Overview

ID MAG04009
Name TLS2_bin.48
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Rhizobiales
Family Methyloligellaceae
Genus Methyloceanibacter
Species
Assembly information
Completeness (%) 63.05
Contamination (%) 1.67
GC content (%) 64.0
N50 (bp) 4,164
Genome size (bp) 1,612,674

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1802

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_100125_0 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000974 342.0
TLS2_k127_100125_1 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006218 309.0
TLS2_k127_100125_2 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001307 269.0
TLS2_k127_100125_3 von Willebrand factor, type A - - - 0.000000000000000000000000000000000000000000000000000002879 199.0
TLS2_k127_100125_4 (twin-arginine translocation) pathway signal - - - 0.00000000000000000000000000001019 133.0
TLS2_k127_100157_0 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 447.0
TLS2_k127_100157_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 333.0
TLS2_k127_100157_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000005333 117.0
TLS2_k127_100157_3 Domain of unknown function (DUF1476) - - - 0.0000000000003615 72.0
TLS2_k127_1006922_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 1.241e-237 747.0
TLS2_k127_1006922_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052,K11072,K11076 - 3.6.3.31 2.511e-197 634.0
TLS2_k127_1006922_2 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 503.0
TLS2_k127_1006922_3 Binding-protein-dependent transport system inner membrane component K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 431.0
TLS2_k127_1006922_4 putrescine K11071 - - 0.0000000000000000000000000000000000000000000000000000000004147 202.0
TLS2_k127_1007686_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 1.067e-211 667.0
TLS2_k127_1007686_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005395 549.0
TLS2_k127_1007686_2 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 356.0
TLS2_k127_1007686_3 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000005866 239.0
TLS2_k127_1007686_4 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000008734 225.0
TLS2_k127_101377_0 Catalyzes the NAD( )-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non- methylotrophic organisms K00122 - 1.17.1.9 1.674e-222 698.0
TLS2_k127_101377_1 PFAM regulatory protein LysR - - - 0.000000000000000000000000001711 115.0
TLS2_k127_101377_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000001318 91.0
TLS2_k127_1015040_0 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 456.0
TLS2_k127_1015040_1 ATPases associated with a variety of cellular activities K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004878 379.0
TLS2_k127_1015040_2 ABC-type transport auxiliary lipoprotein component K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006499 336.0
TLS2_k127_1017085_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005702 327.0
TLS2_k127_1017085_1 Divergent polysaccharide deacetylase K09798 - - 0.000000000000000000000000000000000000000000000000000000000000004043 226.0
TLS2_k127_1017085_2 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.0000000000000000000000000000000000000000000000000000000000002131 217.0
TLS2_k127_1017085_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02113,K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000002972 149.0
TLS2_k127_1026479_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1302.0
TLS2_k127_1026479_1 PRC-barrel domain - - - 0.0000000000000000008024 97.0
TLS2_k127_1026479_2 PFAM Acyltransferase - - - 0.0002096 46.0
TLS2_k127_1039920_0 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 5.828e-200 628.0
TLS2_k127_1039920_1 His Kinase A (phospho-acceptor) domain K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 513.0
TLS2_k127_1039920_2 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000003178 93.0
TLS2_k127_1045750_0 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 390.0
TLS2_k127_1045750_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 340.0
TLS2_k127_1045750_2 S-adenosylmethionine decarboxylase K00797,K01611 - 2.5.1.16,4.1.1.50 0.00000000000000000000000000000000000000000000000000000000000000000000000136 248.0
TLS2_k127_1045750_3 Phosphodiester glycosidase - - - 0.000000000000000000000000000000000000000001325 159.0
TLS2_k127_1058868_0 PAS fold K07716 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006338 621.0
TLS2_k127_1058868_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 555.0
TLS2_k127_1058868_2 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004907 425.0
TLS2_k127_1091788_0 Belongs to the DEAD box helicase family K03732,K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 493.0
TLS2_k127_1091788_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 373.0
TLS2_k127_1091788_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000005946 119.0
TLS2_k127_1102012_0 chorismate binding enzyme K01665,K03342 - 2.6.1.85,4.1.3.38 4.797e-196 631.0
TLS2_k127_1102012_1 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004446 354.0
TLS2_k127_1102012_2 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000001651 228.0
TLS2_k127_1102012_3 TIGRFAM formylmethanofuran dehydrogenase subunit C K00202 - 1.2.7.12 0.000000000000000000000000000000000000000001623 162.0
TLS2_k127_1102012_4 Protein of unknown function (DUF3309) - - - 0.0000000000000000002814 88.0
TLS2_k127_1102012_5 - - - - 0.00000003504 59.0
TLS2_k127_1102012_6 CsbD-like - - - 0.0000002077 52.0
TLS2_k127_1110182_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 571.0
TLS2_k127_1110182_1 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 469.0
TLS2_k127_1110182_2 Putative methyltransferase K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000002959 219.0
TLS2_k127_1110182_3 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000001242 212.0
TLS2_k127_1110182_4 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000001796 166.0
TLS2_k127_1110182_5 Transcriptional regulator - - - 0.000000000000000000000000000000000000000004011 160.0
TLS2_k127_1110182_6 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000009527 123.0
TLS2_k127_1116949_0 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 8.902e-308 956.0
TLS2_k127_1116949_1 reductase K00001,K14446 - 1.1.1.1,1.3.1.85 4.95e-243 754.0
TLS2_k127_1119661_0 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 1.571e-285 895.0
TLS2_k127_1119661_1 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 355.0
TLS2_k127_113262_0 GTP-binding protein TypA K06207 GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004876 525.0
TLS2_k127_113262_1 Tetratricopeptide repeats - - - 0.00001773 54.0
TLS2_k127_1133767_0 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001438 276.0
TLS2_k127_1133767_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000001823 96.0
TLS2_k127_1136290_0 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 626.0
TLS2_k127_1136290_1 Bacterial protein of unknown function (DUF853) K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008427 490.0
TLS2_k127_1136290_2 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000005156 261.0
TLS2_k127_1144870_0 DEAD/H associated K03724 - - 0.0 1902.0
TLS2_k127_1144870_1 FMN binding - - - 0.000000000000000000000000000000000000000000000000000000002576 208.0
TLS2_k127_1144870_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000002257 67.0
TLS2_k127_1158567_0 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004863 289.0
TLS2_k127_1158567_1 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000364 207.0
TLS2_k127_1158567_2 NADH ubiquinone oxidoreductase subunit NDUFA12 K00356 - 1.6.99.3 0.00000000000000000000000000000000000000000001526 169.0
TLS2_k127_1158567_3 cheY-homologous receiver domain K03413 - - 0.000000000000000000000006197 108.0
TLS2_k127_1172812_0 protein histidine kinase activity K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000006972 145.0
TLS2_k127_1172812_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 0.000000000000000000000198 100.0
TLS2_k127_1178658_0 d-alanyl-d-alanine carboxypeptidase K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005238 570.0
TLS2_k127_1178658_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 374.0
TLS2_k127_1178658_2 glutamine amidotransferase K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 301.0
TLS2_k127_1178658_3 PFAM peptidase, membrane zinc metallopeptidase K06973 - - 0.0000000000000000000000000000000000000000000000000000000000000007729 227.0
TLS2_k127_1178658_4 Putative neutral zinc metallopeptidase K06973 - - 0.000002321 50.0
TLS2_k127_1197774_0 Histidine kinase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005858 598.0
TLS2_k127_1197774_1 Threonylcarbamoyl adenosine biosynthesis protein TsaE K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 520.0
TLS2_k127_1197774_2 Nucleotidyl transferase K00966,K00992 - 2.7.7.13,2.7.7.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 297.0
TLS2_k127_1197774_3 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000002897 265.0
TLS2_k127_1197774_4 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000111 154.0
TLS2_k127_1200161_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 320.0
TLS2_k127_1200161_1 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000001829 214.0
TLS2_k127_1200161_2 cyclic nucleotide-binding K03321 - - 0.000000000000000000000000000001194 133.0
TLS2_k127_1200161_3 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000002447 121.0
TLS2_k127_1200161_4 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.00000000000000000000000002789 114.0
TLS2_k127_1200161_5 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.000000000000000000000001245 107.0
TLS2_k127_1200161_6 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.0000000000000000006868 93.0
TLS2_k127_1200161_7 CutA1 divalent ion tolerance protein K03926 - - 0.00000001262 56.0
TLS2_k127_1202544_0 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 518.0
TLS2_k127_1202544_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 512.0
TLS2_k127_1202544_2 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004358 405.0
TLS2_k127_121138_0 Protein of unknown function (DUF3570) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000425 325.0
TLS2_k127_121138_1 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009387 263.0
TLS2_k127_121138_2 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000369 239.0
TLS2_k127_121138_3 Cytochrome P460 - - - 0.00000000000000000000000000000000000000000001796 166.0
TLS2_k127_1223174_0 HlyD family secretion protein K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007132 353.0
TLS2_k127_1223174_1 alcohol dehydrogenase K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000002866 246.0
TLS2_k127_1256693_0 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001949 286.0
TLS2_k127_1256693_1 NusB family K03625 - - 0.00000000000000000000000000000000000000000000000000001804 194.0
TLS2_k127_1256693_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000003099 110.0
TLS2_k127_1270639_0 Predicted membrane protein (DUF2254) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 362.0
TLS2_k127_1270639_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000408 215.0
TLS2_k127_1270639_2 Helix-turn-helix K21498 - - 0.0000000000000000000000000000000000000006704 151.0
TLS2_k127_1270639_3 Plasmid maintenance system killer - - - 0.000000000000000000000000005092 111.0
TLS2_k127_1274356_0 Carboxyl transferase domain K01966 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0031974,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0070013,GO:0071704,GO:0072329,GO:1901575 2.1.3.15,6.4.1.3 4.135e-247 766.0
TLS2_k127_1274356_1 RNA pseudouridylate synthase K06179 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 444.0
TLS2_k127_1274356_2 ATP12 chaperone protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004798 263.0
TLS2_k127_1274356_3 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.00000000000000000000000000000000000000000000000002662 182.0
TLS2_k127_1274356_4 Low affinity iron permease - - - 0.00000000000000000000000000000000000000000003427 164.0
TLS2_k127_1274356_5 Kazal type serine protease inhibitors - - - 0.0000000000000000000003987 100.0
TLS2_k127_1274356_6 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000005508 91.0
TLS2_k127_1274356_7 Uncharacterized ACR, COG1993 K09137 - - 0.00000002463 58.0
TLS2_k127_1278627_0 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 301.0
TLS2_k127_1278627_1 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000002205 208.0
TLS2_k127_1278627_2 transferase activity, transferring glycosyl groups - - - 0.000002178 49.0
TLS2_k127_1284718_0 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 328.0
TLS2_k127_1284718_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 322.0
TLS2_k127_1284718_2 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000873 290.0
TLS2_k127_1284718_3 PFAM Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000009334 188.0
TLS2_k127_1288219_0 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 1.346e-207 655.0
TLS2_k127_1288219_1 Bacterial protein of unknown function (DUF924) - - - 0.00000000000000000000000000000000000000000000000000000003704 204.0
TLS2_k127_1288219_2 Thioredoxin-like - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000005675 187.0
TLS2_k127_1288219_3 YARHG - - - 0.00000000000000000006145 100.0
TLS2_k127_1320753_0 Allophanate hydrolase subunit 2 K01941 - 6.3.4.6 0.0 1125.0
TLS2_k127_1320753_1 Allophanate hydrolase subunit 2 K01941 - 6.3.4.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 441.0
TLS2_k127_1320753_2 Domain of unknown function (DUF1989) K09967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 405.0
TLS2_k127_1320753_3 Amidase K01457 - 3.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009951 406.0
TLS2_k127_1320753_4 Domain of unknown function (DUF1989) K09967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 376.0
TLS2_k127_1320753_5 Amidase K01457 - 3.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 357.0
TLS2_k127_1320753_6 glutamine synthetase K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003116 300.0
TLS2_k127_1320753_7 Allophanate hydrolase subunit 2 K01941 - 6.3.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004842 295.0
TLS2_k127_1320753_8 NikR C terminal nickel binding domain K07722 - - 0.000000000000000000000000000000000000000000000000000004046 194.0
TLS2_k127_1320753_9 Patatin-like phospholipase - - - 0.0000000000000000000000007017 106.0
TLS2_k127_1370679_0 Major Facilitator Superfamily - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002858 582.0
TLS2_k127_1370679_1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 467.0
TLS2_k127_1370679_2 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 431.0
TLS2_k127_1370679_3 FtsJ-like methyltransferase K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000125 284.0
TLS2_k127_1379118_0 TIGRFAM phage - - - 0.000000000000000000000000000000000000000000000000000000000000002083 224.0
TLS2_k127_1379118_1 DNA methylase - - - 0.0000000000000000000000000000000000006916 143.0
TLS2_k127_1379118_2 Histidine kinase - - - 0.00000000000000000000000001501 119.0
TLS2_k127_1379118_3 - - - - 0.000000000000000009399 90.0
TLS2_k127_1379118_4 Terminase RNaseH-like domain - - - 0.00000000000000047 85.0
TLS2_k127_1379118_5 Bacterial sugar transferase - - - 0.00000001594 59.0
TLS2_k127_1397106_0 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 374.0
TLS2_k127_1397106_1 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000006422 186.0
TLS2_k127_1397106_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.0000000000408 63.0
TLS2_k127_1406201_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 567.0
TLS2_k127_1406201_1 Heat shock 70 kDa protein K04043 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 310.0
TLS2_k127_141618_0 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 498.0
TLS2_k127_141618_1 PFAM secretion protein HlyD family protein K03543,K15549 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001164 272.0
TLS2_k127_141618_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.000000000000000000000000000000000000000000000000000000000000000000002764 246.0
TLS2_k127_1445157_0 Patatin-like phospholipase K07001 GO:0003674,GO:0003824,GO:0016787 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 379.0
TLS2_k127_1445157_1 GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 289.0
TLS2_k127_1445157_2 COG0822 NifU homolog involved in Fe-S cluster formation - - - 0.0000000000000000000000000000000000000000000000000000001797 198.0
TLS2_k127_1445157_3 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000000000001091 196.0
TLS2_k127_1445157_4 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000003035 191.0
TLS2_k127_1445157_5 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000004864 153.0
TLS2_k127_1445157_6 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000000000000002078 141.0
TLS2_k127_1445157_7 Putative restriction endonuclease - - - 0.00004633 46.0
TLS2_k127_144919_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 347.0
TLS2_k127_144919_1 PFAM Diacylglycerol kinase catalytic - - - 0.00000000000000000000000000000000000000000000000000002737 199.0
TLS2_k127_144919_2 Histidine kinase - - - 0.0000000000000000000000000003263 119.0
TLS2_k127_144919_3 CsbD-like - - - 0.000000000000000000000000001947 113.0
TLS2_k127_144919_4 SelR domain K07305 - 1.8.4.12 0.000000000000002593 79.0
TLS2_k127_144919_5 UPF0391 membrane protein - - - 0.00000000002306 65.0
TLS2_k127_145464_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.0 1159.0
TLS2_k127_145464_1 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 469.0
TLS2_k127_145464_2 - - - - 0.00000000000000000000000000000000002565 137.0
TLS2_k127_1459246_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 437.0
TLS2_k127_1459246_2 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009035 278.0
TLS2_k127_1459246_3 Protein of unknown function (DUF3108) - - - 0.00000000000146 76.0
TLS2_k127_146992_0 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 353.0
TLS2_k127_146992_1 MotA/TolQ/ExbB proton channel family K03562 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 293.0
TLS2_k127_146992_2 Cell division and transport-associated protein TolA K03646 - - 0.00000000000000000000000000000000000000008518 162.0
TLS2_k127_146992_3 Biopolymer transport protein K03559,K03560 - - 0.0000000000000000000000000000000001084 139.0
TLS2_k127_1484259_0 Tellurite resistance protein TerB K05801 - - 0.0000000000000000000000000000000000000000000000000000000000000000006108 241.0
TLS2_k127_1484259_1 Permease family K06901 - - 0.0000000000000000000000000000000000000000000000000000002239 198.0
TLS2_k127_1497134_0 NADH-quinone oxidoreductase chain K00342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 3.552e-238 746.0
TLS2_k127_1497134_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 288.0
TLS2_k127_1497134_2 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000004117 205.0
TLS2_k127_1501921_0 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006463 379.0
TLS2_k127_1501921_1 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000006342 233.0
TLS2_k127_1501921_2 integral membrane protein - - - 0.0000000000000000000000000000000001276 140.0
TLS2_k127_151131_0 PFAM acyl-CoA dehydrogenase K11731,K14448 - 1.3.8.12 3.336e-255 797.0
TLS2_k127_151131_1 Electron transfer flavoprotein K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 383.0
TLS2_k127_151131_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - GO:0003674,GO:0003824,GO:0004033,GO:0008106,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 327.0
TLS2_k127_151131_3 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006917 271.0
TLS2_k127_151131_4 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001349 274.0
TLS2_k127_151131_5 Electron transfer flavoprotein K03522 - - 0.000000000000000000000000000000000000000000001335 168.0
TLS2_k127_151131_6 PFAM TspO MBR family K05770 - - 0.000000000000000000000000000000000000003053 151.0
TLS2_k127_151131_7 Hypoxia induced protein conserved region - - - 0.00000000000006003 83.0
TLS2_k127_1538119_0 Transposase DDE domain group 1 - - - 4.799e-223 698.0
TLS2_k127_1538119_1 Adenylosuccinate synthetase K01939 - 6.3.4.4 0.000004772 53.0
TLS2_k127_1540090_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003693 484.0
TLS2_k127_1540090_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 494.0
TLS2_k127_1540090_2 PhoH-like protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008787 397.0
TLS2_k127_1540090_3 Transporter associated domain K06189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 323.0
TLS2_k127_1540090_4 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000001096 195.0
TLS2_k127_1540090_5 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000001171 147.0
TLS2_k127_1540090_6 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000001653 89.0
TLS2_k127_154297_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.1.2.1 9.348e-222 693.0
TLS2_k127_154297_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858,K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 499.0
TLS2_k127_154297_2 RibD C-terminal domain K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004741 338.0
TLS2_k127_154297_3 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006675 254.0
TLS2_k127_154297_4 riboflavin synthase, alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000002295 230.0
TLS2_k127_154297_5 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000001727 156.0
TLS2_k127_154297_6 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000001903 99.0
TLS2_k127_154297_7 Sulfite exporter TauE/SafE K07090 - - 0.0000000002169 68.0
TLS2_k127_1556597_0 PFAM Aminotransferase class IV K00824 - 2.6.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004462 270.0
TLS2_k127_1556597_1 Domain of unknown function (DUF892) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001702 238.0
TLS2_k127_1556597_2 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000007736 239.0
TLS2_k127_1556597_3 - - - - 0.000003042 59.0
TLS2_k127_15854_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 420.0
TLS2_k127_15854_1 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000000000000006076 238.0
TLS2_k127_1754758_0 TrkA-N domain - - - 4.879e-214 678.0
TLS2_k127_1754758_1 glycoside hydrolase family 25 K07273 - - 0.000000000000000000000000000000000000006103 150.0
