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Overview

ID MAG04012
Name TLS2_bin.52
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Methylomirabilota
Class Methylomirabilia
Order Rokubacteriales
Family CSP1-6
Genus
Species
Assembly information
Completeness (%) 75.62
Contamination (%) 4.95
GC content (%) 72.0
N50 (bp) 18,774
Genome size (bp) 4,095,712

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3728

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1006178_0 PFAM D-galactarate dehydratase Altronate hydrolase K01685 - 4.2.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 578.0
TLS2_k127_1006178_1 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 491.0
TLS2_k127_1006178_2 L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006772 460.0
TLS2_k127_1006178_3 cation diffusion facilitator family transporter K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 300.0
TLS2_k127_1006178_4 acyl-CoA dehydrogenase activity K00248,K00253 - 1.3.8.1,1.3.8.4 0.00000000000000000000000000000000000000000000000000000001162 217.0
TLS2_k127_1006178_5 PFAM MaoC domain protein dehydratase K14449 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0015977,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043427,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046487,GO:0071704,GO:0072329,GO:1901575 4.2.1.148 0.000000000000000000000000000000000000000000002394 177.0
TLS2_k127_1006178_6 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000002519 168.0
TLS2_k127_1006178_7 acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.00000000000000000000000000000001878 143.0
TLS2_k127_1006178_8 - - - - 0.000000000000000000000005165 116.0
TLS2_k127_1006178_9 ATP-dependent Clp protease adaptor protein ClpS - - - 0.00000000000001242 79.0
TLS2_k127_1023078_0 AAA ATPase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007999 635.0
TLS2_k127_1023078_1 AAA domain - - - 0.000000000000000000000000000000000000131 146.0
TLS2_k127_1023078_2 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000006938 106.0
TLS2_k127_1023078_3 Major Facilitator Superfamily - - - 0.0000000000000001246 85.0
TLS2_k127_1023078_4 transposase IS116 IS110 IS902 family protein - - - 0.00000000000000669 78.0
TLS2_k127_1023078_5 AAA domain - - - 0.0000000002066 65.0
TLS2_k127_1023078_6 DNA integration - - - 0.00000002999 59.0
TLS2_k127_1023078_7 Methylmuconolactone methyl-isomerase - - - 0.000004442 53.0
TLS2_k127_1023078_8 Major Facilitator Superfamily - - - 0.00007976 50.0
TLS2_k127_1049178_0 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 616.0
TLS2_k127_1049178_1 PFAM Hydantoinase B oxoprolinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 575.0
TLS2_k127_1049178_10 methylmalonyl-CoA mutase C-terminal K01849 - 5.4.99.2 0.00000000000000000000000000000000000000003559 166.0
TLS2_k127_1049178_11 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000003028 128.0
TLS2_k127_1049178_12 GntR family transcriptional regulator K03486,K03710 - - 0.000000000000000000000000102 116.0
TLS2_k127_1049178_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 560.0
TLS2_k127_1049178_3 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 485.0
TLS2_k127_1049178_4 Acyl-CoA dehydrogenase, N-terminal domain K18244 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 397.0
TLS2_k127_1049178_5 COG1960 Acyl-CoA dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000633 362.0
TLS2_k127_1049178_6 3-hydroxyacyl-CoA dehydrogenase domain protein K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007544 355.0
TLS2_k127_1049178_7 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000001819 215.0
TLS2_k127_1049178_8 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01563 - 3.8.1.5 0.0000000000000000000000000000000000000000000000000000631 200.0
TLS2_k127_1049178_9 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000000000000002395 196.0
TLS2_k127_1144222_0 Threonine synthase K01733 - 4.2.3.1 1.266e-196 620.0
TLS2_k127_1144222_1 DegT/DnrJ/EryC1/StrS aminotransferase family K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009369 478.0
TLS2_k127_1144222_10 glycerophosphoryl diester phosphodiesterase K01113,K01126 - 3.1.3.1,3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000002342 251.0
TLS2_k127_1144222_11 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000001771 193.0
TLS2_k127_1144222_12 ThiS family K03636,K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000001415 119.0
TLS2_k127_1144222_13 methionine transport K02071 - - 0.0000000000000004051 81.0
TLS2_k127_1144222_14 Haem-degrading - - - 0.0000000002168 68.0
TLS2_k127_1144222_2 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007083 381.0
TLS2_k127_1144222_3 PFAM PfkB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004512 366.0
TLS2_k127_1144222_4 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 378.0
TLS2_k127_1144222_5 MiaB-like tRNA modifying enzyme K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 351.0
TLS2_k127_1144222_6 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009626 335.0
TLS2_k127_1144222_7 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 337.0
TLS2_k127_1144222_8 tRNA processing K06864,K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 317.0
TLS2_k127_1144222_9 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001618 278.0
TLS2_k127_1152846_0 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 374.0
TLS2_k127_1152846_1 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005485 348.0
TLS2_k127_1152846_2 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 321.0
TLS2_k127_1152846_3 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 295.0
TLS2_k127_1152846_4 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005037 256.0
TLS2_k127_1152846_5 Psort location Cytoplasmic, score K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000315 167.0
TLS2_k127_1152846_6 KR domain - - - 0.000000000000000000000000000000000000002687 169.0
TLS2_k127_1152846_7 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000001316 129.0
TLS2_k127_1152846_8 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.0005378 48.0
TLS2_k127_1153225_0 Peptidase dimerisation domain K21613 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 326.0
TLS2_k127_1153225_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006065 306.0
TLS2_k127_1153225_2 amidohydrolase K21613 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003304 314.0
TLS2_k127_1153225_3 metal-dependent enzyme of the double-stranded beta helix superfamily - - - 0.00000000000000000000000000000000000000000000000000000000001455 220.0
