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Overview

ID MAG04011
Name TLS2_bin.5
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Gemmatimonadota
Class Gemmatimonadetes
Order Longimicrobiales
Family RSA9
Genus JBFJPA01
Species
Assembly information
Completeness (%) 88.82
Contamination (%) 2.63
GC content (%) 68.0
N50 (bp) 25,249
Genome size (bp) 4,531,276

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3506

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1003043_0 B12 binding domain K04034 - 1.21.98.3 1.185e-235 751.0
TLS2_k127_1003043_1 radical SAM domain protein K04034 - 1.21.98.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 604.0
TLS2_k127_1003043_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 325.0
TLS2_k127_1003043_3 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004644 298.0
TLS2_k127_1003043_4 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000001498 271.0
TLS2_k127_1003043_5 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000004075 222.0
TLS2_k127_1003043_6 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.0000000000000000000000000000000000000000000006612 175.0
TLS2_k127_1003043_7 Arylsulfotransferase (ASST) - - - 0.0000000000000001619 92.0
TLS2_k127_1004866_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 0.0 1042.0
TLS2_k127_1004866_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004518 560.0
TLS2_k127_1004866_10 Fumarate reductase, iron-sulfur protein K00240,K00245 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 372.0
TLS2_k127_1004866_11 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 364.0
TLS2_k127_1004866_12 e3 binding domain K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 364.0
TLS2_k127_1004866_13 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004708 293.0
TLS2_k127_1004866_14 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001668 263.0
TLS2_k127_1004866_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000002519 261.0
TLS2_k127_1004866_16 - K00241 - - 0.00000000000000000000000000000000000000000000000000000000000000000001808 243.0
TLS2_k127_1004866_17 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000104 235.0
TLS2_k127_1004866_18 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000001945 213.0
TLS2_k127_1004866_19 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000002669 207.0
TLS2_k127_1004866_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005059 474.0
TLS2_k127_1004866_20 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000525 200.0
TLS2_k127_1004866_21 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.0000000000000000000000000000000000000000000000002359 186.0
TLS2_k127_1004866_22 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000252 176.0
TLS2_k127_1004866_23 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000005636 173.0
TLS2_k127_1004866_24 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 - 1.6.5.3 0.0000000000000000000000000000000004624 134.0
TLS2_k127_1004866_25 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000001325 139.0
TLS2_k127_1004866_26 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000000000000228 134.0
TLS2_k127_1004866_27 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000008297 135.0
TLS2_k127_1004866_28 Telomere recombination K07566 - 2.7.7.87 0.0000000000000000000000000000001587 138.0
TLS2_k127_1004866_29 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.0000000000000000000000000000002231 125.0
TLS2_k127_1004866_3 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 470.0
TLS2_k127_1004866_30 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000005036 127.0
TLS2_k127_1004866_31 Phosphoribosyl transferase domain - - - 0.00000000000000000000004953 115.0
TLS2_k127_1004866_32 Preprotein translocase SecG subunit K03075 - - 0.0000000000000000004699 91.0
TLS2_k127_1004866_33 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits - - - 0.00000000000000003644 83.0
TLS2_k127_1004866_4 Phosphoglycerate kinase K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005666 471.0
TLS2_k127_1004866_5 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004558 454.0
TLS2_k127_1004866_6 Transketolase, pyrimidine binding domain K00167,K11381,K21417 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005128 437.0
TLS2_k127_1004866_7 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003178 424.0
TLS2_k127_1004866_8 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007092 413.0
TLS2_k127_1004866_9 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 389.0
TLS2_k127_1009553_0 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide - - - 2.886e-270 857.0
TLS2_k127_1009553_1 PFAM NADH Ubiquinone plastoquinone (complex I) K05568 - - 1.526e-196 623.0
TLS2_k127_1009553_10 CHRD domain - - - 0.00000000000000000000000000000000000000000000212 171.0
TLS2_k127_1009553_11 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000001384 157.0
TLS2_k127_1009553_12 ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component - - - 0.000000000000000000000000000000001079 137.0
TLS2_k127_1009553_13 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000003196 129.0
TLS2_k127_1009553_14 Domain related to MnhB subunit of Na+/H+ antiporter - - - 0.0000000000000000000000000001634 126.0
TLS2_k127_1009553_15 monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.00000000000000000000000001614 114.0
TLS2_k127_1009553_16 oxidoreductase, chain 4L K05567 - - 0.0000000000000000000000001375 112.0
TLS2_k127_1009553_17 Sigma-70 region 2 K03088 - - 0.000000000000000000001818 104.0
TLS2_k127_1009553_18 Na+/H+ ion antiporter subunit K05569 - - 0.000000000000000000002103 108.0
TLS2_k127_1009553_19 Domain of unknown function (DUF4040) K05566 - - 0.00000000000000000001687 94.0
TLS2_k127_1009553_2 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006095 587.0
TLS2_k127_1009553_20 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.000000000000000000107 92.0
TLS2_k127_1009553_21 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000001428 70.0
TLS2_k127_1009553_3 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 461.0
TLS2_k127_1009553_4 COG2217 Cation transport ATPase K01534 - 3.6.3.3,3.6.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 406.0
TLS2_k127_1009553_5 PFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 391.0
TLS2_k127_1009553_6 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004523 399.0
TLS2_k127_1009553_7 Phospholipase D. Active site motifs. K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 353.0
TLS2_k127_1009553_8 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009521 315.0
TLS2_k127_1009553_9 Peptidase M16 inactive domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 302.0
TLS2_k127_1045566_0 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 321.0
TLS2_k127_1045566_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000007602 209.0
TLS2_k127_1045566_2 metallocarboxypeptidase activity - - - 0.000000000000000000000000000000000000000000000000005085 200.0
TLS2_k127_1045566_3 Bacterial protein of unknown function (DUF885) - - - 0.00000001644 55.0
TLS2_k127_1054668_0 TonB-dependent receptor K16089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007915 619.0
TLS2_k127_1054668_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008863 628.0
TLS2_k127_1054668_10 PFAM TrkA-N domain protein K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 343.0
TLS2_k127_1054668_11 TrkA-N domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001169 273.0
TLS2_k127_1054668_12 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.0000000000000000000000000000000000000000000000000000000000000009772 233.0
TLS2_k127_1054668_13 Thioredoxin-like - - - 0.000000000000000000000000000001071 129.0
TLS2_k127_1054668_14 Putative lumazine-binding - - - 0.0000000000000000000000000269 113.0
TLS2_k127_1054668_15 Disulphide bond corrector protein DsbC K04084 - 1.8.1.8 0.0000000000000003264 87.0
TLS2_k127_1054668_16 CopC domain K07156 - - 0.0000000000001315 78.0
TLS2_k127_1054668_17 - - - - 0.0000000000008847 78.0
TLS2_k127_1054668_2 COG1226 Kef-type K transport systems - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 514.0
TLS2_k127_1054668_3 Cation transport protein K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007249 498.0
TLS2_k127_1054668_4 Cation transport protein K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 450.0
TLS2_k127_1054668_5 PFAM ABC-3 protein K11709 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009415 437.0
TLS2_k127_1054668_6 ABC 3 transport family K11708 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000814 388.0
TLS2_k127_1054668_7 ATPases associated with a variety of cellular activities K09820,K11710 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000998 374.0
TLS2_k127_1054668_8 Belongs to the bacterial solute-binding protein 9 family K09818,K11707 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 361.0
TLS2_k127_1054668_9 prohibitin homologues K07192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008048 350.0
TLS2_k127_112906_0 Zinc carboxypeptidase - - - 1.909e-303 960.0
TLS2_k127_112906_1 PFAM AMP-dependent synthetase and ligase K01907 - 6.2.1.16 2.033e-257 809.0
TLS2_k127_112906_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004665 407.0
TLS2_k127_112906_11 MFS/sugar transport protein K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 361.0
TLS2_k127_112906_12 RmlD substrate binding domain K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 329.0
TLS2_k127_112906_13 Fungal family of unknown function (DUF1776) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004967 287.0
TLS2_k127_112906_14 Phospholipase/Carboxylesterase K06999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000207 278.0
TLS2_k127_112906_15 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005023 278.0
TLS2_k127_112906_16 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003345 276.0
TLS2_k127_112906_17 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000001087 293.0
TLS2_k127_112906_18 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000005682 261.0
TLS2_k127_112906_19 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000007847 133.0
TLS2_k127_112906_2 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006675 590.0
TLS2_k127_112906_20 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000248 107.0
TLS2_k127_112906_22 PFAM phosphoesterase, PA-phosphatase related - - - 0.000000000000000000117 100.0
TLS2_k127_112906_23 - - - - 0.000000000000000002424 91.0
TLS2_k127_112906_24 - - - - 0.00000007156 57.0
TLS2_k127_112906_3 Alcohol dehydrogenase GroES-like domain K00008,K00148 - 1.1.1.14,1.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 565.0
TLS2_k127_112906_4 inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 541.0
TLS2_k127_112906_5 Berberine and berberine like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 532.0
TLS2_k127_112906_6 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 511.0
TLS2_k127_112906_7 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005966 507.0
TLS2_k127_112906_8 PFAM Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 469.0
TLS2_k127_112906_9 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 416.0
TLS2_k127_1135021_0 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 462.0
TLS2_k127_1135021_1 phenylacetic acid catabolic K02609 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 397.0
TLS2_k127_1135021_10 OsmC-like protein K04063 - - 0.0000000000000000000000000000000000000000001262 166.0
TLS2_k127_1135021_11 Belongs to the DEAD box helicase family K05592,K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 0.00000000000000000000000000000000000005793 162.0
TLS2_k127_1135021_12 PFAM phenylacetic acid catabolic family protein K02611 - 1.14.13.149 0.00000000000000000000000000000000001399 147.0
TLS2_k127_1135021_13 Pfam:DUF59 - - - 0.00000000000000000000000000000911 126.0
TLS2_k127_1135021_14 DSBA-like thioredoxin domain - - - 0.000000000000000000000000006519 119.0
TLS2_k127_1135021_15 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000000001199 102.0
TLS2_k127_1135021_16 - - - - 0.00000000006788 66.0
TLS2_k127_1135021_17 Iron-sulfur cluster assembly protein K02612 - - 0.00001442 49.0
TLS2_k127_1135021_18 zinc ion binding K11997,K12026 - 2.3.2.27 0.0004906 52.0
TLS2_k127_1135021_19 - - - - 0.0008567 50.0
TLS2_k127_1135021_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007732 386.0
TLS2_k127_1135021_3 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 316.0
TLS2_k127_1135021_4 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000295 267.0
TLS2_k127_1135021_5 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002687 237.0
TLS2_k127_1135021_6 Fructosamine kinase - - - 0.00000000000000000000000000000000000000000000000000000000001782 217.0
TLS2_k127_1135021_7 PFAM NAD dependent epimerase dehydratase family K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000003915 196.0
TLS2_k127_1135021_8 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000000001542 177.0
TLS2_k127_1135021_9 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000008284 185.0
TLS2_k127_1137506_0 Peptidase family M28 - - - 2.342e-194 624.0
TLS2_k127_1137506_1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 616.0
TLS2_k127_1137506_10 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000006704 226.0
TLS2_k127_1137506_11 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.00000000000000000000000000000000000000000000000000000000001018 211.0
TLS2_k127_1137506_12 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000000000002465 201.0
TLS2_k127_1137506_13 Protein of unknown function (DUF520) K09767 - - 0.000000000000000000000000000000000000000000000000001857 190.0
TLS2_k127_1137506_14 - - - - 0.00000000000000000000000000000000000000000000000001199 201.0
TLS2_k127_1137506_15 Protein involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and nitrogen compound metabolic process - - - 0.000000000000000000000000000000000000000000001448 175.0
TLS2_k127_1137506_16 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000002489 162.0
TLS2_k127_1137506_17 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000001486 161.0
TLS2_k127_1137506_18 Rho termination factor, N-terminal domain - - - 0.0000000000000000000000000000000004646 134.0
TLS2_k127_1137506_19 Preprotein translocase subunit YajC K03210 - - 0.0000000000001477 76.0
TLS2_k127_1137506_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 527.0
TLS2_k127_1137506_20 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000007279 76.0
TLS2_k127_1137506_21 Methyltransferase FkbM domain - - - 0.00000006764 59.0
TLS2_k127_1137506_22 TonB-dependent receptor plug - - - 0.0000107 54.0
TLS2_k127_1137506_3 Winged helix DNA-binding domain K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 493.0
TLS2_k127_1137506_4 Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 483.0
TLS2_k127_1137506_5 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 485.0
TLS2_k127_1137506_6 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 469.0
TLS2_k127_1137506_7 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005924 389.0
TLS2_k127_1137506_8 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 297.0
TLS2_k127_1137506_9 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002788 249.0
TLS2_k127_1140044_0 PFAM Integral membrane protein TerC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006768 371.0
TLS2_k127_1140044_1 PFAM amino acid permease-associated region K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 359.0
TLS2_k127_1140044_10 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000001449 55.0
TLS2_k127_1140044_11 NHL repeat - - - 0.0003077 52.0
TLS2_k127_1140044_2 MotA/TolQ/ExbB proton channel family K03562 - - 0.000000000000000000000000000000000000000000000000000000000002872 218.0
TLS2_k127_1140044_3 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000002262 203.0
TLS2_k127_1140044_4 Sodium:dicarboxylate symporter family K11102 - - 0.0000000000000000000000000000000000000000638 155.0
TLS2_k127_1140044_5 Biopolymer transport protein ExbD/TolR K03560 - - 0.0000000000000000000000000004854 119.0
TLS2_k127_1140044_6 Peptidase family M1 domain K01992 - - 0.0000000000000000000000003578 113.0
TLS2_k127_1140044_7 Biopolymer transport protein ExbD/TolR K03559 - - 0.0000000000000000000001363 104.0
TLS2_k127_1140044_8 Sodium:dicarboxylate symporter family K11102 - - 0.00000000001651 74.0
TLS2_k127_1140044_9 TIGRFAM TonB family protein K03832 - - 0.00000004106 64.0
TLS2_k127_1177435_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009593 386.0
TLS2_k127_1177435_1 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 334.0
TLS2_k127_1177435_10 HxlR-like helix-turn-helix - - - 0.000000000000000005493 87.0
TLS2_k127_1177435_13 Sigma factor PP2C-like phosphatases - - - 0.0000000003016 65.0
TLS2_k127_1177435_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002922 269.0
TLS2_k127_1177435_3 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000006877 214.0
TLS2_k127_1177435_4 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000003475 209.0
TLS2_k127_1177435_5 DNA-templated transcription, initiation K02405 - - 0.0000000000000000000000000000000000000000000000000004095 194.0
TLS2_k127_1177435_6 Two component regulator three Y domain protein - - - 0.000000000000000000000000000000002703 141.0
TLS2_k127_1177435_7 FG-GAP repeat - - - 0.000000000000000000000000001485 132.0
TLS2_k127_1177435_9 SnoaL-like domain - - - 0.0000000000000000008764 95.0
TLS2_k127_1180056_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 3505.0
TLS2_k127_1180056_1 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009071 551.0
TLS2_k127_1180056_2 PFAM Peptidase M29, aminopeptidase II K19689 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 475.0
TLS2_k127_1180056_3 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 459.0
TLS2_k127_1180056_4 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005077 407.0
TLS2_k127_1180056_5 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008997 312.0
TLS2_k127_1180056_6 Phosphorylase superfamily K11783 - 3.2.2.26 0.00000000000000000000000000000000000000000000000000000000000000003488 230.0
TLS2_k127_1180056_8 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.00000000000000000000000000000000000000000000000137 186.0
TLS2_k127_1180056_9 nucleic acid-binding protein contains PIN domain - - - 0.00000000000000000000000000000000000008764 145.0
TLS2_k127_127114_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 563.0
TLS2_k127_127114_1 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 494.0
TLS2_k127_127114_2 amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 352.0
TLS2_k127_127114_3 OsmC-like protein - - - 0.000000000000000000000000000000001036 138.0
TLS2_k127_1284897_0 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 444.0
TLS2_k127_1284897_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006332 413.0
TLS2_k127_1284897_2 Outer membrane protein beta-barrel family - - - 0.0000000000000000000000000000000000000000000000000000000004731 221.0
TLS2_k127_1284897_3 DinB superfamily K07552 - - 0.000000000000000000000000000000000000000039 159.0
TLS2_k127_1284897_4 phosphorelay signal transduction system K12132 - 2.7.11.1 0.00000000000000000000000000000003819 139.0
TLS2_k127_1284897_5 membrane K00389 - - 0.00000000000000000551 89.0
TLS2_k127_1284897_6 PFAM NHL repeat containing protein - - - 0.00002013 57.0
TLS2_k127_1301257_0 LVIVD repeat - - - 1.017e-214 687.0
TLS2_k127_1301257_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 426.0
TLS2_k127_1301257_11 zinc ion binding K11997,K12026,K12035 - 2.3.2.27 0.00003369 56.0
TLS2_k127_1301257_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.0001048 56.0
TLS2_k127_1301257_13 Putative restriction endonuclease - - - 0.0002075 48.0
TLS2_k127_1301257_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 337.0
TLS2_k127_1301257_3 phosphorelay signal transduction system K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000008753 253.0
TLS2_k127_1301257_4 PFAM alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000001241 193.0
TLS2_k127_1301257_5 ECF sigma factor - - - 0.000000000000000000000000000000000000000000003863 171.0
TLS2_k127_1301257_6 Domain of unknown function (DUF305) - - - 0.00000000000000000000000000000000000000000001638 170.0
TLS2_k127_1301257_7 Putative restriction endonuclease - - - 0.00000000000000000000000001487 119.0
TLS2_k127_132210_0 TonB-dependent Receptor Plug Domain K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 464.0
TLS2_k127_132210_1 dna ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 432.0
TLS2_k127_132210_2 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 373.0
TLS2_k127_132210_3 M61 glycyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 351.0
TLS2_k127_132210_4 - - - - 0.00000000000000000000000000000000000000000000000000009788 198.0
TLS2_k127_132210_5 Belongs to the UPF0235 family K09131 - - 0.00000000000000000001153 99.0
TLS2_k127_1387161_0 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006345 385.0
TLS2_k127_1387161_1 PFAM DHH family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006773 384.0
TLS2_k127_1387161_10 HIT domain K02503 - - 0.000000000000000000000000000000003292 139.0
TLS2_k127_1387161_11 - - - - 0.0000000000000000000000002858 116.0
TLS2_k127_1387161_12 HNH nucleases - - - 0.00000000000000000000002568 106.0
TLS2_k127_1387161_13 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - 0.0000000000000000000005124 101.0
TLS2_k127_1387161_14 Pyridoxal-phosphate dependent enzyme - - - 0.00000000001913 69.0
TLS2_k127_1387161_15 - - - - 0.00000000005404 69.0
TLS2_k127_1387161_2 PFAM Alcohol dehydrogenase, zinc-binding K00001 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 353.0
TLS2_k127_1387161_4 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 293.0
TLS2_k127_1387161_5 Glycosyl transferase family 21 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 299.0
TLS2_k127_1387161_6 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002416 276.0
TLS2_k127_1387161_7 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000002264 198.0
TLS2_k127_1387161_8 NUDIX domain - - - 0.00000000000000000000000000000000000000007899 157.0
TLS2_k127_1387161_9 PFAM MazG nucleotide pyrophosphohydrolase - - - 0.000000000000000000000000000000000003859 145.0
TLS2_k127_1439813_0 ATP dependent DNA ligase domain protein K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 585.0
TLS2_k127_1439813_1 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 512.0
TLS2_k127_1439813_10 Uncharacterized conserved protein (DUF2183) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006429 274.0
TLS2_k127_1439813_11 Glycogen debranching enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003008 267.0
TLS2_k127_1439813_12 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001749 261.0
TLS2_k127_1439813_13 Pfam Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000001299 224.0
TLS2_k127_1439813_14 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000004616 207.0
TLS2_k127_1439813_15 Protein of unknown function (DUF3500) - - - 0.000000000000000000000000000000000000000000000000005908 204.0
TLS2_k127_1439813_16 regulator - - - 0.000000000000000000000000000000000000000000005981 174.0
TLS2_k127_1439813_17 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000000000544 162.0
TLS2_k127_1439813_18 - - - - 0.0000000000000000000000000000000000579 138.0
TLS2_k127_1439813_19 Domain of unknown function (DUF4389) - - - 0.00000000000000000000000001457 118.0
TLS2_k127_1439813_2 ATP dependent DNA ligase C terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004576 489.0
TLS2_k127_1439813_20 - - - - 0.0000000000000000000008022 109.0
TLS2_k127_1439813_21 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000009157 67.0
TLS2_k127_1439813_22 Carboxylesterase family - - - 0.0000000001578 74.0
TLS2_k127_1439813_23 CsbD-like - - - 0.0000001472 59.0
TLS2_k127_1439813_3 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 498.0
TLS2_k127_1439813_4 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 475.0
TLS2_k127_1439813_5 ThiF family - GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0061503,GO:0061504,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 423.0
TLS2_k127_1439813_6 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 420.0
TLS2_k127_1439813_7 aldolase K01623 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007929 408.0
TLS2_k127_1439813_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004783 400.0
TLS2_k127_1439813_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 386.0
TLS2_k127_1460641_0 Prolyl oligopeptidase family - - - 1.966e-268 859.0
TLS2_k127_1460641_1 RimK-like ATPgrasp N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 609.0
TLS2_k127_1460641_2 Glutamate-cysteine ligase family 2(GCS2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004843 408.0
TLS2_k127_1460641_3 Sodium:dicarboxylate symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 394.0
TLS2_k127_1460641_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001452 280.0
TLS2_k127_1460641_5 Bacterial PH domain - - - 0.00000000000000000000000000000000000000000000553 175.0
TLS2_k127_1460641_6 TspO/MBR family K05770 - - 0.000000000000000000000004086 105.0
TLS2_k127_1466273_0 FtsX-like permease family K02004 - - 2.731e-245 783.0
TLS2_k127_1466273_1 Belongs to the DEAD box helicase family K05592,K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 6.249e-228 719.0
TLS2_k127_1466273_10 PFAM isochorismatase hydrolase K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 305.0
TLS2_k127_1466273_11 transmembrane transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001693 275.0
TLS2_k127_1466273_12 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000003482 283.0
TLS2_k127_1466273_13 Methyltransferase small domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000175 264.0
TLS2_k127_1466273_14 ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000000829 209.0
TLS2_k127_1466273_15 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000009824 152.0
TLS2_k127_1466273_16 positive regulation of type IV pilus biogenesis K07343 - - 0.0000000000000000000000000000003093 126.0
TLS2_k127_1466273_17 VanZ like family - - - 0.000000000000000000000000000001207 132.0
TLS2_k127_1466273_18 negative regulation of transcription, DNA-templated - - - 0.0000000000000003218 88.0
TLS2_k127_1466273_2 efflux transmembrane transporter activity - - - 3.387e-218 710.0
TLS2_k127_1466273_21 outer membrane efflux protein - - - 0.00000000000008454 84.0
TLS2_k127_1466273_22 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000001961 62.0
TLS2_k127_1466273_23 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00006551 49.0
TLS2_k127_1466273_24 TonB-dependent receptor plug domain - - - 0.0004192 48.0
TLS2_k127_1466273_3 COG3263 NhaP-type Na H and K H K11105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 580.0
TLS2_k127_1466273_4 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 555.0
TLS2_k127_1466273_5 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006689 554.0
TLS2_k127_1466273_6 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 480.0
TLS2_k127_1466273_7 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 426.0
TLS2_k127_1466273_8 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 360.0
TLS2_k127_1466273_9 TIGRFAM efflux transporter, RND family, MFP subunit K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 321.0
TLS2_k127_1477691_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 6.827e-294 938.0
TLS2_k127_1477691_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.273e-247 795.0
TLS2_k127_1477691_2 Elongation factor G, domain IV K02355 - - 9.097e-236 748.0
TLS2_k127_1477691_3 Domain in cystathionine beta-synthase and other proteins. K01697 - 4.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 595.0
TLS2_k127_1477691_4 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 406.0
TLS2_k127_1477691_5 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000004118 214.0
TLS2_k127_1477691_6 Rhomboid family - - - 0.00000000000000000000000000000000000000000000004713 179.0
TLS2_k127_1477691_7 Protein of unknown function (DUF983) - - - 0.000000000000000000000000003625 116.0
TLS2_k127_1477691_8 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000008229 66.0
TLS2_k127_1477691_9 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.00000001409 67.0
TLS2_k127_1506477_0 DEAD DEAH box K03724 - - 3.563e-309 976.0
TLS2_k127_1506477_1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 1.162e-302 938.0
TLS2_k127_1506477_11 TIGRFAM cytochrome c-type biogenesis protein CcmI K02200 - - 0.00001615 58.0
TLS2_k127_1506477_2 Cellulose synthase K00694 - 2.4.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 576.0
TLS2_k127_1506477_3 PFAM peptidase dimerisation domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 544.0
TLS2_k127_1506477_4 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 387.0
TLS2_k127_1506477_5 Belongs to the glycosyl hydrolase 26 family K01179 - 3.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 379.0
TLS2_k127_1506477_6 Belongs to the FPG family K05522 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000003675 202.0
TLS2_k127_1506477_7 - - - - 0.000000000000000000000000000000000000000000000006498 187.0
TLS2_k127_1506477_8 Protein of unknown function (DUF3365) - - - 0.00000000000000000000000000000009838 131.0
TLS2_k127_1506477_9 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.0000000000000000002009 100.0
TLS2_k127_1523819_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 378.0
TLS2_k127_1523819_1 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000002974 156.0
TLS2_k127_1523819_2 Ribosomal RNA adenine dimethylase - - - 0.00000000000000000000000000000000000195 148.0
TLS2_k127_1523819_3 negative regulation of transcription, DNA-templated - - - 0.0000000000000002363 83.0
TLS2_k127_1523819_4 - - - - 0.000000002759 68.0
TLS2_k127_1523819_5 lipolytic protein G-D-S-L family - - - 0.000001147 59.0
TLS2_k127_1530035_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 1.651e-245 787.0
TLS2_k127_1530035_1 Prolyl oligopeptidase family K01303 - 3.4.19.1 4.043e-239 759.0
TLS2_k127_1530035_2 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005918 590.0
TLS2_k127_1530035_3 transporter K12942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 567.0
TLS2_k127_1530035_4 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009839 571.0
TLS2_k127_1530035_5 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 427.0
TLS2_k127_1530035_6 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006727 414.0
TLS2_k127_1530035_7 Di- and tricarboxylate transporters - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007839 266.0
TLS2_k127_1571857_0 Belongs to the TPP enzyme family K00156 - 1.2.5.1 1.225e-291 910.0
TLS2_k127_1571857_1 DEAD DEAH box K03724 - - 8.292e-245 769.0
TLS2_k127_1571857_10 Belongs to the peptidase S8 family - - - 0.0000000000000000000000007636 120.0
TLS2_k127_1571857_11 FAD linked oxidases, C-terminal domain - - - 0.00000000003466 71.0
TLS2_k127_1571857_2 ketosteroid isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008758 527.0
TLS2_k127_1571857_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009719 258.0
TLS2_k127_1571857_4 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000001171 231.0
TLS2_k127_1571857_5 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000001988 227.0
TLS2_k127_1571857_6 PFAM blue (type 1) copper domain protein K00368,K02638 - 1.7.2.1 0.000000000000000000000000000000000000000008419 167.0
TLS2_k127_1571857_7 Penicillinase repressor - - - 0.000000000000000000000000000000000000001505 154.0
TLS2_k127_1571857_8 Domain of unknown function (DUF296) K06934 - - 0.000000000000000000000000000000000006402 142.0
TLS2_k127_1571857_9 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000008967 119.0
TLS2_k127_1608087_0 TonB-dependent receptor - - - 1.756e-270 861.0
TLS2_k127_1608087_1 Bacterial extracellular solute-binding protein K02055,K05777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 376.0
TLS2_k127_1608087_2 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000001378 229.0
TLS2_k127_1608087_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000009328 188.0
TLS2_k127_1608087_4 binding-protein-dependent transport systems inner membrane component K02053 - - 0.00000000000000000000000000000000000009983 155.0
TLS2_k127_1608087_5 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000002251 144.0
TLS2_k127_1608087_6 Putative lumazine-binding - - - 0.00000000000000000000000000001219 130.0
TLS2_k127_1608087_7 putrescine transport K02054 - - 0.000000000000000000000000001191 128.0
TLS2_k127_1608087_8 - - - - 0.00000000000141 72.0
TLS2_k127_1608087_9 Secretin and TonB N terminus short domain - - - 0.0000002742 61.0
TLS2_k127_1660510_0 peptidase S9B dipeptidylpeptidase IV domain protein - - - 5.511e-230 736.0
TLS2_k127_1660510_1 Dipeptidyl peptidase IV - - - 4.794e-198 646.0
TLS2_k127_1660510_2 peptidase S9B dipeptidylpeptidase IV domain protein - - - 9.024e-196 638.0
TLS2_k127_1660510_3 peptidase S9B dipeptidylpeptidase IV domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 530.0
TLS2_k127_1660510_4 Outer membrane protein beta-barrel family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 349.0
TLS2_k127_1660510_5 Dipeptidyl peptidase IV (DPP IV) N-terminal region K01278 - 3.4.14.5 0.0000000000000000000000000000000000004766 149.0
TLS2_k127_1660510_6 SusD family K21572 - - 0.0000000000000000000000000009748 128.0
TLS2_k127_1660510_7 PFAM TonB-dependent receptor plug K02014,K16089 - - 0.00000000001109 72.0
TLS2_k127_1678918_0 efflux transmembrane transporter activity - - - 2.229e-262 834.0
TLS2_k127_1678918_1 PFAM NAD-dependent epimerase dehydratase - - - 3.127e-202 641.0
TLS2_k127_1678918_10 PFAM Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 410.0
TLS2_k127_1678918_11 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 391.0
TLS2_k127_1678918_12 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 389.0
TLS2_k127_1678918_13 Repeat of unknown function (DUF346) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 371.0
TLS2_k127_1678918_14 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005699 294.0
TLS2_k127_1678918_15 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06132 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000783 289.0
TLS2_k127_1678918_16 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001844 269.0
TLS2_k127_1678918_17 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000004721 235.0
TLS2_k127_1678918_18 peptide catabolic process K01256 - 3.4.11.2 0.00000000000000000000000000000000000000000000000000000002927 214.0
TLS2_k127_1678918_19 Domain of unknown function (DUF3377) K07763,K07994,K07995 GO:0001838,GO:0002009,GO:0002164,GO:0002165,GO:0002168,GO:0003007,GO:0003143,GO:0003144,GO:0005575,GO:0005623,GO:0006950,GO:0007155,GO:0007275,GO:0007399,GO:0007413,GO:0007417,GO:0007419,GO:0007424,GO:0007444,GO:0007503,GO:0007505,GO:0007507,GO:0007552,GO:0007560,GO:0007561,GO:0007591,GO:0008037,GO:0008038,GO:0008150,GO:0009611,GO:0009653,GO:0009790,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009987,GO:0016043,GO:0016331,GO:0022008,GO:0022411,GO:0022610,GO:0030030,GO:0030154,GO:0030182,GO:0030198,GO:0030425,GO:0031099,GO:0031175,GO:0032501,GO:0032502,GO:0034330,GO:0034769,GO:0035001,GO:0035050,GO:0035148,GO:0035150,GO:0035151,GO:0035152,GO:0035159,GO:0035239,GO:0035295,GO:0036477,GO:0040007,GO:0042060,GO:0042246,GO:0042303,GO:0042995,GO:0043005,GO:0043062,GO:0044463,GO:0044464,GO:0045216,GO:0048468,GO:0048513,GO:0048562,GO:0048563,GO:0048568,GO:0048569,GO:0048589,GO:0048598,GO:0048646,GO:0048666,GO:0048699,GO:0048707,GO:0048729,GO:0048731,GO:0048856,GO:0048869,GO:0050896,GO:0060429,GO:0060541,GO:0060560,GO:0060562,GO:0060612,GO:0061448,GO:0061564,GO:0065007,GO:0065008,GO:0071711,GO:0071840,GO:0072175,GO:0072359,GO:0090066,GO:0097156,GO:0097447,GO:0097458,GO:0106030,GO:0120025,GO:0120036,GO:0120038 3.4.24.80 0.000000000000000000000000000000000000000000000000003627 205.0
TLS2_k127_1678918_2 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 608.0
TLS2_k127_1678918_20 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000001039 198.0
TLS2_k127_1678918_21 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000003008 186.0
TLS2_k127_1678918_22 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000008965 190.0
TLS2_k127_1678918_23 helix_turn_helix multiple antibiotic resistance protein K15973 - - 0.00000000000000000000000000000000000000000002136 171.0
TLS2_k127_1678918_25 Permease MlaE K02066 - - 0.00000000000000000000000000000000000005722 154.0
TLS2_k127_1678918_26 alpha beta - - - 0.00000000000000000000000000000000000008042 152.0
TLS2_k127_1678918_27 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000001096 138.0
TLS2_k127_1678918_28 PFAM NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000003834 138.0
TLS2_k127_1678918_29 negative regulation of transcription, DNA-templated K10947 - - 0.0000000000000000000000000000000003807 135.0
TLS2_k127_1678918_3 PFAM Protein kinase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 578.0
TLS2_k127_1678918_30 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000000000001785 139.0
TLS2_k127_1678918_31 YCII-related domain - - - 0.00000000000000000000000000000004441 128.0
TLS2_k127_1678918_32 Glycosyl hydrolase family 59 - - - 0.000000000000000000000008021 117.0
TLS2_k127_1678918_33 protein conserved in bacteria (DUF2136) K19166 - - 0.00000000000000000000000982 104.0
TLS2_k127_1678918_34 transcription regulator containing HTH domain K18831 - - 0.00000000000000000000002608 105.0
TLS2_k127_1678918_35 BlaR1 peptidase M56 - - - 0.0000000000000000005157 101.0
TLS2_k127_1678918_36 Penicillinase repressor - - - 0.0000000000000000005861 93.0
TLS2_k127_1678918_37 efflux transmembrane transporter activity - - - 0.000000000000001664 87.0
TLS2_k127_1678918_38 Transcriptional regulator PadR-like family - - - 0.000000000000005292 79.0
TLS2_k127_1678918_39 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.000000000001848 79.0
TLS2_k127_1678918_4 Metallopeptidase family M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 546.0
TLS2_k127_1678918_40 PFAM NAD-dependent epimerase dehydratase - - - 0.00000000000335 67.0
TLS2_k127_1678918_41 ATP-dependent transcriptional regulator, MalT-like, LuxR family K03556 - - 0.0000000001759 75.0
TLS2_k127_1678918_43 PIN domain K07064 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045926,GO:0048519,GO:0050789,GO:0065007,GO:0071944 - 0.000000437 59.0
TLS2_k127_1678918_44 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00003865 49.0
TLS2_k127_1678918_45 amine dehydrogenase activity - - - 0.0002712 53.0
TLS2_k127_1678918_46 efflux transmembrane transporter activity - - - 0.000686 44.0
TLS2_k127_1678918_5 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 447.0
TLS2_k127_1678918_6 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003298 473.0
TLS2_k127_1678918_7 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 458.0
TLS2_k127_1678918_8 belongs to the sigma-70 factor family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 434.0
TLS2_k127_1678918_9 Acetamidase/Formamidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000613 422.0
TLS2_k127_1692454_0 Tex-like protein N-terminal domain K06959 - - 4.198e-307 959.0
TLS2_k127_1692454_1 Nitrous oxide reductase K00376 - 1.7.2.4 5.175e-301 936.0
TLS2_k127_1692454_10 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003124 356.0
TLS2_k127_1692454_11 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 325.0
TLS2_k127_1692454_12 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001284 264.0
TLS2_k127_1692454_13 TIGRFAM molybdate ABC transporter, inner membrane subunit K02018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002491 262.0
TLS2_k127_1692454_14 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000116 263.0
TLS2_k127_1692454_15 Fe-S protein K07140 GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0050896,GO:0098754 - 0.00000000000000000000000000000000000000000000000000000000000000000008674 247.0
TLS2_k127_1692454_16 lipoprotein involved in nitrous oxide reduction K19342 - - 0.0000000000000000000000000000000000000000000000000000000000000000002564 246.0
TLS2_k127_1692454_17 nitrous oxide K19341 - - 0.000000000000000000000000000000000000000000000000000000000000000001197 241.0
TLS2_k127_1692454_18 ATPase activity K01990,K19340 - - 0.00000000000000000000000000000000000000000000000000000000000000001131 233.0
TLS2_k127_1692454_19 Cysteine-rich motif following a subset of SET domains K07117 - - 0.00000000000000000000000000000000000000000000000000002933 192.0
TLS2_k127_1692454_2 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 6.506e-218 688.0
TLS2_k127_1692454_20 Gaf domain - - - 0.000000000000000000000000000000000000000000000000000238 213.0
TLS2_k127_1692454_21 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000901 183.0
TLS2_k127_1692454_22 BlaR1 peptidase M56 - - - 0.00000000000000000000000000000000000000000000007378 187.0
TLS2_k127_1692454_23 Putative lumazine-binding - - - 0.00000000000000000000000000000000000000004555 156.0
TLS2_k127_1692454_24 - - - - 0.00000000000000000000000000000000000000009479 170.0
TLS2_k127_1692454_25 Penicillinase repressor - - - 0.0000000000000000000000000000000000001628 145.0
TLS2_k127_1692454_26 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000003134 155.0
TLS2_k127_1692454_27 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000004107 133.0
TLS2_k127_1692454_28 Cytochrome c - - - 0.00000000000000000000000000000001592 132.0
TLS2_k127_1692454_29 Acid phosphatase - - - 0.0000000000000000000000000000001733 133.0
TLS2_k127_1692454_3 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 524.0
TLS2_k127_1692454_30 Helix-turn-helix domain - - - 0.00000000000000000000000001403 126.0
TLS2_k127_1692454_31 PFAM Bacterial regulatory protein, arsR family K22298 - - 0.0000000000000000000005702 99.0
TLS2_k127_1692454_32 Protein of unknown function (DUF3618) - - - 0.00000000000000000001574 105.0