TLS2_k127_1754758_2 Protein of unknown function (DUF2852) - - - 0.00000000000000000000000000000000000004215 148.0
TLS2_k127_1766424_0 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000002417 258.0
TLS2_k127_1766424_1 protein containing LysM domain - - - 0.000000000000000000000000000000000566 146.0
TLS2_k127_1766424_2 protein containing LysM domain - - - 0.000000149 59.0
TLS2_k127_1779890_0 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000004155 241.0
TLS2_k127_1779890_1 long-chain fatty acid transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000021 219.0
TLS2_k127_1779890_2 - - - - 0.0000000000000000000000003454 106.0
TLS2_k127_1779890_3 - - - - 0.00000002364 56.0
TLS2_k127_179424_0 Universal stress protein family - - - 0.000000000000000000000000000000000000000000000000000000118 199.0
TLS2_k127_179424_1 lipopolysaccharide transport K09774 - - 0.000000000000000000000000000000000000000000001676 175.0
TLS2_k127_1843459_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000007263 187.0
TLS2_k127_1843459_1 Phasin protein - - - 0.000004126 54.0
TLS2_k127_186676_0 glutamine synthetase K01915 - 6.3.1.2 5.574e-195 614.0
TLS2_k127_186676_1 Belongs to the aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006822 285.0
TLS2_k127_1878498_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 4.997e-285 885.0
TLS2_k127_1878498_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 3.905e-226 704.0
TLS2_k127_1878498_2 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 344.0
TLS2_k127_1878498_3 signal peptide peptidase SppA, 36K type K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 310.0
TLS2_k127_1878498_4 Cytidylate kinase K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000002208 226.0
TLS2_k127_1878498_5 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000002641 228.0
TLS2_k127_1878498_6 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.000000000000000000000000000000000000000000005972 164.0
TLS2_k127_1878498_7 Pfam:DUF1049 - - - 0.00000000000000000002575 94.0
TLS2_k127_1881866_0 Pyruvate kinase, alpha/beta domain K00873 - 2.7.1.40 1.19e-199 633.0
TLS2_k127_1881866_1 Protein of unknown function (DUF1036) - - - 0.00000000000000000000000000000000000000000000000000000000000242 212.0
TLS2_k127_1881866_2 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000617 141.0
TLS2_k127_1881866_3 N-formylglutamate amidohydrolase - - - 0.00000000000005415 74.0
TLS2_k127_1881866_4 Ribosomal protein L36 K02919 - - 0.0000000000001675 72.0
TLS2_k127_1891656_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.2 2.895e-245 773.0
TLS2_k127_1896753_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000384 539.0
TLS2_k127_1896753_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005766 510.0
TLS2_k127_1916196_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006937 536.0
TLS2_k127_1916196_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003838 459.0
TLS2_k127_1918141_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 552.0
TLS2_k127_1918141_1 Belongs to the globin family K05916 - 1.14.12.17 0.000000000000003023 83.0
TLS2_k127_1920352_0 Pfam:DUF59 - - - 0.000000000000000000000000000000000000000000000000000006311 196.0
TLS2_k127_1920352_1 Iron-sulphur cluster biosynthesis K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000005666 169.0
TLS2_k127_1920352_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000004652 125.0
TLS2_k127_1920352_3 Belongs to the DEAD box helicase family K03732,K11927 - 3.6.4.13 0.000000000000000000000001456 109.0
TLS2_k127_1932131_0 elongator protein 3 miab nifb - - - 4.252e-237 746.0
TLS2_k127_1932131_1 Protein of unknown function (DUF1622) - - - 0.00000000000006329 73.0
TLS2_k127_1934802_0 Sulfate tungstate uptake family ABC transporter, periplasmic substrate-binding protein K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009335 384.0
TLS2_k127_1934802_1 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001113 279.0
TLS2_k127_1934802_2 von Willebrand factor, type A - - - 0.00000000000000000000000000000000002836 143.0
TLS2_k127_1934802_3 ABC-type tungstate transport system, periplasmic component K05773 - - 0.0000000009855 60.0
TLS2_k127_193588_0 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 392.0
TLS2_k127_193588_1 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 383.0
TLS2_k127_193588_2 DNA polymerase alpha chain like domain K02337 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.00000000000000000000000000000000000000000000000000000005274 204.0
TLS2_k127_1966882_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 456.0
TLS2_k127_1966882_1 Phosphoribulokinase / Uridine kinase family K00855 - 2.7.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 405.0
TLS2_k127_1966882_2 Permease K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 380.0
TLS2_k127_1966882_3 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005651 339.0
TLS2_k127_1966882_4 (ABC) transporter, permease K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007401 322.0
TLS2_k127_196768_0 Cytochrome c - - - 2.09e-231 734.0
TLS2_k127_1983440_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008593 394.0
TLS2_k127_1983440_1 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000000000000000002997 217.0
TLS2_k127_1986506_0 Periplasmic binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007002 343.0
TLS2_k127_1986506_1 Bacterial periplasmic substrate-binding proteins - - - 0.000000000000000000000000000000000000000000000002487 179.0
TLS2_k127_1986506_2 biosynthesis protein E K06139 - - 0.00000000000000000000000000000000000000000001733 164.0
TLS2_k127_1986506_3 integral membrane protein - - - 0.00000000001108 74.0
TLS2_k127_1998305_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008047 533.0
TLS2_k127_1998734_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K12256,K15785 - 2.6.1.113,2.6.1.76 9.527e-253 784.0
TLS2_k127_1998734_1 Glutamine synthetase, catalytic domain K01915 GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 603.0
TLS2_k127_1998734_2 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 553.0
TLS2_k127_1998734_3 -glutamine K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008427 344.0
TLS2_k127_1998734_4 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000428 276.0
TLS2_k127_1998734_5 Glycosyl hydrolases family 15 - - - 0.00000000000000000000000000000000000000000000000000000000008313 205.0
TLS2_k127_1998734_6 Tellurite resistance protein TerB K05801 - - 0.000000000000000000000000000000000000000000000000000000001939 212.0
TLS2_k127_2002410_0 Dihydrodipicolinate reductase, C-terminus K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 359.0
TLS2_k127_2002410_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000072 299.0
TLS2_k127_2002410_2 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002271 282.0
TLS2_k127_2002410_3 Etoposide-induced protein 2.4 (EI24) K06203 - - 0.0000000000000000000000000000000000000000000000000000006288 198.0
TLS2_k127_2002410_4 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000003518 195.0
TLS2_k127_2002410_5 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.00000000000000000000000000000000000000000000002624 179.0
TLS2_k127_2002410_6 Integral membrane protein (DUF2244) - - - 0.0000000000000000000000000000000000000000001726 167.0
TLS2_k127_2002410_7 Diguanylate cyclase - - - 0.0000003094 57.0
TLS2_k127_2002410_8 PFAM response regulator receiver - - - 0.0000004804 57.0
TLS2_k127_2005551_0 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000001043 232.0
TLS2_k127_2005551_1 Universal stress protein UspA - - - 0.000000000000000000000000000000000000000009088 165.0
TLS2_k127_2005551_2 Protein of unknown function (DUF1489) - - - 0.00000000000000000000000000000000000000007328 158.0
TLS2_k127_2014863_0 COG4584 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 608.0
TLS2_k127_2020443_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 1.369e-213 677.0
TLS2_k127_2020443_1 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008496 601.0
TLS2_k127_2020443_2 Belongs to the enoyl-CoA hydratase isomerase family K01782,K01825 - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005388 518.0
TLS2_k127_2020443_3 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000000000000000001009 114.0
TLS2_k127_2038284_0 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.00000000000000000000000000000000000000000000000000000000000000001806 235.0
TLS2_k127_2038284_1 Polysaccharide deacetylase - - - 0.000000000000000000000000004284 123.0
TLS2_k127_2038284_2 Protein of unknown function (DUF2842) - - - 0.0000000000005755 71.0
TLS2_k127_2038284_3 Antibiotic biosynthesis monooxygenase - - - 0.000000002443 63.0
TLS2_k127_2040834_0 Transposase and inactivated derivatives - - - 5.656e-255 794.0
TLS2_k127_2040834_1 insertion sequence ATP-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006143 377.0
TLS2_k127_2040834_2 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001421 270.0
TLS2_k127_2040834_3 Transposase - - - 0.0000000000000000000000000000000000000000477 163.0
TLS2_k127_2040834_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07484 - - 0.0000000000000000000000000000000000005624 140.0
TLS2_k127_2048423_0 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008768 246.0
TLS2_k127_2048423_1 Biopolymer transport protein K03559,K03560 - - 0.000000000000000000000000000000000000000000000000000000000001343 212.0
TLS2_k127_2048423_2 - - - - 0.000000000000000000000000000000000000000002313 160.0
TLS2_k127_2048423_5 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000001625 62.0
TLS2_k127_2064727_0 Protein of unknown function (DUF459) K09795 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005715 280.0
TLS2_k127_2064727_1 glutamate synthase K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000007659 236.0
TLS2_k127_2065250_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006285 522.0
TLS2_k127_2087073_0 phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 6.713e-237 745.0
TLS2_k127_2087073_1 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007963 599.0
TLS2_k127_2087073_2 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005384 258.0
TLS2_k127_2087073_3 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.00000000000000000000000000000000000000004007 158.0
TLS2_k127_2096800_0 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 381.0
TLS2_k127_2096800_1 Competence-damaged protein K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000216 176.0
TLS2_k127_2096800_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.000000000000000000000000000000000000000000002425 166.0
TLS2_k127_2096800_3 Oligoketide cyclase lipid transport protein K18588 - - 0.00000000000000000000000000000000000000000005414 166.0
TLS2_k127_2097068_0 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 480.0
TLS2_k127_2097068_1 glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000003273 269.0
TLS2_k127_2097068_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 GO:0008150,GO:0042221,GO:0046677,GO:0050896 3.6.1.27 0.00000000000000000000000000000000007638 136.0
TLS2_k127_2113879_0 Transposase DDE domain group 1 - - - 2.987e-259 803.0
TLS2_k127_2113879_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009351 497.0
TLS2_k127_2113879_2 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.0000000000000000000000000000000002115 134.0
TLS2_k127_2117713_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 557.0
TLS2_k127_2117713_1 Domain of unknown function (DUF4175) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 387.0
TLS2_k127_2118029_0 Aminotransferase class I and II K14261,K14267 - 2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007644 418.0
TLS2_k127_2118029_1 4TM region of DNA translocase FtsK/SpoIIIE K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 323.0
TLS2_k127_2118029_2 ammonium transporter K03320 - - 0.00000000000000000000000000000000004844 135.0
TLS2_k127_2119487_0 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008109 310.0
TLS2_k127_2119487_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000004107 265.0
TLS2_k127_2119487_2 Ribosome recycling factor K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000005231 244.0
TLS2_k127_2161659_0 inositol mono-phosphatase K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006798 293.0
TLS2_k127_2161659_1 Serine aminopeptidase, S33 K01048 - 3.1.1.5 0.00000000000000000000000000000000000001084 149.0
TLS2_k127_2164037_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1524.0
TLS2_k127_2164037_1 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001289 282.0
TLS2_k127_2164037_2 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000000006641 222.0
TLS2_k127_21845_0 Sigma-54 interaction domain K13599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 324.0
TLS2_k127_21845_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002777 279.0
TLS2_k127_21845_2 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0009399,GO:0071941,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000002596 153.0
TLS2_k127_2211240_0 Peptidase M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009193 512.0
TLS2_k127_2211240_1 - - - - 0.000000000000006787 77.0
TLS2_k127_2216271_0 phosphatase K07093 - - 5.284e-236 752.0
TLS2_k127_2216271_1 Redoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 306.0
TLS2_k127_2216271_2 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 291.0
TLS2_k127_2222719_0 DNA ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 569.0
TLS2_k127_2222719_1 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004043 286.0
TLS2_k127_2222719_2 DNA ligase D K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000003253 267.0
TLS2_k127_2222719_3 Extensin-like protein C-terminus - - - 0.00000000000000000000000000000000000000000000000000000000002799 213.0
TLS2_k127_2222719_4 Wd-40 repeat - - - 0.0000000000000000006669 91.0
TLS2_k127_2231655_0 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 338.0
TLS2_k127_2231655_1 Polysaccharide biosynthesis/export protein K01991 - - 0.0000000000000000000000000000000000000000001335 165.0
TLS2_k127_2245252_0 Histidine kinase K07716 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 424.0
TLS2_k127_2245252_1 gag-polyprotein putative aspartyl protease K06985 - - 0.0000000000000000000000000000000000000000000000000000000002986 214.0
TLS2_k127_2245252_2 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000000000000000001934 167.0
TLS2_k127_2245252_3 Protein of unknown function (DUF1289) K06938 - - 0.0000000000006248 72.0
TLS2_k127_2250362_0 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 331.0
TLS2_k127_2250362_1 Invasion associated locus B - - - 0.000000000000000000000000000000000000000000000000007435 186.0
TLS2_k127_2250362_2 glutamate--cysteine ligase K01919 - 6.3.2.2 0.00000000000003877 74.0
TLS2_k127_2250362_3 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.00000000002023 65.0
TLS2_k127_2280646_0 Phosphoribosyl transferase domain K00760 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8 0.0000000000000000000000000000000000000000000000000000001243 202.0
TLS2_k127_2280646_1 protein conserved in bacteria - - - 0.0000000000000000000000001181 107.0
TLS2_k127_2280646_2 TIGRFAM MJ0042 family finger-like protein - - - 0.000000000002222 78.0
TLS2_k127_2323768_0 Protein of unknown function (DUF1214) - - - 0.00000000000000000000000000000000000000000001244 170.0
TLS2_k127_2323768_1 Protein of unknown function (DUF1491) - - - 0.0000000000000000000000000000004446 125.0
TLS2_k127_2323768_2 integral membrane protein - - - 0.00000000000000000000000000000716 126.0
TLS2_k127_2323768_3 Putative peptidoglycan binding domain - - - 0.0000000000000000000007207 102.0
TLS2_k127_2368942_0 copper-translocating P-type ATPase K01533 - 3.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 524.0
TLS2_k127_2368942_1 Probable molybdopterin binding domain K07141 - 2.7.7.76 0.000000000000000000000000000000000000000000000000001128 193.0
TLS2_k127_2368942_2 helix_turn_helix ASNC type K03719 - - 0.0000000000000000000000000001252 116.0
TLS2_k127_2368942_3 Cytochrome oxidase maturation protein cbb3-type - - - 0.000000000002391 71.0
TLS2_k127_2381813_0 Flavodoxin-like fold K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006394 297.0
TLS2_k127_2381813_1 Belongs to the Nudix hydrolase family - - - 0.00000000000000000000000000000000000000000000436 171.0
TLS2_k127_2381813_2 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000002971 149.0
TLS2_k127_2396757_0 poly(R)-hydroxyalkanoic acid synthase K03821 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 1.938e-264 825.0
TLS2_k127_2396757_1 Putative zinc-binding metallo-peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 431.0
TLS2_k127_2396757_2 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 326.0
TLS2_k127_2403668_0 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 443.0
TLS2_k127_2403668_1 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 437.0
TLS2_k127_2403668_2 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000003189 178.0
TLS2_k127_2403668_3 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.000000000000000000000000000000000000000000000008927 177.0
TLS2_k127_2403668_4 Stringent starvation protein B K09985 - - 0.00000000000000000000000000008768 118.0
TLS2_k127_2403668_5 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.0000000000000000000000000007661 115.0
TLS2_k127_2403668_6 RelE-like toxin of type II toxin-antitoxin system HigB - - - 0.0000000000000000007523 87.0
TLS2_k127_2403668_7 - - - - 0.00000000008397 64.0
TLS2_k127_2417373_0 ATPase involved in DNA repair K03546 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 521.0
TLS2_k127_2417373_1 Mur ligase middle domain K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000001964 180.0
TLS2_k127_2417373_2 ABC-type transport auxiliary lipoprotein component K18480 - - 0.00000000000000000000004374 102.0
TLS2_k127_2417373_3 Histidine Phosphotransfer domain - - - 0.00000000000000000006149 97.0
TLS2_k127_2417373_4 ferredoxin K04755 - - 0.0006648 44.0
TLS2_k127_2427418_0 heme copper-type cytochrome quinol oxidase, subunit 3 K02276 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 418.0
TLS2_k127_2427418_1 Threonine synthase K01733 GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 399.0
TLS2_k127_2427418_2 SURF1 family K14998 GO:0006996,GO:0007005,GO:0008150,GO:0008535,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0033108,GO:0033617,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.000000000000000000000000000000000000000000000000000000000666 214.0
TLS2_k127_2427418_3 Protein of unknown function (DUF983) - - - 0.000000000000000000000000000000000000000002729 158.0
TLS2_k127_2439798_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 3.973e-249 779.0
TLS2_k127_2439798_1 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - 0.00000000000000000000000000000000000000000000811 166.0
TLS2_k127_2439798_2 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.00000000000000000000000000000000000000000004913 164.0
TLS2_k127_24424_0 B3/4 domain K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 587.0
TLS2_k127_24424_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006744 556.0
TLS2_k127_24424_2 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003897 407.0
TLS2_k127_24424_3 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 374.0
TLS2_k127_24424_4 Translation initiation factor IF-3, N-terminal domain K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008136 261.0
TLS2_k127_24424_5 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 0.0000000000000000000000000000000000000000000000000022 184.0
TLS2_k127_24424_6 GrpB protein - - - 0.00000000000000000000000001091 126.0
TLS2_k127_24424_7 Ribosomal protein L35 K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000002996 99.0
TLS2_k127_2470694_0 Bacterial transglutaminase-like cysteine proteinase BTLCP - - - 0.0000000000000000000000000000000000000000000000005045 181.0
TLS2_k127_2470694_1 PFAM type IV pilus assembly PilZ - - - 0.000000000000000000000000000000004873 132.0
TLS2_k127_2470694_2 PAS domain - - - 0.00000000000000000000000000168 118.0
TLS2_k127_2470694_3 PilZ domain - - - 0.00000000000000000000002009 104.0
TLS2_k127_24719_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 466.0
TLS2_k127_24719_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 457.0
TLS2_k127_24719_2 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.00000000000000000000000000000000000000000003675 162.0
TLS2_k127_24719_3 PFAM regulatory protein MerR - - - 0.000000000000000000000000000000000000003922 151.0
TLS2_k127_24719_4 Uncharacterized ACR, COG1399 - - - 0.00000000000000000000000001421 116.0
TLS2_k127_2485178_0 Extracellular solute-binding protein K02035,K13893 - - 4.869e-239 764.0
TLS2_k127_2485178_1 PFAM binding-protein-dependent transport systems inner membrane component K13894 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007362 557.0
TLS2_k127_2485178_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000203 215.0
TLS2_k127_2485178_3 N-terminal TM domain of oligopeptide transport permease C K13895 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000001229 213.0
TLS2_k127_249773_0 UDP-4-amino-4-deoxy-L-arabinose aminotransferase K13308,K20429 GO:0005575,GO:0005576,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043207,GO:0044403,GO:0044419,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0075136,GO:0098771 2.6.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 318.0
TLS2_k127_2503127_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008487 507.0
TLS2_k127_2503127_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000001143 203.0
TLS2_k127_2503127_2 AntiSigma factor - - - 0.000000000000001686 85.0
TLS2_k127_2592109_0 Belongs to the CarB family K01955 - 6.3.5.5 4.607e-271 851.0
TLS2_k127_2592109_1 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000001603 245.0
TLS2_k127_2592109_2 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000007435 82.0
TLS2_k127_2625249_0 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 335.0
TLS2_k127_2625249_1 helix_turn_helix ASNC type - GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009889,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000121 201.0
TLS2_k127_2625249_2 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000000000000000003709 140.0
TLS2_k127_2625249_3 Protein of unknown function (DUF992) - - - 0.000000000000000000000000000009988 124.0
TLS2_k127_263010_0 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT K01499 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.4.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 380.0