TLS2_k127_1153225_4 PAS fold - - - 0.0000000000000000000000000003425 119.0
TLS2_k127_1211390_0 FAD dependent oxidoreductase central domain - - - 0.0 1346.0
TLS2_k127_1211390_1 AMP-binding enzyme C-terminal domain K00666 - - 4.393e-234 737.0
TLS2_k127_1211390_10 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003187 299.0
TLS2_k127_1211390_11 PFAM Dimethylmenaquinone methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001762 247.0
TLS2_k127_1211390_12 PFAM Glyoxalase bleomycin resistance protein dioxygenase K11945 - - 0.000000000000000000000000000000000000000000000000000000000000000111 232.0
TLS2_k127_1211390_13 transport system periplasmic component K01989 - - 0.00000000000000000000000000000000000000000008138 173.0
TLS2_k127_1211390_14 NlpC p60 family K13694,K21471 - 3.4.17.13 0.0000000000000000000000000000003485 136.0
TLS2_k127_1211390_15 Thioredoxin-like - - - 0.000000000000000000000000002096 118.0
TLS2_k127_1211390_17 SnoaL-like domain - - - 0.00000000002218 69.0
TLS2_k127_1211390_2 Sodium/hydrogen exchanger family - - - 1.931e-219 702.0
TLS2_k127_1211390_20 peroxiredoxin activity K03564 - 1.11.1.15 0.000000006133 63.0
TLS2_k127_1211390_21 Redoxin K03564 - 1.11.1.15 0.000001215 54.0
TLS2_k127_1211390_3 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 484.0
TLS2_k127_1211390_4 Histidinol-phosphate aromatic aminotransferase and cobyric acid decarboxylase K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 473.0
TLS2_k127_1211390_5 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 407.0
TLS2_k127_1211390_6 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 415.0
TLS2_k127_1211390_7 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 387.0
TLS2_k127_1211390_8 Alkyl sulfatase dimerisation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000435 355.0
TLS2_k127_1211390_9 Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006774 374.0
TLS2_k127_1226039_0 Transketolase, pyrimidine binding domain K11381,K21416 - 1.2.4.4 1.646e-235 749.0
TLS2_k127_1226039_1 Copper amine oxidase, enzyme domain K00276 - 1.4.3.21 6.455e-216 680.0
TLS2_k127_1226039_10 COG0694 Thioredoxin-like proteins and domains - - - 0.0000000000000000000000000008521 121.0
TLS2_k127_1226039_11 PFAM Iron sulphur-containing domain, CDGSH-type - - - 0.000000000000000005593 98.0
TLS2_k127_1226039_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 488.0
TLS2_k127_1226039_3 ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003657 433.0
TLS2_k127_1226039_4 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 402.0
TLS2_k127_1226039_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007053 339.0
TLS2_k127_1226039_6 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 322.0
TLS2_k127_1226039_7 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000001378 258.0
TLS2_k127_1226039_8 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000005359 247.0
TLS2_k127_1226039_9 Belongs to the peptidase S51 family K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.0000000000000000000000000000000000000000000000001647 186.0
TLS2_k127_1234539_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 3.314e-230 736.0
TLS2_k127_1234539_1 PFAM AMP-dependent synthetase and ligase K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 608.0
TLS2_k127_1234539_10 Amidohydrolase family K01464 - 3.5.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 327.0
TLS2_k127_1234539_11 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 319.0
TLS2_k127_1234539_12 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 302.0
TLS2_k127_1234539_13 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431 - 3.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 291.0
TLS2_k127_1234539_14 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001335 252.0
TLS2_k127_1234539_15 Amino acid synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000136 227.0
TLS2_k127_1234539_16 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.00000000000000000000000000000000000000000000000000000001259 209.0
TLS2_k127_1234539_17 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000006466 205.0
TLS2_k127_1234539_18 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0000000000000000000000000000000000000000000000000002929 188.0
TLS2_k127_1234539_19 transcriptional regulator (RpiR family) - - - 0.00000000000000000000000000000000000000000000002033 182.0
TLS2_k127_1234539_2 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 473.0
TLS2_k127_1234539_20 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000001873 139.0
TLS2_k127_1234539_21 ATP-independent chaperone mediated protein folding - - - 0.000000000000000000000005111 110.0
TLS2_k127_1234539_22 Universal stress protein family - - - 0.0000000000000000001556 98.0
TLS2_k127_1234539_23 - - - - 0.00000000000002852 78.0
TLS2_k127_1234539_24 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000006959 82.0
TLS2_k127_1234539_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007017 466.0
TLS2_k127_1234539_4 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 421.0
TLS2_k127_1234539_5 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 439.0
TLS2_k127_1234539_6 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 409.0
TLS2_k127_1234539_7 proline dipeptidase activity K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004443 402.0
TLS2_k127_1234539_8 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 339.0
TLS2_k127_1234539_9 response regulator K02483,K07661,K18073 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003983 327.0
TLS2_k127_1257184_0 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00800,K04116,K12507 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009413 514.0
TLS2_k127_1257184_1 Acyl-CoA dehydrogenase, N-terminal domain K04117 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 429.0
TLS2_k127_1257184_2 KR domain K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004772 348.0
TLS2_k127_1257184_3 Enoyl-(Acyl carrier protein) reductase K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000002519 214.0
TLS2_k127_1257184_4 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000007524 201.0
TLS2_k127_1257184_5 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 - 4.1.3.36 0.000000000000000000000000000000000000000000002578 166.0
TLS2_k127_125973_0 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 2.522e-306 951.0
TLS2_k127_125973_1 Hydantoinase/oxoprolinase - - - 6.177e-268 840.0