TLS2_k127_1692454_33 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000002046 64.0
TLS2_k127_1692454_35 - - - - 0.000002815 55.0
TLS2_k127_1692454_36 OmpW family K07275 - - 0.000008841 58.0
TLS2_k127_1692454_37 - - - - 0.0002256 53.0
TLS2_k127_1692454_4 PFAM LmbE family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 512.0
TLS2_k127_1692454_5 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 451.0
TLS2_k127_1692454_6 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009539 390.0
TLS2_k127_1692454_7 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006957 364.0
TLS2_k127_1692454_8 Periplasmic copper-binding protein (NosD) K07218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006404 368.0
TLS2_k127_1692454_9 Belongs to the ABC transporter superfamily K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 361.0
TLS2_k127_1731624_0 Formyltetrahydrofolate synthetase K01938 - 6.3.4.3 8.469e-219 693.0
TLS2_k127_1731624_1 Cytochrome C assembly protein K02198,K04016 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - 1.751e-206 662.0
TLS2_k127_1731624_10 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009879 396.0
TLS2_k127_1731624_11 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 356.0
TLS2_k127_1731624_12 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000338 292.0
TLS2_k127_1731624_13 Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000000002859 239.0
TLS2_k127_1731624_14 RNA pseudouridylate synthase K06178 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000973 223.0
TLS2_k127_1731624_15 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.000000000000000000000000000000000000000000000000000000000000522 226.0
TLS2_k127_1731624_16 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000009448 205.0
TLS2_k127_1731624_17 ATPase activity K01990,K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000008924 177.0
TLS2_k127_1731624_18 Protein of unknown function (DUF1194) K07114 - - 0.0000000000000000000000000000000000000000000003406 177.0
TLS2_k127_1731624_19 CcmB protein K02193,K02194 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 0.000000000000000000000000000000000000000000001396 179.0
TLS2_k127_1731624_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 554.0
TLS2_k127_1731624_20 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000000000001397 176.0
TLS2_k127_1731624_21 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 0.000000000000000000000000000000000000000001696 163.0
TLS2_k127_1731624_22 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000000000000000000311 155.0
TLS2_k127_1731624_23 cell redox homeostasis K02199 - - 0.0000000000000000000000000000000000005659 149.0
TLS2_k127_1731624_24 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000001593 149.0
TLS2_k127_1731624_25 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000001882 138.0
TLS2_k127_1731624_26 COG3288 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.0000000000000000000000000000001242 126.0
TLS2_k127_1731624_27 subunit of a heme lyase K02200 - - 0.000000000000000000000000839 112.0
TLS2_k127_1731624_28 Psort location CytoplasmicMembrane, score - - - 0.000000000001467 79.0
TLS2_k127_1731624_29 rRNA binding K02968 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000001807 69.0
TLS2_k127_1731624_3 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 529.0
TLS2_k127_1731624_4 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005078 521.0
TLS2_k127_1731624_5 Na H antiporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 512.0
TLS2_k127_1731624_6 Polysaccharide biosynthesis protein K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 492.0
TLS2_k127_1731624_7 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 474.0
TLS2_k127_1731624_8 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 438.0
TLS2_k127_1731624_9 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 437.0
TLS2_k127_1757879_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.137e-294 919.0
TLS2_k127_1757879_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 3.147e-238 753.0
TLS2_k127_1757879_10 ABC transporter K01990,K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 357.0
TLS2_k127_1757879_11 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004827 334.0
TLS2_k127_1757879_12 Beta-eliminating lyase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007565 331.0
TLS2_k127_1757879_13 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 310.0
TLS2_k127_1757879_14 Peptidase M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004697 280.0
TLS2_k127_1757879_15 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000161 263.0
TLS2_k127_1757879_16 Belongs to the glycosyl hydrolase 57 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002253 255.0
TLS2_k127_1757879_17 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000006989 233.0
TLS2_k127_1757879_18 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000000000001184 226.0
TLS2_k127_1757879_19 Glycogen debranching enzyme N terminal - - - 0.00000000000000000000000000000000000000000000000000000000000077 235.0
TLS2_k127_1757879_2 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000526 584.0
TLS2_k127_1757879_20 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000002242 215.0
TLS2_k127_1757879_21 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.0000000000000000000000000000000000000000000000001872 181.0
TLS2_k127_1757879_22 carboxylic ester hydrolase activity K01175 - - 0.00000000000000000000000000000000000000000000002044 186.0
TLS2_k127_1757879_23 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.000000000000000000000000000000000000003633 157.0
TLS2_k127_1757879_24 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000002057 149.0
TLS2_k127_1757879_25 - - - - 0.00000004229 64.0
TLS2_k127_1757879_3 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 - 5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006789 529.0
TLS2_k127_1757879_4 Xaa-Pro aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 531.0
TLS2_k127_1757879_5 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009621 513.0
TLS2_k127_1757879_6 Cys/Met metabolism PLP-dependent enzyme K01758 - 4.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 512.0
TLS2_k127_1757879_7 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 472.0
TLS2_k127_1757879_8 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000685 396.0
TLS2_k127_1757879_9 GIY-YIG type nucleases (URI domain) K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 370.0
TLS2_k127_1779996_0 TonB dependent receptor - - - 4.744e-254 819.0
TLS2_k127_1779996_1 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006345 451.0
TLS2_k127_1779996_2 SusD family K21572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 316.0
TLS2_k127_1779996_3 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007429 256.0
TLS2_k127_1779996_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000017 145.0
TLS2_k127_1779996_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000005277 104.0
TLS2_k127_1779996_6 - - - - 0.00000000000000004439 86.0
TLS2_k127_1779996_7 amine dehydrogenase activity - - - 0.0003623 53.0
TLS2_k127_1811838_0 Acetyl xylan esterase (AXE1) - - - 7.173e-295 919.0
TLS2_k127_1811838_1 Sodium:solute symporter family - - - 6.377e-243 764.0
TLS2_k127_1811838_10 Peptidase M14, carboxypeptidase A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009137 312.0
TLS2_k127_1811838_11 PFAM bifunctional deaminase-reductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000204 276.0
TLS2_k127_1811838_12 OmpA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000245 286.0
TLS2_k127_1811838_13 acetylesterase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002259 252.0
TLS2_k127_1811838_14 DinB family - - - 0.000000000000000000000000000000000000000000000000000000005602 203.0
TLS2_k127_1811838_15 chaperone-mediated protein folding - - - 0.00000000000000000000004336 103.0
TLS2_k127_1811838_2 Zn_pept - - - 1.096e-224 716.0
TLS2_k127_1811838_3 3-isopropylmalate dehydratase activity K01681,K01703,K01704,K17749 - 4.2.1.3,4.2.1.33,4.2.1.35 2.381e-217 699.0
TLS2_k127_1811838_4 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 486.0
TLS2_k127_1811838_5 HI0933-like protein K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 451.0
TLS2_k127_1811838_6 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 442.0
TLS2_k127_1811838_7 D-aminopeptidase K16203 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 355.0
TLS2_k127_1811838_8 peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 340.0
TLS2_k127_1811838_9 Zn_pept - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 318.0
TLS2_k127_1849950_0 E1-E2 ATPase K01533 - 3.6.3.4 3.777e-259 815.0
TLS2_k127_1849950_1 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001658 575.0
TLS2_k127_1849950_10 Transcriptional regulator PadR-like family - - - 0.00000000000000003711 86.0
TLS2_k127_1849950_11 zinc ion binding K11997,K12026,K12035 - 2.3.2.27 0.0000768 55.0
TLS2_k127_1849950_2 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 462.0
TLS2_k127_1849950_3 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009253 417.0
TLS2_k127_1849950_4 Dioxygenase K00449 - 1.13.11.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000343 261.0
TLS2_k127_1849950_5 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000008752 233.0
TLS2_k127_1849950_6 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000000001581 156.0
TLS2_k127_1849950_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000005704 153.0
TLS2_k127_1849950_8 methylamine metabolic process K15977 - - 0.00000000000000000000000000000000000006505 149.0
TLS2_k127_1849950_9 EF hand - - - 0.000000000000000000000001145 111.0
TLS2_k127_1871975_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1534.0
TLS2_k127_1871975_1 glutamate synthase - - - 1.547e-229 723.0
TLS2_k127_1871975_10 Protein of unknown function (DUF819) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005648 272.0
TLS2_k127_1871975_11 CDP-alcohol phosphatidyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005901 248.0
TLS2_k127_1871975_12 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000000004961 152.0
TLS2_k127_1871975_13 PFAM transcriptional regulator PadR family protein - - - 0.000000000000000000000000000000004042 130.0
TLS2_k127_1871975_14 negative regulation of transcription, DNA-templated - - - 0.000000000000000000001003 104.0
TLS2_k127_1871975_15 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000004658 63.0
TLS2_k127_1871975_2 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 614.0
TLS2_k127_1871975_3 COG1680 Beta-lactamase class C and other penicillin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 541.0
TLS2_k127_1871975_4 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 522.0
TLS2_k127_1871975_5 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 503.0
TLS2_k127_1871975_6 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002798 484.0
TLS2_k127_1871975_7 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 467.0
TLS2_k127_1871975_8 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 440.0
TLS2_k127_1871975_9 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007857 385.0
TLS2_k127_1884820_0 COG0433 Predicted ATPase K06915 - - 1.475e-231 735.0
TLS2_k127_1884820_1 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 540.0
TLS2_k127_1884820_10 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000000004679 204.0
TLS2_k127_1884820_11 Di- and tricarboxylate transporters - - - 0.0000000000000000000000000000000000000000000000000000002558 205.0
TLS2_k127_1884820_12 BlaR1 peptidase M56 - - - 0.00000000000000000000000000000000000001942 159.0
TLS2_k127_1884820_13 nUDIX hydrolase K03574,K08320 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55,3.6.1.65 0.000000000000000000000000000000006594 131.0
TLS2_k127_1884820_14 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000006591 139.0
TLS2_k127_1884820_15 Penicillinase repressor - - - 0.0000000000000000000000000002931 117.0
TLS2_k127_1884820_16 Sigma-70 region 2 K03088 - - 0.000000000000000000000000006536 115.0
TLS2_k127_1884820_17 Regulator of chromosome condensation (RCC1) repeat - - - 0.00000000000000000003763 97.0
TLS2_k127_1884820_18 - - - - 0.000000000938 70.0
TLS2_k127_1884820_19 - - - - 0.0000006577 57.0
TLS2_k127_1884820_2 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 508.0
TLS2_k127_1884820_3 PAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008104 442.0
TLS2_k127_1884820_4 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 443.0
TLS2_k127_1884820_5 Putative exonuclease SbcCD, C subunit K03546 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 440.0
TLS2_k127_1884820_6 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 420.0
TLS2_k127_1884820_7 Bacterial protein of unknown function (DUF839) K07093 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008848 396.0
TLS2_k127_1884820_8 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 323.0
TLS2_k127_1884820_9 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002953 277.0
TLS2_k127_1894095_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 619.0
TLS2_k127_1894095_1 Predicted ATPase of the ABC class - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008708 553.0
TLS2_k127_1894095_10 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.000000000000000000000000000000000000000000004465 166.0
TLS2_k127_1894095_11 COG2335 Secreted and surface protein containing fasciclin-like repeats - - - 0.00000000000000000000000000000000000000000002139 173.0
TLS2_k127_1894095_12 - - - - 0.00000000000000000000000000000000000000002162 161.0
TLS2_k127_1894095_13 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000002859 162.0
TLS2_k127_1894095_14 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000007183 153.0
TLS2_k127_1894095_15 zinc-ribbon family - - - 0.00000000000000000000000001531 119.0
TLS2_k127_1894095_16 transcriptional - GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000004315 101.0
TLS2_k127_1894095_17 Tellurite resistance protein TerB - - - 0.0000000000000000000004333 105.0
TLS2_k127_1894095_18 SpoVT / AbrB like domain K07172 - - 0.000000000000000000791 89.0
TLS2_k127_1894095_19 Family of unknown function (DUF5335) - - - 0.00000000000008417 78.0
TLS2_k127_1894095_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 417.0
TLS2_k127_1894095_20 Phosphoglycerate mutase family - - - 0.0000000000001029 83.0
TLS2_k127_1894095_21 - - - - 0.0000000000001512 77.0
TLS2_k127_1894095_22 Peptidoglycan-binding domain 1 protein - - - 0.0000000004608 65.0
TLS2_k127_1894095_3 Carbon-nitrogen hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 384.0
TLS2_k127_1894095_4 PDZ domain (Also known as DHR K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003078 310.0
TLS2_k127_1894095_5 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000001556 239.0
TLS2_k127_1894095_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002223 229.0
TLS2_k127_1894095_7 cobalamin binding K22491 - - 0.000000000000000000000000000000000000000000000000000000005269 210.0
TLS2_k127_1894095_8 Histidine kinase K07675 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000008712 209.0
TLS2_k127_1894095_9 SdpI/YhfL protein family - - - 0.00000000000000000000000000000000000000000000001414 178.0
TLS2_k127_1898893_0 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006091 503.0
TLS2_k127_1898893_1 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006587 392.0
TLS2_k127_1898893_10 negative regulation of transcription, DNA-templated - - - 0.0000000000000000883 85.0
TLS2_k127_1898893_11 FGGY family of carbohydrate kinases, N-terminal domain K00854,K00862 - 2.7.1.17,2.7.1.215 0.000000001557 70.0
TLS2_k127_1898893_12 snoRNA binding - - - 0.0000003943 54.0
TLS2_k127_1898893_13 VanZ like family - - - 0.000001982 60.0
TLS2_k127_1898893_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001821 269.0
TLS2_k127_1898893_3 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000303 253.0
TLS2_k127_1898893_4 -O-antigen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002917 259.0
TLS2_k127_1898893_5 PFAM Haloacid dehalogenase domain protein hydrolase K01560,K07025 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000001258 238.0
TLS2_k127_1898893_6 carboxylic acid catabolic process - - - 0.00000000000000000000000000000000000000000000000004994 188.0
TLS2_k127_1898893_7 4'-phosphopantetheinyl transferase superfamily K00997,K06133 - 2.7.8.7 0.00000000000000000000000000000000000000000000000007365 186.0
TLS2_k127_1898893_9 - - - - 0.0000000000000000000000002984 115.0
TLS2_k127_1919160_0 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 536.0
TLS2_k127_1919160_1 Domain of unknown function (DUF4976) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 534.0
TLS2_k127_1919160_10 - - - - 0.000000000004661 78.0
TLS2_k127_1919160_2 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007267 491.0
TLS2_k127_1919160_3 Mate efflux family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009137 390.0
TLS2_k127_1919160_4 peptidylprolyl K03772 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000009879 203.0
TLS2_k127_1919160_5 Metal-dependent phosphoesterase K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000000004395 203.0
TLS2_k127_1919160_6 - - - - 0.000000000000000000000000000000000000000000000000002219 194.0
TLS2_k127_1919160_7 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000000000000000003433 124.0
TLS2_k127_1919160_8 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000001615 98.0
TLS2_k127_1926926_0 Sodium:sulfate symporter transmembrane region K14445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 560.0
TLS2_k127_1926926_1 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 519.0
TLS2_k127_1926926_2 PRC-barrel domain - - - 0.000000000000000000000001036 109.0
TLS2_k127_1929623_0 Beta-lactamase - - - 1.609e-195 623.0
TLS2_k127_1929623_1 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009444 616.0
TLS2_k127_1929623_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009404 308.0
TLS2_k127_1929623_11 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008116 331.0
TLS2_k127_1929623_12 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007568 260.0
TLS2_k127_1929623_13 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.000000000000000000000000000000000000000000000000000000000000000000003013 244.0
TLS2_k127_1929623_14 phosphorelay signal transduction system K12132 - 2.7.11.1 0.0000000000000000000000000000000000000004789 171.0
TLS2_k127_1929623_16 TspO/MBR family K05770 - - 0.0000000000000000000000002684 107.0
TLS2_k127_1929623_17 - - - - 0.000000000001284 71.0
TLS2_k127_1929623_18 response regulator - - - 0.00003632 53.0
TLS2_k127_1929623_2 AMP-binding enzyme C-terminal domain K00666,K01897,K18660 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 574.0
TLS2_k127_1929623_3 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005409 516.0
TLS2_k127_1929623_4 ATP-dependent helicase nuclease subunit A K16898 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 535.0
TLS2_k127_1929623_5 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 518.0
TLS2_k127_1929623_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 379.0
TLS2_k127_1929623_7 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14392 GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015233,GO:0015238,GO:0015291,GO:0015293,GO:0015318,GO:0015711,GO:0015718,GO:0015849,GO:0015887,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051184,GO:0051185,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0090482,GO:0098656,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005547 369.0
TLS2_k127_1929623_8 cAMP biosynthetic process K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 377.0
TLS2_k127_1929623_9 heptosyltransferase K02843 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 340.0
TLS2_k127_1945019_0 Domain of unknown function (DUF5118) - - - 2.675e-222 715.0
TLS2_k127_1945019_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000002417 169.0
TLS2_k127_1945019_2 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000001351 157.0
TLS2_k127_1945019_3 Pfam Activator of Hsp90 ATPase - - - 0.000000000000000002887 95.0
TLS2_k127_1945019_4 - - - - 0.0000000007669 71.0
TLS2_k127_1945019_5 efflux transmembrane transporter activity - - - 0.000001013 52.0
TLS2_k127_1945019_6 Gram-negative bacterial TonB protein C-terminal - - - 0.000004268 59.0
TLS2_k127_1958315_0 Aldehyde dehydrogenase family K22187 - - 3.831e-243 759.0
TLS2_k127_1958315_1 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 608.0
TLS2_k127_1958315_10 Outer membrane protein beta-barrel domain - - - 0.000000000000000000000000000000000006855 145.0
TLS2_k127_1958315_11 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000004958 121.0
TLS2_k127_1958315_12 - - - - 0.000000000000000000000004216 111.0
TLS2_k127_1958315_2 Magnesium chelatase, subunit ChlI K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 526.0
TLS2_k127_1958315_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 418.0
TLS2_k127_1958315_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 328.0
TLS2_k127_1958315_5 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001476 289.0
TLS2_k127_1958315_6 smart pdz dhr glgf K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004294 295.0
TLS2_k127_1958315_7 PP-loop domain protein K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003743 262.0
TLS2_k127_1958315_8 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000008921 233.0
TLS2_k127_1958315_9 creatininase K01470,K22232 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000003954 198.0
TLS2_k127_1972658_0 Sortilin, neurotensin receptor 3, - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 558.0
TLS2_k127_1972658_1 Amidohydrolase family K01465,K06015 - 3.5.1.81,3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 518.0
TLS2_k127_1972658_2 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 493.0
TLS2_k127_1972658_3 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 439.0
TLS2_k127_1972658_4 Family of unknown function (DUF1028) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000635 378.0
TLS2_k127_1972658_5 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000004865 216.0
TLS2_k127_1972658_6 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.0000000000000000000000000000000000000000000002726 173.0
TLS2_k127_1972658_7 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000005987 135.0
TLS2_k127_199193_0 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009088 499.0
TLS2_k127_199193_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 446.0
TLS2_k127_199193_10 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007269 279.0
TLS2_k127_199193_11 YceI-like domain - - - 0.000000000000000000000000000000000000000000000000000007798 195.0
TLS2_k127_199193_12 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000004032 176.0
TLS2_k127_199193_13 Protein of unknown function (DUF3299) K09950 - - 0.0000000000000000000000000000000000000000000466 171.0
TLS2_k127_199193_14 to YegS from E. coli K07029 GO:0003674,GO:0003824,GO:0004143,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237 2.7.1.107 0.000000000000000000000000000000000000000002542 169.0
TLS2_k127_199193_15 Belongs to the MraZ family K03925 - - 0.0000000000000000000003502 101.0
TLS2_k127_199193_16 SMART Tetratricopeptide repeat - - - 0.00000521 59.0
TLS2_k127_199193_17 - - - - 0.00000635 55.0
TLS2_k127_199193_2 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 457.0
TLS2_k127_199193_3 Penicillin binding protein transpeptidase domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009197 415.0
TLS2_k127_199193_4 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 388.0
TLS2_k127_199193_5 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 366.0
TLS2_k127_199193_6 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 368.0
TLS2_k127_199193_7 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007023 338.0
TLS2_k127_199193_8 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 309.0
TLS2_k127_199193_9 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 291.0
TLS2_k127_2011905_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.0 1434.0
TLS2_k127_2011905_1 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 589.0
TLS2_k127_2011905_2 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 362.0
TLS2_k127_2011905_3 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 316.0
TLS2_k127_2011905_4 Bacterial transcription activator, effector binding domain K13652 - - 0.00000000000000000000000000000000000000000000000001158 192.0
TLS2_k127_2011905_5 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000705 145.0
TLS2_k127_2011905_6 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000007828 138.0
TLS2_k127_2011905_7 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000001059 127.0
TLS2_k127_2011905_8 Domain of unknown function (DUF4382) - - - 0.000000000000000000002689 104.0
TLS2_k127_2024356_0 Proline racemase K01777 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016855,GO:0018112,GO:0019752,GO:0036361,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0050346,GO:0071704,GO:1901564 5.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 452.0
TLS2_k127_2024356_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008704 356.0
TLS2_k127_2024356_2 COG0277 FAD FMN-containing dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005887 286.0
TLS2_k127_2024356_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000000002265 113.0
TLS2_k127_2024356_4 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000006851 110.0
TLS2_k127_2024356_5 Amidohydrolase family - - - 0.0000009881 50.0
TLS2_k127_2024356_7 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000268 53.0
TLS2_k127_2029274_0 Large extracellular alpha-helical protein K06894 - - 1.87e-257 816.0
TLS2_k127_2029274_1 penicillin binding K05367 - 2.4.1.129 3.944e-254 807.0
TLS2_k127_2029274_2 Mannose-6-phosphate isomerase - - - 0.00000000000000000000000000000000000000000000003277 174.0
TLS2_k127_2029274_3 Nucleotidyltransferase domain K07075 - - 0.0000000000000000000000000000009926 126.0
TLS2_k127_2029274_4 Protein of unknown function DUF86 - - - 0.000000000000000000001884 98.0
TLS2_k127_2029274_5 PFAM YcfA-like protein - - - 0.00003837 49.0
TLS2_k127_2036700_0 ABC transporter K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001195 270.0
TLS2_k127_2036700_1 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000002416 248.0
TLS2_k127_2036700_2 Part of the ABC transporter FtsEX involved in K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000008862 232.0
TLS2_k127_2036700_3 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000004206 238.0
TLS2_k127_2036700_4 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000001347 211.0
TLS2_k127_2036700_5 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000001475 203.0
TLS2_k127_2036700_6 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.000000000000000000000000000000132 128.0
TLS2_k127_2036700_7 Lytic transglycosylase catalytic K08307 - - 0.000000000000000000000000000004838 128.0
TLS2_k127_2036700_8 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03771 - 5.2.1.8 0.000000000000000000000000001575 128.0
TLS2_k127_2036700_9 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.0000000000000000000000001098 123.0
TLS2_k127_2039331_0 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005509 586.0
TLS2_k127_2039331_1 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 478.0
TLS2_k127_2039331_10 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 343.0
TLS2_k127_2039331_11 PFAM extracellular solute-binding protein family 1 K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008475 340.0
TLS2_k127_2039331_12 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 353.0
TLS2_k127_2039331_13 Aminotransferase class-V K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 341.0
TLS2_k127_2039331_14 Lanthionine synthetase C family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007201 332.0
TLS2_k127_2039331_15 Phosphate transport system permease protein PstA K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 326.0
TLS2_k127_2039331_16 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006259 318.0
TLS2_k127_2039331_17 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 298.0
TLS2_k127_2039331_18 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005158 314.0
TLS2_k127_2039331_19 HAMP domain K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000416 297.0
TLS2_k127_2039331_2 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 466.0
TLS2_k127_2039331_20 dTDP biosynthetic process K00560,K00943,K01585 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.1.1.45,2.7.4.9,4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001912 286.0
TLS2_k127_2039331_21 Transcriptional regulatory protein, C terminal K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001433 279.0
TLS2_k127_2039331_22 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001855 265.0
TLS2_k127_2039331_23 dTDP biosynthetic process K00943,K01585 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.9,4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000001284 256.0
TLS2_k127_2039331_24 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000003853 227.0
TLS2_k127_2039331_25 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000006441 214.0
TLS2_k127_2039331_26 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000004895 188.0
TLS2_k127_2039331_27 Protein of unknown function DUF47 K02039,K07220 GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000000000000000000000001688 184.0
TLS2_k127_2039331_28 BlaR1 peptidase M56 - - - 0.00000000000000000000000000000000000000000000009885 192.0
TLS2_k127_2039331_29 Penicillinase repressor - - - 0.00000000000000000000000000000000000000001206 157.0
TLS2_k127_2039331_3 Peptidase, M16 K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 446.0
TLS2_k127_2039331_31 PFAM RDD domain containing protein - - - 0.000000000000000000000000000000000000004953 157.0
TLS2_k127_2039331_32 DUF218 domain - - - 0.000000000000000000000000000000000001694 145.0
TLS2_k127_2039331_33 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000001466 141.0
TLS2_k127_2039331_34 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000002966 137.0
TLS2_k127_2039331_35 DoxX K15977 - - 0.00000000000000000000000000000001207 133.0
TLS2_k127_2039331_36 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000006384 121.0
TLS2_k127_2039331_37 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA K01692 - 4.2.1.17 0.000000000000000000000000004056 122.0
TLS2_k127_2039331_38 Cbs domain - - - 0.0000000000000000000000001295 117.0
TLS2_k127_2039331_39 - - - - 0.000000000000000000000002662 111.0
TLS2_k127_2039331_4 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 461.0
TLS2_k127_2039331_40 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.000000000000000000009449 104.0
TLS2_k127_2039331_41 protoporphyrinogen oxidase activity K00231 - 1.3.3.15,1.3.3.4 0.000000000000000001473 99.0
TLS2_k127_2039331_42 - - - - 0.000000000000000002446 87.0
TLS2_k127_2039331_43 lyase activity - - - 0.00000000006456 75.0
TLS2_k127_2039331_44 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - 0.0000000006754 64.0
TLS2_k127_2039331_45 Zincin-like metallopeptidase K00930 - 2.7.2.8 0.000000007939 68.0
TLS2_k127_2039331_46 PFAM Phosphate-selective porin O K07221 - - 0.00000006158 64.0
TLS2_k127_2039331_47 Putative zinc-finger - - - 0.00000121 59.0
TLS2_k127_2039331_5 mismatched DNA binding K03555 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 439.0
TLS2_k127_2039331_6 metalloenzyme domain protein K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 402.0
TLS2_k127_2039331_7 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008844 372.0
TLS2_k127_2039331_8 polyphosphate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 368.0
TLS2_k127_2039331_9 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 367.0
TLS2_k127_2046495_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 3.387e-240 762.0
TLS2_k127_2046495_1 tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009657 604.0
TLS2_k127_2046495_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002323 442.0
TLS2_k127_2046495_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 344.0
TLS2_k127_2046495_4 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009932 338.0
TLS2_k127_2046495_5 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000145 251.0
TLS2_k127_2046495_6 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000001226 242.0
TLS2_k127_2046495_7 Pyrimidine nucleoside phosphorylase C-terminal domain K00756,K00758 - 2.4.2.2,2.4.2.4 0.000000000000000000000000000003053 125.0
TLS2_k127_2046495_8 HD domain - - - 0.0000000000000000006671 99.0
TLS2_k127_2046495_9 bacterial-type flagellum-dependent cell motility - - - 0.00000000000000002192 94.0
TLS2_k127_2064473_0 2Fe-2S iron-sulfur cluster binding domain K00123 - 1.17.1.9 0.0 1204.0
TLS2_k127_2064473_1 formate dehydrogenase K00122 - 1.17.1.9 8.247e-218 692.0
TLS2_k127_2064473_10 Glycosyltransferase family 9 (heptosyltransferase) K02841,K02843,K02849,K12982 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 377.0
TLS2_k127_2064473_11 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 367.0
TLS2_k127_2064473_12 Glycosyltransferase family 9 (heptosyltransferase) K12982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 353.0
TLS2_k127_2064473_13 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009197 300.0
TLS2_k127_2064473_14 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005411 292.0
TLS2_k127_2064473_15 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006328 295.0
TLS2_k127_2064473_16 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002527 283.0
TLS2_k127_2064473_17 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001246 272.0
TLS2_k127_2064473_18 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008291 276.0
TLS2_k127_2064473_19 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005343 267.0
TLS2_k127_2064473_2 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 625.0
TLS2_k127_2064473_20 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000412 257.0
TLS2_k127_2064473_21 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004713 256.0
TLS2_k127_2064473_22 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000002431 254.0
TLS2_k127_2064473_23 OmpA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000112 258.0
TLS2_k127_2064473_24 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000002411 233.0
TLS2_k127_2064473_25 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000004172 216.0
TLS2_k127_2064473_26 Glycosyl transferase family 2 K08301 - - 0.000000000000000000000000000000000000000000000000000000007198 217.0
TLS2_k127_2064473_27 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000000000000000000000000000000000000000000004465 201.0
TLS2_k127_2064473_28 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000006854 193.0
TLS2_k127_2064473_29 Lipocalin / cytosolic fatty-acid binding protein family K03098 - - 0.00000000000000000000000000000000000000000000000243 181.0
TLS2_k127_2064473_3 PglZ domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000653 536.0
TLS2_k127_2064473_30 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000441 181.0
TLS2_k127_2064473_31 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000000000000000000000000000000000004974 183.0
TLS2_k127_2064473_32 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000000000000000000000000000000001562 170.0
TLS2_k127_2064473_33 glyoxalase III activity - - - 0.00000000000000000000000000000000000000001767 164.0
TLS2_k127_2064473_34 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000005102 148.0
TLS2_k127_2064473_35 Phosphodiester glycosidase - - - 0.0000000000000000000000000000000000003779 155.0
TLS2_k127_2064473_36 Lytic transglycosylase catalytic - - - 0.000000000000000000000000000003437 127.0
TLS2_k127_2064473_37 - - - - 0.0000000000000000000000000001966 127.0
TLS2_k127_2064473_38 PFAM FxsA cytoplasmic membrane protein K07113 - - 0.00000000000000000000000004405 116.0
TLS2_k127_2064473_39 Lipopolysaccharide kinase (Kdo/WaaP) family K11211 - 2.7.1.166 0.00000000000000000000003972 112.0
TLS2_k127_2064473_4 C4-dicarboxylate anaerobic - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004976 516.0
TLS2_k127_2064473_40 Immunoglobulin-like domain of bacterial spore germination - - - 0.0000000000000000001716 96.0
TLS2_k127_2064473_41 AntiSigma factor - GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - 0.00000000000008181 74.0
TLS2_k127_2064473_42 lactoylglutathione lyase activity - - - 0.00001182 53.0
TLS2_k127_2064473_43 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00006632 53.0
TLS2_k127_2064473_5 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 532.0
TLS2_k127_2064473_6 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 509.0
TLS2_k127_2064473_7 ABC transporter transmembrane region K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004345 490.0
TLS2_k127_2064473_8 Pyrrolo-quinoline quinone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 469.0
TLS2_k127_2064473_9 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 392.0
TLS2_k127_207017_0 esterase - - - 4.239e-252 793.0
TLS2_k127_207017_1 peptidase S9B dipeptidylpeptidase IV domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 612.0
TLS2_k127_207017_2 teichoic acid transport K01990,K09689,K09691 - 3.6.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 378.0
TLS2_k127_207017_3 TIGRFAM ornithine aminotransferase K00819 - 2.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000174 282.0
TLS2_k127_207017_4 macromolecule localization K01992,K09690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001418 276.0
TLS2_k127_207017_5 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000000000000000000000000000000000000001161 187.0
TLS2_k127_207017_6 transferase activity, transferring glycosyl groups K01181,K13668 GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.346,3.2.1.8 0.00000000000000000000000000000000000000002691 169.0
TLS2_k127_207017_7 Phospholipase D. Active site motifs. K06131 - - 0.000000000000000000000000000000002725 139.0
TLS2_k127_207017_8 ribosomal rna small subunit methyltransferase K15257 - - 0.00000000000000000000000000000009829 138.0
TLS2_k127_207017_9 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000001077 69.0
TLS2_k127_2083246_0 DNA ligase (ATP) activity K01971 - 6.5.1.1 6.019e-295 930.0
TLS2_k127_2083246_1 efflux transmembrane transporter activity - - - 6.85e-227 733.0
TLS2_k127_2083246_10 DinB superfamily - - - 0.000000000000000000000004653 111.0
TLS2_k127_2083246_12 Transcriptional regulator PadR-like family - - - 0.00000000000000000615 87.0
TLS2_k127_2083246_13 Tricorn protease homolog K08676 - - 0.0000008834 50.0
TLS2_k127_2083246_2 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 2.84e-197 638.0
TLS2_k127_2083246_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 466.0
TLS2_k127_2083246_4 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006676 391.0
TLS2_k127_2083246_5 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 357.0
TLS2_k127_2083246_6 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 306.0
TLS2_k127_2083246_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000008487 246.0
TLS2_k127_2083246_8 - - - - 0.00000000000000000000000000000000000000000000000004111 186.0
TLS2_k127_2083246_9 TPR repeat - - - 0.00000000000000000000000000000000000000000007197 172.0
TLS2_k127_210446_0 Gamma-glutamyltranspeptidase - - - 1.087e-231 739.0
TLS2_k127_210446_1 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 553.0
TLS2_k127_210446_2 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 511.0
TLS2_k127_210446_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 379.0
TLS2_k127_210446_4 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 324.0
TLS2_k127_210446_5 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 304.0
TLS2_k127_210446_6 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000327 280.0
TLS2_k127_210446_7 - - - - 0.00000000000000000000000000000002347 138.0
TLS2_k127_2132519_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 345.0
TLS2_k127_2132519_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 332.0
TLS2_k127_2132519_10 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000003731 164.0
TLS2_k127_2132519_11 Curli production assembly/transport component CsgG - - - 0.000000000000000000000000000000000000227 154.0
TLS2_k127_2132519_13 peptidyl-tyrosine sulfation - - - 0.00000000000000000000002604 114.0
TLS2_k127_2132519_14 Transcriptional regulator PadR-like family - - - 0.000000000000000000001377 98.0
TLS2_k127_2132519_15 - - - - 0.0000000000000001071 81.0
TLS2_k127_2132519_16 Domain of unknown function (DUF4345) - - - 0.00000000000001609 79.0
TLS2_k127_2132519_2 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001688 310.0
TLS2_k127_2132519_3 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000191 248.0
TLS2_k127_2132519_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000009592 225.0
TLS2_k127_2132519_5 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000004195 229.0
TLS2_k127_2132519_6 DinB family - - - 0.0000000000000000000000000000000000000000000000000000002217 199.0
TLS2_k127_2132519_7 Belongs to the UPF0178 family K09768 - - 0.0000000000000000000000000000000000000000000000000001406 192.0
TLS2_k127_2132519_8 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000001257 193.0
TLS2_k127_2132519_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.0000000000000000000000000000000000000000000001165 172.0
TLS2_k127_2140740_0 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 617.0
TLS2_k127_2140740_1 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008313 602.0
TLS2_k127_2140740_2 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000004971 236.0
TLS2_k127_2140740_3 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000006239 108.0
TLS2_k127_2140740_4 COG1404 Subtilisin-like serine proteases K12685,K20754 - 3.4.21.111 0.000000002194 71.0