TLS2_k127_263010_1 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal K10714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 355.0
TLS2_k127_263010_2 ATP-grasp domain K06913 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008542 290.0
TLS2_k127_263010_3 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004723 276.0
TLS2_k127_263010_4 Belongs to the RimK family K05844 - - 0.000000000000000000000000000000000000000000000000000002788 196.0
TLS2_k127_263010_5 PFAM Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000001744 64.0
TLS2_k127_2670437_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 4.206e-223 709.0
TLS2_k127_2670437_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903,K14067 - 6.2.1.5,6.2.1.9 1.074e-212 665.0
TLS2_k127_2670437_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902,K08692 - 6.2.1.5,6.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006752 513.0
TLS2_k127_2670437_3 PFAM Formiminotransferase-cyclodeaminase - - - 0.0000000000009271 69.0
TLS2_k127_268183_0 RimK-like ATP-grasp domain K05844 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004657 297.0
TLS2_k127_268183_1 Putative ATP-dependant zinc protease - - - 0.0000000000000000000000000000000000000000000002622 172.0
TLS2_k127_268183_2 MTH538 TIR-like domain (DUF1863) - - - 0.00000000000000000000000000000000229 140.0
TLS2_k127_268183_3 Uncharacterized protein conserved in bacteria (DUF2188) - - - 0.0000000000000859 74.0
TLS2_k127_268183_4 Sulfatase-modifying factor enzyme 1 - - - 0.0000000001985 68.0
TLS2_k127_268483_0 Class II Aldolase and Adducin N-terminal domain - - - 2.476e-225 713.0
TLS2_k127_268483_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009623 348.0
TLS2_k127_268483_2 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000001016 243.0
TLS2_k127_268483_3 - - - - 0.0000000000000000004482 98.0
TLS2_k127_268483_4 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.0000000003071 61.0
TLS2_k127_2713925_0 Histidine kinase K15011 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 385.0
TLS2_k127_2713925_1 response regulator K15012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003073 275.0
TLS2_k127_2713925_2 DNA repair protein MmcB-like - - - 0.0000000000000000000000000000000000000000000000008785 179.0
TLS2_k127_2713925_3 DinB superfamily - - - 0.00000000000000000004086 93.0
TLS2_k127_273668_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 5.83e-205 647.0
TLS2_k127_273668_1 L-lysine 6-monooxygenase (NADPH-requiring) K18277 - 1.14.13.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 405.0
TLS2_k127_273668_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000002665 68.0
TLS2_k127_2826947_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1507.0
TLS2_k127_2826947_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 6.544e-254 802.0
TLS2_k127_2826947_2 Flavinator of succinate dehydrogenase K09159 - - 0.00000000000001263 77.0
TLS2_k127_2826947_3 AMP-binding enzyme C-terminal domain - - - 0.00000000003407 70.0
TLS2_k127_2826947_4 AMP-binding enzyme C-terminal domain - - - 0.00001359 48.0
TLS2_k127_2831699_0 Domain of unknown function (DUF3390) K18929 - - 1.197e-197 626.0
TLS2_k127_2831699_1 glycolate oxidase iron-sulfur subunit K18928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 336.0
TLS2_k127_2831699_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006516 301.0
TLS2_k127_2831699_3 LUD domain K00782 - - 0.0000000000000000000000000000000000000000000000000000006092 210.0
TLS2_k127_2831699_4 Cytochrome c K08738 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000002178 105.0
TLS2_k127_2835852_0 Belongs to the glutaminase family K01425 - 3.5.1.2 0.000000000000000000000000000000000000000000000000000000000000001089 230.0
TLS2_k127_2835852_1 HWE histidine kinase - - - 0.000000000000000000000000000000000000000000000002031 184.0
TLS2_k127_2838374_0 Transposase and inactivated derivatives - - - 2.16e-224 701.0
TLS2_k127_2838374_1 insertion sequence ATP-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003363 334.0
TLS2_k127_2838374_2 DNA methylase N-4 N-6 K07316 - 2.1.1.72 0.000000000000000000003681 98.0
TLS2_k127_2838374_3 IstB-like ATP binding N-terminal - - - 0.0002964 44.0
TLS2_k127_2843492_0 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 2.447e-198 632.0
TLS2_k127_2843492_1 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 380.0
TLS2_k127_2843492_2 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.0000000009256 63.0
TLS2_k127_2844204_0 Fumarylacetoacetate (FAA) hydrolase family K01826 - 5.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 355.0
TLS2_k127_2844204_1 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000001347 177.0
TLS2_k127_2847143_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000001265 257.0
TLS2_k127_2847143_1 Aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.0000000000000000000000000002917 119.0
TLS2_k127_2847143_2 aminoglycoside 3-N-acetyltransferase activity K00662 - 2.3.1.81 0.00000000004401 71.0
TLS2_k127_2847143_3 Cyclic nucleotide-monophosphate binding domain - - - 0.0000001158 55.0
TLS2_k127_2847143_4 - - - - 0.000002697 53.0
TLS2_k127_2848592_0 alcohol dehydrogenase K13979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 541.0
TLS2_k127_2848592_1 - - - - 0.00000000000000000000000000000000001689 145.0
TLS2_k127_2855764_0 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 323.0
TLS2_k127_2855764_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000102 274.0
TLS2_k127_2855764_2 import inner membrane translocase, subunit Tim44 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002191 252.0
TLS2_k127_2855764_3 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000000000002829 229.0
TLS2_k127_2855764_4 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.000000000000000000000000000000000000000000000000000000000001097 218.0
TLS2_k127_2855764_5 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000001047 205.0
TLS2_k127_2855764_6 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.0000000000000000000000000000000000000000000000007467 182.0
TLS2_k127_2858352_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 3.684e-272 850.0
TLS2_k127_2858352_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001908 281.0
TLS2_k127_2858352_2 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005233 284.0
TLS2_k127_2858352_3 Linear amide C-N hydrolases, choloylglycine hydrolase family K01442 - 3.5.1.24 0.000000000000000000000000000000000000000000000000000000000000000000003464 239.0
TLS2_k127_2858352_4 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000000003205 201.0
TLS2_k127_2858352_5 ThiS family K03636 - - 0.0000000000000000000000000000283 118.0
TLS2_k127_28592_0 Domain of unknown function (DUF1974) K06445 - - 0.0 1063.0
TLS2_k127_28592_1 CDGSH-type zinc finger. Function unknown. - - - 0.00000000000000000000000000001415 119.0
TLS2_k127_28592_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000001611 63.0
TLS2_k127_2861142_0 Orn DAP Arg decarboxylase 2 K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 389.0
TLS2_k127_2861142_1 Cytochrome c, mono- and diheme variants - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 364.0
TLS2_k127_2861142_2 PFAM Sel1 domain protein repeat-containing protein K07126 - - 0.0000000000000000000000000000000004678 149.0
TLS2_k127_2861142_3 Belongs to the GST superfamily K11209 - - 0.000000000000000001069 86.0
TLS2_k127_287392_0 Glutamate synthase central domain K00265 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 0.0 1596.0
TLS2_k127_287392_1 Glutamate synthase K00266 - 1.4.1.13,1.4.1.14 9.034e-247 768.0
TLS2_k127_287392_2 Protein of unknown function (DUF459) K09795 - - 0.000003172 49.0
TLS2_k127_2874908_0 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 454.0
TLS2_k127_2874908_1 cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004695 282.0
TLS2_k127_2874908_2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000007249 267.0
TLS2_k127_2874908_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000006404 209.0
TLS2_k127_2874908_4 Belongs to the DnaA family - - - 0.00000000000000000000000000000000000000000000000000000007808 205.0
TLS2_k127_2874908_5 Uncharacterized protein conserved in bacteria (DUF2066) - - - 0.0000000000000000000000000000000000005491 154.0
TLS2_k127_2879575_0 Involved in initiation control of chromosome replication K07484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008936 616.0
TLS2_k127_2897340_0 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 413.0
TLS2_k127_2897340_1 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000001503 214.0
TLS2_k127_2897340_2 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000113 196.0
TLS2_k127_2897340_3 Diguanylate cyclase - GO:0000302,GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008081,GO:0008150,GO:0009987,GO:0010035,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042578,GO:0050896,GO:0051716,GO:0052621,GO:0070887,GO:0071111,GO:0071241,GO:0071731,GO:0071732,GO:0097366,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 - 0.0000000000000000000000000000000000000002484 163.0
TLS2_k127_2897340_4 C-terminal region of aryl-sulfatase K01130 - 3.1.6.1 0.0000000000000000577 82.0
TLS2_k127_2897340_5 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.00000000000001423 81.0
TLS2_k127_2897340_6 17 kDa outer membrane surface antigen - - - 0.0006611 48.0
TLS2_k127_290991_0 Signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 469.0
TLS2_k127_290991_1 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008293 348.0
TLS2_k127_290991_2 cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000576 219.0
TLS2_k127_290991_3 peptidase - - - 0.0000000000000000000445 93.0
TLS2_k127_290991_4 Peptidase propeptide and YPEB domain - - - 0.0000000000000000003123 94.0
TLS2_k127_290991_5 PFAM Adenosine AMP deaminase K01488 - 3.5.4.4 0.0000000342 56.0
TLS2_k127_290991_6 - - - - 0.0003927 49.0
TLS2_k127_2910139_0 PFAM Alcohol dehydrogenase GroES-like domain K00344 GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003960,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016651,GO:0016655,GO:0017091,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:1901363 1.6.5.5 0.000000000000000000000000000000000000008327 146.0
TLS2_k127_2910139_1 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.00000000000000000000001217 103.0
TLS2_k127_2910139_2 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000002413 72.0
TLS2_k127_291048_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006876 368.0
TLS2_k127_291048_1 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001469 265.0
TLS2_k127_2914136_0 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 379.0
TLS2_k127_2914136_1 O-methyltransferase K00588 - 2.1.1.104 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006837 286.0
TLS2_k127_2914136_2 SOS response associated peptidase (SRAP) - - - 0.000000000000000000278 89.0
TLS2_k127_2914136_3 Fad linked oxidase K00104 - 1.1.3.15 0.0000000000002497 70.0
TLS2_k127_2926175_0 Transglycosylase SLT domain K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008048 478.0
TLS2_k127_2926175_1 ATP dependent DNA ligase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006922 364.0
TLS2_k127_2926175_2 Protein of unknown function (DUF3072) - - - 0.0000000006496 64.0
TLS2_k127_2926175_3 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.00002997 47.0
TLS2_k127_2926175_4 SnoaL-like domain - - - 0.0006633 48.0
TLS2_k127_2933628_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07638 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005284 518.0
TLS2_k127_2933628_1 Two component transcriptional regulator K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 316.0
TLS2_k127_294363_0 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 420.0
TLS2_k127_294363_1 DJ-1/PfpI family K05520 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004972 272.0
TLS2_k127_294363_2 NUDIX domain K03574 - 3.6.1.55 0.00000000000000000000000000000000001198 140.0
TLS2_k127_294363_3 High-affinity nickel-transport protein K08970 - - 0.000000000000000000000000000000001949 133.0
TLS2_k127_294363_4 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.0000000000000000000000000004292 118.0
TLS2_k127_2953395_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 1.666e-254 792.0
TLS2_k127_2955347_0 FMN-dependent dehydrogenase K00467 - 1.13.12.4 3.84e-200 631.0
TLS2_k127_2955347_1 Protein of unknown function (DUF2852) - - - 0.00000000000000000000000000000000000000003707 156.0
TLS2_k127_2955987_0 Belongs to the heme-copper respiratory oxidase family K00404 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 8.218e-293 906.0
TLS2_k127_2955987_1 TIGRFAM cytochrome c oxidase, cbb3-type, subunit II K00405 - - 0.00000000000000000000000000000000000000000000000000000000001134 207.0
TLS2_k127_2955987_2 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000000000000003537 160.0
TLS2_k127_2955987_3 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000001744 118.0
TLS2_k127_2967990_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 464.0
TLS2_k127_2967990_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007045 380.0
TLS2_k127_2967990_10 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000003575 110.0
TLS2_k127_2967990_11 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000005499 91.0
TLS2_k127_2967990_2 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 369.0
TLS2_k127_2967990_3 Ribosomal protein L4/L1 family K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 283.0
TLS2_k127_2967990_4 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000001517 220.0
TLS2_k127_2967990_5 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000001503 194.0
TLS2_k127_2967990_6 Ribosomal protein S19 K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000000000000006896 175.0
TLS2_k127_2967990_7 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000008317 145.0
TLS2_k127_2967990_8 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000003984 129.0
TLS2_k127_2967990_9 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000799 130.0
TLS2_k127_2974381_0 Cytochrome P450 K15629 - 1.11.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 434.0
TLS2_k127_2974381_1 Cytochrome C and Quinol oxidase polypeptide I K15408 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006117 288.0
TLS2_k127_2974381_2 cytochrome C oxidase K02351 - - 0.0000000000000000000000000000000000000000000000002424 189.0
TLS2_k127_2974381_3 - - - - 0.000000000000000000003841 97.0
TLS2_k127_2992962_0 PFAM Peptidase M1 membrane alanine aminopeptidase K01256 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006222 527.0
TLS2_k127_2992962_1 - - - - 0.00000000000000000000000000000000000000000000000000001785 195.0
TLS2_k127_2992962_3 - - - - 0.0000000004215 68.0
TLS2_k127_2993052_0 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000006338 173.0
TLS2_k127_2993052_1 Chain length determinant protein - - - 0.00000000000000000000000000000008744 140.0
TLS2_k127_2993052_2 Chain length determinant protein - - - 0.000000000000000000000000000002049 127.0
TLS2_k127_2993052_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000001448 91.0
TLS2_k127_2993052_4 Acetyltransferase (GNAT) domain - - - 0.0000000003602 70.0
TLS2_k127_2993052_5 protein involved in - - - 0.000000005486 64.0
TLS2_k127_3000443_0 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009405 396.0
TLS2_k127_3000443_1 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000004424 223.0
TLS2_k127_3000443_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 GO:0008150,GO:0042221,GO:0046677,GO:0050896 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000005261 213.0
TLS2_k127_3045339_0 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) K00164 - 1.2.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 505.0
TLS2_k127_3045339_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 471.0
TLS2_k127_3045339_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000009002 256.0
TLS2_k127_3071034_0 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 319.0
TLS2_k127_3071034_1 Scaffold protein Nfu NifU - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008861 281.0
TLS2_k127_3071034_2 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000000002615 203.0
TLS2_k127_3071034_3 Glycoprotease family K01409,K14742 - 2.3.1.234 0.00000000000000000000000000000000000002232 156.0
TLS2_k127_3071034_4 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.0000000000000001327 89.0
TLS2_k127_3082510_0 helicase superfamily c-terminal domain K17675 - 3.6.4.13 1.152e-286 900.0
TLS2_k127_3082510_1 CHASE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 478.0
TLS2_k127_3082510_2 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit K04762 - - 0.0000000000000000000000001198 109.0
TLS2_k127_3104760_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 9.71e-231 721.0
TLS2_k127_3104760_1 Protein of unknown function (DUF1223) - - - 0.000000000000000000000000000000000000000000003611 169.0
TLS2_k127_3104760_2 acetyltransferase - - - 0.00000000000000000000000000000000000000001916 160.0
TLS2_k127_3107735_0 Sugar transferase K03606,K20997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002305 261.0
TLS2_k127_3107735_1 polysaccharide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000001211 188.0
TLS2_k127_3107735_2 Methyltransferase domain K00568 - 2.1.1.222,2.1.1.64 0.000000007473 65.0
TLS2_k127_312299_0 Proton-conducting membrane transporter K05568 - - 3.298e-196 622.0
TLS2_k127_312299_1 Proton-conducting membrane transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 557.0
TLS2_k127_312299_2 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 436.0
TLS2_k127_312299_3 PFAM NADH-ubiquinone oxidoreductase chain 4L K05567 - - 0.00000000000000000001152 93.0
TLS2_k127_312299_4 - - - - 0.000000000000000001326 85.0
TLS2_k127_312299_5 Phage integrase family - - - 0.000000000000000001707 87.0
TLS2_k127_314335_0 YmdB-like protein K09769 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 416.0
TLS2_k127_314335_1 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 389.0
TLS2_k127_314335_2 TIGRFAM DNA-binding regulatory protein, YebC PmpR family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003416 336.0
TLS2_k127_314335_3 Sel1-like repeats. K07126 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001407 250.0
TLS2_k127_314335_4 Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 0.00000000000000000000000000000000000000000000000000000004178 206.0
TLS2_k127_314335_5 Thiamine monophosphate synthase K00788 - 2.5.1.3 0.00000000000000000000000000000004976 132.0
TLS2_k127_314335_6 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000000000265 95.0
TLS2_k127_314335_7 Domain of unknown function (DUF4164) - - - 0.00005458 49.0
TLS2_k127_3182868_0 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000507 379.0
TLS2_k127_3182868_1 Domain of unknown function (DUF3597) - - - 0.000000000000000000000001183 111.0
TLS2_k127_3182868_2 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.000000000000001103 79.0
TLS2_k127_3211074_0 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032,K13896 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 5.344e-251 784.0
TLS2_k127_3211074_1 PFAM NLP P60 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 302.0
TLS2_k127_3211074_2 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.000000000000000000000000000000000000002548 148.0
TLS2_k127_3220823_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1359.0
TLS2_k127_3220823_1 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000000000000000000000005147 203.0
TLS2_k127_3224191_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 353.0
TLS2_k127_3224191_1 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 299.0
TLS2_k127_3224191_2 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K17364 - 1.5.1.47 0.0000000000000000000000000000000000000000000000000000000000003927 216.0
TLS2_k127_3224191_4 Domain of unknown function (DUF4864) - - - 0.00004708 53.0
TLS2_k127_3245774_0 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 424.0
TLS2_k127_3245774_1 Protein of unknown function (DUF1465) K13592 - - 0.000000000000000000000000000000000000000000001026 171.0
TLS2_k127_3245774_2 Ribosomal protein L31 K02909 - - 0.000000000000000000000000000000004058 131.0
TLS2_k127_3245774_3 Protein of unknown function (DUF1013) K09987 - - 0.000000000002485 68.0
TLS2_k127_3245774_4 Protein of unknown function (DUF1192) - - - 0.00002397 49.0
TLS2_k127_3259320_0 ABC transporter K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005788 335.0
TLS2_k127_3259320_1 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000007495 182.0
TLS2_k127_3259320_2 O-Antigen Polymerase K02847 - - 0.00000000000000000000000000002876 132.0
TLS2_k127_3259320_3 Sulfotransferase family - - - 0.000000000000002797 85.0
TLS2_k127_3320106_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000709 579.0
TLS2_k127_3320106_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 497.0
TLS2_k127_3349125_0 helicase superfamily c-terminal domain K17675 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000001808 265.0
TLS2_k127_3349125_1 Esterase-like activity of phytase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008529 271.0
TLS2_k127_3349125_2 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000002204 164.0
TLS2_k127_3349125_3 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000005692 135.0
TLS2_k127_3349125_4 SMART von Willebrand factor type A K09883 - 6.6.1.2 0.00000000000000000000001797 100.0
TLS2_k127_3361437_0 Belongs to the GcvT family K00605 - 2.1.2.10 0.0 1177.0
TLS2_k127_3361437_1 Linear amide C-N hydrolases, choloylglycine hydrolase family K01442 - 3.5.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 351.0
TLS2_k127_3361437_2 Haloacid dehalogenase-like hydrolase K01101,K02566 - 3.1.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 310.0
TLS2_k127_3361437_3 flavoprotein involved in K transport K18277 - 1.14.13.148 0.0000000000000000000000000000009564 122.0
TLS2_k127_3374207_0 Glucose sorbosone K00117,K21430 - 1.1.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 410.0
TLS2_k127_3374207_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007844 331.0
TLS2_k127_3374207_2 - - - - 0.0000000000000000000000000000000000605 137.0
TLS2_k127_3427721_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 1.173e-243 767.0
TLS2_k127_3427721_1 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000004115 164.0