TLS2_k127_125973_10 extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000002911 133.0
TLS2_k127_125973_11 Alpha beta hydrolase - - - 0.000000000000000000000000000006617 131.0
TLS2_k127_125973_12 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000006733 75.0
TLS2_k127_125973_13 Glutaredoxin - - - 0.000000000003587 68.0
TLS2_k127_125973_14 Carboxymuconolactone decarboxylase family - - - 0.000004031 55.0
TLS2_k127_125973_2 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 554.0
TLS2_k127_125973_3 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009033 466.0
TLS2_k127_125973_4 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006323 326.0
TLS2_k127_125973_5 PFAM Ribonuclease BN-like family K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005112 301.0
TLS2_k127_125973_6 carboxymuconolactone decarboxylase - - - 0.00000000000000000000000000000000000000000000000004991 190.0
TLS2_k127_125973_7 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000004733 197.0
TLS2_k127_125973_8 photosynthesis - - - 0.000000000000000000000000000000000000000000000009217 187.0
TLS2_k127_125973_9 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000005672 142.0
TLS2_k127_1273284_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 5.124e-204 651.0
TLS2_k127_1273284_1 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 608.0
TLS2_k127_1273284_10 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0005206 47.0
TLS2_k127_1273284_2 Endoribonuclease that initiates mRNA decay K18682 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007523 522.0
TLS2_k127_1273284_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 410.0
TLS2_k127_1273284_4 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 368.0
TLS2_k127_1273284_5 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007697 326.0
TLS2_k127_1273284_6 PFAM Metallophosphoesterase K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 308.0
TLS2_k127_1273284_7 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.00000000000000000000000000000000000000000000000000007169 195.0
TLS2_k127_1273284_8 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000009555 133.0
TLS2_k127_1273284_9 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000002434 72.0
TLS2_k127_1276251_0 ABC-type multidrug transport system ATPase and permease K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 602.0
TLS2_k127_1276251_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 350.0
TLS2_k127_1276251_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000368 320.0
TLS2_k127_1276251_3 polysaccharide catabolic process K03478 - 3.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000005305 247.0
TLS2_k127_1276251_4 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000003952 166.0
TLS2_k127_1276251_5 PFAM Transposase IS116 IS110 IS902 family, Transposase - - - 0.0000000000000000004968 100.0
TLS2_k127_1276251_6 Amidohydrolase family K01464 - 3.5.2.2 0.000000000000006243 87.0
TLS2_k127_1276251_7 - - - - 0.000000000000006708 79.0
TLS2_k127_1276251_8 Nodulation protein S (NodS) - - - 0.0000000000001217 83.0
TLS2_k127_1276251_9 PFAM Glycosyl transferase family 2 - - - 0.00000000009278 73.0
TLS2_k127_1276391_0 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007178 564.0
TLS2_k127_1276391_1 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 408.0
TLS2_k127_1276391_2 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 315.0
TLS2_k127_1276391_3 Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine K18911 - 2.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001963 290.0
TLS2_k127_1276391_4 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009138 285.0
TLS2_k127_1276391_5 abc transporter atp-binding protein K05847 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004419 262.0
TLS2_k127_1276391_6 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000008661 243.0
TLS2_k127_1276391_7 ATPases associated with a variety of cellular activities K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000003829 245.0
TLS2_k127_1276391_8 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000001196 223.0
TLS2_k127_1276391_9 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000006432 85.0
TLS2_k127_1283254_0 dipeptide transport K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 338.0
TLS2_k127_1283254_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008263 309.0
TLS2_k127_1283254_2 Nitroreductase family - - - 0.0000000000000000001872 88.0
TLS2_k127_1283254_3 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033,K15581 - - 0.00000001644 55.0
TLS2_k127_1289253_0 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 596.0
TLS2_k127_1289253_1 Amidase K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 490.0
TLS2_k127_1289253_10 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.00000000000000000000000003903 115.0
TLS2_k127_1289253_11 response regulator K02481,K07715 - - 0.000000000000000000008822 97.0
TLS2_k127_1289253_12 PFAM RNP-1 like RNA-binding protein - - - 0.0000000000001512 77.0
TLS2_k127_1289253_13 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.0000000001001 72.0
TLS2_k127_1289253_2 Putative zinc-binding metallo-peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 417.0
TLS2_k127_1289253_3 ATP-grasp domain K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 306.0
TLS2_k127_1289253_4 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000096 275.0
TLS2_k127_1289253_5 Ketopantoate reductase PanE/ApbA C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006505 272.0
TLS2_k127_1289253_6 hydrolase (HAD superfamily) K01560,K07025,K08723 - 3.1.3.5,3.8.1.2 0.00000000000000000000000000000000000000000000000000002909 196.0
TLS2_k127_1289253_7 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000001553 189.0
TLS2_k127_1289253_8 Removes 5-oxoproline from various penultimate amino acid residues except L-proline K01304 GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564 3.4.19.3 0.00000000000000000000000000000000000000000003097 168.0
TLS2_k127_1289253_9 Domain of Unknown Function (DUF748) - - - 0.000000000000000000000000000001601 142.0
TLS2_k127_13090_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 1.308e-247 801.0
TLS2_k127_13090_1 Transport permease protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 413.0
TLS2_k127_13090_10 PRC-barrel domain - - - 0.0000002903 60.0
TLS2_k127_13090_11 periplasmic or secreted lipoprotein - - - 0.00009244 52.0
TLS2_k127_13090_12 Class ii aldolase K01628,K03077 - 4.1.2.17,5.1.3.4 0.0003761 47.0