TLS2_k127_2140740_5 negative regulation of transcription, DNA-templated - - - 0.000003635 50.0
TLS2_k127_2161679_0 Amidohydrolase family - - - 9.177e-293 939.0
TLS2_k127_2161679_1 lysine biosynthetic process via aminoadipic acid - - - 9.22e-252 803.0
TLS2_k127_2161679_10 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008661 396.0
TLS2_k127_2161679_11 ATPases associated with a variety of cellular activities K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 325.0
TLS2_k127_2161679_12 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008891 284.0
TLS2_k127_2161679_13 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.0000000000000000000000000000000000000000000000000000000003946 216.0
TLS2_k127_2161679_14 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000002012 216.0
TLS2_k127_2161679_15 carboxylic acid catabolic process - - - 0.0000000000000000000000000000000000000000000000000000001115 207.0
TLS2_k127_2161679_16 4Fe-4S single cluster domain K07001 - - 0.00000000000000000000000000000000000000000000000007106 191.0
TLS2_k127_2161679_17 NifU-like N terminal domain K04488 - - 0.00000000000000000000000000000000000000001291 158.0
TLS2_k127_2161679_18 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000001128 169.0
TLS2_k127_2161679_19 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000007386 159.0
TLS2_k127_2161679_2 ABC-type transport system involved in Fe-S cluster assembly, permease component K09014 - - 2.211e-227 711.0
TLS2_k127_2161679_20 Rieske-like [2Fe-2S] domain K05710 - - 0.0000000000000000000002067 100.0
TLS2_k127_2161679_21 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000004407 97.0
TLS2_k127_2161679_22 acetyltransferase involved in intracellular survival and related - - - 0.00000000000000005106 91.0
TLS2_k127_2161679_3 Tetratricopeptide repeat - - - 4.168e-198 642.0
TLS2_k127_2161679_4 mannose-ethanolamine phosphotransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006829 574.0
TLS2_k127_2161679_5 Pyridoxal-dependent decarboxylase conserved domain K01593,K01634 - 4.1.1.105,4.1.1.28,4.1.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007592 569.0
TLS2_k127_2161679_6 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003881 490.0
TLS2_k127_2161679_7 UvrD-like helicase C-terminal domain K03656,K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 501.0
TLS2_k127_2161679_8 4Fe-4S binding domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 422.0
TLS2_k127_2161679_9 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 407.0
TLS2_k127_2182558_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 537.0
TLS2_k127_2182558_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 403.0
TLS2_k127_2182558_2 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 377.0
TLS2_k127_2182558_3 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003013 300.0
TLS2_k127_2182558_4 Lumazine binding domain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000003744 180.0
TLS2_k127_2182558_5 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.00000000000000000000000000000000000000000001765 168.0
TLS2_k127_2182558_6 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000005855 98.0
TLS2_k127_2182558_7 PTS system fructose IIA component K02744 - - 0.000000000008764 70.0
TLS2_k127_2182558_8 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.0009967 46.0
TLS2_k127_2194398_0 ADP-glyceromanno-heptose 6-epimerase activity K01710,K01784 - 4.2.1.46,5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 413.0
TLS2_k127_2194398_1 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 379.0
TLS2_k127_2194398_2 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000000000000000000001483 199.0
TLS2_k127_2194398_3 Peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000000000006598 173.0
TLS2_k127_2194398_4 FR47-like protein K18816 - 2.3.1.82 0.00000000000000000000000000006084 121.0
TLS2_k127_2194398_5 TonB-dependent Receptor Plug - - - 0.000000000000000000000426 107.0
TLS2_k127_2246490_0 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005276 409.0
TLS2_k127_2246490_1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008902 370.0
TLS2_k127_2246490_10 - - - - 0.0000000000000000000000000000000000000002292 164.0
TLS2_k127_2246490_11 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.0000000000000000000000000000000000000007903 163.0
TLS2_k127_2246490_12 CheC-like family K03410 - - 0.0000000000000000000000000000000000000517 153.0
TLS2_k127_2246490_13 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000006949 143.0
TLS2_k127_2246490_14 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000001509 145.0
TLS2_k127_2246490_15 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.000000000000000000000000006204 116.0
TLS2_k127_2246490_16 Two component signalling adaptor domain K02659 - - 0.0000000004591 67.0
TLS2_k127_2246490_17 PFAM Roadblock LC7 family protein K07131 GO:0001101,GO:0003674,GO:0005085,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0009719,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0019899,GO:0023051,GO:0023056,GO:0032006,GO:0032008,GO:0032947,GO:0042221,GO:0043200,GO:0044464,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051716,GO:0065007,GO:0065009,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0098772,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 - 0.00000002241 62.0
TLS2_k127_2246490_18 regulation of cell shape K04074,K06997 - - 0.0000000714 66.0
TLS2_k127_2246490_19 Roadblock/LC7 domain - - - 0.000000191 59.0
TLS2_k127_2246490_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 328.0
TLS2_k127_2246490_20 Tetratricopeptide repeats - - - 0.0000002749 63.0
TLS2_k127_2246490_21 Phage integrase family - - - 0.0000007481 61.0
TLS2_k127_2246490_3 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 292.0
TLS2_k127_2246490_4 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009184 300.0
TLS2_k127_2246490_5 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004993 280.0
TLS2_k127_2246490_6 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000002515 250.0
TLS2_k127_2246490_7 protein-glutamate O-methyltransferase activity K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000003188 239.0
TLS2_k127_2246490_8 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000003137 204.0
TLS2_k127_2246490_9 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000000000000000000001443 198.0
TLS2_k127_2303872_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.3 3.073e-256 805.0
TLS2_k127_2303872_1 Insulinase (Peptidase family M16) K07263 - - 5.618e-209 693.0
TLS2_k127_2303872_10 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00824 - 2.6.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005453 297.0
TLS2_k127_2303872_11 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003097 290.0
TLS2_k127_2303872_12 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004223 284.0
TLS2_k127_2303872_13 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000066 299.0
TLS2_k127_2303872_14 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000252 274.0
TLS2_k127_2303872_15 photosystem I assembly BtpA K06971 - - 0.0000000000000000000000000000000000000000000000000000000000000000001578 239.0
TLS2_k127_2303872_16 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000002202 238.0
TLS2_k127_2303872_17 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000000000000000000847 242.0
TLS2_k127_2303872_18 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000002917 182.0
TLS2_k127_2303872_19 Pfam:UPF0118 K03548 - - 0.000000000000000000000000000000000000000000000004455 189.0
TLS2_k127_2303872_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K02887,K03628 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 607.0
TLS2_k127_2303872_20 Ferritin-like domain K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000004428 165.0
TLS2_k127_2303872_21 NUDIX domain - - - 0.00000000000000000000000000000000000000001221 162.0
TLS2_k127_2303872_22 MlaD protein K02067 - - 0.0000000000000000000000000000000000000005429 162.0
TLS2_k127_2303872_23 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000000000000202 160.0
TLS2_k127_2303872_24 Phosphoribosyl transferase domain K07101 - - 0.000000000000000000000000000000000000005238 156.0
TLS2_k127_2303872_25 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000007852 150.0
TLS2_k127_2303872_26 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.00000000000000000000000000000000000005006 153.0
TLS2_k127_2303872_27 negative regulation of transcription, DNA-templated - - - 0.00000000000000002398 86.0
TLS2_k127_2303872_28 Protein of unknown function (DUF721) - - - 0.000000000003264 72.0
TLS2_k127_2303872_29 - - - - 0.00000000009375 73.0
TLS2_k127_2303872_3 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 456.0
TLS2_k127_2303872_30 NHL repeat - - - 0.000000001364 70.0
TLS2_k127_2303872_31 - - - - 0.000000004953 68.0
TLS2_k127_2303872_4 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 457.0
TLS2_k127_2303872_5 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 399.0
TLS2_k127_2303872_6 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 364.0
TLS2_k127_2303872_7 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 385.0
TLS2_k127_2303872_8 Pyridine nucleotide-disulphide oxidoreductase K21567 GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 351.0
TLS2_k127_2303872_9 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 343.0
TLS2_k127_2328848_0 Amidohydrolase family - - - 1.402e-254 821.0
TLS2_k127_2328848_1 PFAM AMP-dependent synthetase and ligase K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006732 512.0
TLS2_k127_2328848_10 - - - - 0.00000000000000002405 87.0
TLS2_k127_2328848_11 regulation of RNA biosynthetic process - - - 0.0000000000000001274 89.0
TLS2_k127_2328848_2 AMP-binding enzyme C-terminal domain K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003753 444.0
TLS2_k127_2328848_3 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 364.0
TLS2_k127_2328848_4 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 286.0
TLS2_k127_2328848_5 Ndr family K00433,K01055 - 1.11.1.10,3.1.1.24 0.0000000000000000000000000000000000000000000000000000000003573 214.0
TLS2_k127_2328848_6 Ndr family K00433,K01055 - 1.11.1.10,3.1.1.24 0.00000000000000000000000000000000000000000000006084 181.0
TLS2_k127_2328848_7 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000002638 168.0
TLS2_k127_2328848_8 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000003113 152.0
TLS2_k127_2328848_9 phosphorelay signal transduction system K12132 - 2.7.11.1 0.000000000000000000000000000000001725 150.0
TLS2_k127_2349166_0 Mo-molybdopterin cofactor metabolic process K03148,K03636,K21029,K21147 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.73,2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 580.0
TLS2_k127_2349166_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 296.0
TLS2_k127_2349166_2 Putative glycosyl hydrolase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 297.0
TLS2_k127_2349166_3 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001326 286.0
TLS2_k127_2349166_4 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000003458 235.0
TLS2_k127_2349166_5 DNA methyltransferase K07318 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000002477 225.0
TLS2_k127_2349166_6 Protein of unknown function (DUF423) - - - 0.000000000000000000000000000000000000003304 157.0
TLS2_k127_2349166_7 JAB/MPN domain K21140 - 3.13.1.6 0.0000000000000025 83.0
TLS2_k127_2349166_8 NHL repeat - - - 0.00003751 55.0
TLS2_k127_2368889_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 482.0
TLS2_k127_2368889_1 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 323.0
TLS2_k127_2368889_2 COG2217 Cation transport ATPase K01534 - 3.6.3.3,3.6.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 308.0
TLS2_k127_2368889_3 Two component transcriptional regulator, LuxR family K07693 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003239 274.0
TLS2_k127_2368889_4 Histidine kinase K07778 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000002403 258.0
TLS2_k127_2368889_5 ABC-2 type transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000002896 242.0
TLS2_k127_2368889_6 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000001593 190.0
TLS2_k127_2368889_8 PFAM formate nitrite transporter K21990 - - 0.00000000000000000000002513 111.0
TLS2_k127_238866_0 TonB-dependent receptor - - - 5.814e-292 932.0
TLS2_k127_238866_1 Prolyl oligopeptidase family - - - 1.674e-246 789.0
TLS2_k127_238866_10 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 363.0
TLS2_k127_238866_11 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 370.0
TLS2_k127_238866_12 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 353.0
TLS2_k127_238866_13 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 323.0
TLS2_k127_238866_14 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 332.0
TLS2_k127_238866_15 PFAM RES domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009625 299.0
TLS2_k127_238866_16 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000125 280.0
TLS2_k127_238866_17 Oxidoreductase family, NAD-binding Rossmann fold K00118,K13020 - 1.1.1.335,1.1.99.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000342 280.0
TLS2_k127_238866_18 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001844 269.0
TLS2_k127_238866_19 - - - - 0.0000000000000000000000000000000000000000000000000000000000000003361 243.0
TLS2_k127_238866_2 Flavin containing amine oxidoreductase - - - 6.644e-222 699.0
TLS2_k127_238866_20 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000001284 230.0
TLS2_k127_238866_21 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000314 222.0
TLS2_k127_238866_22 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000004116 220.0
TLS2_k127_238866_23 - - - - 0.00000000000000000000000000000000000000003009 160.0
TLS2_k127_238866_24 integral membrane protein - - - 0.000000000000000000000000000000000000002143 153.0
TLS2_k127_238866_25 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000001096 141.0
TLS2_k127_238866_26 negative regulation of transcription, DNA-templated - - - 0.00000000000000000002847 94.0
TLS2_k127_238866_27 PFAM cytochrome c, class I - - - 0.0000000000000308 79.0
TLS2_k127_238866_28 Flavin containing amine oxidoreductase - - - 0.000001509 54.0
TLS2_k127_238866_3 TonB-dependent receptor - - - 3.731e-207 681.0
TLS2_k127_238866_4 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 578.0
TLS2_k127_238866_5 metallopeptidase activity K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008575 559.0
TLS2_k127_238866_6 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 483.0
TLS2_k127_238866_7 Cys/Met metabolism PLP-dependent enzyme K01758 GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846 4.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 421.0
TLS2_k127_238866_8 PFAM Peptidoglycan-binding domain 1 protein K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004416 419.0
TLS2_k127_238866_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 362.0
TLS2_k127_2437109_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 2.059e-258 813.0
TLS2_k127_2437109_1 NAD synthase K01916 - 6.3.1.5 8.181e-199 637.0
TLS2_k127_2437109_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000603 483.0
TLS2_k127_2437109_11 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006324 478.0
TLS2_k127_2437109_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 468.0
TLS2_k127_2437109_13 PFAM Uncharacterised protein family UPF0182 K09118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 468.0
TLS2_k127_2437109_14 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007996 443.0
TLS2_k127_2437109_15 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 434.0
TLS2_k127_2437109_16 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000054 425.0
TLS2_k127_2437109_17 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 401.0
TLS2_k127_2437109_18 ABC transporter K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 397.0
TLS2_k127_2437109_19 SIS domain K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 376.0
TLS2_k127_2437109_2 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 613.0
TLS2_k127_2437109_20 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006743 383.0
TLS2_k127_2437109_21 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 377.0
TLS2_k127_2437109_22 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008587 389.0
TLS2_k127_2437109_23 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 349.0
TLS2_k127_2437109_24 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 342.0
TLS2_k127_2437109_25 Fe-S oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 346.0
TLS2_k127_2437109_26 Bacterial membrane protein YfhO - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 350.0
TLS2_k127_2437109_27 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 332.0
TLS2_k127_2437109_28 DAHP synthetase I family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 303.0
TLS2_k127_2437109_29 Acyl transferase domain K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 306.0
TLS2_k127_2437109_3 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003442 598.0
TLS2_k127_2437109_30 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008624 301.0
TLS2_k127_2437109_31 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003088 287.0
TLS2_k127_2437109_32 Amino acid kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001172 280.0
TLS2_k127_2437109_33 with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000002299 263.0
TLS2_k127_2437109_34 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000246 271.0
TLS2_k127_2437109_35 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000003127 273.0
TLS2_k127_2437109_36 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000003463 253.0
TLS2_k127_2437109_37 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000001322 233.0
TLS2_k127_2437109_38 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000004345 233.0
TLS2_k127_2437109_39 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.7 0.000000000000000000000000000000000000000000000000000000009086 203.0
TLS2_k127_2437109_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008879 582.0
TLS2_k127_2437109_40 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000003719 187.0
TLS2_k127_2437109_41 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000005546 184.0
TLS2_k127_2437109_42 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000001351 183.0
TLS2_k127_2437109_43 NDK K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000009739 168.0
TLS2_k127_2437109_44 TPM domain K06872 - - 0.000000000000000000000000000000000000000000003222 176.0
TLS2_k127_2437109_45 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000007436 167.0
TLS2_k127_2437109_46 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000003229 153.0
TLS2_k127_2437109_47 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - 0.0000000000000000000000000000000000000006607 162.0
TLS2_k127_2437109_48 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000003213 163.0
TLS2_k127_2437109_49 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.0000000000000000000000000000000000001807 148.0
TLS2_k127_2437109_5 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 539.0
TLS2_k127_2437109_50 LemA family K03744 - - 0.0000000000000000000000000000000000005311 151.0
TLS2_k127_2437109_51 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000001236 154.0
TLS2_k127_2437109_52 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000165 146.0
TLS2_k127_2437109_53 - - - - 0.0000000000000000000000000000000004746 149.0
TLS2_k127_2437109_54 - - - - 0.0000000000000000000000000000002012 142.0
TLS2_k127_2437109_55 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000002388 139.0
TLS2_k127_2437109_56 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000000000339 125.0
TLS2_k127_2437109_57 SNARE associated Golgi protein - - - 0.0000000000000000000000000000005655 129.0
TLS2_k127_2437109_59 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.000000000000000000000000001182 117.0
TLS2_k127_2437109_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 507.0
TLS2_k127_2437109_60 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000002664 118.0
TLS2_k127_2437109_61 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K06898,K09121 - 4.99.1.12 0.000000000000000000000000009676 115.0
TLS2_k127_2437109_62 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000005641 113.0
TLS2_k127_2437109_63 nucleotidyltransferase activity - - - 0.000000000000000004291 96.0
TLS2_k127_2437109_64 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000003683 70.0
TLS2_k127_2437109_65 PFAM Methyltransferase type 11 - - - 0.0000000000004562 81.0
TLS2_k127_2437109_66 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000001134 70.0
TLS2_k127_2437109_67 PFAM Tetratricopeptide TPR_2 repeat protein - - - 0.000002847 57.0
TLS2_k127_2437109_68 Lipopolysaccharide-assembly, LptC-related - - - 0.00004089 53.0
TLS2_k127_2437109_7 Elongator protein 3, MiaB family, Radical SAM K18285 - 2.5.1.120 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 504.0
TLS2_k127_2437109_8 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000764 501.0
TLS2_k127_2437109_9 Phosphoglucomutase/phosphomannomutase, C-terminal domain K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008864 507.0
TLS2_k127_2479561_0 nuclear chromosome segregation - - - 9.885e-225 740.0
TLS2_k127_2479561_1 lysine biosynthetic process via aminoadipic acid - - - 4.567e-221 709.0
TLS2_k127_2479561_10 Domain of unknown function (DUF4159) - - - 0.0000000000000000000000000000000000000000000000000000005623 205.0
TLS2_k127_2479561_11 Peptidase C14 caspase catalytic subunit p20 - - - 0.000000000000000000000000000000000000000000000009277 190.0
TLS2_k127_2479561_2 Putative glutamine amidotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009171 593.0
TLS2_k127_2479561_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004005 550.0
TLS2_k127_2479561_4 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 443.0
TLS2_k127_2479561_5 Peptidase family M20/M25/M40 K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 422.0
TLS2_k127_2479561_6 Xylose isomerase-like TIM barrel K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004481 339.0
TLS2_k127_2479561_7 Aerotolerance regulator N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 332.0
TLS2_k127_2479561_8 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 300.0
TLS2_k127_2479561_9 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000000004331 214.0
TLS2_k127_2480916_0 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000007144 208.0
TLS2_k127_2480916_1 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000001556 199.0
TLS2_k127_2480916_10 AntiSigma factor - - - 0.000002038 59.0
TLS2_k127_2480916_2 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000005707 193.0
TLS2_k127_2480916_3 PFAM helix-turn-helix- domain containing protein, AraC type - - - 0.0000000000000000000000000000000000000001173 162.0
TLS2_k127_2480916_4 DinB superfamily - - - 0.000000000000000000000000000000000000005229 150.0
TLS2_k127_2480916_5 - - - - 0.00000000000000000000000000000000833 134.0
TLS2_k127_2480916_6 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000008071 132.0
TLS2_k127_2480916_7 DNA-templated transcription, initiation K03088,K07263 - - 0.000000000000000000004837 100.0
TLS2_k127_2480916_8 - - - - 0.0000000000007919 78.0
TLS2_k127_2480916_9 YCII-related domain - - - 0.000000002063 68.0
TLS2_k127_2535804_0 Peptidase family M1 domain - - - 0.0 1124.0
TLS2_k127_2535804_1 antiporter K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007187 397.0
TLS2_k127_2535804_2 Sigma-54 interaction domain K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 373.0
TLS2_k127_2535804_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000001886 239.0
TLS2_k127_2535804_4 Tetratricopeptide repeat K08309 - - 0.00000000000000000000000000000000000000000000000006551 201.0
TLS2_k127_2535804_5 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000131 138.0
TLS2_k127_2535804_6 OmpA family K03640 - - 0.000000000000000000000000000001715 133.0
TLS2_k127_2535804_7 amine dehydrogenase activity - - - 0.00000000000001278 87.0
TLS2_k127_2535804_8 NHL repeat K11997,K12035 GO:0003008,GO:0003012,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007610,GO:0007626,GO:0008150,GO:0008152,GO:0008270,GO:0008345,GO:0009653,GO:0009987,GO:0010927,GO:0016043,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030239,GO:0030537,GO:0031032,GO:0031674,GO:0032446,GO:0032501,GO:0032502,GO:0032989,GO:0036211,GO:0042592,GO:0042692,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044464,GO:0046716,GO:0046872,GO:0046914,GO:0048468,GO:0048646,GO:0048747,GO:0048856,GO:0048869,GO:0051146,GO:0055001,GO:0055002,GO:0060249,GO:0061061,GO:0065007,GO:0065008,GO:0070647,GO:0070925,GO:0071704,GO:0071840,GO:0097435,GO:0099080,GO:0099081,GO:0099512,GO:0140096,GO:1901564 2.3.2.27 0.00003355 56.0
TLS2_k127_2583083_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 3.787e-213 680.0
TLS2_k127_2583083_1 B3/4 domain K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 580.0
TLS2_k127_2583083_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 370.0
TLS2_k127_2583083_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000003747 223.0
TLS2_k127_2583083_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000002832 140.0
TLS2_k127_2583083_5 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000003202 73.0
TLS2_k127_2630321_0 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 579.0
TLS2_k127_2630321_1 protein histidine kinase activity K03407,K07678 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008939 529.0
TLS2_k127_2630321_2 A G-specific adenine glycosylase K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 295.0
TLS2_k127_2630321_3 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.000000000000000000000000000000578 125.0
TLS2_k127_2630321_4 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure - - - 0.00000000000000000000000000002626 122.0
TLS2_k127_2630321_5 Gas vesicle - - - 0.000000000000000000000000004163 124.0
TLS2_k127_2630321_7 Gas vesicle synthesis protein GvpL/GvpF - - - 0.000000000000001822 86.0
TLS2_k127_2630321_8 Gas vesicle - - - 0.000000000000008384 84.0
TLS2_k127_2630321_9 gas vesicle protein - - - 0.000000001376 64.0
TLS2_k127_2665232_0 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 564.0
TLS2_k127_2665232_1 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 511.0
TLS2_k127_2665232_10 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000000000000000000000000001441 147.0
TLS2_k127_2665232_11 Protein of unknown function (DUF2384) - - - 0.000000000000000000005283 98.0
TLS2_k127_2665232_12 RES - - - 0.00000000000000001523 89.0
TLS2_k127_2665232_2 Tetratricopeptide TPR_2 repeat protein K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004819 465.0
TLS2_k127_2665232_3 oxidoreductase activity K00274 - 1.4.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 332.0
TLS2_k127_2665232_4 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000351 337.0
TLS2_k127_2665232_5 multidrug K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001727 297.0
TLS2_k127_2665232_6 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003091 297.0
TLS2_k127_2665232_7 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000026 261.0
TLS2_k127_2665232_8 Pro-kumamolisin, activation domain K05998 - 3.4.21.100 0.0000000000000000000000000000000000000000000000000000000000000000000001103 269.0
TLS2_k127_2665232_9 PFAM Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000003914 194.0
TLS2_k127_2706289_0 Aldehyde dehydrogenase family K02618,K15514 - 1.2.1.77,1.2.1.91,3.3.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 497.0
TLS2_k127_2706289_1 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000054 493.0
TLS2_k127_2706289_10 Domain of unknown function (DUF4249) - - - 0.0002093 53.0
TLS2_k127_2706289_2 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 351.0
TLS2_k127_2706289_3 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 315.0
TLS2_k127_2706289_4 Predicted methyltransferase regulatory domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003196 316.0
TLS2_k127_2706289_5 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000213 265.0
TLS2_k127_2706289_6 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000001424 202.0
TLS2_k127_2706289_7 TonB dependent receptor - - - 0.00000000000000000000000006929 119.0
TLS2_k127_2706289_8 Transcriptional regulator PadR-like family - - - 0.00000000000000008932 83.0
TLS2_k127_2706289_9 - - - - 0.000001312 55.0
TLS2_k127_2728547_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003763 575.0
TLS2_k127_2728547_1 CoA binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 491.0
TLS2_k127_2728547_10 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000168 274.0
TLS2_k127_2728547_11 Sigma-70, region 4 K02405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003982 256.0
TLS2_k127_2728547_12 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001142 250.0
TLS2_k127_2728547_13 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000002421 241.0
TLS2_k127_2728547_14 Domain present in phytochromes and cGMP-specific phosphodiesterases. K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000002473 228.0
TLS2_k127_2728547_15 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000001132 138.0
TLS2_k127_2728547_16 Phosphodiester glycosidase - - - 0.00000000000000000000000000105 128.0
TLS2_k127_2728547_17 efflux transmembrane transporter activity K12340 - - 0.0000000000000000003388 101.0
TLS2_k127_2728547_18 Protein of unknown function (DUF454) K09790 - - 0.00000000000000002221 89.0
TLS2_k127_2728547_19 Global regulator protein family K03563 - - 0.000000000000002292 79.0
TLS2_k127_2728547_2 Rieske (2fe-2S) K00499 - 1.14.15.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 463.0
TLS2_k127_2728547_3 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000399 403.0
TLS2_k127_2728547_4 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005003 404.0
TLS2_k127_2728547_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 359.0
TLS2_k127_2728547_6 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 351.0
TLS2_k127_2728547_7 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 340.0
TLS2_k127_2728547_8 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 307.0
TLS2_k127_2728547_9 Secretion protein K01993 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008488 298.0
TLS2_k127_2736466_0 response regulator K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 486.0
TLS2_k127_2736466_1 histidine kinase, HAMP - - - 0.0000000000000000000000000000000000000000000000000000000000000002302 237.0
TLS2_k127_2736466_2 - - - - 0.00000015 64.0
TLS2_k127_2796342_0 GMC oxidoreductase - - - 1.651e-256 801.0
TLS2_k127_2796342_1 GMC oxidoreductase - - - 2.519e-223 709.0
TLS2_k127_2796342_10 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007462 348.0
TLS2_k127_2796342_11 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002804 280.0
TLS2_k127_2796342_12 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002672 274.0
TLS2_k127_2796342_13 N-acetylglucosaminylinositol deacetylase activity K22135 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001455 251.0
TLS2_k127_2796342_14 Gluconate 2-dehydrogenase subunit 3 - - - 0.000000000000000000000000000000000000000000000000000000000003887 213.0
TLS2_k127_2796342_15 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000005067 213.0
TLS2_k127_2796342_16 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000001189 197.0
TLS2_k127_2796342_17 PFAM metallophosphoesterase - - - 0.00000000000000000000000000000000000000000107 173.0
TLS2_k127_2796342_18 NmrA-like family K19267 - 1.6.5.2 0.000000000000000000000000000000000000001667 158.0
TLS2_k127_2796342_19 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000005993 169.0
TLS2_k127_2796342_2 Peptidase dimerisation domain - - - 3.661e-210 668.0
TLS2_k127_2796342_20 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000001248 151.0
TLS2_k127_2796342_21 - - - - 0.00000000000000000000000000000000000003577 144.0
TLS2_k127_2796342_22 Domain of unknown function (DUF4186) - - - 0.000000000000000000000000000000004634 137.0
TLS2_k127_2796342_23 PIN domain - - - 0.00000000000000000000000000000009443 133.0
TLS2_k127_2796342_24 Gluconate 2-dehydrogenase subunit 3 - - - 0.000000000000000000000000004404 118.0
TLS2_k127_2796342_25 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000003253 112.0
TLS2_k127_2796342_26 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0000000000000000000005913 97.0
TLS2_k127_2796342_27 F420H(2)-dependent quinone reductase - - - 0.0000000000000002086 89.0
TLS2_k127_2796342_28 - - - - 0.000000000000443 79.0
TLS2_k127_2796342_29 Transcriptional regulator PadR-like family - - - 0.000000000001375 72.0
TLS2_k127_2796342_3 Domain of unknown function (DUF5117) - - - 4.838e-195 638.0
TLS2_k127_2796342_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008038 621.0
TLS2_k127_2796342_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005047 584.0
TLS2_k127_2796342_6 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 563.0
TLS2_k127_2796342_7 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 562.0
TLS2_k127_2796342_8 Nucleoside H+ symporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 468.0
TLS2_k127_2796342_9 Peptidase dimerisation domain K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 421.0
TLS2_k127_2848563_0 RecQ zinc-binding K03654 - 3.6.4.12 3.255e-202 642.0
TLS2_k127_2848563_1 ABC transporter transmembrane region K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004287 439.0
TLS2_k127_2848563_10 Transposase mutator type - - - 0.0000000000000000000007317 98.0
TLS2_k127_2848563_11 Transposase zinc-binding domain - - - 0.0000000000000000001118 99.0
TLS2_k127_2848563_12 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000001616 86.0
TLS2_k127_2848563_13 - - - - 0.00000001577 66.0
TLS2_k127_2848563_14 Transposase - - - 0.0000000495 62.0
TLS2_k127_2848563_15 Acetyltransferase (GNAT) family - - - 0.0001504 52.0
TLS2_k127_2848563_2 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 335.0
TLS2_k127_2848563_3 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 320.0
TLS2_k127_2848563_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007893 305.0
TLS2_k127_2848563_5 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000001151 267.0
TLS2_k127_2848563_6 cytochrome c oxidase K02351,K02862 - - 0.000000000000000000000000000000000000000000000000000102 199.0
TLS2_k127_2848563_7 SCO1 SenC K07152 - - 0.0000000000000000000000000000000000000000006092 165.0
TLS2_k127_2848563_8 Belongs to the UPF0403 family - - - 0.00000000000000000000000000000000000000002652 158.0
TLS2_k127_2848563_9 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.00000000000000000000000000001114 127.0
TLS2_k127_2852247_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1041.0
TLS2_k127_2852247_1 Zinc carboxypeptidase - - - 0.0 1031.0
TLS2_k127_2852247_10 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000000000000002716 222.0
TLS2_k127_2852247_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K18306 - - 0.000000000000000000000000000005948 133.0
TLS2_k127_2852247_12 DinB superfamily - - - 0.0000000000000000000000001795 113.0
TLS2_k127_2852247_13 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000001833 105.0
TLS2_k127_2852247_14 - - - - 0.0000000000000000000003173 111.0
TLS2_k127_2852247_15 negative regulation of transcription, DNA-templated - - - 0.00000000000000000001258 99.0
TLS2_k127_2852247_16 phosphorelay signal transduction system - - - 0.0000000000000000001125 91.0
TLS2_k127_2852247_17 negative regulation of transcription, DNA-templated - - - 0.0000000000000000134 86.0
TLS2_k127_2852247_18 - - - - 0.0000000000001618 83.0
TLS2_k127_2852247_19 TonB dependent receptor - - - 0.00000002022 66.0
TLS2_k127_2852247_2 Zinc carboxypeptidase - - - 6.684e-291 920.0
TLS2_k127_2852247_3 Amidohydrolase family K06015 - 3.5.1.81 9.537e-243 765.0
TLS2_k127_2852247_4 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006045 437.0
TLS2_k127_2852247_5 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005637 426.0
TLS2_k127_2852247_6 Domain of unknown function (DUF4105) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 314.0
TLS2_k127_2852247_7 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000569 305.0
TLS2_k127_2852247_8 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000008342 231.0
TLS2_k127_2852247_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000005399 238.0
TLS2_k127_2854669_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 3.027e-319 1004.0
TLS2_k127_2854669_1 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 367.0
TLS2_k127_2854669_10 Acetyltransferase, gnat family - - - 0.000000000000002363 89.0
TLS2_k127_2854669_11 MacB-like periplasmic core domain - - - 0.000000000000004698 88.0
TLS2_k127_2854669_12 efflux transmembrane transporter activity K02004 - - 0.00000000000003289 79.0
TLS2_k127_2854669_13 efflux transmembrane transporter activity - - - 0.00000009159 60.0
TLS2_k127_2854669_2 COG1226 Kef-type K transport systems K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004939 297.0
TLS2_k127_2854669_3 YceI-like domain - - - 0.00000000000000000000000000000000000000000001721 169.0
TLS2_k127_2854669_4 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000001881 146.0
TLS2_k127_2854669_5 choline dehydrogenase activity - - - 0.000000000000000000000000000000304 126.0
TLS2_k127_2854669_6 - - - - 0.0000000000000000000000000003249 116.0
TLS2_k127_2854669_8 efflux transmembrane transporter activity - - - 0.0000000000000000000002959 100.0
TLS2_k127_2854669_9 acetyltransferase K17840 - 2.3.1.59 0.000000000000000002277 91.0
TLS2_k127_2948471_0 PFAM Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 540.0
TLS2_k127_2948471_1 glutamate-cysteine ligase activity K00836 - 2.6.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 533.0
TLS2_k127_2948471_10 - - - - 0.0000000002476 67.0
TLS2_k127_2948471_11 SMP-30/Gluconolaconase/LRE-like region - - - 0.00000003337 66.0
TLS2_k127_2948471_2 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 516.0
TLS2_k127_2948471_3 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 461.0
TLS2_k127_2948471_4 ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 429.0
TLS2_k127_2948471_5 esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 306.0
TLS2_k127_2948471_6 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003586 266.0
TLS2_k127_2948471_7 Putative esterase K07017 - - 0.000000000000000000000000000000000000000000000000000000000000000000002477 245.0
TLS2_k127_2948471_8 diguanylate cyclase - - - 0.0000000000000000000000000004749 125.0
TLS2_k127_2948471_9 ADP binding K08282 - 2.7.11.1 0.000000000004279 79.0
TLS2_k127_2951140_0 Involved in the tonB-independent uptake of proteins - - - 5.745e-225 740.0
TLS2_k127_2951140_1 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 637.0
TLS2_k127_2951140_2 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000002672 252.0
TLS2_k127_2951140_3 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000002701 135.0
TLS2_k127_2951140_4 Sporulation related domain - - - 0.000000005132 68.0
TLS2_k127_2956110_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 7.616e-200 629.0
TLS2_k127_2956110_1 mechanosensitive ion channel K16053 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005556 403.0
TLS2_k127_2956110_2 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 327.0
TLS2_k127_2956110_3 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000002472 229.0
TLS2_k127_2956110_4 - - - - 0.00000000000000000000000000001693 129.0
TLS2_k127_2964724_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 552.0
TLS2_k127_2964724_1 PFAM DSBA-like thioredoxin domain - - - 0.000000000000000000000008063 111.0
TLS2_k127_2964724_2 VKc - - - 0.0000000000000005878 83.0
TLS2_k127_2964724_3 Binds to RNA in loop regions with AU-rich sequences K22469 - - 0.0007219 50.0
TLS2_k127_296826_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 9.593e-318 987.0
TLS2_k127_296826_1 TonB-dependent Receptor Plug Domain K02014 - - 1.198e-214 688.0
TLS2_k127_296826_2 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002104 262.0
TLS2_k127_296826_3 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000001893 254.0
TLS2_k127_296826_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005469 258.0
TLS2_k127_296826_5 Uncharacterized conserved protein (COG2071) K09166 - - 0.000000000000000000000000000000000000000000000000000000000000000000003395 244.0
TLS2_k127_2983840_0 Domain of unknown function (DUF5117) - - - 1.356e-275 874.0
TLS2_k127_2983840_1 Carboxyl transferase domain - - - 9.155e-245 768.0
TLS2_k127_2983840_10 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000009819 187.0
TLS2_k127_2983840_11 Belongs to the enoyl-CoA hydratase isomerase family K13766 - 4.2.1.18 0.0000000000000000000000000000000000000000000001705 179.0
TLS2_k127_2983840_12 - - - - 0.000000000000000000000000000000000001214 151.0
TLS2_k127_2983840_13 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000004938 115.0
TLS2_k127_2983840_14 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000005528 82.0
TLS2_k127_2983840_2 Methylmalonyl-CoA mutase K01848,K11942 - 5.4.99.13,5.4.99.2 7.383e-236 740.0
TLS2_k127_2983840_3 Acyclic terpene utilisation family protein AtuA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 609.0
TLS2_k127_2983840_4 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 497.0
TLS2_k127_2983840_5 RecQ zinc-binding K03654 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 440.0
TLS2_k127_2983840_6 Ribonuclease E/G family K08300,K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008266 427.0
TLS2_k127_2983840_7 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 358.0
TLS2_k127_2983840_8 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003983 326.0
TLS2_k127_2983840_9 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000001841 212.0
TLS2_k127_3017809_0 serine-type peptidase activity K01278 - 3.4.14.5 2.587e-281 882.0
