000000198 220.0
TLS2_k127_3768933_14 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000008604 240.0
TLS2_k127_3768933_15 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000001558 219.0
TLS2_k127_3768933_16 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000002777 224.0
TLS2_k127_3768933_17 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000008918 214.0
TLS2_k127_3768933_18 transferase activity, transferring glycosyl groups K02844 - - 0.000000000000000000000000000000000000000000000000000000366 218.0
TLS2_k127_3768933_19 Scavenger mRNA decapping enzyme C-term binding K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000000368 191.0
TLS2_k127_3768933_2 tRNA synthetases class I (W and Y) K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 406.0
TLS2_k127_3768933_20 Cytidylate kinase K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000008582 206.0
TLS2_k127_3768933_21 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000001339 173.0
TLS2_k127_3768933_22 lipopolysaccharide heptosyltransferase K02841,K02843 - - 0.000000000000000000000000000000000000000000002815 182.0
TLS2_k127_3768933_23 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000002224 177.0
TLS2_k127_3768933_24 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000001827 165.0
TLS2_k127_3768933_25 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000005903 158.0
TLS2_k127_3768933_26 Protein of unknown function (DUF1009) K09949 - - 0.00000000000000000000000000000000000002477 154.0
TLS2_k127_3768933_27 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000005061 156.0
TLS2_k127_3768933_28 Domain of unknown function (DUF374) K09778 - - 0.000000000000000000000000000000000007887 145.0
TLS2_k127_3768933_29 regulation of translation K05788 - - 0.00000000000000000000000000000005088 128.0
TLS2_k127_3768933_3 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008258 391.0
TLS2_k127_3768933_30 Glycosyltransferase Family 4 - - - 0.00000000000000000000000009534 124.0
TLS2_k127_3768933_31 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000002492 73.0
TLS2_k127_3768933_4 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 326.0
TLS2_k127_3768933_5 inositol 2-dehydrogenase activity K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 308.0
TLS2_k127_3768933_6 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 297.0
TLS2_k127_3768933_7 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000002888 282.0
TLS2_k127_3768933_8 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000176 266.0
TLS2_k127_3768933_9 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000009567 245.0
TLS2_k127_3772568_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004867 566.0
TLS2_k127_3772568_1 ATPases associated with a variety of cellular activities K05847 GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0031460,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337 - 0.0000000000000000000000000000000000000000000000000000000000000000000000003323 254.0
TLS2_k127_3772568_2 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.000000000000000002803 91.0
TLS2_k127_3776644_0 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001908 287.0
TLS2_k127_3776644_1 - - - - 0.000000000000001959 78.0
TLS2_k127_3776644_2 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0000000000008409 68.0
TLS2_k127_3776644_3 PFAM Major Facilitator Superfamily - - - 0.000000000004264 76.0
TLS2_k127_3776644_4 - - - - 0.0000005522 59.0
TLS2_k127_3779245_0 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 308.0
TLS2_k127_3779245_1 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000003942 236.0
TLS2_k127_3779453_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 1.105e-205 646.0
TLS2_k127_3779453_1 Pterin binding enzyme K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000001218 224.0
TLS2_k127_3779453_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000000000000000000000000000003024 143.0
TLS2_k127_3779802_0 AMP-binding enzyme K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004098 473.0
TLS2_k127_3779802_1 Histidine kinase - - - 0.0000000000000000000000000000000000000003908 163.0
TLS2_k127_3781162_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000681 361.0
TLS2_k127_3781162_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K03438,K13292 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 329.0
TLS2_k127_3781162_2 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.00000000000000000000000000000000000000000000000000000000000000000000000001069 278.0
TLS2_k127_3781162_3 MotA/TolQ/ExbB proton channel family K03562 - - 0.00000000000000000000000000000000000000000000003544 179.0
TLS2_k127_3781162_4 tRNA 3'-trailer cleavage K00784 - 3.1.26.11 0.000000000000000000000000000000000001295 149.0
TLS2_k127_3781162_5 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000003686 140.0
TLS2_k127_3781162_6 Biopolymer transport protein ExbD/TolR K03560 - - 0.0000000000000000000000000000005555 129.0
TLS2_k127_3781162_7 Ribulose-phosphate 3-epimerase K01783 - 5.1.3.1 0.000000000000000003133 88.0
TLS2_k127_3781162_8 DNA methylase K00590 - 2.1.1.113 0.000000000000001973 86.0
TLS2_k127_3781162_9 TonB C terminal K03646,K03832 - - 0.000001588 60.0
TLS2_k127_3783954_0 Adenylate and Guanylate cyclase catalytic domain - - - 2.947e-197 634.0
TLS2_k127_3785175_0 Adenylate and Guanylate cyclase catalytic domain - - - 3.882e-282 902.0
TLS2_k127_3787921_0 Subtilase family K08651,K14645 - 3.4.21.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 373.0
TLS2_k127_3787921_1 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000000000000000000000001246 188.0
TLS2_k127_3796923_0 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 570.0
TLS2_k127_3796923_1 Tripartite tricarboxylate transporter TctA family K07793 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 473.0
TLS2_k127_3796923_2 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 421.0
TLS2_k127_3796923_3 Tripartite tricarboxylate transporter family receptor K07795 - - 0.00000000000000000000000000000000000000000000000001762 193.0
TLS2_k127_3796923_4 COG4665 TRAP-type mannitol chloroaromatic compound transport system small permease component - - - 0.000000000000000000000000000000000000000000000002683 179.0
TLS2_k127_3796923_5 PFAM HEPN domain - - - 0.000000000000000000000000001452 119.0
TLS2_k127_3796923_6 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000002526 94.0
TLS2_k127_379918_0 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 390.0
TLS2_k127_379918_1 PFAM Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000925 237.0
TLS2_k127_379918_2 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000003823 149.0
TLS2_k127_3799328_0 HypF finger K04656 - - 1.236e-293 926.0
TLS2_k127_3799328_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 396.0
TLS2_k127_3799328_10 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000000000003405 108.0
TLS2_k127_3799328_11 Pyridoxamine 5'-phosphate oxidase - - - 0.000002425 55.0
TLS2_k127_3799328_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 344.0
TLS2_k127_3799328_3 Hydrogenase K04652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007318 335.0
TLS2_k127_3799328_4 Uracil DNA glycosylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001074 248.0
TLS2_k127_3799328_5 nickel cation binding K04651 - - 0.00000000000000000000000000000000000000001972 156.0
TLS2_k127_3799328_6 RES - - - 0.0000000000000000000000000000000001351 141.0
TLS2_k127_3799328_7 Protein of unknown function (DUF2384) - - - 0.000000000000000000000000000000001114 140.0
TLS2_k127_3799328_8 2-hydroxychromene-2-carboxylate isomerase - - - 0.000000000000000000000000000001241 132.0
TLS2_k127_3799328_9 - K00456 - 1.13.11.20 0.0000000000000000000000002608 120.0
TLS2_k127_3803269_0 protein conserved in cyanobacteria - - - 0.00000000000000000000000000000000000000004213 158.0
TLS2_k127_3803269_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01464,K01465 - 3.5.2.2,3.5.2.3 0.000000000000000000000000000000000002035 143.0
TLS2_k127_3803381_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1270.0
TLS2_k127_3803381_1 4Fe-4S binding domain K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 432.0
TLS2_k127_3803381_2 Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 305.0
TLS2_k127_3803381_3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007761 282.0
TLS2_k127_3803381_4 Protein involved in formate dehydrogenase formation K02380 - - 0.00000000000000000000000000000000000000000000000000000009814 209.0
TLS2_k127_3803381_5 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000002915 200.0
TLS2_k127_3803381_6 - - - - 0.0000000000000000000000000000563 125.0
TLS2_k127_3803381_7 PFAM ring hydroxylating dioxygenase, alpha subunit K16319 - 1.14.12.1 0.000000005289 66.0
TLS2_k127_3803381_8 Domain of Unknown Function (DUF748) - - - 0.000001882 62.0
TLS2_k127_3803381_9 - - - - 0.0001875 53.0
TLS2_k127_3803597_0 Amidohydrolase family - - - 9.745e-247 770.0
TLS2_k127_3803597_1 PFAM luciferase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 397.0
TLS2_k127_3803597_2 Coenzyme A transferase K01039 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009351 362.0
TLS2_k127_3803597_3 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 346.0
TLS2_k127_3803597_4 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 323.0
TLS2_k127_3803597_5 PFAM Coenzyme A transferase K01040 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004737 290.0
TLS2_k127_3803597_6 LamB/YcsF family K07160 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002931 265.0
TLS2_k127_3803597_7 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000414 185.0
TLS2_k127_3804889_0 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 449.0
TLS2_k127_3804939_0 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001727 256.0
TLS2_k127_3804939_1 reductase K00068,K03366 - 1.1.1.140,1.1.1.304,1.1.1.76 0.000000000000000000000000000000000000000000000000000000308 207.0
TLS2_k127_3804939_2 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000001575 178.0
TLS2_k127_3804939_3 COG1651 Protein-disulfide isomerase K21990 - - 0.000000000000000000000000000000000001389 147.0
TLS2_k127_38052_0 PFAM RNA binding S1 domain protein K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008586 337.0
TLS2_k127_38052_1 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000294 243.0
TLS2_k127_38052_2 Glucose / Sorbosone dehydrogenase K21430 - - 0.0000000000000000000001243 112.0
TLS2_k127_38052_3 RibD C-terminal domain K00082 - 1.1.1.193 0.00000000000383 78.0
TLS2_k127_3809967_0 Creatinase/Prolidase N-terminal domain K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000553 286.0
TLS2_k127_3809967_1 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - 0.00000000000000000000000000000000000000000000000000000000000000002361 228.0
TLS2_k127_3809967_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.000000000000000000000000005579 116.0
TLS2_k127_3812517_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008556 516.0
TLS2_k127_3812517_1 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000002476 177.0
TLS2_k127_3812517_2 4-hydroxyphenylacetate 3-hydroxylase C terminal K00483 - 1.14.14.9 0.0000000000000000000000000000000000002153 144.0
TLS2_k127_3818398_0 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005843 529.0
TLS2_k127_3818398_1 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 451.0
TLS2_k127_3818398_2 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005221 367.0
TLS2_k127_3818398_3 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008874,GO:0008875,GO:0016491,GO:0016614,GO:0016616,GO:0036094,GO:0042802,GO:0042803,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.1.1.69 0.00000000000000000000000000000000000000000000000000001018 199.0
TLS2_k127_3818398_4 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000001549 110.0
TLS2_k127_3818398_5 Binding-protein-dependent transport system inner membrane component K02054 - - 0.00003125 52.0
TLS2_k127_3818431_0 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007563 286.0
TLS2_k127_3818431_1 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.00000000000000000000000000000000000000000000000000000002535 198.0
TLS2_k127_3818431_2 Major Facilitator Superfamily - - - 0.000000000000000000001545 105.0
TLS2_k127_3818431_3 PFAM Cytidine and deoxycytidylate deaminase zinc-binding region - - - 0.000000000000000001038 100.0
TLS2_k127_381989_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004338 381.0
TLS2_k127_381989_1 PFAM Cupin 2 conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000002904 184.0
TLS2_k127_381989_2 Histidine Phosphotransfer domain - - - 0.00000000000000000000000000000000000000001062 160.0
TLS2_k127_3835944_0 Hydantoinase/oxoprolinase N-terminal region K01469,K01473 - 3.5.2.14,3.5.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 416.0
TLS2_k127_3835944_1 Hydantoinase B/oxoprolinase - - - 0.000000000000000001619 100.0
TLS2_k127_3838039_0 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007587 276.0
TLS2_k127_3838039_1 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000912 249.0
TLS2_k127_3838039_2 Neurotransmitter-gated ion-channel ligand binding domain - - - 0.000000000000000000000000000000000000000000000000000000000003991 223.0
TLS2_k127_3838039_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000005613 178.0
TLS2_k127_3852473_0 Belongs to the amidase family K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008593 313.0
TLS2_k127_3852473_1 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000717 236.0
TLS2_k127_3852473_2 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000002698 89.0
TLS2_k127_3853080_0 NADH-quinone oxidoreductase chain L K00341,K05577 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 535.0
TLS2_k127_3853080_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 - 1.6.5.3 0.000000000000000000000000002622 121.0
TLS2_k127_3853080_2 Belongs to the complex I subunit 6 family K00339,K05578 - 1.6.5.3 0.000000000000000000000004797 107.0
TLS2_k127_3853080_3 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000005396 90.0
TLS2_k127_3853580_0 photosynthesis - - - 0.0000000000000000000000000000000000000000000000000000001432 199.0
TLS2_k127_3853580_1 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000005042 143.0
TLS2_k127_3853580_2 DNA polymerase type-B family K02336 - 2.7.7.7 0.000000001921 68.0
TLS2_k127_3858_0 Belongs to the aldehyde dehydrogenase family K00128,K00138 - 1.2.1.3 7.515e-200 635.0
TLS2_k127_3858_1 Molydopterin dinucleotide binding domain K07306,K07309,K07310,K08352 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009390,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0033797,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494 1.8.5.3,1.8.5.5,1.97.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 588.0
TLS2_k127_3858_2 Amidohydrolase family K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000000000000004685 222.0
TLS2_k127_3858_3 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000007433 207.0
TLS2_k127_3858_4 TIGRFAM thioredoxin K03671 - - 0.00000000000000000000000000002032 126.0
TLS2_k127_3858_5 PFAM regulatory protein, LysR K02019 - - 0.0000000000000003793 83.0
TLS2_k127_3859261_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 7.187e-225 707.0
TLS2_k127_3859261_1 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 6.141e-219 690.0
TLS2_k127_3863102_0 Two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 513.0
TLS2_k127_3863102_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003335 257.0
TLS2_k127_3863102_2 Belongs to the universal stress protein A family - - - 0.0000000000000000000000004885 112.0
TLS2_k127_3863102_3 CBS domain - - - 0.00000000000000000000007041 108.0
TLS2_k127_3863102_4 Xanthine dehydrogenase K03520 - 1.2.5.3 0.0000000000000000000008676 95.0
TLS2_k127_3863102_5 Belongs to the universal stress protein A family - - - 0.000000000000000000007437 98.0
TLS2_k127_3863102_6 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.9.3.1 0.0000000007036 69.0
TLS2_k127_3863102_7 PFAM CBS domain - - - 0.000000003283 65.0
TLS2_k127_3865798_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 439.0
TLS2_k127_3865798_1 Belongs to the peptidase M16 family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009465 407.0
TLS2_k127_3870901_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 417.0
TLS2_k127_3870901_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000006948 175.0
TLS2_k127_3876794_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007571 441.0
TLS2_k127_3876927_0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005497 347.0
TLS2_k127_3876927_1 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000000000000000000000001285 220.0
TLS2_k127_3876927_2 Bacitracin resistance protein BacA K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000005509 192.0
TLS2_k127_3876927_3 3-demethylubiquinone-9 3-O-methyltransferase activity K20444 - - 0.000000000000000000000000000000007066 135.0
TLS2_k127_3879197_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007096 270.0
TLS2_k127_3879197_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000005954 256.0
TLS2_k127_3879197_2 FAD binding domain - - - 0.000000001053 61.0
TLS2_k127_3881129_0 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003497 402.0
TLS2_k127_3881129_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005222 337.0
TLS2_k127_3881129_2 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000002763 248.0
TLS2_k127_3881129_3 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000004996 199.0
TLS2_k127_3881129_4 - - - - 0.00000000000000000000000000000000000000000001094 168.0
TLS2_k127_3881129_5 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000003394 156.0
TLS2_k127_3881129_6 dehydratase - - - 0.0000000000000000000000000000000000000001287 158.0
TLS2_k127_3881129_7 Acyl dehydratase - - - 0.0000000000000000000000000000000000000002163 162.0
TLS2_k127_3881129_8 amine dehydrogenase activity - - - 0.0000000000000000000000003743 107.0
TLS2_k127_3883291_0 Major facilitator Superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 378.0
TLS2_k127_3883291_1 TIGRFAM diguanylate cyclase (GGDEF) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007011 338.0
TLS2_k127_3883291_2 phosphatase activity - - - 0.000000000000000000000000000004988 132.0
TLS2_k127_3885202_0 Domain of Unknown Function (DUF748) - - - 0.000000000000000000000000004604 126.0
TLS2_k127_3885307_0 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002063 289.0
TLS2_k127_3885307_1 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000001168 203.0
TLS2_k127_3885307_2 Tetratricopeptide repeat - - - 0.0000000000000000000000006626 115.0
TLS2_k127_3885307_3 Putative regulatory protein - - - 0.0000000000000000005479 93.0
TLS2_k127_3885307_4 Peptidoglycan-synthase activator LpoB - - - 0.0000000611 63.0
TLS2_k127_3885307_5 - - - - 0.00005381 56.0
TLS2_k127_3887115_0 amidohydrolase K12941 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 542.0
TLS2_k127_3887115_1 Amidinotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 423.0
TLS2_k127_3887115_2 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.000000000000000000000000000000000000000000000000000002756 196.0
TLS2_k127_3888862_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 9.078e-282 899.0
TLS2_k127_3888862_1 PFAM type II secretion system protein E K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 379.0
TLS2_k127_3888862_2 Modulates RecA activity K03565 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000004585 66.0
TLS2_k127_389573_0 Belongs to the ABC transporter superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 498.0
TLS2_k127_389573_1 COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 470.0
TLS2_k127_389573_2 Threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 397.0
TLS2_k127_389573_3 COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 366.0
TLS2_k127_389573_4 PFAM ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009909 340.0
TLS2_k127_389573_5 Cupin superfamily (DUF985) K09705 - - 0.00000000000000000000000000000000000000000000000000000000007088 208.0
TLS2_k127_389573_6 MlaD protein K06192 - - 0.0000000000000000000000000000000000000000000000000001455 200.0
TLS2_k127_389573_7 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000003404 131.0
TLS2_k127_389573_8 ABC-type transport auxiliary lipoprotein component K09857 - - 0.0000000000000000000000000007817 129.0
TLS2_k127_3900320_0 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 360.0
TLS2_k127_3900320_1 LVIVD repeat - - - 0.000000000000000000000000000000000000000001513 158.0
TLS2_k127_3900320_2 Ketopantoate reductase PanE/ApbA C terminal - - - 0.000000000000003308 79.0
TLS2_k127_3902913_0 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 444.0
TLS2_k127_3902913_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768,K09565 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 0.00000000000000000000000000000002674 128.0
TLS2_k127_3902913_2 ATPase activity K02017 - 3.6.3.29 0.00000000000006543 78.0
TLS2_k127_3906655_0 Belongs to the TPP enzyme family K01576 - 4.1.1.7 1.591e-210 671.0
TLS2_k127_3906655_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000003583 164.0
TLS2_k127_3906655_2 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000001476 138.0
TLS2_k127_3920763_0 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000435 201.0
TLS2_k127_3920763_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K20023 - 4.2.1.156,4.2.1.42 0.000000002574 58.0
TLS2_k127_3921351_0 Gamma-glutamyltranspeptidase - - - 1.038e-211 685.0
TLS2_k127_3921351_1 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases large terminal subunit K16319,K18074 - 1.14.12.1,1.14.12.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 543.0
TLS2_k127_3921351_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 421.0
TLS2_k127_3921351_3 Mechanosensitive ion channel K16052,K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 413.0
TLS2_k127_3921351_4 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004708 269.0
TLS2_k127_3921351_5 Histidine phosphatase superfamily (branch 1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000008003 251.0
TLS2_k127_3921351_6 Phosphatidylinositol - - - 0.00000000000000000000000000000000000000000000000000000000000001848 240.0
TLS2_k127_3921351_7 Ring hydroxylating beta subunit K16320 - 1.14.12.1 0.00000000000000000000000000000000000000000000000000177 197.0
TLS2_k127_3921351_8 Protein of unknown function (DUF3090) - - - 0.00000000000000000000000000000000001022 141.0
TLS2_k127_392820_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004082 469.0
TLS2_k127_392820_1 PUA domain K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008765 379.0
TLS2_k127_392820_2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000001043 153.0
TLS2_k127_392820_3 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000005164 128.0
TLS2_k127_3932703_0 Putative modulator of DNA gyrase K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 610.0
TLS2_k127_3932703_1 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008411 378.0
TLS2_k127_3932703_2 Putative modulator of DNA gyrase K03592 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 290.0
TLS2_k127_3932703_3 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006684 263.0
TLS2_k127_3932703_4 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000002434 228.0
TLS2_k127_3932703_5 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000000000001113 187.0
TLS2_k127_3932703_6 With ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate K03154 - - 0.0000000000252 67.0
TLS2_k127_3933748_0 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003668 289.0
TLS2_k127_3933748_1 ABC-type sugar transport system, permease component K02026 - - 0.0000000000007562 72.0
TLS2_k127_3934811_0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005521 465.0
TLS2_k127_3934811_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001022 265.0
TLS2_k127_3938143_0 Alcohol dehydrogenase GroES-like domain K00055 - 1.1.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005011 508.0
TLS2_k127_3938143_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009031 259.0
TLS2_k127_3938905_0 PFAM phosphoesterase, RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 331.0
TLS2_k127_3938905_1 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003569 257.0
TLS2_k127_3938905_2 integral membrane protein - - - 0.0000006385 58.0
TLS2_k127_3939810_0 COG0463 Glycosyltransferases involved in cell wall biogenesis K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000001676 242.0
TLS2_k127_3939810_1 phosphatidylinositol metabolic process K13669,K13671 - - 0.0000002317 63.0
TLS2_k127_394407_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 417.0
TLS2_k127_394407_1 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 298.0
TLS2_k127_3950751_0 SNARE associated Golgi protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000003724 192.0
TLS2_k127_3950751_1 Tim44 K15539 - - 0.0000000000000000000000000000000000000000000000001021 179.0
TLS2_k127_3950751_2 Amidase - - - 0.0000000000000003431 79.0
TLS2_k127_395461_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 358.0
TLS2_k127_395461_1 MiaB-like tRNA modifying enzyme K18707 - 2.8.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003776 346.0
TLS2_k127_395461_2 PFAM PfkB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004972 272.0
TLS2_k127_395461_3 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.000000000000000000000000006288 111.0
TLS2_k127_3956509_0 Psort location Cytoplasmic, score K14731 - 3.1.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000003475 255.0
TLS2_k127_3956509_1 Low affinity iron permease - - - 0.0000000000000000000000000000000000000000000003979 179.0
TLS2_k127_3956657_0 Glycine reductase complex component B subunit gamma K10672 - 1.21.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007035 302.0
TLS2_k127_3956657_1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006082 282.0
TLS2_k127_3956657_2 PFAM Glycine sarcosine betaine reductase complex, protein B, alpha and beta subunits K10671 - 1.21.4.2 0.00000000000000000000000000000000000000000000000000000000003597 222.0
TLS2_k127_3956657_3 Selenoprotein B, glycine betaine sarcosine D-proline reductase family K10672 - 1.21.4.2 0.0000000000000000001623 91.0
TLS2_k127_3956657_4 InterPro IPR007367 - - - 0.000000000000000001269 94.0
TLS2_k127_3960555_0 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 509.0
TLS2_k127_3960555_1 PFAM Phosphomethylpyrimidine kinase type-1 K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 289.0
TLS2_k127_3960555_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000000000000000000000000000000000000000000000000000000000009737 244.0
TLS2_k127_3961111_0 Putative sugar-binding N-terminal domain K21948 - 2.7.1.217 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 512.0
TLS2_k127_3961111_1 Class II Aldolase and Adducin N-terminal domain K22130 - 4.1.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000000000005358 289.0
TLS2_k127_3961111_2 Putative PD-(D/E)XK phosphodiesterase (DUF2161) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001906 266.0
TLS2_k127_3961111_3 PFAM Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000002227 216.0
TLS2_k127_3961111_4 Polymer-forming cytoskeletal - - - 0.0000000000000000001455 102.0
TLS2_k127_3969628_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16,6.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 530.0
TLS2_k127_3969628_1 KaiC K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006508 512.0
TLS2_k127_3969628_10 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000001451 231.0
TLS2_k127_3969628_11 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000002139 211.0
TLS2_k127_3969628_12 Histidine biosynthesis bifunctional protein hisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000006671 192.0
TLS2_k127_3969628_13 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.00000000000000000000000000000000000000000000002743 179.0
TLS2_k127_3969628_14 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000185 181.0
TLS2_k127_3969628_15 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000002205 174.0
TLS2_k127_3969628_16 Binds the 23S rRNA K02909 - - 0.000000000000000001078 85.0
TLS2_k127_3969628_17 - - - - 0.000000000000001247 90.0
TLS2_k127_3969628_18 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000001169 72.0
TLS2_k127_3969628_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 431.0
TLS2_k127_3969628_3 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006832 429.0
TLS2_k127_3969628_4 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 354.0
TLS2_k127_3969628_5 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765,K02502 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000001655 259.0
TLS2_k127_3969628_6 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006359 249.0
TLS2_k127_3969628_7 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007301 242.0
TLS2_k127_3969628_8 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000009662 243.0
TLS2_k127_3969628_9 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000005735 228.0
TLS2_k127_3970815_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.423e-213 683.0