TLS2_k127_13090_2 PFAM secretion protein HlyD family protein K01993,K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 413.0
TLS2_k127_13090_3 zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 376.0
TLS2_k127_13090_4 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000000000000000005964 130.0
TLS2_k127_13090_5 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000001214 109.0
TLS2_k127_13090_6 Diacylglycerol kinase catalytic domain K07029 GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.107 0.00000000000000003567 93.0
TLS2_k127_13090_7 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000002022 88.0
TLS2_k127_13090_8 Prokaryotic dksA/traR C4-type zinc finger - - - 0.00000000001472 70.0
TLS2_k127_13090_9 YCII-related domain - - - 0.00000002654 56.0
TLS2_k127_1344485_0 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 5.352e-259 812.0
TLS2_k127_1344485_1 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004942 337.0
TLS2_k127_1344485_2 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 311.0
TLS2_k127_1344485_3 Major facilitator Superfamily - - - 0.00000000000000000000000000000122 137.0
TLS2_k127_134916_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 7.15e-273 856.0
TLS2_k127_134916_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 448.0
TLS2_k127_134916_10 PFAM Stage II sporulation K06381 - - 0.000000000000000000000000000000000000000000000000000000000006579 222.0
TLS2_k127_134916_11 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000116 214.0
TLS2_k127_134916_12 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000126 216.0
TLS2_k127_134916_13 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000002293 167.0
TLS2_k127_134916_14 transcriptional regulator - - - 0.00000000000000000000000000000000000008542 150.0
TLS2_k127_134916_15 tRNA-binding protein K06878 - - 0.000000000000000000000000000000000005433 150.0
TLS2_k127_134916_16 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000336 136.0
TLS2_k127_134916_17 Zincin-like metallopeptidase - - - 0.000000000000000000000000001113 117.0
TLS2_k127_134916_18 protein transport K03210 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000002371 106.0
TLS2_k127_134916_19 Protein of unknown function (DUF2905) - - - 0.00000000000000005229 95.0
TLS2_k127_134916_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 438.0
TLS2_k127_134916_20 Protein conserved in bacteria - - - 0.000000000008733 70.0
TLS2_k127_134916_3 Family 5 K02035,K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008038 434.0
TLS2_k127_134916_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 399.0
TLS2_k127_134916_5 Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 313.0
TLS2_k127_134916_6 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033,K15581 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 300.0
TLS2_k127_134916_7 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 295.0
TLS2_k127_134916_8 SecD/SecF GG Motif K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002343 276.0
TLS2_k127_134916_9 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000124 255.0
TLS2_k127_1412492_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 1.176e-217 692.0
TLS2_k127_1412492_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 1.539e-194 621.0
TLS2_k127_1412492_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009965 520.0
TLS2_k127_1412492_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006844 436.0
TLS2_k127_1412492_4 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 383.0
TLS2_k127_1412492_5 TIGRFAM acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000001203 211.0
TLS2_k127_1412492_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000002311 208.0
TLS2_k127_1412492_7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000000001524 175.0
TLS2_k127_1412492_8 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000001694 163.0
TLS2_k127_1412492_9 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K21062 - 3.5.4.22 0.00000000000000000000000343 106.0
TLS2_k127_1422026_0 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 414.0
TLS2_k127_1422026_1 Belongs to the MurCDEF family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007418 289.0
TLS2_k127_1422026_2 Carbon-nitrogen hydrolase K01459 - 3.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000608 271.0
TLS2_k127_1422026_3 Fumarylacetoacetate (FAA) hydrolase family K14259 - 4.2.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000001836 250.0
TLS2_k127_1422026_4 Amidohydrolase family K01464 - 3.5.2.2 0.00000000000000000000000000000000000000000000000001517 202.0
TLS2_k127_1422026_5 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000007332 158.0
TLS2_k127_1433139_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 374.0
TLS2_k127_1433139_1 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008825 310.0
TLS2_k127_1433139_2 Methyltransferase domain K15942 - 2.1.1.288 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000813 302.0
TLS2_k127_1433139_3 PFAM Peptidase M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005401 305.0
TLS2_k127_1433139_4 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007007 282.0
TLS2_k127_1433139_5 Taurine catabolism dioxygenase TauD, TfdA family K06912 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003303 261.0
TLS2_k127_1433139_6 Acetohydroxy acid isomeroreductase, NADPH-binding domain K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000001802 228.0
TLS2_k127_1433139_7 Amidohydrolase K03392,K22213 - 4.1.1.45,4.1.1.52 0.0000000000000000000000000000000000000000000000000000001097 215.0
TLS2_k127_1433139_8 PFAM Cupin 2 conserved barrel domain protein - - - 0.000000000000000000000000001615 126.0
TLS2_k127_144021_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007717 622.0
TLS2_k127_144021_1 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008274 415.0
TLS2_k127_144021_11 manually curated - - - 0.00000000000000002791 82.0
TLS2_k127_144021_12 Sodium Bile acid symporter family - - - 0.000000000000005737 79.0
TLS2_k127_144021_13 Alkylmercury lyase K00221 - 4.99.1.2 0.000000004395 67.0
TLS2_k127_144021_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 369.0
TLS2_k127_144021_3 metal-dependent hydrolase of the TIM-barrel fold K03392,K22213 - 4.1.1.45,4.1.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000001629 269.0
TLS2_k127_144021_4 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.000000000000000000000000000000000000000000000000000000000000001391 226.0
TLS2_k127_144021_5 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000006068 192.0