TLS2_k127_3017809_1 Bacterial protein of unknown function (DUF885) - - - 5.162e-200 640.0
TLS2_k127_3017809_10 - - - - 0.00003125 52.0
TLS2_k127_3017809_2 neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 387.0
TLS2_k127_3017809_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007083 286.0
TLS2_k127_3017809_4 Belongs to the pseudouridine synthase RsuA family K06178 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000794 243.0
TLS2_k127_3017809_5 MafB19-like deaminase K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000000000000004415 235.0
TLS2_k127_3017809_6 Protein of unknown function (DUF1569) - - - 0.0000000000000000000000000000000000001914 149.0
TLS2_k127_3017809_7 Gamma-glutamyltransferase - - - 0.000000000000000000000000000007828 128.0
TLS2_k127_3017809_8 - - - - 0.00000000000000000000000002058 121.0
TLS2_k127_3017809_9 Chlorophyllase enzyme - - - 0.00000000000000000000000004619 113.0
TLS2_k127_302906_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 0.0 1727.0
TLS2_k127_302906_1 cellulose binding - - - 1.205e-271 873.0
TLS2_k127_302906_10 aminoglycoside hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.00000000000000000000000000000001136 139.0
TLS2_k127_302906_11 cyclic nucleotide binding K10914,K21563 - - 0.00000000000000000000000000000366 131.0
TLS2_k127_302906_12 DNA-templated transcription, initiation K02405 - - 0.0000000000000000000000004548 113.0
TLS2_k127_302906_13 Alpha beta hydrolase K00433 - 1.11.1.10 0.000000006679 63.0
TLS2_k127_302906_14 WD-40 repeat - - - 0.00000005611 67.0
TLS2_k127_302906_15 Cupin 2, conserved barrel domain protein - - - 0.0000009689 59.0
TLS2_k127_302906_2 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 572.0
TLS2_k127_302906_3 Bacterial protein of unknown function (DUF885) K01322 - 3.4.21.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 507.0
TLS2_k127_302906_4 transmembrane transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007668 342.0
TLS2_k127_302906_5 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002912 296.0
TLS2_k127_302906_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000319 243.0
TLS2_k127_302906_7 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000002411 207.0
TLS2_k127_302906_8 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) K08680 - 4.2.99.20 0.0000000000000000000000000000000000000000477 163.0
TLS2_k127_302906_9 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000002803 162.0
TLS2_k127_3033790_0 transposition - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 385.0
TLS2_k127_3033790_1 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 374.0
TLS2_k127_3033790_10 transposase activity K07483,K07497 - - 0.0000000000000596 72.0
TLS2_k127_3033790_11 Transposase zinc-binding domain - - - 0.000000002217 63.0
TLS2_k127_3033790_12 transposase activity K07483,K07497 - - 0.000000002415 60.0
TLS2_k127_3033790_2 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 374.0
TLS2_k127_3033790_3 ATPase activity K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003024 270.0
TLS2_k127_3033790_4 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000004708 243.0
TLS2_k127_3033790_5 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000002164 253.0
TLS2_k127_3033790_6 transmembrane transport K01992 - - 0.000000000000000000000000000000000000000000000000000000005126 217.0
TLS2_k127_3033790_7 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000000001514 150.0
TLS2_k127_3033790_8 Bacterial Ig-like domain 2 - - - 0.00000000000000000000000000000000000001532 161.0
TLS2_k127_3033790_9 Domain of unknown function (DUF4114) - - - 0.000000000000000000009001 100.0
TLS2_k127_305619_0 4Fe-4S dicluster domain K00184 - - 1.539e-222 725.0
TLS2_k127_305619_1 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 556.0
TLS2_k127_305619_10 PFAM AMP-dependent synthetase and ligase K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006405 303.0
TLS2_k127_305619_11 PFAM Fatty acid desaturase K04712 - 1.14.18.5,1.14.19.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002375 276.0
TLS2_k127_305619_12 Acyl-CoA reductase (LuxC) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005882 277.0
TLS2_k127_305619_13 protein histidine kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009013 258.0
TLS2_k127_305619_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001877 255.0
TLS2_k127_305619_15 DNA-templated transcription, initiation - - - 0.0000000000000000000000000000000000000000000000000000000000000004713 232.0
TLS2_k127_305619_16 Pfam Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000004085 227.0
TLS2_k127_305619_17 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000005925 224.0
TLS2_k127_305619_18 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000003439 206.0
TLS2_k127_305619_19 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000000000001467 211.0
TLS2_k127_305619_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 537.0
TLS2_k127_305619_20 - - - - 0.000000000000000000000000000000000000000000002127 175.0
TLS2_k127_305619_21 Tetratricopeptide repeat K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000008463 162.0
TLS2_k127_305619_22 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000002823 162.0
TLS2_k127_305619_23 Peptidase M14, carboxypeptidase A - - - 0.00000000000000000000000000000000000001084 164.0
TLS2_k127_305619_24 Histidine kinase - - - 0.00000000000000000000000000000000004335 147.0
TLS2_k127_305619_25 PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000002406 151.0
TLS2_k127_305619_26 Protein of unknown function (DUF3341) - - - 0.0000000000000000000000000000000004101 146.0
TLS2_k127_305619_27 - - - - 0.000000000000000000000000000000002394 140.0
TLS2_k127_305619_28 transglycosylase associated protein - - - 0.0000000000000000000000000000005428 123.0
TLS2_k127_305619_29 lytic transglycosylase activity - - - 0.0000000000000000007366 96.0
TLS2_k127_305619_3 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008204 509.0
TLS2_k127_305619_30 cytochrome c - - - 0.000000000000000003991 94.0
TLS2_k127_305619_31 - - - - 0.0000000000000007751 85.0
TLS2_k127_305619_33 SnoaL-like domain - - - 0.00001389 54.0
TLS2_k127_305619_34 Tetratricopeptide repeat - - - 0.0004146 52.0
TLS2_k127_305619_4 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005775 482.0
TLS2_k127_305619_5 Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 475.0
TLS2_k127_305619_6 iron assimilation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 435.0
TLS2_k127_305619_7 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003715 407.0
TLS2_k127_305619_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 331.0
TLS2_k127_305619_9 photoreceptor activity K02484 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 321.0
TLS2_k127_317287_0 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 542.0
TLS2_k127_317287_1 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 500.0
TLS2_k127_317287_2 SERine Proteinase INhibitors K13963 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006852 345.0
TLS2_k127_317287_3 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000001408 227.0
TLS2_k127_317287_4 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000001102 162.0
TLS2_k127_317287_5 Transcriptional regulator PadR-like family - - - 0.000000000000000000000008645 104.0
TLS2_k127_3239890_0 Tricorn protease C1 domain K08676 - - 0.0 1212.0
TLS2_k127_3239890_1 TonB dependent receptor - - - 0.0 1032.0
TLS2_k127_3239890_10 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 431.0
TLS2_k127_3239890_11 FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004446 338.0
TLS2_k127_3239890_12 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 332.0
TLS2_k127_3239890_13 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008218 322.0
TLS2_k127_3239890_14 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004478 279.0
TLS2_k127_3239890_15 rubredoxin K22405 - 1.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000006529 279.0
TLS2_k127_3239890_16 Macrocin-O-methyltransferase (TylF) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005351 257.0
TLS2_k127_3239890_17 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000006586 243.0
TLS2_k127_3239890_18 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000003255 232.0
TLS2_k127_3239890_19 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000000000000031 206.0
TLS2_k127_3239890_2 Protein conserved in bacteria - - - 1.7e-230 730.0
TLS2_k127_3239890_20 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000001597 204.0
TLS2_k127_3239890_21 protein tyrosine kinase activity K03593 - - 0.000000000000000000000000000000000000000000000000002422 194.0
TLS2_k127_3239890_22 peroxidase activity K09162 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 0.00000000000000000000000000000000000000000000000003352 187.0
TLS2_k127_3239890_23 carboxylic acid catabolic process - - - 0.00000000000000000000000000000000000000000000004118 180.0
TLS2_k127_3239890_24 Cytochrome c oxidase, subunit III K02276,K02299 - 1.9.3.1 0.00000000000000000000000000000000000000227 154.0
TLS2_k127_3239890_25 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.0000000000000000000000000000000008249 143.0
TLS2_k127_3239890_26 - - - - 0.0000000000000000000000132 112.0
TLS2_k127_3239890_27 Proto-chlorophyllide reductase 57 kd subunit - - - 0.0000000000000000000003227 109.0
TLS2_k127_3239890_28 Transcriptional regulator PadR-like family - - - 0.0000000000000001909 84.0
TLS2_k127_3239890_29 HmuY protein - - - 0.000000000000000443 87.0
TLS2_k127_3239890_3 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.454e-208 664.0
TLS2_k127_3239890_30 negative regulation of transcription, DNA-templated - - - 0.0000000000000008637 82.0
TLS2_k127_3239890_31 4Fe-4S single cluster domain of Ferredoxin I - - - 0.0000000000001164 79.0
TLS2_k127_3239890_32 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K02297 - 1.10.3.10,1.9.3.1 0.0000000000003183 79.0
TLS2_k127_3239890_33 - - - - 0.00000001881 67.0
TLS2_k127_3239890_4 Domain of unknown function (DUF3471) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 589.0
TLS2_k127_3239890_5 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 589.0
TLS2_k127_3239890_6 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003288 547.0
TLS2_k127_3239890_7 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 498.0
TLS2_k127_3239890_8 chaperone-mediated protein folding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 479.0
TLS2_k127_3239890_9 SusD family K21572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 445.0
TLS2_k127_3269288_0 Domain of unknown function DUF87 - - - 1.189e-278 881.0
TLS2_k127_3269288_1 MacB-like periplasmic core domain K02004 - - 1.538e-236 761.0
TLS2_k127_3269288_2 Zinc carboxypeptidase - - - 6.854e-213 692.0
TLS2_k127_3269288_3 Amidohydrolase family K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008002 558.0
TLS2_k127_3269288_4 Lipocalin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 450.0
TLS2_k127_3269288_5 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 294.0
TLS2_k127_3269288_6 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006459 275.0
TLS2_k127_3269288_7 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000004039 226.0
TLS2_k127_3269288_8 TIGRFAM DNA binding domain protein, excisionase family K22491 - - 0.00000000000000000000000000000000000000000000000000000003096 208.0
TLS2_k127_3300505_0 TIGRFAM DNA polymerase III, alpha subunit K02337,K14162 - 2.7.7.7 7.08e-301 961.0
TLS2_k127_3300505_1 Elongation factor G C-terminus K06207 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 440.0
TLS2_k127_3300505_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008864 370.0
TLS2_k127_3300505_3 cation diffusion facilitator family transporter K16264 GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001474 276.0
TLS2_k127_3300505_4 Glycosyl hydrolase family 65 central catalytic domain K01194 - 3.2.1.28 0.000000000000000000000000000000000000000000000002717 187.0
TLS2_k127_3300505_5 Domain of unknown function (DUF4837) - - - 0.00000135 60.0
TLS2_k127_331658_0 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006079 587.0
TLS2_k127_331658_1 Anthranilate synthase component I, N terminal region K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 521.0
TLS2_k127_331658_10 Abc transporter K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000003968 228.0
TLS2_k127_331658_11 Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000002335 160.0
TLS2_k127_331658_12 Diphthamide synthase - - - 0.0000000000000000000000000000000000000493 153.0
TLS2_k127_331658_13 EamA-like transporter family - - - 0.000000000000000000000000000000000001149 151.0
TLS2_k127_331658_14 Flavin reductase like domain K16048 - - 0.000000000000000000000000000000000006431 143.0
TLS2_k127_331658_15 Alcohol dehydrogenase zinc-binding domain protein - - - 0.000000000000000000000000000000006089 135.0
TLS2_k127_331658_16 Transcriptional regulator padr family - - - 0.00000000009615 68.0
TLS2_k127_331658_2 Protein of unknown function (DUF2723) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 461.0
TLS2_k127_331658_3 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 421.0
TLS2_k127_331658_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 357.0
TLS2_k127_331658_5 8-amino-7-oxononanoate synthase activity K00639,K00652 - 2.3.1.29,2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005702 359.0
TLS2_k127_331658_6 FecCD transport family K02013,K02015 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 304.0
TLS2_k127_331658_7 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 319.0
TLS2_k127_331658_8 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002109 287.0
TLS2_k127_331658_9 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000002751 244.0
TLS2_k127_3325325_0 Amidohydrolase family K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 430.0
TLS2_k127_3325325_1 AAA ATPase domain - - - 0.000000000000000000000000000000000006115 159.0
TLS2_k127_3325325_2 Membrane - - - 0.00000004778 64.0
TLS2_k127_3325325_3 Periplasmic component of the Tol biopolymer transport system - - - 0.00008186 57.0
TLS2_k127_3411298_0 protein conserved in bacteria - - - 4.972e-234 740.0
TLS2_k127_3411298_1 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 527.0
TLS2_k127_3411298_10 Evidence 2b Function of strongly homologous gene - - - 0.0000000000000000000000000000001122 137.0
TLS2_k127_3411298_11 serine-type peptidase activity K01990,K08884,K12132,K18912 - 1.14.99.50,2.7.11.1 0.000000000000000000000000000005656 127.0
TLS2_k127_3411298_12 - - - - 0.0000000000000000000001019 105.0
TLS2_k127_3411298_13 - - - - 0.000000000000000002192 96.0
TLS2_k127_3411298_14 RES - - - 0.00000000000000006979 89.0
TLS2_k127_3411298_15 PIN domain - - - 0.000000002405 64.0
TLS2_k127_3411298_16 Pentapeptide repeats (9 copies) - - - 0.0005497 54.0
TLS2_k127_3411298_2 Conjugal transfer protein TraG K03205 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 421.0
TLS2_k127_3411298_3 amino acid K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 309.0
TLS2_k127_3411298_4 pfam abc K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 299.0
TLS2_k127_3411298_5 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004953 253.0
TLS2_k127_3411298_6 PFAM Branched-chain amino acid transport system permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000008192 242.0
TLS2_k127_3411298_7 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000002018 235.0
TLS2_k127_3411298_8 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000002929 225.0
TLS2_k127_3411298_9 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000004201 150.0
TLS2_k127_347956_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 9.254e-294 918.0
TLS2_k127_347956_1 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 1.142e-280 880.0
TLS2_k127_347956_10 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 324.0
TLS2_k127_347956_11 Glycosyl hydrolase family 3 N terminal domain K05349 - 3.2.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000552 335.0
TLS2_k127_347956_12 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K07106,K09001 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 2.7.1.170,4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008544 322.0
TLS2_k127_347956_13 Mechanosensitive ion channel K03442 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003176 299.0
TLS2_k127_347956_14 DHH family K06881 - 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002597 281.0
TLS2_k127_347956_15 Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000001353 261.0
TLS2_k127_347956_16 Domain of Unknown Function (DUF1206) - - - 0.0000000000000000000000000000000000000000000000000000000000000003476 233.0
TLS2_k127_347956_17 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000000000000000000000000000000521 228.0
TLS2_k127_347956_18 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000007691 188.0
TLS2_k127_347956_19 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000002543 162.0
TLS2_k127_347956_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 1.259e-256 803.0
TLS2_k127_347956_20 PHP-associated - - - 0.00000000000000000000000000000000000000211 155.0
TLS2_k127_347956_21 Ferric uptake regulator family K03711 - - 0.0000000000000000000000000000000000003033 145.0
TLS2_k127_347956_22 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000002643 147.0
TLS2_k127_347956_23 - - - - 0.000000000000000000000000000000252 134.0
TLS2_k127_347956_24 SNARE associated Golgi protein - - - 0.0000000000000000000000004654 113.0
TLS2_k127_347956_25 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07667 - - 0.000000000000000000131 95.0
TLS2_k127_347956_26 - - - - 0.0000000000000006165 85.0
TLS2_k127_347956_27 General secretion pathway protein K02456 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.0002345 49.0
TLS2_k127_347956_3 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 587.0
TLS2_k127_347956_4 ABC transporter transmembrane region K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 525.0
TLS2_k127_347956_5 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007381 422.0
TLS2_k127_347956_6 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008777 396.0
TLS2_k127_347956_7 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 338.0
TLS2_k127_347956_8 peptidase dimerisation domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000416 340.0
TLS2_k127_347956_9 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 341.0
TLS2_k127_3503834_0 transmembrane transporter activity K18138 - - 0.0 1620.0
TLS2_k127_3503834_1 TonB-dependent receptor - - - 6.617e-209 687.0
TLS2_k127_3503834_10 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000005318 245.0
TLS2_k127_3503834_11 Bacterial regulatory helix-turn-helix protein, lysR family K03576 - - 0.00000000000000000000000000000000000000000000000000000000000009705 232.0
TLS2_k127_3503834_12 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.0000000000000000000000000000000000000000000000000006537 196.0
TLS2_k127_3503834_13 Histidine kinase K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000004271 175.0
TLS2_k127_3503834_14 FMN binding - - - 0.00000000000000000000000000000000000000008357 164.0
TLS2_k127_3503834_15 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000001045 141.0
TLS2_k127_3503834_17 Transcriptional regulator PadR-like family - - - 0.000000000000003539 82.0
TLS2_k127_3503834_18 Glycosyl transferases group 1 - - - 0.00000001795 57.0
TLS2_k127_3503834_19 Transcriptional regulator PadR-like family - - - 0.00000006845 58.0
TLS2_k127_3503834_2 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 637.0
TLS2_k127_3503834_3 efflux transmembrane transporter activity K18300,K18308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 486.0
TLS2_k127_3503834_4 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 510.0
TLS2_k127_3503834_5 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 469.0
TLS2_k127_3503834_6 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 349.0
TLS2_k127_3503834_7 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007507 277.0
TLS2_k127_3503834_8 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000181 291.0
TLS2_k127_3503834_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008335 274.0
TLS2_k127_351297_0 Multicopper oxidase K22348 - 1.16.3.3 2.622e-226 718.0
TLS2_k127_351297_1 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 590.0
TLS2_k127_351297_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008562 477.0
TLS2_k127_351297_3 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006884 280.0
TLS2_k127_351297_4 Tricorn protease C1 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000008264 252.0
TLS2_k127_351297_5 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000009097 194.0
TLS2_k127_351297_6 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000003801 151.0
TLS2_k127_351297_8 Cupin 2, conserved barrel domain protein - - - 0.000001603 56.0
TLS2_k127_3524653_0 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 468.0
TLS2_k127_3524653_1 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000002317 171.0
TLS2_k127_3524653_2 Protein of unknown function (DUF2911) - - - 0.0000000000000000000000000001221 126.0
TLS2_k127_3524653_3 Sigma-70 region 2 K03088 - - 0.000000000000000000000000001186 121.0
TLS2_k127_3524653_4 deaminated base DNA N-glycosylase activity K21929 - 3.2.2.27 0.0002548 53.0
TLS2_k127_3610226_0 glutamate carboxypeptidase K01301 - 3.4.17.21 1.172e-211 689.0
TLS2_k127_3610226_1 efflux transmembrane transporter activity - - - 8.394e-202 658.0
TLS2_k127_3610226_10 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007056 378.0
TLS2_k127_3610226_11 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 329.0
TLS2_k127_3610226_12 Belongs to the phosphatidylserine decarboxylase family K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000004334 231.0
TLS2_k127_3610226_13 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000001722 229.0
TLS2_k127_3610226_14 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.000000000000000000000000000000000000000000000000000000000000006221 225.0
TLS2_k127_3610226_15 Pectinacetylesterase - - - 0.000000000000000000000000000000000000000000000000000000003383 221.0
TLS2_k127_3610226_16 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000387 201.0
TLS2_k127_3610226_17 - - - - 0.0000000000000000000000000000000000000000000000000001262 201.0
TLS2_k127_3610226_18 Protein of unknown function (DUF1572) - - - 0.0000000000000000000000000000000000000000000000006601 183.0
TLS2_k127_3610226_19 PFAM Major Facilitator Superfamily K08223 - - 0.000000000000000000000000000000000000000000001695 181.0
TLS2_k127_3610226_2 Penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 585.0
TLS2_k127_3610226_20 Belongs to the UPF0145 family - - - 0.00000000000000000000000000000000000000008905 157.0
TLS2_k127_3610226_21 OmpA family - - - 0.0000000000000000000000000000000000000001159 161.0
TLS2_k127_3610226_22 - - - - 0.0000000000000000000000000000000000000003605 171.0
TLS2_k127_3610226_23 SWI complex, BAF60b domains - - - 0.00000000000000000000000000000000001159 142.0
TLS2_k127_3610226_24 Penicillinase repressor - - - 0.000000000000000000000000000014 122.0
TLS2_k127_3610226_25 - - - - 0.0000000000000000004265 94.0
TLS2_k127_3610226_26 - - - - 0.00000000000000002828 84.0
TLS2_k127_3610226_27 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000002317 84.0
TLS2_k127_3610226_28 - - - - 0.000000000000005122 87.0
TLS2_k127_3610226_29 Cytochrome c - - - 0.00000000007246 70.0
TLS2_k127_3610226_3 Rhodanese Homology Domain K01069,K03797 - 3.1.2.6,3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 541.0
TLS2_k127_3610226_30 Amidohydrolase family - - - 0.00001538 57.0
TLS2_k127_3610226_31 Domain of unknown function (DUF4412) - - - 0.0003098 51.0
TLS2_k127_3610226_32 Outer membrane protein beta-barrel family - - - 0.0009943 52.0
TLS2_k127_3610226_4 DNA recombination K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 441.0
TLS2_k127_3610226_5 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 414.0
TLS2_k127_3610226_6 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 410.0
TLS2_k127_3610226_7 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004422 413.0
TLS2_k127_3610226_8 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000532 406.0
TLS2_k127_3610226_9 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004332 386.0
TLS2_k127_3635447_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1167.0
TLS2_k127_3635447_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1118.0
TLS2_k127_3635447_10 Inorganic pyrophosphatase K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000876 302.0
TLS2_k127_3635447_11 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 307.0
TLS2_k127_3635447_12 nuclear chromosome segregation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007974 325.0
TLS2_k127_3635447_13 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006085 268.0
TLS2_k127_3635447_14 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000003328 236.0
TLS2_k127_3635447_15 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000004727 245.0
TLS2_k127_3635447_16 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000001577 214.0
TLS2_k127_3635447_17 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000005596 201.0
TLS2_k127_3635447_18 COG0491 Zn-dependent hydrolases, including glyoxylases - GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 - 0.0000000000000000000000000000000000000000000000000001152 196.0
TLS2_k127_3635447_19 Polynucleotide kinase 3 phosphatase K03273 - 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000005738 170.0
TLS2_k127_3635447_2 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 9.884e-308 968.0
TLS2_k127_3635447_20 Iron-sulphur cluster biosynthesis - - - 0.0000000000000000000000000000000000001516 146.0
TLS2_k127_3635447_21 Thioredoxin-like domain K03671 - - 0.000000000000000000000000000000000001648 141.0
TLS2_k127_3635447_22 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000000000000000000000000003719 152.0
TLS2_k127_3635447_23 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000000000000000001004 136.0
TLS2_k127_3635447_24 Bacterial Ig-like domain - - - 0.0000000000000000000000000000005553 138.0
TLS2_k127_3635447_25 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000001753 130.0
TLS2_k127_3635447_26 WHG domain - - - 0.0000000000000000000000002687 114.0
TLS2_k127_3635447_27 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000001881 121.0
TLS2_k127_3635447_28 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division K20543 - - 0.0000000000000000002152 103.0
TLS2_k127_3635447_29 WD40-like Beta Propeller Repeat - - - 0.000000000000000001678 97.0
TLS2_k127_3635447_3 HELICc2 K03722 - 3.6.4.12 2.071e-225 725.0
TLS2_k127_3635447_30 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.000000000000000009866 97.0
TLS2_k127_3635447_31 - - - - 0.0000000001227 70.0
TLS2_k127_3635447_32 Belongs to the universal stress protein A family - - - 0.000000008641 62.0
TLS2_k127_3635447_33 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000004351 57.0
TLS2_k127_3635447_34 FOG TPR repeat - - - 0.0002366 51.0
TLS2_k127_3635447_4 Sulfate permease family K03321 - - 3.499e-201 641.0
TLS2_k127_3635447_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 515.0
TLS2_k127_3635447_6 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004249 506.0
TLS2_k127_3635447_7 Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 469.0
TLS2_k127_3635447_8 pyrroloquinoline quinone binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 417.0
TLS2_k127_3635447_9 type II secretion system protein E K02243,K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 367.0
TLS2_k127_3642371_0 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 489.0
TLS2_k127_3642371_1 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 404.0
TLS2_k127_3642371_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006242 289.0
TLS2_k127_3642371_3 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000005323 257.0
TLS2_k127_3642371_4 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.000000000000000000000000000000000000000000000000000000000000000000002618 247.0
TLS2_k127_3642371_5 DinB family - - - 0.00000000000000000000000000000000000000000001063 169.0
TLS2_k127_3642371_6 - - - - 0.00000000000000000000000000000000000001788 152.0
TLS2_k127_3642371_7 Regulates arginine biosynthesis genes K03402 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006355,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901605,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000006485 126.0
TLS2_k127_3642371_8 - - - - 0.000002808 57.0
TLS2_k127_364269_0 Acyl-CoA dehydrogenase, middle domain - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 5.642e-219 698.0
TLS2_k127_364269_1 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009865 539.0
TLS2_k127_364269_2 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000002775 254.0
TLS2_k127_364269_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - 0.0000000000000000000000000000000000000000000808 162.0
TLS2_k127_364269_4 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.0000000000000000000000000000000009135 143.0
TLS2_k127_364269_5 long-chain fatty acid transporting porin activity - - - 0.0000005311 61.0
TLS2_k127_3686644_0 Baseplate J-like protein - - - 1.912e-219 709.0
TLS2_k127_3686644_1 Late control gene D protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 456.0
TLS2_k127_3686644_2 Baseplate assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000947 272.0
TLS2_k127_3686644_3 - - - - 0.000000000000000000000000000000000006651 139.0
TLS2_k127_3686644_4 PFAM Gene 25-like lysozyme K06903 - - 0.00000000000000000000000000000000002231 144.0
TLS2_k127_3686644_5 LysM domain - - - 0.0000000000000000000000000356 110.0
TLS2_k127_3699965_0 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 525.0
TLS2_k127_3699965_1 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 489.0
TLS2_k127_3699965_10 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000007529 190.0
TLS2_k127_3699965_11 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000002838 190.0
TLS2_k127_3699965_12 DALR_2 K01883 - 6.1.1.16 0.000000000000000000000001531 109.0
TLS2_k127_3699965_13 YtxH-like protein - - - 0.0000000000000000001427 99.0
TLS2_k127_3699965_14 Signal transduction histidine kinase - - - 0.0006705 49.0
TLS2_k127_3699965_2 Phosphoglucose isomerase K01810 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004748 458.0
TLS2_k127_3699965_3 PFAM Amidohydrolase 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 366.0
TLS2_k127_3699965_4 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004064 308.0
TLS2_k127_3699965_5 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 294.0
TLS2_k127_3699965_6 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000005986 237.0
TLS2_k127_3699965_7 Mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000006727 233.0
TLS2_k127_3699965_8 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000002097 199.0
TLS2_k127_3699965_9 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000000006869 191.0
TLS2_k127_3705197_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 6.756e-226 711.0
TLS2_k127_3705197_1 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 532.0
TLS2_k127_3705197_10 Belongs to the short-chain dehydrogenases reductases (SDR) family K05886 - 1.1.1.276 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001436 278.0
TLS2_k127_3705197_11 Belongs to the peptidase S51 family K13282 - 3.4.15.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000009342 267.0
TLS2_k127_3705197_12 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002126 273.0
TLS2_k127_3705197_13 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000006852 201.0
TLS2_k127_3705197_14 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000000000000000000000000001398 197.0
TLS2_k127_3705197_15 Glucose inhibited division protein A K21401 - 1.3.99.38 0.00000000000000000000000000000000000000000003913 178.0
TLS2_k127_3705197_16 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000001167 154.0
TLS2_k127_3705197_17 Methyltransferase domain - - - 0.0000000000000000000000000000000278 136.0
TLS2_k127_3705197_18 Thioredoxin - - - 0.00000000000000000000000000001132 126.0
TLS2_k127_3705197_19 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.0000000000000000000000001529 123.0
TLS2_k127_3705197_2 TrkA-N domain K03316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 502.0
TLS2_k127_3705197_21 toxin-antitoxin pair type II binding K19159 - - 0.0000000000000005615 80.0
TLS2_k127_3705197_22 negative regulation of transcription, DNA-templated - - - 0.0000000000000009286 83.0
TLS2_k127_3705197_3 neurotransmitter:sodium symporter activity K03308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 458.0
TLS2_k127_3705197_4 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000859 432.0
TLS2_k127_3705197_5 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 442.0
TLS2_k127_3705197_6 PFAM histone deacetylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 391.0
TLS2_k127_3705197_7 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008239 384.0
TLS2_k127_3705197_8 Amidohydrolase family K12960,K20810 - 3.5.4.28,3.5.4.31,3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 378.0
TLS2_k127_3705197_9 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00015 - 1.1.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 322.0
TLS2_k127_3749574_0 efflux transmembrane transporter activity - - - 1.001e-299 949.0
TLS2_k127_3749574_1 ABC transporter K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 578.0
TLS2_k127_3749574_2 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000000000000004752 176.0
TLS2_k127_3783565_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1323.0
TLS2_k127_3783565_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 502.0
TLS2_k127_3783565_10 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002903 342.0
TLS2_k127_3783565_11 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 302.0
TLS2_k127_3783565_12 Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine K18911 - 2.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000004961 274.0
TLS2_k127_3783565_13 NIF3 (NGG1p interacting factor 3) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004684 263.0
TLS2_k127_3783565_14 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001321 259.0
TLS2_k127_3783565_15 ABC transporter K05847 - - 0.0000000000000000000000000000000000000000000000000000000000000000004539 237.0
TLS2_k127_3783565_16 COG4257 Streptogramin lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000004766 246.0
TLS2_k127_3783565_17 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000002156 189.0
TLS2_k127_3783565_18 Glutamate-cysteine ligase family 2(GCS2) K01919 - 6.3.2.2 0.00000000000000000000000000000000000000000000000002923 194.0
TLS2_k127_3783565_19 Gamma-glutamyltranspeptidase - - - 0.00000000000000000000000000000000000000000197 162.0
TLS2_k127_3783565_2 DinB superfamily K18912 - 1.14.99.50 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003644 475.0
TLS2_k127_3783565_20 Could be involved in insertion of integral membrane proteins into the membrane K03217,K08998 - - 0.000000000000000000000000000001759 121.0
TLS2_k127_3783565_22 Curli production assembly/transport component CsgG K04087 - - 0.0000000000000000000000000009708 125.0
TLS2_k127_3783565_23 Belongs to the NiCoT transporter (TC 2.A.52) family K07241 - - 0.000000000000000000000000001512 123.0
TLS2_k127_3783565_24 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.000000000000000000000000003599 121.0
TLS2_k127_3783565_25 cellulose binding - - - 0.000000000000000000000000008783 129.0
TLS2_k127_3783565_26 cell adhesion involved in biofilm formation K07004,K12132 - 2.7.11.1 0.000000000000000000005008 110.0
TLS2_k127_3783565_27 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000003662 87.0
TLS2_k127_3783565_28 Acylphosphatase K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000002145 76.0
TLS2_k127_3783565_29 Polymer-forming cytoskeletal - - - 0.000000000002893 75.0
TLS2_k127_3783565_3 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003852 444.0
TLS2_k127_3783565_30 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000001077 60.0
TLS2_k127_3783565_31 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.0000001449 62.0
TLS2_k127_3783565_4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007198 426.0
TLS2_k127_3783565_5 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003085 391.0
TLS2_k127_3783565_6 Cellulose biosynthesis protein BcsQ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 342.0
TLS2_k127_3783565_7 M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) K05845,K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 351.0
TLS2_k127_3783565_8 cAMP biosynthetic process K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 351.0
TLS2_k127_3783565_9 Fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 334.0
TLS2_k127_3798146_0 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 615.0
TLS2_k127_3798146_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 542.0
TLS2_k127_3798146_10 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005438 273.0
TLS2_k127_3798146_11 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000003152 277.0
TLS2_k127_3798146_12 HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000001515 243.0
TLS2_k127_3798146_13 Belongs to the TrpC family K01609 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000001403 227.0
TLS2_k127_3798146_14 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000003888 226.0
TLS2_k127_3798146_15 RNA-binding protein homologous to eukaryotic snRNP - - - 0.000000000000000000000000000000000000007929 164.0
TLS2_k127_3798146_16 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.0000000000000000000000000000000000003552 143.0
TLS2_k127_3798146_17 HD superfamily hydrolase involved in NAD metabolism K00950 - 2.7.6.3 0.000000000000000000000000000000002875 138.0
TLS2_k127_3798146_18 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000005043 143.0
TLS2_k127_3798146_19 phosphoenolpyruvate-dependent sugar phosphotransferase system K02768,K02769,K02770,K02806 - 2.7.1.202 0.000000000000000000000000000000006109 133.0
TLS2_k127_3798146_2 7TM receptor with intracellular HD hydrolase K07037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 483.0
TLS2_k127_3798146_20 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000004223 120.0
TLS2_k127_3798146_21 PFAM NAD dependent epimerase dehydratase family K18981 - 1.1.1.203 0.000000000000006469 79.0
TLS2_k127_3798146_22 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000174 84.0
TLS2_k127_3798146_23 cell envelope-related transcriptional attenuator - - - 0.0000001172 59.0
TLS2_k127_3798146_24 - - - - 0.00007976 50.0
TLS2_k127_3798146_3 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 409.0
TLS2_k127_3798146_4 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005333 389.0
TLS2_k127_3798146_5 PhoH-like protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000097 380.0
TLS2_k127_3798146_6 ABC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 372.0
TLS2_k127_3798146_7 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 344.0
TLS2_k127_3798146_8 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001182 280.0
TLS2_k127_3798146_9 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000183 286.0
TLS2_k127_3866726_0 cellulase activity - - - 1.724e-224 713.0
TLS2_k127_3866726_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 581.0
TLS2_k127_3866726_10 transport - - - 0.000000008086 68.0
TLS2_k127_3866726_2 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 597.0
TLS2_k127_3866726_3 asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 449.0
TLS2_k127_3866726_4 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 312.0
TLS2_k127_3866726_5 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005074 275.0
TLS2_k127_3866726_6 Di-haem oxidoreductase, putative peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000003984 228.0
TLS2_k127_3866726_7 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000003521 208.0
TLS2_k127_3866726_9 - - - - 0.000000000000000000000000000000000001945 149.0
TLS2_k127_3889572_0 Sodium:solute symporter family K14393 - - 1.259e-213 677.0
TLS2_k127_3889572_1 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 544.0
TLS2_k127_3889572_10 Carboxypeptidase regulatory-like domain - - - 0.00000000000000002518 95.0
TLS2_k127_3889572_11 solute sodium symporter, small subunit - - - 0.000000000000003122 78.0
TLS2_k127_3889572_12 peptidyl-prolyl isomerase K03770 - 5.2.1.8 0.000000005065 68.0
TLS2_k127_3889572_13 membrane - - - 0.00000007644 64.0
TLS2_k127_3889572_2 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 474.0
TLS2_k127_3889572_3 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003595 259.0
TLS2_k127_3889572_4 Di-haem oxidoreductase, putative peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000183 235.0
TLS2_k127_3889572_5 epimerase K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000007683 218.0
TLS2_k127_3889572_6 - - - - 0.0000000000000000000000000000000000000000000000000000000001012 211.0
TLS2_k127_3889572_7 SpoU rRNA Methylase family K03437 - - 0.00000000000000000000000000000003844 132.0
TLS2_k127_3889572_8 - - - - 0.00000000000000000000000008798 109.0
TLS2_k127_3889572_9 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000256 101.0
TLS2_k127_3909330_0 heavy metal translocating P-type ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 5.465e-219 707.0
TLS2_k127_3909330_1 Fumarase C C-terminus K01744 - 4.3.1.1 1.064e-214 684.0
TLS2_k127_3909330_10 - - - - 0.00001078 57.0
TLS2_k127_3909330_2 POT family K03305 - - 4.34e-202 641.0
TLS2_k127_3909330_3 protein histidine kinase activity K03407,K07678 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 325.0
TLS2_k127_3909330_4 Acetyltransferase (GNAT) domain K22479 - - 0.00000000000000000000000000000000000000000000000000000000002433 211.0