TLS2_k127_3970815_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 514.0
TLS2_k127_3970815_11 PFAM Haloacid dehalogenase domain protein hydrolase K07025 - - 0.0000000000000003354 86.0
TLS2_k127_3970815_12 Carrier of the growing fatty acid chain in fatty acid biosynthesis K21781 GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249 - 0.00000001901 64.0
TLS2_k127_3970815_13 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000001903 55.0
TLS2_k127_3970815_14 DinB family - - - 0.000002389 61.0
TLS2_k127_3970815_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 492.0
TLS2_k127_3970815_3 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749,K18702 - 2.8.3.16,2.8.3.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 316.0
TLS2_k127_3970815_4 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000007655 234.0
TLS2_k127_3970815_5 Putative serine dehydratase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001157 236.0
TLS2_k127_3970815_6 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.000000000000000000000000000000000000000000000000005005 190.0
TLS2_k127_3970815_7 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000001671 186.0
TLS2_k127_3970815_8 - - - - 0.00000000000000000000000000000000000003963 165.0
TLS2_k127_3970815_9 TPM domain - - - 0.00000000000000000000000000000008247 131.0
TLS2_k127_3971470_0 Belongs to the GPI family K01810 - 5.3.1.9 6.006e-278 875.0
TLS2_k127_3971470_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 561.0
TLS2_k127_3971470_10 GAF domain K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000112 198.0
TLS2_k127_3971470_11 dihydroorotate dehydrogenase activity K02823,K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000002576 184.0
TLS2_k127_3971470_12 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000005329 112.0
TLS2_k127_3971470_13 Tautomerase enzyme - - - 0.00000000002352 66.0
TLS2_k127_3971470_2 Transaldolase/Fructose-6-phosphate aldolase K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006287 518.0
TLS2_k127_3971470_3 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008473 310.0
TLS2_k127_3971470_4 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 299.0
TLS2_k127_3971470_5 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004158 309.0
TLS2_k127_3971470_6 Transcriptional regulator sugar kinase K00886 - 2.7.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000003951 285.0
TLS2_k127_3971470_7 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000001341 235.0
TLS2_k127_3971470_8 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000003654 224.0
TLS2_k127_3971470_9 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000463 207.0
TLS2_k127_3976429_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01835 - 5.4.2.2 3.202e-195 616.0
TLS2_k127_3976429_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 432.0
TLS2_k127_3976429_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 0.0000000000000000000000000000000002469 134.0
TLS2_k127_3978884_0 epimerase dehydratase K22025 - 1.1.1.410 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 464.0
TLS2_k127_3978884_1 TIGRFAM geranylgeranyl reductase K21401 - 1.3.99.38 0.0000000000000000000000000000000000000000000001886 175.0
TLS2_k127_3978884_2 Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000006737 104.0
TLS2_k127_3983099_0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase - - - 2.26e-312 980.0
TLS2_k127_3983099_1 hydrolase, family 65, central catalytic - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 481.0
TLS2_k127_3983099_2 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 294.0
TLS2_k127_3983099_3 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000009845 235.0
TLS2_k127_3983487_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 542.0
TLS2_k127_3983487_1 TIGRFAM riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000008299 181.0
TLS2_k127_3983487_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000004859 126.0
TLS2_k127_3983487_3 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000006421 78.0
TLS2_k127_3993592_0 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000218 283.0
TLS2_k127_3993592_1 Branched-chain amino acid transport system / permease component K01997 - - 0.00004129 48.0
TLS2_k127_3995014_0 Glycosyltransferase like family 2 K12992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002289 283.0
TLS2_k127_3995014_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000001231 229.0
TLS2_k127_3995014_2 glycosyl transferase family 2 K20444 - - 0.0000000000000000000000000000003962 143.0
TLS2_k127_4011885_0 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 9.742e-275 867.0
TLS2_k127_4013378_0 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 356.0
TLS2_k127_4013378_1 STAS domain K06378 - - 0.000000000000000004033 86.0
TLS2_k127_4013378_2 Tetratricopeptide repeat - - - 0.00000000000000004168 86.0
TLS2_k127_4014646_0 Glycosyl transferase, family 2 - - - 3.012e-218 694.0
TLS2_k127_4014646_1 PFAM ABC transporter, transmembrane region K06147,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 449.0
TLS2_k127_4017731_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 2.139e-238 745.0
TLS2_k127_4017731_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009027 287.0
TLS2_k127_4022342_0 Memo-like protein K06990 - - 0.0000000000000000000000000000000000000004642 159.0
TLS2_k127_4027012_0 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002763 550.0
TLS2_k127_4027152_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 2.83e-198 628.0
TLS2_k127_4027152_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 469.0
TLS2_k127_4027152_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 358.0
TLS2_k127_4027152_3 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000005611 253.0
TLS2_k127_4027152_4 DNA polymerase alpha chain like domain K07053,K20859 - 3.1.3.97,3.1.4.57 0.00000000000000000000000000000000000000000000000000000000000000000000004641 252.0
TLS2_k127_4027152_5 Lipoate-protein ligase K03800 - 6.3.1.20 0.0000000000000000000000000000000000000000000001222 181.0
TLS2_k127_4027152_6 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate K02437 - - 0.00000000000000000000000000000000000000005306 166.0
TLS2_k127_4027152_7 NUDIX domain K01515,K03574 - 3.6.1.13,3.6.1.55 0.0000000000000000000000000000000007753 138.0
TLS2_k127_4027152_8 Thioesterase superfamily - - - 0.00002989 55.0
TLS2_k127_4027536_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008255 519.0
TLS2_k127_4027536_1 inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 413.0
TLS2_k127_4027536_2 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 311.0
TLS2_k127_4027536_3 - - - - 0.00000000000000000000000000000000106 136.0
TLS2_k127_4027536_4 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.00000000000000000000000000002235 119.0
TLS2_k127_4027536_5 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000741 114.0
TLS2_k127_4034340_0 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 525.0
TLS2_k127_4034340_1 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 437.0
TLS2_k127_4034340_10 PFAM ATP-binding region, ATPase domain protein K02482 - 2.7.13.3 0.0000000000000000000000000000000000000009359 166.0
TLS2_k127_4034340_11 regulation of translation K03530 - - 0.0000000000000000000000000000002241 126.0
TLS2_k127_4034340_12 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000000000000000000000000000006135 138.0
TLS2_k127_4034340_13 PFAM pyridoxamine 5'-phosphate oxidase-related - - - 0.000000000000000000000000000004773 129.0
TLS2_k127_4034340_14 Bacterial regulatory protein, Fis family K07715 - - 0.00000000000000000000000005326 123.0
TLS2_k127_4034340_15 redox protein regulator of disulfide bond formation - - - 0.00000009584 54.0
TLS2_k127_4034340_2 PFAM sigma-54 factor interaction domain-containing protein K02481,K07714,K10943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 354.0
TLS2_k127_4034340_3 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 334.0
TLS2_k127_4034340_4 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006391 279.0
TLS2_k127_4034340_5 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007274 282.0
TLS2_k127_4034340_6 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000003821 235.0
TLS2_k127_4034340_7 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000007417 192.0
TLS2_k127_4034340_8 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000001973 186.0
TLS2_k127_4034340_9 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.000000000000000000000000000000000000000000004592 183.0
TLS2_k127_4036862_0 MmgE PrpD family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 294.0
TLS2_k127_4036862_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000047 253.0
TLS2_k127_4036862_2 Ketopantoate reductase PanE/ApbA C terminal - - - 0.00000000000000000001652 94.0
TLS2_k127_4047922_0 Drug exporters of the RND superfamily K06994 - - 1.147e-205 659.0
TLS2_k127_4047922_1 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.0000000000000000006906 89.0
TLS2_k127_4062041_0 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 539.0
TLS2_k127_4062041_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 466.0
TLS2_k127_4062041_2 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 443.0
TLS2_k127_4062041_3 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 327.0
TLS2_k127_4062041_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000001545 205.0
TLS2_k127_4063335_0 N-terminal TM domain of oligopeptide transport permease C K15582 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 385.0
TLS2_k127_4063335_1 PFAM binding-protein-dependent transport systems inner membrane component K02033,K15581 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007798 289.0
TLS2_k127_4063335_2 PFAM extracellular solute-binding protein family 5 K02035 - - 0.00000008982 64.0
TLS2_k127_4063335_3 Domain of unknown function (DUF4445) K04755,K08952,K08953,K08954 GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858 - 0.0003547 46.0
TLS2_k127_4064018_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 2.081e-300 975.0
TLS2_k127_4064018_1 synthase K00705,K06044 GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 5.909e-277 884.0
TLS2_k127_4064018_10 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 387.0
TLS2_k127_4064018_11 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005164 365.0
TLS2_k127_4064018_12 PFAM Glycosyl transferases group 1 K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006267 350.0
TLS2_k127_4064018_13 Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008016 293.0
TLS2_k127_4064018_14 Proteasome subunit K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005178 314.0
TLS2_k127_4064018_15 Proteasome subunit K03432 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002867 280.0
TLS2_k127_4064018_16 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001854 263.0
TLS2_k127_4064018_17 PFAM Stage II sporulation K06381 - - 0.0000000000000000000000000000000000000000000000000000003942 209.0
TLS2_k127_4064018_18 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000005533 183.0
TLS2_k127_4064018_19 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000004681 188.0
TLS2_k127_4064018_2 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.08e-268 848.0
TLS2_k127_4064018_20 Putative tRNA binding domain K06878 - - 0.000000000000000000000000000000001599 147.0
TLS2_k127_4064018_21 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.00000000000000000000000000000004624 132.0
TLS2_k127_4064018_22 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000001865 128.0
TLS2_k127_4064018_23 Acyl-CoA hydrolase K01073 - 3.1.2.20 0.000000000000000000000000001256 131.0
TLS2_k127_4064018_24 protein transport K03210 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000005552 106.0
TLS2_k127_4064018_25 Protein of unknown function (DUF2905) - - - 0.0000000000000000007465 92.0
TLS2_k127_4064018_26 glycosyl transferase family 2 K21349 - 2.4.1.268 0.000000000000004696 84.0
TLS2_k127_4064018_3 Proteasomal ATPase OB/ID domain K07184,K07777,K12065,K13525,K13527 GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 2.7.13.3 2.943e-232 734.0
TLS2_k127_4064018_4 Alpha amylase, catalytic domain K01236 - 3.2.1.141 1.995e-202 673.0
TLS2_k127_4064018_5 Pup-ligase protein K20814 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 583.0
TLS2_k127_4064018_6 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K13571 GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 575.0
TLS2_k127_4064018_7 Protein export membrane protein K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 506.0
TLS2_k127_4064018_8 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 415.0
TLS2_k127_4064018_9 Starch synthase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 393.0
TLS2_k127_4067345_0 peptide deformylase activity K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000004056 216.0
TLS2_k127_4067345_1 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000005346 181.0
TLS2_k127_4071255_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 511.0
TLS2_k127_4071255_1 Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon K03709 - - 0.000000000000000000000000000000000000000000006598 175.0
TLS2_k127_4071255_2 Metallo-beta-lactamase superfamily K13075 - 3.1.1.81 0.0000000000000000000000000000000000000002043 166.0
TLS2_k127_4071255_3 Uncharacterized ACR, COG1430 K09005 - - 0.000000003347 62.0
TLS2_k127_4073156_0 Luciferase-like monooxygenase - - - 6.842e-208 653.0
TLS2_k127_4073156_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000001562 235.0
TLS2_k127_4073156_2 membrane K02451,K03832 - - 0.0000000008783 70.0
TLS2_k127_407331_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003838 433.0
TLS2_k127_407331_1 Lysine methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000003779 228.0
TLS2_k127_4079737_0 binding-protein-dependent transport systems inner membrane component K02054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009615 250.0
TLS2_k127_4079737_1 Binding-protein-dependent transport system inner membrane component K02053 - - 0.000000000000000000000000000000000000000001917 174.0
TLS2_k127_40858_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1268.0
TLS2_k127_40858_1 Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 494.0
TLS2_k127_40858_10 PFAM PfkB domain protein - - - 0.0000000000000000000000000000000000000000007914 168.0
TLS2_k127_40858_11 Cyclophilin-like K09143 - - 0.00000000000000000000000000000000002134 142.0
TLS2_k127_40858_12 Metal binding domain of Ada K00567 - 2.1.1.63 0.00000000000000000000000000000000004669 150.0
TLS2_k127_40858_13 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.00000000000000000000000006246 117.0
TLS2_k127_40858_14 DinB superfamily - - - 0.0000000000000000000000002602 117.0
TLS2_k127_40858_15 MFS_1 like family - - - 0.00000000000000000000001249 118.0
TLS2_k127_40858_16 MaoC like domain - - - 0.00000000000000000003414 99.0
TLS2_k127_40858_17 Periplasmic binding protein - - - 0.0000000000007607 68.0
TLS2_k127_40858_18 dehydratase - - - 0.000008445 59.0
TLS2_k127_40858_2 Pyruvate kinase K00873 GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 430.0
TLS2_k127_40858_3 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 400.0
TLS2_k127_40858_4 PFAM AMP-dependent synthetase and ligase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000319 380.0
TLS2_k127_40858_5 Oxygenase, catalysing oxidative methylation of damaged DNA K09990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 302.0
TLS2_k127_40858_6 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007573 284.0
TLS2_k127_40858_7 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000003104 276.0
TLS2_k127_40858_8 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000007205 237.0
TLS2_k127_40858_9 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000001944 204.0
TLS2_k127_4088176_0 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004276 364.0
TLS2_k127_4088176_1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 2.5.1.120,2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 342.0
TLS2_k127_4088176_2 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007706 275.0
TLS2_k127_4088176_3 YsiA-like protein, C-terminal region K13770 - - 0.00000000000000000000000000000000000000000005807 168.0
TLS2_k127_4088176_4 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000002652 136.0
TLS2_k127_4088176_5 PHP domain protein K07053 - 3.1.3.97 0.0001659 51.0
TLS2_k127_4096459_0 ABC transporter transmembrane region K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009817 564.0
TLS2_k127_4096459_1 tRNA rRNA methyltransferase (SpoU) - - - 0.000000000000000000000000000000000000000000000000000000001764 210.0
TLS2_k127_4096459_2 Luciferase-like monooxygenase K00320,K14728 - 1.5.98.2 0.00000000000000000000000000000000000000000009127 173.0
TLS2_k127_4142376_0 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 457.0
TLS2_k127_4142376_1 Histidine kinase-like ATPase domain - - - 0.0000000000000002962 82.0
TLS2_k127_4157229_0 Hydantoinase B/oxoprolinase - - - 1.099e-211 676.0
TLS2_k127_4157229_1 Hydantoinase/oxoprolinase K01469,K01473 - 3.5.2.14,3.5.2.9 0.000000000000000000000000000000000000000000000000000004334 196.0
TLS2_k127_4165720_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000007277 239.0
TLS2_k127_4165720_1 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000005951 175.0
TLS2_k127_4176831_0 Maleate cis-trans isomerase K01799 - 5.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007166 294.0
TLS2_k127_4176831_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000008436 220.0
TLS2_k127_4176831_2 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000001222 194.0
TLS2_k127_4176831_3 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000003364 142.0
TLS2_k127_4178545_0 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 497.0
TLS2_k127_4178545_1 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000009062 138.0
TLS2_k127_4181548_0 E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 290.0
TLS2_k127_4181548_1 Amidohydrolase family - - - 0.000000000000000000002561 93.0
TLS2_k127_4186085_0 Class II Aldolase and Adducin N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009748 284.0
TLS2_k127_4186085_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781 - 5.1.2.2 0.000000000000000000000000000000000000000000000000000002568 207.0
TLS2_k127_4193464_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 597.0
TLS2_k127_4193464_1 Histidine kinase K01768,K07315 - 3.1.3.3,4.6.1.1 0.000004329 57.0
TLS2_k127_4207884_0 Universal stress protein UspA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000365 256.0
TLS2_k127_4207884_1 CBS domain - - - 0.000000000000000000000000000000000000000000000001922 181.0
TLS2_k127_4207884_2 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit K00162 - 1.2.4.1 0.00005449 52.0
TLS2_k127_4220996_0 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 373.0
TLS2_k127_4220996_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001858 281.0
TLS2_k127_422263_0 COG4177 ABC-type branched-chain amino acid transport system, permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002165 286.0
TLS2_k127_422263_1 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004196 271.0
TLS2_k127_422263_2 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000004101 106.0
TLS2_k127_4233553_0 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.0000000000000000000000000000000000000000000000000000000000001038 222.0
TLS2_k127_4233553_1 Hydrolase - - - 0.0000000000000000000000007722 111.0
TLS2_k127_4255648_0 NUDIX domain - - - 0.00000000000000000000000000000000002552 139.0
TLS2_k127_4255648_1 Belongs to the ompA family - - - 0.00000000000002371 85.0
TLS2_k127_4255648_3 PFAM FecR protein - - - 0.00002336 54.0
TLS2_k127_4271106_0 Hydantoinase B/oxoprolinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009998 590.0
TLS2_k127_4271106_1 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 497.0
TLS2_k127_4271106_2 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000001271 219.0
TLS2_k127_4271106_3 Extracellular liganD-binding receptor K01999 - - 0.000000000000000000000000000000000000000001346 171.0
TLS2_k127_4271106_4 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000509 137.0
TLS2_k127_4271668_0 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 409.0
TLS2_k127_4271668_1 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002781 284.0
TLS2_k127_4271668_2 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008819 278.0
TLS2_k127_4271668_3 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001861 282.0
TLS2_k127_4271668_4 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000006245 239.0
TLS2_k127_4271668_5 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000001072 96.0
TLS2_k127_4307074_0 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000001321 238.0
TLS2_k127_4307074_1 cob(I)yrinic acid a,c-diamide adenosyltransferase activity K00798,K13821 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.2.1.88,1.5.5.2,2.5.1.17 0.00000000000000000000000000000000000000000000000000000000001987 212.0
TLS2_k127_4307074_2 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000000000000003674 208.0
TLS2_k127_4307074_3 Belongs to the TPP enzyme family K01576 - 4.1.1.7 0.0000000000000000000000000000000000008664 145.0
TLS2_k127_4307403_0 Wax ester synthase-like Acyl-CoA acyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000159 258.0
TLS2_k127_4307403_1 AMP-binding enzyme C-terminal domain - - - 0.000000002038 59.0
TLS2_k127_4307403_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000007055 66.0
TLS2_k127_4307403_3 alpha/beta hydrolase fold - - - 0.0000000243 59.0
TLS2_k127_4309603_0 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000001282 185.0
TLS2_k127_4309603_1 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000001354 170.0
TLS2_k127_4309603_2 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.0000000000000000000000004654 113.0
TLS2_k127_4312692_0 Putative metal-binding domain of cation transport ATPase K01533 - 3.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 329.0
TLS2_k127_4312692_1 Cytochrome oxidase maturation protein cbb3-type - - - 0.0000006171 62.0
TLS2_k127_4320343_0 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001452 280.0
TLS2_k127_4320343_1 LPXTG cell wall anchor motif - - - 0.0001328 53.0
TLS2_k127_4327410_0 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 1.1e-267 835.0
TLS2_k127_4327410_1 YCII-related domain - - - 0.0000000000000000000000000000172 120.0
TLS2_k127_4327477_0 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.00000000000000000000000000000000000000000000001346 193.0
TLS2_k127_4327477_1 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000005926 136.0
TLS2_k127_4327477_2 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000164 109.0
TLS2_k127_4343707_0 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 352.0
TLS2_k127_4343707_1 PFAM Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000002719 271.0
TLS2_k127_4343707_2 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000008739 127.0
TLS2_k127_4364957_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 443.0
TLS2_k127_4364957_1 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 388.0
TLS2_k127_4364957_2 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 332.0
TLS2_k127_4364957_3 SUF system FeS assembly protein, NifU family K04488 - - 0.000000000000000000000000295 111.0
TLS2_k127_4364957_4 prohibitin homologues - - - 0.0000000000000001889 92.0
TLS2_k127_4387969_0 Transglycosylase K05366 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000313 563.0
TLS2_k127_4387969_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 470.0
TLS2_k127_4432071_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 3.02e-242 757.0
TLS2_k127_4432071_1 PFAM Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 1.797e-232 733.0
TLS2_k127_4432071_2 Evidence 5 No homology to any previously reported sequences K03765 - - 0.000000000000003322 84.0
TLS2_k127_4469034_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 3.051e-204 648.0
TLS2_k127_4469034_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005967 265.0
TLS2_k127_4469034_2 Predicted integral membrane protein (DUF2282) - - - 0.0000000000000000003501 96.0
TLS2_k127_4508377_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000001938 229.0
TLS2_k127_4508377_1 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.00000000000000000000000000000000000000000000000000001887 197.0
TLS2_k127_4508377_2 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000001043 203.0
TLS2_k127_4508377_3 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.000000002863 58.0
TLS2_k127_45094_0 Carboxyl transferase domain - - - 6.206e-236 744.0
TLS2_k127_45094_1 non-haem dioxygenase in morphine synthesis N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000115 254.0
TLS2_k127_45094_2 Metallo-beta-lactamase superfamily K13075 - 3.1.1.81 0.00000000000000000000000000000000000000000000000000000000001199 215.0
TLS2_k127_45094_3 - K09143 - - 0.0000000000000000000000000000000000000000000000000000001287 199.0
TLS2_k127_464109_0 PFAM peptidase S58, DmpA K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000006261 262.0
TLS2_k127_464109_1 PFAM DoxX family protein K15977 - - 0.0000000000005869 78.0
TLS2_k127_4677240_0 Abc transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000001046 246.0
TLS2_k127_4677240_1 PFAM ABC transporter related K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000001014 233.0
TLS2_k127_4677240_2 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.0000000000001773 73.0
TLS2_k127_4677240_3 Protein synonym hydantoin utilization protein A K01473 - 3.5.2.14 0.00000001842 56.0
TLS2_k127_4678722_0 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 313.0
TLS2_k127_4678722_1 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000001158 256.0
TLS2_k127_4678722_2 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000001771 258.0
TLS2_k127_4678722_3 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000001479 218.0
TLS2_k127_4679780_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 4.754e-260 809.0
TLS2_k127_4679780_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000003227 254.0
TLS2_k127_4679781_0 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.0 1090.0
TLS2_k127_4679781_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000001254 256.0
TLS2_k127_4679781_2 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008256 246.0
TLS2_k127_4679781_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 0.000000000000000000000000001068 113.0
TLS2_k127_468843_0 Hydrophobe amphiphile Efflux-1 (HAE1) family K03296,K18138 - - 1.685e-210 668.0
TLS2_k127_468843_1 Protein export membrane protein K03296,K18138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005204 387.0
TLS2_k127_4689236_0 transport system, permease component K13894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 544.0
TLS2_k127_4689236_1 transport system, permease component K13895 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 554.0
TLS2_k127_4689236_2 Belongs to the ABC transporter superfamily K13896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005306 363.0
TLS2_k127_4689236_3 COG4166 ABC-type oligopeptide transport system, periplasmic component K13893 - - 0.000000000000000000000000000000000000000000000000000000001886 202.0
TLS2_k127_4691659_0 Nitroreductase family K10678 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003363 345.0
TLS2_k127_4691659_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000002253 223.0
TLS2_k127_4691659_2 Phosphonate ABC transporter K02044 - - 0.000000000000000000000000000000000000000000000001325 186.0
TLS2_k127_4696243_0 involved in lipopolysaccharide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 495.0
TLS2_k127_4696243_1 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 412.0
TLS2_k127_4696243_10 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000005054 97.0
TLS2_k127_4696243_11 COGs COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferase of PMT family - - - 0.0000000000000000003986 104.0
TLS2_k127_4696243_12 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000001002 86.0
TLS2_k127_4696243_2 Extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 407.0
TLS2_k127_4696243_3 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 324.0
TLS2_k127_4696243_4 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006455 306.0
TLS2_k127_4696243_5 short-chain dehydrogenase reductase SDR K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 287.0
TLS2_k127_4696243_6 teichoic acid transport K01990,K09689,K09691,K09693 - 3.6.3.38,3.6.3.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000169 288.0
TLS2_k127_4696243_7 ABC-2 type transporter K09688,K09690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002438 256.0
TLS2_k127_4696243_8 Sigma-70 region 2 K03088 GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000001504 148.0
TLS2_k127_4696243_9 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950,K13940 - 2.7.6.3,4.1.2.25 0.000000000000000000000000000001834 131.0
TLS2_k127_4696606_0 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005017 440.0