TLS2_k127_3427721_2 PFAM Mo-dependent nitrogenase - - - 0.0000000000000002114 79.0
TLS2_k127_3460048_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009569 452.0
TLS2_k127_3460048_1 oxidation protein SoxZ K17226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009736 267.0
TLS2_k127_3466777_0 PFAM LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003116 274.0
TLS2_k127_3466777_1 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000005542 163.0
TLS2_k127_3485101_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004862 591.0
TLS2_k127_3485101_1 Beta-lactamase K18988 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006848 451.0
TLS2_k127_3485101_2 ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003363 371.0
TLS2_k127_3485101_3 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044424,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563 - 0.0000000000000000000000000000000000000000000000000000001518 202.0
TLS2_k127_3485101_4 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000000000000000000000000005326 201.0
TLS2_k127_3485101_5 3'-5' exonuclease K03684 - 3.1.13.5 0.00000000000000000000000000000000000000001032 154.0
TLS2_k127_3485101_6 OstA-like protein K09774 - - 0.0000000000000000000000000000001007 137.0
TLS2_k127_3485101_7 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.0000000000000000000000000000001381 130.0
TLS2_k127_3485101_8 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.000000000000000000000000003603 121.0
TLS2_k127_3485101_9 Protein of unknown function (DUF1150) - - - 0.000000000000000005032 87.0
TLS2_k127_3545925_0 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.000000000000000000000000000000000000000000000000002634 194.0
TLS2_k127_3545925_1 Wd-40 repeat - - - 0.00000000000000000000000000000000009417 143.0
TLS2_k127_3545925_2 YGGT family K02221 - - 0.0000002931 52.0
TLS2_k127_3547872_0 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0003674,GO:0003824,GO:0004735,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003238 273.0
TLS2_k127_3547872_1 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000001654 176.0
TLS2_k127_3547872_2 Signal transduction histidine kinase K07638 - 2.7.13.3 0.00000000000000000002027 91.0
TLS2_k127_3547872_3 Putative bacterial sensory transduction regulator - - - 0.00000000000000007102 80.0
TLS2_k127_3574604_0 recombinase activity - GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003279 587.0
TLS2_k127_3574604_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 476.0
TLS2_k127_360842_0 COG3666 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 608.0
TLS2_k127_360842_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000001464 143.0
TLS2_k127_360842_2 DNA methylAse - - - 0.000000000001478 69.0
TLS2_k127_360957_0 Universal stress protein family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005772 261.0
TLS2_k127_360957_1 Hydantoinase B/oxoprolinase K01469 - 3.5.2.9 0.000000000001687 67.0
TLS2_k127_360957_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - 0.0004566 43.0
TLS2_k127_364332_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 541.0
TLS2_k127_364332_1 Ankyrin repeats (3 copies) K06867,K21440 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001892 288.0
TLS2_k127_364332_2 cytochrome - - - 0.0000000005226 60.0
TLS2_k127_364332_3 AI-2E family transporter - - - 0.00000006154 56.0
TLS2_k127_3644888_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1091.0
TLS2_k127_36453_0 cystathionine beta-lyase K01760 - 4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 535.0
TLS2_k127_36453_1 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000857 261.0
TLS2_k127_36453_2 ETC complex I subunit K00329 - 1.6.5.3 0.000000002313 58.0
TLS2_k127_372850_0 PFAM transposase IS66 K07484 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 536.0
TLS2_k127_372850_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07484 - - 0.0000000000000000000000000000000000000000000000000000000000338 206.0
TLS2_k127_372850_2 Evidence 4 Homologs of previously reported genes of K07483 - - 0.0000000000000000004006 91.0
TLS2_k127_372850_3 Transposase mutator type - - - 0.0000000000000000004564 87.0
TLS2_k127_3746767_0 Protein of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008031 326.0
TLS2_k127_376437_0 Alpha-2-Macroglobulin K06894 - - 0.0 1306.0
TLS2_k127_376437_1 Beta-lactamase class C - - - 0.00000000000000000000000694 102.0
TLS2_k127_3777561_0 Belongs to the prokaryotic GSH synthase family K01920 GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002771 483.0
TLS2_k127_3777561_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 304.0
TLS2_k127_3777561_2 LppC putative lipoprotein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001981 255.0
TLS2_k127_3777561_3 SnoaL-like polyketide cyclase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000001175 164.0
TLS2_k127_3777561_4 Belongs to the UPF0102 family K07460 - - 0.0000000000000000000000001508 111.0
TLS2_k127_3777561_5 Histidine kinase-like ATPases - - - 0.000000000001081 73.0
TLS2_k127_3777561_6 2TM domain - - - 0.00003793 54.0
TLS2_k127_3777561_7 Helix-turn-helix XRE-family like proteins - - - 0.0002875 51.0
TLS2_k127_3777561_8 Histidine kinase - - - 0.0009065 44.0
TLS2_k127_3788462_0 ABC 3 transport family K02075 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005214 365.0
TLS2_k127_3788462_1 ABC transporter K02074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007095 309.0
TLS2_k127_3788462_2 Belongs to the bacterial solute-binding protein 9 family K02077,K09815 - - 0.0000000000000000000000000000000000000000000000000000003585 202.0
TLS2_k127_3788462_3 Belongs to the Fur family K09823 - - 0.00002848 47.0
TLS2_k127_3793227_0 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 588.0
TLS2_k127_3793227_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 570.0
TLS2_k127_3793227_2 Predicted small integral membrane protein (DUF2165) - - - 0.00000000000000000000000000000000000000000000000000000000000000009553 228.0
TLS2_k127_3793227_3 Cupin - - - 0.0000000000000000000000000000000000000000000000000000001705 196.0
TLS2_k127_3793227_4 PFAM YbaK prolyl-tRNA K19055 - - 0.00000000000000000000000000000000000000000000000000005117 194.0
TLS2_k127_3793227_5 manually curated - - - 0.0000000000000000000000000000001195 126.0
TLS2_k127_3793227_6 acetolactate synthase K01653 - 2.2.1.6 0.00000000000000007102 80.0
TLS2_k127_3793227_7 - - - - 0.0000000000001285 77.0
TLS2_k127_3793227_8 Protein of unknown function (DUF1236) - - - 0.0000005584 60.0
TLS2_k127_3802643_0 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000003733 213.0
TLS2_k127_3802643_1 Diguanylate cyclase - - - 0.000000000000000000001909 102.0
TLS2_k127_3802643_2 Ribosomal L32p protein family K02911 - - 0.000000000000000002467 97.0
TLS2_k127_3810084_0 Belongs to the thiolase family K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 606.0
TLS2_k127_3810084_1 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 564.0
TLS2_k127_3810084_10 Sulfotransferase family - - - 0.00055 46.0
TLS2_k127_3810084_2 Acetoacetyl-CoA reductase K00023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 332.0
TLS2_k127_3810084_3 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006841 320.0
TLS2_k127_3810084_4 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000743 279.0
TLS2_k127_3810084_5 synthesis repressor PhaR - - - 0.000000000000000000000000000000000000000000000000000000000000000714 225.0
TLS2_k127_3810084_6 GntR family K13637 - - 0.0000000000000000000000000000000000000000000000000000000003357 211.0
TLS2_k127_3810084_7 Cupin superfamily (DUF985) K09705 - - 0.0000000000000000000000000000000000000000000000002716 193.0
TLS2_k127_3810084_8 methionine biosynthesis protein (MetW) - - - 0.0000000000000000000000000001675 115.0
TLS2_k127_3810084_9 Transposase DDE domain - - - 0.00000002551 64.0
TLS2_k127_3827310_0 NMT1/THI5 like K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 344.0
TLS2_k127_3827310_1 PFAM response regulator receiver K07665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006107 280.0
TLS2_k127_3827310_2 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007551 278.0
TLS2_k127_3827310_3 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002284 264.0
TLS2_k127_3836178_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 3.973e-217 680.0
TLS2_k127_3836178_1 COG4663 TRAP-type mannitol chloroaromatic compound transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 582.0
TLS2_k127_3836178_2 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000006421 158.0
TLS2_k127_3836178_3 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000002858 98.0
TLS2_k127_3837849_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 588.0
TLS2_k127_3837849_1 permease YjgP YjgQ family protein K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008484 300.0
TLS2_k127_3837849_2 Nucleoside triphosphate pyrophosphohydrolase K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 0.00000000000000000000000000000000000000000000000000000000004062 210.0
TLS2_k127_3853550_0 Calcineurin-like phosphoesterase K07313 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000009325 242.0
TLS2_k127_3853550_1 Protein of unknown function (DUF1134) - - - 0.00000000000000000000000000000000008913 134.0
TLS2_k127_3853550_2 motor activity - - - 0.00000000000000002236 94.0
TLS2_k127_3859537_0 Substrate binding domain of ABC-type glycine betaine transport system K02002 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 543.0
TLS2_k127_3859537_1 ATPases associated with a variety of cellular activities K02000 - 3.6.3.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 449.0
TLS2_k127_3861437_0 Conserved region in glutamate synthase K22083 - 2.1.1.21 1.841e-264 821.0
TLS2_k127_3861437_1 COG0004 Ammonia permease - - - 2.76e-231 721.0
TLS2_k127_3861437_2 Glutamine synthetase, catalytic domain K01915,K01949 - 6.3.1.2,6.3.4.12 3.812e-208 654.0
TLS2_k127_3861437_3 COG0070 Glutamate synthase domain 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 348.0
TLS2_k127_3861437_4 - - - - 0.00000000000000000000000000000000000000000000000000000001105 211.0
TLS2_k127_3861437_5 - - - - 0.00000000000000000000000000000000008799 140.0
TLS2_k127_3861437_6 - - - - 0.000000000000007397 77.0
TLS2_k127_3881445_0 Diguanylate cyclase phosphodiesterase with PAS PAC K13245 - 3.1.4.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 519.0
TLS2_k127_3881445_1 Belongs to the peptidase M16 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 308.0
TLS2_k127_3881445_2 Acetyltransferases, including N-acetylases of ribosomal proteins K03790 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000000000000000000000001014 258.0
TLS2_k127_3887802_0 Tetratricopeptide repeat K03671,K05838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 353.0
TLS2_k127_3887802_1 YbaK prolyl-tRNA synthetase associated K19055 - - 0.000000000000000000000000000000000609 133.0
TLS2_k127_3887802_2 peptidase S16 K01338,K07157 - 3.4.21.53 0.00000000000000006382 83.0
TLS2_k127_3890241_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 536.0
TLS2_k127_3890241_1 Sigma-70, region 4 K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 460.0
TLS2_k127_3890241_2 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000001188 160.0
TLS2_k127_3890241_3 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.0000002018 53.0
TLS2_k127_3892150_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 9.266e-307 954.0
TLS2_k127_3892150_1 Peptidase S24-like K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 361.0
TLS2_k127_3892150_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008075 330.0
TLS2_k127_3892150_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000001927 236.0
TLS2_k127_3892150_4 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000000000000000000000000000005153 201.0
TLS2_k127_3892150_5 Protein conserved in bacteria K09928 - - 0.00000000000000000000000000000000000000000000002358 178.0
TLS2_k127_3892150_6 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000135 110.0
TLS2_k127_3892172_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004693 602.0
TLS2_k127_3892172_1 Protein of unknown function - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009905 477.0
TLS2_k127_3892172_2 Uncharacterized protein family (UPF0051) K09014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007018 410.0
TLS2_k127_3892172_3 X-Pro dipeptidyl-peptidase (S15 family) K07018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007971 358.0
TLS2_k127_3892172_4 COG1104 Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000797 363.0
TLS2_k127_3894280_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 1.819e-220 690.0
TLS2_k127_3894280_1 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 407.0
TLS2_k127_3894280_2 Acyl-carrier-protein S-malonyltransferase K00645 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 392.0
TLS2_k127_3894280_3 PFAM short-chain dehydrogenase reductase SDR K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 367.0
TLS2_k127_3894280_4 Phosphopantetheine attachment site K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000009884 145.0
TLS2_k127_3894280_5 Domain of unknown function (DUF1732) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000004282 100.0
TLS2_k127_3896321_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 341.0
TLS2_k127_3896321_1 Pyrrolo-quinoline quinone - - - 0.00000000000000001231 89.0
TLS2_k127_3896321_2 OsmC-like protein - - - 0.0000000005157 63.0
TLS2_k127_3896321_3 - - - - 0.000001052 51.0
TLS2_k127_3901437_0 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 407.0
TLS2_k127_3901437_1 NnrU protein - - - 0.0000000000000000000000000000000000000000000000000000000001313 208.0
TLS2_k127_3901437_2 Tetratricopeptide repeat-like domain - - - 0.00000000000000000000000000000000000000000001471 169.0
TLS2_k127_3902087_0 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 559.0
TLS2_k127_3902087_1 Opacity protein and related surface antigens - - - 0.0000000000000000000000000000000000000000000000003047 182.0
TLS2_k127_3902087_2 Opacity protein and related surface antigens - - - 0.000000000008587 68.0
TLS2_k127_3909273_0 ankyrin repeat K06867,K08738,K21440 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000849 575.0
TLS2_k127_3909273_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000595 275.0
TLS2_k127_3909273_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000004868 178.0
TLS2_k127_3909273_3 PQQ-like domain - - - 0.0000000000000000000008381 95.0
TLS2_k127_3909273_4 Periplasmic binding protein - - - 0.00005735 51.0
TLS2_k127_3919552_0 fructose-bisphosphate aldolase K01623 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 517.0
TLS2_k127_3919552_1 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 388.0
TLS2_k127_3919552_2 Protein of unknown function (DUF2950) - - - 0.00000000000000000000000000000000000000000000000000000000000000000003137 236.0
TLS2_k127_3919552_3 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000002198 171.0
TLS2_k127_3919552_4 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000003298 109.0
TLS2_k127_393225_0 CoA binding domain K09181 - - 9.39e-304 956.0
TLS2_k127_393225_1 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 596.0
TLS2_k127_393225_2 Histidine kinase K14986 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 513.0
TLS2_k127_393225_3 helix_turn_helix, Lux Regulon K14987 - - 0.0000000000000000000000000000000000000000000000000000000000000000001995 239.0
TLS2_k127_393225_4 helix_turn_helix, cAMP Regulatory protein K01420,K15861 - - 0.0000000000000000000000000000000000000000000000006601 183.0
TLS2_k127_393225_5 LapD/MoxY periplasmic domain K07675 - 2.7.13.3 0.0000000000000000000000000000000000000000000007344 174.0
TLS2_k127_393225_6 Protein required for attachment to host cells - - - 0.00000000000000000000000000007845 123.0
TLS2_k127_393225_7 Cytochrome c - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000005747 79.0
TLS2_k127_3943502_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 577.0
TLS2_k127_3943502_1 Belongs to the FPP GGPP synthase family K02523 GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009355 456.0
TLS2_k127_3943502_2 Methyltransferase small domain K15460 - 2.1.1.223 0.000000000000000000000000000000000000000000000000000000000000000000273 238.0
TLS2_k127_3943502_3 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000004078 241.0
TLS2_k127_3943502_4 Putative prokaryotic signal transducing protein - - - 0.0000000000000000002253 91.0
TLS2_k127_3963465_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 3.413e-285 887.0
TLS2_k127_3963465_1 Cellulose biosynthesis protein BcsQ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 366.0
TLS2_k127_3963465_2 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 297.0
TLS2_k127_3963465_3 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000005283 266.0
TLS2_k127_3963465_4 Phosphoribosyl transferase domain K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000001123 233.0
TLS2_k127_3963465_5 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.000000000000000000000000000000000000000000000000000000000323 209.0
TLS2_k127_3963465_6 Lipopolysaccharide-assembly K03643 - - 0.000000000000000000000000000000000000004667 152.0
TLS2_k127_3963465_7 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000001648 123.0
TLS2_k127_3963465_8 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.00000004781 54.0
TLS2_k127_3964684_0 Alpha beta hydrolase fold K01048 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005691 332.0
TLS2_k127_3964684_1 PFAM Inositol monophosphatase K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.00000000000000000000000000000000000000000000000000000000000000000000001483 246.0
TLS2_k127_3964684_2 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.000000000000000000000000000000000000000000000000000000001398 206.0
TLS2_k127_3985577_0 Protein-glutamate methylesterase K13924 - 2.1.1.80,3.1.1.61 0.0 1674.0
TLS2_k127_3985577_1 Hsp20/alpha crystallin family K04080 - - 0.0000000000000000000000000000000000000000000000000129 184.0
TLS2_k127_3985577_2 Transposase - - - 0.000000000000000000000000000000000000000000000006852 188.0
TLS2_k127_3985577_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000001093 103.0
TLS2_k127_3985577_5 Response regulator, receiver - - - 0.00000000008138 63.0
TLS2_k127_3985577_6 IS66 C-terminal element - - - 0.0002776 53.0
TLS2_k127_3990940_0 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 531.0
TLS2_k127_3990940_1 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000000002628 171.0
TLS2_k127_3990940_2 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.00000000000000000000000000000000000149 140.0
TLS2_k127_400602_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 2.59e-207 657.0
TLS2_k127_400602_1 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.00000000000000000000000000000000000000003737 155.0
TLS2_k127_400602_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07032 - - 0.000000000000000000000000000000000000008714 149.0
TLS2_k127_400602_3 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.0000000000000000001652 94.0
TLS2_k127_4019465_0 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 479.0
TLS2_k127_4019465_1 - - - - 0.00000000000000000000000000000000000001525 151.0
TLS2_k127_4019465_2 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000001437 145.0
TLS2_k127_4019465_3 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000002499 118.0
TLS2_k127_4019793_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 3.776e-262 817.0
TLS2_k127_4019793_1 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000008822 265.0
TLS2_k127_4030206_0 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006625 323.0
TLS2_k127_4030206_1 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005922 242.0
TLS2_k127_4030206_2 Large extracellular alpha-helical protein - - - 0.000000000000009964 81.0
TLS2_k127_4030206_3 Belongs to the pirin family K06911 - - 0.0000000000000128 73.0
TLS2_k127_4030206_4 pyrroloquinoline quinone binding - - - 0.00000000007479 70.0
TLS2_k127_4058032_0 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 2.592e-295 914.0
TLS2_k127_4058032_1 ArgK protein K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 360.0
TLS2_k127_4064194_0 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 351.0
TLS2_k127_4064194_1 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.0000000000000000000000000000000000000000000000000000000000000001787 225.0
TLS2_k127_4064194_2 COG2207 AraC-type DNA-binding domain-containing proteins - - - 0.0000000000000000000000000000000000000000000000108 177.0
TLS2_k127_4064194_3 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.000000000000000000000000000000000000000000005891 166.0
TLS2_k127_4064194_4 Helix-turn-helix domain - - - 0.000000000000000000000000000000009568 130.0
TLS2_k127_4064194_5 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000001044 102.0
TLS2_k127_4064194_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000001647 65.0
TLS2_k127_4076697_0 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 295.0
TLS2_k127_4096249_0 Serine carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 516.0
TLS2_k127_4096249_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0004646 47.0
TLS2_k127_4170219_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 592.0
TLS2_k127_4170219_1 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001664 272.0
TLS2_k127_4170221_0 Belongs to the ALAD family K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008437 464.0
TLS2_k127_4170221_1 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 282.0
TLS2_k127_4170221_2 Enoyl-CoA hydratase/isomerase K01692,K05605 - 3.1.2.4,4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005651 283.0
TLS2_k127_4170221_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000001263 203.0
TLS2_k127_4170221_4 Extensin family - - - 0.0000000000000000000000000000000000000000000000000754 191.0
TLS2_k127_4170221_5 RDD family - - - 0.00000000000000000000000000000000000000664 150.0
TLS2_k127_4209054_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 1.2e-248 775.0
TLS2_k127_4209054_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005596 433.0
TLS2_k127_4209054_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000001925 219.0
TLS2_k127_4268223_0 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 605.0
TLS2_k127_4268223_1 Formate--tetrahydrofolate ligase K01938 - 6.3.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006597 596.0