TLS2_k127_3909330_5 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.000000000000000000000000009148 111.0
TLS2_k127_3909330_7 Gram-negative bacterial TonB protein C-terminal - - - 0.0000000000000000008138 97.0
TLS2_k127_3909330_9 Heavy metal transport detoxification protein - - - 0.000000000000008716 76.0
TLS2_k127_3922573_0 ImcF-related N-terminal domain K11891 - - 7.145e-238 782.0
TLS2_k127_3922573_1 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005634 560.0
TLS2_k127_3922573_10 PFAM PKD domain containing protein - - - 0.0000000000001535 84.0
TLS2_k127_3922573_11 - - - - 0.0000000000004161 74.0
TLS2_k127_3922573_12 protein involved in formation of curli polymers - - - 0.0000000003122 70.0
TLS2_k127_3922573_13 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000003672 62.0
TLS2_k127_3922573_14 FHA domain protein - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.0000000007029 71.0
TLS2_k127_3922573_15 - - - - 0.00000001571 64.0
TLS2_k127_3922573_16 - - - - 0.0000003723 62.0
TLS2_k127_3922573_17 Pkd domain containing protein K12567 - 2.7.11.1 0.00003111 57.0
TLS2_k127_3922573_2 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE K11893 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006447 460.0
TLS2_k127_3922573_3 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000007159 281.0
TLS2_k127_3922573_4 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000001054 256.0
TLS2_k127_3922573_5 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000001239 237.0
TLS2_k127_3922573_6 Type VI secretion system protein DotU K11892 - - 0.00000000000000000000000000000000000000000000000001593 190.0
TLS2_k127_3922573_7 curli production assembly transport component CsgG K04087 - - 0.000000000000000000000000000000000000001436 166.0
TLS2_k127_3922573_8 Nacht domain - - - 0.000000000000000000000000000003697 131.0
TLS2_k127_3922573_9 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000001646 121.0
TLS2_k127_395100_0 Glycogen debranching enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 633.0
TLS2_k127_395100_1 Carbohydrate ABC transporter ATP-binding protein, CUT1 family K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 376.0
TLS2_k127_395100_2 Amylo-alpha-1,6-glucosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 390.0
TLS2_k127_395100_3 alpha,alpha-trehalase activity K01194,K03931 GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716 3.2.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 322.0
TLS2_k127_395100_4 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000008341 271.0
TLS2_k127_395100_5 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002359 263.0
TLS2_k127_395100_6 transmembrane transport K02025,K10201,K15771 - - 0.0000000000000002649 92.0
TLS2_k127_3980390_0 TIGRFAM TRAP transporter, 4TM 12TM fusion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009963 495.0
TLS2_k127_3980390_1 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 484.0
TLS2_k127_3980390_2 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006112 484.0
TLS2_k127_3980390_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 310.0
TLS2_k127_3980390_4 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000000000000002135 214.0
TLS2_k127_3980390_5 Peptidase M50B-like - - - 0.000000000000000000000000000000000000001174 160.0
TLS2_k127_3980390_6 transport system, periplasmic component K07080 - - 0.000000000000000000000000000000000000003975 166.0
TLS2_k127_3980390_7 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000001369 142.0
TLS2_k127_3980390_8 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000001231 134.0
TLS2_k127_403783_0 metallocarboxypeptidase activity K14054 - - 1.002e-288 914.0
TLS2_k127_403783_1 Tricorn protease homolog K08676 - - 2.014e-266 840.0
TLS2_k127_403783_2 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009757 363.0
TLS2_k127_403783_3 Transcriptional regulator PadR-like family - - - 0.00000000000000001974 86.0
TLS2_k127_403783_4 WD40 repeats - - - 0.00000416 59.0
TLS2_k127_4072735_0 TonB dependent receptor - - - 3.756e-309 978.0
TLS2_k127_4072735_1 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 512.0
TLS2_k127_4072735_2 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007467 488.0
TLS2_k127_4072735_3 SusD family K21572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 322.0
TLS2_k127_4072735_4 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000001614 234.0
TLS2_k127_4072735_5 Copper type II ascorbate-dependent monooxygenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000003175 231.0
TLS2_k127_4072735_6 cAMP biosynthetic process K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000004831 210.0
TLS2_k127_4117015_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 2.34e-204 643.0
TLS2_k127_4117015_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 7.114e-198 635.0
TLS2_k127_4117015_10 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000001341 216.0
TLS2_k127_4117015_11 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000003533 183.0
TLS2_k127_4117015_12 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000000002036 146.0
TLS2_k127_4117015_2 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 488.0
TLS2_k127_4117015_3 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 437.0
TLS2_k127_4117015_4 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 390.0
TLS2_k127_4117015_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 336.0
TLS2_k127_4117015_6 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009613 306.0
TLS2_k127_4117015_7 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 306.0
TLS2_k127_4117015_8 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002168 284.0
TLS2_k127_4117015_9 Bacillithiol biosynthesis BshC K22136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001948 260.0
TLS2_k127_4119012_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 578.0
TLS2_k127_4119012_1 glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 508.0
TLS2_k127_4119012_2 GGDEF domain K01768,K02488,K07676,K10715,K20976 GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009927,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3,2.7.7.65,4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 416.0
TLS2_k127_4119012_3 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000873 348.0
TLS2_k127_4119012_4 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 305.0
TLS2_k127_4119012_5 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004075 280.0
TLS2_k127_4119012_6 HEAT repeats - - - 0.00000000000000000000000000000000000000000000002209 186.0
TLS2_k127_4119012_7 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000006347 155.0
TLS2_k127_4122152_0 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 492.0
TLS2_k127_4122152_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000823 488.0
TLS2_k127_4122152_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 291.0
TLS2_k127_4122152_11 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002531 296.0
TLS2_k127_4122152_12 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000787 232.0
TLS2_k127_4122152_13 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000002994 221.0
TLS2_k127_4122152_14 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000006245 205.0
TLS2_k127_4122152_15 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000005013 185.0
TLS2_k127_4122152_16 - - - - 0.00000000000000000000000000000000000000001968 161.0
TLS2_k127_4122152_17 - - - - 0.00000000000000000000000000000000000000007322 168.0
TLS2_k127_4122152_18 ECF sigma factor - - - 0.000000000000000000000000000000000000001235 154.0
TLS2_k127_4122152_19 PFAM helix-turn-helix domain protein - - - 0.000000000000000000000000000000000000004884 149.0
TLS2_k127_4122152_2 Zinc-dependent metalloprotease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 462.0
TLS2_k127_4122152_20 Pfam matches to PF08238.7 Sel1, and to PF08238.7 Sel1, and to PF08238.7 Sel1, and to PF08238.7 Sel1 K07126 - - 0.000000000000000000000000000000000006827 152.0
TLS2_k127_4122152_21 - K01992 - - 0.0000000000000000000000000000000001254 146.0
TLS2_k127_4122152_22 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000005902 124.0
TLS2_k127_4122152_23 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000000000002522 115.0
TLS2_k127_4122152_24 phosphohistidine phosphatase, SixA - - - 0.0000000000000000000000002653 121.0
TLS2_k127_4122152_25 PIN domain - - - 0.000000000000000000000000457 112.0
TLS2_k127_4122152_26 NAD dependent epimerase/dehydratase family K05281 - 1.3.1.45 0.0000000000000000000005019 104.0
TLS2_k127_4122152_27 negative regulation of transcription, DNA-templated - - - 0.000000000000000000004329 98.0
TLS2_k127_4122152_28 ABC-2 family transporter protein K01992 - - 0.00000000000000001494 93.0
TLS2_k127_4122152_29 SnoaL-like domain - - - 0.0000000000005421 76.0
TLS2_k127_4122152_3 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 466.0
TLS2_k127_4122152_30 Transcriptional regulator PadR-like family - - - 0.00000000009342 69.0
TLS2_k127_4122152_31 - - - - 0.0000000002409 63.0
TLS2_k127_4122152_32 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0000000987 60.0
TLS2_k127_4122152_33 PIN domain K07064 - - 0.0000007445 57.0
TLS2_k127_4122152_34 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00007518 53.0
TLS2_k127_4122152_4 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 450.0
TLS2_k127_4122152_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 403.0
TLS2_k127_4122152_6 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 366.0
TLS2_k127_4122152_7 abc transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005455 327.0
TLS2_k127_4122152_8 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 323.0
TLS2_k127_4122152_9 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006982 307.0
TLS2_k127_4124938_0 Heat shock 70 kDa protein K04043 - - 9.933e-263 827.0
TLS2_k127_4124938_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 5.969e-246 765.0
TLS2_k127_4124938_10 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006644 264.0
TLS2_k127_4124938_11 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007362 271.0
TLS2_k127_4124938_12 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005603 277.0
TLS2_k127_4124938_13 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000006628 264.0
TLS2_k127_4124938_14 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000001935 259.0
TLS2_k127_4124938_15 Phosphomethylpyrimidine kinase K00868,K00941,K03147,K21219 GO:0008150,GO:0040007 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7,4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000007625 242.0
TLS2_k127_4124938_16 FAD dependent oxidoreductase K03153 - 1.4.3.19 0.000000000000000000000000000000000000000000000000000000000000000002421 241.0
TLS2_k127_4124938_17 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - 0.000000000000000000000000000000000000000000000000000000000000004623 227.0
TLS2_k127_4124938_18 CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000008814 214.0
TLS2_k127_4124938_19 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000682 205.0
TLS2_k127_4124938_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 2.919e-213 674.0
TLS2_k127_4124938_20 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000009821 183.0
TLS2_k127_4124938_21 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000001403 182.0
TLS2_k127_4124938_22 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.0000000000000000000000000000000000000001089 160.0
TLS2_k127_4124938_23 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000004424 154.0
TLS2_k127_4124938_24 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000203 139.0
TLS2_k127_4124938_25 Galactose oxidase, central domain - - - 0.000000000000000000000000000000001817 142.0
TLS2_k127_4124938_26 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000005158 115.0
TLS2_k127_4124938_27 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000000000001774 90.0
TLS2_k127_4124938_28 - - - - 0.000000000000000004166 97.0
TLS2_k127_4124938_29 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000417 95.0
TLS2_k127_4124938_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 559.0
TLS2_k127_4124938_31 Intracellular proteinase inhibitor - - - 0.000000548 58.0
TLS2_k127_4124938_32 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00003199 56.0
TLS2_k127_4124938_33 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.0002712 52.0
TLS2_k127_4124938_4 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009658 444.0
TLS2_k127_4124938_5 PFAM CBS domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000897 432.0
TLS2_k127_4124938_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 351.0
TLS2_k127_4124938_7 Trypsin K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004577 306.0
TLS2_k127_4124938_8 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000007243 273.0
TLS2_k127_4124938_9 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002072 271.0
TLS2_k127_4165271_0 metallocarboxypeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 643.0
TLS2_k127_4165271_1 cystathionine K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 509.0
TLS2_k127_4165271_2 amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003949 346.0
TLS2_k127_4165271_3 PFAM Amino acid permease K03294,K13868 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 333.0
TLS2_k127_4165271_4 Belongs to the AB hydrolase superfamily. MetX family K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000002765 243.0
TLS2_k127_4165271_5 SpoU rRNA Methylase family K03437 - - 0.0000000001027 63.0
TLS2_k127_416602_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 521.0
TLS2_k127_416602_1 DHH family K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005633 497.0
TLS2_k127_416602_10 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000003285 184.0
TLS2_k127_416602_11 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.182 0.00000000000000000000000000000000000000000000002103 188.0
TLS2_k127_416602_12 STAS domain K04749 - - 0.0000000000000000000000000000000000000000000002632 170.0
TLS2_k127_416602_13 Met-10+ like-protein K02687 - - 0.000000000000000000000000000000000000000002972 165.0
TLS2_k127_416602_14 PFAM Histidine triad (HIT) protein K02503 - - 0.0000000000000000000000000000000000000001429 152.0
TLS2_k127_416602_15 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000000000000000000000000000492 162.0
TLS2_k127_416602_16 PFAM BioY protein K03523 - - 0.0000000000000000000000000003699 122.0
TLS2_k127_416602_17 Yqey-like protein K09117 - - 0.00000000000000000000000009743 111.0
TLS2_k127_416602_18 COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase) K04757 - 2.7.11.1 0.0000000000000000001371 99.0
TLS2_k127_416602_19 CAAX protease self-immunity K07052 - - 0.00000000000002102 81.0
TLS2_k127_416602_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 456.0
TLS2_k127_416602_20 Zn-ribbon protein, possibly nucleic acid-binding K07164 - - 0.000000000002604 76.0
TLS2_k127_416602_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 377.0
TLS2_k127_416602_4 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 387.0
TLS2_k127_416602_5 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 353.0
TLS2_k127_416602_6 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 324.0
TLS2_k127_416602_7 Arginine deiminase K01478 - 3.5.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001032 284.0
TLS2_k127_416602_8 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.00000000000000000000000000000000000000000000000000000000000000000001289 240.0
TLS2_k127_416602_9 EXOIII K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000007049 189.0
TLS2_k127_4172678_0 Tetratricopeptide repeat K12132 - 2.7.11.1 2.091e-198 648.0
TLS2_k127_4172678_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007463 562.0
TLS2_k127_4172678_11 Belongs to the TPP enzyme family - - - 0.0000000000000000000000000001686 133.0
TLS2_k127_4172678_12 RNA polymerase sigma factor containing a TPR repeat domain K03088 - - 0.000000000000000000001664 94.0
TLS2_k127_4172678_13 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000002046 108.0
TLS2_k127_4172678_14 HAF family - - - 0.000000000000000000003207 109.0
TLS2_k127_4172678_17 amine dehydrogenase activity - - - 0.0004474 52.0
TLS2_k127_4172678_2 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 399.0
TLS2_k127_4172678_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007322 347.0
TLS2_k127_4172678_4 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000005198 277.0
TLS2_k127_4172678_5 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000004757 179.0
TLS2_k127_4172678_6 DNA-templated transcription, initiation K02405 - - 0.00000000000000000000000000000000000000000000000521 185.0
TLS2_k127_4172678_7 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000001224 176.0
TLS2_k127_4172678_8 DNA-templated transcription, initiation K02405 - - 0.000000000000000000000000000000000000000000001719 173.0
TLS2_k127_4172678_9 Tellurite resistance protein TehB - - - 0.00000000000000000000000000000000000000005524 160.0
TLS2_k127_4207416_0 (ABC) transporter K06147,K06148 - - 2.115e-211 674.0
TLS2_k127_4207416_1 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 512.0
TLS2_k127_4207416_10 - - - - 0.000004765 56.0
TLS2_k127_4207416_11 Protein kinase domain - - - 0.0002846 53.0
TLS2_k127_4207416_2 Domain of unknown function (DUF4143) K07133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007686 469.0
TLS2_k127_4207416_3 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004816 444.0
TLS2_k127_4207416_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 428.0
TLS2_k127_4207416_5 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 357.0
TLS2_k127_4207416_6 Tetratricopeptide repeat K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000009153 252.0
TLS2_k127_4207416_7 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000008438 201.0
TLS2_k127_4207416_8 DNA-templated transcription, initiation K02405 - - 0.000000000000000000000000000000000000002431 157.0
TLS2_k127_4207416_9 MacB-like periplasmic core domain K02004 - - 0.000000005478 61.0
TLS2_k127_4240080_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.015e-289 898.0
TLS2_k127_4240080_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 5.834e-235 767.0
TLS2_k127_4240080_10 - - - - 0.0000001446 62.0
TLS2_k127_4240080_2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K00344,K00966,K01840,K03431,K15778,K16881 - 1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8 6.612e-229 740.0
TLS2_k127_4240080_3 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 405.0
TLS2_k127_4240080_4 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 330.0
TLS2_k127_4240080_5 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 300.0
TLS2_k127_4240080_6 peptidase S45, penicillin amidase K01434 - 3.5.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000008304 274.0
TLS2_k127_4240080_7 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000398 256.0
TLS2_k127_4240080_8 Aerotolerance regulator N-terminal - - - 0.0000000000000000000000000000000000000000000000000000236 211.0
TLS2_k127_4240080_9 - - - - 0.0000000000000000000000000000000002778 138.0
TLS2_k127_4275946_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 477.0
TLS2_k127_4275946_1 Glycosyl transferase family 21 K00694 - 2.4.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 399.0
TLS2_k127_4275946_2 Protein of unknown function (DUF3131) - - - 0.000000000000000000000000000000000000000000000000000000000004757 224.0
TLS2_k127_4275946_3 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000002282 207.0
TLS2_k127_4275946_4 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000115 147.0
TLS2_k127_4275946_5 Glycosyl hydrolase family 26 - - - 0.000000000000000000000000000000000004284 152.0
TLS2_k127_4293521_0 Domain of unknown function (DUF5118) - - - 1.634e-318 988.0
TLS2_k127_4293521_1 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 601.0
TLS2_k127_4293521_2 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003984 481.0
TLS2_k127_4293521_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000007049 235.0
TLS2_k127_4293521_4 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000005881 194.0
TLS2_k127_4293521_5 methyltransferase activity K00563,K02169 - 2.1.1.187,2.1.1.197 0.0000000000000000000000000001757 125.0
TLS2_k127_4293521_6 Transcriptional regulator PadR-like family - - - 0.000000000000000000005741 98.0
TLS2_k127_4335107_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009895 306.0
TLS2_k127_4335107_1 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005685 272.0
TLS2_k127_4335107_2 membrane - - - 0.00000000000000000000000000002914 127.0
TLS2_k127_4335107_3 efflux transmembrane transporter activity - - - 0.000000000000000000000001899 113.0
TLS2_k127_4335107_4 - - - - 0.000000000001243 81.0
TLS2_k127_4342002_0 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 2.079e-219 700.0
TLS2_k127_4342002_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 353.0
TLS2_k127_4342002_2 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 355.0
TLS2_k127_4342002_3 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000000000001518 227.0
TLS2_k127_4342002_4 Penicillin amidase K01434 - 3.5.1.11 0.00000000000000000000000000000000000000000000000002427 195.0
TLS2_k127_4342002_5 PFAM nitrogen-fixing NifU domain protein - - - 0.00000000000000000003317 92.0
TLS2_k127_4425627_0 Alpha-amylase domain K01182 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.10 3.388e-250 783.0
TLS2_k127_4425627_1 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 505.0
TLS2_k127_4425627_10 protein phosphatase 2C domain protein - - - 0.0006789 51.0
TLS2_k127_4425627_2 SMART alpha amylase, catalytic sub domain K01187 - 3.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 464.0
TLS2_k127_4425627_3 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 456.0
TLS2_k127_4425627_4 - - - - 0.0000000000000000000000000000000000000000000000000001579 195.0
TLS2_k127_4425627_5 - - - - 0.000000000000000000000000000000000000000000000000004368 198.0
TLS2_k127_4425627_6 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters - - - 0.000000000000000003337 89.0
TLS2_k127_4425627_8 diguanylate cyclase activity K02000,K04767,K05847,K07168,K09137 - 3.6.3.32 0.0000000000000009716 85.0
TLS2_k127_4425627_9 - - - - 0.0000000000004776 71.0
TLS2_k127_4430481_0 Peptidase dimerisation domain K12941 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 576.0
TLS2_k127_4430481_1 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 409.0
TLS2_k127_4430481_2 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002969 267.0
TLS2_k127_4430481_3 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000008685 106.0
TLS2_k127_4430481_4 - - - - 0.0000000000000000001171 100.0
TLS2_k127_4462426_0 Dipeptidyl peptidase IV (DPP IV) N-terminal region - - - 4.775e-250 796.0
TLS2_k127_4462426_1 Beta-eliminating lyase K00639,K00652 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 519.0
TLS2_k127_4462426_10 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000003033 218.0
TLS2_k127_4462426_11 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000006279 203.0
TLS2_k127_4462426_12 phosphatidate phosphatase activity K00901,K01096,K19302 - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 0.0000000000000000000000000000000000000000137 166.0
TLS2_k127_4462426_13 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000005646 146.0
TLS2_k127_4462426_14 Transglycosylase SLT domain - - - 0.0000000000000000000000000000004299 134.0
TLS2_k127_4462426_15 metal-sulfur cluster biosynthetic - - - 0.00000000000000000000009755 104.0
TLS2_k127_4462426_16 PFAM transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.0000000000000000000003612 110.0
TLS2_k127_4462426_17 Sterol carrier protein domain - - - 0.0000000000000001011 89.0
TLS2_k127_4462426_18 CAAX protease self-immunity - - - 0.0000000000000002455 91.0
TLS2_k127_4462426_2 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 474.0
TLS2_k127_4462426_3 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 436.0
TLS2_k127_4462426_4 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 349.0
TLS2_k127_4462426_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 342.0
TLS2_k127_4462426_6 Domain of unknown function (DUF4153) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 312.0
TLS2_k127_4462426_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000935 301.0
TLS2_k127_4462426_8 LD-carboxypeptidase K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000000000000000000008904 254.0
TLS2_k127_4462426_9 NmrA-like family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000009986 228.0
TLS2_k127_4481707_0 efflux transmembrane transporter activity - - - 1.67e-249 795.0
TLS2_k127_4481707_1 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 2.034e-206 657.0
TLS2_k127_4481707_10 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 349.0
TLS2_k127_4481707_11 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008719 294.0
TLS2_k127_4481707_12 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000001998 233.0
TLS2_k127_4481707_13 Esterase of the alpha-beta hydrolase superfamily - - - 0.0000000000000000000000000000000000000000000006394 183.0
TLS2_k127_4481707_14 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000001266 159.0
TLS2_k127_4481707_15 Peptidase family M48 - - - 0.000000000000000000000000000000000000000002496 167.0
TLS2_k127_4481707_16 Activator of hsp90 atpase 1 family protein - - - 0.000000000000000000000000000000000000004172 159.0
TLS2_k127_4481707_17 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000002382 156.0
TLS2_k127_4481707_18 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000003531 134.0
TLS2_k127_4481707_19 cyclic nucleotide binding K10914 - - 0.00000000000000000000000006874 116.0
TLS2_k127_4481707_2 Aldo/keto reductase family K04782 - 4.2.99.21 1.264e-202 641.0
TLS2_k127_4481707_20 electron transfer activity - - - 0.00000000000000000000000007054 107.0
TLS2_k127_4481707_21 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000002467 106.0
TLS2_k127_4481707_22 negative regulation of transcription, DNA-templated K10947 - - 0.00000000000000000001059 95.0
TLS2_k127_4481707_23 domain protein - - - 0.0000000000000003978 94.0
TLS2_k127_4481707_24 Amidohydrolase family - - - 0.00000000000001425 89.0
TLS2_k127_4481707_25 - - - - 0.00000000000003254 88.0
TLS2_k127_4481707_26 Esterase of the alpha-beta hydrolase superfamily - - - 0.000000492 59.0
TLS2_k127_4481707_3 Beta-lactamase - - - 7.485e-197 637.0
TLS2_k127_4481707_4 Amino acid permease - - - 3.142e-196 628.0
TLS2_k127_4481707_5 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 508.0
TLS2_k127_4481707_6 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 512.0
TLS2_k127_4481707_7 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 499.0
TLS2_k127_4481707_8 DUF1704 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 474.0
TLS2_k127_4481707_9 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 451.0
TLS2_k127_4499965_0 domain, Protein - - - 1.924e-306 951.0
TLS2_k127_4499965_1 PFAM NADH flavin oxidoreductase NADH oxidase K09461 - 1.14.13.40 1.168e-305 960.0
TLS2_k127_4499965_2 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 529.0
TLS2_k127_4499965_3 Alpha/beta hydrolase family K01563,K22318 - 3.8.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 307.0
TLS2_k127_4499965_4 Belongs to the short-chain dehydrogenases reductases (SDR) family K00019,K07535 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000004009 251.0
TLS2_k127_4499965_5 transcriptional regulator - - - 0.00000000000000000000000000000000005111 142.0
TLS2_k127_4499965_6 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0000000000007038 72.0
TLS2_k127_4622066_0 response to abiotic stimulus - - - 3.944e-207 674.0
TLS2_k127_4622066_1 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 325.0
TLS2_k127_4622066_2 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000004667 188.0
TLS2_k127_4622066_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000583 116.0
TLS2_k127_4646194_0 MacB-like periplasmic core domain - - - 1.614e-201 662.0
TLS2_k127_4646194_1 Peptidase dimerisation domain - - - 2.769e-194 619.0
TLS2_k127_4646194_10 amine dehydrogenase activity - - - 0.00009032 55.0
TLS2_k127_4646194_2 C4-dicarboxylate anaerobic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 499.0
TLS2_k127_4646194_3 Aminotransferase class-V K04127 - 5.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 354.0
TLS2_k127_4646194_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000003909 235.0
TLS2_k127_4646194_5 - - - - 0.00000000000000000000000000000000000000000000000000005903 192.0
TLS2_k127_4646194_6 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000004143 162.0
TLS2_k127_4646194_7 WD40 domain protein beta Propeller K03641 - - 0.00000000000000000000000007091 116.0
TLS2_k127_4646194_8 transcriptional regulator PadR family - - - 0.00000000000006656 78.0
TLS2_k127_4646194_9 Outer membrane protein beta-barrel domain - - - 0.00000734 56.0
TLS2_k127_4681158_0 Tricorn protease PDZ domain K08676 - - 0.0 1483.0
TLS2_k127_4681158_1 Amidohydrolase family - - - 0.0 1200.0
TLS2_k127_4681158_10 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 336.0
TLS2_k127_4681158_11 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 329.0
TLS2_k127_4681158_12 TipAS antibiotic-recognition domain K21744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006981 265.0
TLS2_k127_4681158_13 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000003895 189.0
TLS2_k127_4681158_14 translation initiation inhibitor, yjgF family - - - 0.00000000000000000000000000000000000000000001051 173.0
TLS2_k127_4681158_15 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000001949 167.0
TLS2_k127_4681158_16 COGs COG1853 Conserved protein domain typically associated with flavoprotein oxygenase DIM6 NTAB family K00484 - 1.5.1.36 0.0000000000000000000000000000001276 130.0
TLS2_k127_4681158_17 FG-GAP repeat - - - 0.0000000000000000000000000002295 128.0
TLS2_k127_4681158_18 DNA polymerase involved in DNA repair K14161 - - 0.00000001393 67.0
TLS2_k127_4681158_19 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553,K14160 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - 0.00003095 56.0
TLS2_k127_4681158_2 Dienelactone hydrolase family - - - 0.0 1045.0
TLS2_k127_4681158_3 repeat protein - - - 1.993e-226 728.0
TLS2_k127_4681158_4 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 550.0
TLS2_k127_4681158_5 Peptidase family M20/M25/M40 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 469.0
TLS2_k127_4681158_6 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 438.0
TLS2_k127_4681158_7 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007772 426.0
TLS2_k127_4681158_8 Ketopantoate reductase PanE/ApbA C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 394.0
TLS2_k127_4681158_9 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 348.0
TLS2_k127_4716474_0 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004201 529.0
TLS2_k127_4716474_1 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000213 185.0
TLS2_k127_4716474_2 cellular response to DNA damage stimulus - GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - 0.0000000000000000000000000000000000004548 148.0
TLS2_k127_4716474_3 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000008431 102.0
TLS2_k127_4716474_4 CRS1_YhbY K07574 - - 0.0000000000000000002219 91.0
TLS2_k127_4716474_5 Domain of unknown function (DUF2382) - - - 0.0000000000000004805 82.0
TLS2_k127_4716474_6 hyperosmotic response - - - 0.0000000006465 69.0
TLS2_k127_4749445_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 382.0
TLS2_k127_4749445_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 404.0
TLS2_k127_4749445_2 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004985 348.0
TLS2_k127_4749445_3 PFAM DSBA oxidoreductase - - - 0.0000000000000000000000000000004016 131.0
TLS2_k127_4805646_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.0 1368.0
TLS2_k127_4805646_1 Tricorn protease homolog K08676 - - 0.0 1293.0
TLS2_k127_4805646_10 belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000001798 255.0
TLS2_k127_4805646_11 COG1252 NADH dehydrogenase FAD-containing subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001838 257.0
TLS2_k127_4805646_12 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.000000000000000000000000000000000000000001456 167.0
TLS2_k127_4805646_13 CS domain K13993 - - 0.000000000000000000000000009735 117.0
TLS2_k127_4805646_2 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 8.007e-307 958.0
TLS2_k127_4805646_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.193e-298 929.0
TLS2_k127_4805646_4 hydrolase activity, hydrolyzing O-glycosyl compounds K16147 - 2.4.99.16 1.928e-241 764.0
TLS2_k127_4805646_5 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 1.372e-201 638.0
TLS2_k127_4805646_6 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700,K01236 - 2.4.1.18,3.2.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 617.0
TLS2_k127_4805646_7 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009579 522.0
TLS2_k127_4805646_8 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 378.0
TLS2_k127_4805646_9 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000001393 268.0
TLS2_k127_4806978_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007433 485.0
TLS2_k127_4806978_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003434 391.0
TLS2_k127_4806978_2 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006594 375.0
TLS2_k127_4806978_3 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 308.0
TLS2_k127_4806978_4 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000553 274.0
TLS2_k127_4806978_5 membrane - - - 0.00000000000000000000000000000000000000000000000000000000002133 225.0
TLS2_k127_4806978_6 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000005411 186.0
TLS2_k127_4806978_7 Cell division protein FtsQ K03589 - - 0.000000000001441 77.0
TLS2_k127_4806978_8 Putative glutamine amidotransferase - - - 0.00000003014 65.0
TLS2_k127_4889270_0 FtsX-like permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 508.0
TLS2_k127_4889270_1 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007851 332.0
TLS2_k127_4889270_2 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002395 261.0
TLS2_k127_4889270_3 - - - - 0.00000000000000000000000000000000000000000000000000000000001322 216.0
TLS2_k127_4889270_4 TIGRFAM methyltransferase FkbM family - - - 0.00000000000000000000000000000000000000003698 163.0
TLS2_k127_4889270_5 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000008363 136.0
TLS2_k127_4889270_6 Glycosyl transferases group 1 - - - 0.000000000000000000249 95.0
TLS2_k127_4889270_7 Transcriptional regulator PadR-like family - - - 0.0000000000000000156 87.0
TLS2_k127_4889270_8 PD-(D/E)XK nuclease superfamily - - - 0.00001403 53.0
TLS2_k127_4896703_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 0.0 1103.0
TLS2_k127_4896703_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 2.569e-298 936.0
TLS2_k127_4896703_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 481.0
TLS2_k127_4896703_3 fructose 1,6-bisphosphate 1-phosphatase activity K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 432.0
TLS2_k127_4896703_4 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 360.0
TLS2_k127_4896703_5 Competence protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 344.0
TLS2_k127_4896703_6 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 299.0
TLS2_k127_4896703_7 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000007525 91.0
TLS2_k127_4941051_0 PFAM Tripartite tricarboxylate transporter TctA family K07793 - - 5.177e-214 677.0
TLS2_k127_4941051_1 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 525.0
TLS2_k127_4941051_10 amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 391.0
TLS2_k127_4941051_11 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005507 409.0
TLS2_k127_4941051_12 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 383.0
TLS2_k127_4941051_13 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003353 375.0
TLS2_k127_4941051_14 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 342.0
TLS2_k127_4941051_15 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 316.0
TLS2_k127_4941051_16 Predicted membrane protein (DUF2231) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000568 297.0
TLS2_k127_4941051_17 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001289 269.0
TLS2_k127_4941051_18 - - - - 0.00000000000000000000000000000000000000000000000000000000000007435 224.0
TLS2_k127_4941051_19 Aminotransferase class v - - - 0.000000000000000000000000000000000000000000000000000000007918 216.0
TLS2_k127_4941051_2 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 486.0
TLS2_k127_4941051_20 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000285 177.0
TLS2_k127_4941051_21 - - - - 0.0000000000000000000000000000000000000000000000852 175.0
TLS2_k127_4941051_22 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000000000000001259 162.0
TLS2_k127_4941051_23 Histidine kinase - - - 0.00000000000000000000000000000000000000004924 174.0
TLS2_k127_4941051_24 Predicted membrane protein (DUF2243) - - - 0.00000000000000000000000000000000000008057 147.0
TLS2_k127_4941051_25 PFAM phosphoesterase, PA-phosphatase related K19302 - 3.6.1.27 0.00000000000000000000000000000000001417 147.0
TLS2_k127_4941051_26 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000001461 142.0
TLS2_k127_4941051_27 Penicillinase repressor - - - 0.00000000000000000000000000002276 123.0
TLS2_k127_4941051_28 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000002162 111.0
TLS2_k127_4941051_29 transcriptional regulators - - - 0.0000000000000000000004685 106.0
TLS2_k127_4941051_3 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005266 456.0
TLS2_k127_4941051_30 Alpha beta hydrolase K00433 - 1.11.1.10 0.000000000000000000007073 102.0
TLS2_k127_4941051_31 negative regulation of transcription, DNA-templated K10947 - - 0.000000000000000000629 93.0
TLS2_k127_4941051_32 negative regulation of transcription, DNA-templated - - - 0.000000000000000002481 93.0
TLS2_k127_4941051_33 transcriptional regulators - - - 0.0000000000000001606 92.0
TLS2_k127_4941051_34 Belongs to the peptidase S8 family K13735,K20276,K21449 - - 0.00000000000005946 79.0
TLS2_k127_4941051_35 Gram-negative bacterial TonB protein C-terminal - - - 0.0000000000001857 81.0
TLS2_k127_4941051_36 PFAM Tripartite tricarboxylate transporter TctB family K07794 - - 0.0000000000004351 76.0
TLS2_k127_4941051_37 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000002445 67.0
TLS2_k127_4941051_38 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) K08680 - 4.2.99.20 0.00000003286 61.0
TLS2_k127_4941051_4 PFAM amino acid permease-associated region K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 429.0
TLS2_k127_4941051_5 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 447.0
TLS2_k127_4941051_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 429.0
TLS2_k127_4941051_7 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 414.0
TLS2_k127_4941051_8 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009395 421.0
TLS2_k127_4941051_9 PFAM Tripartite tricarboxylate transporter family receptor K07795 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004418 386.0
TLS2_k127_4942601_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 593.0
TLS2_k127_4942601_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008688 536.0
TLS2_k127_4942601_10 - - - - 0.00000000000000000000000000000000004687 152.0
TLS2_k127_4942601_11 - - - - 0.000000000000000000000000000000001046 141.0
TLS2_k127_4942601_12 Trm112p-like protein K09791 - - 0.00000000000000000008562 90.0
TLS2_k127_4942601_13 Two component regulator propeller - - - 0.00002567 56.0
TLS2_k127_4942601_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 414.0
TLS2_k127_4942601_3 ATP:guanido phosphotransferase, C-terminal catalytic domain K19405 - 2.7.14.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 420.0
TLS2_k127_4942601_4 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006949 311.0
TLS2_k127_4942601_5 Diguanylate cyclase, GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 295.0
TLS2_k127_4942601_6 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001705 249.0
TLS2_k127_4942601_7 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000005869 238.0
TLS2_k127_4942601_8 UvrB/uvrC motif K19411 - - 0.00000000000000000000000000000000000000002637 159.0
TLS2_k127_4942601_9 Clp amino terminal domain, pathogenicity island component K03696 - - 0.00000000000000000000000000000000000006802 147.0
TLS2_k127_49506_0 glutamate catabolic process to 2-oxoglutarate K15371 - 1.4.1.2 0.0 1133.0
TLS2_k127_49506_1 protein histidine kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007194 437.0
TLS2_k127_49506_2 protein conserved in bacteria K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 304.0
TLS2_k127_49506_3 translation initiation inhibitor, yjgF family - - - 0.00000000000000000000000000000003556 133.0
TLS2_k127_49506_4 Putative cyclase - - - 0.000000000000000000000003866 102.0
TLS2_k127_49506_5 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000002759 87.0
TLS2_k127_49506_6 - - - - 0.00000000000001873 82.0
TLS2_k127_49506_7 - - - - 0.00000000007727 70.0
TLS2_k127_4972122_0 Amidohydrolase family - - - 7.08e-235 741.0
TLS2_k127_4972122_1 Amidohydrolase family - - - 5e-225 709.0
TLS2_k127_4972122_10 Gas vesicle - - - 0.0000000000378 73.0
TLS2_k127_4972122_2 Protein conserved in bacteria - - - 7.753e-209 666.0
TLS2_k127_4972122_3 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 575.0
TLS2_k127_4972122_4 Metallopeptidase family M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 380.0
TLS2_k127_4972122_5 PFAM Histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005563 304.0
TLS2_k127_4972122_6 HNH nucleases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002798 257.0
TLS2_k127_4972122_7 Xaa-Pro aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000001097 238.0