TLS2_k127_4696606_1 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000033 285.0
TLS2_k127_4696606_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000006332 194.0
TLS2_k127_4696606_3 PFAM Enoyl-CoA hydratase isomerase - - - 0.000000000000000000000003263 104.0
TLS2_k127_4703257_0 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005306 552.0
TLS2_k127_4707160_0 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 474.0
TLS2_k127_4707160_1 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000003534 200.0
TLS2_k127_4707160_2 NADPH-dependent FMN reductase K00299 - 1.5.1.38 0.0000000000000000000002271 101.0
TLS2_k127_4708095_0 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 312.0
TLS2_k127_4708095_1 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009692 285.0
TLS2_k127_4710065_0 Large extracellular alpha-helical protein K06894 - - 0.0 1146.0
TLS2_k127_4728910_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 484.0
TLS2_k127_4728910_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000002147 198.0
TLS2_k127_4728910_2 PFAM isochorismatase hydrolase - - - 0.0000000000000000000000000000000000000000000004718 171.0
TLS2_k127_4729442_0 Voltage gated chloride channel K03281 - - 0.0000000000000000000000000000000000000005731 165.0
TLS2_k127_4729442_1 acetyltransferase - - - 0.0000000002103 72.0
TLS2_k127_4743499_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 371.0
TLS2_k127_4743499_1 THIoesterase K18700 - 3.1.2.29 0.00000000001027 66.0
TLS2_k127_4756884_0 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007025 432.0
TLS2_k127_4756884_1 HflC and HflK could encode or regulate a protease K04088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005544 380.0
TLS2_k127_4756884_2 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001049 265.0
TLS2_k127_476441_0 acyl-CoA transferases carnitine dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 336.0
TLS2_k127_476441_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000757 168.0
TLS2_k127_476441_2 Protein conserved in bacteria - - - 0.00000000000002403 75.0
TLS2_k127_4771879_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 4.165e-221 700.0
TLS2_k127_4771879_1 Domain of unknown function (DUF4328) - - - 0.00000000000000001575 98.0
TLS2_k127_4777203_0 Aconitase C-terminal domain K01681 - 4.2.1.3 1.081e-200 640.0
TLS2_k127_4777203_1 PrpF protein - - - 0.000000000000000000000000000000000000000000005656 166.0
TLS2_k127_4782761_0 transferase activity, transferring glycosyl groups K12996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 468.0
TLS2_k127_4782761_1 Sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 313.0
TLS2_k127_4782761_2 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000003845 127.0
TLS2_k127_4782761_3 Tetratricopeptide repeat - - - 0.0000000000000000000000007386 123.0
TLS2_k127_4783022_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 419.0
TLS2_k127_4783022_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070041,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 373.0
TLS2_k127_4783022_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 348.0
TLS2_k127_4783022_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001863 299.0
TLS2_k127_4783022_4 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919,K16924 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000000000000000000000000003361 199.0
TLS2_k127_4783022_5 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000002306 164.0
TLS2_k127_4783022_6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000008808 141.0
TLS2_k127_4783022_7 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000003374 79.0
TLS2_k127_4783022_8 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00007066 54.0
TLS2_k127_479534_0 Proton-conducting membrane transporter K00342,K05575 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 427.0
TLS2_k127_479534_1 FAD dependent oxidoreductase K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 417.0
TLS2_k127_479534_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343,K05573 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008219 425.0
TLS2_k127_479534_3 membrane - - - 0.00000000000000000000000000000000000000005082 155.0
TLS2_k127_4800244_0 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 377.0
TLS2_k127_4800244_1 PFAM Glycosyl transferase family 2 K20444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 303.0
TLS2_k127_4800244_2 - - - - 0.00000000000000000000000000000000000000000000000000000000001926 227.0
TLS2_k127_4800244_3 Methyltransferase domain - - - 0.0000000000000000001622 103.0
TLS2_k127_4810004_0 type VI secretion protein K11891 - - 2.218e-226 739.0
TLS2_k127_4810004_1 TIGRFAM type IV VI secretion system protein, DotU family K11892 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 442.0
TLS2_k127_4810004_2 type VI secretion protein K11893 - - 0.000000000000000000000000000000000000000000000000000000000000000001727 229.0
TLS2_k127_4813349_0 ABC transporter K15738 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 615.0
TLS2_k127_4813349_1 AhpC/TSA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 328.0
TLS2_k127_4813349_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004684 301.0
TLS2_k127_4813349_3 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K21323 - 1.14.13.229,1.14.19.48 0.00000000000000000000000000000000000000000000000000000000000000000000001341 247.0
TLS2_k127_4813349_4 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000004899 198.0
TLS2_k127_4813349_5 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000006166 65.0
TLS2_k127_4815832_0 Trypsin-like serine protease K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 302.0
TLS2_k127_4821828_0 cAMP biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000001213 228.0
TLS2_k127_4824096_0 4-phosphoerythronate dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008982 365.0
TLS2_k127_4824096_1 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000000006549 216.0
TLS2_k127_4824096_2 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000002171 116.0
TLS2_k127_4824096_3 Protein of unknown function, DUF488 - - - 0.000000000000000005315 93.0
TLS2_k127_4825087_0 Xaa-Pro aminopeptidase K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 449.0
TLS2_k127_4825087_1 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.000000000000000000000000000000000000000000000000000000001339 211.0
TLS2_k127_4833640_0 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000345 243.0
TLS2_k127_4833640_1 HpcH/HpaI aldolase/citrate lyase family - - - 0.0000000000000000000000000000000000000000000002518 170.0
TLS2_k127_4833640_2 ABC transporter substrate-binding protein K02035 - - 0.00008185 48.0
TLS2_k127_4836799_0 Belongs to the ClpA ClpB family K03695,K03696 - - 3.389e-316 988.0
TLS2_k127_4836799_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 570.0
TLS2_k127_4836799_2 Surface antigen K07277 GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007976 514.0
TLS2_k127_4836799_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 406.0
TLS2_k127_4836799_4 ABC-type transport system involved in lipoprotein release permease component K02004,K09808 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006514 357.0
TLS2_k127_4836799_5 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 335.0
TLS2_k127_4836799_6 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005413 243.0
TLS2_k127_4836799_7 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000001198 216.0
TLS2_k127_4836799_8 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000001611 136.0
TLS2_k127_4836799_9 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000007915 85.0
TLS2_k127_4837078_0 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002377 271.0
TLS2_k127_4837078_1 Amino-transferase class IV - - - 0.00000000000000000000000000000000000000000000000000000000000000007823 233.0
TLS2_k127_4837956_0 Adenylate and Guanylate cyclase catalytic domain - - - 2.902e-262 839.0
TLS2_k127_4837956_1 Protein kinase domain K12132 - 2.7.11.1 0.0001969 55.0
TLS2_k127_4845684_0 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003217 486.0
TLS2_k127_4845684_1 Beta-eliminating lyase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 418.0
TLS2_k127_4845684_10 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000001331 165.0
TLS2_k127_4845684_11 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.0000000000000000000000000000000000001325 141.0
TLS2_k127_4845684_12 PFAM ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000001932 141.0
TLS2_k127_4845684_13 Belongs to the bacterial ribosomal protein bL36 family K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000002859 67.0
TLS2_k127_4845684_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 326.0
TLS2_k127_4845684_3 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 299.0
TLS2_k127_4845684_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001305 273.0
TLS2_k127_4845684_5 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004187 271.0
TLS2_k127_4845684_6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000001661 250.0
TLS2_k127_4845684_7 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000002158 194.0
TLS2_k127_4845684_9 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000001551 177.0
TLS2_k127_4849818_0 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002836 539.0
TLS2_k127_4849818_1 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001375 252.0
TLS2_k127_4849818_2 3-dehydroquinate synthase activity K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000001097 180.0
TLS2_k127_4849818_3 Biotin-requiring enzyme K02160 - - 0.00000000000000000000000000002747 123.0
TLS2_k127_4849818_4 Tetratricopeptide repeat - - - 0.00001964 57.0
TLS2_k127_4855278_0 PFAM Pyridine nucleotide-disulphide oxidoreductase, FAD NAD(P)-binding domain, pyridine nucleotide-disulfide oxidoreductase dimerization region, FAD-dependent pyridine nucleotide-disulfide oxidoreductase K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 446.0
TLS2_k127_4855278_1 Component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006149 316.0
TLS2_k127_4855831_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.77e-208 661.0
TLS2_k127_4855831_1 TIGRFAM YihY family protein (not ribonuclease BN) K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000001136 262.0
TLS2_k127_4855831_2 Cupin domain - - - 0.000000000000000000000000000000000000000002857 173.0
TLS2_k127_4857212_0 overlaps another CDS with the same product name - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004065 374.0
TLS2_k127_4857212_1 - - - - 0.000000000000000007915 85.0
TLS2_k127_4860514_0 Domain of unknown function (DUF4397) - - - 0.00000000000001378 85.0
TLS2_k127_4860514_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.0002776 53.0
TLS2_k127_4866899_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 3.128e-266 842.0
TLS2_k127_4866899_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 2.583e-246 792.0
TLS2_k127_4866899_2 leucyl-tRNA aminoacylation K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 7.811e-235 744.0
TLS2_k127_4866899_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 567.0
TLS2_k127_4866899_4 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 384.0
TLS2_k127_4866899_5 'glutamate synthase K00528,K03388 - 1.18.1.2,1.19.1.1,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005438 368.0
TLS2_k127_4866899_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 327.0
TLS2_k127_4866899_7 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000001264 188.0
TLS2_k127_4866899_8 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000002592 191.0
TLS2_k127_4866899_9 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000002705 109.0
TLS2_k127_4873704_0 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 4.207e-204 640.0
TLS2_k127_4873704_1 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005239 322.0
TLS2_k127_4873704_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002765 275.0
TLS2_k127_4881800_0 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004877 279.0
TLS2_k127_4881800_1 Tryptophan halogenase - - - 0.0000000000000000000000000000000000000000001672 166.0
TLS2_k127_4881800_2 Luciferase-like monooxygenase K20938 - 1.14.14.28 0.00000000000000000000000000000418 121.0
TLS2_k127_4883105_0 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000003703 233.0
TLS2_k127_4883105_1 Endoribonuclease L-PSP - - - 0.0000000000000000002983 93.0
TLS2_k127_4883105_2 EcsC protein family - - - 0.00006235 51.0
TLS2_k127_488356_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 3.294e-203 642.0
TLS2_k127_488356_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 514.0
TLS2_k127_488356_2 PFAM AIR synthase related protein domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001539 255.0
TLS2_k127_488356_3 Archease protein family (MTH1598/TM1083) - - - 0.00000000000000000000000000004849 121.0
TLS2_k127_488356_4 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.000000000000000000000002723 114.0
TLS2_k127_488356_5 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000007753 93.0
TLS2_k127_488356_6 Cbs domain - - - 0.000000000002132 74.0
TLS2_k127_4884296_0 Protein of unknown function (DUF3604) - - - 0.0 1026.0
TLS2_k127_4884296_1 HupE / UreJ protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001066 278.0
TLS2_k127_4884296_2 HupE / UreJ protein K03192 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000003408 221.0
TLS2_k127_4884296_3 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000773 218.0
TLS2_k127_4884296_4 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000000101 160.0
TLS2_k127_4884296_5 HupE / UreJ protein - - - 0.00000000000000000000000002207 120.0
TLS2_k127_4884296_6 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000007062 65.0
TLS2_k127_4887605_0 Acetyl xylan esterase (AXE1) - - - 0.0000000000000000000000000000000000000000004971 166.0
TLS2_k127_4887605_1 - - - - 0.0000000000000000000176 93.0
TLS2_k127_4887605_2 - - - - 0.000000000000005975 79.0
TLS2_k127_4889298_0 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000008433 196.0
TLS2_k127_4893570_0 III protein, CoA-transferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 524.0
TLS2_k127_4893570_1 aldo-keto reductase (NADP) activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004823 362.0
TLS2_k127_4893570_2 Amidohydrolase K03392,K22213 - 4.1.1.45,4.1.1.52 0.00000000000000000000000000000000000000000000000000000000009068 218.0
TLS2_k127_4893570_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.0000000000000000000000000001572 123.0
TLS2_k127_4893570_4 Cobalamin-independent synthase, Catalytic domain - - - 0.000000000000000000000000005345 111.0
TLS2_k127_4900292_0 LUD domain K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 492.0
TLS2_k127_4900292_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 376.0
TLS2_k127_4900292_2 4Fe-4S binding domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 295.0
TLS2_k127_4900292_3 Fe-S oxidoreductase K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000002483 242.0
TLS2_k127_4900292_4 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000745 230.0
TLS2_k127_4900292_5 LUD domain K00782,K18929 - - 0.0000000000000000000000003489 121.0
TLS2_k127_4900292_6 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000003431 104.0
TLS2_k127_4900292_7 Uncharacterized conserved protein (DUF2203) - - - 0.0000000000000000001002 94.0
TLS2_k127_4900292_8 HAD-hyrolase-like K01560,K07025,K08723 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008655,GO:0009058,GO:0009112,GO:0009410,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019856,GO:0019859,GO:0030145,GO:0034641,GO:0034654,GO:0042221,GO:0042578,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.3.5,3.8.1.2 0.00000000000071 80.0
TLS2_k127_4901084_0 Aldo/keto reductase family K00064 - 1.1.1.122 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008254 308.0
TLS2_k127_4901084_1 Amidohydrolase family - - - 0.00000000000000000000003071 108.0
TLS2_k127_4902199_0 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000045 279.0
TLS2_k127_4902199_1 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000005035 195.0
TLS2_k127_4902199_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000001473 124.0
TLS2_k127_4907881_0 PFAM ABC transporter related K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 347.0
TLS2_k127_4907881_1 PFAM Extracellular solute-binding protein, family 3 K02030 - - 0.000000000000000000000000000000000000000000000008076 183.0
TLS2_k127_4912525_0 Glutamate synthase central domain K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1471.0
TLS2_k127_4912525_1 TIGRFAM glutamate synthase, NADH NADPH, small subunit K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 8.422e-202 638.0
TLS2_k127_4912525_10 - - - - 0.0000000003165 62.0
TLS2_k127_4912525_2 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002313 476.0
TLS2_k127_4912525_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 462.0
TLS2_k127_4912525_4 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008567 435.0
TLS2_k127_4912525_5 peroxidase activity K00435 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003218 274.0
TLS2_k127_4912525_6 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000349 273.0
TLS2_k127_4912525_7 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000002032 159.0
TLS2_k127_4912525_8 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000001286 156.0
TLS2_k127_4912525_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.000000000000000000000000004256 118.0
TLS2_k127_4914638_0 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000007535 233.0
TLS2_k127_4914638_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000003868 70.0
TLS2_k127_4914638_2 Sulfotransferase domain - - - 0.0001209 45.0
TLS2_k127_4919738_0 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006862 340.0
TLS2_k127_4919738_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000001381 218.0
TLS2_k127_4919947_0 D-amino-acid K18482 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008153,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0019438,GO:0019752,GO:0032787,GO:0042537,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046482,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003865 304.0
TLS2_k127_4919947_1 Peptidase dimerisation domain K01439,K05831 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000005025 275.0
TLS2_k127_4919947_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000004234 218.0
TLS2_k127_4921363_0 Dehydrogenase E1 component K21416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 343.0
TLS2_k127_4921363_1 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.0000000000000000000000000000000000000000000000921 173.0
TLS2_k127_4921363_2 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs K03520 - 1.2.5.3 0.000000000000000000000000000000006647 134.0
TLS2_k127_4922444_0 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005833 485.0
TLS2_k127_4922444_1 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000001408 190.0
TLS2_k127_4924544_0 C-terminal, D2-small domain, of ClpB protein K11907 - - 0.0 1204.0
TLS2_k127_4924544_1 Rhs element Vgr protein K11904 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 617.0
TLS2_k127_4924544_11 - - - - 0.0000000000006983 81.0
TLS2_k127_4924544_2 Uncharacterized protein conserved in bacteria (DUF2169) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008851 316.0
TLS2_k127_4924544_3 deoxyhypusine monooxygenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 304.0
TLS2_k127_4924544_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001401 252.0
TLS2_k127_4924544_5 synthase K00647 - 2.3.1.41 0.000000000000000000000000000000000000000000000000000000000000000001151 240.0
TLS2_k127_4924544_6 PAAR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000003092 221.0
TLS2_k127_4924544_7 Domain of unknown function (DUF4150) - - - 0.000000000000000000000000000000000000000000000000000000000001477 216.0
TLS2_k127_4924544_8 - - - - 0.000000000000000000000000000000001474 143.0
TLS2_k127_4924544_9 TIGRFAM type VI secretion system FHA domain protein K07169,K11913 - - 0.0000000000000000000009598 102.0
TLS2_k127_4925534_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 4.623e-259 820.0
TLS2_k127_4925534_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 613.0
TLS2_k127_4925534_2 PFAM SAICAR synthetase K01756,K01923 - 4.3.2.2,6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009491 304.0
TLS2_k127_4925534_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 303.0
TLS2_k127_4925534_4 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000002057 134.0
TLS2_k127_4925534_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000009006 90.0
TLS2_k127_4926088_0 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000084 229.0
TLS2_k127_4933537_0 Family of unknown function (DUF1028) - - - 0.0000000000000000000000000000000000000000000000059 182.0
TLS2_k127_4933537_1 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 0.0000000000000000000000001182 110.0
TLS2_k127_493645_0 NAD binding K00333,K05579,K13378 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 444.0
TLS2_k127_493645_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000001656 216.0
TLS2_k127_493645_2 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K00332 - 1.6.5.3 0.00000000000000000000000002486 113.0
TLS2_k127_493645_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000001875 64.0
TLS2_k127_493645_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330,K05574 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.0000005263 51.0
TLS2_k127_4940808_0 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 386.0
TLS2_k127_4940808_1 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000001509 238.0
TLS2_k127_4940808_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000002094 186.0
TLS2_k127_4940808_3 PFAM luciferase-like K00320 - 1.5.98.2 0.0000000000000000000000000002562 121.0
TLS2_k127_4945394_0 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 391.0
TLS2_k127_4945394_1 PFAM Rieske 2Fe-2S domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 347.0
TLS2_k127_4945394_2 Belongs to the MIP aquaporin (TC 1.A.8) family K02440,K06188 - - 0.000000000000000000000000000000000000003759 151.0
TLS2_k127_4945394_3 Thioesterase superfamily - - - 0.000001471 59.0
TLS2_k127_4947414_0 KR domain K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 347.0
TLS2_k127_4947414_1 Acyl-CoA dehydrogenase, N-terminal domain K04117 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005336 344.0
TLS2_k127_4947414_2 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000009423 184.0
TLS2_k127_4954475_0 TOBE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005913 481.0
TLS2_k127_4954475_1 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000164 220.0
TLS2_k127_4954475_2 F420-dependent oxidoreductase, MSMEG_3544 family - - - 0.000000001728 70.0
TLS2_k127_4956567_0 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008887 385.0
TLS2_k127_4956567_1 Poly A polymerase head domain K00970,K00974,K07276,K19545 - 2.7.7.19,2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000009042 282.0
TLS2_k127_4956567_2 Pfam:KaiC - - - 0.0000000000000000000000000005717 119.0
TLS2_k127_4956567_3 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.0000000002666 69.0
TLS2_k127_4956567_4 - - - - 0.0003345 45.0
TLS2_k127_4957145_0 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 614.0
TLS2_k127_4957145_1 PFAM SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007485 280.0
TLS2_k127_4957145_2 Protein of unknown function, DUF255 K06888 - - 0.00000000000000000000000000000000006221 139.0
TLS2_k127_4957145_3 sulfur oxidation protein (SoxY) K17226 - - 0.000000009729 57.0
TLS2_k127_4957145_4 Sulphur oxidation protein SoxZ K17227 - - 0.0000002606 56.0
TLS2_k127_4959825_0 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000000000009414 164.0
TLS2_k127_4959825_1 metal-dependent hydrolase with the TIM-barrel fold - - - 0.00000000003237 64.0
TLS2_k127_4959825_2 Nitroreductase - - - 0.000000007808 61.0
TLS2_k127_4959825_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000008755 60.0
TLS2_k127_4959825_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000003936 61.0
TLS2_k127_4959825_5 radical SAM domain protein - - - 0.00001984 53.0
TLS2_k127_4961763_0 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000001723 249.0
TLS2_k127_4961763_1 Fimbrial assembly protein (PilN) K02663 - - 0.00005901 55.0
TLS2_k127_4981119_0 May be involved in recombinational repair of damaged DNA K03631 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 400.0
TLS2_k127_4981119_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 318.0
TLS2_k127_4981119_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0000000000000000000000000000000000000000000000000002904 187.0
TLS2_k127_4981119_3 ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000004406 132.0
TLS2_k127_5003447_0 dipeptide transport K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 602.0
TLS2_k127_5003447_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000095 549.0
TLS2_k127_5003447_10 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000009732 207.0
TLS2_k127_5003447_11 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000000000000000000000000009149 133.0
TLS2_k127_5003447_12 Cupin 2, conserved barrel K21700 - - 0.00000000000000000000000049 119.0
TLS2_k127_5003447_13 5-oxoprolinase K01473 - 3.5.2.14 0.0000003463 54.0
TLS2_k127_5003447_2 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 411.0
TLS2_k127_5003447_3 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 336.0
TLS2_k127_5003447_4 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000097 286.0
TLS2_k127_5003447_5 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001944 272.0
TLS2_k127_5003447_6 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006524 275.0
TLS2_k127_5003447_7 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008001 270.0
TLS2_k127_5003447_8 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000004359 239.0
TLS2_k127_5003447_9 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000001725 204.0
TLS2_k127_5006909_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004296 510.0
TLS2_k127_5006909_1 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003935 404.0
TLS2_k127_5006909_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 374.0
TLS2_k127_5006909_3 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 336.0
TLS2_k127_5006909_4 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000001513 228.0
TLS2_k127_5006909_5 Tripartite ATP-independent Periplasmic Transporter - - - 0.000000000000000000000000000000000000000000005377 172.0
TLS2_k127_5006909_6 Hint module K06224 - - 0.0000000000000000000000003165 120.0
TLS2_k127_5006909_7 Adenylate cyclase - - - 0.0000931 46.0
TLS2_k127_5007198_0 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 527.0
TLS2_k127_5007198_1 PFAM glutaredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 361.0
TLS2_k127_5007198_2 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000000000000000000000000000000000002591 149.0
TLS2_k127_5007198_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000008179 99.0
TLS2_k127_5020176_0 DNA polymerase type-B family K02336 - 2.7.7.7 1.403e-214 688.0
TLS2_k127_5020176_1 Radical SAM - - - 0.000000000000000000000004445 106.0
TLS2_k127_5021996_0 3-isopropylmalate dehydrogenase activity K00052,K05824 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0047046,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85,1.1.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000005629 252.0
TLS2_k127_5021996_1 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000001692 219.0
TLS2_k127_5021996_2 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000001231 136.0
TLS2_k127_5022909_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000001792 192.0
TLS2_k127_5022909_1 PFAM Peptidase family M48 - - - 0.0000000000000009598 84.0
TLS2_k127_5036877_0 PFAM type I phosphodiesterase nucleotide pyrophosphatase K19670 - 3.11.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 518.0
TLS2_k127_5036877_1 TIGRFAM Urea carboxylase-associated protein 1 K09967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003872 251.0
TLS2_k127_5036877_2 Ketopantoate reductase PanE/ApbA C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000001983 244.0
TLS2_k127_5036877_3 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K07052 - 1.16.3.1 0.00000000000000000000000000000000000000000003513 179.0
TLS2_k127_5036877_4 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000003147 139.0
TLS2_k127_5036877_5 Redoxin K03564 - 1.11.1.15 0.000000000006638 69.0
TLS2_k127_5036877_6 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 0.0000000000103 69.0
TLS2_k127_5042452_0 Aconitase family (aconitate hydratase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005863 599.0
TLS2_k127_5042452_1 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K01003,K01841 - 4.1.1.3,5.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 420.0
TLS2_k127_5042452_2 Cupin domain - - - 0.000000000000001096 81.0