TLS2_k127_144021_6 SnoaL-like polyketide cyclase K07255 - - 0.0000000000000000000000000000000000000000000000000000162 193.0
TLS2_k127_144021_7 C-terminal domain of 1-Cys peroxiredoxin - - - 0.00000000000000000000000000000000000000000000005892 173.0
TLS2_k127_144021_8 helix_turn_helix, mercury resistance K08365 - - 0.000000000000000000000000000006198 126.0
TLS2_k127_144021_9 Sodium Bile acid symporter family - - - 0.0000000000000000000000000002122 121.0
TLS2_k127_1464786_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000994 503.0
TLS2_k127_1464786_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16,6.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007364 487.0
TLS2_k127_1464786_2 PFAM ABC transporter related K02065 - - 0.00000000000000000000000000000000000000000000000000000000000002423 222.0
TLS2_k127_1464786_3 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000002974 213.0
TLS2_k127_1464786_4 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000002849 184.0
TLS2_k127_1464786_5 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.0000000000000000000000000000000000000000000000006394 183.0
TLS2_k127_1464786_6 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000002712 183.0
TLS2_k127_1464786_7 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.000000000000000000000000000000001141 133.0
TLS2_k127_1524241_0 Belongs to the IlvD Edd family K22396 - 4.2.1.82 6.143e-309 958.0
TLS2_k127_1524241_1 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 6.638e-290 898.0
TLS2_k127_1524241_10 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 322.0
TLS2_k127_1524241_11 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000718 255.0
TLS2_k127_1524241_12 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000002499 254.0
TLS2_k127_1524241_13 Ketopantoate reductase PanE/ApbA C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000003885 250.0
TLS2_k127_1524241_14 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000001384 226.0
TLS2_k127_1524241_15 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.000000000000000000000000000000000000000000000005186 191.0
TLS2_k127_1524241_16 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000001577 170.0
TLS2_k127_1524241_17 peroxiredoxin activity K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000001814 162.0
TLS2_k127_1524241_18 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.00000000000000000000000000000000005399 147.0
TLS2_k127_1524241_19 LysM domain K06194,K08259 - 3.4.24.75 0.000000000000000000000000001891 123.0
TLS2_k127_1524241_2 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 3.055e-241 786.0
TLS2_k127_1524241_20 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000000000009377 89.0
TLS2_k127_1524241_21 Redoxin K03386 - 1.11.1.15 0.00000000004992 67.0
TLS2_k127_1524241_22 Redoxin - - - 0.00000002132 58.0
TLS2_k127_1524241_23 NHL repeat - - - 0.000004562 58.0
TLS2_k127_1524241_3 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 1.089e-234 747.0
TLS2_k127_1524241_4 phosphonate ABC transporter, periplasmic phosphonate-binding protein K02044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 462.0
TLS2_k127_1524241_5 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008317 379.0
TLS2_k127_1524241_6 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 381.0
TLS2_k127_1524241_7 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 374.0
TLS2_k127_1524241_8 COG3639 ABC-type phosphate phosphonate transport system, permease component K02042 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 360.0
TLS2_k127_1524241_9 COG3639 ABC-type phosphate phosphonate transport system, permease component K02042 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006755 361.0
TLS2_k127_153368_0 Protein conserved in bacteria - - - 1.504e-200 644.0
TLS2_k127_153368_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 473.0
TLS2_k127_153368_10 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 340.0
TLS2_k127_153368_11 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 351.0
TLS2_k127_153368_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 322.0
TLS2_k127_153368_13 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004756 313.0
TLS2_k127_153368_14 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 302.0
TLS2_k127_153368_15 EH COG0115 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000001019 276.0
TLS2_k127_153368_16 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002564 256.0
TLS2_k127_153368_17 racemase activity, acting on amino acids and derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009382 256.0
TLS2_k127_153368_18 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002862 246.0
TLS2_k127_153368_19 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000006222 219.0
TLS2_k127_153368_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 467.0
TLS2_k127_153368_20 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000009474 211.0
TLS2_k127_153368_21 Belongs to the UPF0178 family K09768 - - 0.00000000000000000000000000000000000000000000000000000004275 199.0
TLS2_k127_153368_22 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000004814 168.0
TLS2_k127_153368_23 - - - - 0.0000000000000000000000000000000000000002119 164.0
TLS2_k127_153368_24 Protein of unknown function, DUF - - - 0.000000000000000000000000000000000000002798 148.0
TLS2_k127_153368_25 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000009597 147.0
TLS2_k127_153368_27 - - - - 0.000000000000000000000004865 108.0
TLS2_k127_153368_28 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - 0.000007568 55.0
TLS2_k127_153368_3 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 438.0
TLS2_k127_153368_4 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 413.0
TLS2_k127_153368_5 PFAM Rhodanese domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004883 415.0
TLS2_k127_153368_6 Belongs to the amidase family K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 385.0
TLS2_k127_153368_7 AIR synthase related protein, N-terminal domain K01933,K11788 GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 368.0
TLS2_k127_153368_8 translation release factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 372.0
TLS2_k127_153368_9 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 341.0
TLS2_k127_1536393_0 PFAM Cytochrome C assembly protein K02198 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 546.0
TLS2_k127_1536393_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 384.0