TLS2_k127_4972122_8 Yip1 domain - - - 0.000000000000000001879 93.0
TLS2_k127_4972122_9 COG0642 Signal transduction histidine kinase K07647,K07678,K20974 - 2.7.13.3 0.0000000000000006976 79.0
TLS2_k127_4988914_0 Belongs to the UbiD family K03182 - 4.1.1.98 5.157e-288 896.0
TLS2_k127_4988914_1 Dipeptidyl peptidase IV (DPP IV) N-terminal region - - - 2.4e-232 743.0
TLS2_k127_4988914_2 antiporter K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009146 386.0
TLS2_k127_4988914_3 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 343.0
TLS2_k127_4988914_4 Serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000002386 222.0
TLS2_k127_4988914_5 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000000000000004374 214.0
TLS2_k127_5017368_0 synthase K00705,K06044 GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 3.238e-195 640.0
TLS2_k127_5017368_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 5.048e-194 611.0
TLS2_k127_5017368_2 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 343.0
TLS2_k127_5020540_0 Na H antiporter K05559 - - 1.273e-308 971.0
TLS2_k127_5020540_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 3.066e-261 811.0
TLS2_k127_5020540_10 Multisubunit Na H antiporter MnhC subunit K00340,K05560,K05567 - 1.6.5.3 0.0000000000000000000000000000000000001828 145.0
TLS2_k127_5020540_11 PFAM Na H antiporter subunit K05564 - - 0.0000000000000000000000000000000000008314 143.0
TLS2_k127_5020540_12 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05563 - - 0.0000000000000000000000001188 118.0
TLS2_k127_5020540_13 Cytochrome C and Quinol oxidase polypeptide I K15862 - 1.9.3.1 0.0000000000000000000000001567 113.0
TLS2_k127_5020540_14 - - - - 0.0000000000000000005945 95.0
TLS2_k127_5020540_15 - - - - 0.0000000000000000006931 94.0
TLS2_k127_5020540_16 CopC domain K07156 - - 0.000000000000008413 81.0
TLS2_k127_5020540_2 NADH dehydrogenase (Quinone) K05561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 490.0
TLS2_k127_5020540_3 Peptidase family M3 K01414 - 3.4.24.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008348 482.0
TLS2_k127_5020540_4 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 365.0
TLS2_k127_5020540_5 Phage tail sheath C-terminal domain K06907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 315.0
TLS2_k127_5020540_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 299.0
TLS2_k127_5020540_7 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000005365 210.0
TLS2_k127_5020540_8 Cytochrome C and Quinol oxidase polypeptide I - - - 0.0000000000000000000000000000000000000000000000001592 182.0
TLS2_k127_5020540_9 antiporter K05562,K05569 - - 0.000000000000000000000000000000000000000000001562 170.0
TLS2_k127_5083245_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 3.331e-287 897.0
TLS2_k127_5083245_1 Adenylate - - - 2.34e-210 696.0
TLS2_k127_5083245_2 membrane organization - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009697 411.0
TLS2_k127_5083245_3 Monosaccharide ABC transporter ATP-binding protein, CUT2 family K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000075 352.0
TLS2_k127_5083245_4 COG1172 Ribose xylose arabinose galactoside ABC-type transport systems, permease components K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008982 338.0
TLS2_k127_5083245_5 Periplasmic binding protein domain K02058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 323.0
TLS2_k127_5083245_6 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001226 245.0
TLS2_k127_5083245_7 SMART Metal-dependent phosphohydrolase, HD region - - - 0.0000000000000000000000000000000000000000000000000000000001528 214.0
TLS2_k127_5083245_8 SdiA-regulated - - - 0.000000000000000000000000000000000002488 151.0
TLS2_k127_512319_0 efflux transmembrane transporter activity - - - 1.507e-319 1004.0
TLS2_k127_512319_1 efflux transmembrane transporter activity - - - 2.157e-305 960.0
TLS2_k127_512319_10 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004585 314.0
TLS2_k127_512319_11 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001925 256.0
TLS2_k127_512319_12 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002975 258.0
TLS2_k127_512319_13 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002795 266.0
TLS2_k127_512319_14 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000007231 250.0
TLS2_k127_512319_15 COG3911 Predicted ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000008357 235.0
TLS2_k127_512319_16 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000005091 245.0
TLS2_k127_512319_17 Membrane protease subunits, stomatin prohibitin homologs - - - 0.0000000000000000000000000000000000000000000000000000003229 206.0
TLS2_k127_512319_18 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.00000000000000000000000000000000000000000000000001744 195.0
TLS2_k127_512319_19 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000000000000007507 182.0
TLS2_k127_512319_2 PFAM Dynamin family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007813 623.0
TLS2_k127_512319_20 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000001758 169.0
TLS2_k127_512319_21 Bacterial-like globin K06886 - - 0.000000000000000000000000000000000000000000001276 168.0
TLS2_k127_512319_22 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000002711 147.0
TLS2_k127_512319_23 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000001537 152.0
TLS2_k127_512319_24 PIN domain - - - 0.00000000000000000009447 96.0
TLS2_k127_512319_25 Gram-negative bacterial TonB protein C-terminal - - - 0.000000000000003496 86.0
TLS2_k127_512319_26 efflux transmembrane transporter activity - - - 0.0000000000006473 69.0
TLS2_k127_512319_27 negative regulation of transcription, DNA-templated - - - 0.000000000003843 70.0
TLS2_k127_512319_28 positive regulation of growth - - - 0.000000000003871 69.0
TLS2_k127_512319_29 helix_turn_helix, mercury resistance - - - 0.00000002656 59.0
TLS2_k127_512319_3 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 509.0
TLS2_k127_512319_31 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.00005842 50.0
TLS2_k127_512319_32 - - - - 0.0002093 49.0
TLS2_k127_512319_4 FAD-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 475.0
TLS2_k127_512319_5 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 428.0
TLS2_k127_512319_6 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 408.0
TLS2_k127_512319_7 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 390.0
TLS2_k127_512319_8 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 391.0
TLS2_k127_512319_9 Protein of unknown function (DUF1207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008509 359.0
TLS2_k127_5199798_0 PFAM Bile acid sodium symporter K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 570.0
TLS2_k127_5199798_1 peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007306 535.0
TLS2_k127_5199798_10 COG0367 Asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.00000000000000000000000000000000000003009 164.0
TLS2_k127_5199798_11 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.0000000000000000000000000000000001157 137.0
TLS2_k127_5199798_12 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000009109 129.0
TLS2_k127_5199798_13 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000001342 116.0
TLS2_k127_5199798_14 DoxX K15977 - - 0.00000000000000000000000001325 115.0
TLS2_k127_5199798_15 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.000000000000000000000008344 106.0
TLS2_k127_5199798_16 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.00000000000000000001225 104.0
TLS2_k127_5199798_17 Bacterial transcriptional activator domain - - - 0.000000000005649 73.0
TLS2_k127_5199798_19 Transglutaminase-like superfamily - - - 0.0000000004015 66.0
TLS2_k127_5199798_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 451.0
TLS2_k127_5199798_3 Hypothetical methyltransferase K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004043 383.0
TLS2_k127_5199798_4 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006437 361.0
TLS2_k127_5199798_5 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006522 298.0
TLS2_k127_5199798_6 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002557 261.0
TLS2_k127_5199798_7 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000004028 237.0
TLS2_k127_5199798_8 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000004899 219.0
TLS2_k127_5199798_9 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000000000005577 171.0
TLS2_k127_5203585_0 ABC1 family K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007689 567.0
TLS2_k127_5203585_1 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008367 563.0
TLS2_k127_5203585_2 Alpha/beta hydrolase family K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003799 416.0
TLS2_k127_5203585_3 KR domain K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000000000000000000005922 212.0
TLS2_k127_5203585_4 - - - - 0.00000000000000000000000000000000000486 149.0
TLS2_k127_5203585_5 PRC-barrel domain - - - 0.000000000000000000000000001402 120.0
TLS2_k127_5203585_6 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000000007092 100.0
TLS2_k127_5203585_7 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000001111 64.0
TLS2_k127_5219295_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 590.0
TLS2_k127_5219295_1 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005781 425.0
TLS2_k127_5219295_10 - - - - 0.00000000002543 75.0
TLS2_k127_5219295_12 Tetratricopeptide repeat K01768 - 4.6.1.1 0.0000005483 56.0
TLS2_k127_5219295_13 hydrolase of the alpha beta superfamily K07017 - - 0.000001546 54.0
TLS2_k127_5219295_14 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0004623 46.0
TLS2_k127_5219295_2 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000000000003214 194.0
TLS2_k127_5219295_3 Psort location Cytoplasmic, score 8.87 - - - 0.00000000000000000000000000000000000000000000003054 186.0
TLS2_k127_5219295_4 nuclease activity K18828 - - 0.0000000000000000000000000000000000000006979 152.0
TLS2_k127_5219295_5 SMP-30/Gluconolaconase/LRE-like region - - - 0.00000000000000000000000000000000000005187 152.0
TLS2_k127_5219295_6 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.000000000000000000005589 99.0
TLS2_k127_5219295_7 Haem-degrading - - - 0.00000000000000000004489 96.0
TLS2_k127_5219295_8 - - - - 0.000000000001442 79.0
TLS2_k127_5219295_9 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000004207 72.0
TLS2_k127_5220674_0 MacB-like periplasmic core domain - - - 6.19e-273 863.0
TLS2_k127_5220674_1 PhoD-like phosphatase, N-terminal domain K01113 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009501 597.0
TLS2_k127_5220674_10 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003106 259.0
TLS2_k127_5220674_11 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001091 245.0
TLS2_k127_5220674_12 Di-haem oxidoreductase, putative peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000358 239.0
TLS2_k127_5220674_13 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000007424 227.0
TLS2_k127_5220674_14 Protein of unknown function, DUF480 K09915 - - 0.0000000000000000000000000000000000000000000000000000000002171 209.0
TLS2_k127_5220674_15 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000002939 192.0
TLS2_k127_5220674_16 ABC transporter transmembrane region K06147 - - 0.00000000000000000000000000000000000000000000001234 185.0
TLS2_k127_5220674_17 Thioesterase - - - 0.000000000000000000000000000000000000000000001257 174.0
TLS2_k127_5220674_18 ABC transporter transmembrane region K06147 - - 0.00000000000000000000000000000007071 138.0
TLS2_k127_5220674_19 - - - - 0.0000000000000000000000000000001931 140.0
TLS2_k127_5220674_2 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008262 607.0
TLS2_k127_5220674_20 YjbR - - - 0.00000000000000000000000000004459 121.0
TLS2_k127_5220674_21 PFAM transcriptional regulator PadR family protein - - - 0.0000000000000000000000000001428 118.0
TLS2_k127_5220674_22 Acetyltransferase (GNAT) domain K03817 - - 0.0000000000000000000000001575 116.0
TLS2_k127_5220674_23 DinB family - - - 0.0000000000000000000001516 103.0
TLS2_k127_5220674_24 Transcriptional regulator PadR-like family - - - 0.000000000000000008536 91.0
TLS2_k127_5220674_25 - - - - 0.0000000009116 68.0
TLS2_k127_5220674_26 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.000000001932 63.0
TLS2_k127_5220674_27 cell adhesion involved in biofilm formation - - - 0.000000006366 69.0
TLS2_k127_5220674_28 Transcriptional regulatory protein, C terminal - - - 0.00000003274 62.0
TLS2_k127_5220674_3 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004804 560.0
TLS2_k127_5220674_4 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 576.0
TLS2_k127_5220674_5 Lecithin:cholesterol acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 426.0
TLS2_k127_5220674_6 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000779 326.0
TLS2_k127_5220674_7 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 304.0
TLS2_k127_5220674_8 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003312 273.0
TLS2_k127_5220674_9 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005928 261.0
TLS2_k127_5239975_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 550.0
TLS2_k127_5239975_1 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 511.0
TLS2_k127_5239975_10 PFAM transglutaminase domain protein - - - 0.00000000000000000000000000000000000000000000000000005134 206.0
TLS2_k127_5239975_11 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000001006 190.0
TLS2_k127_5239975_12 synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000000008447 169.0
TLS2_k127_5239975_13 Pfam Amidohydrolase K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000484 170.0
TLS2_k127_5239975_14 Protein of unknown function (DUF445) - - - 0.000000000000000000000000000000000001221 158.0
TLS2_k127_5239975_15 CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000000000002655 130.0
TLS2_k127_5239975_16 Tetratricopeptide repeat - - - 0.0000000000000000000000000000004907 135.0
TLS2_k127_5239975_17 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000005073 135.0
TLS2_k127_5239975_18 PFAM 6-pyruvoyl tetrahydropterin K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000254 124.0
TLS2_k127_5239975_19 PFAM thioesterase superfamily protein K07107 - - 0.000000000000000000001563 99.0
TLS2_k127_5239975_2 Putative ATP-binding cassette K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 472.0
TLS2_k127_5239975_20 redox protein regulator of disulfide bond formation K07397 - - 0.0000000000000002525 88.0
TLS2_k127_5239975_21 Macro domain - - - 0.000000000001403 76.0
TLS2_k127_5239975_22 Protein conserved in bacteria - - - 0.000000000003316 77.0
TLS2_k127_5239975_23 Tetratricopeptide repeat - - - 0.00000000000959 75.0
TLS2_k127_5239975_24 Peptidase, M23 K21471 - - 0.00000000006784 76.0
TLS2_k127_5239975_25 Protein of unknown function (DUF1698) - - - 0.00004157 53.0
TLS2_k127_5239975_3 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 389.0
TLS2_k127_5239975_4 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 359.0
TLS2_k127_5239975_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 301.0
TLS2_k127_5239975_6 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001064 293.0
TLS2_k127_5239975_7 GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000002493 269.0
TLS2_k127_5239975_8 synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000003888 236.0
TLS2_k127_5239975_9 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000001693 212.0
TLS2_k127_5278233_0 X-Pro dipeptidyl-peptidase (S15 family) - - - 2.29e-220 704.0
TLS2_k127_5278233_1 LytB protein K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 497.0
TLS2_k127_5278233_10 FAD binding domain K11472 - - 0.0000000000000000000000000000000000001255 157.0
TLS2_k127_5278233_11 pfam gaf K08968 - 1.8.4.14 0.000000000000000000000000003918 116.0
TLS2_k127_5278233_12 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000204 109.0
TLS2_k127_5278233_2 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 460.0
TLS2_k127_5278233_3 Aldo keto - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 433.0
TLS2_k127_5278233_4 PFAM peptidase M18 aminopeptidase I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 434.0
TLS2_k127_5278233_5 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 424.0
TLS2_k127_5278233_6 Rhodanese-like domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 375.0
TLS2_k127_5278233_7 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000001514 201.0
TLS2_k127_5278233_8 Putative cyclase K07130 GO:0003674,GO:0003824,GO:0004061,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 0.0000000000000000000000000000000000000000000000003848 183.0
TLS2_k127_5278233_9 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000002785 176.0
TLS2_k127_5292350_0 Sodium:solute symporter family - - - 9.176e-258 808.0
TLS2_k127_5292350_1 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 330.0
TLS2_k127_5292350_2 Protein of unknown function (DUF1499) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002569 247.0
TLS2_k127_5292350_3 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000001343 227.0
TLS2_k127_5292350_4 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02843,K02849 - - 0.0000000000000000000000000000000000000000000000000000000000001634 227.0
TLS2_k127_5292350_5 hydrolase activity, acting on ester bonds K01563 - 3.8.1.5 0.000000000000000000000000000000000000000000000000000001198 201.0
TLS2_k127_5292350_6 EVE domain - - - 0.000000000000000000000000000000000000000000000000002316 189.0
TLS2_k127_5292350_7 Methyl-transferase - - - 0.000000000000000000000000000000000000000000000006423 176.0
TLS2_k127_5292350_8 alpha beta hydrolase fold - - - 0.00000000000000000000003195 109.0
TLS2_k127_5292350_9 6-phosphogluconolactonase activity - - - 0.0003238 51.0
TLS2_k127_5299750_0 4Fe-4S dicluster domain K00184 - - 8.2e-291 924.0
TLS2_k127_5299750_1 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 606.0
TLS2_k127_5299750_10 Protein of unknown function (DUF3341) - - - 0.0000000000000000000000000000001615 135.0
TLS2_k127_5299750_11 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000427 126.0
TLS2_k127_5299750_12 PFAM glycoside hydrolase family 13 domain protein - - - 0.0000000000000000000001694 108.0
TLS2_k127_5299750_13 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000421 110.0
TLS2_k127_5299750_14 - - - - 0.0000000000000004619 82.0
TLS2_k127_5299750_2 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000772 473.0
TLS2_k127_5299750_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006121 411.0
TLS2_k127_5299750_4 Cytochrome c7 and related cytochrome c K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.00000000000000000000000000000000000000000000000000000000000000000001156 239.0
TLS2_k127_5299750_5 membrane - - - 0.00000000000000000000000000000000000000000000000000000001155 201.0
TLS2_k127_5299750_6 - - - - 0.0000000000000000000000000000000000000000000000000001142 200.0
TLS2_k127_5299750_7 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.0000000000000000000000000000000000000000000000004542 190.0
TLS2_k127_5299750_8 Protein of unknown function (DUF3014) - - - 0.00000000000000000000000000000000000000000009919 170.0
TLS2_k127_5299750_9 Domain of unknown function (DUF892) - - - 0.000000000000000000000000000000000000000001674 165.0
TLS2_k127_5306908_0 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 493.0
TLS2_k127_5306908_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000004778 290.0
TLS2_k127_5306908_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000003466 233.0
TLS2_k127_5306908_3 - - - - 0.0000000000000000000000000000000000000000000000000000000002832 227.0
TLS2_k127_5306908_4 Protein of unknown function (DUF998) - - - 0.0000000000000000000000000000000000000000000000000000004045 202.0
TLS2_k127_5306908_5 DoxX - - - 0.00000000000000000000000004019 119.0
TLS2_k127_5306908_6 serine-type peptidase activity K01990,K08884,K12132,K18912 - 1.14.99.50,2.7.11.1 0.0001178 46.0
TLS2_k127_5316937_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 2.264e-233 736.0
TLS2_k127_5316937_1 Amidohydrolase family - - - 2.816e-228 722.0
TLS2_k127_5316937_10 Cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000761 233.0
TLS2_k127_5316937_11 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000002058 229.0
TLS2_k127_5316937_12 UPF0316 protein - - - 0.00000000000000000000000000000000000000000001852 169.0
TLS2_k127_5316937_13 haloacid dehalogenase-like hydrolase K01079 - 3.1.3.3 0.00000000000000000000000000000000000001042 155.0
TLS2_k127_5316937_14 domain, Protein - - - 0.0000000000000000000000000000000004375 152.0
TLS2_k127_5316937_15 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000306 104.0
TLS2_k127_5316937_16 Protein of unknown function (DUF1207) - - - 0.00000000000000002428 93.0
TLS2_k127_5316937_17 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.00000000000000002793 85.0
TLS2_k127_5316937_18 Regulator of chromosome condensation (RCC1) repeat - - - 0.0000000000001141 85.0
TLS2_k127_5316937_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 529.0
TLS2_k127_5316937_3 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 513.0
TLS2_k127_5316937_4 Peptidase family S58 K01266 - 3.4.11.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 439.0
TLS2_k127_5316937_5 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 433.0
TLS2_k127_5316937_6 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 407.0
TLS2_k127_5316937_7 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 374.0
TLS2_k127_5316937_8 Family of unknown function (DUF1028) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000626 349.0
TLS2_k127_5316937_9 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001537 268.0
TLS2_k127_5335566_0 CHAT domain - - - 3.745e-311 990.0
TLS2_k127_5335566_1 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 451.0
TLS2_k127_5335566_2 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 445.0
TLS2_k127_5335566_3 PFAM DGPFAETKE family protein - - - 0.000000000000000000000000000000000000000000000000005005 190.0
TLS2_k127_5335566_4 Protein of unknown function (DUF3667) - - - 0.0000000000000000000000000000000000000000000073 174.0
TLS2_k127_5335566_7 lipolytic protein G-D-S-L family - - - 0.0000000000009515 80.0
TLS2_k127_5335566_8 - - - - 0.000000000001224 80.0
TLS2_k127_5335566_9 Glycosyl transferases group 1 - - - 0.00001975 47.0
TLS2_k127_5406436_0 Penicillin amidase K01434,K07116 - 3.5.1.11,3.5.1.97 3.597e-237 758.0
TLS2_k127_5406436_1 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 320.0
TLS2_k127_5406436_2 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002266 301.0
TLS2_k127_5406436_3 UPF0056 membrane protein K05595 - - 0.000000000000000000000000000000000000001412 156.0
TLS2_k127_5406436_4 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000003909 149.0
TLS2_k127_5406436_5 Ribosomal protein L11 methyltransferase (PrmA) - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010565,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031974,GO:0031998,GO:0031999,GO:0032259,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0043467,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050994,GO:0050995,GO:0051341,GO:0051354,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1904732,GO:1904733,GO:1904735,GO:1904736 - 0.0000000000000000000000000000000000002895 153.0
TLS2_k127_5406436_6 Endoribonuclease L-PSP - - - 0.00000000000000000000000000001299 126.0
TLS2_k127_5406436_7 Cysteine-rich secretory protein family - - - 0.000000000001328 78.0
TLS2_k127_5406436_8 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.00001129 57.0
TLS2_k127_5428992_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 5.61e-263 833.0
TLS2_k127_5428992_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 572.0
TLS2_k127_5428992_10 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000002494 124.0
TLS2_k127_5428992_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004316 477.0
TLS2_k127_5428992_3 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000368 481.0
TLS2_k127_5428992_4 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 474.0
TLS2_k127_5428992_5 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000778 442.0
TLS2_k127_5428992_6 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005067 414.0
TLS2_k127_5428992_7 Phage integrase, N-terminal SAM-like domain K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008385 328.0
TLS2_k127_5428992_8 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000001735 237.0
TLS2_k127_5428992_9 Probable molybdopterin binding domain K03831 - 2.7.7.75 0.0000000000000000000000000000000000000000001781 165.0
TLS2_k127_5538294_0 Putative modulator of DNA gyrase K03568 - - 1.949e-218 691.0
TLS2_k127_5538294_1 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009717 567.0
TLS2_k127_5538294_10 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008274 309.0
TLS2_k127_5538294_11 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001347 290.0
TLS2_k127_5538294_12 Domain of unknown function (DUF389) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003024 270.0
TLS2_k127_5538294_13 Transcriptional regulatory protein, C terminal K07665 - - 0.000000000000000000000000000000000000000000000000000000000000000002871 235.0
TLS2_k127_5538294_14 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000003725 202.0
TLS2_k127_5538294_15 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000007247 196.0
TLS2_k127_5538294_16 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000001819 189.0
TLS2_k127_5538294_17 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000006593 164.0
TLS2_k127_5538294_18 Protein of unknown function DUF126 K09128 - - 0.000000000000000000000000000000001395 136.0
TLS2_k127_5538294_19 YtkA-like - - - 0.00000000000000000000000000001315 124.0
TLS2_k127_5538294_2 electron transfer activity K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 511.0
TLS2_k127_5538294_20 Heparinase II/III-like protein - - - 0.0000000000000000000000000004475 130.0
TLS2_k127_5538294_21 Clp amino terminal domain, pathogenicity island component K03696 - - 0.00000000000000000000000003867 119.0
TLS2_k127_5538294_22 Belongs to the bacterial solute-binding protein 9 family - - - 0.0000000000000000000000005096 123.0
TLS2_k127_5538294_23 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.00000000000000000000002146 106.0
TLS2_k127_5538294_24 Transcriptional regulator - - - 0.00000000000000003107 93.0
TLS2_k127_5538294_26 Prokaryotic N-terminal methylation motif K02456 - - 0.00004144 52.0
TLS2_k127_5538294_27 - - - - 0.0009777 52.0
TLS2_k127_5538294_3 Putative modulator of DNA gyrase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 486.0
TLS2_k127_5538294_4 TIGRFAM para-aminobenzoate synthase, subunit I K01665,K03342 - 2.6.1.85,4.1.3.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008102 484.0
TLS2_k127_5538294_5 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 449.0
TLS2_k127_5538294_6 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 401.0
TLS2_k127_5538294_7 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 370.0
TLS2_k127_5538294_8 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008774 337.0
TLS2_k127_5538294_9 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004956 314.0
TLS2_k127_5539968_0 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009394 430.0
TLS2_k127_5539968_1 Peroxisomal (S)-2-hydroxy-acid oxidase K11517 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009484 341.0
TLS2_k127_5539968_2 Rad51 K08482 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 299.0
TLS2_k127_5539968_3 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000001632 248.0
TLS2_k127_5539968_4 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000009775 220.0
TLS2_k127_5539968_5 Histidine kinase - - - 0.000000000000000002635 89.0
TLS2_k127_5539968_6 - - - - 0.0001242 53.0
TLS2_k127_5571734_0 4Fe-4S single cluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 519.0
TLS2_k127_5571734_1 Fad linked oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 500.0
TLS2_k127_5571734_10 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 317.0
TLS2_k127_5571734_11 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 315.0
TLS2_k127_5571734_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000001382 259.0
TLS2_k127_5571734_13 Flavin-binding monooxygenase-like K07222 - - 0.000000000000000000000000000000000000000000000000000000000000003049 235.0
TLS2_k127_5571734_14 tRNA wobble adenosine to inosine editing - - - 0.000000000000000000000000000000000000000000000000000000001118 213.0
TLS2_k127_5571734_15 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000002137 199.0
TLS2_k127_5571734_16 DinB family - - - 0.0000000000000000000000000000000000000000000000000001894 192.0
TLS2_k127_5571734_17 gluconolactonase activity K01053,K13735 - 3.1.1.17 0.0000000000000000000000000000000000000000000000003847 197.0
TLS2_k127_5571734_18 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000009879 186.0
TLS2_k127_5571734_19 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000005085 178.0
TLS2_k127_5571734_2 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 512.0
TLS2_k127_5571734_20 Quinohemoprotein amine dehydrogenase, gamma subunit - - - 0.000000000000000000000000000000000000000000001211 174.0
TLS2_k127_5571734_21 Glycosyl transferase 4-like domain K01181,K13668 - 2.4.1.346,3.2.1.8 0.00000000000000000000000000000000000000000001515 180.0
TLS2_k127_5571734_22 Platelet-activating factor acetylhydrolase, isoform II - - - 0.00000000000000000000000000000000000000000002914 179.0
TLS2_k127_5571734_23 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.0000000000000000000000000000000000000006573 159.0
TLS2_k127_5571734_24 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000001014 162.0
TLS2_k127_5571734_25 Amidohydrolase family - - - 0.0000000000000000000000000000000009149 133.0
TLS2_k127_5571734_26 phosphorelay signal transduction system - - - 0.0000000000000000000000001427 112.0
TLS2_k127_5571734_27 WD40 repeats - - - 0.000000000000000000415 100.0
TLS2_k127_5571734_28 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.0000000000000000009479 100.0
TLS2_k127_5571734_29 Carboxypeptidase regulatory-like domain - - - 0.000000000000000006471 94.0
TLS2_k127_5571734_3 COG1132 ABC-type multidrug transport system, ATPase and permease components K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 488.0
TLS2_k127_5571734_30 glycosyl transferase family - - - 0.00000000000000001054 98.0
TLS2_k127_5571734_31 negative regulation of transcription, DNA-templated - - - 0.00000000000000003862 89.0
TLS2_k127_5571734_32 - - - - 0.00000000000000007315 90.0
TLS2_k127_5571734_33 DinB superfamily - - - 0.000000000000009994 87.0
TLS2_k127_5571734_34 rho-dependent transcription termination K19000 - - 0.00000000000004151 75.0
TLS2_k127_5571734_35 Putative adhesin - - - 0.0000000000001693 80.0
TLS2_k127_5571734_36 diphthine synthase activity K03086,K06867 - - 0.000000000003174 78.0
TLS2_k127_5571734_4 Quinohemoprotein amine dehydrogenase, alpha subunit domain IV K08685 - 1.4.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006597 435.0
TLS2_k127_5571734_5 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 378.0
TLS2_k127_5571734_6 Thioesterase-like superfamily K10805 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000313 360.0
TLS2_k127_5571734_7 Sodium/calcium exchanger protein K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004159 366.0
TLS2_k127_5571734_8 Beta-lactamase superfamily domain K06136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005482 322.0
TLS2_k127_5571734_9 Domain of unknown function (DUF368) K08974 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 316.0
TLS2_k127_56032_0 B12 binding domain K04034 - 1.21.98.3 4.818e-233 731.0
TLS2_k127_56032_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363 1.7.2.2 4.486e-195 623.0
TLS2_k127_56032_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 332.0
TLS2_k127_56032_3 Methyltransferase small domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006853 288.0
TLS2_k127_56032_4 PFAM NapC NirT cytochrome c family, N-terminal region K15876 - - 0.00000000000000000000000000000000000000000000000000000000000000000002442 240.0
TLS2_k127_56032_5 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000002278 211.0
TLS2_k127_56032_6 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000296 125.0
TLS2_k127_56032_7 Starch synthase catalytic domain - - - 0.0001721 53.0
TLS2_k127_5674165_0 Protein export membrane protein - - - 0.0 1487.0
TLS2_k127_5674165_1 Domain of unknown function (DUF5117) - - - 2.654e-272 861.0
TLS2_k127_5674165_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 554.0
TLS2_k127_5674165_3 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 533.0
TLS2_k127_5674165_4 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000003864 197.0
TLS2_k127_5674165_5 Protein of unknown function (DUF2892) - - - 0.00000000000000000003223 91.0
TLS2_k127_5720012_0 Amidohydrolase family - - - 0.0 1364.0
TLS2_k127_5720012_1 Peptidase S46 - GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009986,GO:0009987,GO:0016020,GO:0016049,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030154,GO:0030312,GO:0030313,GO:0031975,GO:0032502,GO:0033218,GO:0034641,GO:0040007,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048869,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 5.744e-235 749.0
TLS2_k127_5720012_2 adenosylhomocysteine nucleosidase activity K01243 - 3.2.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 604.0
TLS2_k127_5720012_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003231 390.0
TLS2_k127_5720012_4 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.00000000000000000000000000000000000000000006925 168.0
TLS2_k127_5720012_5 Outer membrane protein beta-barrel domain - - - 0.0000201 55.0
TLS2_k127_5743516_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 7.712e-201 641.0
TLS2_k127_5743516_1 isocitrate dehydrogenase activity K00031 GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 567.0
TLS2_k127_5743516_10 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009128 281.0
TLS2_k127_5743516_11 Domain of unknown function (DUF1732) - - - 0.00000000000000000000000000000000000000000000000000000000000001807 226.0
TLS2_k127_5743516_12 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000005249 192.0
TLS2_k127_5743516_13 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.0000000000000000000000000000000000001713 149.0
TLS2_k127_5743516_14 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.0000000000000000000000000000000000002161 143.0
TLS2_k127_5743516_15 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000003485 144.0
TLS2_k127_5743516_16 TonB-dependent Receptor Plug Domain - - - 0.000000000000000009806 98.0
TLS2_k127_5743516_17 Chorismate mutase K00661,K04092,K04093,K04516,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.3.1.79,4.2.1.51,5.4.99.5 0.00000000000000004175 84.0
TLS2_k127_5743516_18 Protein of unknown function (DUF3311) - - - 0.0000415 51.0
TLS2_k127_5743516_2 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 495.0
TLS2_k127_5743516_3 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 432.0
TLS2_k127_5743516_4 UPF0365 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 419.0
TLS2_k127_5743516_5 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 417.0
TLS2_k127_5743516_6 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 355.0
TLS2_k127_5743516_7 citrate synthase K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005876 329.0
TLS2_k127_5743516_8 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445 315.0
TLS2_k127_5743516_9 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007155 302.0
TLS2_k127_5755116_0 protein histidine kinase activity K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 489.0
TLS2_k127_5755116_1 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 285.0
TLS2_k127_5755116_2 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000002179 256.0
TLS2_k127_5755116_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000006094 219.0
TLS2_k127_5755116_4 Acid phosphatase homologues - - - 0.00000000000000000000000000000000000000003489 160.0
TLS2_k127_5755116_5 actin binding - - - 0.000000000000000000000000000000000003531 141.0
TLS2_k127_5755116_6 - - - - 0.000302 48.0
TLS2_k127_5768876_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1112.0
TLS2_k127_5768876_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 3.996e-304 945.0
TLS2_k127_5768876_10 PFAM Formiminotransferase K00603,K01746 - 2.1.2.5,4.3.1.4 0.00000000000000000000000000000000000000000000000000000000000000001903 237.0
TLS2_k127_5768876_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.000000000000000000000000000000000000000000000000000002474 201.0
TLS2_k127_5768876_12 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000001437 194.0
TLS2_k127_5768876_13 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000004431 196.0
TLS2_k127_5768876_14 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000004707 162.0
TLS2_k127_5768876_15 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 0.0000000000000000000000000000000000000000005022 168.0
TLS2_k127_5768876_16 MotA/TolQ/ExbB proton channel family K03562 - - 0.0000000000000000000000000000000000000000006477 167.0
TLS2_k127_5768876_17 OmpA family K03640 - - 0.000000000000000000000000000000006561 135.0
TLS2_k127_5768876_18 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000000000000000000000000001861 124.0
TLS2_k127_5768876_19 PFAM Peptidase M22, glycoprotease K14742 - - 0.0000000000000000000000006626 115.0
TLS2_k127_5768876_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 5.68e-216 692.0
TLS2_k127_5768876_20 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.00000000000000000000006138 105.0
TLS2_k127_5768876_21 Outer membrane lipoprotein K05807,K08309 - - 0.000000000000000000001049 105.0
TLS2_k127_5768876_22 ATPase or kinase K06925 GO:0000166,GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043531,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - 0.00000000000000001522 92.0
TLS2_k127_5768876_23 TonB C terminal K03832 - - 0.00000000000001374 84.0
TLS2_k127_5768876_24 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000007643 82.0
TLS2_k127_5768876_25 positive regulation of growth rate - - - 0.0000000000008207 80.0
TLS2_k127_5768876_3 Aromatic amino acid lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005957 531.0
TLS2_k127_5768876_4 Belongs to the ALAD family K01698 GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 441.0
TLS2_k127_5768876_5 Polyprenyl synthetase K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 362.0
TLS2_k127_5768876_6 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 337.0
TLS2_k127_5768876_7 PFAM Amidohydrolase family K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 340.0
TLS2_k127_5768876_8 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 314.0
TLS2_k127_5768876_9 RadC-like JAB domain K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000002666 237.0
TLS2_k127_5788113_0 efflux transmembrane transporter activity - - - 0.0 1171.0
TLS2_k127_5788113_1 efflux transmembrane transporter activity - - - 1.612e-264 841.0
TLS2_k127_5788113_10 Protein of unknown function (DUF4256) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 289.0
TLS2_k127_5788113_11 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000017 304.0
TLS2_k127_5788113_12 cAMP biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001039 281.0
TLS2_k127_5788113_13 - - - - 0.0000000000000000000000000000000000000000000000000000000001917 220.0
TLS2_k127_5788113_14 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000000000000000000000016 196.0
TLS2_k127_5788113_15 Protein of unknown function (DUF421) - - - 0.00000000000000000000000000000000000000000000000000003598 199.0
TLS2_k127_5788113_16 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.00000000000000000000000000000000000000000000000004424 184.0
TLS2_k127_5788113_17 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000003903 182.0
TLS2_k127_5788113_18 YCII-related domain - - - 0.00000000000000000000000000000000000000000001851 166.0
TLS2_k127_5788113_19 Protein of unknown function (DUF2938) - - - 0.00000000000000000000000000000000000000000002749 168.0
TLS2_k127_5788113_2 Involved in the tonB-independent uptake of proteins - - - 7.637e-197 642.0
TLS2_k127_5788113_20 - - - - 0.00000000000000000000000000000000000000000003764 168.0
TLS2_k127_5788113_21 cytochrome p450 K11987 - 1.14.99.1 0.000000000000000000000000000000000000000006366 159.0
TLS2_k127_5788113_22 Bacterial PH domain - - - 0.00000000000000000000000000000000000004156 151.0
TLS2_k127_5788113_23 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000002162 144.0
TLS2_k127_5788113_24 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000002602 159.0
TLS2_k127_5788113_25 Transcriptional regulator PadR-like family - - - 0.000000000000000000000005308 105.0
TLS2_k127_5788113_26 SnoaL-like polyketide cyclase - - - 0.0000000000000000000001546 103.0
TLS2_k127_5788113_27 Cupin domain - - - 0.0000000000000000000005522 104.0
TLS2_k127_5788113_28 Belongs to the universal stress protein A family - - - 0.00000000000000003506 92.0
TLS2_k127_5788113_29 Carboxypeptidase regulatory-like domain K02014 - - 0.00000000000000003506 92.0
TLS2_k127_5788113_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003474 564.0
TLS2_k127_5788113_30 Predicted membrane protein (DUF2306) - - - 0.000000000000007002 81.0
TLS2_k127_5788113_31 AhpC/TSA family - - - 0.0000000001346 71.0
TLS2_k127_5788113_32 Outer membrane protein beta-barrel family - - - 0.0002034 52.0
TLS2_k127_5788113_4 Peptidase family S41 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008162 535.0
TLS2_k127_5788113_5 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006445 546.0
TLS2_k127_5788113_6 succinyl-diaminopimelate desuccinylase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005732 461.0
TLS2_k127_5788113_7 peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 429.0
TLS2_k127_5788113_8 Sodium:dicarboxylate symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003379 364.0