TLS2_k127_4347267_0 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 387.0
TLS2_k127_4347267_1 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005557 389.0
TLS2_k127_4347267_2 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005491 331.0
TLS2_k127_4347267_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000758 312.0
TLS2_k127_4347267_4 Nitroreductase family K04719 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016491,GO:0016705,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.79 0.000000000000000000000000000000000000000000000000000029 190.0
TLS2_k127_4347267_5 - - - - 0.00000000000000001093 91.0
TLS2_k127_440261_0 exporters of the RND superfamily K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004601 424.0
TLS2_k127_440261_1 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007568 285.0
TLS2_k127_440261_2 Periplasmic or secreted lipoprotein - - - 0.00000000000000000000000000000008277 130.0
TLS2_k127_4415684_0 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 563.0
TLS2_k127_4415684_1 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 379.0
TLS2_k127_4415684_10 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000002912 167.0
TLS2_k127_4415684_11 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000001822 151.0
TLS2_k127_4415684_12 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000015 144.0
TLS2_k127_4415684_13 Transcriptional regulator - - - 0.0000000000000000000000000000198 127.0
TLS2_k127_4415684_14 - - - - 0.00000000000000000000569 92.0
TLS2_k127_4415684_15 Helix-hairpin-helix motif K02237 - - 0.000000000000000008809 83.0
TLS2_k127_4415684_16 MacB-like periplasmic core domain - - - 0.0007856 46.0
TLS2_k127_4415684_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 360.0
TLS2_k127_4415684_3 Enolase C-terminal domain-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000172 288.0
TLS2_k127_4415684_4 PFAM Major Facilitator Superfamily K08191 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009122 272.0
TLS2_k127_4415684_5 domain, Protein K20276 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001509 284.0
TLS2_k127_4415684_6 COG3119 Arylsulfatase A K01138 - - 0.000000000000000000000000000000000000000000000000000000000002303 211.0
TLS2_k127_4415684_7 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000004412 218.0
TLS2_k127_4415684_8 Protein of unknown function (DUF1501) - - - 0.0000000000000000000000000000000000000000000000000006615 204.0
TLS2_k127_4415684_9 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000002707 193.0
TLS2_k127_4433659_0 Carboxyl transferase domain K01966 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0031974,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0070013,GO:0071704,GO:0072329,GO:1901575 2.1.3.15,6.4.1.3 0.00000000000000000000000000000000000000000000004104 169.0
TLS2_k127_4433659_1 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000607 160.0
TLS2_k127_4433659_3 Cytochrome c - - - 0.0000000000000000008978 89.0
TLS2_k127_4482410_0 Amino acid regulated cytosolic protein K06918 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 437.0
TLS2_k127_4482410_1 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.000000000000000000000000000000000000000000000000000000000000002329 227.0
TLS2_k127_4482410_2 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000000000000000000000000000000000000007926 222.0
TLS2_k127_4572045_0 lipid A ABC exporter family, fused ATPase and inner membrane subunits K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 577.0
TLS2_k127_4572045_1 Protein of unknown function (DUF861) - - - 0.000000000000000000000003647 101.0
TLS2_k127_4677733_0 Glutamine amidotransferase domain K22081 - 2.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 408.0
TLS2_k127_4677733_1 Transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002282 280.0
TLS2_k127_4677733_2 GXGXG motif K22082 - 2.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000008592 253.0
TLS2_k127_4677733_3 helix-turn-helix- domain containing protein AraC type - - - 0.0000000000000000000000000000000000000000000000000000000000000002676 225.0
TLS2_k127_4677733_4 - - - - 0.0000001968 55.0
TLS2_k127_4683410_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 467.0
TLS2_k127_4683410_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007995 297.0
TLS2_k127_4683410_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K09565 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000003363 251.0
TLS2_k127_4683410_3 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000001063 234.0
TLS2_k127_4683410_4 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000009314 211.0
TLS2_k127_4690981_0 Belongs to the aldehyde dehydrogenase family K00128,K09472 - 1.2.1.3,1.2.1.99 6.339e-257 799.0
TLS2_k127_4690981_1 Belongs to the aldehyde dehydrogenase family K00135,K15786 - 1.2.1.16,1.2.1.20,1.2.1.79 2.345e-238 744.0
TLS2_k127_4690981_2 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052,K11072,K11076 - 3.6.3.31 1.507e-195 626.0
TLS2_k127_4690981_3 Required for the activity of the bacterial periplasmic transport system of putrescine K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 567.0
TLS2_k127_4690981_4 putrescine K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007665 475.0
TLS2_k127_4690981_5 Binding-protein-dependent transport system inner membrane component K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 433.0
TLS2_k127_4690981_6 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822,K00833 - 2.6.1.18,2.6.1.62 0.000000000000000000000000001317 123.0
TLS2_k127_4690981_7 Glutamine synthetase, catalytic domain K01915 GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575 6.3.1.2 0.0000000000000000002851 87.0
TLS2_k127_4694384_0 Arginase family K01480 - 3.5.3.11 4.158e-233 725.0
TLS2_k127_4694384_1 Protein of unknown function (DUF1116) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004972 517.0
TLS2_k127_4694384_10 Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A K02228 - 2.1.1.152 0.000000000000000000505 87.0
TLS2_k127_4694384_11 - - - - 0.00000000000001005 82.0
TLS2_k127_4694384_2 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009429 437.0
TLS2_k127_4694384_3 Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 311.0
TLS2_k127_4694384_4 Flavodoxin-like fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000458 302.0
TLS2_k127_4694384_5 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006424 255.0
TLS2_k127_4694384_6 HupE / UreJ protein K03192 - - 0.0000000000000000000000000000000000000000000000000000000000000000001882 236.0
TLS2_k127_4694384_7 glutamine synthetase K01915 - 6.3.1.2 0.000000000000000000000000000000000000001505 154.0
TLS2_k127_4694384_8 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000001055 154.0
TLS2_k127_4694384_9 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000007774 148.0
TLS2_k127_4696277_0 Amidohydrolase family K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 580.0
TLS2_k127_4696277_1 belongs to the nudix hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 431.0
TLS2_k127_4696277_10 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.00000003409 63.0
TLS2_k127_4696277_2 glycosylase i K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 304.0
TLS2_k127_4696277_3 Metal dependent phosphohydrolases with conserved 'HD' motif. K06952 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000118 267.0
TLS2_k127_4696277_4 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008507 274.0
TLS2_k127_4696277_5 Belongs to the GcvT family K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003167 265.0
TLS2_k127_4696277_6 ABC transporter K02003,K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000004352 230.0
TLS2_k127_4696277_7 protein tyrosine phosphatase - - - 0.00000000000000000000000000000000000000000000000001548 186.0
TLS2_k127_4696277_8 Dehydrogenase K21430 - - 0.0000000000000000000000000001428 118.0
TLS2_k127_4696277_9 Uncharacterized protein conserved in bacteria (DUF2188) - - - 0.00000000000000007318 83.0
TLS2_k127_4710568_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 GO:0008150,GO:0008152,GO:0055114 1.6.1.2 1.72e-214 672.0
TLS2_k127_4710568_1 Alpha/beta hydrolase family K06889 - - 0.000000000000000000000000000000000000000000000000000000000000009958 225.0
TLS2_k127_4710568_2 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000339 220.0
TLS2_k127_4710568_3 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.0000000000000000000000000000009116 124.0
TLS2_k127_4712331_0 depolymerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003556 265.0
TLS2_k127_4712331_1 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000998 249.0
TLS2_k127_4712331_2 acetyltransferase - - - 0.00000000000000000000000000002418 122.0
TLS2_k127_471411_0 unusual protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 439.0
TLS2_k127_471411_1 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. K13449,K20412 - - 0.000000000000000001945 94.0
TLS2_k127_4719640_0 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 297.0
TLS2_k127_4719640_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000000000000000000000003344 204.0
TLS2_k127_4719640_2 Glycosyl hydrolase family 3 N terminal domain K01207,K05349 - 3.2.1.21,3.2.1.52 0.0000000000000000000000000000000008997 134.0
TLS2_k127_4722884_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 587.0
TLS2_k127_4722884_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 417.0
TLS2_k127_4722884_2 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002512 273.0
TLS2_k127_4722884_3 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000009075 228.0
TLS2_k127_4722884_4 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000521 213.0
TLS2_k127_4722884_5 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000003744 207.0
TLS2_k127_4722884_6 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000005672 142.0
TLS2_k127_4740739_0 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001403 233.0
TLS2_k127_4740739_1 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000002057 203.0
TLS2_k127_4740739_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000001141 169.0
TLS2_k127_4741177_0 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000004877 203.0
TLS2_k127_4749665_0 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 9.963e-224 700.0
TLS2_k127_4749665_1 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 418.0
TLS2_k127_4749665_2 Aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 385.0
TLS2_k127_4749665_3 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000001152 227.0
TLS2_k127_4749665_4 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000003165 212.0
TLS2_k127_4749665_5 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000007933 220.0
TLS2_k127_4749665_6 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - 0.0000000000000000000000000000000000000000000000005325 180.0
TLS2_k127_475826_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 407.0
TLS2_k127_475826_1 membrane K08973 - - 0.0000000000000000000000000000000000000000000000000006909 186.0
TLS2_k127_475826_2 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000006105 145.0
TLS2_k127_4762797_0 glutamine synthetase K01915 - 6.3.1.2 2.301e-233 731.0
TLS2_k127_4762797_1 Belongs to the P(II) protein family K04751 GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772 - 0.00000000000000000000000000000000000000000000000000000000004093 206.0
TLS2_k127_4777271_0 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003173 307.0
TLS2_k127_4777271_1 Protein of unknown function (DUF3175) - - - 0.00000000000000000000000000000483 123.0
TLS2_k127_4777271_2 - - - - 0.0000000000000000000000000004128 120.0
TLS2_k127_4779073_0 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 361.0
TLS2_k127_4779073_1 Domain of unknown function (DUF4131) K02238 - - 0.0000000000000000000000000000000000000000000000001588 186.0
TLS2_k127_4779073_2 Competence protein K02238 - - 0.000000000000000000000001059 115.0
TLS2_k127_4783457_0 Elongation factor G C-terminus K06207 GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 0.00000000000000000000000000000000000000000000000000001404 189.0
TLS2_k127_4783457_1 FR47-like protein - - - 0.00000000000000000000000000000000000000000000000000008002 192.0
TLS2_k127_4794369_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 4.335e-236 736.0
TLS2_k127_4794369_1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000072 56.0
TLS2_k127_4811549_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 3.409e-249 777.0
TLS2_k127_4811549_1 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000004084 232.0
TLS2_k127_4815288_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1213.0
TLS2_k127_4815288_1 ClpX C4-type zinc finger K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 9.253e-238 738.0
TLS2_k127_4815288_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005858 333.0
TLS2_k127_4815288_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 298.0
TLS2_k127_4815288_4 Thioesterase K18700 - 3.1.2.29 0.00000000000000000000000000000000000000000000000000001748 193.0
TLS2_k127_4815288_5 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000003212 109.0
TLS2_k127_4815288_7 Caspase domain - - - 0.0000001305 62.0
TLS2_k127_4815288_8 - - - - 0.00004342 47.0
TLS2_k127_4820524_0 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 1.204e-257 808.0
TLS2_k127_4820524_1 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004334 572.0
TLS2_k127_4820524_2 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 321.0
TLS2_k127_4820524_3 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000011 200.0
TLS2_k127_4820524_4 Protein conserved in bacteria K09937 - - 0.0000000000001855 71.0
TLS2_k127_4833680_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - 1.945e-226 713.0
TLS2_k127_4833680_1 ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000000000000000000000000001704 188.0
TLS2_k127_4845139_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.252e-243 760.0
TLS2_k127_4845139_1 ATP dependent DNA ligase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 294.0
TLS2_k127_4845139_2 ATP dependent DNA ligase domain - - - 0.000000000000000445 89.0
TLS2_k127_4848288_0 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006237 345.0
TLS2_k127_4848288_1 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001345 275.0
TLS2_k127_4848288_2 Disulfide bond formation protein DsbB K03611 - - 0.00000000000000000000000000000000000004003 151.0
TLS2_k127_4848288_3 PFAM aldo keto reductase - - - 0.00000000000000003831 84.0
TLS2_k127_4856274_0 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 404.0
TLS2_k127_4870532_0 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003960,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016651,GO:0016655,GO:0017091,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:1901363 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 464.0
TLS2_k127_4870532_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 293.0
TLS2_k127_4870584_0 MltA specific insert domain K08304 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000749 326.0
TLS2_k127_4870584_1 PFAM Smr protein MutS2 - - - 0.0000000000000000000000000000001183 131.0
TLS2_k127_4870692_0 Zincin-like metallopeptidase K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000008618 187.0
TLS2_k127_4870692_1 - - - - 0.000000000000000000002222 102.0
TLS2_k127_4870692_2 - - - - 0.000000000153 69.0
TLS2_k127_4892905_0 Glycosyl transferase family 21 K00694,K01210 - 2.4.1.12,3.2.1.58 9.35e-321 1005.0
TLS2_k127_4892905_1 beta (1-6) glucans synthase K01210 - 3.2.1.58 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 446.0
TLS2_k127_4892905_2 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 372.0
TLS2_k127_4892905_3 Activator of Hsp90 ATPase - - - 0.000000000000000000000000000000000000000000000000000000001577 205.0
TLS2_k127_4892905_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000227 164.0
TLS2_k127_4892905_5 - - - - 0.000000000000000000000000000000000003714 143.0
TLS2_k127_4892905_6 Adenylate cyclase - - - 0.0000000000000000000001035 103.0
TLS2_k127_489474_0 Putative S-adenosyl-L-methionine-dependent methyltransferase K00574,K18164 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 354.0
TLS2_k127_489474_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 330.0
TLS2_k127_489474_2 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 291.0
TLS2_k127_489474_3 - - - - 0.00000000000000000000000000000000000000000000000000000001647 212.0
TLS2_k127_489474_4 Membrane fusogenic activity K09806 - - 0.00000000000000000000001219 115.0
TLS2_k127_489474_5 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000001672 101.0
TLS2_k127_4904415_0 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 407.0
TLS2_k127_4904415_1 Peptidase S24-like - - - 0.000000000000000000000000000000000000000738 162.0
TLS2_k127_4904415_2 arsenate reductase K00537 - 1.20.4.1 0.000000000000000000000000000000000000001004 161.0
TLS2_k127_4904415_3 Protein of unknown function (DUF952) - - - 0.0000000000000000000000000000000006979 133.0
TLS2_k127_4904415_4 repressor - - - 0.000000000000000000000000000003482 128.0
TLS2_k127_4904415_5 - - - - 0.0000000000000000000001276 100.0
TLS2_k127_4904415_6 nuclease - - - 0.0000000324 64.0
TLS2_k127_4906006_0 ErfK YbiS YcfS YnhG family protein K21470,K21572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 350.0
TLS2_k127_4906006_1 pfam nudix - - - 0.0000000000000000000000000000000000000000000000000000000004471 206.0
TLS2_k127_4906006_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000005263 188.0
TLS2_k127_4906006_3 COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000008562 192.0
TLS2_k127_4906006_4 Cell Wall - - - 0.00000000000000000000000000000000000000000005073 169.0
TLS2_k127_4906006_5 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0000000000004592 72.0
TLS2_k127_4912611_0 Carbon-nitrogen hydrolase K11206 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 337.0
TLS2_k127_4912611_1 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 293.0
TLS2_k127_4912611_2 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002631 288.0
TLS2_k127_4912611_3 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000006323 149.0
TLS2_k127_4912611_4 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.00000000000000000000000000004068 119.0
TLS2_k127_4913250_0 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 476.0
TLS2_k127_4913250_1 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935,K02169 - 2.1.1.197,6.3.3.3 0.000000000000000000000000000000000000000000000000000000000111 211.0
TLS2_k127_4913250_2 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935,K02169 - 2.1.1.197,6.3.3.3 0.0000000000000000000000000000000000000000004563 167.0
TLS2_k127_4913250_3 carboxylic ester hydrolase activity K02170 - 3.1.1.85 0.0000000000000000000000000000000006213 138.0
TLS2_k127_4913250_4 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.0000000000000000000000003741 108.0
TLS2_k127_4957432_0 Protein of unknown function (DUF3365) K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006331 363.0
TLS2_k127_4957432_1 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000005266 246.0
TLS2_k127_4957432_2 Stage II sporulation protein E (SpoIIE) - - - 0.000000000000000000000000000000000000000000000000000000003478 228.0
TLS2_k127_4957432_3 - - - - 0.000000000000000000000000000000000000000000000001441 179.0
TLS2_k127_4957432_4 Domain of unknown function (DUF1987) - - - 0.000000000000000000000000000000001319 137.0
TLS2_k127_4958911_0 hydrolase of the metallo-beta-lactamase superfamily K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001566 276.0
TLS2_k127_4958911_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000005146 229.0
TLS2_k127_4958911_2 Protein of unknown function (DUF1467) - - - 0.00000000000000001143 85.0
TLS2_k127_4959659_0 NADH-ubiquinone oxidoreductase chain 49kDa - - - 1.454e-205 649.0
TLS2_k127_4959659_1 Proton-conducting membrane transporter K12141 - - 8.482e-198 624.0
TLS2_k127_4969847_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 579.0
TLS2_k127_4969847_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 483.0
TLS2_k127_4969847_2 Haem-degrading - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001111 250.0
TLS2_k127_4969847_3 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000358 246.0
TLS2_k127_4969847_4 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000005894 243.0
TLS2_k127_4969847_5 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000000000000000000005926 216.0
TLS2_k127_4969847_6 methyl-accepting chemotaxis protein K03406 - - 0.000000000000000000000000000000000000000000000001193 180.0
TLS2_k127_4969847_7 Dodecin K09165 - - 0.000000000000000000003162 95.0
TLS2_k127_4976194_0 NADH-ubiquinone oxidoreductase subunit G, C-terminal K00336 - 1.6.5.3 7.113e-315 981.0
TLS2_k127_4976194_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008245 518.0
TLS2_k127_4976194_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 468.0
TLS2_k127_4976194_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K03941 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3,1.6.99.3 0.000000000000000000000000001096 113.0
TLS2_k127_4976194_4 - - - - 0.000007889 54.0
TLS2_k127_4977811_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.0 1050.0
TLS2_k127_4977811_1 Belongs to the beta-ketoacyl-ACP synthases family K00647 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.41 2.891e-207 649.0
TLS2_k127_4977811_10 Bacterial-like globin K06886 - - 0.00000000000000000000000000001285 122.0
TLS2_k127_4977811_11 Bacterial SH3 domain homologues K01876 - 6.1.1.12 0.00000000000000000000000000002312 119.0
TLS2_k127_4977811_12 - - - - 0.00006493 48.0
TLS2_k127_4977811_2 Enoyl- acyl-carrier-protein reductase NADH K00208 GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 429.0
TLS2_k127_4977811_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006225 371.0
TLS2_k127_4977811_4 Translation-initiation factor 2 K02519 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 348.0
TLS2_k127_4977811_5 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length K01716 - 4.2.1.59,5.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 309.0
TLS2_k127_4977811_6 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005727 258.0
TLS2_k127_4977811_7 Belongs to the Fur family K09826 - - 0.0000000000000000000000000000000000000000000000003996 181.0
TLS2_k127_4977811_8 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000000000000002381 158.0