TLS2_k127_1536393_10 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02351 - - 0.00000000000000000000000000001665 123.0
TLS2_k127_1536393_11 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000002524 112.0
TLS2_k127_1536393_12 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 0.00000000000000000000008737 107.0
TLS2_k127_1536393_13 Ribosomal L32p protein family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.0000000000000000001821 89.0
TLS2_k127_1536393_14 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000005462 92.0
TLS2_k127_1536393_15 Cytochrome C and Quinol oxidase polypeptide I K00404 - 1.9.3.1 0.00000000000000009246 89.0
TLS2_k127_1536393_16 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.0000001947 63.0
TLS2_k127_1536393_17 peptidyl-tyrosine sulfation - - - 0.000007442 58.0
TLS2_k127_1536393_2 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009465 368.0
TLS2_k127_1536393_3 Cytochrome C assembly protein K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.0000000000000000000000000000000000000000000000000000000000004025 217.0
TLS2_k127_1536393_4 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000000000000003929 198.0
TLS2_k127_1536393_5 Thioredoxin-like K02199,K03671 - - 0.000000000000000000000000000000000000000000000000003008 208.0
TLS2_k127_1536393_6 Cytochrome c oxidase subunit K00404 - 1.9.3.1 0.00000000000000000000000000000000000000000000005004 183.0
TLS2_k127_1536393_7 PFAM cytochrome c-type biogenesis protein CcmB K02194 - - 0.00000000000000000000000000000000000000003028 165.0
TLS2_k127_1536393_8 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000003137 152.0
TLS2_k127_1536393_9 subunit of a heme lyase K02198,K02200 - - 0.0000000000000000000000000000003324 127.0
TLS2_k127_1557049_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1365.0
TLS2_k127_1557049_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 562.0
TLS2_k127_1557049_10 Iron-sulfur cluster assembly protein - - - 0.00000000000000000001348 103.0
TLS2_k127_1557049_11 Cysteine dioxygenase type I K00456 - 1.13.11.20 0.00000000000000000005317 104.0
TLS2_k127_1557049_12 PFAM regulatory protein, MarR - - - 0.000000000002198 74.0
TLS2_k127_1557049_2 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002861 391.0
TLS2_k127_1557049_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004463 376.0
TLS2_k127_1557049_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 336.0
TLS2_k127_1557049_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004629 283.0
TLS2_k127_1557049_6 Enoyl-CoA hydratase/isomerase K01661 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071890,GO:0071944,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000004772 273.0
TLS2_k127_1557049_7 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001422 267.0
TLS2_k127_1557049_8 Fe-S oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000005887 237.0
TLS2_k127_1557049_9 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000001329 224.0
TLS2_k127_1564276_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1232.0
TLS2_k127_1564276_1 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 1.79e-298 944.0
TLS2_k127_1564276_10 F420-dependent - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 410.0
TLS2_k127_1564276_11 Belongs to the thiolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006327 394.0
TLS2_k127_1564276_12 ATP dependent DNA ligase domain protein K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005056 389.0
TLS2_k127_1564276_13 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 364.0
TLS2_k127_1564276_14 Aminotransferase K03430 - 2.6.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 335.0
TLS2_k127_1564276_15 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 341.0
TLS2_k127_1564276_16 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004114 300.0
TLS2_k127_1564276_17 Sir2 family K12410 - - 0.0000000000000000000000000000000000000000000000000000000000001374 237.0
TLS2_k127_1564276_18 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000005084 236.0
TLS2_k127_1564276_19 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000003576 221.0
TLS2_k127_1564276_2 Thiamine pyrophosphate enzyme, central domain - - - 5.204e-256 802.0
TLS2_k127_1564276_20 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000001385 220.0
TLS2_k127_1564276_21 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000001125 214.0
TLS2_k127_1564276_22 PFAM Enoyl-CoA hydratase isomerase family K01715,K13766,K13767 - 4.2.1.17,4.2.1.18 0.0000000000000000000000000000000000000000000000000113 197.0
TLS2_k127_1564276_23 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000001058 191.0
TLS2_k127_1564276_24 Sodium:solute symporter family K03307 - - 0.00000000000000000000000000000000000000009297 168.0
TLS2_k127_1564276_25 Fumarylacetoacetate (FAA) hydrolase family K02554 - 4.2.1.80 0.00000000000000000000000000000000000000265 162.0
TLS2_k127_1564276_26 - - - - 0.000000000000000000000000000000000000008277 157.0
TLS2_k127_1564276_27 PFAM NUDIX hydrolase - - - 0.00000000000000000000000000000000000006023 151.0
TLS2_k127_1564276_28 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000001135 120.0
TLS2_k127_1564276_29 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000002627 108.0
TLS2_k127_1564276_3 Adenylate and Guanylate cyclase catalytic domain - - - 6.98e-255 823.0
TLS2_k127_1564276_30 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000002589 99.0
TLS2_k127_1564276_31 PFAM Abortive infection protein K07052 - - 0.0000000000000001646 89.0
TLS2_k127_1564276_32 PFAM GCN5-related N-acetyltransferase K00657 - 2.3.1.57 0.000000000001429 75.0
TLS2_k127_1564276_33 DoxX K15977 - - 0.000000000009567 76.0
TLS2_k127_1564276_4 4-alpha-glucanotransferase K00700,K00705,K02438,K06044 - 2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15 2.56e-202 647.0
TLS2_k127_1564276_5 TrkA-N domain K03455,K10716 - - 2.296e-194 625.0
TLS2_k127_1564276_6 PFAM type I phosphodiesterase nucleotide pyrophosphatase K19670 - 3.11.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004061 563.0
TLS2_k127_1564276_7 Sodium/hydrogen exchanger family K11105 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 567.0
TLS2_k127_1564276_8 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000726 437.0
TLS2_k127_1564276_9 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003893 449.0
TLS2_k127_1646110_0 von Willebrand factor (vWF) type A domain - - - 6.668e-205 657.0
TLS2_k127_1646110_1 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03404,K03405 - 6.6.1.1 1.862e-198 640.0