TLS2_k127_5788113_9 COG1226 Kef-type K transport systems - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007938 329.0
TLS2_k127_5812422_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006496 460.0
TLS2_k127_5812422_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 421.0
TLS2_k127_5812422_10 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000002803 184.0
TLS2_k127_5812422_11 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000001272 185.0
TLS2_k127_5812422_12 Roadblock/LC7 domain - - - 0.000000000000000000000000000000002662 137.0
TLS2_k127_5812422_13 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000005984 120.0
TLS2_k127_5812422_15 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000002687 104.0
TLS2_k127_5812422_16 Uncharacterised protein family UPF0102 K07460 - - 0.00000000000000000000003683 103.0
TLS2_k127_5812422_17 Biotin-lipoyl like K02005 - - 0.00000000001147 67.0
TLS2_k127_5812422_18 - - - - 0.0000000001837 65.0
TLS2_k127_5812422_2 Aminotransferase class-V K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 375.0
TLS2_k127_5812422_3 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 332.0
TLS2_k127_5812422_4 Competence-damaged protein K03742 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 344.0
TLS2_k127_5812422_5 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006056 332.0
TLS2_k127_5812422_6 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 323.0
TLS2_k127_5812422_7 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006115 302.0
TLS2_k127_5812422_8 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006118 267.0
TLS2_k127_5812422_9 GlcNAc-PI de-N-acetylase K01463 - - 0.0000000000000000000000000000000000000000000000000000000000000004254 234.0
TLS2_k127_582621_0 repeat protein - - - 4.776e-218 696.0
TLS2_k127_582621_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007595 467.0
TLS2_k127_582621_2 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 0.0000000000000000000000000000000000000000000000000000000003436 217.0
TLS2_k127_582621_3 Trypsin-like peptidase domain K08372 - - 0.0005741 52.0
TLS2_k127_5833103_0 Amidohydrolase family - - - 0.0 1163.0
TLS2_k127_5833103_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009628 538.0
TLS2_k127_5833103_10 PFAM cyclase family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 395.0
TLS2_k127_5833103_11 ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 394.0
TLS2_k127_5833103_12 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 323.0
TLS2_k127_5833103_13 protoporphyrinogen oxidase K00231 - 1.3.3.15,1.3.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006249 287.0
TLS2_k127_5833103_14 Belongs to the TPP enzyme family K13039 - 4.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007234 271.0
TLS2_k127_5833103_15 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K06034 - 4.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004098 280.0
TLS2_k127_5833103_16 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001941 267.0
TLS2_k127_5833103_17 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002262 250.0
TLS2_k127_5833103_18 Amidinotransferase K01482 - 3.5.3.18 0.000000000000000000000000000000000000000000000000000000000004263 224.0
TLS2_k127_5833103_19 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000001862 211.0
TLS2_k127_5833103_2 PFAM Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 526.0
TLS2_k127_5833103_20 Glycosyltransferase family 87 - - - 0.00000000000000000000000000000000000000000000000000003744 204.0
TLS2_k127_5833103_21 Glycosyltransferase family 87 - - - 0.00000000000000000000000000000000000000000000001171 188.0
TLS2_k127_5833103_22 lysyltransferase activity - - - 0.00000000000000000000000000000000000000000000006378 183.0
TLS2_k127_5833103_23 Shikimate kinase K00851,K00891 - 2.7.1.12,2.7.1.71 0.00000000000000000000000000000000000000003401 158.0
TLS2_k127_5833103_24 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000004361 113.0
TLS2_k127_5833103_25 Metallo-beta-lactamase superfamily - - - 0.000000000000007633 81.0
TLS2_k127_5833103_26 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000004715 63.0
TLS2_k127_5833103_27 - - - - 0.0002702 53.0
TLS2_k127_5833103_3 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006849 528.0
TLS2_k127_5833103_4 Serine carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 520.0
TLS2_k127_5833103_5 Flavin containing amine oxidoreductase K01854 - 5.4.99.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 526.0
TLS2_k127_5833103_6 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 476.0
TLS2_k127_5833103_7 NAD dependent epimerase/dehydratase family K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 446.0
TLS2_k127_5833103_8 DNA polymerase alpha chain like domain K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 448.0
TLS2_k127_5833103_9 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 431.0
TLS2_k127_5850460_0 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K03520 - 1.2.5.3 4.48e-321 1006.0
TLS2_k127_5850460_1 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 557.0
TLS2_k127_5850460_10 FAD dependent oxidoreductase K21061 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 349.0
TLS2_k127_5850460_11 Belongs to the proline racemase family K12658 GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855,GO:0036361,GO:0047580,GO:0047661 5.1.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 335.0
TLS2_k127_5850460_12 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006013 342.0
TLS2_k127_5850460_13 NAD(P)H quinone oxidoreductase, PIG3 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 298.0
TLS2_k127_5850460_14 ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007963 269.0
TLS2_k127_5850460_15 Transcriptional regulator K07013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001895 254.0
TLS2_k127_5850460_16 Bacterial sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000664 236.0
TLS2_k127_5850460_17 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000054 220.0
TLS2_k127_5850460_18 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000008966 222.0
TLS2_k127_5850460_19 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000002449 205.0
TLS2_k127_5850460_2 UDP binding domain K13015 - 1.1.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 519.0
TLS2_k127_5850460_20 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000005153 199.0
TLS2_k127_5850460_21 synthase homocitrate synthase family - - - 0.000000000000000000000000000000000000000000000000003854 198.0
TLS2_k127_5850460_23 Protein of unknown function (DUF1460) - - - 0.0000000000000000000000000000000000000000000000004166 198.0
TLS2_k127_5850460_24 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000001919 184.0
TLS2_k127_5850460_25 Xanthine and CO dehydrogenases maturation factor XdhC CoxF K07402 - - 0.0000000000000000000000000000000003503 147.0
TLS2_k127_5850460_27 Cold shock K03704 - - 0.000000000000000000000000001806 114.0
TLS2_k127_5850460_29 ATP synthesis coupled electron transport K00302 - 1.5.3.1 0.000000000000000001527 90.0
TLS2_k127_5850460_3 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 507.0
TLS2_k127_5850460_30 XdhC and CoxI family - - - 0.0000000000000001794 83.0
TLS2_k127_5850460_31 methylated DNA-protein cysteine methyltransferase K07443 - - 0.0000000000000003307 91.0
TLS2_k127_5850460_32 MobA-like NTP transferase domain K07141,K19190 - 1.1.1.328,2.7.7.76 0.00000000000000824 83.0
TLS2_k127_5850460_33 NUDIX domain - - - 0.000000000001359 79.0
TLS2_k127_5850460_34 Transglycosylase associated protein - - - 0.00003487 52.0
TLS2_k127_5850460_35 - - - - 0.0006113 50.0
TLS2_k127_5850460_4 Belongs to the aldehyde dehydrogenase family K22187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005369 455.0
TLS2_k127_5850460_5 antibiotic catabolic process K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 414.0
TLS2_k127_5850460_6 PFAM sodium calcium exchanger membrane region K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 405.0
TLS2_k127_5850460_7 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 400.0
TLS2_k127_5850460_8 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 374.0
TLS2_k127_5850460_9 Belongs to the DapA family K21062 - 3.5.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 349.0
TLS2_k127_5891_0 COG1283 Na phosphate symporter K03324 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006331 527.0
TLS2_k127_5891_1 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 431.0
TLS2_k127_5891_10 virulence factor MVIN family protein - - - 0.00000000009315 75.0
TLS2_k127_5891_11 Capsule assembly protein Wzi - - - 0.0000000004139 72.0
TLS2_k127_5891_12 polysaccharide export protein K01991 - - 0.00000000182 70.0
TLS2_k127_5891_13 PFAM Chain length determinant protein - - - 0.0000002774 64.0
TLS2_k127_5891_2 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 347.0
TLS2_k127_5891_3 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006928 289.0
TLS2_k127_5891_4 COG2148 Sugar transferases involved in lipopolysaccharide synthesis - - - 0.00000000000000000000000000000000000000000000000000008138 196.0
TLS2_k127_5891_5 carboxymethylenebutenolidase activity K01061,K06889 - 3.1.1.45 0.0000000000000000000000000000000000000000000002021 187.0
TLS2_k127_5891_6 sequence-specific DNA binding K03719 - - 0.0000000000000000000000000000000001846 141.0
TLS2_k127_5891_8 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000001035 103.0
TLS2_k127_5891_9 - - - - 0.0000000000000005633 93.0
TLS2_k127_5909116_0 Tetratricopeptide repeat K12132 - 2.7.11.1 0.0 1056.0
TLS2_k127_5909116_1 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 2.487e-219 690.0
TLS2_k127_5909116_10 - - - - 0.0000000000000000000000000000000000000000000000003029 183.0
TLS2_k127_5909116_11 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000001933 143.0
TLS2_k127_5909116_12 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000000005866 129.0
TLS2_k127_5909116_13 Beta-lactamase - - - 0.000004938 54.0
TLS2_k127_5909116_2 Peptidase family M1 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005002 612.0
TLS2_k127_5909116_3 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 592.0
TLS2_k127_5909116_4 PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 530.0
TLS2_k127_5909116_5 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 351.0
TLS2_k127_5909116_6 Ankyrin repeats (many copies) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004485 295.0
TLS2_k127_5909116_7 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001598 242.0
TLS2_k127_5909116_8 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000002314 228.0
TLS2_k127_5909116_9 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000002679 184.0
TLS2_k127_5933475_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 479.0
TLS2_k127_5933475_1 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 399.0
TLS2_k127_5933475_10 Cephalosporin hydroxylase - - - 0.000000000000000000000000000000000000000000000000000002767 199.0
TLS2_k127_5933475_11 Core-2 I-Branching enzyme K00771 - 2.4.2.26 0.00000000000000000000000000000000000000000000000002862 199.0
TLS2_k127_5933475_12 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000006363 188.0
TLS2_k127_5933475_13 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000009479 108.0
TLS2_k127_5933475_2 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009357 424.0
TLS2_k127_5933475_3 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007611 386.0
TLS2_k127_5933475_4 Glycosyl transferase family group 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 327.0
TLS2_k127_5933475_5 Glycosyltransferase family 87 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009544 275.0
TLS2_k127_5933475_6 Phage integrase, N-terminal SAM-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001468 254.0
TLS2_k127_5933475_7 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000169 248.0
TLS2_k127_5933475_8 NAD+ binding - - - 0.00000000000000000000000000000000000000000000000000000000000006004 229.0
TLS2_k127_5933475_9 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000002464 210.0
TLS2_k127_6065003_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006428 542.0
TLS2_k127_6065003_1 UDP-N-acetylglucosamine 2-epimerase K18429 - 3.2.1.184 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 513.0
TLS2_k127_6065003_10 Peptidase family M23 K21472 - - 0.00000000000001148 81.0
TLS2_k127_6065003_2 COG2089 Sialic acid synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 488.0
TLS2_k127_6065003_3 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 482.0
TLS2_k127_6065003_4 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007689 431.0
TLS2_k127_6065003_5 mechanosensitive ion channel K16052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 355.0
TLS2_k127_6065003_6 Peptidase family M23 K21472 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006055 347.0
TLS2_k127_6065003_7 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000001169 193.0
TLS2_k127_6065003_8 IMP dehydrogenase activity K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000003484 111.0
TLS2_k127_6065003_9 negative regulation of transcription, DNA-templated - - - 0.000000000000000000264 94.0
TLS2_k127_607266_0 cellulose binding - - - 0.0 1068.0
TLS2_k127_607266_1 Pfam Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 338.0
TLS2_k127_607266_2 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000004375 173.0
TLS2_k127_607266_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000003876 156.0
TLS2_k127_6135162_0 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 3.18e-223 707.0
TLS2_k127_6135162_1 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.00000000000000000000000000000000000000000000000000000000000001056 228.0
TLS2_k127_6135162_2 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000005009 156.0
TLS2_k127_6135162_3 Protein of unknown function (DUF1697) - - - 0.000000000000000000000000000000000009886 143.0
TLS2_k127_6135162_4 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000001327 137.0
TLS2_k127_6185326_0 Carbamoyltransferase C-terminus K00612 - - 3.123e-310 960.0
TLS2_k127_6185326_1 His Kinase A (phosphoacceptor) domain - - - 2.878e-299 948.0
TLS2_k127_6185326_10 - - - - 0.000000000004494 74.0
TLS2_k127_6185326_11 multicopper - - - 0.000000000007837 72.0
TLS2_k127_6185326_12 SusD family K21572 - - 0.000000001819 68.0
TLS2_k127_6185326_13 nodulation - - - 0.0000004367 57.0
TLS2_k127_6185326_2 CarboxypepD_reg-like domain - - - 1.659e-225 735.0
TLS2_k127_6185326_3 histone deacetylase K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003022 395.0
TLS2_k127_6185326_4 PFAM blue (type 1) copper domain protein K00368,K02638 - 1.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000009851 267.0
TLS2_k127_6185326_5 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.000000000000000000000000000000000000000000000001091 183.0
TLS2_k127_6185326_6 sequence-specific DNA binding K03719 - - 0.000000000000000000000000000000000000000000002916 169.0
TLS2_k127_6185326_7 RES - - - 0.000000000000000000000003004 110.0
TLS2_k127_6185326_8 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000002957 106.0
TLS2_k127_6185326_9 GDSL-like Lipase/Acylhydrolase family - - - 0.000000000000000001634 98.0
TLS2_k127_6213063_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 1.004e-257 822.0
TLS2_k127_6213063_1 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 574.0
TLS2_k127_6213063_10 ZIP Zinc transporter K07238,K11021,K16267 - - 0.000000000000000000000000000000000000000000000001437 183.0
TLS2_k127_6213063_11 NADP oxidoreductase coenzyme F420-dependent - - - 0.0000000000000000000000000000000000000000831 163.0
TLS2_k127_6213063_12 Late embryogenesis abundant protein - - - 0.000000000000008732 84.0
TLS2_k127_6213063_13 - - - - 0.0005274 50.0
TLS2_k127_6213063_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 461.0
TLS2_k127_6213063_3 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004926 297.0
TLS2_k127_6213063_4 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007583 303.0
TLS2_k127_6213063_5 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000124 282.0
TLS2_k127_6213063_6 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000008576 214.0
TLS2_k127_6213063_7 SIS domain K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000002426 203.0
TLS2_k127_6213063_8 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000000000000003765 212.0
TLS2_k127_6213063_9 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000002875 190.0
TLS2_k127_6213376_0 Amidohydrolase family - - - 0.0 1127.0
TLS2_k127_6213376_1 Dipeptidyl peptidase IV (DPP IV) N-terminal region - - - 9.718e-300 943.0
TLS2_k127_6213376_10 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000000000000000000001011 231.0
TLS2_k127_6213376_11 - - - - 0.000000000000000000000000000000000000000000000000000000006351 205.0
TLS2_k127_6213376_13 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000303 164.0
TLS2_k127_6213376_14 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000001422 132.0
TLS2_k127_6213376_15 - - - - 0.00000000000000000000001222 115.0
TLS2_k127_6213376_16 - - - - 0.00000000000000000000005033 106.0
TLS2_k127_6213376_17 Domain of unknown function (DUF4142) K08995 - - 0.00000000000000000006662 98.0
TLS2_k127_6213376_18 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000003907 88.0
TLS2_k127_6213376_19 Glycogen recognition site of AMP-activated protein kinase - - - 0.00000000000003016 79.0
TLS2_k127_6213376_2 Belongs to the glycosyl hydrolase 2 family - - - 3.04e-268 838.0
TLS2_k127_6213376_20 Domain of unknown function (DUF4118) K07646 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 2.7.13.3 0.00000000000009792 83.0
TLS2_k127_6213376_21 Protein kinase domain K12132 - 2.7.11.1 0.000000000003712 77.0
TLS2_k127_6213376_3 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 1.922e-240 755.0
TLS2_k127_6213376_4 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 2.574e-219 721.0
TLS2_k127_6213376_5 N-acetyldiaminopimelate deacetylase activity K12941 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 593.0
TLS2_k127_6213376_6 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004114 534.0
TLS2_k127_6213376_7 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 383.0
TLS2_k127_6213376_8 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 329.0
TLS2_k127_6213376_9 protein required for cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002886 313.0
TLS2_k127_6222532_0 Peptidase M14, carboxypeptidase A - - - 4.908e-254 816.0
TLS2_k127_6222532_1 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000005539 172.0
TLS2_k127_6222532_2 phosphohistidine phosphatase K08296 - - 0.00000000000000000000000000000000000002021 153.0
TLS2_k127_6222532_3 Peptidase family M28 - - - 0.0000000000000000000000000000000003084 132.0
TLS2_k127_6222532_4 Putative lumazine-binding - - - 0.0000000000000000000000000000004532 132.0
TLS2_k127_6222532_5 Helix-turn-helix domain - - - 0.00000000000000000000000000008168 123.0
TLS2_k127_6222532_6 - - - - 0.0000001072 59.0
TLS2_k127_6222532_7 Activator of Hsp90 ATPase - - - 0.0005996 51.0
TLS2_k127_6227096_0 Oligopeptide/dipeptide transporter, C-terminal region K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 451.0
TLS2_k127_6227096_1 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006121 409.0
TLS2_k127_6227096_10 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.00000000000000000000000003726 112.0
TLS2_k127_6227096_12 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.000001536 51.0
TLS2_k127_6227096_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 426.0
TLS2_k127_6227096_3 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007033 360.0
TLS2_k127_6227096_4 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003886 290.0
TLS2_k127_6227096_5 - - - - 0.00000000000000000000000000000000000000000000000000005626 206.0
TLS2_k127_6227096_6 MotA/TolQ/ExbB proton channel family K03561 - - 0.00000000000000000000000000000000000000000000007006 178.0
TLS2_k127_6227096_7 ECF sigma factor - - - 0.00000000000000000000000000000000000000000001986 171.0
TLS2_k127_6227096_8 Tetratricopeptide repeat K08309 - - 0.00000000000000000000000000000000000001253 166.0
TLS2_k127_6227096_9 Cold shock K03704 - - 0.0000000000000000000000000006621 115.0
TLS2_k127_6262877_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1140.0
TLS2_k127_6262877_1 DNA topoisomerase II activity K02469 - 5.99.1.3 9.033e-317 992.0
TLS2_k127_6262877_10 PFAM Alpha beta hydrolase K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009078 296.0
TLS2_k127_6262877_11 PFAM inositol monophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003027 284.0
TLS2_k127_6262877_12 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000436 278.0
TLS2_k127_6262877_13 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001168 278.0
TLS2_k127_6262877_14 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000328 261.0
TLS2_k127_6262877_15 PFAM peptidase S58, DmpA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001683 253.0
TLS2_k127_6262877_16 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000001397 233.0
TLS2_k127_6262877_17 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000001951 230.0
TLS2_k127_6262877_18 Histidine biosynthesis protein K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000006794 220.0
TLS2_k127_6262877_19 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.0000000000000000000000000000000000000000000000000000007947 213.0
TLS2_k127_6262877_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 5.466e-238 762.0
TLS2_k127_6262877_20 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000001206 183.0
TLS2_k127_6262877_21 Histidine biosynthesis bifunctional protein HisIE K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000001394 183.0
TLS2_k127_6262877_22 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000001514 167.0
TLS2_k127_6262877_23 COG1651 Protein-disulfide isomerase - - - 0.0000000000000000000000000000000000002383 150.0
TLS2_k127_6262877_24 Cell wall-active antibiotics response 4TMS YvqF - - - 0.000000000000000000000000000002785 139.0
TLS2_k127_6262877_25 Transglycosylase associated protein - - - 0.00000000000000000000000001697 117.0
TLS2_k127_6262877_26 amine dehydrogenase activity - - - 0.00000001282 67.0
TLS2_k127_6262877_3 (ABC) transporter K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009227 604.0
TLS2_k127_6262877_4 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 580.0
TLS2_k127_6262877_5 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 388.0
TLS2_k127_6262877_6 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 372.0
TLS2_k127_6262877_7 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 363.0
TLS2_k127_6262877_8 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01663,K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 342.0
TLS2_k127_6262877_9 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 304.0
TLS2_k127_6298971_0 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000932 515.0
TLS2_k127_6298971_1 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007287 379.0
TLS2_k127_6298971_2 YCII-related domain - - - 0.000000000000000000000000000000000000002742 151.0
TLS2_k127_6298971_3 YCII-related domain - - - 0.0000000000000000000000003879 109.0
TLS2_k127_6298971_4 helix_turn_helix, Lux Regulon - - - 0.00006128 51.0
TLS2_k127_6300298_0 peptidase S9B dipeptidylpeptidase IV domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 569.0
TLS2_k127_6300298_1 succinyl-diaminopimelate desuccinylase activity K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 481.0
TLS2_k127_6300298_2 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 491.0
TLS2_k127_6300298_3 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000002777 233.0
TLS2_k127_6300298_4 DnaJ molecular chaperone homology domain - - - 0.00000000000000000000000000000000000000000000000006821 186.0
TLS2_k127_6300298_5 Bacterial Ig-like domain 2 - - - 0.00002037 57.0
TLS2_k127_6311449_0 xaa-pro aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 576.0
TLS2_k127_6311449_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 338.0
TLS2_k127_6311449_2 Zinc carboxypeptidase - - - 0.00000000000000000000000003413 110.0
TLS2_k127_6324389_0 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 559.0
TLS2_k127_6324389_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K11928 - - 0.00000000000000000000000000000000000000000000000001209 198.0
TLS2_k127_6324389_2 - - - - 0.00000000000000000000000000000000000000009154 165.0
TLS2_k127_6324389_3 Subtilase family K01361 - 3.4.21.96 0.0000000000000000000000000000000000001685 150.0
TLS2_k127_6324389_4 regulatory protein, arsR - - - 0.0000000000000000000000000000000001222 139.0
TLS2_k127_6324389_5 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000002278 127.0
TLS2_k127_6324389_6 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000002335 97.0
TLS2_k127_6324389_7 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000004481 78.0
TLS2_k127_6324389_8 transcriptional regulator, ArsR family - - - 0.000005493 53.0
TLS2_k127_6335807_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1171.0
TLS2_k127_6335807_1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 2.558e-266 833.0
TLS2_k127_6335807_10 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 364.0
TLS2_k127_6335807_11 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 333.0
TLS2_k127_6335807_12 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 358.0
TLS2_k127_6335807_13 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 323.0
TLS2_k127_6335807_14 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 317.0
TLS2_k127_6335807_15 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 312.0
TLS2_k127_6335807_16 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 305.0
TLS2_k127_6335807_17 Zinc carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 309.0
TLS2_k127_6335807_18 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 288.0
TLS2_k127_6335807_19 Surface antigen K07277,K07278 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001393 301.0
TLS2_k127_6335807_2 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 1.614e-207 681.0
TLS2_k127_6335807_20 DNA topoisomerase type I activity K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000346 273.0
TLS2_k127_6335807_21 TIGRFAM Phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000003991 264.0
TLS2_k127_6335807_22 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001568 262.0
TLS2_k127_6335807_23 PspA/IM30 family K03969 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002056 250.0
TLS2_k127_6335807_24 COG1253 Hemolysins and related proteins containing CBS domains - - - 0.000000000000000000000000000000000000000000000000000000000000003039 242.0
TLS2_k127_6335807_25 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000001376 226.0
TLS2_k127_6335807_26 Beta-lactamase K01256,K17836 - 3.4.11.2,3.5.2.6 0.00000000000000000000000000000000000000000000000000000000001028 232.0
TLS2_k127_6335807_27 Zn peptidase - - - 0.00000000000000000000000000000000000000000000000000000003348 214.0
TLS2_k127_6335807_28 lipid kinase activity - - - 0.00000000000000000000000000000000000000000000003542 181.0
TLS2_k127_6335807_29 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.00000000000000000000000000000000000000000000008178 182.0
TLS2_k127_6335807_3 FAD binding domain of DNA photolyase K01669 - 4.1.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004471 561.0
TLS2_k127_6335807_30 Mannose-6-phosphate isomerase - - - 0.0000000000000000000000000000000000000000004093 161.0
TLS2_k127_6335807_31 Permease - - - 0.00000000000000000000000000000000009796 147.0
TLS2_k127_6335807_32 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950,K09007,K13940,K17488 - 2.7.6.3,3.5.4.16,3.5.4.39,4.1.2.25 0.0000000000000000000000000000000005046 139.0
TLS2_k127_6335807_33 Glutathione peroxidase - - - 0.00000000000000000000000000000001292 134.0
TLS2_k127_6335807_34 - - - - 0.00000000000000000000000000002788 125.0
TLS2_k127_6335807_35 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000002321 94.0
TLS2_k127_6335807_36 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.000000000000008827 83.0
TLS2_k127_6335807_37 Bifunctional sulfur carrier protein thiazole synthase K03154 - - 0.00000000000005145 80.0
TLS2_k127_6335807_38 Evidence 5 No homology to any previously reported sequences - - - 0.000000000414 70.0
TLS2_k127_6335807_4 AMP-binding enzyme C-terminal domain K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 557.0
TLS2_k127_6335807_5 Sodium:solute symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000829 503.0
TLS2_k127_6335807_6 Na+/H+ antiporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007123 473.0
TLS2_k127_6335807_7 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002674 427.0
TLS2_k127_6335807_8 Protein of unknown function (DUF1343) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 394.0
TLS2_k127_6335807_9 OST-HTH/LOTUS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 377.0
TLS2_k127_6367237_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.281e-273 863.0
TLS2_k127_6367237_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 2.495e-214 679.0
TLS2_k127_6388574_0 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009806 552.0
TLS2_k127_6388574_1 COG0656 Aldo keto reductases, related to diketogulonate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 403.0
TLS2_k127_6388574_10 lactoylglutathione lyase activity - - - 0.0000000001756 73.0
TLS2_k127_6388574_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004008 266.0
TLS2_k127_6388574_3 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000002904 249.0
TLS2_k127_6388574_4 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004085 248.0
TLS2_k127_6388574_5 endonuclease activity - - - 0.0000000000000000000000000000000000000000004426 163.0
TLS2_k127_6388574_6 PAS domain containing protein - - - 0.0000000000000000000000000000000000000000569 171.0
TLS2_k127_6388574_7 Redoxin - - - 0.000000000000000000000000000001623 132.0
TLS2_k127_6388574_8 Thioredoxin-like - - - 0.0000000000000000000000000000176 134.0
TLS2_k127_6388574_9 Ankyrin repeats (many copies) - - - 0.0000000001326 74.0
TLS2_k127_6396472_0 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 452.0
TLS2_k127_6396472_1 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 439.0
TLS2_k127_6396472_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000002337 214.0
TLS2_k127_6396472_3 - - - - 0.0000000000000000000000698 103.0
TLS2_k127_6443237_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 556.0
TLS2_k127_6443237_1 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0016874,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009646 530.0
TLS2_k127_6443237_2 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007864 398.0
TLS2_k127_6443237_3 Trypsin K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 374.0
TLS2_k127_6443237_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006361 290.0
TLS2_k127_6443237_5 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000002154 231.0
TLS2_k127_6443237_6 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000002054 81.0
TLS2_k127_6474674_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.676e-266 837.0
TLS2_k127_6474674_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.256e-215 707.0
TLS2_k127_6474674_10 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 470.0
TLS2_k127_6474674_11 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 464.0
TLS2_k127_6474674_12 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 453.0
TLS2_k127_6474674_13 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 430.0
TLS2_k127_6474674_14 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 428.0
TLS2_k127_6474674_15 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 425.0
TLS2_k127_6474674_16 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004196 413.0
TLS2_k127_6474674_17 Cell cycle protein K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 405.0
TLS2_k127_6474674_18 Ribosomal protein S2 K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 327.0
TLS2_k127_6474674_19 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005314 317.0
TLS2_k127_6474674_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 9.544e-214 673.0
TLS2_k127_6474674_20 Nucleotidyl transferase K00971 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 314.0
TLS2_k127_6474674_21 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 306.0
TLS2_k127_6474674_22 Zinc dependent phospholipase C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 306.0
TLS2_k127_6474674_23 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 289.0
TLS2_k127_6474674_24 Sugar nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004694 279.0
TLS2_k127_6474674_25 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000001259 287.0
TLS2_k127_6474674_26 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000599 267.0
TLS2_k127_6474674_27 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001653 253.0
TLS2_k127_6474674_28 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000004694 248.0
TLS2_k127_6474674_29 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009172 242.0
TLS2_k127_6474674_3 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 4.234e-203 663.0
TLS2_k127_6474674_30 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000001335 213.0
TLS2_k127_6474674_31 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000168 220.0
TLS2_k127_6474674_32 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000004108 208.0
TLS2_k127_6474674_33 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177,K03483 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.00000000000000000000000000000000000000000000000000000003349 207.0
TLS2_k127_6474674_34 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.000000000000000000000000000000000000000000000001869 185.0
TLS2_k127_6474674_35 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.0000000000000000000000000000000000000008649 158.0
TLS2_k127_6474674_36 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000001333 156.0
TLS2_k127_6474674_37 rod shape-determining protein MreC K03570 - - 0.000000000000000000000000000000000005379 148.0
TLS2_k127_6474674_38 cheY-homologous receiver domain - - - 0.00000000000000000000000000000583 126.0
TLS2_k127_6474674_39 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000004652 119.0
TLS2_k127_6474674_4 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.288e-197 628.0
TLS2_k127_6474674_40 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000002484 114.0
TLS2_k127_6474674_41 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000003138 96.0
TLS2_k127_6474674_42 protein conserved in bacteria K09764 - - 0.0000000000000002477 81.0
TLS2_k127_6474674_43 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000001683 81.0
TLS2_k127_6474674_44 - - - - 0.000000002515 69.0
TLS2_k127_6474674_45 ribosomal protein - - - 0.0000009179 55.0
TLS2_k127_6474674_5 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 567.0
TLS2_k127_6474674_6 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 550.0
TLS2_k127_6474674_7 Hsp70 protein K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 539.0
TLS2_k127_6474674_8 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 503.0
TLS2_k127_6474674_9 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008544 501.0
TLS2_k127_6583725_0 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000384 641.0
TLS2_k127_6583725_1 DALR_2 K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004544 461.0
TLS2_k127_6583725_2 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000522 413.0
TLS2_k127_6583725_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007289 391.0
TLS2_k127_6583725_4 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 321.0
TLS2_k127_6583725_5 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000403 261.0
TLS2_k127_6583725_6 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000001309 230.0
TLS2_k127_6583725_7 mechanosensitive ion channel K22044 - - 0.0000000000000000000002728 98.0
TLS2_k127_6583725_8 - - - - 0.000000000000000001085 87.0
TLS2_k127_6583725_9 Domain of unknown function (DUF4142) K08995 - - 0.0000000000000001062 89.0
TLS2_k127_6587565_0 peptidase S9B dipeptidylpeptidase IV domain protein - - - 8.698e-302 946.0
TLS2_k127_6587565_1 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 4.013e-296 923.0
TLS2_k127_6587565_10 Spermine/spermidine synthase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005769 336.0
TLS2_k127_6587565_11 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 336.0
TLS2_k127_6587565_12 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 311.0
TLS2_k127_6587565_13 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 314.0
TLS2_k127_6587565_14 PFAM Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 296.0
TLS2_k127_6587565_15 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003174 283.0
TLS2_k127_6587565_16 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001933 253.0
TLS2_k127_6587565_17 chitinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001051 239.0
TLS2_k127_6587565_18 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000003041 237.0
TLS2_k127_6587565_19 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000127 222.0
TLS2_k127_6587565_2 MacB-like periplasmic core domain - - - 1.19e-211 692.0
TLS2_k127_6587565_20 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000000001302 169.0
TLS2_k127_6587565_21 - - - - 0.0000000000000000000000000000000000000000000025 172.0
TLS2_k127_6587565_22 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000000000000000000000000007078 163.0
TLS2_k127_6587565_23 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000859 162.0
TLS2_k127_6587565_24 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000005295 141.0
TLS2_k127_6587565_25 - - - - 0.00000000000000000000000000001045 130.0
TLS2_k127_6587565_26 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.0000000000000000000000000001842 121.0
TLS2_k127_6587565_27 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000006761 125.0
TLS2_k127_6587565_28 Spermine/spermidine synthase domain - - - 0.000000000000000004843 92.0
TLS2_k127_6587565_29 - - - - 0.000000000000008867 78.0
TLS2_k127_6587565_3 PFAM Serine carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 615.0
TLS2_k127_6587565_30 Arylsulfotransferase Ig-like domain K01023 - 2.8.2.22 0.00000000001933 76.0
TLS2_k127_6587565_32 Spermine/spermidine synthase domain - - - 0.000000001458 68.0
TLS2_k127_6587565_33 Protein kinase domain K12132 - 2.7.11.1 0.0003212 53.0
TLS2_k127_6587565_34 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.0008835 51.0
TLS2_k127_6587565_4 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 564.0
TLS2_k127_6587565_5 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004908 515.0
TLS2_k127_6587565_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 443.0
TLS2_k127_6587565_7 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 428.0
TLS2_k127_6587565_8 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008934 397.0
TLS2_k127_6587565_9 Homoserine dehydrogenase, NAD binding domain K18652 - 1.1.1.361 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 372.0
TLS2_k127_6592430_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 603.0
TLS2_k127_6592430_1 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004248 584.0
TLS2_k127_6592430_10 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001237 268.0
TLS2_k127_6592430_11 Dihydrodipicolinate synthetase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000007205 244.0
TLS2_k127_6592430_12 Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000007952 234.0
TLS2_k127_6592430_13 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000001312 208.0
TLS2_k127_6592430_14 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.00000000000000000000000000000000000000000001028 170.0
TLS2_k127_6592430_15 MgtC family K07507 - - 0.00000000000000000000000000000000000000008106 159.0
TLS2_k127_6592430_16 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000004823 114.0
TLS2_k127_6592430_17 negative regulation of transcription, DNA-templated - - - 0.000000000000000000007799 95.0
TLS2_k127_6592430_18 4-vinyl reductase, 4VR - - - 0.0000000000000000002944 97.0
TLS2_k127_6592430_2 Pyrimidine nucleoside phosphorylase C-terminal domain K00756 - 2.4.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 475.0
TLS2_k127_6592430_20 - - - - 0.00001739 51.0
TLS2_k127_6592430_22 YtxH-like protein - - - 0.0003638 46.0
TLS2_k127_6592430_3 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009 498.0
TLS2_k127_6592430_4 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 448.0
TLS2_k127_6592430_5 COG0380 Trehalose-6-phosphate synthase K00697 - 2.4.1.15,2.4.1.347 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005053 446.0
TLS2_k127_6592430_6 Outer membrane protein beta-barrel family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 387.0
TLS2_k127_6592430_7 GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 340.0
TLS2_k127_6592430_8 Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate K00674,K05822 - 2.3.1.117,2.3.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000001404 269.0
TLS2_k127_6592430_9 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000005008 272.0
TLS2_k127_6631635_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000556 634.0
TLS2_k127_6631635_1 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003577 295.0
TLS2_k127_6682302_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 523.0
TLS2_k127_6682302_1 Protein of unknown function (DUF3500) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001951 265.0
TLS2_k127_6682302_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000001448 205.0
TLS2_k127_6682302_3 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000004657 143.0
TLS2_k127_6682302_4 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000001373 143.0
TLS2_k127_6682302_5 protein kinase activity - - - 0.000000049 59.0