TLS2_k127_4977811_9 Ribosomal_S15 K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000001946 149.0
TLS2_k127_4986409_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 9.84e-275 853.0
TLS2_k127_4986409_1 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006006 268.0
TLS2_k127_4986409_2 PFAM GYD family protein - - - 0.000000000000000000000000008755 113.0
TLS2_k127_4991262_0 MoeA N-terminal region (domain I and II) K03750 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0042802,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 400.0
TLS2_k127_4991262_1 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000006326 128.0
TLS2_k127_4991262_2 LexA DNA binding domain K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.0000000008812 59.0
TLS2_k127_49972_0 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004816 251.0
TLS2_k127_49972_1 Putative transmembrane protein (Alph_Pro_TM) - - - 0.000000000000000000000000000000000000000000000000002336 198.0
TLS2_k127_49972_2 Calcineurin-like phosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000001071 175.0
TLS2_k127_5019013_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 595.0
TLS2_k127_5022500_0 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005366 269.0
TLS2_k127_5022500_1 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001405 256.0
TLS2_k127_5022500_2 - - - - 0.000000000000000000000000000000000000000000000004156 176.0
TLS2_k127_5022500_3 Sulfatase-modifying factor enzyme 1 - - - 0.000000000804 61.0
TLS2_k127_5028384_0 Formate dehydrogenase subunit alpha - - - 0.0 1109.0
TLS2_k127_5028384_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00122 - 1.17.1.9 1.163e-232 737.0
TLS2_k127_5028384_2 COG4662 ABC-type tungstate transport system, periplasmic component K05773 - - 0.0000000000000000000000000002801 123.0
TLS2_k127_5050573_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 2.298e-221 692.0
TLS2_k127_5050573_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000001342 239.0
TLS2_k127_5050573_2 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000008114 187.0
TLS2_k127_5050573_3 Domain of unknown function (DUF1476) - - - 0.0000000000000000000000000000000000001032 143.0
TLS2_k127_5050573_4 - - - - 0.00000000000001774 87.0
TLS2_k127_5052444_0 Lipoprotein releasing system transmembrane protein K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 545.0
TLS2_k127_5052444_1 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006807,GO:0006810,GO:0008104,GO:0008150,GO:0008152,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022804,GO:0022857,GO:0031224,GO:0032991,GO:0033036,GO:0042157,GO:0042160,GO:0042623,GO:0042626,GO:0042886,GO:0042953,GO:0043170,GO:0043190,GO:0043492,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901564,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 295.0
TLS2_k127_5052444_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 0.0000000000000000000000000000000000000000000000000000002789 196.0
TLS2_k127_5052444_3 DNA polymerase K02337 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.000000000000000000000000000000000000000000000000000002123 197.0
TLS2_k127_5064273_0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 4.688e-264 824.0
TLS2_k127_5064273_1 May be involved in the biosynthesis of molybdopterin K03638 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 2.7.7.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004412 271.0
TLS2_k127_5064273_2 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000006408 265.0
TLS2_k127_5064273_3 Diguanylate cyclase, GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000593 239.0
TLS2_k127_5064273_4 Zinc-dependent metalloprotease - - - 0.00001349 57.0
TLS2_k127_5069296_0 Cell division protein K09811 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 344.0
TLS2_k127_5069296_1 cell division ATP-binding protein FtsE K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007412 310.0
TLS2_k127_5069296_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 314.0
TLS2_k127_5069296_3 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000001012 184.0
TLS2_k127_508313_0 Erythromycin esterase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 484.0
TLS2_k127_508313_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009515 360.0
TLS2_k127_508313_2 COG1136 ABC-type antimicrobial peptide transport system ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003931 287.0
TLS2_k127_5109919_0 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 574.0
TLS2_k127_5109919_1 Histidine-specific methyltransferase, SAM-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 336.0
TLS2_k127_5109919_2 Phosphodiester glycosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001588 266.0
TLS2_k127_5125628_0 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 471.0
TLS2_k127_5125628_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004249 441.0
TLS2_k127_5125628_2 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000008787 203.0
TLS2_k127_5125628_3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.00000000000000000000000000001094 119.0
TLS2_k127_512714_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 508.0
TLS2_k127_512714_1 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009678 471.0
TLS2_k127_512714_2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 375.0
TLS2_k127_512714_3 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000006671 241.0
TLS2_k127_512714_4 Penicillin binding protein transpeptidase domain K17838,K19211,K21277 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000001445 238.0
TLS2_k127_512714_5 LppC putative lipoprotein - - - 0.00000000000000000000000000000000000000000000000002128 183.0
TLS2_k127_5148307_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 355.0
TLS2_k127_5148307_1 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000000000005355 109.0
TLS2_k127_5180072_0 Zn-dependent metallo-hydrolase RNA specificity domain K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 462.0
TLS2_k127_5180072_1 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000001431 166.0
TLS2_k127_5180383_0 Glycosyl hydrolases family 15 - - - 9.327e-242 759.0
TLS2_k127_5180383_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 336.0
TLS2_k127_5180383_2 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000008325 239.0
TLS2_k127_5180383_3 (twin-arginine translocation) pathway signal - - - 0.0000000000000000000000000000000000000000000000000000000000000008106 225.0
TLS2_k127_5180383_4 von Willebrand factor, type A - - - 0.0000000000000000000000000000000000000000000000000000005998 201.0
TLS2_k127_5180383_5 Rhomboid family - - - 0.000000000000000001351 86.0
TLS2_k127_5233184_0 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003229 551.0
TLS2_k127_5233184_1 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 - 3.5.4.13 0.0000000000000000000000000000255 122.0
TLS2_k127_5233184_2 Uncharacterized conserved protein (DUF2277) - - - 0.000000000000000000008616 96.0
TLS2_k127_5286841_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 1.5e-323 995.0
TLS2_k127_5286841_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 419.0
TLS2_k127_5377756_0 - - - - 0.00000000000000000000000000000000000002287 154.0
TLS2_k127_5377756_1 Sugar-transfer associated ATP-grasp - - - 0.00000000000000000000000000009614 124.0
TLS2_k127_5377756_2 integral membrane protein - - - 0.00001851 55.0
TLS2_k127_5411820_0 SurA N-terminal domain K01802,K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 310.0
TLS2_k127_5411820_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.0000000000000000000000008198 112.0
TLS2_k127_5421523_0 Rod shape-determining protein (MreB) K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 376.0
TLS2_k127_5421523_1 shape-determining protein MreC K03570 - - 0.0000000000000000000000000000000000000000000000000000002346 209.0
TLS2_k127_544181_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.8.1.4 4.114e-222 696.0
TLS2_k127_544181_1 - - - - 0.000000000000000000000000000343 119.0
TLS2_k127_544181_2 - - - - 0.0000003187 61.0
TLS2_k127_5502834_0 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family K03185 GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002941 407.0
TLS2_k127_5502834_1 tRNA synthetases class I (E and Q), catalytic domain K01894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 367.0
TLS2_k127_5502834_2 peptidase S16 K01338,K07157 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000002775 249.0
TLS2_k127_5502834_3 Trm112p-like protein K09791 - - 0.00000000000000000000002309 104.0
TLS2_k127_5613876_0 HAMP domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009003 436.0
TLS2_k127_5613876_1 Transcriptional regulatory protein, C terminal K02483,K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 351.0
TLS2_k127_5613876_2 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 318.0
TLS2_k127_5613876_3 polygalacturonase activity - - - 0.000000000000000000000000000000000000000000000000000000000003345 221.0
TLS2_k127_5613876_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000006802 151.0
TLS2_k127_5613876_5 Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 0.000000000000000000000000000000000804 137.0
TLS2_k127_5613876_6 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000187 101.0
TLS2_k127_5613876_7 - - - - 0.0000000000005062 70.0
TLS2_k127_5614226_0 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 517.0
TLS2_k127_5614226_1 Alkylated DNA repair protein K03919 - 1.14.11.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 293.0
TLS2_k127_5614226_2 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000001505 167.0
TLS2_k127_5617107_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 367.0
TLS2_k127_5617107_1 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000339 232.0
TLS2_k127_5617107_2 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000000001551 135.0
TLS2_k127_5621810_0 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 426.0
TLS2_k127_5621810_1 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000003112 250.0
TLS2_k127_5621810_2 Carboxylesterase family K01066 - - 0.00000000000000000000000000000000000000000000000000000000000000001056 239.0
TLS2_k127_5621810_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000009072 224.0
TLS2_k127_5621810_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000001624 219.0
TLS2_k127_5621810_5 - - - - 0.0000000000000000000193 93.0
TLS2_k127_5621810_6 receptor K02014 - - 0.0002488 47.0
TLS2_k127_5623331_0 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 477.0
TLS2_k127_5623331_1 prohibitin homologues - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007598 428.0
TLS2_k127_5623331_2 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009332 344.0
TLS2_k127_5623331_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003823 273.0
TLS2_k127_5623331_4 NfeD-like C-terminal, partner-binding K07340 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000342 139.0
TLS2_k127_5623331_5 - - - - 0.000000000001781 79.0
TLS2_k127_5625201_0 PFAM Carbohydrate-selective porin OprB K07267 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 348.0
TLS2_k127_5625201_1 Imelysin K07231 - - 0.0000000000000000000000000000000000000000000000000000002838 197.0
TLS2_k127_5625201_2 Imelysin K07231 - - 0.00000000136 59.0
TLS2_k127_5628247_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007923 373.0
TLS2_k127_5628247_1 Thioredoxin-like [2Fe-2S] ferredoxin K00334,K03943 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 307.0
TLS2_k127_5628247_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000002149 78.0
TLS2_k127_5642015_0 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 476.0
TLS2_k127_5642015_1 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 447.0
TLS2_k127_5642015_2 RNase H K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000006131 242.0
TLS2_k127_5642015_3 Redoxin K03386 - 1.11.1.15 0.00000000000000000000001549 100.0
TLS2_k127_5646666_0 PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein K01738,K01740 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47,2.5.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 340.0
TLS2_k127_5646666_1 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 329.0
TLS2_k127_5646666_2 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000006545 241.0
TLS2_k127_5646666_3 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000001578 232.0
TLS2_k127_5646666_4 CoA binding domain K06929 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000002618 224.0
TLS2_k127_5646666_5 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000003475 116.0
TLS2_k127_5660327_0 membrane - - - 4.795e-244 771.0
TLS2_k127_5660327_1 Domain of unknown function (DUF4159) - - - 7.491e-238 755.0
TLS2_k127_5666014_0 LysR substrate binding domain K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 327.0
TLS2_k127_5666014_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.000000000000000000000000000000000000000000000000000000000000009845 235.0
TLS2_k127_5674699_0 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007893 478.0
TLS2_k127_5674699_1 Transcriptional - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 300.0
TLS2_k127_5685296_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K02337,K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009683 419.0
TLS2_k127_5685296_1 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 377.0
TLS2_k127_5685296_2 SOS response K14160 - - 0.0000000000000001078 91.0
TLS2_k127_5685296_3 Flp Fap pilin component K02651 - - 0.0000000000000005877 80.0
TLS2_k127_5704091_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 563.0
TLS2_k127_5704091_1 CHASE3 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009139 308.0
TLS2_k127_5704091_2 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002066 271.0
TLS2_k127_5704091_3 cheY-homologous receiver domain - - - 0.000000000000000000000000000000008655 131.0
TLS2_k127_5721000_0 Major facilitator superfamily - - - 3.272e-267 833.0
TLS2_k127_5721000_1 Catalyzes the NAD( )-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non- methylotrophic organisms - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 355.0
TLS2_k127_5721000_2 Cation efflux family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002976 264.0
TLS2_k127_5731316_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 1.881e-211 680.0
TLS2_k127_5731316_1 Sulfate transporter K03321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 308.0
TLS2_k127_5731316_2 Protein of unknown function (DUF3307) - - - 0.0000000000000000000000000000000003951 138.0
TLS2_k127_5739775_0 ErfK YbiS YcfS YnhG family protein K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 417.0
TLS2_k127_5739775_1 - - - - 0.000000000000000000000000000000000000000001394 165.0
TLS2_k127_5739775_2 molecular chaperone - - - 0.00000000000000000000001239 111.0
TLS2_k127_5743767_0 PFAM Amylo-alpha-16-glucosidase - - - 9.443e-204 659.0
TLS2_k127_5743767_1 Glycosyl transferases group 1 K12995 - 2.4.1.348 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004359 432.0
TLS2_k127_5743767_2 Beta-lactamase - - - 0.000000000000000000000000000000007266 132.0
TLS2_k127_5743767_3 Beta-lactamase - - - 0.000000000000000000666 87.0
TLS2_k127_5746369_0 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 311.0
TLS2_k127_5746369_1 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000003556 183.0
TLS2_k127_5751706_0 cobalt chelatase K09883 - 6.6.1.2 7.348e-233 743.0
TLS2_k127_5751706_1 Cobaltochelatase CobS subunit N terminal K09882 - 6.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007858 312.0
TLS2_k127_5755644_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004557 454.0
TLS2_k127_5755644_1 - - - - 0.000000000000000000000000000000000000001892 155.0
TLS2_k127_5755644_2 Phasin protein - - - 0.0000000000000000000000000000001179 130.0
TLS2_k127_5755644_3 helix_turn_helix ASNC type - GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009889,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000123 94.0
TLS2_k127_5755965_0 ATPase AAA K03924 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007226 503.0
TLS2_k127_5755965_1 Protein of unknown function (DUF1285) K09986 - - 0.00000000000000000000000000000000000000000000003627 177.0
TLS2_k127_5755965_2 Protein of unknown function DUF58 - - - 0.000000000000000000000000006229 114.0
TLS2_k127_5766073_0 Belongs to the GPI family K01810,K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003842 534.0
TLS2_k127_5766073_1 Belongs to the peptidase M16 family K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 530.0
TLS2_k127_5766073_2 Peptidase M16 inactive domain K07263,K07623 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 472.0
TLS2_k127_5766073_3 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004864 400.0
TLS2_k127_5766602_0 Putative diguanylate phosphodiesterase K13245 - 3.1.4.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 516.0
TLS2_k127_5766602_1 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000001054 127.0
TLS2_k127_5773767_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005868 602.0
TLS2_k127_5773767_1 EF hand - - - 0.0000000000000001667 91.0
TLS2_k127_5773767_2 Ceramidase - - - 0.0000007305 54.0
TLS2_k127_5795732_0 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004978 312.0
TLS2_k127_5795732_1 ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 309.0
TLS2_k127_5795732_2 PFAM Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000000000000000000000000000000000000000003082 219.0
TLS2_k127_5795732_3 Belongs to the ompA family K03286 - - 0.00000000000000000000000000000000003495 149.0
TLS2_k127_5795732_4 Protein of unknown function (DUF3096) - - - 0.000000005254 61.0
TLS2_k127_5800617_0 alanine symporter K03310 - - 2.949e-206 649.0
TLS2_k127_5800617_1 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 358.0
TLS2_k127_5800617_2 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 331.0
TLS2_k127_5800617_3 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000003446 171.0
TLS2_k127_5800617_5 Sulfotransferase domain - - - 0.00000000000000000000001158 102.0
TLS2_k127_5801602_0 CYTH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 329.0
TLS2_k127_5801602_1 CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000004723 237.0
TLS2_k127_5801602_2 Amidase K01457 - 3.5.1.54 0.0000000000000000000000000000000000000000000000000000003086 196.0
TLS2_k127_5801602_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000005419 169.0
TLS2_k127_5801602_4 PFAM Cold-shock protein, DNA-binding - - - 0.0000000000000000000000000000000000000000004439 162.0
TLS2_k127_5801602_5 sporulation resulting in formation of a cellular spore K01449 - 3.5.1.28 0.000000000000000000000000000000009275 136.0
TLS2_k127_5801602_6 GGDEF domain - - - 0.00000000000000000000000000000004526 142.0
TLS2_k127_5801602_7 diguanylate cyclase - - - 0.000004835 58.0
TLS2_k127_5801602_8 Bacterial protein of unknown function (DUF883) - - - 0.000006504 51.0
TLS2_k127_5817425_0 poly(R)-hydroxyalkanoic acid synthase K03821 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 5.584e-264 826.0
TLS2_k127_5817425_1 Aminotransferase K14261 GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 608.0
TLS2_k127_5817425_2 Putative zinc-binding metallo-peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005372 332.0
TLS2_k127_5821810_0 FAD linked oxidases, C-terminal domain K00102 GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617 1.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 526.0
TLS2_k127_5821810_1 PFAM Histone deacetylase domain K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 404.0
TLS2_k127_5821810_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 353.0
TLS2_k127_5821810_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000102 49.0
TLS2_k127_5833216_0 Transposase - - - 9.081e-224 700.0
TLS2_k127_5843384_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003454 548.0
TLS2_k127_5843384_1 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 495.0
TLS2_k127_5843384_2 PQQ-like domain K17713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 447.0
TLS2_k127_5843384_3 PFAM Adenosine AMP deaminase K01488 - 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005647 312.0
TLS2_k127_5843384_4 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000003839 213.0
TLS2_k127_5843384_5 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000005907 205.0
TLS2_k127_5843384_6 DNA polymerase III chi subunit, HolC K02339 - 2.7.7.7 0.00000000000000000000000000000000000000000000000008797 193.0
TLS2_k127_5843384_7 Tetratricopeptide repeat-like domain - - - 0.0000001604 54.0
TLS2_k127_584561_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 1.064e-204 646.0
TLS2_k127_584561_1 Peptidase C26 K01658,K01664 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000001102 172.0
TLS2_k127_584561_2 phosphohistidine phosphatase, SixA K08296 - - 0.0000000000000000000000000000000000000004635 156.0
TLS2_k127_5847637_0 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 514.0
TLS2_k127_5847637_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 454.0
TLS2_k127_5847637_2 Transcriptional regulator K02483 GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004623 371.0
TLS2_k127_5847637_3 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 378.0
TLS2_k127_5847637_4 Cytochrome c-type biogenesis protein K02198 - - 0.0000000000000000000000000000000000000000000000000000000004935 205.0
TLS2_k127_5847637_5 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000000000000004127 174.0
TLS2_k127_5850484_0 E1 component K00164 - 1.2.4.2 1.685e-301 931.0
TLS2_k127_5850484_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000003735 93.0
TLS2_k127_5858820_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007604 569.0
TLS2_k127_5858820_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 528.0
TLS2_k127_5858820_2 Quinolinate phosphoribosyl transferase, C-terminal domain K00767,K03813 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 323.0
TLS2_k127_5858820_3 ErfK YbiS YcfS YnhG family protein K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007516 325.0
TLS2_k127_5858820_4 Cell wall hydrolyses involved in spore germination - - - 0.0000000000000001028 84.0
TLS2_k127_5858820_5 - - - - 0.000000007847 58.0
TLS2_k127_5868858_0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008671 488.0
TLS2_k127_5868858_1 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007545 271.0
TLS2_k127_5868858_2 Disulfide bond formation protein DsbB - - - 0.0000000000000000000000000000000000000000000000000000000029 205.0