TLS2_k127_5064110_0 acetyl-coa acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004639 372.0
TLS2_k127_5064110_1 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.00000000000000000000000000000000000000000000000000000000008321 220.0
TLS2_k127_5064110_2 Amidohydrolase - - - 0.00000000000000000000000000000000006065 144.0
TLS2_k127_5085636_0 Major Facilitator Superfamily - - - 0.000000000000000000000000009647 123.0
TLS2_k127_5085636_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000003774 89.0
TLS2_k127_5086257_0 COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - 5.551e-263 821.0
TLS2_k127_5086257_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004998 314.0
TLS2_k127_5086257_2 3'-5' exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000001839 267.0
TLS2_k127_5086257_3 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000001839 190.0
TLS2_k127_5086257_4 - - - - 0.000000000000000000002903 105.0
TLS2_k127_5086257_5 His Kinase A (phosphoacceptor) domain K02482 - 2.7.13.3 0.0000000000004785 76.0
TLS2_k127_5086257_6 Methyl-accepting chemotaxis protein K03406 - - 0.0000000000005268 82.0
TLS2_k127_5090425_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000002911 221.0
TLS2_k127_5090425_1 PFAM TRAP dicarboxylate transporter- DctP subunit - - - 0.00000000000000000000000008904 115.0
TLS2_k127_5090425_2 PFAM Tripartite ATP-independent periplasmic transporter DctQ component - - - 0.000000000000007891 81.0
TLS2_k127_5090506_0 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000000001168 205.0
TLS2_k127_5090506_1 ATP hydrolysis coupled proton transport - - - 0.000000000000000000000000000009401 139.0
TLS2_k127_5090506_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0008150,GO:0040007 - 0.000002321 50.0
TLS2_k127_5090506_3 Metal binding domain of Ada K00567,K10778 GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 2.1.1.63 0.00002208 49.0
TLS2_k127_5108842_0 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004356 451.0
TLS2_k127_5108842_1 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007554 381.0
TLS2_k127_5108842_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 315.0
TLS2_k127_5112965_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 551.0
TLS2_k127_5112965_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 370.0
TLS2_k127_5112965_10 Ribosomal L32p protein family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.00000000000000002492 87.0
TLS2_k127_5112965_2 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 370.0
TLS2_k127_5112965_3 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003245 354.0
TLS2_k127_5112965_4 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 306.0
TLS2_k127_5112965_5 reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000117 259.0
TLS2_k127_5112965_6 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000005563 246.0
TLS2_k127_5112965_7 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000000000005849 192.0
TLS2_k127_5112965_8 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000002838 111.0
TLS2_k127_5112965_9 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000003291 115.0
TLS2_k127_5116800_0 Pyruvate ferredoxin/flavodoxin oxidoreductase K04090 - 1.2.7.8 0.0 1270.0
TLS2_k127_5116800_1 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 361.0
TLS2_k127_5116800_2 lipoprotein transporter activity K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 293.0
TLS2_k127_5116800_3 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.00000000000000000000000000000000000000000000000000000000008163 212.0
TLS2_k127_5116800_4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.0000000000000000000000005188 111.0
TLS2_k127_5119847_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 3.747e-246 769.0
TLS2_k127_5119847_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 291.0
TLS2_k127_5119847_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000006952 139.0
TLS2_k127_5119847_3 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.00000000000000002674 89.0
TLS2_k127_5126378_0 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005098 265.0
TLS2_k127_5126378_1 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001506 249.0
TLS2_k127_5126378_2 ABC-type branched-chain amino acid transport K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000001339 254.0
TLS2_k127_5126378_3 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000003289 241.0
TLS2_k127_5126378_4 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000004337 215.0
TLS2_k127_5126378_5 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000003045 192.0
TLS2_k127_5126378_6 Luciferase-like monooxygenase - - - 0.00000000000000005932 85.0
TLS2_k127_5135846_0 COG0457 FOG TPR repeat - - - 9.186e-213 687.0
TLS2_k127_5135846_1 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 290.0
TLS2_k127_5165439_0 AMP-binding enzyme K00666,K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 535.0
TLS2_k127_5165439_1 protein conserved in bacteria K09930 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 363.0
TLS2_k127_5165439_2 Putative DNA-binding domain - - - 0.0000000000000000000000000000003187 135.0
TLS2_k127_5165439_3 - - - - 0.000000007425 61.0
TLS2_k127_5165439_4 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - 0.0005457 50.0
TLS2_k127_5166511_0 AMP-binding enzyme K01897 - 6.2.1.3 3.358e-197 626.0
TLS2_k127_5166511_1 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000803 400.0
TLS2_k127_5185720_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 357.0
TLS2_k127_5185720_1 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 360.0
TLS2_k127_5185720_2 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001658 291.0
TLS2_k127_5185720_3 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005833 263.0
TLS2_k127_5215280_0 Type II secretion system (T2SS), protein G K02456 - - 0.00000000007315 63.0
TLS2_k127_5215280_1 TIGRFAM general secretion pathway protein H K02457 - - 0.000000000208 68.0
TLS2_k127_5215280_2 type IV pilus modification protein PilV K02458 - - 0.0000004853 60.0
TLS2_k127_5215280_3 pilus assembly protein PilW K02459 - - 0.0003549 51.0
TLS2_k127_5222438_0 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000006411 113.0
TLS2_k127_526852_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 404.0
TLS2_k127_526852_1 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000006603 124.0
TLS2_k127_526852_2 Metal binding domain of Ada K00567 - 2.1.1.63 0.0000001864 63.0
TLS2_k127_5281918_0 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000004561 198.0
TLS2_k127_5281918_1 Carbon-nitrogen hydrolase - - - 0.000000000000008867 78.0
TLS2_k127_5283892_0 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 350.0
TLS2_k127_5283892_1 Ferredoxin - - - 0.0000000000000000000000000000000000000001173 155.0
TLS2_k127_5306183_0 hydrogenase large subunit K06281 - 1.12.99.6 2.506e-264 827.0
TLS2_k127_5306183_1 ABC-type dipeptide transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 346.0
TLS2_k127_5306183_2 Anion-transporting ATPase - - - 0.0000000000000000000000000000000000001137 145.0
TLS2_k127_5306183_3 COG0694 Thioredoxin-like proteins and domains - - - 0.00000000000000000000000001667 121.0
TLS2_k127_5306183_4 TIGRFAM hydrogenase maturation protease K03605 - - 0.0000000000000000000000001256 122.0
TLS2_k127_5306183_5 - - - - 0.00000000000000000000001325 107.0
TLS2_k127_5306183_6 HxlR-like helix-turn-helix - - - 0.000000000005472 78.0
TLS2_k127_5308275_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 3.6.3.14 2.136e-247 771.0
TLS2_k127_5308275_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000163 133.0
TLS2_k127_5308275_2 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000002709 113.0
TLS2_k127_5308275_3 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000000007402 81.0
TLS2_k127_53303_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 380.0
TLS2_k127_53303_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000002119 212.0
TLS2_k127_53303_2 DNA polymerase K02337 GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.00000000000000000000000000000000000000000000000006245 192.0
TLS2_k127_5332300_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007639 330.0
TLS2_k127_5332300_1 PFAM OsmC family protein - - - 0.0000000000000000000000000000000000768 134.0
TLS2_k127_5332300_2 Adenylate cyclase - - - 0.000000000001284 71.0
TLS2_k127_5354414_0 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004689 486.0
TLS2_k127_5354414_1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 311.0
TLS2_k127_5354414_2 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000004952 208.0
TLS2_k127_5354414_3 protein conserved in cyanobacteria - - - 0.00000000000000000000000000000000000000000005118 167.0
TLS2_k127_5354414_4 Protein of unknown function (DUF3237) - - - 0.000000000000000000000000000000000000000008075 162.0
TLS2_k127_5354414_5 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.0000000000000000006716 94.0
TLS2_k127_5354414_6 WD40-like Beta Propeller Repeat - - - 0.00000000000008783 79.0
TLS2_k127_5354414_7 AAA domain - - - 0.0002795 52.0
TLS2_k127_5368969_0 Glycosyl hydrolases family 15 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007196 368.0
TLS2_k127_5368969_1 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008654 250.0
TLS2_k127_5368969_2 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000006057 106.0
TLS2_k127_5368969_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000003679 96.0
TLS2_k127_5368969_5 - - - - 0.00000002358 58.0
TLS2_k127_5409218_0 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008737 334.0
TLS2_k127_5409218_1 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 316.0
TLS2_k127_5409218_2 - - - - 0.0000000000000000000000000000000000476 140.0
TLS2_k127_5428160_0 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003067 264.0
TLS2_k127_5428160_1 thioesterase involved in non-ribosomal peptide biosynthesis K01071 - 3.1.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000007006 250.0
TLS2_k127_5428160_2 4'-phosphopantetheinyl transferase superfamily K06133 - - 0.00000000000000000000000000000000000000000003088 179.0
TLS2_k127_544149_0 EH COG0115 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002257 284.0
TLS2_k127_544149_1 Amidohydrolase family K01465,K06015 - 3.5.1.81,3.5.2.3 0.00000000000000000000000000000001144 129.0
TLS2_k127_544149_2 peroxiredoxin activity K01607 - 4.1.1.44 0.0000000000003999 70.0
TLS2_k127_549920_0 Glycosyl hydrolases family 15 - - - 1.607e-227 709.0
TLS2_k127_549920_1 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005448 307.0
TLS2_k127_549920_2 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005706 281.0
TLS2_k127_549920_3 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000165 258.0
TLS2_k127_549920_4 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000001258 254.0
TLS2_k127_549920_5 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000167 239.0
TLS2_k127_549920_6 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000006297 196.0
TLS2_k127_549920_7 Aminoglycoside phosphotransferase - - - 0.0008219 51.0
TLS2_k127_5499749_0 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02052 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 337.0
TLS2_k127_5499749_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02055 - - 0.000000000000000000000000000000000000000000000000000000001068 212.0
TLS2_k127_5499749_2 Psort location Cytoplasmic, score 8.87 K14591 - - 0.0000000000000000000000000000000007338 151.0
TLS2_k127_5548933_0 alpha beta alpha domain I K01840,K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 430.0
TLS2_k127_5548933_1 Inositol monophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000007454 231.0
TLS2_k127_5548933_2 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000009383 178.0
TLS2_k127_5548933_3 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.000000000000000000000000000000001051 134.0
TLS2_k127_5548933_4 Protein of unknown function (DUF1015) - - - 0.0000000000000000001863 92.0
TLS2_k127_56068_0 glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000001268 160.0
TLS2_k127_56068_1 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000324 128.0
TLS2_k127_5612930_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006661 468.0
TLS2_k127_5612930_1 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 411.0
TLS2_k127_5612930_2 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 286.0
TLS2_k127_5612930_3 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000001789 215.0
TLS2_k127_5612930_4 Luciferase-like monooxygenase K20938 - 1.14.14.28 0.0000007245 51.0
TLS2_k127_5614168_0 CoA-transferase family III K07544,K07749 - 2.8.3.15,2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 401.0
TLS2_k127_5614168_1 Belongs to the ABC transporter superfamily K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006843 329.0
TLS2_k127_5614168_2 methylisocitrate lyase activity K20454 - 4.1.3.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001108 279.0
TLS2_k127_5614168_3 Binding-protein-dependent transport system inner membrane component K02054 - - 0.00000000000000000000000000000000000000000000000000000001061 210.0
TLS2_k127_5614168_4 Spermidine putrescine ABC transporter ATP-binding protein K02053 - - 0.000000000000000000000000000000000000002756 158.0
TLS2_k127_5614168_5 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.0000000000000000000000000000000000004406 154.0
TLS2_k127_5614168_6 ATPase involved in DNA repair K03546 - - 0.000000000000000000000000000000000001269 160.0
TLS2_k127_5614168_7 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.00000000000000000000000000000000001378 148.0
TLS2_k127_5614168_8 Bacterial extracellular solute-binding protein K02055 - - 0.000000000000000000001131 108.0
TLS2_k127_5614398_0 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001898 250.0
TLS2_k127_5614398_1 PFAM luciferase-like - - - 0.0000000000000000000000000000000000000000000000000000000000000001748 234.0
TLS2_k127_5614398_2 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.00002472 57.0
TLS2_k127_5614840_0 Alanine-glyoxylate amino-transferase - - - 0.000000000000000000000000000000000000000000000008111 183.0
TLS2_k127_5614840_1 HAD-hyrolase-like - - - 0.000000000000000000005159 96.0
TLS2_k127_5614840_2 - - - - 0.0001579 50.0
TLS2_k127_5614861_0 Isocitrate/isopropylmalate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007285 540.0
TLS2_k127_5614861_1 mandelate racemase muconate lactonizing - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 524.0
TLS2_k127_5614861_2 PFAM Type II secretion system protein E K02454,K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 399.0
TLS2_k127_5614861_3 Peptidyl-prolyl cis-trans isomerase K01802,K03772,K03773 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000001311 279.0
TLS2_k127_5614861_4 Bacterial protein of unknown function (DUF853) K06915 - - 0.00000000000000000000000000000000000000000001322 166.0
TLS2_k127_5614861_5 symporter - - - 0.00000000000000000000000001158 125.0
TLS2_k127_5614861_6 PFAM response regulator receiver - - - 0.00000000000000000000003683 103.0
TLS2_k127_5616308_0 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01537 - 3.6.3.8 0.0 1313.0
TLS2_k127_5616308_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 7.29e-287 897.0
TLS2_k127_5616308_2 Belongs to the CinA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 627.0
TLS2_k127_5616308_3 histidine kinase, HAMP K13598 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 566.0
TLS2_k127_5616308_4 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02481,K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005193 528.0
TLS2_k127_5616308_5 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 456.0
TLS2_k127_5616308_6 F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003796 259.0
TLS2_k127_5616308_7 metal-dependent hydrolase with the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000001641 248.0
TLS2_k127_5616308_8 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535,K16363 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108,4.2.1.59 0.0000000000000000000000000000000000000000000000006209 181.0
TLS2_k127_5616308_9 - - - - 0.000001126 57.0
TLS2_k127_5617081_0 PFAM Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006909 592.0
TLS2_k127_5617081_1 Phospholipase D. Active site motifs. - - - 0.00000000000000000007599 94.0
TLS2_k127_5617081_2 - - - - 0.0000000000000009428 78.0
TLS2_k127_5629262_0 SMART Elongator protein 3 MiaB NifB - - - 8.827e-226 704.0
TLS2_k127_5629262_1 COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 346.0
TLS2_k127_5629262_2 PFAM extracellular solute-binding protein family 3 K02030,K09969,K10001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005436 267.0
TLS2_k127_5629262_3 [2Fe-2S] binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002875 260.0
TLS2_k127_5632663_0 DEAD DEAH box K03724 - - 0.0 1349.0
TLS2_k127_5633574_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 2.641e-252 787.0
TLS2_k127_5633574_1 Helix-hairpin-helix domain K04477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 323.0
TLS2_k127_5633574_2 transporter K11106 - - 0.000000000000000000000000000004853 121.0
TLS2_k127_5634290_0 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 345.0
TLS2_k127_5634290_1 Isochorismatase family - - - 0.00000000000000000000000000002995 122.0
TLS2_k127_5637829_0 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 388.0
TLS2_k127_5637829_1 N-methylhydantoinase B acetone carboxylase alpha subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 336.0
TLS2_k127_5640990_0 succinate dehydrogenase, flavoprotein subunit K00239 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4 1.791e-280 870.0
TLS2_k127_5640990_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 474.0
TLS2_k127_5640990_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007185 424.0
TLS2_k127_5640990_3 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 383.0
TLS2_k127_5640990_4 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000005289 192.0
TLS2_k127_5640990_5 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000004256 66.0
TLS2_k127_5640990_6 Bacterial PH domain - - - 0.00008453 55.0
TLS2_k127_5641276_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 1.801e-217 691.0
TLS2_k127_5641276_1 FAD dependent oxidoreductase K13796 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 604.0
TLS2_k127_5641276_2 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 512.0
TLS2_k127_5641276_3 formamidase K01455 - 3.5.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009872 407.0
TLS2_k127_5641276_4 COG1062 Zn-dependent alcohol dehydrogenases, class III K00001,K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 392.0
TLS2_k127_5641276_5 Amidohydrolase family K01464 - 3.5.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 385.0
TLS2_k127_5641276_6 CoA-transferase family III K18702 - 2.8.3.19 0.000000000000000000000000000000000000000000000000000000000000000000000002351 259.0
TLS2_k127_5641276_7 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000000000000006029 213.0
TLS2_k127_5643419_0 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 382.0
TLS2_k127_5643419_1 Conserved protein of dim6 ntab family - - - 0.0000000000000000000000000000000000000000000000000000000001043 210.0
TLS2_k127_5643419_2 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000001432 195.0
TLS2_k127_5645448_0 Asparagine synthase K01953 - 6.3.5.4 6.489e-237 741.0
TLS2_k127_5645448_1 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 535.0
TLS2_k127_5645448_2 Involved in molybdopterin and thiamine biosynthesis, family 2 - - - 0.00009759 56.0
TLS2_k127_5646449_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 371.0
TLS2_k127_5646449_1 gluconolactonase K01053,K14274 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008376 297.0
TLS2_k127_5646449_2 extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000001186 175.0
TLS2_k127_5651873_0 TIGRFAM Cell division ATP-binding protein FtsE K09812 - - 0.000000000000000000000000000000000000000000000000000000000008673 218.0
TLS2_k127_5651873_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000003529 109.0
TLS2_k127_5651873_2 Part of the ABC transporter FtsEX involved in cellular division K09811 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032153,GO:0044425,GO:0044464,GO:0051301,GO:0071944 - 0.000000223 61.0
TLS2_k127_5653253_0 PFAM Carbamoyl-phosphate synthase L chain ATP-binding K01955 - 6.3.5.5 0.0 1405.0
TLS2_k127_5653253_1 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008071 510.0
TLS2_k127_5653253_10 - - - - 0.00000000006495 70.0
TLS2_k127_5653253_11 Protein of unknown function (DUF2877) - - - 0.0000000002601 70.0
TLS2_k127_5653253_12 - - - - 0.0000002626 64.0
TLS2_k127_5653253_13 - - - - 0.000003359 57.0
TLS2_k127_5653253_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003657 495.0
TLS2_k127_5653253_3 Protein of unknown function (DUF1116) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 454.0
TLS2_k127_5653253_4 Belongs to the ATCase OTCase family K00608,K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009844 402.0
TLS2_k127_5653253_5 CoA-ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008385 378.0
TLS2_k127_5653253_6 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000008533 241.0
TLS2_k127_5653253_7 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000007128 251.0
TLS2_k127_5653253_8 Uridine 5-monophosphate K13421 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0016036,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046686,GO:0050896,GO:0051716,GO:0071496 2.4.2.10,4.1.1.23 0.000000000000000000000000000000000000000000000000002263 192.0
TLS2_k127_5653253_9 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000001669 192.0
TLS2_k127_5654274_0 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 428.0
TLS2_k127_5654274_1 COG0457 FOG TPR repeat - - - 0.00000000000000000000000001355 117.0
TLS2_k127_5657849_0 Glycosyltransferase family 20 K00697,K13057,K20436 - 2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 609.0
TLS2_k127_5657849_1 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000001052 179.0
TLS2_k127_5657849_2 YCII-related domain K09780 - - 0.00000002205 63.0
TLS2_k127_5661949_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 470.0
TLS2_k127_5661949_1 AMP-binding enzyme C-terminal domain K00666 - - 0.00000000002243 66.0
TLS2_k127_5670931_0 Bacterial type II and III secretion system protein K02453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009636 295.0
TLS2_k127_567850_0 Maltogenic Amylase, C-terminal domain K05343 - 3.2.1.1,5.4.99.16 2.923e-279 878.0
TLS2_k127_567850_1 Phosphotransferase enzyme family K00700,K05343,K16146 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003247 293.0
TLS2_k127_567850_2 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 0.00000000000000000000000000000000000000000000000000000000000000000001909 239.0
TLS2_k127_5679720_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000009245 237.0
TLS2_k127_5679720_1 Redoxin - - - 0.000000000000000000000000000000000000000000000001663 180.0
TLS2_k127_5679720_2 Helix-turn-helix domain - - - 0.00000000000000000005986 92.0
TLS2_k127_5679779_0 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000776 475.0
TLS2_k127_5679779_1 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000007103 244.0
TLS2_k127_5679779_2 - - - - 0.00000000000000000000000002656 112.0
TLS2_k127_5679779_3 Mediates influx of magnesium ions K03284 - - 0.00000000000000000002763 95.0
TLS2_k127_5679779_4 Patatin-like phospholipase - - - 0.0000007174 62.0
TLS2_k127_5682299_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.333e-252 791.0
TLS2_k127_5682299_1 Cytochrome b(N-terminal)/b6/petB K00412 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 619.0
TLS2_k127_5682299_2 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 418.0
TLS2_k127_5682299_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001863 259.0
TLS2_k127_5682299_4 oxidoreductase activity, acting on diphenols and related substances as donors K00240,K03886 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000004146 238.0
TLS2_k127_5682299_5 cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000001465 226.0
TLS2_k127_5682299_6 PFAM Cytochrome c, class I K03889 - - 0.0000000000000000000000000000000000000000000000000000001216 214.0
TLS2_k127_5682299_7 polysaccharide catabolic process K01179 - 3.2.1.4 0.0000000000000000000000000000000001392 147.0
TLS2_k127_5684721_0 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003838 280.0
TLS2_k127_5684721_1 deacetylase - - - 0.0000000000000000000000000000000000000000003081 179.0
TLS2_k127_5684721_2 Wzy family polymerase, exosortase system type 1 associated - - - 0.00000000000000006908 83.0
TLS2_k127_5690416_0 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 468.0
TLS2_k127_5690416_1 Domain of unknown function (DUF4392) - - - 0.000000000000000000000001728 108.0
TLS2_k127_5691351_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 408.0
TLS2_k127_5691351_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002516 278.0
TLS2_k127_5691351_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000223 267.0
TLS2_k127_5695188_0 PFAM copper amine oxidase K00276 - 1.4.3.21 2.963e-283 884.0
TLS2_k127_5696785_0 Urease alpha-subunit, N-terminal domain K01428 - 3.5.1.5 7.884e-277 865.0
TLS2_k127_5696785_1 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004857 611.0
TLS2_k127_5696785_2 Belongs to the binding-protein-dependent transport system permease family K11960 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 398.0
TLS2_k127_5696785_3 Branched-chain amino acid transport system / permease component K11961 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 363.0
TLS2_k127_5696785_4 TIGRFAM ABC transporter, urea, ATP-binding protein, UrtD K11962 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004006 297.0
TLS2_k127_5696785_5 branched-chain amino acid transport K11963 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009249 255.0
TLS2_k127_5696785_6 Belongs to the urease gamma subunit family K01430 - 3.5.1.5 0.00000000000000000000000000000000000000000003893 163.0
TLS2_k127_5696785_7 ANTAR K07183,K22010 - - 0.0000000000000000000000000000000000000000006876 162.0
TLS2_k127_5696785_8 Belongs to the urease beta subunit family K01429 - 3.5.1.5 0.0000000000000000000000000000000000000005488 159.0
TLS2_k127_5702207_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 394.0
TLS2_k127_5702209_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008505 387.0
TLS2_k127_5703352_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 441.0
TLS2_k127_5703352_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000002455 232.0
TLS2_k127_5703352_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.0000000000000000000000000000000000000004832 153.0
TLS2_k127_5703352_3 PFAM YbbR family protein - - - 0.000000000000000000000000000000000001955 151.0
TLS2_k127_5703352_4 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000003478 125.0
TLS2_k127_5703377_0 transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 400.0
TLS2_k127_5703377_1 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000002978 73.0
TLS2_k127_5703631_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 2.06e-206 650.0
TLS2_k127_5703631_1 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 347.0
TLS2_k127_5703631_2 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000002109 260.0
TLS2_k127_5703631_3 Phosphoglycerate mutase family - - - 0.0000000000000000004868 94.0
TLS2_k127_5704151_0 histone H2A K63-linked ubiquitination K04771,K07003 - 3.4.21.107 0.00000000000000000006749 105.0
TLS2_k127_5704151_1 - - - - 0.0000000000000000008714 100.0
TLS2_k127_5704151_2 - - - - 0.0000000000324 76.0
TLS2_k127_5704151_3 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000371 57.0
TLS2_k127_5704151_4 Chromate resistance exported protein - - - 0.0003404 53.0
TLS2_k127_5704581_0 Belongs to the thiolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 432.0
TLS2_k127_5704581_1 Transporter associated domain K03699,K06189 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 332.0
TLS2_k127_5704581_3 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000001716 154.0
TLS2_k127_5704736_0 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 465.0
TLS2_k127_5704736_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003073 272.0
TLS2_k127_5705519_0 MutS domain I K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003247 522.0
TLS2_k127_5705519_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 406.0
TLS2_k127_5705519_2 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006761 387.0
TLS2_k127_5705519_3 Protein of unknown function (DUF512) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 370.0
TLS2_k127_5705519_4 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 356.0
TLS2_k127_5705519_5 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000008025 241.0
TLS2_k127_5705519_6 CDP-alcohol phosphatidyltransferase K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000001944 141.0
TLS2_k127_5705882_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004848 269.0
TLS2_k127_5705882_1 PFAM Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000001565 168.0