TLS2_k127_6763874_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.737e-286 887.0
TLS2_k127_6763874_1 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004766 571.0
TLS2_k127_6763874_10 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000004914 237.0
TLS2_k127_6763874_11 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000001339 223.0
TLS2_k127_6763874_12 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000001939 219.0
TLS2_k127_6763874_14 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000001049 139.0
TLS2_k127_6763874_15 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000006178 142.0
TLS2_k127_6763874_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000735 526.0
TLS2_k127_6763874_3 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 456.0
TLS2_k127_6763874_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 438.0
TLS2_k127_6763874_5 Glycosyl transferase 4-like K00754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 408.0
TLS2_k127_6763874_6 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 402.0
TLS2_k127_6763874_7 PFAM Na Pi-cotransporter K03324 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 370.0
TLS2_k127_6763874_8 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000269 277.0
TLS2_k127_6763874_9 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001544 253.0
TLS2_k127_6779300_0 Amidohydrolase family - - - 0.0 1275.0
TLS2_k127_6779300_1 Pyridoxal-dependent decarboxylase conserved domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008621 410.0
TLS2_k127_6779300_2 Transcription elongation factor, N-terminal K03624 - - 0.00000000000000000000000000000000000000005357 158.0
TLS2_k127_6779300_3 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000000000000000000000002703 125.0
TLS2_k127_6779300_4 response to hydrogen peroxide K08985 - - 0.0000000000000000000309 101.0
TLS2_k127_6779300_5 PGAP1-like protein - - - 0.0000000000000718 81.0
TLS2_k127_6786845_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K15408 - 1.9.3.1 1.415e-219 708.0
TLS2_k127_6786845_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003679 415.0
TLS2_k127_6786845_2 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005861 323.0
TLS2_k127_6786845_3 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K17223 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001279 280.0
TLS2_k127_6786845_4 Anabaena sensory rhodopsin transducer - - - 0.000000000000000000000000000000000000000000000001589 184.0
TLS2_k127_6786845_5 Cytochrome c - - - 0.000000000000000000000000000005357 126.0
TLS2_k127_6786845_6 pilus organization K12132 - 2.7.11.1 0.000000000000000008912 95.0
TLS2_k127_6786845_7 usher protein - - - 0.00000003985 67.0
TLS2_k127_6808263_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 6.082e-207 652.0
TLS2_k127_6808263_1 Protein of unknown function, DUF255 K06888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009154 497.0
TLS2_k127_6808263_10 translation initiation factor activity K06996 - - 0.0000000000000000001567 102.0
TLS2_k127_6808263_2 Sodium:neurotransmitter symporter family K03308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009349 459.0
TLS2_k127_6808263_3 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001593 274.0
TLS2_k127_6808263_4 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001321 255.0
TLS2_k127_6808263_5 PFAM Metal-dependent phosphohydrolase, HD K06951 - - 0.000000000000000000000000000000000000000000000000000000000005809 213.0
TLS2_k127_6808263_6 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000001883 165.0
TLS2_k127_6808263_7 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000004232 159.0
TLS2_k127_6808263_8 Zincin-like metallopeptidase - - - 0.000000000000000000001611 109.0
TLS2_k127_6808263_9 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.00000000000000000001795 102.0
TLS2_k127_6831906_0 Domain of unknown function (DUF5118) - - - 1.497e-208 676.0
TLS2_k127_6831906_1 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 469.0
TLS2_k127_6831906_2 M42 glutamyl aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005953 388.0
TLS2_k127_6831906_3 Metallopeptidase family M24 K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000001621 269.0
TLS2_k127_6831906_4 - - - - 0.000000000000000000000000000000000000000000000000000000000001978 218.0
TLS2_k127_6831906_5 ErfK ybiS ycfS ynhG family protein - - - 0.0000000000000000000000000000000000000000000000000000002852 211.0
TLS2_k127_6831906_6 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000008675 130.0
TLS2_k127_6831906_7 OsmC-like protein - - - 0.0000000000001532 76.0
TLS2_k127_6831906_8 NHL repeat - - - 0.0003775 52.0
TLS2_k127_6882743_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009972 621.0
TLS2_k127_6882743_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 385.0
TLS2_k127_6882743_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007403 289.0
TLS2_k127_6882743_3 Protein of unknown function, DUF547 - - - 0.000000000000000000000000000000000000000000000000004977 194.0
TLS2_k127_6882743_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000001817 161.0
TLS2_k127_6882743_5 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000009869 113.0
TLS2_k127_6882743_6 Domain of unknown function (DUF4126) - - - 0.0000000000000000002156 100.0
TLS2_k127_6888383_0 Dienelactone hydrolase family - - - 1.228e-233 747.0
TLS2_k127_6888383_1 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 625.0
TLS2_k127_6888383_10 Alpha beta hydrolase - - - 0.0000000000147 73.0
TLS2_k127_6888383_11 - - - - 0.000001551 60.0
TLS2_k127_6888383_2 PFAM OsmC family protein K06889,K07397 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 458.0
TLS2_k127_6888383_3 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009801 434.0
TLS2_k127_6888383_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 346.0
TLS2_k127_6888383_5 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001123 288.0
TLS2_k127_6888383_6 aminopeptidase K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000002991 273.0
TLS2_k127_6888383_7 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.0000000000000000000000000000000000000000000225 168.0
TLS2_k127_6888383_8 antibiotic catabolic process K18235 - - 0.000000000000000000000000000144 128.0
TLS2_k127_6888383_9 - - - - 0.00000000000007663 82.0
TLS2_k127_6926863_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835 - 5.4.2.2 5.827e-233 740.0
TLS2_k127_6926863_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 598.0
TLS2_k127_6926863_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001131 285.0
TLS2_k127_6926863_11 Fungal family of unknown function (DUF1776) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004914 273.0
TLS2_k127_6926863_12 HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001066 260.0
TLS2_k127_6926863_13 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000008964 230.0
TLS2_k127_6926863_14 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000001167 179.0
TLS2_k127_6926863_15 - - - - 0.00000000000000000000000000000000000000000002 177.0
TLS2_k127_6926863_16 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000229 138.0
TLS2_k127_6926863_17 HEAT repeats - - - 0.00000000000000000001302 102.0
TLS2_k127_6926863_18 glucose sorbosone - - - 0.000000000000000001366 93.0
TLS2_k127_6926863_19 - - - - 0.000000000000000001374 96.0
TLS2_k127_6926863_2 Carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007832 479.0
TLS2_k127_6926863_21 - - - - 0.0000000001089 66.0
TLS2_k127_6926863_22 - - - - 0.000001665 54.0
TLS2_k127_6926863_23 Beta-lactamase superfamily domain - - - 0.000002079 57.0
TLS2_k127_6926863_24 TonB-dependent Receptor Plug Domain K02014 - - 0.000004477 59.0
TLS2_k127_6926863_25 Acidic repeat-containing protein - GO:0000003,GO:0000280,GO:0000793,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0006139,GO:0006259,GO:0006304,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0022402,GO:0022414,GO:0034641,GO:0035510,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044728,GO:0045132,GO:0046483,GO:0048285,GO:0051321,GO:0070988,GO:0071704,GO:0071840,GO:0080111,GO:0090304,GO:0098813,GO:0140013,GO:1901360,GO:1903046 - 0.00000854 58.0
TLS2_k127_6926863_26 - - - - 0.00001321 56.0
TLS2_k127_6926863_27 AntiSigma factor - - - 0.00002906 54.0
TLS2_k127_6926863_28 AntiSigma factor - - - 0.00009644 55.0
TLS2_k127_6926863_29 Tetratricopeptide repeat - - - 0.0004386 52.0
TLS2_k127_6926863_3 Thiolase, C-terminal domain K00626,K07508 - 2.3.1.16,2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 448.0
TLS2_k127_6926863_4 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 427.0
TLS2_k127_6926863_5 Dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004142 370.0
TLS2_k127_6926863_6 Bacterial regulatory protein, Fis family K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 368.0
TLS2_k127_6926863_7 Phenazine biosynthesis-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 346.0
TLS2_k127_6926863_8 PFAM Band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 317.0
TLS2_k127_6926863_9 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 297.0
TLS2_k127_7008861_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 480.0
TLS2_k127_7008861_1 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 426.0
TLS2_k127_7008861_2 Peptidase family M1 domain K01256 - 3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004986 362.0
TLS2_k127_7008861_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 309.0
TLS2_k127_7008861_4 NUDIX hydrolase K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000000004547 197.0
TLS2_k127_7008861_5 ArsC family - - - 0.000000000000000000000000000000000000000000004854 169.0
TLS2_k127_7008861_6 - - - - 0.00000000000006723 81.0
TLS2_k127_7008861_7 Alpha/beta hydrolase family - - - 0.000000000006502 73.0
TLS2_k127_7042511_0 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 4.453e-241 766.0
TLS2_k127_7042511_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003096 437.0
TLS2_k127_7042511_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000898 383.0
TLS2_k127_7042511_3 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001496 275.0
TLS2_k127_7042511_4 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000003762 181.0
TLS2_k127_7042511_5 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000000198 173.0
TLS2_k127_7042511_6 Binds to the 23S rRNA K02939 - - 0.00000000000000000000000000000000000000293 153.0
TLS2_k127_7042511_7 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000000000001787 115.0
TLS2_k127_7042511_8 - - - - 0.0000000000000000000000003839 117.0
TLS2_k127_7042511_9 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000004411 105.0
TLS2_k127_7075521_0 radical SAM domain protein K04034 - 1.21.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009663 552.0
TLS2_k127_7075521_1 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 336.0
TLS2_k127_7075521_2 Hexosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001846 281.0
TLS2_k127_7075521_3 glycosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000001156 259.0
TLS2_k127_7075521_4 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000008185 225.0
TLS2_k127_7075521_5 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.000000000000000000000000000000000000007648 160.0
TLS2_k127_7075521_6 glycosyl transferase - - - 0.0000000000000000000000000000000000005598 160.0
TLS2_k127_7075521_7 O-Antigen ligase - - - 0.000000002487 68.0
TLS2_k127_7109593_0 ATP-dependent helicase HrpB K03579 - 3.6.4.13 2.191e-274 872.0
TLS2_k127_7109593_1 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 370.0
TLS2_k127_7109593_2 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002446 294.0
TLS2_k127_7109593_3 cAMP biosynthetic process K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000497 254.0
TLS2_k127_7109593_4 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000003814 183.0
TLS2_k127_7118179_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 9.586e-215 673.0
TLS2_k127_7118179_1 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 4.44e-207 652.0
TLS2_k127_7118179_10 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000000000000000000000001043 229.0
TLS2_k127_7118179_11 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000007675 220.0
TLS2_k127_7118179_12 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000004706 181.0
TLS2_k127_7118179_13 2-phosphosulpholactate phosphatase K05979 - 3.1.3.71 0.0000000000000000000000000000000000000000001946 168.0
TLS2_k127_7118179_14 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000008394 175.0
TLS2_k127_7118179_15 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000000000006632 159.0
TLS2_k127_7118179_16 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000000007287 149.0
TLS2_k127_7118179_17 methyltransferase - - - 0.000000000000000000000000000000000000601 156.0
TLS2_k127_7118179_18 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.000000000000000000000000002292 122.0
TLS2_k127_7118179_19 Glycosyl transferase family 2 - - - 0.0000000000000000000000000297 115.0
TLS2_k127_7118179_2 Ftsk_gamma K03466 - - 4.233e-202 658.0
TLS2_k127_7118179_20 50S ribosomal protein L31 K02909 - - 0.0000000000000000000000002728 108.0
TLS2_k127_7118179_21 Control of competence regulator ComK, YlbF/YmcA - - - 0.00000000000000000002609 100.0
TLS2_k127_7118179_23 membrane transporter protein - - - 0.000000000000000001907 96.0
TLS2_k127_7118179_24 Domain of unknown function (DUF4321) - - - 0.0000000001461 64.0
TLS2_k127_7118179_25 protein secretion K03116,K03117 - - 0.0000000001734 68.0
TLS2_k127_7118179_26 Tetratricopeptide repeat - - - 0.00000005678 66.0
TLS2_k127_7118179_3 Glutamate-1-semialdehyde aminotransferase K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 500.0
TLS2_k127_7118179_4 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 422.0
TLS2_k127_7118179_5 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000756 406.0
TLS2_k127_7118179_6 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 396.0
TLS2_k127_7118179_7 SurA N-terminal domain K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 331.0
TLS2_k127_7118179_8 Homoserine dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000299 269.0
TLS2_k127_7118179_9 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000002817 242.0
TLS2_k127_7208794_0 Involved in the tonB-independent uptake of proteins K03641 - - 3.528e-289 909.0
TLS2_k127_7208794_1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 297.0
TLS2_k127_7208794_10 Lipopolysaccharide-assembly - - - 0.000000000000000000000007347 108.0
TLS2_k127_7208794_11 - - - - 0.000000003305 68.0
TLS2_k127_7208794_14 - - - - 0.0000007107 62.0
TLS2_k127_7208794_15 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.00002705 47.0
TLS2_k127_7208794_2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008369 284.0
TLS2_k127_7208794_3 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003359 275.0
TLS2_k127_7208794_4 Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000004426 177.0
TLS2_k127_7208794_5 Calcineurin-like phosphoesterase K03269 - 3.6.1.54 0.0000000000000000000000000000000000000000000001194 177.0
TLS2_k127_7208794_6 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000002765 185.0
TLS2_k127_7208794_7 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000005747 166.0
TLS2_k127_7208794_8 Diacylglycerol kinase catalytic domain - - - 0.000000000000000000000000000000000000002587 159.0
TLS2_k127_7208794_9 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000001848 142.0
TLS2_k127_7225259_0 Methionine synthase B12-binding module cap domain protein K00548,K15023 - 2.1.1.13,2.1.1.258 0.0 1317.0
TLS2_k127_7225259_1 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 1.887e-254 802.0
TLS2_k127_7225259_10 aminopeptidase K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 361.0
TLS2_k127_7225259_11 Predicted permease YjgP/YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006406 316.0
TLS2_k127_7225259_12 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 298.0
TLS2_k127_7225259_13 Predicted permease YjgP/YjgQ family K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003786 263.0
TLS2_k127_7225259_14 metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003676 252.0
TLS2_k127_7225259_15 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000003716 232.0
TLS2_k127_7225259_16 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00000000000000000000000000000000000000000000000000000000001949 216.0
TLS2_k127_7225259_17 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 GO:0000166,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0036094,GO:0040007,GO:0042083,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050797,GO:0070402,GO:0097159,GO:1901265,GO:1901363 2.1.1.148 0.00000000000000000000000000000000000000000000000000000000003456 219.0
TLS2_k127_7225259_18 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000528 199.0
TLS2_k127_7225259_19 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000002917 186.0
TLS2_k127_7225259_2 N-Acyl-D-aspartate D-glutamate deacylase K01465,K06015 - 3.5.1.81,3.5.2.3 5.147e-228 723.0
TLS2_k127_7225259_20 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000007452 165.0
TLS2_k127_7225259_21 PFAM Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000001041 147.0
TLS2_k127_7225259_22 Bacterial Ig-like domain 2 - - - 0.000000000000000000000000000001024 141.0
TLS2_k127_7225259_23 efflux transmembrane transporter activity - - - 0.000000000000000000006015 109.0
TLS2_k127_7225259_24 domain, Protein - - - 0.00000000000000001055 98.0
TLS2_k127_7225259_25 NFU1 iron-sulfur cluster scaffold K22074 GO:0000166,GO:0003674,GO:0005198,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0017076,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0030554,GO:0031163,GO:0031974,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051186,GO:0051235,GO:0051238,GO:0051604,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0097428,GO:0097577,GO:0098771,GO:0106035,GO:1901265,GO:1901363,GO:1901564 - 0.00000000000003071 78.0
TLS2_k127_7225259_26 23S rRNA-intervening sequence protein - - - 0.0000000000004585 79.0
TLS2_k127_7225259_27 TIGRFAM competence protein ComEA helix-hairpin-helix repeat K02237 - - 0.00000000001586 74.0
TLS2_k127_7225259_28 Helix-hairpin-helix motif K02237 - - 0.00000004412 64.0
TLS2_k127_7225259_29 23S rRNA-intervening sequence protein - - - 0.0000006891 57.0
TLS2_k127_7225259_3 Type II secretion system (T2SS), protein E, N-terminal domain K02652 - - 1.115e-218 693.0
TLS2_k127_7225259_30 cAMP biosynthetic process - - - 0.0007066 46.0
TLS2_k127_7225259_31 Autotransporter beta-domain - - - 0.0009979 51.0
TLS2_k127_7225259_4 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 594.0
TLS2_k127_7225259_5 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 555.0
TLS2_k127_7225259_6 - - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0016278,GO:0016740,GO:0016741,GO:0032259 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 604.0
TLS2_k127_7225259_7 Type II secretion system (T2SS), protein F K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008973 522.0
TLS2_k127_7225259_8 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 476.0
TLS2_k127_7225259_9 amine dehydrogenase activity K20276 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 412.0
TLS2_k127_7229192_0 TonB-dependent Receptor Plug K02014 - - 2.225e-274 867.0
TLS2_k127_7229192_1 Membrane-bound dehydrogenase domain K09992 - - 1.474e-240 801.0
TLS2_k127_7229192_10 PFAM sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006043 465.0
TLS2_k127_7229192_11 antiporter K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 411.0
TLS2_k127_7229192_12 Phosphoenolpyruvate hydrolase-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 394.0
TLS2_k127_7229192_13 Bacterial transcriptional repressor C-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000001487 221.0
TLS2_k127_7229192_14 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000002246 192.0
TLS2_k127_7229192_15 extracellular polysaccharide biosynthetic process K13582 - - 0.00000000000000000000000000000000000000000000000002106 190.0
TLS2_k127_7229192_16 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000000001415 196.0
TLS2_k127_7229192_17 glyoxalase III activity - - - 0.0000000000000000000000000000005717 130.0
TLS2_k127_7229192_18 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000002425 109.0
TLS2_k127_7229192_19 Dodecin K09165 - - 0.000000000000000000006597 93.0
TLS2_k127_7229192_2 Na+/H+ antiporter family - - - 1.295e-213 670.0
TLS2_k127_7229192_20 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000001063 91.0
TLS2_k127_7229192_21 Transfers electrons from cytochrome c551 to cytochrome oxidase - GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009767,GO:0009987,GO:0015979,GO:0016020,GO:0019684,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046872,GO:0046914,GO:0055114,GO:0071944 - 0.000000000000005063 81.0
TLS2_k127_7229192_23 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.00000000000002319 81.0
TLS2_k127_7229192_24 lipolytic protein G-D-S-L family - - - 0.000000000000224 83.0
TLS2_k127_7229192_3 domain, Protein - - - 1.987e-207 666.0
TLS2_k127_7229192_4 Sodium:solute symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 609.0
TLS2_k127_7229192_5 COG1115 Na alanine symporter K03310 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006959 548.0
TLS2_k127_7229192_6 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 547.0
TLS2_k127_7229192_7 Uncharacterised protein family (UPF0261) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009787 502.0
TLS2_k127_7229192_8 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008407 496.0
TLS2_k127_722932_0 Insulinase (Peptidase family M16) K07263 - - 1.767e-277 883.0
TLS2_k127_722932_1 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 427.0
TLS2_k127_722932_2 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001364 280.0
TLS2_k127_722932_3 response regulator - - - 0.0000000000000000000000000000000000000000000000000000004539 198.0
TLS2_k127_722932_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000002801 107.0
TLS2_k127_722932_5 Putative lumazine-binding - - - 0.00000000000001169 80.0
TLS2_k127_727372_0 amine dehydrogenase activity K17285 - - 4.098e-227 712.0
TLS2_k127_727372_1 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 574.0
TLS2_k127_727372_10 - - - - 0.000000000000000000000000000000000000000000000000000007973 202.0
TLS2_k127_727372_11 Protein of unknown function, DUF - - - 0.00000000000000000000000000000000000000546 150.0
TLS2_k127_727372_12 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000005569 128.0
TLS2_k127_727372_13 capsular polysaccharide biosynthesis protein K01104 - 3.1.3.48 0.0000000000000000000000000002888 124.0
TLS2_k127_727372_14 long-chain fatty acid transport protein - - - 0.0000000000000000000000003176 117.0
TLS2_k127_727372_15 transcriptional regulators - - - 0.00000000000000000005144 93.0
TLS2_k127_727372_16 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000198 57.0
TLS2_k127_727372_2 MatE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 515.0
TLS2_k127_727372_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 525.0
TLS2_k127_727372_4 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003644 518.0
TLS2_k127_727372_5 B3 4 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006761 294.0
TLS2_k127_727372_6 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000001017 255.0
TLS2_k127_727372_7 serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000006378 241.0
TLS2_k127_727372_8 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000001078 209.0
TLS2_k127_727372_9 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000001032 208.0
TLS2_k127_7319437_0 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 530.0
TLS2_k127_7319437_1 GDP-mannose 4,6 dehydratase K17947 - 5.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 513.0
TLS2_k127_7319437_10 Protein of unknown function (DUF1698) K15257 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 323.0
TLS2_k127_7319437_11 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003624 312.0
TLS2_k127_7319437_12 Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001111 282.0
TLS2_k127_7319437_13 Serine threonine protein kinase involved in cell cycle control - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001822 265.0
TLS2_k127_7319437_14 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000852 237.0
TLS2_k127_7319437_15 Alpha-amylase domain K01182,K01187,K01226 - 3.2.1.10,3.2.1.20,3.2.1.93 0.0000000000000000000000000000000000000000000000000000000000000851 219.0
TLS2_k127_7319437_16 COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase) - - - 0.000000000000000000000000000000000000000000000000003828 194.0
TLS2_k127_7319437_17 Domain of unknown function (DUF892) - - - 0.000000000000000000000000000000000000000000000431 174.0
TLS2_k127_7319437_18 Metal-sensitive transcriptional repressor K21600 - - 0.000000000000000000000000000000000000002474 151.0
TLS2_k127_7319437_19 - - - - 0.00000000000000000000000000000000000008732 155.0
TLS2_k127_7319437_2 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 491.0
TLS2_k127_7319437_20 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000008583 124.0
TLS2_k127_7319437_21 Protein of unknown function (DUF3037) - - - 0.000000000000000001224 94.0
TLS2_k127_7319437_22 Cupin 2, conserved barrel domain protein - - - 0.0000000988 61.0
TLS2_k127_7319437_24 protein histidine kinase activity - - - 0.00006017 53.0
TLS2_k127_7319437_3 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 490.0
TLS2_k127_7319437_4 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 445.0
TLS2_k127_7319437_5 Male sterility protein K12454 - 5.1.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 436.0
TLS2_k127_7319437_6 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 404.0
TLS2_k127_7319437_7 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 363.0
TLS2_k127_7319437_8 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008942 365.0
TLS2_k127_7319437_9 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 361.0
TLS2_k127_7320307_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 1.261e-258 805.0
TLS2_k127_7320307_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 5.278e-243 778.0
TLS2_k127_7320307_10 Receptor family ligand-binding protein K01999 - - 0.0000000000007158 80.0
TLS2_k127_7320307_11 histidine kinase A domain protein K07647,K07678 - 2.7.13.3 0.000000009092 63.0
TLS2_k127_7320307_2 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006801 513.0
TLS2_k127_7320307_3 3-phosphoshikimate 1-carboxyvinyltransferase activity K00800 GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008279 392.0
TLS2_k127_7320307_4 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 368.0
TLS2_k127_7320307_5 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800,K00945 - 2.5.1.19,2.7.4.25 0.0000000000000000000000000000000000000000000000000003303 196.0
TLS2_k127_7320307_6 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000005584 162.0
TLS2_k127_7320307_7 phosphorelay signal transduction system - - - 0.000000000000000000000000000002769 124.0
TLS2_k127_7320307_8 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000003445 115.0
TLS2_k127_7320307_9 PFAM GGDEF domain containing protein - - - 0.0000000000000000001006 104.0
TLS2_k127_7413787_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 3.507e-315 976.0
TLS2_k127_7413787_1 glutamine synthetase K01915 - 6.3.1.2 1.115e-312 974.0
TLS2_k127_7413787_10 Electron transfer flavoprotein domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 316.0
TLS2_k127_7413787_11 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 303.0
TLS2_k127_7413787_12 O-acyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 296.0
TLS2_k127_7413787_13 COG0714 MoxR-like ATPases K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 298.0
TLS2_k127_7413787_14 domain, Protein K01179,K07260,K13735 - 3.2.1.4,3.4.17.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004589 291.0
TLS2_k127_7413787_15 Domain of unknown function (DUF3488) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001431 285.0
TLS2_k127_7413787_16 Belongs to the GHMP kinase family K00849 - 2.7.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000003662 274.0
TLS2_k127_7413787_17 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000008557 278.0
TLS2_k127_7413787_18 Electron transfer flavoprotein domain K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000006883 238.0
TLS2_k127_7413787_19 Binding-protein-dependent transport system inner membrane component K05773 - - 0.000000000000000000000000000000000000000000000000000000000001083 217.0
TLS2_k127_7413787_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 1.349e-223 709.0
TLS2_k127_7413787_20 extracellular solute-binding protein, family 1 K05772 - - 0.0000000000000000000000000000000000000000000000000000000000203 217.0
TLS2_k127_7413787_21 GGDEF domain K11527 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000005983 222.0
TLS2_k127_7413787_22 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000002691 216.0
TLS2_k127_7413787_23 TOBE domain K02052 - - 0.000000000000000000000000000000000000000000000000001284 199.0
TLS2_k127_7413787_24 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.00000000000000000000000000000000000000000000000003379 186.0
TLS2_k127_7413787_25 spore germination - - - 0.00000000000000000000000000000000000000000000002506 187.0
TLS2_k127_7413787_26 Conserved TM helix - - - 0.00000000000000000000000000000000000000000000278 175.0
TLS2_k127_7413787_27 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.63 0.000000000000000000000000000000000000000003529 165.0
TLS2_k127_7413787_28 ANTAR - - - 0.0000000000000000000000000000000000000004294 161.0
TLS2_k127_7413787_29 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000006092 153.0
TLS2_k127_7413787_3 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor K00311 GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 9.078e-215 679.0
TLS2_k127_7413787_30 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000001592 156.0
TLS2_k127_7413787_31 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000000000000000000000000000000000002177 153.0
TLS2_k127_7413787_32 - - - - 0.000000000000000000000000000000000005731 147.0
TLS2_k127_7413787_33 Ferric uptake regulator family K09825 - - 0.000000000000000000000000000000000014 141.0
TLS2_k127_7413787_34 PFAM Lytic transglycosylase catalytic K08307 - - 0.0000000000000000000000000006304 121.0
TLS2_k127_7413787_35 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000000009699 113.0
TLS2_k127_7413787_36 FdhD/NarQ family K02379 - - 0.000000000000000000005236 102.0
TLS2_k127_7413787_37 Protein of unknown function (DUF1232) - - - 0.00000000000000000001361 96.0
TLS2_k127_7413787_38 - - - - 0.0000000000000001362 84.0
TLS2_k127_7413787_39 RESPONSE REGULATOR receiver - - - 0.000000000008325 70.0
TLS2_k127_7413787_4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 8.876e-214 674.0
TLS2_k127_7413787_40 - - - - 0.00000002115 68.0
TLS2_k127_7413787_41 OST-HTH/LOTUS domain - - - 0.0000003527 63.0
TLS2_k127_7413787_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 612.0
TLS2_k127_7413787_6 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007942 584.0
TLS2_k127_7413787_7 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 451.0
TLS2_k127_7413787_8 AlkA N-terminal domain K13529 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 432.0
TLS2_k127_7413787_9 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 357.0
TLS2_k127_7450115_0 Penicillin amidase K07116 - 3.5.1.97 8.253e-288 903.0
TLS2_k127_7450115_1 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002845 538.0
TLS2_k127_7450115_2 Lanthionine synthetase C-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004131 476.0
TLS2_k127_7450115_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000002943 229.0
TLS2_k127_7450115_4 nuclear chromosome segregation - - - 0.00000001495 69.0
TLS2_k127_7450115_5 COG0666 FOG Ankyrin repeat - - - 0.000001445 51.0
TLS2_k127_893646_0 LVIVD repeat - - - 2.445e-285 895.0
TLS2_k127_893646_1 PQQ-like domain K00117 - 1.1.5.2 1.077e-227 725.0
TLS2_k127_893646_10 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 448.0
TLS2_k127_893646_11 Protein of unknown function (DUF819) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 437.0
TLS2_k127_893646_12 TIGRFAM amidase, hydantoinase carbamoylase family K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 435.0
TLS2_k127_893646_13 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004554 432.0
TLS2_k127_893646_14 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 426.0
TLS2_k127_893646_15 DNA restriction-modification system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004073 435.0
TLS2_k127_893646_16 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 429.0
TLS2_k127_893646_17 TonB-dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008754 420.0
TLS2_k127_893646_18 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 396.0
TLS2_k127_893646_19 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 403.0
TLS2_k127_893646_2 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 6.255e-220 706.0
TLS2_k127_893646_20 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004412 372.0
TLS2_k127_893646_21 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 337.0
TLS2_k127_893646_22 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006408 331.0
TLS2_k127_893646_23 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009773 311.0
TLS2_k127_893646_24 Glutamine cyclotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001086 273.0
TLS2_k127_893646_25 PFAM ATP-binding region, ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000056 252.0
TLS2_k127_893646_26 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000004135 235.0
TLS2_k127_893646_27 PFAM helicase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000002032 234.0
TLS2_k127_893646_28 Domain of unknown function (DUF305) - - - 0.00000000000000000000000000000000000000000000000000000000003733 218.0
TLS2_k127_893646_29 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000000000000000000000224 218.0
TLS2_k127_893646_3 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 8.457e-210 667.0
TLS2_k127_893646_30 - - - - 0.00000000000000000000000000000000000000000000000000001665 205.0
TLS2_k127_893646_31 Ferric uptake regulator family K03711 - - 0.0000000000000000000000000000000000000000000000002794 186.0
TLS2_k127_893646_32 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000001803 174.0
TLS2_k127_893646_33 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000001785 160.0
TLS2_k127_893646_34 protein conserved in bacteria K09922 - - 0.00000000000000000000000000000000000001498 150.0
TLS2_k127_893646_35 peroxiredoxin activity - - - 0.0000000000000000000000000003996 123.0
TLS2_k127_893646_36 Cytochrome c - - - 0.00000000000000000000003226 105.0
TLS2_k127_893646_37 Transcriptional regulator PadR-like family - - - 0.000000000000001189 81.0
TLS2_k127_893646_38 Transcriptional regulator PadR-like family - - - 0.000002263 59.0
TLS2_k127_893646_39 NHL repeat - - - 0.00001471 57.0
TLS2_k127_893646_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.368e-209 666.0
TLS2_k127_893646_40 DinB family - - - 0.00009831 53.0
TLS2_k127_893646_42 MerC mercury resistance protein - - - 0.0008015 48.0
TLS2_k127_893646_5 domain, Protein - - - 2.513e-208 669.0
TLS2_k127_893646_6 von Willebrand factor type A domain K07114 - - 6.242e-198 639.0
TLS2_k127_893646_7 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 593.0
TLS2_k127_893646_8 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008577 519.0
TLS2_k127_893646_9 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008497 534.0
TLS2_k127_918591_0 transmembrane transporter activity K03296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 436.0
TLS2_k127_918591_1 PFAM metal-dependent phosphohydrolase HD sub domain K09163 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 299.0
TLS2_k127_918591_2 PFAM Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000001377 213.0
TLS2_k127_918591_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000002967 181.0
TLS2_k127_918591_4 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000002169 169.0
TLS2_k127_918591_5 NHL repeat - - - 0.000001958 60.0
TLS2_k127_918591_6 Outer membrane efflux protein K12340 - - 0.00008546 55.0
TLS2_k127_918591_7 PFAM NHL repeat containing protein - - - 0.0005545 52.0
TLS2_k127_937972_0 C-terminal, D2-small domain, of ClpB protein K11907 - - 0.0 1021.0
TLS2_k127_937972_1 RHS Repeat - - - 1.725e-221 738.0
TLS2_k127_937972_2 Phage late control gene D protein (GPD) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 517.0
TLS2_k127_951972_0 Phage tail sheath protein K06907 - - 5.123e-197 633.0
TLS2_k127_951972_1 heme-copper terminal oxidase activity K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 621.0
TLS2_k127_951972_2 T4-like virus tail tube protein gp19 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007197 321.0
TLS2_k127_951972_3 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009229 271.0
TLS2_k127_951972_4 cytochrome c oxidase (Subunit II) - - - 0.0000000000000000000000000000000000000000000000000000000001504 211.0
TLS2_k127_951972_5 - - - - 0.0000000000000000000000000000000000000005972 164.0
TLS2_k127_951972_6 Tetratricopeptide repeat - - - 0.000000000000000001606 99.0
TLS2_k127_951972_7 Tetratricopeptide repeat - - - 0.000000000000004511 88.0
TLS2_k127_951972_8 Electron transport protein SCO1 SenC K07152 - - 0.000000000008266 79.0
TLS2_k127_951972_9 - - - - 0.0002798 45.0
TLS2_k127_969417_0 Bacterial protein of unknown function (DUF885) - - - 1.678e-207 661.0
TLS2_k127_969417_1 TIGRFAM Aspartate kinase K12524 - 1.1.1.3,2.7.2.4 6.542e-205 665.0
TLS2_k127_969417_10 Carboxypeptidase regulatory-like domain K02014 - - 0.000000000000004419 87.0
TLS2_k127_969417_2 ATP ADP translocase K03301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 604.0
TLS2_k127_969417_3 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004811 359.0
TLS2_k127_969417_4 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000122 215.0
TLS2_k127_969417_5 Domain of unknown function (DUF4105) - - - 0.0000000000000000000000000000000000000000000000000000000266 210.0
TLS2_k127_969417_6 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000008125 199.0
TLS2_k127_969417_7 peroxidase activity K09162 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 0.0000000000000000000000000000000000000000000002002 179.0
TLS2_k127_969417_8 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000001145 173.0
TLS2_k127_969417_9 domain, Protein - - - 0.000000000000000000000003333 120.0
TLS2_k127_97327_0 COG1233 Phytoene dehydrogenase and related - - - 3.703e-243 774.0
TLS2_k127_97327_1 Flavin containing amine oxidoreductase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 7.297e-215 683.0
TLS2_k127_97327_10 NUDIX domain K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000002958 201.0
TLS2_k127_97327_11 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000003743 205.0
TLS2_k127_97327_12 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K01647,K22491 - 2.3.3.1 0.00000000000000000000000000000000000000000000000001002 193.0
TLS2_k127_97327_13 Thiol-disulfide oxidoreductase - - - 0.000000000000000000000000000000000000000000003117 168.0
TLS2_k127_97327_14 RF-1 domain K15034 - - 0.00000000000000000000000000004797 128.0
TLS2_k127_97327_15 Acyl-transferase K00655 - 2.3.1.51 0.0000000000000000000000000002005 129.0
TLS2_k127_97327_16 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0000000000000000000003314 104.0
TLS2_k127_97327_18 isoprenoid biosynthetic process K00805,K02523 - 2.5.1.30,2.5.1.90 0.0000000000000001559 94.0
TLS2_k127_97327_19 CHAT domain - - - 0.0000000000000004902 93.0
TLS2_k127_97327_2 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 623.0
TLS2_k127_97327_3 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 594.0
TLS2_k127_97327_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 313.0
TLS2_k127_97327_5 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009697 295.0
TLS2_k127_97327_6 Carotenoid biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001058 278.0
TLS2_k127_97327_7 Membrane K22502 - 5.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000001518 247.0
TLS2_k127_97327_8 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000001019 246.0
TLS2_k127_97327_9 dehydratase - - - 0.000000000000000000000000000000000000000000000000000000002637 206.0
TLS2_k127_974357_0 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 4.195e-289 914.0
TLS2_k127_974357_1 Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 600.0
TLS2_k127_974357_10 Histidine kinase - - - 0.00000000000000000000000000000000000000004095 169.0
TLS2_k127_974357_11 ECF sigma factor - - - 0.00000000000000000000000000000000000000004166 166.0
TLS2_k127_974357_12 - - - - 0.00000000000000000000000053 119.0
TLS2_k127_974357_13 Tellurite resistance protein TerB - - - 0.0000000000000000000000434 112.0
TLS2_k127_974357_15 - - - - 0.00000000004218 69.0
TLS2_k127_974357_16 peptidyl-tyrosine sulfation - - - 0.00000000008666 76.0
TLS2_k127_974357_18 superoxide dismutase activity K02674,K04565 - 1.15.1.1 0.00001841 53.0
TLS2_k127_974357_19 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00004623 53.0
TLS2_k127_974357_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003836 403.0
TLS2_k127_974357_3 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 349.0
TLS2_k127_974357_4 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003073 251.0
TLS2_k127_974357_5 - - - - 0.00000000000000000000000000000000000000000000000000000001924 204.0
TLS2_k127_974357_6 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000009073 194.0
TLS2_k127_974357_7 Cupin domain - - - 0.00000000000000000000000000000000000000000000002109 173.0
TLS2_k127_974357_8 Thioredoxin-like domain K03672 - 1.8.1.8 0.0000000000000000000000000000000000000000000001245 178.0
TLS2_k127_974357_9 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000009389 165.0