TLS2_k127_5868858_3 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000002475 198.0
TLS2_k127_5875899_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 567.0
TLS2_k127_5875899_1 Beta-lactamase superfamily domain K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007126 362.0
TLS2_k127_5875899_2 Hydrolase, TatD family K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 329.0
TLS2_k127_5875899_3 KR domain - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001557 271.0
TLS2_k127_5875899_4 Outer membrane autotransporter - - - 0.0000005435 59.0
TLS2_k127_5900927_0 ErfK YbiS YcfS YnhG family protein K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 415.0
TLS2_k127_5900927_1 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004921 273.0
TLS2_k127_5900927_2 Sigma-54 interaction domain - GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000008154 237.0
TLS2_k127_5900927_3 MgtC family K07507 - - 0.0000000000000000000000000000000000000000000000773 173.0
TLS2_k127_5900927_4 Protein conserved in bacteria K09948 - - 0.00000000000000000000000000000000006014 140.0
TLS2_k127_5900927_5 Belongs to the UPF0335 family - - - 0.0000000000000000000000001871 109.0
TLS2_k127_5911133_1 AntiSigma factor - - - 0.0000000000000000007127 98.0
TLS2_k127_5911133_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000001515 78.0
TLS2_k127_5911133_3 protein containing double-stranded beta helix domain - - - 0.00000002506 61.0
TLS2_k127_5916676_0 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004704 357.0
TLS2_k127_5916676_1 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005811 360.0
TLS2_k127_5916676_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 324.0
TLS2_k127_5927867_0 GntP family permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007387 553.0
TLS2_k127_5927867_1 Glutaminase K01425 - 3.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 440.0
TLS2_k127_5927867_10 - - - - 0.0000002501 62.0
TLS2_k127_5927867_2 glutamine synthetase K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 402.0
TLS2_k127_5927867_3 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 318.0
TLS2_k127_5927867_4 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 291.0
TLS2_k127_5927867_5 PFAM Metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003126 273.0
TLS2_k127_5927867_6 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008376 252.0
TLS2_k127_5927867_7 amino acid - - - 0.0000000000000000000000000000000000000000000000000006344 206.0
TLS2_k127_5927867_8 - - - - 0.00000000000000000000000000000000000000000002175 172.0
TLS2_k127_5927867_9 PFAM regulatory protein, MerR - - - 0.000000002587 68.0
TLS2_k127_5955433_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K13598 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 7.732e-232 741.0
TLS2_k127_5955433_1 Sigma-54 interaction domain K13599 - - 0.000000000000000000000000000000000000000000000000000003432 191.0
TLS2_k127_5960926_0 Transposase DDE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 493.0
TLS2_k127_6009728_0 AsmA-like C-terminal region K07289 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002509 290.0
TLS2_k127_6009728_1 Sodium:sulfate symporter transmembrane region - - - 0.00000000000000000000000000000003394 126.0
TLS2_k127_6009728_2 - - - - 0.0001663 49.0
TLS2_k127_603296_0 Belongs to the GcvT family K19191 GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.5.3.19 0.0 1415.0
TLS2_k127_603296_1 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000605 409.0
TLS2_k127_603296_2 Choline kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000044 351.0
TLS2_k127_603296_3 integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000005808 196.0
TLS2_k127_603296_4 Alpha/beta hydrolase family K06889 - - 0.0000000000000000000000000000000000000000000000001587 190.0
TLS2_k127_60697_0 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 565.0
TLS2_k127_60697_1 transport system, fused permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 386.0
TLS2_k127_60697_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000000000000000000000000000000000000000000000002384 199.0
TLS2_k127_60697_3 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000004237 132.0
TLS2_k127_60697_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.000009161 49.0
TLS2_k127_6071288_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007719 528.0
TLS2_k127_6071288_1 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.00000000000000000000001664 103.0
TLS2_k127_60818_0 His Kinase A (phosphoacceptor) domain K13587 - 2.7.13.3 6.291e-274 867.0
TLS2_k127_60818_1 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009191 275.0
TLS2_k127_60818_2 Flagellar biosynthesis protein, FliO - - - 0.0000000000008865 73.0
TLS2_k127_6086976_0 DegT/DnrJ/EryC1/StrS aminotransferase family K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 516.0
TLS2_k127_6086976_1 Domain of unknown function (DUF892) - - - 0.00000000000000000000000000000000000000000000000000000000003346 212.0
TLS2_k127_6086976_2 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000000000000000000000000000000000000000000115 165.0
TLS2_k127_6086976_3 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000000000000000000000000000000000002948 157.0
TLS2_k127_6086976_4 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000001048 161.0
TLS2_k127_6086976_5 Protein of unknown function (DUF3775) - - - 0.000000000000009219 80.0
TLS2_k127_6086976_6 - - - - 0.00001442 49.0
TLS2_k127_6091155_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 344.0
TLS2_k127_6091155_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 340.0
TLS2_k127_6091155_2 Isochorismatase hydrolase - - - 0.000000000000000000000000000000000000000000000471 172.0
TLS2_k127_6091155_3 of ABC transporters with duplicated ATPase K06158 - - 0.000000000000000000000000000000000000000000002232 170.0
TLS2_k127_6099975_0 DDE superfamily endonuclease - - - 9.467e-194 614.0
TLS2_k127_6099975_1 Winged helix-turn helix - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 305.0
TLS2_k127_6150806_0 ferredoxin--NADP reductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000482 199.0
TLS2_k127_6150806_1 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - 0.0000000000000000000000005546 118.0
TLS2_k127_6176850_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 2.233e-213 668.0
TLS2_k127_6176850_1 Ion transport protein K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 358.0
TLS2_k127_6176850_2 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002135 276.0
TLS2_k127_6176850_3 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.000000000000000000000008439 103.0
TLS2_k127_6187171_0 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 366.0
TLS2_k127_6187171_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 302.0
TLS2_k127_6187171_2 MerR HTH family regulatory protein K18997 - - 0.0000000000000000000000004553 111.0
TLS2_k127_6187171_3 DnaJ C terminal domain - - - 0.000000000000000000008221 93.0
TLS2_k127_6187171_4 Protein of unknown function (DUF2905) - - - 0.000000000008144 71.0
TLS2_k127_6208006_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - 5.417e-207 650.0
TLS2_k127_6208006_1 Protein-tyrosine phosphatase, low molecular weight K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000006174 253.0
TLS2_k127_6208006_2 peptidyl-prolyl isomerase K01802,K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000004427 203.0
TLS2_k127_6208006_3 Helix-turn-helix domain K03892 - - 0.00000000000000000000000000000000005321 136.0
TLS2_k127_62210_0 NmrA-like family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 484.0
TLS2_k127_62210_1 Lytic murein transglycosylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000886 403.0
TLS2_k127_62210_2 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003023 267.0
TLS2_k127_62210_3 Transglycosylase SLT domain K00786,K08305 - - 0.0000000000000000000000000000001204 131.0
TLS2_k127_6246509_0 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 402.0
TLS2_k127_6246509_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000008793 91.0
TLS2_k127_626353_0 OmpW family K07275 - - 0.00000000000000000000000000000000000000000000000000000000000007339 222.0
TLS2_k127_626353_1 Crp-like helix-turn-helix domain K01420 - - 0.0000000000000000000000000000000001443 144.0
TLS2_k127_626353_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.000000000000000000000008865 102.0
TLS2_k127_6269294_0 Elongation factor G, domain IV K02355 - - 8.727e-293 911.0
TLS2_k127_6269294_1 Lytic murein transglycosylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 366.0
TLS2_k127_6269294_2 biosynthesis protein - - - 0.0000000000000000000000000000000000001807 147.0
TLS2_k127_6269294_3 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000002071 78.0
TLS2_k127_6269294_4 histidine kinase HAMP region domain protein K03406 - - 0.0000000005161 70.0
TLS2_k127_6269294_5 COG2199 FOG GGDEF domain K13069 - 2.7.7.65 0.00001378 50.0
TLS2_k127_6377750_0 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 520.0
TLS2_k127_6377750_1 two component transcriptional regulator K02483,K13584 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 439.0
TLS2_k127_6377750_10 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.0000000000000000007561 89.0
TLS2_k127_6377750_11 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000805 80.0
TLS2_k127_6377750_13 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000008084 56.0
TLS2_k127_6377750_14 Transposase - - - 0.000877 44.0
TLS2_k127_6377750_2 ubiE/COQ5 methyltransferase family K00570 - 2.1.1.17,2.1.1.71 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 297.0
TLS2_k127_6377750_3 Belongs to the UPF0234 family K09767 - - 0.000000000000000000000000000000000000000000000000000000000000000000004125 239.0
TLS2_k127_6377750_4 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000000000000000000003179 192.0
TLS2_k127_6377750_5 Protein of unknown function (DUF1153) - - - 0.00000000000000000000000000000000000000000000000552 173.0
TLS2_k127_6377750_6 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000004546 160.0
TLS2_k127_6377750_7 Flagellar FliJ protein - - - 0.0000000000000000000000000000000007559 134.0
TLS2_k127_6377750_8 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000007137 132.0
TLS2_k127_6377750_9 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.000000000000000000000171 101.0
TLS2_k127_6469889_0 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 394.0
TLS2_k127_6469889_1 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 346.0
TLS2_k127_6469889_2 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000002738 258.0
TLS2_k127_6469889_3 Domain of unknown function (DUF1732) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000008497 229.0
TLS2_k127_6549661_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 556.0
TLS2_k127_6549661_1 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000000000000000006447 226.0
TLS2_k127_6549661_2 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000001623 53.0
TLS2_k127_6553388_0 Patatin phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 514.0
TLS2_k127_6553388_1 Major Facilitator Superfamily K08224 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 493.0
TLS2_k127_6553388_2 KR domain K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009853 383.0
TLS2_k127_6553388_3 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 367.0
TLS2_k127_6553388_4 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 287.0
TLS2_k127_6553388_5 Cupin domain - - - 0.00000000000000000000000000000000000000000001445 167.0
TLS2_k127_6553388_6 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000009819 126.0
TLS2_k127_6554143_0 Cytochrome c - - - 5.459e-269 850.0
TLS2_k127_6557540_0 Major Facilitator Superfamily K08223 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 473.0
TLS2_k127_6557540_1 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 468.0
TLS2_k127_6557540_2 CDP-archaeol synthase K19664 - 2.7.7.67 0.0000000000000000000000000000000000000000000000002745 180.0
TLS2_k127_6557969_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 7.002e-309 955.0
TLS2_k127_6557969_1 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000001931 213.0
TLS2_k127_6557969_2 Ceramidase - - - 0.00000000000000000000000000000000000000000000000000008823 197.0
TLS2_k127_6565366_0 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001027 271.0
TLS2_k127_6565366_1 Protein of unknown function (DUF1499) - - - 0.000000000000000000000000000000000000000000000007241 183.0
TLS2_k127_6565366_2 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000005418 169.0
TLS2_k127_6569547_0 AcrB/AcrD/AcrF family K18138,K18307 - - 5.843e-211 668.0
TLS2_k127_6569547_1 Biotin carboxylase C-terminal domain K01965 GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681 6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 441.0
TLS2_k127_6572072_0 ester cyclase - - - 0.000000000000000000000000000008554 128.0
TLS2_k127_6572072_1 - - - - 0.0000000000000000000001647 105.0
TLS2_k127_6572072_2 - - - - 0.0000000000000000001122 93.0
TLS2_k127_6572072_3 - - - - 0.0000002101 55.0
TLS2_k127_6573497_0 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 404.0
TLS2_k127_6573497_1 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 396.0
TLS2_k127_6579970_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 6.612e-209 654.0
TLS2_k127_6579970_1 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006568 457.0
TLS2_k127_6579970_2 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000002117 204.0
TLS2_k127_6579970_3 cheY-homologous receiver domain - - - 0.00000000000000000000007959 109.0
TLS2_k127_6581330_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 5.708e-248 777.0
TLS2_k127_6581330_1 Cell Wall Hydrolase - - - 0.000000000000000000000000000000000000001345 158.0
TLS2_k127_6586965_0 COG2801 Transposase and inactivated derivatives K07497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 464.0
TLS2_k127_6586965_1 COG2963 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000002313 174.0
TLS2_k127_6586965_2 NACHT nucleoside triphosphatase K12132 - 2.7.11.1 0.00000000000267 72.0
TLS2_k127_6591644_0 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 2.078e-239 746.0
TLS2_k127_6591644_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00383 GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 517.0
TLS2_k127_6591644_2 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005121 515.0
TLS2_k127_6591644_3 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 292.0
TLS2_k127_6591644_4 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000833 299.0
TLS2_k127_6591644_5 KR domain K00038 - 1.1.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007217 274.0
TLS2_k127_6591644_6 Domain of unknown function (DUF4440) - - - 0.00000007741 57.0
TLS2_k127_6591644_7 SnoaL-like domain K01822 - 5.3.3.1 0.000003965 49.0
TLS2_k127_6594614_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008521 362.0
TLS2_k127_6594614_1 Participates in transcription elongation, termination and antitermination K02601 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 302.0
TLS2_k127_6594614_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000007236 227.0
TLS2_k127_6594614_3 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.000000000000000009085 84.0
TLS2_k127_6594614_4 - - - - 0.00000006636 55.0
TLS2_k127_6594614_5 Evidence 5 No homology to any previously reported sequences - - - 0.0000007482 53.0
TLS2_k127_6602811_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00410,K00412 - - 1.323e-196 624.0
TLS2_k127_6602811_1 Cytochrome c1 K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 287.0
TLS2_k127_6602811_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000009591 259.0
TLS2_k127_6602811_3 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.10.2.2 0.000000000000000000000000000000000000000000004274 164.0
TLS2_k127_6602811_4 protein conserved in bacteria - - - 0.000000000000000000000001372 115.0
TLS2_k127_6604397_0 Periplasmic binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008321 411.0
TLS2_k127_6604397_1 Lactonase, 7-bladed beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000423 400.0
TLS2_k127_6604397_2 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000009471 168.0
TLS2_k127_6604397_3 Copper chaperone PCu(A)C K09796 - - 0.000000000000000000000000000000000000002513 157.0
TLS2_k127_6604397_4 COG3909 Cytochrome c556 - - - 0.00000000000000000000000316 108.0
TLS2_k127_6608864_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.337e-251 785.0
TLS2_k127_6608864_1 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 432.0
TLS2_k127_6608864_2 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 394.0
TLS2_k127_6608864_3 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004416 316.0
TLS2_k127_6608864_4 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000144 277.0
TLS2_k127_6608864_5 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000004141 234.0
TLS2_k127_6608864_6 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000004278 227.0
TLS2_k127_6608864_7 Glutaredoxin - - - 0.00000008098 59.0
TLS2_k127_6620202_0 Elongator protein 3 MiaB NifB - - - 9.357e-303 938.0
TLS2_k127_6620202_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004376 402.0
TLS2_k127_6620202_10 ASCH domain - - - 0.000001335 53.0
TLS2_k127_6620202_2 COG1002 Type II restriction enzyme, methylase subunits - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007375 399.0
TLS2_k127_6620202_3 Pfam:Methyltransf_26 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001192 283.0
TLS2_k127_6620202_4 Domain of unknown function (DUF4167) - - - 0.0000000000000000000000000000000001546 138.0
TLS2_k127_6620202_5 Pfam:Methyltransf_26 - - - 0.000000000000000000000000000000005083 130.0
TLS2_k127_6620202_6 COG1002 Type II restriction enzyme, methylase subunits - - - 0.00000000000000000000000002365 117.0
TLS2_k127_6620202_7 - - - - 0.0000000000000000000000008789 107.0
TLS2_k127_6620202_8 - - - - 0.00000000000000003386 84.0
TLS2_k127_6620202_9 type II restriction enzyme, methylase - - - 0.0000004329 61.0
TLS2_k127_6629882_0 imidazoleglycerol-phosphate dehydratase K00817,K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,3.1.3.15,4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 330.0
TLS2_k127_6629882_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 327.0
TLS2_k127_6629882_2 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008454 283.0
TLS2_k127_6629882_3 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000001492 164.0
TLS2_k127_6629882_4 Protein of unknown function (DUF2628) - - - 0.00000000000000000000000007154 113.0
TLS2_k127_6632514_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 1.307e-275 854.0
TLS2_k127_6632514_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07484 - - 0.0000000000000000000000000000000000000000000000000000000000009399 211.0
TLS2_k127_6632514_2 Evidence 4 Homologs of previously reported genes of K07483 - - 0.0000000000000000000001184 104.0
TLS2_k127_6640695_0 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 498.0
TLS2_k127_6640695_1 COG0607 Rhodanese-related sulfurtransferase - - - 0.000000000000000000000000000000000000000000000002166 178.0
TLS2_k127_6640695_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000004768 133.0
TLS2_k127_6640695_3 TIR domain - - - 0.0000000000000000000000000000141 128.0
TLS2_k127_6640695_4 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000000000002487 111.0
TLS2_k127_6640695_5 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000002196 86.0
TLS2_k127_664857_0 ABC transporter transmembrane region K02021,K06147,K11085 - - 1.772e-200 642.0
TLS2_k127_664857_1 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179,K06125 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 389.0
TLS2_k127_664857_2 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 310.0
TLS2_k127_664857_3 glutamate--cysteine ligase K01919 - 6.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004758 306.0
TLS2_k127_664857_4 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009204 273.0
TLS2_k127_664857_5 Domain of unknown function (DUF374) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000304 209.0
TLS2_k127_664857_6 Domain of unknown function (DUF4170) - - - 0.0000000000000000000000000005564 116.0
TLS2_k127_6652090_0 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008436 321.0
TLS2_k127_6652090_1 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000001174 205.0
TLS2_k127_6652090_2 2OG-Fe(II) oxygenase superfamily K03919 - 1.14.11.33 0.0000000000000000006336 86.0
TLS2_k127_6653893_0 phosphate-selective porin K07221 - - 0.0000000000000000000000000000000000000000000000000000006247 212.0
TLS2_k127_6653893_1 PFAM Phosphate-selective porin O and P K07221 - - 0.00000000000000000000000000000000000000000000000000001588 208.0
TLS2_k127_6653893_2 UbiH UbiF VisC COQ6 K03185 - - 0.0000000000000000000000000000000002789 138.0
TLS2_k127_6663251_0 Belongs to the beta-ketoacyl-ACP synthases family K14660 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000707 509.0
TLS2_k127_6663251_1 Belongs to the UPF0758 family K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 336.0
TLS2_k127_6663251_2 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000002197 176.0
TLS2_k127_6668273_0 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 606.0
TLS2_k127_6668273_1 D-isomer specific 2-hydroxyacid dehydrogenase K00015 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 554.0
TLS2_k127_6668273_2 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 535.0
TLS2_k127_6668273_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038,K21977 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 496.0
TLS2_k127_6668273_4 ThiF family K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 360.0
TLS2_k127_6668273_5 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.00000000000000000000000000000000000000000000000000000008506 200.0
TLS2_k127_6668273_6 Bacterial SH3 domain K01876 - 6.1.1.12 0.0000000000000000000000000000000003627 138.0
TLS2_k127_6668326_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003736 586.0
TLS2_k127_6668326_1 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007614 322.0
TLS2_k127_6668326_2 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002789 273.0
TLS2_k127_6668326_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000004894 232.0
TLS2_k127_6668326_4 Binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000001667 213.0