TLS2_k127_5709132_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008592 244.0
TLS2_k127_5716856_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 332.0
TLS2_k127_5719145_0 UvrD/REP helicase N-terminal domain K03656,K03657 GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 4.349e-208 669.0
TLS2_k127_5719145_1 regulation of pentose-phosphate shunt K14634 GO:0001666,GO:0002064,GO:0002065,GO:0002066,GO:0002831,GO:0002931,GO:0003674,GO:0003824,GO:0004083,GO:0004331,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005829,GO:0006003,GO:0006109,GO:0006110,GO:0006140,GO:0006282,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0007275,GO:0008150,GO:0008152,GO:0009314,GO:0009410,GO:0009628,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010035,GO:0010038,GO:0010212,GO:0010332,GO:0010506,GO:0010507,GO:0010562,GO:0010563,GO:0010604,GO:0010639,GO:0010660,GO:0010661,GO:0010662,GO:0010663,GO:0010665,GO:0010666,GO:0010675,GO:0010676,GO:0010677,GO:0010821,GO:0010823,GO:0010906,GO:0010941,GO:0010942,GO:0016020,GO:0016241,GO:0016242,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019219,GO:0019220,GO:0019222,GO:0019637,GO:0019867,GO:0030154,GO:0030388,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0030855,GO:0031090,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032025,GO:0032501,GO:0032502,GO:0033043,GO:0033554,GO:0033673,GO:0033674,GO:0034248,GO:0034416,GO:0035295,GO:0036293,GO:0036294,GO:0042221,GO:0042325,GO:0042326,GO:0042327,GO:0042578,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043069,GO:0043085,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043455,GO:0043456,GO:0043465,GO:0043467,GO:0043470,GO:0043471,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045739,GO:0045820,GO:0045912,GO:0045913,GO:0045934,GO:0045935,GO:0045936,GO:0045937,GO:0045980,GO:0048468,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048565,GO:0048583,GO:0048584,GO:0048731,GO:0048856,GO:0048869,GO:0050308,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0051338,GO:0051347,GO:0051348,GO:0051716,GO:0055123,GO:0060255,GO:0060429,GO:0060548,GO:0060575,GO:0060576,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0070482,GO:0070887,GO:0071241,GO:0071248,GO:0071279,GO:0071453,GO:0071456,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0098588,GO:0098805,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901003,GO:1901135,GO:1901214,GO:1901215,GO:1901524,GO:1901525,GO:1902031,GO:1902145,GO:1902151,GO:1902153,GO:1902688,GO:1902689,GO:1903146,GO:1903147,GO:1903299,GO:1903301,GO:1903578,GO:1903579,GO:1904023,GO:1904024,GO:2000377,GO:2000378,GO:2001020,GO:2001022,GO:2001169,GO:2001170 3.1.3.46 0.0000000000000000000000000000000000009297 146.0
TLS2_k127_5719145_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000001486 114.0
TLS2_k127_5719174_0 Belongs to the type-B carboxylesterase lipase family K03929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006872 394.0
TLS2_k127_5719174_1 lactoylglutathione lyase activity K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000002541 164.0
TLS2_k127_5719604_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695,K03696 - - 0.0 1121.0
TLS2_k127_5719604_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009457 556.0
TLS2_k127_5719604_10 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000248 220.0
TLS2_k127_5719604_11 PFAM Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000000000008582 206.0
TLS2_k127_5719604_12 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000003121 194.0
TLS2_k127_5719604_13 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.00000000000000000000000000000000000000000000000005379 192.0
TLS2_k127_5719604_14 Cupin domain K11312 - - 0.00000000000000000000000000000001087 130.0
TLS2_k127_5719604_2 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 483.0
TLS2_k127_5719604_3 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004752 411.0
TLS2_k127_5719604_4 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 330.0
TLS2_k127_5719604_5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007052 294.0
TLS2_k127_5719604_6 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002374 275.0
TLS2_k127_5719604_7 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002941 275.0
TLS2_k127_5719604_8 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004422 258.0
TLS2_k127_5719604_9 ATPases associated with a variety of cellular activities K01995 - - 0.00000000000000000000000000000000000000000000000000000000000415 227.0
TLS2_k127_5721822_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 318.0
TLS2_k127_5721822_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001018 280.0
TLS2_k127_5721822_2 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000002627 130.0
TLS2_k127_5721822_3 COG0433 Predicted ATPase - - - 0.0000000009617 66.0
TLS2_k127_5721822_4 - - - - 0.000000001915 61.0
TLS2_k127_5721822_5 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.00003648 51.0
TLS2_k127_5723563_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 510.0
TLS2_k127_5723563_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000143 188.0
TLS2_k127_5723563_3 DinB superfamily - - - 0.0005123 43.0
TLS2_k127_5726432_0 S-adenosylmethionine synthetase, C-terminal domain K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003313 565.0
TLS2_k127_5726432_1 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 334.0
TLS2_k127_5729346_0 CoA-binding domain protein - - - 1.906e-208 674.0
TLS2_k127_5729346_1 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 526.0
TLS2_k127_5729346_2 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001689 247.0
TLS2_k127_5729346_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.000000000000000000000000000000001618 149.0
TLS2_k127_5729346_4 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000007955 121.0
TLS2_k127_5730470_0 TRAP transporter, 4TM 12TM fusion protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 513.0
TLS2_k127_5730470_1 PFAM Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 295.0
TLS2_k127_5730470_2 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000122 244.0
TLS2_k127_5730470_3 AMP-binding enzyme C-terminal domain K00666,K18687 - 6.2.1.41 0.000008338 49.0
TLS2_k127_5730569_0 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008807 326.0
TLS2_k127_5730569_1 TIGRFAM TRAP dicarboxylate transporter, DctP subunit - - - 0.00000000000000000000000000000000000000000000000000001082 198.0
TLS2_k127_5730569_2 Amidase - - - 0.000000000000000000000007059 103.0
TLS2_k127_5730569_3 TRAP transporter, DctQ-like membrane protein - - - 0.0000000000000000000747 95.0
TLS2_k127_5734748_0 Histidine kinase K03407,K03412 - 2.7.13.3,3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 477.0
TLS2_k127_5734748_1 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000001808 58.0
TLS2_k127_5739072_0 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 342.0
TLS2_k127_5739072_1 Predicted membrane protein (DUF2214) K08983 - - 0.00000000000000000000000000004515 132.0
TLS2_k127_5740412_0 AIR synthase related protein, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 555.0
TLS2_k127_5740412_1 Histone deacetylase domain K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006152 375.0
TLS2_k127_5740412_2 Luciferase-like monooxygenase K15854 - 1.14.14.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 357.0
TLS2_k127_5740412_3 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000003903 184.0
TLS2_k127_5740412_4 serine-type endopeptidase activity - - - 0.0000000000000000000000000000000000926 143.0
TLS2_k127_5740412_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02045,K02049,K02068,K02071,K06857,K10112,K11072 - 3.6.3.25,3.6.3.30,3.6.3.31,3.6.3.55 0.000000000000000000001563 99.0
TLS2_k127_5740412_6 replication factor c K02341 - 2.7.7.7 0.000000000000007189 89.0
TLS2_k127_5740412_7 protein kinase activity - - - 0.000000000001408 81.0
TLS2_k127_5740412_8 membrane - - - 0.00000000000302 68.0
TLS2_k127_5740412_9 - K09794 - - 0.0004214 50.0
TLS2_k127_5746996_0 PFAM ABC transporter related K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 347.0
TLS2_k127_5746996_1 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000001345 153.0
TLS2_k127_5746996_2 Biotin-requiring enzyme - - - 0.000000000000000000001087 105.0
TLS2_k127_5747703_0 Hydantoinase/oxoprolinase - - - 4.089e-198 646.0
TLS2_k127_5747703_1 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000003062 126.0
TLS2_k127_5748841_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000008097 183.0
TLS2_k127_5748841_1 PFAM molybdopterin biosynthesis MoaE protein K03635,K21142 - 2.8.1.12 0.00000000000000000000000000000000000000000002652 171.0
TLS2_k127_5748841_2 Belongs to the HesB IscA family K13628,K15724 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564 - 0.000000000000000000000000000007953 123.0
TLS2_k127_5748841_3 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000004093 72.0
TLS2_k127_5752134_0 response regulator K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009133 496.0
TLS2_k127_5752134_1 histidine kinase HAMP region domain protein - - - 0.00000000000000000000006187 100.0
TLS2_k127_5752393_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 5.892e-200 651.0
TLS2_k127_5752393_1 [glutamate-ammonia-ligase] adenylyltransferase activity K00982 GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 608.0
TLS2_k127_5752393_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008324 495.0
TLS2_k127_5752393_3 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 489.0
TLS2_k127_5752393_4 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008004 364.0
TLS2_k127_5752393_5 TIGRFAM Na Pi-cotransporter II-related protein K03324 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000357 352.0
TLS2_k127_5752393_6 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000001041 181.0
TLS2_k127_5752393_7 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.00000000000000000000005995 114.0
TLS2_k127_5752393_8 PFAM ThiamineS - - - 0.0003668 48.0
TLS2_k127_5753723_0 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 574.0
TLS2_k127_5753723_1 endonuclease III K00558,K01962,K01963,K03575 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.37,2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000008038 269.0
TLS2_k127_5753723_2 racemase activity, acting on amino acids and derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003507 259.0
TLS2_k127_5753723_3 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000004071 227.0
TLS2_k127_5753723_4 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000007869 219.0
TLS2_k127_5753723_5 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000002086 120.0
TLS2_k127_5753723_6 Belongs to the Dps family K04047 - - 0.0000002356 53.0
TLS2_k127_5766885_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000005256 248.0
TLS2_k127_5766885_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000004712 214.0
TLS2_k127_5766885_2 Methionine biosynthesis protein MetW - - - 0.000007525 49.0
TLS2_k127_57802_0 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009979 364.0
TLS2_k127_57802_1 Regulates arginine biosynthesis genes K03402 - - 0.0000000000000003966 86.0
TLS2_k127_578331_0 COG0044 Dihydroorotase and related cyclic amidohydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 378.0
TLS2_k127_5783883_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 8.4e-222 700.0
TLS2_k127_5783883_1 Amino-transferase class IV K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005098 495.0
TLS2_k127_5783883_10 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000001039 210.0
TLS2_k127_5783883_11 Enoyl-CoA hydratase K16425 GO:0003674,GO:0003824,GO:0004300,GO:0016829,GO:0016835,GO:0016836 - 0.0000000000000000000000000000000000000003761 159.0
TLS2_k127_5783883_12 Scavenger mRNA decapping enzyme C-term binding - - - 0.000000000000000000000000000000000000006493 151.0
TLS2_k127_5783883_13 UTRA K03710 - - 0.000000000000000000000000000000000803 140.0
TLS2_k127_5783883_14 - - - - 0.00000000000000000000000000001648 120.0
TLS2_k127_5783883_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006992 424.0
TLS2_k127_5783883_3 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004903 417.0
TLS2_k127_5783883_4 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 404.0
TLS2_k127_5783883_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 404.0
TLS2_k127_5783883_6 Branched-chain amino acid ATP-binding cassette transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 372.0
TLS2_k127_5783883_7 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009511 308.0
TLS2_k127_5783883_8 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006706 308.0
TLS2_k127_5783883_9 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000002427 231.0
TLS2_k127_5787939_0 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 355.0
TLS2_k127_5787939_1 - - - - 0.000000000000000000000000000001764 126.0
TLS2_k127_5798782_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000002224 153.0
TLS2_k127_5798782_2 rRNA (guanine-N2-)-methyltransferase activity - - - 0.000000000000000001397 97.0
TLS2_k127_5799631_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 575.0
TLS2_k127_5799631_1 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009017 387.0
TLS2_k127_5799631_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 336.0
TLS2_k127_5799631_3 C4-type zinc ribbon domain K07164,K22391 - 3.5.4.16 0.0000000000000000000000000002894 123.0
TLS2_k127_5799631_4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000001739 114.0
TLS2_k127_5811384_0 Disulphide bond corrector protein DsbC K04084 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 324.0
TLS2_k127_5811384_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 287.0
TLS2_k127_5811384_2 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002428 247.0
TLS2_k127_5811384_3 Histidine kinase-like ATPases K07636,K07768 - 2.7.13.3 0.00000000003078 64.0
TLS2_k127_5812845_0 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 331.0
TLS2_k127_5812845_1 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000007433 175.0
TLS2_k127_5821817_0 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000002855 159.0
TLS2_k127_5821817_1 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000001393 141.0
TLS2_k127_5828010_0 PFAM ABC-type transporter, integral membrane subunit K05778 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 439.0
TLS2_k127_5828010_1 transport system, ATPase component K05779 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001616 275.0
TLS2_k127_5828010_2 SPTR PIN domain protein like protein - - - 0.000000000000000000000001781 107.0
TLS2_k127_5828010_3 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.00000000000000000000003534 103.0
TLS2_k127_5828010_5 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0007747 43.0
TLS2_k127_5834940_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001044 251.0
TLS2_k127_5834940_1 Uncharacterised nucleotidyltransferase - - - 0.00000000000000000000000000000000000000000000000000001232 203.0
TLS2_k127_5841739_0 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 479.0
TLS2_k127_5841739_1 PFAM NADH Ubiquinone plastoquinone (complex I) K05568,K12141 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 398.0
TLS2_k127_5841739_2 Na H antiporter, MnhB K05566 - - 0.0000000000000000000000000000000000001637 152.0
TLS2_k127_5841739_3 Proton-conducting membrane transporter - - - 0.00000000000000000000000000000000003071 147.0
TLS2_k127_5841739_4 Domain related to MnhB subunit of Na+/H+ antiporter - - - 0.000000000000000000000000002441 117.0
TLS2_k127_5841739_5 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.0000000000000000000000001914 116.0
TLS2_k127_5841739_6 Na+/H+ ion antiporter subunit K05569 - - 0.0000000000000000000001228 104.0
TLS2_k127_5841739_7 monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.0000000000000004348 87.0
TLS2_k127_5841739_8 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.000000000000009649 84.0
TLS2_k127_5845406_0 N-methylhydantoinase B acetone carboxylase, alpha subunit K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 517.0
TLS2_k127_5845406_1 Hydantoinase/oxoprolinase N-terminal region K01469,K01473 - 3.5.2.14,3.5.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005188 471.0
TLS2_k127_5853450_0 Domain of Unknown Function (DUF748) - - - 0.000000000003952 79.0
TLS2_k127_5853450_1 PFAM Cytochrome P450 - - - 0.0000000001664 74.0
TLS2_k127_585366_0 Polysaccharide deacetylase - - - 0.000001554 52.0
TLS2_k127_585366_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00001332 55.0
TLS2_k127_585366_2 Lysin motif - - - 0.0002885 53.0
TLS2_k127_5853997_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 3.95e-321 1004.0
TLS2_k127_5853997_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 433.0
TLS2_k127_5853997_2 Thioesterase superfamily - - - 0.000000000000000005171 89.0
TLS2_k127_5854187_0 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 517.0
TLS2_k127_5854187_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006467 387.0
TLS2_k127_5855957_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 515.0
TLS2_k127_5855957_1 Oxidoreductase FAD NAD(P)-binding domain protein K00351 - 1.6.5.8 0.0000000000000000004922 94.0
TLS2_k127_5861980_0 TIGRFAM diguanylate cyclase (GGDEF) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 353.0
TLS2_k127_5861980_1 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005163 280.0
TLS2_k127_5861980_2 Sucrose-6F-phosphate phosphohydrolase - - - 0.00000000000006696 77.0
TLS2_k127_5862533_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000001169 148.0
TLS2_k127_5874325_0 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000007604 230.0
TLS2_k127_5874325_2 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - 0.0000000000000000000000000000000000005835 142.0
TLS2_k127_5874325_3 Selenoprotein B, glycine betaine sarcosine D-proline reductase family K10672 - 1.21.4.2 0.0000000000000000000000003196 106.0
TLS2_k127_5874325_4 cell septum assembly K02487,K06596,K08372 - - 0.00000000000000005306 93.0
TLS2_k127_5874325_5 DsbA oxidoreductase - - - 0.0000000000000005548 85.0
TLS2_k127_5874325_6 Belongs to the ILVD EDD family K01687 - 4.2.1.9 0.0000000002039 64.0
TLS2_k127_5894572_0 Tryptophan halogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 383.0
TLS2_k127_5894572_1 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000001078 164.0
TLS2_k127_5894572_2 Luciferase-like monooxygenase - - - 0.0000000000000004479 80.0
TLS2_k127_5904017_0 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 345.0
TLS2_k127_5904017_1 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008886 319.0
TLS2_k127_5904017_2 N-terminal TM domain of oligopeptide transport permease C K02034,K15582 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 310.0
TLS2_k127_5904017_3 Ketopantoate reductase PanE/ApbA C terminal - - - 0.000000000000000000000000000000000000000000000000000002349 200.0
TLS2_k127_5904984_0 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005592 402.0
TLS2_k127_5906070_0 TrkA-N domain K03455,K10716 - - 1.244e-199 642.0
TLS2_k127_5906070_1 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 592.0
TLS2_k127_5906070_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000000000000005674 182.0
TLS2_k127_5906070_11 PFAM Phosphoribosyltransferase - - - 0.0000000000000000000000000000000000018 143.0
TLS2_k127_5906070_12 Preprotein translocase SecG subunit K03075 - - 0.000000000000000004088 90.0
TLS2_k127_5906070_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005494 462.0
TLS2_k127_5906070_3 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000427 423.0
TLS2_k127_5906070_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 421.0
TLS2_k127_5906070_5 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005006 393.0
TLS2_k127_5906070_6 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006594 383.0
TLS2_k127_5906070_7 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 379.0
TLS2_k127_5906070_8 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001148 279.0
TLS2_k127_5906070_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000002326 244.0
TLS2_k127_5908066_0 SPFH domain Band 7 family protein 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006676 355.0
TLS2_k127_5908066_1 Transcription factor zinc-finger - - - 0.000000000000000000000000000000000000000005737 164.0
TLS2_k127_5908066_2 ATP dependent DNA ligase domain protein K01971 - 6.5.1.1 0.00000000000000002791 82.0
TLS2_k127_5908183_0 S-adenosylmethionine synthetase (AdoMet synthetase) K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 385.0
TLS2_k127_5908183_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000005604 199.0
TLS2_k127_5908183_2 Putative nucleotidyltransferase substrate binding domain - - - 0.000000000000000000000000001019 119.0
TLS2_k127_5908183_3 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.00003376 53.0
TLS2_k127_5929607_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1026.0
TLS2_k127_5929607_1 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 508.0
TLS2_k127_5929607_2 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 317.0
TLS2_k127_5929607_3 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000001468 272.0
TLS2_k127_5929607_4 Permease, YjgP YjgQ - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002857 288.0
TLS2_k127_5929607_5 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000000000000000000000000000001707 166.0
TLS2_k127_5929607_6 UPF0182 protein K09118 - - 0.00002726 49.0
TLS2_k127_5934687_0 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003316 258.0
TLS2_k127_5934687_1 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000003401 204.0
TLS2_k127_5954806_0 Amidohydrolase family K01464 - 3.5.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004243 570.0
TLS2_k127_5954806_1 Penicillin amidase K01434 - 3.5.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 574.0
TLS2_k127_5954806_2 alcohol dehydrogenase (NAD) activity K00001,K00121,K02267,K13980,K18857 GO:0000302,GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009410,GO:0009413,GO:0009414,GO:0009415,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009737,GO:0009743,GO:0009744,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0014074,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0031000,GO:0032355,GO:0033993,GO:0034285,GO:0036270,GO:0036293,GO:0042221,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043279,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046686,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065007,GO:0070482,GO:0071944,GO:0080134,GO:0080135,GO:0097305,GO:1900037,GO:1900039,GO:1901698,GO:1901700 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006912 449.0
TLS2_k127_5954806_3 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 374.0
TLS2_k127_5954806_4 HMGL-like K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007255 353.0
TLS2_k127_5954806_5 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000004444 210.0
TLS2_k127_5956753_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 3.031e-214 684.0
TLS2_k127_5956856_0 PFAM Hydantoinase B oxoprolinase K01469,K01474 - 3.5.2.14,3.5.2.9 3.259e-198 630.0
TLS2_k127_5956856_1 Redoxin - - - 0.00000768 53.0
TLS2_k127_5956856_2 Peroxiredoxin K03564 - 1.11.1.15 0.00006735 46.0
TLS2_k127_5965089_0 FMN-dependent dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 451.0
TLS2_k127_5965089_1 Peptidyl-prolyl cis-trans isomerase K01802,K03772,K03773 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003697 272.0
TLS2_k127_5965089_2 - - - - 0.000000000000000000000000000000000000000000000005277 181.0
TLS2_k127_5965089_3 Competence-damaged protein - - - 0.0000000000582 64.0
TLS2_k127_5972803_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000002682 231.0
TLS2_k127_5972803_1 Psort location Cytoplasmic, score 9.26 K00059 - 1.1.1.100 0.00000000000000000000000000000008644 135.0
TLS2_k127_5972803_2 lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000000000000000006116 112.0
TLS2_k127_5972803_3 positive regulation of growth - - - 0.0000000000000001803 81.0
TLS2_k127_5972803_4 PIN domain - - - 0.0000000004745 62.0
TLS2_k127_597986_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 522.0
TLS2_k127_597986_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 313.0
TLS2_k127_597986_2 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004268 260.0
TLS2_k127_597986_3 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000001472 241.0
TLS2_k127_597986_4 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000001329 197.0
TLS2_k127_5983150_0 mannose-ethanolamine phosphotransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000539 271.0
TLS2_k127_5983150_1 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000007717 248.0
TLS2_k127_5983150_2 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000002021 219.0
TLS2_k127_5983150_3 cyclic nucleotide-binding - - - 0.00000000000000000000000000000000000000000000005812 177.0
TLS2_k127_5983150_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000001002 151.0
TLS2_k127_5983150_5 Cold shock K03704 - - 0.0000000000000000001933 90.0
TLS2_k127_5983150_6 type I restriction enzyme, R K01153 - 3.1.21.3 0.000001387 60.0
TLS2_k127_5983150_7 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.00006738 54.0
TLS2_k127_5983950_0 PFAM AMP-dependent synthetase and ligase K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 285.0
TLS2_k127_5983950_1 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029,K10002 - - 0.000000000000000006451 85.0
TLS2_k127_5983950_2 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.000000000000000008889 94.0
TLS2_k127_5985294_0 KR domain K00065 - 1.1.1.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 355.0
TLS2_k127_5985294_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000001145 271.0
TLS2_k127_5985294_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000003871 247.0
TLS2_k127_5985294_3 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000002182 150.0
TLS2_k127_5985294_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - - 0.000000000000000000000006191 119.0
TLS2_k127_5985294_5 Phosphopantetheine attachment site - - - 0.000199 53.0
TLS2_k127_5998001_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009061 364.0
TLS2_k127_5998001_1 Sulfite exporter TauE/SafE - - - 0.00000000000000000000000000000000000000000000001934 180.0
TLS2_k127_6002802_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 1.644e-256 812.0
TLS2_k127_6002802_1 PFAM 6-phosphogluconate dehydrogenase NAD-binding protein - - - 0.000000000000000000000000000000000000000000000000000001133 204.0
TLS2_k127_6011503_0 COG1233 Phytoene dehydrogenase and related proteins - - - 2.378e-230 725.0
TLS2_k127_6011503_1 Sugar (and other) transporter K03446 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 382.0
TLS2_k127_6011503_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.0000000000000000000000000000000000007694 140.0
TLS2_k127_6011503_3 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.000000000000000000000000000114 117.0
TLS2_k127_6030522_0 FeS assembly protein SufB K09014 - - 2.822e-239 750.0
TLS2_k127_6030522_1 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 579.0
TLS2_k127_6030522_2 TIGRFAM FeS assembly ATPase SufC K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 373.0
TLS2_k127_6030522_3 FeS assembly protein SufD K07033,K09015 GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007238 368.0
TLS2_k127_6030522_4 NifU-like N terminal domain K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.00000000000000000000000000000000005337 154.0
TLS2_k127_6037460_0 acetyl-coa acetyltransferase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004503 393.0
TLS2_k127_6037460_1 Belongs to the peptidase M16 family K07263 - - 0.00000000000000000000000000000000000000000000000000000000002386 224.0
TLS2_k127_6037460_2 PFAM Peptidase M16 inactive domain - - - 0.0000000000000000000000000000000000000000000000000000000000518 233.0
TLS2_k127_6037460_3 Belongs to the helicase family. UvrD subfamily - - - 0.0000000000000000000000000000000000000000000000000000000004198 220.0
TLS2_k127_6037460_4 KR domain - - - 0.000000000000000000000000000000000000000000000000001205 190.0
TLS2_k127_6037460_5 hydrolase (HAD superfamily) K01560,K07025,K08723 - 3.1.3.5,3.8.1.2 0.000000000000000000000000000000000000000000001561 186.0
TLS2_k127_6037460_6 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000002416 135.0
TLS2_k127_6037460_7 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000002062 126.0
TLS2_k127_6100731_0 oxidation-reduction process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005993 271.0
TLS2_k127_6100731_1 3'-5' exonuclease activity K03547 - - 0.0000000000000000000000000000000000000000000001222 181.0
TLS2_k127_6100731_2 ribonucleoside-diphosphate reductase activity K07735 - - 0.000000000000000000000000000000000000000000004612 181.0
TLS2_k127_6128321_0 glucose sorbosone - - - 0.0000000000000000000000003579 111.0
TLS2_k127_6128321_1 protein import - - - 0.00000000000000000000003415 114.0
TLS2_k127_6128321_2 Acetoin utilization protein K04767 - - 0.000000000000000003785 89.0