TLS2_k127_1646110_10 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000006074 171.0
TLS2_k127_1646110_11 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00226,K00254 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.3.5.2,1.3.98.1 0.0000000000000000000000000000000000005457 156.0
TLS2_k127_1646110_12 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000003749 148.0
TLS2_k127_1646110_13 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000008795 112.0
TLS2_k127_1646110_14 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.0000000000000000000002626 103.0
TLS2_k127_1646110_2 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000952 607.0
TLS2_k127_1646110_3 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 480.0
TLS2_k127_1646110_4 Protein of unknown function (DUF4197) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001113 258.0
TLS2_k127_1646110_5 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008495 250.0
TLS2_k127_1646110_6 xanthine dehydrogenase activity K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000007071 201.0
TLS2_k127_1646110_7 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000005591 189.0
TLS2_k127_1646110_8 - - - - 0.000000000000000000000000000000000000000000000001446 181.0
TLS2_k127_1646110_9 Major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000008497 177.0
TLS2_k127_1681554_0 PFAM multi antimicrobial extrusion protein MatE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 461.0
TLS2_k127_1681554_1 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 326.0
TLS2_k127_1681554_2 lipoprotein transporter activity K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001766 259.0
TLS2_k127_1681554_3 COG2755 Lysophospholipase L1 and related esterases K10804 GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 0.000000000000000000000000000000000000000000000000000003381 207.0
TLS2_k127_1681554_4 PFAM thioesterase superfamily K02614 - - 0.000000000000000000000000000000000000000000004101 169.0
TLS2_k127_1681554_5 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000002951 143.0
TLS2_k127_1681554_6 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000001994 137.0
TLS2_k127_172129_0 PFAM Methylated-DNA- protein -cysteine S-methyltransferase, DNA binding K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 491.0
TLS2_k127_172129_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 402.0
TLS2_k127_172129_10 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000000000000001521 184.0
TLS2_k127_172129_12 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000001483 116.0
TLS2_k127_172129_13 Cytochrome P450 - - - 0.00000000000000002417 88.0
TLS2_k127_172129_14 TIGRFAM cobaltochelatase, CobN subunit K02230 - 6.6.1.2 0.000000000301 72.0
TLS2_k127_172129_15 bacterial OsmY and nodulation domain K04065 - - 0.000000008732 68.0
TLS2_k127_172129_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 397.0
TLS2_k127_172129_3 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009845 382.0
TLS2_k127_172129_4 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009229 353.0
TLS2_k127_172129_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004554 329.0
TLS2_k127_172129_6 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006845 318.0
TLS2_k127_172129_7 NADPH-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004282 256.0
TLS2_k127_172129_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.0000000000000000000000000000000000000000000000000000000000000006586 222.0
TLS2_k127_172129_9 Putative glycolipid-binding K09957 - - 0.00000000000000000000000000000000000000000000000003102 186.0
TLS2_k127_1726153_0 High confidence in function and specificity - - - 6.163e-275 865.0
TLS2_k127_1726153_1 MacB-like periplasmic core domain K02004 - - 8.439e-241 780.0
TLS2_k127_1726153_10 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009413 266.0
TLS2_k127_1726153_11 Peptidoglycan-binding domain 1 protein K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002369 272.0
TLS2_k127_1726153_12 Sporulation initiation inhibitor protein Soj K03496 - - 0.00000000000000000000000000000000000000000000000000002818 203.0
TLS2_k127_1726153_13 - - - - 0.00000000000000000000000000000000000000000000000004625 186.0
TLS2_k127_1726153_15 Domain of unknown function (DUF3459) K01236 - 3.2.1.141 0.00000000000000000000000000000000000202 139.0
TLS2_k127_1726153_16 methyltransferase - - - 0.0000000000000000000000000001294 132.0
TLS2_k127_1726153_17 transmembrane transporter activity K02445,K07783 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000004902 118.0
TLS2_k127_1726153_18 Protein of unknown function (DUF3309) - - - 0.0000000000000000287 81.0
TLS2_k127_1726153_19 serine protease K07403 - - 0.0000000000003081 83.0
TLS2_k127_1726153_2 SMART alpha amylase, catalytic sub domain K05343 - 3.2.1.1,5.4.99.16 1.268e-230 734.0
TLS2_k127_1726153_20 bacterial OsmY and nodulation domain K04065 - - 0.0000000000004052 74.0
TLS2_k127_1726153_21 Belongs to the ompA family - - - 0.0000001818 61.0
TLS2_k127_1726153_22 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000006529 59.0
TLS2_k127_1726153_3 Alcohol dehydrogenase GroES-like domain K00055 - 1.1.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006915 524.0
TLS2_k127_1726153_4 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 509.0
TLS2_k127_1726153_5 Lipocalin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 443.0
TLS2_k127_1726153_6 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 389.0
TLS2_k127_1726153_7 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 361.0
TLS2_k127_1726153_8 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008699 337.0
TLS2_k127_1726153_9 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 323.0
TLS2_k127_1754326_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 5.592e-304 970.0
TLS2_k127_1754326_1 elongation factor G K02355 - - 2.42e-211 675.0
TLS2_k127_1754326_2 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006719 543.0
TLS2_k127_1754326_3 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 386.0
TLS2_k127_1754326_4 Sulfide dehydrogenase K05301,K17218 - 1.8.2.1,1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006082 379.0
TLS2_k127_1754326_5 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000958 283.0
TLS2_k127_1754326_6 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000007956 194.0
TLS2_k127_1754326_7 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000001028 100.0