TLS2_k127_6668326_5 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000001919 200.0
TLS2_k127_6668326_6 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000005846 165.0
TLS2_k127_6668326_7 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000008092 146.0
TLS2_k127_6668326_8 Ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000001541 101.0
TLS2_k127_667426_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003587 539.0
TLS2_k127_667426_1 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 394.0
TLS2_k127_6691421_0 Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 500.0
TLS2_k127_6691421_1 Glycosyl transferase group 2 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 300.0
TLS2_k127_6691421_2 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.000000000000000000000000000000000000000000000000000002455 199.0
TLS2_k127_6691421_3 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000002989 121.0
TLS2_k127_6691421_4 diguanylate cyclase - - - 0.00000000000000000000183 97.0
TLS2_k127_6694423_0 redox protein regulator of disulfide bond formation K07397 - - 0.00000000000000000000000000000000000000000000000000000000000000000000509 236.0
TLS2_k127_6694423_1 Leucine rich repeat - - - 0.0000000000000000000000000000000000000000000000000000000005598 214.0
TLS2_k127_6694423_2 - - - - 0.000000000000000000000000000000000001499 144.0
TLS2_k127_6694423_3 Belongs to the bacterial histone-like protein family - - - 0.000000000000000000000000000000002915 132.0
TLS2_k127_6694423_5 Transglycosylase associated protein - - - 0.00000000000000000000002505 102.0
TLS2_k127_6694423_6 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.00000000000000000000004995 108.0
TLS2_k127_6694423_7 - - - - 0.00000000002873 65.0
TLS2_k127_6694423_8 - - - - 0.000000005052 59.0
TLS2_k127_6694423_9 - - - - 0.000008665 53.0
TLS2_k127_6704016_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - - 0.0 1289.0
TLS2_k127_6704016_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1013.0
TLS2_k127_6704016_2 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05561 - - 6.086e-196 623.0
TLS2_k127_6704016_3 Belongs to the Dps family K04047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003888 254.0
TLS2_k127_6704016_4 Multisubunit Na H antiporter, MnhE subunit K05562 - - 0.00000000000000000000000000000000000000000000000000000000000000000001215 236.0
TLS2_k127_6704016_5 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000000000000000008542 167.0
TLS2_k127_6704016_6 COG1320 Multisubunit Na H antiporter, MnhG subunit K05564 - - 0.000000000000000000000000000000000000000000001665 167.0
TLS2_k127_6704016_7 Multisubunit Na H antiporter, MnhC subunit K05560 - - 0.00000000000000000000000000000000000000007289 157.0
TLS2_k127_6704016_8 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05563 - - 0.00000000000000000000000000002048 122.0
TLS2_k127_6712220_0 Peptidase dimerisation domain K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 575.0
TLS2_k127_6712220_1 Belongs to the RNase T2 family K01166,K01169 - 3.1.27.1,3.1.27.6 0.0000000000000000000000000000000000000000000000000000000008605 210.0
TLS2_k127_6712220_2 Cold-shock K03704 - - 0.000000000000000000000000000000007296 130.0
TLS2_k127_6712220_3 Glycine cleavage system T protein K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.10 0.00000000000000000004326 93.0
TLS2_k127_6712220_4 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000002643 80.0
TLS2_k127_6715510_0 DNA ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000876 478.0
TLS2_k127_6715510_1 Penicillin-Binding Protein C-terminus Family K05367 - 2.4.1.129 0.0000000000000000000000003912 108.0
TLS2_k127_6715510_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000001991 64.0
TLS2_k127_6715748_0 flagellar motor protein K02557 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 395.0
TLS2_k127_6715748_1 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 365.0
TLS2_k127_6715748_2 MotA TolQ ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 358.0
TLS2_k127_6715748_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006889 311.0
TLS2_k127_6715748_4 Protein of unknown function (DUF861) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006804 276.0
TLS2_k127_6725631_0 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 484.0
TLS2_k127_6725631_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004729 443.0
TLS2_k127_6725631_2 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000001007 153.0
TLS2_k127_6725631_3 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 0.000000000000000000000000000386 115.0
TLS2_k127_6725631_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000006188 53.0
TLS2_k127_672595_0 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 372.0
TLS2_k127_672595_1 Domain of Unknown Function (DUF1206) - - - 0.00000000000000000000000000000000000000000000000000000000000000000004577 239.0
TLS2_k127_6736004_0 ArgJ family K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001989 282.0
TLS2_k127_6736004_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006228 272.0
TLS2_k127_6736004_2 NUDIX domain K03574 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 0.00000000000000000000000000000000000000000000000000007261 190.0
TLS2_k127_6736004_3 Flp/Fap pilin component K02651 - - 0.0008134 46.0
TLS2_k127_67676_0 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 1.163e-219 691.0
TLS2_k127_67676_1 Protein of unknown function (DUF1097) - - - 0.000000000000000000000000000000000000000000000000002272 198.0
TLS2_k127_67676_2 PFAM Squalene phytoene synthase K02291,K18163 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000003875 191.0
TLS2_k127_67676_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000002361 132.0
TLS2_k127_6774738_0 Protease II K01354 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 1.537e-213 675.0
TLS2_k127_6774738_1 ROS/MUCR transcriptional regulator protein - - - 0.000000000000000000000000000000000000000000000000000000000236 207.0
TLS2_k127_6774738_2 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000003248 90.0
TLS2_k127_6774738_3 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000001142 65.0
TLS2_k127_6774738_4 methionine sulfoxide reductase K07305 - 1.8.4.12 0.00000001584 60.0
TLS2_k127_6776267_0 Stimulus-sensing domain K14980 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 5.562e-212 674.0
TLS2_k127_6776267_1 Transcriptional regulatory protein, C terminal K14981 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004303 398.0
TLS2_k127_6776267_10 Prokaryotic cytochrome b561 - - - 0.0000000194 59.0
TLS2_k127_6776267_2 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 317.0
TLS2_k127_6776267_3 pyridoxamine 5'-phosphate K07226 - - 0.00000000000000000000000000000000000000000000000000000000000000004969 233.0
TLS2_k127_6776267_4 PTS system fructose IIA component K02793 - 2.7.1.191 0.000000000000000000000000000000000000000000000000000000007678 202.0
TLS2_k127_6776267_5 Tyrosine phosphatase family - - - 0.00000000000000000000000000000000000000000000001648 179.0
TLS2_k127_6776267_6 cytochrome - - - 0.000000000000000000000000000000000000007328 148.0
TLS2_k127_6776267_7 HPr Serine kinase C-terminal domain K06023 - - 0.00000000000000000000000000004476 125.0
TLS2_k127_6776267_8 PTS HPr component phosphorylation site K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006808,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0044424,GO:0044464,GO:0050789,GO:0051179,GO:0051234,GO:0065007,GO:0071702 - 0.0000000000000000000000000761 111.0
TLS2_k127_6776267_9 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 0.000000001499 64.0
TLS2_k127_677893_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 457.0
TLS2_k127_677893_1 Ubiquinol-cytochrome C chaperone K17662 - - 0.00000000000000000000000000009277 122.0
TLS2_k127_677893_2 SmpA / OmlA family - - - 0.000000000000000000000000009454 117.0
TLS2_k127_6791206_0 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000004764 218.0
TLS2_k127_6791206_1 Linear amide C-N hydrolases, choloylglycine hydrolase family K01442 - 3.5.1.24 0.000000000000000000000000000000000000000000000000002479 187.0
TLS2_k127_6791206_2 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.000000000000000000000000000000004431 130.0
TLS2_k127_6791206_3 - - - - 0.000000000000000002567 87.0
TLS2_k127_6792076_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 1.714e-233 728.0
TLS2_k127_6792076_1 Glycine cleavage system T protein K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 410.0
TLS2_k127_6792076_2 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000000001502 188.0
TLS2_k127_6794901_0 Belongs to the peptidase S11 family K01286 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006846 299.0
TLS2_k127_6794901_1 TIR domain - - - 0.00000000000000000000003471 103.0
TLS2_k127_6794901_2 - - - - 0.00000000002217 72.0
TLS2_k127_6810431_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 7.925e-321 994.0
TLS2_k127_6810431_1 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000492 484.0
TLS2_k127_6829931_0 Transcription elongation factor - - - 0.00000000000000000000000000000000000000000000000000000000000000007929 224.0
TLS2_k127_6829931_1 - - - - 0.00000000000000000000000000000000000009247 156.0
TLS2_k127_6829931_2 Rdx family K07401 - - 0.00000000000000000000000000000000006324 136.0
TLS2_k127_6829931_3 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) - - - 0.0000000000000000000000000001302 119.0
TLS2_k127_6829931_4 Ammonium Transporter Family K03320 - - 0.00000000000003502 72.0
TLS2_k127_6851852_0 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004289 546.0
TLS2_k127_6851852_1 Pyridoxal-phosphate dependent enzyme K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009651 467.0
TLS2_k127_6851852_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 350.0
TLS2_k127_6851852_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005015 338.0
TLS2_k127_6901842_0 Domain of unknown function DUF21 K03699 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 392.0
TLS2_k127_6901842_1 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000000000000000000000000000000000000002793 211.0
TLS2_k127_6901842_2 BolA-like protein K05527,K22066 GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564 - 0.0000000000000000000000482 111.0
TLS2_k127_6901842_3 Cobaltochelatase CobS subunit N terminal K09882 - 6.6.1.2 0.00002354 48.0
TLS2_k127_6913_0 Involved in the TonB-independent uptake of proteins K03641 - - 2.321e-201 636.0
TLS2_k127_6913_1 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000000000000000000000000001701 219.0
TLS2_k127_6913_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000000000000001292 215.0
TLS2_k127_6913_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000000000000001673 181.0
TLS2_k127_6913_4 Membrane - - - 0.0000000004921 60.0
TLS2_k127_6937348_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008840,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0071704 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 436.0
TLS2_k127_6937348_1 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 310.0
TLS2_k127_6937348_2 UreE urease accessory protein, C-terminal domain K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002865 276.0
TLS2_k127_6937348_3 Transglycosylase SLT domain K08309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006638 279.0
TLS2_k127_6937348_4 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000000000000000000111 204.0
TLS2_k127_6937348_5 Redoxin domain protein - - - 0.000000000000000000000000000000000000000000000000000000003017 208.0
TLS2_k127_6937348_6 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000000000000000000000000000000004789 173.0
TLS2_k127_6937348_7 Protein of unknown function (DUF3775) - - - 0.0000000000000000000000000000000000000007331 151.0
TLS2_k127_6937348_8 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950,K13940 - 2.7.6.3,4.1.2.25 0.000000000000000000000000000000000000006183 152.0
TLS2_k127_6937348_9 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 0.00000000000000000000000000000192 120.0
TLS2_k127_6951689_0 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 468.0
TLS2_k127_6951689_1 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000000000000000000005637 202.0
TLS2_k127_6951689_2 molybdopterin-guanine dinucleotide biosynthesis protein K03753 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000001317 195.0
TLS2_k127_6951689_3 Amino acid ABC transporter substrate-binding protein K02030 - - 0.000000000000000000000000000000000000001668 161.0
TLS2_k127_6951689_4 Formate dehydrogenase subunit alpha - - - 0.00000000000001318 74.0
TLS2_k127_6969563_0 Formate--tetrahydrofolate ligase K01938 - 6.3.4.3 3.815e-213 666.0
TLS2_k127_6969563_1 PFAM aminotransferase class V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 1.017e-197 623.0
TLS2_k127_6969563_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00018 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 497.0
TLS2_k127_6969563_3 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000739 400.0
TLS2_k127_6969563_4 PFAM Formiminotransferase-cyclodeaminase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003417 252.0
TLS2_k127_7011478_0 ABC transporter K02471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 346.0
TLS2_k127_7011478_1 phosphohistidine phosphatase, SixA - - - 0.000000000000000000000000000000000000000000000000000000000000000000002259 241.0
TLS2_k127_7017520_0 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 349.0
TLS2_k127_7017520_1 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000000000000000000000000000000000000000000005081 180.0
TLS2_k127_703254_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 487.0
TLS2_k127_703254_1 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000006747 175.0
TLS2_k127_703254_2 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 0.000000000004231 69.0
TLS2_k127_7085952_0 Histidine kinase K11527 - 2.7.13.3 8.92e-205 658.0
TLS2_k127_7085952_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001625 279.0
TLS2_k127_7085952_2 COG1073 Hydrolases of the alpha beta superfamily K06889 - - 0.000000000000000000007153 94.0
TLS2_k127_7087966_0 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 441.0
TLS2_k127_7087966_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000001238 146.0
TLS2_k127_7087966_2 Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) - - - 0.0002964 44.0
TLS2_k127_7150026_0 Transglycosylase associated protein - - - 0.000000000000000000000000000001862 122.0
TLS2_k127_7150026_1 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000000000000006211 124.0
TLS2_k127_7150026_2 - - - - 0.000000000000000002126 88.0
TLS2_k127_7159269_0 Binding-protein-dependent transport system inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003837 533.0
TLS2_k127_7159269_1 Bacterial extracellular solute-binding protein K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004453 278.0
TLS2_k127_7159269_2 AsmA-like C-terminal region K07289 - - 0.0000000000000000000001014 114.0
TLS2_k127_7164386_0 COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - 2.761e-202 634.0
TLS2_k127_7164386_1 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004517 307.0
TLS2_k127_7164386_2 Cobalamin synthesis protein cobW C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002756 262.0
TLS2_k127_7169908_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1001.0
TLS2_k127_7169908_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000001279 214.0
TLS2_k127_7169908_2 - - - - 0.000000001376 64.0
TLS2_k127_7188221_0 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003258 259.0
TLS2_k127_7242425_0 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 7.063e-270 865.0
TLS2_k127_7242425_1 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 6.961e-259 836.0
TLS2_k127_7242425_2 PFAM Nucleotidyl transferase K00966,K00992 - 2.7.7.13,2.7.7.99 0.00000000000000000000000000000000000000000000647 166.0
TLS2_k127_7251442_0 - - - - 0.00000000000000000000000000000000000214 145.0
TLS2_k127_7251442_1 Phage integrase family - - - 0.0000000000000000000001988 101.0
TLS2_k127_7297121_0 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007274 394.0
TLS2_k127_7297121_2 metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000000004306 191.0
TLS2_k127_7297121_3 - - - - 0.0000000000000002247 91.0
TLS2_k127_7299718_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1324.0
TLS2_k127_7299718_1 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 370.0
TLS2_k127_7299718_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 302.0
TLS2_k127_7324758_0 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 402.0
TLS2_k127_7324758_1 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000341 166.0
TLS2_k127_7324758_2 Short repeat of unknown function (DUF308) - - - 0.00001554 54.0
TLS2_k127_7370719_0 Beta-lactamase K18988 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 380.0
TLS2_k127_7370719_1 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.00000000000000000000000000000001207 133.0
TLS2_k127_7370719_2 Protein of unknown function (DUF1150) - - - 0.000000000000000002792 87.0
TLS2_k127_7400522_0 ATP:dephospho-CoA triphosphoribosyl transferase K05966 - 2.4.2.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000711 289.0
TLS2_k127_7400522_1 Formaldehyde-activating enzyme (Fae) K10713 - 4.2.1.147 0.00000000000000000000000000000000000000000000000000000000000000000000000000001436 261.0
TLS2_k127_7400522_2 RimK-like ATP-grasp domain K05844 - - 0.000000000000000000000000000000000000007168 149.0
TLS2_k127_7436024_0 Cytochrome P450 K15468 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008788 580.0
TLS2_k127_7436024_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 393.0
TLS2_k127_7436024_2 Haloacid dehalogenase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 382.0
TLS2_k127_7436024_3 Cytochrome C oxidase, cbb3-type, subunit III K19713 - 1.8.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 315.0
TLS2_k127_766902_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 512.0
TLS2_k127_766902_1 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007023 483.0
TLS2_k127_766902_2 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000000000000000000000000001896 158.0
TLS2_k127_766902_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000004254 151.0
TLS2_k127_766902_4 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000003801 135.0
TLS2_k127_766902_5 of tumorigenicity 14 K01312,K01324,K08670 - 3.4.21.109,3.4.21.34,3.4.21.4 0.000000002574 58.0
TLS2_k127_766902_6 receptor - - - 0.000006976 50.0
TLS2_k127_784274_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.00000000000003699 72.0
TLS2_k127_784274_1 Cupin 2, conserved barrel domain protein - - - 0.00000002093 63.0
TLS2_k127_784274_2 - - - - 0.00003692 49.0
TLS2_k127_790886_0 ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 309.0
TLS2_k127_790886_1 Integral membrane protein TerC family - - - 0.0000000000000000000000000000000000000004649 151.0
TLS2_k127_790886_2 Belongs to the ompA family K03286 - - 0.000000000000000000000000000000005315 142.0
TLS2_k127_790886_3 sh3 domain protein - - - 0.00000000000000000000001162 104.0
TLS2_k127_790886_4 Pentapeptide repeats (9 copies) - - - 0.000000000000005442 83.0
TLS2_k127_790886_5 TonB C terminal K03832 - - 0.0000000008618 71.0
TLS2_k127_790886_6 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000115 60.0
TLS2_k127_790886_7 Protein of unknown function (DUF3096) - - - 0.00000000346 61.0
TLS2_k127_790886_8 Resolvase, N terminal domain - - - 0.0000008948 51.0
TLS2_k127_79313_0 Sodium:sulfate symporter transmembrane region - - - 0.00000000000000000000001303 99.0
TLS2_k127_79313_1 AsmA family K07289,K07290 - - 0.000000009644 68.0
TLS2_k127_79313_2 Leucyl aminopeptidase (Aminopeptidase t) - - - 0.000001546 59.0
TLS2_k127_84770_0 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 4.115e-203 644.0
TLS2_k127_937123_0 Cation transport ATPase (P-type) K01537 - 3.6.3.8 0.0 1074.0
TLS2_k127_937123_1 nucleoside-triphosphate diphosphatase activity K06287 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006346 277.0
TLS2_k127_937123_2 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000000000005198 149.0
TLS2_k127_937123_3 Cupin 2 conserved barrel domain protein - - - 0.0000000000000000000000000005539 114.0
TLS2_k127_937123_4 Universal stress protein UspA - - - 0.0000000000000000000000000007552 124.0
TLS2_k127_937123_5 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000001968 78.0
TLS2_k127_937123_6 Universal stress protein UspA - - - 0.0000000000005705 70.0
TLS2_k127_937123_7 Resolvase - - - 0.00000004247 56.0
TLS2_k127_9590_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 4.447e-223 709.0
TLS2_k127_9590_1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004635 271.0
TLS2_k127_9590_2 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000000000000001157 199.0
TLS2_k127_965320_0 COG4772 Outer membrane receptor for Fe3 -dicitrate K16091 - - 9.618e-206 659.0
TLS2_k127_965320_1 May be involved in the transport of PQQ or its precursor to the periplasm K06136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 406.0
TLS2_k127_965320_2 Histidine kinase K07675 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 331.0
TLS2_k127_965320_3 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001294 274.0
TLS2_k127_965320_4 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000007637 195.0
TLS2_k127_965320_5 CHAD - - - 0.0000000000000000000000000000000000000000000005769 179.0
TLS2_k127_965320_6 Peptidase propeptide and YPEB domain - - - 0.0000000000000000000000000001161 116.0
TLS2_k127_969228_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 462.0
TLS2_k127_969228_1 alcohol dehydrogenase K00001,K00043 - 1.1.1.1,1.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 391.0
TLS2_k127_969228_2 Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000002301 222.0
TLS2_k127_969652_0 MMPL family K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003664 287.0
TLS2_k127_988993_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700 1.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 510.0
TLS2_k127_988993_1 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 293.0
TLS2_k127_988993_2 Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000001289 210.0
TLS2_k127_988993_3 HNH endonuclease - - - 0.00000000000000000000000000000000652 136.0
TLS2_k127_992701_0 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 514.0
TLS2_k127_992701_1 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 452.0