TLS2_k127_6146715_0 iron dependent repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007424 318.0
TLS2_k127_6146715_1 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001856 250.0
TLS2_k127_6146715_10 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000007859 70.0
TLS2_k127_6146715_11 ABC transporter substrate binding protein - - - 0.000000001024 60.0
TLS2_k127_6146715_2 PFAM ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004355 254.0
TLS2_k127_6146715_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000007736 244.0
TLS2_k127_6146715_4 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000397 153.0
TLS2_k127_6146715_5 - - - - 0.000000000000000000000000000001853 137.0
TLS2_k127_6146715_6 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000004487 107.0
TLS2_k127_6146715_7 Branched-chain amino acid transport system permease K01998 - - 0.00000000000000000006103 93.0
TLS2_k127_6146715_8 Methyltransferase small domain - - - 0.0000000000000000001438 102.0
TLS2_k127_6146715_9 iron dependent repressor K02003,K02565,K07058,K15545 - - 0.000000000000002701 87.0
TLS2_k127_6149289_0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652,K12673 - 2.2.1.6,2.5.1.66 0.00000000000000000000000000000000000000001049 159.0
TLS2_k127_6149289_1 Thioredoxin domain - - - 0.0000000000000000000000000000000004082 136.0
TLS2_k127_6149289_2 Thioredoxin domain - - - 0.00000000000000000001793 92.0
TLS2_k127_6149289_3 PFAM AIG2-like - - - 0.0000000005284 68.0
TLS2_k127_61742_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 453.0
TLS2_k127_61742_1 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003952 376.0
TLS2_k127_61742_2 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 335.0
TLS2_k127_61742_3 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002831 320.0
TLS2_k127_61742_4 Binding-protein-dependent transport system inner membrane component - - - 0.000000000002716 66.0
TLS2_k127_6184675_0 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002394 394.0
TLS2_k127_6184675_1 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 312.0
TLS2_k127_6184675_2 Membrane protein, TerC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004223 301.0
TLS2_k127_6184675_3 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001115 284.0
TLS2_k127_6184675_4 Belongs to the peptidase S51 family K05995 - 3.4.13.21 0.00000000000000000000000000000000000000002445 163.0
TLS2_k127_6184675_5 Haloacid dehalogenase-like hydrolase K01101 - 3.1.3.41 0.000000000000000000000000000000000001045 149.0
TLS2_k127_6184675_6 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000002283 95.0
TLS2_k127_6185977_0 DNA helicase K03654 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008953 438.0
TLS2_k127_6185977_1 monooxygenase activity K00688,K15760,K16157,K16242,K18223,K22353,K22357 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494 1.14.13.227,1.14.13.236,1.14.13.25,1.14.13.69,2.4.1.1 0.00000008931 60.0
TLS2_k127_6199523_0 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000005606 168.0
TLS2_k127_6199523_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000005125 129.0
TLS2_k127_6199523_2 Major Facilitator Superfamily - - - 0.00000000001238 72.0
TLS2_k127_6203124_0 Flavoprotein involved in K transport K03379 - 1.14.13.22 7.676e-251 785.0
TLS2_k127_6203124_1 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003475 528.0
TLS2_k127_6203124_2 COG0402 Cytosine deaminase and related metal-dependent hydrolases K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 385.0
TLS2_k127_6203124_3 alpha, beta - - - 0.000000000000000000000000000000000000000006342 164.0
TLS2_k127_6221012_0 Catalyzes the hydrolytic cleavage of imides that range from linear to heterocyclic and that include hydantoins, dihydropyrimidines, and phthalimides K01464 - 3.5.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000007961 261.0
TLS2_k127_6221012_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth - - - 0.000000000000000000000000000000000004888 143.0
TLS2_k127_622406_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 427.0
TLS2_k127_622406_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 369.0
TLS2_k127_623638_0 PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic K01886 - 6.1.1.18 7.592e-267 842.0
TLS2_k127_623638_1 ROK family K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 408.0
TLS2_k127_623638_2 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 347.0
TLS2_k127_623638_3 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008301 286.0
TLS2_k127_623638_4 Belongs to the type-B carboxylesterase lipase family K03929 - - 0.0000000000000000000000001686 110.0
TLS2_k127_623638_5 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000232 88.0
TLS2_k127_6240555_0 DegT/DnrJ/EryC1/StrS aminotransferase family K12452 - 1.17.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006133 389.0
TLS2_k127_6240555_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 347.0
TLS2_k127_6240555_2 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 314.0
TLS2_k127_6240555_3 Flavin reductase like domain - - - 0.00000000000000000000000000000000000004985 153.0
TLS2_k127_6240555_4 ATP-dependent protease La (LON) substrate-binding domain K01338,K07157 - 3.4.21.53 0.0000000000000000000000000000000000007087 149.0
TLS2_k127_6240555_5 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000000000009252 81.0
TLS2_k127_6240555_6 Carbamoyltransferase C-terminus K00612 - - 0.000000001414 66.0
TLS2_k127_6243904_0 Belongs to the UbiD family K16874 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 328.0
TLS2_k127_6243904_1 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000007567 184.0
TLS2_k127_6243904_2 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000009803 109.0
TLS2_k127_6250493_0 AMP-binding enzyme C-terminal domain K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 346.0
TLS2_k127_6258401_0 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 379.0
TLS2_k127_6258401_1 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000004126 210.0
TLS2_k127_6258401_2 Pfam Adenylate and Guanylate cyclase catalytic domain K01768,K07169,K11894 - 4.6.1.1 0.00000000000000000000003713 109.0
TLS2_k127_626393_0 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006013 622.0
TLS2_k127_626393_1 2-keto-3-deoxy-L-rhamnonate aldolase activity K02510,K12660 - 4.1.2.52,4.1.2.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001006 306.0
TLS2_k127_626393_2 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000001819 192.0
TLS2_k127_6274093_0 acyl-CoA transferases carnitine dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004155 458.0
TLS2_k127_6274093_1 Uncharacterised protein family (UPF0175) - - - 0.0000001553 64.0
TLS2_k127_6274891_0 Luciferase-like monooxygenase - - - 5.705e-198 629.0
TLS2_k127_6274891_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K08319 - 1.1.1.411 0.0000000000000000000000000000000000000000000000000000000000000000001238 243.0
TLS2_k127_6274891_2 Domain of unknown function (DUF4440) - - - 0.0000000000000000001321 94.0
TLS2_k127_6274891_3 Purine catabolism regulatory protein-like family K09684 - - 0.0000000005154 62.0
TLS2_k127_6274891_4 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.0003196 46.0
TLS2_k127_628457_0 competence protein COMEC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006617 273.0
TLS2_k127_628457_1 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000011 176.0
TLS2_k127_628457_2 Biotin carboxylase - - - 0.00000000000000000000000000000000002143 140.0
TLS2_k127_628457_3 Biotin carboxylase - - - 0.00000000002257 67.0
TLS2_k127_6295821_0 - - - - 1.278e-314 970.0
TLS2_k127_6295821_1 Thioesterase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009183 286.0
TLS2_k127_6295821_2 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.00000000000000000000000000000000000000000000006803 172.0
TLS2_k127_630734_0 TIM-barrel fold metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007796 266.0
TLS2_k127_630734_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000124 166.0
TLS2_k127_630734_2 Amidohydrolase K07045 - - 0.00000000000000000000000000004932 131.0
TLS2_k127_630734_3 Integrase core domain - - - 0.000000000000000562 82.0
TLS2_k127_630734_4 Belongs to the aldehyde dehydrogenase family K00154 - 1.2.1.68 0.0000000002945 62.0
TLS2_k127_6319605_0 PFAM ATP-binding region, ATPase domain protein K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000001059 192.0
TLS2_k127_6319605_1 response regulator, receiver - - - 0.00000000000000000003478 97.0
TLS2_k127_6319605_2 Nodulation protein S (NodS) - - - 0.0000000000001679 83.0
TLS2_k127_6319605_3 Isochorismatase family - - - 0.000009878 53.0
TLS2_k127_6355798_0 Ethanolamine utilization protein EutJ K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 334.0
TLS2_k127_6355798_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000004417 84.0
TLS2_k127_636793_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 428.0
TLS2_k127_636793_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000546 303.0
TLS2_k127_636793_2 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006277 274.0
TLS2_k127_636793_3 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000002197 141.0
TLS2_k127_642_0 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007575 326.0
TLS2_k127_642_1 - - - - 0.000000000000001376 79.0
TLS2_k127_646431_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 502.0
TLS2_k127_646431_1 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 314.0
TLS2_k127_646431_2 SMART PUA domain containing protein K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 301.0
TLS2_k127_646431_3 Belongs to the arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000004046 238.0
TLS2_k127_646431_4 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.00000000000000000000000000000000000000001389 164.0
TLS2_k127_646431_5 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000000000000000000000006402 153.0
TLS2_k127_646431_6 Methyltransferase domain - - - 0.000000000000000000000000003724 128.0
TLS2_k127_651651_0 ATPases associated with a variety of cellular activities K01996,K11958 - - 0.0000000000000000000000000000000000000000000000000000000000000008429 226.0
TLS2_k127_651651_1 PFAM ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000005181 234.0
TLS2_k127_651651_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000001277 201.0
TLS2_k127_651651_3 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000001837 172.0
TLS2_k127_651651_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000001815 126.0
TLS2_k127_6547600_0 Hsp70 protein K04043,K04044 - - 2.656e-211 673.0
TLS2_k127_6547600_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 551.0
TLS2_k127_6547600_10 DnaJ molecular chaperone homology domain K04082 - - 0.0000000000000000000000001084 115.0
TLS2_k127_6547600_11 iron-sulfur cluster assembly - GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772 - 0.0000000000000000000000002713 112.0
TLS2_k127_6547600_12 FeS cluster assembly scaffold protein NifU K04488 - - 0.0000000000000000000000004274 112.0
TLS2_k127_6547600_13 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE - - - 0.0000000000000000001184 95.0
TLS2_k127_6547600_14 TPR Domain containing protein K12600 - - 0.00000000000000003292 96.0
TLS2_k127_6547600_15 von Willebrand factor, type A - - - 0.00000000000000008506 96.0
TLS2_k127_6547600_2 von Willebrand factor, type A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 556.0
TLS2_k127_6547600_3 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006594 449.0
TLS2_k127_6547600_4 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000007023 257.0
TLS2_k127_6547600_5 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.00000000000000000000000000000000000000000000000000000000000001695 218.0
TLS2_k127_6547600_6 serine acetyltransferase K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000006728 170.0
TLS2_k127_6547600_7 Transcriptional regulator - - - 0.0000000000000000000000000000000001994 137.0
TLS2_k127_6547600_8 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.000000000000000000000000000005195 138.0
TLS2_k127_6547600_9 Belongs to the HesB IscA family K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:1901564 - 0.000000000000000000000000000007585 124.0
TLS2_k127_6548132_0 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 392.0
TLS2_k127_6548132_1 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 385.0
TLS2_k127_6548132_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004197 354.0
TLS2_k127_6548132_3 CHAD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000175 258.0
TLS2_k127_6548132_4 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000009221 246.0
TLS2_k127_6548132_5 abc-type fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.000000000000000000000000000000000000000000000000000000000002304 224.0
TLS2_k127_6548132_6 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.000000000000000000000000000000000000000000000000001851 191.0
TLS2_k127_6548132_7 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.00000000000000000000000000000000000000000001218 165.0
TLS2_k127_6548132_8 NUDIX domain - - - 0.000000000000000000000000000000000000001894 158.0
TLS2_k127_6548132_9 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000000004256 132.0
TLS2_k127_6563658_0 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004983 378.0
TLS2_k127_6563658_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000002433 187.0
TLS2_k127_6563658_2 multidrug resistance K15549 GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072348,GO:1901474,GO:1901682,GO:1902599 - 0.000000000000000000000000000000000000000000000001015 185.0
TLS2_k127_6564173_0 Bacterial extracellular solute-binding protein K05813 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005295 533.0
TLS2_k127_6564173_1 Belongs to the mandelate racemase muconate lactonizing enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004427 434.0
TLS2_k127_6564173_10 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000226 216.0
TLS2_k127_6564173_11 FGGY family of carbohydrate kinases, N-terminal domain K00854 - 2.7.1.17 0.000000000000000000000000000000000228 138.0
TLS2_k127_6564173_12 Isochorismatase family K13995 - 3.5.1.107 0.000000000009798 78.0
TLS2_k127_6564173_2 transmembrane transport K02025,K05814,K15771 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004914 384.0
TLS2_k127_6564173_3 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005913 384.0
TLS2_k127_6564173_4 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001787 269.0
TLS2_k127_6564173_5 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003629 286.0
TLS2_k127_6564173_6 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001119 260.0
TLS2_k127_6564173_7 Receptor family ligand binding region family protein 22 K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001969 262.0
TLS2_k127_6564173_8 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005786 265.0
TLS2_k127_6564173_9 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000002785 248.0
TLS2_k127_6564634_0 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001866 268.0
TLS2_k127_6564634_1 Peptidase dimerisation domain - - - 0.00001934 48.0
TLS2_k127_6564663_0 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002779 252.0
TLS2_k127_6564663_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000007735 117.0
TLS2_k127_6564663_2 Serine aminopeptidase, S33 - - - 0.0001545 47.0
TLS2_k127_6573138_0 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007697 472.0
TLS2_k127_6573138_1 PFAM Peptidase M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003959 291.0
TLS2_k127_6573138_2 NADH-Ubiquinone oxidoreductase (complex I), chain 5 K00341 - 1.6.5.3 0.000000000747 64.0
TLS2_k127_6574068_0 AAA domain K07133 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 401.0
TLS2_k127_6574068_1 TIR domain - - - 0.000000000000000000000000000009438 135.0
TLS2_k127_6577542_0 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K01856,K02549 - 4.2.1.113,5.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 317.0
TLS2_k127_6577542_1 NAD(P)-binding Rossmann-like domain K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000003259 245.0
TLS2_k127_65779_0 COG0402 Cytosine deaminase and related metal-dependent hydrolases K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000883 381.0
TLS2_k127_65779_1 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003072 269.0
TLS2_k127_65779_2 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000008893 168.0
TLS2_k127_65779_3 PFAM Phage derived protein Gp49-like (DUF891) - - - 0.00000002969 55.0
TLS2_k127_6578064_0 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001527 300.0
TLS2_k127_6579401_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1105.0
TLS2_k127_6579401_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 6.795e-284 890.0
TLS2_k127_6579401_10 DNA polymerase K02347 - - 0.000000000000000000000000000000000000004274 162.0
TLS2_k127_6579401_11 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.000000000000000000000000000000003941 132.0
TLS2_k127_6579401_12 GYD domain - - - 0.000000000000000000000000000001382 126.0
TLS2_k127_6579401_13 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000008128 105.0
TLS2_k127_6579401_14 COGs COG2905 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.00000000000000000000003571 104.0
TLS2_k127_6579401_15 Universal stress protein - - - 0.0000000000000000000006605 104.0
TLS2_k127_6579401_16 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000003396 85.0
TLS2_k127_6579401_17 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000004158 80.0
TLS2_k127_6579401_18 AMP binding - - - 0.0003713 51.0
TLS2_k127_6579401_19 AI-2E family transporter - - - 0.0008835 45.0
TLS2_k127_6579401_2 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 473.0
TLS2_k127_6579401_3 DNA polymerase X family K02347,K04477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007374 447.0
TLS2_k127_6579401_4 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 434.0
TLS2_k127_6579401_5 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002677 273.0
TLS2_k127_6579401_6 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001913 267.0
TLS2_k127_6579401_7 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.00000000000000000000000000000000000000000000000000000373 206.0
TLS2_k127_6579401_8 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000006594 190.0
TLS2_k127_6579401_9 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972,K02342,K04096,K12472 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 2.7.7.7,6.5.1.2 0.00000000000000000000000000000000000000000000001269 181.0
TLS2_k127_6581743_0 PFAM peptidase S9 prolyl oligopeptidase active site domain protein K01322,K01354 - 3.4.21.26,3.4.21.83 3.954e-197 631.0
TLS2_k127_6581743_1 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 448.0
TLS2_k127_6581743_2 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 384.0
TLS2_k127_6581743_3 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000000000005488 216.0
TLS2_k127_6581743_4 cheY-homologous receiver domain - - - 0.0000000000000000000000005206 121.0
TLS2_k127_6581743_5 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000014 117.0
TLS2_k127_6581743_6 Ketopantoate reductase PanE/ApbA C terminal - - - 0.00000001708 60.0
TLS2_k127_6583246_0 xanthine dehydrogenase activity K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000004676 190.0
TLS2_k127_6583246_1 intermembrane phospholipid transfer K07323 - - 0.00000000000000000000000000000000000003944 154.0
TLS2_k127_6583246_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000003466 149.0
TLS2_k127_6583246_3 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.00000000000000676 87.0
TLS2_k127_6585048_0 PFAM Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 486.0
TLS2_k127_6585048_1 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 455.0
TLS2_k127_6585048_10 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000002173 190.0
TLS2_k127_6585048_11 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000002212 176.0
TLS2_k127_6585048_12 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000415 68.0
TLS2_k127_6585048_2 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 370.0
TLS2_k127_6585048_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 350.0
TLS2_k127_6585048_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 347.0
TLS2_k127_6585048_5 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 334.0
TLS2_k127_6585048_6 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000139 275.0
TLS2_k127_6585048_7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005703 245.0
TLS2_k127_6585048_8 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000686 233.0
TLS2_k127_6585048_9 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000001782 202.0
TLS2_k127_6586266_0 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004666 481.0
TLS2_k127_6586266_1 DEAD-like helicases superfamily K07012 - - 0.0000000000000000000002275 109.0
TLS2_k127_6587209_0 40-residue YVTN family beta-propeller repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 368.0
TLS2_k127_6587209_1 PFAM Copper resistance D K07245 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 376.0
TLS2_k127_6587209_2 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008573 258.0
TLS2_k127_6587209_3 Fatty acid hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000007878 242.0
TLS2_k127_6587209_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07025 - - 0.000000000000000000000000000000000000000000000000008623 194.0
TLS2_k127_6587209_5 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K15778 - 5.4.2.2,5.4.2.8 0.0000000000000001237 81.0
TLS2_k127_6587209_6 Copper binding periplasmic protein CusF - - - 0.0001986 52.0
TLS2_k127_6589279_0 PFAM AMP-dependent synthetase and ligase K00666,K01897,K02182,K18661 - 6.2.1.3,6.2.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000562 433.0
TLS2_k127_6589279_1 Thioesterase superfamily - - - 0.000000000000000000000005744 118.0
TLS2_k127_6590205_0 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 425.0
TLS2_k127_6590205_1 N-methylhydantoinase A acetone carboxylase, beta subunit K01469,K01473 - 3.5.2.14,3.5.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 328.0
TLS2_k127_6590205_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000149 233.0
TLS2_k127_6592006_0 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 316.0
TLS2_k127_6592006_1 - - - - 0.0000000000000000000000125 108.0
TLS2_k127_6592006_2 - - - - 0.000000000001493 70.0
TLS2_k127_6592933_0 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000001705 186.0
TLS2_k127_6592933_1 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000007626 111.0
TLS2_k127_6592933_2 Universal stress protein family - - - 0.00000000000000000003194 96.0
TLS2_k127_6592933_3 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000005955 82.0
TLS2_k127_6595279_0 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007925 300.0
TLS2_k127_6595279_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006778 272.0
TLS2_k127_6595279_2 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000000000000000004341 107.0
TLS2_k127_6595279_3 Uncharacterized protein family UPF0016 - - - 0.0000000000000000001857 90.0
TLS2_k127_6595279_4 Ferredoxin - - - 0.00000000002351 68.0
TLS2_k127_6595500_0 PFAM transposase IS204 IS1001 IS1096 IS1165 family protein K07485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 469.0
TLS2_k127_6595500_1 Glycosyl hydrolase 36 superfamily, catalytic domain K00702 - 2.4.1.20 0.000000000000001986 78.0
TLS2_k127_659643_0 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000488 259.0
TLS2_k127_659643_1 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000002568 146.0
TLS2_k127_659643_2 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.000000000000000001109 90.0
TLS2_k127_659643_3 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000676 72.0
TLS2_k127_6600169_0 Branched-chain amino acid ATP-binding cassette transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 325.0
TLS2_k127_6600169_1 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003551 288.0
TLS2_k127_6600169_2 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005071 276.0
TLS2_k127_6600169_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000009928 228.0
TLS2_k127_6600169_4 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000000000000006901 211.0
TLS2_k127_6601095_0 Radical SAM - - - 1.794e-205 653.0
TLS2_k127_6601095_1 MMPL family K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 490.0
TLS2_k127_6601095_2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009436,GO:0009442,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042737,GO:0043436,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046483,GO:0046487,GO:0046700,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 325.0
TLS2_k127_6601095_3 Belongs to the malate synthase family K01638 - 2.3.3.9 0.000000000000000000000000000000000000000000000000000000000000000000001333 257.0
TLS2_k127_6601095_4 PFAM Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000001294 169.0
TLS2_k127_6601095_5 Glyoxalase-like domain K05606 - 5.1.99.1 0.0000000000000000000000000001804 129.0
TLS2_k127_6601095_6 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000003025 96.0
TLS2_k127_6601095_7 CopC domain - - - 0.0000000000000000001348 94.0
TLS2_k127_6601095_8 myo-inositol-1-phosphate synthase K01858 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 0.00000003876 55.0
TLS2_k127_6601095_9 - - - - 0.0006183 48.0
TLS2_k127_6603917_0 Acyl-CoA dehydrogenase, C-terminal domain K16047 - 1.14.14.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 346.0
TLS2_k127_6603917_1 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000000000000000000000000000000000008313 190.0
TLS2_k127_6603917_2 iron-sulfur cluster assembly K07400 - - 0.00000000000000000005648 90.0
TLS2_k127_6608650_0 PFAM glycosyl transferase family 35 K00688 - 2.4.1.1 1.263e-194 623.0
TLS2_k127_6608650_1 A circularly permuted ATPgrasp - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 569.0
TLS2_k127_6608650_10 A predicted alpha-helical domain with a conserved ER motif. - - - 0.00000000000000000000000000000000000003583 155.0
TLS2_k127_6608650_11 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 - 0.0000000000001243 78.0
TLS2_k127_6608650_12 - - - - 0.000000000001191 70.0
TLS2_k127_6608650_13 - - - - 0.000000000005175 69.0
TLS2_k127_6608650_2 Peptidase dimerisation domain K06016 - 3.5.1.6,3.5.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 411.0
TLS2_k127_6608650_3 Alpha/beta hydrolase family K07019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 294.0
TLS2_k127_6608650_4 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008209 274.0
TLS2_k127_6608650_5 transglutaminase-like - - - 0.0000000000000000000000000000000000000000000000000000000000401 219.0
TLS2_k127_6608650_6 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000003003 209.0
TLS2_k127_6608650_7 PFAM NUDIX domain - - - 0.000000000000000000000000000000000000000000000006954 177.0
TLS2_k127_6608650_8 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000002901 182.0
TLS2_k127_6608650_9 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000007146 173.0
TLS2_k127_6611618_0 Homogentisate 1,2-dioxygenase K00451 GO:0003674,GO:0003824,GO:0004411,GO:0006082,GO:0006520,GO:0006558,GO:0006559,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0019439,GO:0019752,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0051213,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222 1.13.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 505.0
TLS2_k127_6611618_1 PFAM Glyoxalase bleomycin resistance protein dioxygenase K00457 - 1.13.11.27 0.0000000000000000000000000009663 129.0
TLS2_k127_6625411_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 3.66e-248 780.0
TLS2_k127_6625411_1 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 391.0
TLS2_k127_6625411_2 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004225 327.0
TLS2_k127_6625411_3 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 297.0
TLS2_k127_6625411_4 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002469 244.0
TLS2_k127_6625411_5 Cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000001696 240.0
TLS2_k127_6625411_6 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.00000000000004125 76.0
TLS2_k127_6630805_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.062e-252 789.0
TLS2_k127_6630805_1 UvrD-like helicase C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001058 294.0
TLS2_k127_6637888_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 451.0
TLS2_k127_6637888_1 zinc transporter K07238 - - 0.0003677 49.0
TLS2_k127_6638541_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009616 396.0
TLS2_k127_6638541_1 Voltage gated chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 337.0
TLS2_k127_6638541_2 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001479 277.0
TLS2_k127_6638541_3 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000005292 194.0
TLS2_k127_6638541_4 transglycosylase associated protein - - - 0.00000000000000000009649 95.0
TLS2_k127_6640644_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1195.0
TLS2_k127_6640878_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 434.0
TLS2_k127_6640878_1 Two component, sigma54 specific, transcriptional regulator, Fis family K07712,K07714 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 385.0
TLS2_k127_6640878_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409,K03070 GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009056 360.0
TLS2_k127_6640878_3 PFAM ATP-binding region, ATPase domain protein K02668,K07708,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000009047 270.0
TLS2_k127_6640878_4 Peptidase family M23 K21471 GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000006895 222.0
TLS2_k127_6640878_5 Divergent polysaccharide deacetylase K09798 - - 0.0000000000000000000000000000000000007189 150.0
TLS2_k127_6640878_6 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000002817 70.0
TLS2_k127_6642583_0 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001495 283.0
TLS2_k127_6642583_1 'Cold-shock' DNA-binding domain K03704 - - 0.0000000000000002168 81.0
TLS2_k127_6642583_2 AhpC/TSA family - - - 0.0000008214 53.0
TLS2_k127_6644742_0 PFAM AAA ATPase central domain protein K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 507.0
TLS2_k127_6644742_1 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000163 189.0
TLS2_k127_6644742_2 quinone binding - - - 0.0000000000000000000000000000000001304 141.0
TLS2_k127_6647504_0 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 297.0
TLS2_k127_6647504_1 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004548 287.0
TLS2_k127_6647504_2 extracellular solute-binding protein, family 5 - - - 0.0000000000000000000000000000000000000000000000000000000000004908 231.0
TLS2_k127_6647504_3 UTRA K03710 - - 0.00000000000003726 80.0
TLS2_k127_6649314_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 544.0
TLS2_k127_6649314_1 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 320.0
TLS2_k127_6649314_2 Extracellular solute-binding protein, family 5 K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 327.0
TLS2_k127_6649314_3 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000007785 104.0
TLS2_k127_6649314_4 Hsp20/alpha crystallin family - - - 0.000000000000000000000008265 105.0
TLS2_k127_6652880_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000002262 251.0
TLS2_k127_6652880_1 Protein serine threonine phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000001892 211.0
TLS2_k127_6652880_2 Type VI secretion K11906 - - 0.0005096 49.0
TLS2_k127_6656539_0 Amidase K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006628 379.0
TLS2_k127_6656539_1 of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000489 134.0
TLS2_k127_6656539_2 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0000002869 55.0
TLS2_k127_6656539_3 PIN domain - - - 0.0007801 47.0
TLS2_k127_6656709_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 1.278e-201 646.0
TLS2_k127_6656709_1 serine-type endopeptidase activity K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 304.0
TLS2_k127_6656709_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002232 275.0
TLS2_k127_6656709_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000003764 244.0
TLS2_k127_6666624_0 Hydantoinase/oxoprolinase K01469,K01473 - 3.5.2.14,3.5.2.9 9.564e-294 919.0
TLS2_k127_6666624_1 Hydantoinase B/oxoprolinase - - - 7.323e-259 843.0
TLS2_k127_6666624_10 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002875 341.0
TLS2_k127_6666624_11 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 336.0
TLS2_k127_6666624_12 Maleate cis-trans isomerase K01799 - 5.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004951 313.0
TLS2_k127_6666624_13 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 294.0
TLS2_k127_6666624_14 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 292.0
TLS2_k127_6666624_15 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000007292 238.0
TLS2_k127_6666624_16 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000002658 225.0
TLS2_k127_6666624_17 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000007223 229.0
TLS2_k127_6666624_18 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000000003067 214.0
TLS2_k127_6666624_19 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000134 207.0
TLS2_k127_6666624_2 Periplasmic binding protein domain K01999 - - 7.612e-194 614.0
TLS2_k127_6666624_20 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000001967 207.0
TLS2_k127_6666624_21 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000102 204.0
TLS2_k127_6666624_22 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000005626 194.0
TLS2_k127_6666624_23 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000001891 168.0
TLS2_k127_6666624_24 Enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000003021 183.0
TLS2_k127_6666624_25 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000002266 156.0
TLS2_k127_6666624_26 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000002634 144.0
TLS2_k127_6666624_27 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000000000006697 115.0
TLS2_k127_6666624_28 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000007831 114.0
TLS2_k127_6666624_29 histidine kinase A domain protein - - - 0.0000000000000000000000003444 124.0
TLS2_k127_6666624_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 518.0
TLS2_k127_6666624_30 nucleic acid phosphodiester bond hydrolysis K07460 - - 0.0000000000000000000001524 111.0
TLS2_k127_6666624_31 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000003685 103.0
TLS2_k127_6666624_32 response regulator K02481 - - 0.00000000002673 78.0
TLS2_k127_6666624_33 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000005537 60.0
TLS2_k127_6666624_34 Domain of unknown function (DUF4136) - - - 0.00001579 58.0
TLS2_k127_6666624_35 HWE histidine kinase - - - 0.0003041 55.0
TLS2_k127_6666624_4 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007658 479.0
TLS2_k127_6666624_5 Belongs to the thiolase family K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 445.0
TLS2_k127_6666624_6 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008858 413.0
TLS2_k127_6666624_7 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004044 404.0
TLS2_k127_6666624_8 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 348.0
TLS2_k127_6666624_9 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004184 327.0
TLS2_k127_667629_0 ABC transporter transmembrane region - - - 2.068e-253 804.0
TLS2_k127_6680368_0 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 500.0
TLS2_k127_6680368_1 Protein of unknown function (DUF1015) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009712 351.0
TLS2_k127_6685625_0 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007641 346.0
TLS2_k127_6685625_1 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000005051 192.0
TLS2_k127_6685625_2 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000004951 167.0
TLS2_k127_6685625_3 Adenylylsulphate kinase K00860 - 2.7.1.25 0.0000000000000000000000003637 115.0
TLS2_k127_6685625_4 Universal stress protein family - - - 0.00000000000000000464 97.0
TLS2_k127_6685625_5 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000005955 82.0
TLS2_k127_6695116_0 Protein of unknown function, DUF547 - - - 0.000000000000000000000000000000000000000000000000000000000000004678 234.0
TLS2_k127_6695116_1 radical SAM domain protein - - - 0.00000000000000000000000000000000000000008989 172.0
TLS2_k127_6695116_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000002554 108.0
TLS2_k127_6695116_3 Lactonase, 7-bladed beta-propeller K07404 - 3.1.1.31 0.0001991 51.0
TLS2_k127_6695392_0 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003621 343.0
TLS2_k127_6695392_1 pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005099 281.0
TLS2_k127_6695392_2 Creatinase/Prolidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001813 263.0
TLS2_k127_6695392_3 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000001983 117.0
TLS2_k127_6700153_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000082 361.0
TLS2_k127_6702778_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008121 395.0
TLS2_k127_6702778_1 Belongs to the SIS family. GutQ KpsF subfamily K01627,K03281,K06041 - 2.5.1.55,5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 373.0
TLS2_k127_6702778_2 lipopolysaccharide transport protein B ATP-binding component of ABC superfamily K01990,K06861 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 291.0
TLS2_k127_6702778_3 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000001078 231.0
TLS2_k127_6702778_4 TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.0000000000000000000000000000000000004534 157.0
TLS2_k127_6702778_5 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.00000000000000000000001424 107.0
TLS2_k127_6702778_6 OstA-like protein K09774 - - 0.000000000000000001014 94.0
TLS2_k127_6702778_7 Lipopolysaccharide-assembly, LptC-related K09774,K11719 - - 0.000009576 56.0
TLS2_k127_6705470_0 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00239,K00244,K00278 GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0022900,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803 1.3.5.1,1.3.5.4,1.4.3.16 1.052e-273 854.0
TLS2_k127_6705470_1 Succinate dehydrogenase fumarate reductase K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007412 379.0
TLS2_k127_6705470_2 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane K00247 - - 0.00000000000000000000000000000006375 127.0
TLS2_k127_6705470_3 - - - - 0.000000000000000000000000005808 115.0
TLS2_k127_6705470_4 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane K00246 - - 0.00000000000000000000000006624 125.0
TLS2_k127_6705470_5 multicopper oxidases - - - 0.0003823 50.0
TLS2_k127_6708809_0 Dehydratase family K01687 - 4.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 405.0
TLS2_k127_6708809_1 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000004272 228.0
TLS2_k127_6715149_0 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 306.0
TLS2_k127_6715149_1 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000002966 224.0
TLS2_k127_6717029_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 4.527e-223 708.0
TLS2_k127_6717029_1 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007424 584.0
TLS2_k127_6717029_2 tRNA synthetase class II core domain (G, H, P, S and T) K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 407.0
TLS2_k127_6717029_3 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 358.0
TLS2_k127_6717029_4 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004514 280.0
TLS2_k127_6717029_5 Involved in DNA repair and RecF pathway recombination K03474,K03584 GO:0008150,GO:0009314,GO:0009628,GO:0050896 2.6.99.2 0.0000000000000000000000000000000000000005864 160.0
TLS2_k127_6717029_6 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000102 94.0
TLS2_k127_6717029_7 - - - - 0.0000007692 60.0
TLS2_k127_6717590_0 ABC transporter substrate-binding protein K02055 - - 0.00000000000000000000000000000000000000000000000000000000000002552 235.0
TLS2_k127_6717590_1 Creatinase/Prolidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000007817 220.0
TLS2_k127_6718482_0 TonB-dependent Receptor Plug K16092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000161 308.0
TLS2_k127_6718482_1 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000002526 248.0
TLS2_k127_6718482_2 Abc transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000002605 227.0
TLS2_k127_6718482_3 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000007299 215.0
TLS2_k127_6718482_4 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.000000000000000000000000000001045 123.0
TLS2_k127_6718482_5 Adenosylcobinamide amidohydrolase - - - 0.0000000000000000000008259 104.0
TLS2_k127_6721482_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 1e-323 1008.0
TLS2_k127_6721482_1 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 349.0
TLS2_k127_6721672_0 Type VI secretion protein K11896 - - 1.541e-229 729.0
TLS2_k127_6721672_1 type VI secretion protein K11895 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 381.0
TLS2_k127_6721672_2 ImpE protein K11898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 291.0
TLS2_k127_6721672_3 Type VI secretion K11897 - - 0.000000000000000000000000000000000000000000001307 169.0
TLS2_k127_6723344_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 582.0
TLS2_k127_6723344_1 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 505.0
TLS2_k127_6723344_2 AMP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000001118 241.0
TLS2_k127_6723344_3 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000004923 231.0
TLS2_k127_6723344_4 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000004356 229.0
TLS2_k127_6723344_5 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000006867 194.0
TLS2_k127_6723344_6 Glycoprotease family K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.0000000000009076 70.0
TLS2_k127_6726333_0 acyl-CoA dehydrogenase K09456,K20035 - - 1.402e-197 643.0
TLS2_k127_6726333_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002096 292.0
TLS2_k127_6726333_2 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000005082 225.0
TLS2_k127_6726333_3 Competence-damaged protein K03742,K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000002033 236.0
TLS2_k127_6726333_4 Polysaccharide deacetylase K11931 - - 0.000000000000000000000000000000000000000000000000000000002368 213.0
TLS2_k127_6726333_5 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 0.0000000000000000000000000003822 122.0
TLS2_k127_6726333_6 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000000116 118.0
TLS2_k127_6726915_0 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008471 312.0
TLS2_k127_6726915_1 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000007967 214.0
TLS2_k127_6726915_2 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000001289 171.0
TLS2_k127_6726915_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00034 - 1.1.1.47 0.00000000000000000000000000000000002979 142.0
TLS2_k127_6730615_0 PFAM dehydrogenase E1 component K21416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 466.0
TLS2_k127_6730615_1 PFAM Transketolase central region K21417 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004568 317.0
TLS2_k127_6734951_0 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 587.0
TLS2_k127_6734951_1 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 314.0
TLS2_k127_6734951_2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000001599 55.0
TLS2_k127_6735451_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 453.0
TLS2_k127_6735451_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005188 290.0
TLS2_k127_6735451_2 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.00000000000000000000000000000000000000000000003337 183.0
TLS2_k127_6735451_3 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000001807 68.0
TLS2_k127_6736151_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 608.0
TLS2_k127_6736151_1 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 346.0
TLS2_k127_6736151_2 fatty acid desaturase - - - 0.0000000000000000000000000000000000000000000000000000000000005452 237.0
TLS2_k127_6736151_3 Luciferase-like monooxygenase - - - 0.0000000000003344 72.0
TLS2_k127_6737381_0 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000000006839 197.0
TLS2_k127_6737381_1 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.000000000000000000000000000000000000000000000003457 181.0
TLS2_k127_6737381_2 Belongs to the ompA family - - - 0.000000000000000000000000000000000005319 140.0
TLS2_k127_6737381_3 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000001736 145.0
TLS2_k127_6738054_0 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 399.0
TLS2_k127_6738054_1 Phosphoglycerate mutase family - - - 0.0000000000000000000000000000000000000000000000000000000000000001688 234.0
TLS2_k127_6738054_2 PFAM Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000001576 227.0
TLS2_k127_6738054_3 NIPSNAP - - - 0.000000000000000000000000000002384 132.0
TLS2_k127_6738054_4 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.000000008232 58.0
TLS2_k127_6741255_0 Belongs to the TPP enzyme family K01576 - 4.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005603 529.0
TLS2_k127_6741255_1 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000001203 225.0
TLS2_k127_6743001_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 373.0
TLS2_k127_6743001_1 Methyl-accepting chemotaxis protein K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000405 301.0
TLS2_k127_6743001_2 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001826 289.0
TLS2_k127_6745371_0 Protein of unknown function (DUF455) K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000002235 207.0
TLS2_k127_6745371_1 Biotin carboxylase K01961,K01965 - 6.3.4.14,6.4.1.2,6.4.1.3 0.000000000000000000007243 93.0
TLS2_k127_6745371_2 Protein of unknown function (DUF455) - - - 0.00000000000000000008124 100.0
TLS2_k127_6747014_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1343.0
TLS2_k127_6747014_1 Molecular chaperone. Has ATPase activity K04079 GO:0000302,GO:0000303,GO:0000305,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0010035,GO:0016020,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071450,GO:0071451,GO:0071944,GO:1901700,GO:1901701 - 9.15e-215 690.0
TLS2_k127_6747014_10 Luciferase-like monooxygenase - - - 0.00000003507 56.0
TLS2_k127_6747014_2 solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 476.0
TLS2_k127_6747014_3 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009097 364.0
TLS2_k127_6747014_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 336.0
TLS2_k127_6747014_5 Binding-protein-dependent transport systems inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 333.0
TLS2_k127_6747014_6 Belongs to the UPF0178 family K09768 - - 0.00000000000000000000000000000000000000000000000000000000000001145 223.0
TLS2_k127_6747014_7 Belongs to the P-Pant transferase superfamily K06133 - - 0.0000000000000000000000000000000000000000000000000000000000000491 226.0
TLS2_k127_6747014_8 Cupin domain - - - 0.000000000004499 72.0
TLS2_k127_6747014_9 DNA-binding transcription factor activity - - - 0.000000000076 69.0
TLS2_k127_6749429_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012,K00066 - 1.1.1.132,1.1.1.22 0.000000000000000000000000000000000000000000000000000000003766 205.0
TLS2_k127_6749429_1 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000001749 189.0
TLS2_k127_6750392_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1790.0
TLS2_k127_6750392_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1475.0
TLS2_k127_6750392_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 1.36e-296 925.0
TLS2_k127_6750392_3 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000294 221.0
TLS2_k127_6750392_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000004375 219.0
TLS2_k127_6750392_5 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000000000009963 156.0
TLS2_k127_6750392_6 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000001196 126.0
TLS2_k127_6750392_7 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000004403 81.0
TLS2_k127_675085_0 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 591.0
TLS2_k127_675085_1 PFAM ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000595 338.0
TLS2_k127_6753202_0 ABC transporter K06022,K06158,K10834 - 3.6.3.29,3.6.3.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 559.0
TLS2_k127_6753202_1 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000005042 233.0
TLS2_k127_6753202_2 SMART HNH nuclease K07451 - - 0.00000000000000000000000000368 127.0
TLS2_k127_6753202_3 Cold shock protein K03704 - - 0.0000000000000000000000002407 110.0
TLS2_k127_6753202_4 pyridoxamine 5'-phosphate K07005 - - 0.0000000000000266 73.0
TLS2_k127_6759451_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 1670.0
TLS2_k127_6759451_1 PFAM CBS domain containing protein K04767 - - 0.00000000001861 68.0
TLS2_k127_6762985_0 alginic acid biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 341.0
TLS2_k127_6764044_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002688 523.0
TLS2_k127_6764044_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003697 415.0
TLS2_k127_6764044_2 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 409.0
TLS2_k127_6764044_3 PFAM Cupin 2 conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000004091 188.0
TLS2_k127_6767409_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 437.0
TLS2_k127_6767409_1 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006813 385.0
TLS2_k127_6767409_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 350.0
TLS2_k127_6767409_3 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 341.0
TLS2_k127_6767409_4 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 353.0
TLS2_k127_6767409_5 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000002967 177.0
TLS2_k127_6767409_6 PilT protein domain protein - - - 0.000000000000000000002005 96.0
TLS2_k127_6767409_7 - - - - 0.000000002131 61.0
TLS2_k127_6769593_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 371.0
TLS2_k127_6769593_1 Cupin 2, conserved barrel domain protein K11312 - - 0.00000000000000000008891 93.0
TLS2_k127_6769593_2 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000001492 58.0
TLS2_k127_6786835_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 521.0
TLS2_k127_6786835_1 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004605 427.0
TLS2_k127_6786835_10 transporter antisigma-factor antagonist STAS K04749 - - 0.0000000000000000002349 91.0
TLS2_k127_6786835_2 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 433.0
TLS2_k127_6786835_3 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005447 418.0
TLS2_k127_6786835_4 Psort location CytoplasmicMembrane, score 10.00 K03458 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 428.0
TLS2_k127_6786835_5 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 329.0
TLS2_k127_6786835_6 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.000000000000000000000000000000000000000000000000000000000276 211.0
TLS2_k127_6786835_7 cheY-homologous receiver domain K11443 - - 0.000000000000000000000000000000000000000002707 178.0
TLS2_k127_6786835_8 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.0000000000000000000000000000002218 124.0
TLS2_k127_6786835_9 Histidine kinase-like ATPase domain - - - 0.00000000000000000000000357 119.0
TLS2_k127_6787702_0 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K05712 - 1.14.13.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007613 433.0
TLS2_k127_6787702_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 392.0
TLS2_k127_6787702_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000002676 230.0
TLS2_k127_6787702_3 Antibiotic biosynthesis monooxygenase K11530 - 5.3.1.32 0.0000000000000000000000000008058 117.0
TLS2_k127_6789662_0 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003392 252.0
TLS2_k127_6789662_1 Lactonase, 7-bladed beta-propeller - - - 0.00000000000000000000000003401 113.0
TLS2_k127_6789662_2 LTXXQ motif family protein - - - 0.0000002148 62.0
TLS2_k127_6789687_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 415.0
TLS2_k127_6789687_1 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 315.0
TLS2_k127_6789687_2 ABC transporter K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008528 268.0
TLS2_k127_6789687_3 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006213 258.0
TLS2_k127_6792938_0 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955 - 2.7.1.25,2.7.7.4 2.322e-201 649.0
TLS2_k127_6792938_1 COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes K00957 - 2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008232 458.0
TLS2_k127_6795007_0 MlrC C-terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003653 434.0
TLS2_k127_6795007_1 ABC transporter substrate-binding protein K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 344.0
TLS2_k127_6795007_2 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 340.0
TLS2_k127_6795007_3 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 310.0
TLS2_k127_6795007_4 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002307 289.0
TLS2_k127_6795007_5 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000001611 231.0
TLS2_k127_6795007_6 2OG-Fe(II) oxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000002221 194.0
TLS2_k127_6795007_7 PFAM NAD dependent epimerase dehydratase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000006229 151.0
TLS2_k127_6795007_8 Thiopurine S-methyltransferase K00569 - 2.1.1.67 0.00000000000000000000000000000000000001111 160.0
TLS2_k127_6795007_9 HAD-hyrolase-like - - - 0.00000000000000000000000000000000000001216 156.0
TLS2_k127_6795012_0 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 478.0
TLS2_k127_6795012_1 Mediates influx of magnesium ions K03284,K16074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000351 438.0
TLS2_k127_6795012_2 Glycosyltransferase family 20 K00697,K13057,K20436 - 2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135 0.00000000000000000000000000000000000000000000000000000000003634 217.0
TLS2_k127_6797532_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007525 593.0
TLS2_k127_6797532_1 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000004606 138.0
TLS2_k127_6799008_0 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 4.966e-246 778.0
TLS2_k127_6799008_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 416.0
TLS2_k127_6799008_2 Hydantoinase B/oxoprolinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002149 300.0
TLS2_k127_6802227_0 Belongs to the peptidase M12A family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009218 394.0
TLS2_k127_6802227_1 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 396.0
TLS2_k127_6802227_2 intermembrane phospholipid transfer K07323 - - 0.0000000000000000000000000000000000000000002788 169.0
TLS2_k127_6802227_3 MgtC family K07507 - - 0.00000000000000000000000000000000000001279 161.0
TLS2_k127_681027_0 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 401.0
TLS2_k127_681027_1 ABC transporter permease K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008635 299.0
TLS2_k127_681027_2 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000008561 159.0
TLS2_k127_681027_3 - - - - 0.00000000001197 68.0
TLS2_k127_681027_4 PFAM Transposase, IS4-like - - - 0.000000211 63.0
TLS2_k127_6812913_0 PFAM binding-protein-dependent transport systems inner membrane component K02053 - - 0.0000000000000000000000000000000000000000000000000000000000000000005379 239.0
TLS2_k127_6812913_1 Creatinase/Prolidase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000001415 189.0
TLS2_k127_6812913_2 Binding-protein-dependent transport system inner membrane component K02054 - - 0.0000000000000000000008686 96.0
TLS2_k127_6814370_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K16871 - 2.6.1.96 1.141e-199 629.0
TLS2_k127_6814370_1 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000006359 96.0
TLS2_k127_6814370_2 Peptidase family M20/M25/M40 K06016 - 3.5.1.6,3.5.1.87 0.00000001131 56.0
TLS2_k127_6821029_1 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000001273 218.0
TLS2_k127_6821029_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000001285 228.0
TLS2_k127_6821029_3 PIN domain K07064 GO:0005575,GO:0005576 - 0.000000000006338 65.0
TLS2_k127_6830508_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 1.88e-219 712.0
TLS2_k127_6830508_1 ABC-type dipeptide transport system periplasmic component K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 340.0
TLS2_k127_6830508_2 ABC-type dipeptide oligopeptide nickel transport K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005882 318.0
TLS2_k127_6830508_3 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002842 279.0
TLS2_k127_6830508_4 Protein of unknown function (DUF917) K09703 - - 0.000000000000000000000000000000000000000000000000000000000000002915 237.0
TLS2_k127_6830508_5 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.0000000000005687 82.0
TLS2_k127_6830508_6 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0008573 46.0
TLS2_k127_6830508_7 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0009906 45.0
TLS2_k127_6835310_0 Sigma-70 region 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 597.0
TLS2_k127_6835310_1 redox protein regulator of disulfide bond formation - - - 0.00000000000000000000000000000000002291 139.0
TLS2_k127_6835310_2 Universal stress protein - - - 0.00000000000000004841 87.0
TLS2_k127_6845083_0 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007835 442.0
TLS2_k127_6845083_1 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes K00627 - 2.3.1.12 0.00000000000000000001332 94.0
TLS2_k127_6845083_2 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit K00161,K11381 - 1.2.4.1,1.2.4.4 0.0000001708 56.0
TLS2_k127_6851480_0 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004601 322.0
TLS2_k127_6851480_1 Ketopantoate reductase PanE/ApbA C terminal - - - 0.000000000000000000000000000000000000000000000000000000002374 210.0
TLS2_k127_6851480_2 Alpha/beta hydrolase family - - - 0.000000000000000000000000000124 119.0
TLS2_k127_6851480_3 addiction module component, TIGR02574 family - - - 0.00001482 52.0
TLS2_k127_6856529_0 Sulfide dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 549.0
TLS2_k127_6856529_1 sulfur oxidation protein (SoxY) K17226 - - 0.00000000000000000000000000000000000000000000000006479 193.0
TLS2_k127_6856529_2 cytochrome c K17223 - - 0.00000000000000000000000000000000000000000000001348 183.0
TLS2_k127_6856529_3 Sulphur oxidation protein SoxZ - - - 0.00000000000000000001937 99.0
TLS2_k127_6857935_0 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 423.0
TLS2_k127_6857935_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002806 283.0
TLS2_k127_6857935_2 ABC transporter substrate-binding protein K02035 - - 0.00000000000000000000000000000000000000000000000000005008 207.0
TLS2_k127_6857935_3 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000001579 201.0
TLS2_k127_6857935_4 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000004387 133.0
TLS2_k127_6857935_5 Putative antitoxin - - - 0.0005938 46.0
TLS2_k127_6862192_0 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006814 267.0
TLS2_k127_6862192_1 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000006482 230.0
TLS2_k127_6862192_2 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000005954 229.0
TLS2_k127_6862192_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000001443 169.0
TLS2_k127_6862192_4 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000006441 129.0
TLS2_k127_6865148_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 389.0
TLS2_k127_6865148_1 Carbon-nitrogen hydrolase K01431 - 3.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000714 257.0
TLS2_k127_6865148_2 NMT1/THI5 like K02051 - - 0.0000000000000000000000000000000000000000000000000000003944 206.0
TLS2_k127_6866378_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 426.0
TLS2_k127_6866378_1 Belongs to the ABC transporter superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002987 368.0
TLS2_k127_6866378_2 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000741 338.0
TLS2_k127_6866378_3 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 291.0
TLS2_k127_6866378_4 PFAM Binding-protein-dependent transport system inner membrane component K02034,K15582 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004022 280.0
TLS2_k127_6866378_5 Glucoamylase and related glycosyl hydrolases - - - 0.000000000000000007168 95.0
TLS2_k127_6866378_6 Sigma-54 interaction domain K15836 - - 0.0000000000000002073 88.0
TLS2_k127_6875541_0 Domain of unknown function (DUF1998) K06877 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 4.14e-255 814.0
TLS2_k127_6875541_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 306.0
TLS2_k127_6875541_2 Exonuclease K07502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005164 262.0
TLS2_k127_6875541_3 ATPases associated with a variety of cellular activities K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000003159 222.0
TLS2_k127_6875541_4 VanZ like family - - - 0.0001602 53.0
TLS2_k127_6875547_0 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000006742 251.0
TLS2_k127_6875547_1 Protein of unknown function (DUF2400) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000338 246.0
TLS2_k127_6875547_2 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000001568 196.0
TLS2_k127_6879198_0 Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 488.0
TLS2_k127_6879198_1 - - - - 0.000952 47.0
TLS2_k127_6887447_0 Hydantoinase/oxoprolinase - - - 0.000000000000000000000000000000000000000000000000000007948 192.0
TLS2_k127_6887447_1 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000001287 172.0
TLS2_k127_6887447_2 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000001781 150.0
TLS2_k127_6887447_3 aminopeptidase activity - - - 0.0001847 45.0
TLS2_k127_6889762_0 CBS domain containing protein - - - 0.00000000000000000000000000000000000001426 153.0
TLS2_k127_6889762_1 - - - - 0.00000000000000000000000000000000001303 140.0
TLS2_k127_6889762_3 Uncharacterized protein conserved in bacteria (DUF2059) K09924 - - 0.0006183 48.0
TLS2_k127_6892391_0 PFAM aldo keto reductase K05882 - 1.1.1.91 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 455.0
TLS2_k127_6892391_1 D-isomer specific 2-hydroxyacid dehydrogenase K00018 - 1.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 428.0
TLS2_k127_6892391_2 Epoxide hydrolase N terminus K01253 - 3.3.2.9 0.000000000000000000000000000000000000000000000000000001048 196.0
TLS2_k127_6892391_3 Endoribonuclease L-PSP - - - 0.000000000000000000000002069 107.0
TLS2_k127_6897861_0 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000001496 119.0
TLS2_k127_6897861_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000005762 74.0
TLS2_k127_6897861_2 cell redox homeostasis - - - 0.000000000001798 71.0
TLS2_k127_6897861_3 PFAM AhpC TSA family - - - 0.000002593 55.0
TLS2_k127_6897861_4 - K21495 - - 0.00006543 49.0
TLS2_k127_6901696_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 1.594e-261 846.0
TLS2_k127_6901696_1 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000005837 259.0
TLS2_k127_6901696_2 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000002757 203.0
TLS2_k127_6906796_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 2.169e-244 792.0
TLS2_k127_6906796_1 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005251 306.0
TLS2_k127_6906796_2 COGs COG4446 conserved - - - 0.000000000000000000000000000000007687 148.0
TLS2_k127_6906796_3 UreD urease accessory protein K03190 - - 0.00000000000000000000000002992 120.0
TLS2_k127_6906796_4 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03188 - - 0.0000000000000002388 85.0
TLS2_k127_6906796_5 Protein of unknown function (DUF3225) - - - 0.00000000000002307 75.0
TLS2_k127_6923186_0 acyl-CoA dehydrogenase K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 484.0
TLS2_k127_6923186_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 422.0
TLS2_k127_6923186_2 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003893 294.0
TLS2_k127_6923186_3 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000002292 250.0
TLS2_k127_69233_0 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000001039 228.0
TLS2_k127_69233_1 phospholipase Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000000000000002067 220.0
TLS2_k127_69233_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000152 92.0
TLS2_k127_6924480_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005334 458.0
TLS2_k127_6924480_1 Glycine-zipper domain - - - 0.000000000000000000000000000000000000000006393 168.0
TLS2_k127_6941195_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009638 526.0
TLS2_k127_6941195_1 pfam abc K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005147 273.0
TLS2_k127_6941195_2 Protein of unknown function (DUF2796) - - - 0.0000000000000000000000000001866 122.0
TLS2_k127_6941195_3 Protein of unknown function (DUF3299) K09950 - - 0.000000000000003707 84.0
TLS2_k127_6947840_0 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 4.573e-197 645.0
TLS2_k127_6947840_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004153 587.0
TLS2_k127_6947840_2 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006146 300.0
TLS2_k127_6947840_3 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007661 306.0
TLS2_k127_6947840_4 Serine aminopeptidase, S33 K19311 GO:0003674,GO:0003824,GO:0005488,GO:0005504,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016298,GO:0016787,GO:0016788,GO:0019752,GO:0031406,GO:0032787,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0072329,GO:0104004,GO:1901575 - 0.0000000000000000000000000000000000001004 163.0
TLS2_k127_6950511_0 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000005377 273.0
TLS2_k127_6950511_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000006644 201.0
TLS2_k127_6964712_0 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000453 139.0
TLS2_k127_6964712_1 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.000000006994 66.0
TLS2_k127_698145_0 Amidohydrolase K07046 - - 0.00000000000000000000000000000000000000000000000000000000000007882 216.0
TLS2_k127_698145_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000004988 224.0
TLS2_k127_698145_2 filamentation induced by cAMP protein Fic - - - 0.00000000000000000000000000000002356 127.0
TLS2_k127_6990182_0 lipopolysaccharide transport K22110 - - 1.085e-207 657.0
TLS2_k127_6996323_0 ABC transporter K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001102 278.0
TLS2_k127_6996323_1 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000003486 194.0
TLS2_k127_6996323_2 PFAM binding-protein-dependent transport systems inner membrane component K15554 - - 0.0000000000000000000000000000000000001963 159.0
TLS2_k127_7019982_0 Cytochrome C and Quinol oxidase polypeptide I K15862 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008346 527.0
TLS2_k127_7019982_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 477.0
TLS2_k127_7019982_2 Putative metal-binding domain of cation transport ATPase K01533 - 3.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 389.0
TLS2_k127_7019982_3 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.000000000000000000000000000000000000000000000008722 180.0
TLS2_k127_7019982_4 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.000000000000000000000000000000000000000000002511 171.0
TLS2_k127_7019982_5 FixH - - - 0.00000000000000000007267 101.0
TLS2_k127_7019982_6 Cbb3-type cytochrome oxidase component FixQ K00407 - - 0.000001005 59.0
TLS2_k127_7033122_0 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003457 306.0
TLS2_k127_7033122_1 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000008089 228.0
TLS2_k127_7033122_2 Esterase of the alpha-beta hydrolase superfamily - - - 0.00000000000000000000000000000000000001376 153.0
TLS2_k127_7033122_3 Amidohydrolase family - - - 0.0005446 45.0
TLS2_k127_7036499_0 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - 2.055e-206 655.0
TLS2_k127_7036499_1 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009815 293.0
TLS2_k127_709787_0 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 405.0
TLS2_k127_709787_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000009855 60.0
TLS2_k127_7102823_0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 285.0
TLS2_k127_7102823_1 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000005796 255.0
TLS2_k127_7104265_0 Glycosyl Transferase - - - 2.173e-233 742.0
TLS2_k127_7104265_1 ROK family - - - 0.000004131 53.0
TLS2_k127_7120868_0 UDP-N-acetylmuramate-alanine ligase K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000001929 249.0
TLS2_k127_7120868_1 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000000006704 192.0
TLS2_k127_7149535_0 PFAM Transposase, IS111A IS1328 IS1533 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001993 248.0
TLS2_k127_7149535_1 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.000000000018 65.0
TLS2_k127_7160058_0 Cytochrome c oxidase, subunit I K04561 - 1.7.2.5 1.359e-219 689.0
TLS2_k127_7160058_1 von Willebrand factor, type A K02448 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 511.0
TLS2_k127_7160058_2 PFAM ATPase associated with various cellular activities K04748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 391.0
TLS2_k127_7160058_3 Cytochrome c K02305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 334.0
TLS2_k127_7160058_4 helix_turn_helix, cAMP Regulatory protein K01420,K21563 - - 0.0000000000000000002254 98.0
TLS2_k127_7179293_0 Taurine catabolism dioxygenase TauD, TfdA family K06912 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007896 404.0
TLS2_k127_7179293_1 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007745 381.0
TLS2_k127_7179293_2 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000008672 193.0
TLS2_k127_7191326_0 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008228 391.0
TLS2_k127_7191326_1 amino acid K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 348.0
TLS2_k127_7191326_2 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 349.0
TLS2_k127_7191326_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000326 96.0
TLS2_k127_7191326_4 ADP-heptose-lipopolysaccharide heptosyltransferase activity - - - 0.00000000000000007555 92.0
TLS2_k127_7205282_0 Caspase domain - - - 0.0 1033.0
TLS2_k127_7205282_1 Cobalamin-independent synthase, Catalytic domain - - - 0.0000000000000000000000006204 105.0
TLS2_k127_7234680_0 DnaJ central domain K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 405.0
TLS2_k127_7234680_1 HrcA protein C terminal domain K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000008804 246.0
TLS2_k127_7234680_2 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000001826 179.0
TLS2_k127_7234680_3 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000000000000000003574 154.0
TLS2_k127_7234680_4 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000001403 137.0
TLS2_k127_7268045_0 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000003549 242.0
TLS2_k127_7268045_1 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000005315 233.0
TLS2_k127_7268045_2 PFAM FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.00000000000000000000000000000000000000000000003725 171.0
TLS2_k127_7334385_0 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006044 316.0
TLS2_k127_7334385_1 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 294.0
TLS2_k127_7334385_2 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000003335 64.0
TLS2_k127_7335057_0 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000003512 190.0
TLS2_k127_7335057_1 Cupin - - - 0.0000000000000000000000000000000000000000000003401 174.0
TLS2_k127_7335057_2 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000004925 139.0
TLS2_k127_7335057_3 carbon monoxide dehydrogenase K03518 - 1.2.5.3 0.00000000000000000000003887 100.0
TLS2_k127_7335057_4 PFAM thioesterase superfamily K02614 - - 0.00000000000000000001958 94.0
TLS2_k127_7335057_5 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.00000009015 61.0
TLS2_k127_7335057_6 Nitroreductase family - - - 0.000005121 49.0
TLS2_k127_736569_0 copper-translocating P-type ATPase K17686 - 3.6.3.54 2.295e-249 780.0
TLS2_k127_7433696_0 Flavoprotein involved in K transport K03379,K21730 - 1.14.13.160,1.14.13.22 5.226e-282 877.0
TLS2_k127_7433696_1 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family K21833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008797 419.0
TLS2_k127_7433696_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000002195 139.0
TLS2_k127_78512_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 290.0
TLS2_k127_78512_1 Type I site-specific restriction-modification system, R (Restriction) subunit and related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000144 273.0
TLS2_k127_78512_2 COG0044 Dihydroorotase and related cyclic amidohydrolases K01464,K01465 - 3.5.2.2,3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000005833 232.0
TLS2_k127_78512_3 amino acid-binding ACT domain protein K04518 - 4.2.1.51 0.0000000000000000000000002686 109.0
TLS2_k127_78512_4 type I site-specific deoxyribonuclease activity K01153 - 3.1.21.3 0.000000000000000007451 85.0
TLS2_k127_78512_5 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.0008097 47.0
TLS2_k127_802425_0 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001521 256.0
TLS2_k127_802425_1 - - - - 0.00000000000000000000000008406 108.0
TLS2_k127_802425_2 - - - - 0.0000000000000000006893 89.0
TLS2_k127_823480_0 Uncharacterised nucleotidyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 347.0
TLS2_k127_823480_1 HPr kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 328.0
TLS2_k127_823480_2 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000004497 218.0
TLS2_k127_823480_3 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000001195 148.0
TLS2_k127_823480_4 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.0000000000000000000000000000004163 134.0
TLS2_k127_823480_5 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.000000000000000000000000000002328 132.0
TLS2_k127_823480_6 - - - - 0.00000001359 60.0
TLS2_k127_83067_0 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002367 235.0
TLS2_k127_83067_1 EamA-like transporter family - - - 0.0000000000000000000000000000004017 136.0
TLS2_k127_8592_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0 3173.0
TLS2_k127_8592_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 1.877e-245 767.0
TLS2_k127_8592_2 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.00000000000000000000000000000000000000000000000001395 185.0
TLS2_k127_8592_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000000000002887 178.0
TLS2_k127_8592_4 Na -driven multidrug efflux pump K03327 - - 0.00000000000000000000000000000000000000000006754 163.0
TLS2_k127_87867_0 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 460.0
TLS2_k127_87867_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002242 272.0
TLS2_k127_88955_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 7.328e-233 733.0
TLS2_k127_88955_1 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 469.0
TLS2_k127_88955_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008421 411.0
TLS2_k127_88955_3 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033,K15581 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 325.0
TLS2_k127_88955_4 ABC transporter permease K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001072 282.0
TLS2_k127_88955_5 family 5 K02035 - - 0.000000000000000000000000000000000000000000000000000006589 201.0
TLS2_k127_88955_6 SnoaL-like domain - - - 0.000000000000000000000000000000001398 137.0
TLS2_k127_92611_0 PhoQ Sensor - - - 0.000004542 59.0
TLS2_k127_93138_0 Histidine kinase - - - 0.00000000000000000000000000000000000000005003 171.0
TLS2_k127_93354_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000009828 222.0
TLS2_k127_93354_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000001021 183.0
TLS2_k127_93354_2 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.0000000000000000000000000002217 119.0
TLS2_k127_93449_0 Oxidoreductase FAD-binding domain K15765 - 1.18.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 362.0
TLS2_k127_93449_1 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005818 254.0
TLS2_k127_93449_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000507 220.0
TLS2_k127_93449_3 PFAM amidohydrolase 2 - - - 0.00000000000000000000000000000000002705 138.0
TLS2_k127_93449_4 Ferredoxin - - - 0.00000000000000002025 96.0
TLS2_k127_93449_5 Rieske [2Fe-2S] domain K15762 - - 0.000000000000001017 91.0
TLS2_k127_93449_6 transmembrane signaling receptor activity K03406 - - 0.000000000001493 77.0
TLS2_k127_935476_0 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004134 271.0
TLS2_k127_935476_1 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005518 261.0
TLS2_k127_935476_2 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000004026 145.0
TLS2_k127_935476_3 synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000001904 65.0
TLS2_k127_936492_0 Sugar (and other) transporter K03446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 386.0
TLS2_k127_937671_0 FAD dependent oxidoreductase K00285 - 1.4.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 445.0
TLS2_k127_937671_1 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 372.0
TLS2_k127_937671_2 Proline racemase K01777 - 5.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000001092 253.0
TLS2_k127_937671_3 C4-dicarboxylate transporter, substrate-binding protein - - - 0.00000000000003115 76.0
TLS2_k127_939145_0 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 397.0
TLS2_k127_939145_1 zinc ion binding K07048 GO:0008150,GO:0009888,GO:0009987,GO:0030154,GO:0030855,GO:0032502,GO:0048856,GO:0048869,GO:0060429 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002126 284.0
TLS2_k127_939145_2 Allophanate hydrolase subunit 2 K06350 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008657 293.0
TLS2_k127_939145_3 Allophanate hydrolase subunit 1 K06351 - - 0.00000000000000000000000000000000000000000000000000000000000000005152 234.0
TLS2_k127_939145_4 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000005638 205.0
TLS2_k127_939806_0 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002535 429.0
TLS2_k127_939806_1 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 430.0
TLS2_k127_939806_2 Methionine biosynthesis protein MetW K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 318.0
TLS2_k127_939806_3 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes K00627 - 2.3.1.12 0.0000000000000000001182 94.0
TLS2_k127_941676_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003173 381.0
TLS2_k127_941676_1 RNA-metabolising metallo-beta-lactamase K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 336.0
TLS2_k127_941676_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000003814 240.0
TLS2_k127_941676_3 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752,K13818 - 2.7.7.77 0.000000000001206 71.0
TLS2_k127_947158_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 9.756e-210 664.0
TLS2_k127_94761_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1119.0
TLS2_k127_94761_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006007 365.0
TLS2_k127_94761_2 - - - - 0.0000000000000000000000000000000000000000000002126 175.0
TLS2_k127_94761_3 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000009122 147.0
TLS2_k127_94761_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000001133 145.0
TLS2_k127_94761_5 Bacterial transcriptional repressor C-terminal K16137 - - 0.00000000000000000000000000002846 128.0
TLS2_k127_94761_6 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059,K21883 - 1.1.1.100,1.1.1.401 0.00000009365 57.0
TLS2_k127_94761_7 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.0000008214 53.0
TLS2_k127_952800_0 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 293.0
TLS2_k127_952800_1 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001577 287.0
TLS2_k127_952800_2 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005535 282.0
TLS2_k127_952800_3 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004156 276.0
TLS2_k127_952800_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000002351 220.0
TLS2_k127_952800_5 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.0000000000005343 73.0
TLS2_k127_953773_0 Belongs to the citrate synthase family K01647,K01659 - 2.3.3.1,2.3.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009094 311.0
TLS2_k127_953773_1 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 0.000000000000000000000000000000000003242 140.0
TLS2_k127_956370_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 2.195e-265 855.0
TLS2_k127_956370_1 Bacterial extracellular solute-binding protein K05813 - - 2.242e-198 631.0
TLS2_k127_956370_10 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000000664 236.0
TLS2_k127_956370_11 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000000000000000001776 215.0
TLS2_k127_956370_12 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000001005 179.0
TLS2_k127_956370_13 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000001109 73.0
TLS2_k127_956370_14 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.00002397 49.0
TLS2_k127_956370_2 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 616.0
TLS2_k127_956370_3 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 595.0
TLS2_k127_956370_4 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 582.0
TLS2_k127_956370_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003655 472.0
TLS2_k127_956370_6 Binding-protein-dependent transport system inner membrane component K05814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 444.0
TLS2_k127_956370_7 probably responsible for the translocation of the substrate across the membrane K05815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009547 396.0
TLS2_k127_956370_8 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 368.0
TLS2_k127_956370_9 COGs COG0647 sugar phosphatase of the HAD superfamily K01101,K02566 - 3.1.3.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002266 281.0
TLS2_k127_957042_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 3.389e-308 987.0
TLS2_k127_957042_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000001142 213.0
TLS2_k127_957042_2 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000006351 92.0
TLS2_k127_961916_0 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 393.0
TLS2_k127_961916_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 294.0
TLS2_k127_962436_0 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004471 593.0
TLS2_k127_962436_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000446 540.0
TLS2_k127_962436_2 PFAM alanine racemase domain protein K20757 - 4.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000008247 265.0
TLS2_k127_962436_3 TRAP-type mannitol chloroaromatic compound transport system small permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001898 248.0
TLS2_k127_965983_0 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000049 246.0
TLS2_k127_965983_1 Transcriptional regulator sugar kinase K00886 - 2.7.1.63 0.00000000000000000000000000000003224 129.0
TLS2_k127_966990_0 ABC transporter substrate-binding protein K02055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008506 387.0
TLS2_k127_966990_1 import. Responsible for energy coupling to the transport system K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005136 290.0
TLS2_k127_966990_2 xaa-pro aminopeptidase K01271 - 3.4.13.9 0.000000000000000000000001081 108.0
TLS2_k127_969255_0 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009487 397.0
TLS2_k127_969255_1 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 351.0
TLS2_k127_969255_2 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006543 260.0
TLS2_k127_969255_3 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000006616 238.0
TLS2_k127_969255_4 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000007939 227.0
TLS2_k127_969255_5 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000005926 129.0
TLS2_k127_969255_6 -acetyltransferase - - - 0.0000000000000000000000000002077 122.0
TLS2_k127_969255_7 BrnA antitoxin of type II toxin-antitoxin system - - - 0.00001476 48.0
TLS2_k127_9693_0 type VI secretion protein K11891 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 324.0
TLS2_k127_9693_1 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001123 274.0
TLS2_k127_9693_2 Forkhead associated domain K07169 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005406 253.0
TLS2_k127_9693_3 Uncharacterized protein conserved in bacteria (DUF2094) K11890 - - 0.000000000000000000000000000000000000000216 163.0
TLS2_k127_971954_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 1.136e-300 940.0
TLS2_k127_971954_1 Aldo/keto reductase family K05275 - 1.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007835 460.0
TLS2_k127_971954_2 Cyclase dehydrase - - - 0.000000000000000002258 90.0
TLS2_k127_974827_0 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 333.0
TLS2_k127_974827_1 Lipocalin-like domain - - - 0.0000000546 55.0
TLS2_k127_974827_2 Iron permease FTR1 K07243 - - 0.00000839 48.0
TLS2_k127_974827_3 Luciferase-like monooxygenase - - - 0.00001864 51.0
TLS2_k127_977976_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K16877 - 1.3.99.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 582.0
TLS2_k127_977976_1 Rieske (2Fe-2S) domain-containing protein K15060 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005481 518.0
TLS2_k127_977976_2 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000001177 238.0
TLS2_k127_977976_3 2Fe-2S -binding domain protein K03518,K07302,K19819 - 1.2.5.3,1.3.99.16,1.5.99.4 0.00000000000000000000000000000000000000000000000002303 196.0
TLS2_k127_977976_4 amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000009289 164.0
TLS2_k127_982565_0 Acyl-CoA dehydrogenase, N-terminal domain K00248,K00249,K18244 - 1.3.8.1,1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 562.0
TLS2_k127_982565_1 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000006991 115.0
TLS2_k127_982565_2 - - - - 0.0000000000000000003095 95.0
TLS2_k127_983884_0 Late control gene D protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 476.0
TLS2_k127_983884_1 LysM domain - - - 0.00000000000000000000000000000000000000000008038 164.0
TLS2_k127_983884_2 Baseplate assembly protein - - - 0.0000000000000000000000000000000000000000004279 177.0
TLS2_k127_983884_3 - - - - 0.00000000000000000000000000000001136 130.0
TLS2_k127_983884_4 GPW gp25 family protein K06903 - - 0.000000000000003407 78.0
TLS2_k127_983884_5 - - - - 0.00003331 46.0
TLS2_k127_987561_0 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 372.0
TLS2_k127_987561_1 Malate/L-lactate dehydrogenase - - - 0.0000000000000000000000000000000000000117 153.0
TLS2_k127_999191_0 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K15060 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 542.0
TLS2_k127_999191_1 Glycosyltransferase family 28 C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002306 235.0
TLS2_k127_999191_2 Membrane protein involved in the export of O-antigen and teichoic acid K03328 - - 0.000000000000000000000000000000000000000003296 173.0