TLS2_k127_1759531_0 branched-chain amino acid transport system, permease component K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008393 475.0
TLS2_k127_1759531_1 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008167 461.0
TLS2_k127_1759531_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000114 253.0
TLS2_k127_1759531_3 AAA domain, putative AbiEii toxin, Type IV TA system K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000002103 252.0
TLS2_k127_1759531_4 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000007156 231.0
TLS2_k127_1759531_5 Phosphotriesterase family - - - 0.00000000000000000000000000000000000000000000008019 184.0
TLS2_k127_1759531_6 PFAM Bacterial regulatory proteins, gntR family - - - 0.0000000000000000000000000000007912 131.0
TLS2_k127_1771282_0 undecaprenyl-phosphate glucose phosphotransferase activity K03606,K20997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 485.0
TLS2_k127_1771282_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 404.0
TLS2_k127_1771282_10 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.00000000000000000009376 104.0
TLS2_k127_1771282_11 PFAM NUDIX hydrolase - - - 0.000000000007508 75.0
TLS2_k127_1771282_12 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - 0.0000000001097 75.0
TLS2_k127_1771282_2 Polysaccharide biosynthesis protein K15856 - 1.1.1.281 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007924 363.0
TLS2_k127_1771282_3 fumarylacetoacetate (FAA) hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008146 273.0
TLS2_k127_1771282_4 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215,K03546 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000004873 257.0
TLS2_k127_1771282_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000001901 153.0
TLS2_k127_1771282_6 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.000000000000000000000000000000000008651 144.0
TLS2_k127_1771282_7 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.0000000000000000000000000000000001025 150.0
TLS2_k127_1771282_8 Predicted membrane protein (DUF2079) - - - 0.000000000000000000000000005165 130.0
TLS2_k127_1771282_9 O-Antigen ligase K18814 - - 0.000000000000000000000809 111.0
TLS2_k127_1875298_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 1.072e-225 715.0
TLS2_k127_1875298_1 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 378.0
TLS2_k127_1875298_10 - - - - 0.0000001424 64.0
TLS2_k127_1875298_2 tRNA synthetase class II core domain (G, H, P, S and T) K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 372.0
TLS2_k127_1875298_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 291.0
TLS2_k127_1875298_4 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000006189 235.0
TLS2_k127_1875298_5 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000008071 194.0
TLS2_k127_1875298_6 Involved in DNA repair and RecF pathway recombination K03474,K03584 GO:0008150,GO:0009314,GO:0009628,GO:0050896 2.6.99.2 0.0000000000000000000000000003731 124.0
TLS2_k127_1875298_7 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K01489,K07042 - 3.5.4.5 0.00000000000000000000114 105.0
TLS2_k127_1875298_8 Evidence 5 No homology to any previously reported sequences K03765 - - 0.0000000000000002993 93.0
TLS2_k127_1875298_9 Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000003378 70.0
TLS2_k127_1886606_0 Belongs to the amidase family K01426 - 3.5.1.4 1.743e-204 649.0
TLS2_k127_1886606_1 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009902 384.0
TLS2_k127_1886606_2 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 394.0
TLS2_k127_1886606_3 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001111 282.0
TLS2_k127_1886606_4 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000000000000000000000000000000000000001263 223.0
TLS2_k127_1886606_5 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000007344 191.0
TLS2_k127_1886606_6 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000002291 186.0
TLS2_k127_1886606_7 Integrase, catalytic region - - - 0.0000000000000000000000000002211 128.0
TLS2_k127_1908645_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 4.568e-236 754.0
TLS2_k127_1908645_1 phosphorelay signal transduction system K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006858 420.0
TLS2_k127_1908645_2 PFAM FAD linked oxidase domain protein K00102,K00104 - 1.1.2.4,1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 325.0
TLS2_k127_1908645_3 metal-dependent phosphohydrolase HD region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006061 263.0
TLS2_k127_1908645_4 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000001883 179.0
TLS2_k127_1908645_5 - - - - 0.0000000000000000000000000000048 133.0
TLS2_k127_1908645_6 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.0000000000000000003289 101.0
TLS2_k127_1908645_7 Nodulation protein S (NodS) - - - 0.000000001819 68.0
TLS2_k127_1926849_0 Thiamine pyrophosphate protein TPP binding domain protein K01652 - 2.2.1.6 4.301e-201 644.0
TLS2_k127_1926849_1 Cache domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 572.0
TLS2_k127_1926849_10 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004138 286.0
TLS2_k127_1926849_11 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 - 3.5.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001989 282.0
TLS2_k127_1926849_12 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000003766 242.0
TLS2_k127_1926849_13 Trehalose utilisation K15538,K21132 - 3.2.1.130,3.2.1.198 0.0000000000000000000000000000000000000000000000000000000000000156 235.0
TLS2_k127_1926849_14 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000002278 215.0
TLS2_k127_1926849_15 glutamine-fructose-6-phosphate transaminase (isomerizing) activity K00820,K15916 - 2.6.1.16,5.3.1.8,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000233 216.0
TLS2_k127_1926849_16 heat shock protein binding K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000001744 204.0
TLS2_k127_1926849_18 OHCU decarboxylase K13485 - 4.1.1.97 0.000000000000000000000000000000000000000000000003762 182.0
TLS2_k127_1926849_19 hydroxyisourate hydrolase activity K07127,K13485 GO:0003674,GO:0005488,GO:0005515,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009112,GO:0009987,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564 3.5.2.17,4.1.1.97 0.000000000000000000000000000000000005697 155.0
TLS2_k127_1926849_2 PFAM extracellular solute-binding protein family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 554.0
TLS2_k127_1926849_20 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00124 - - 0.00000000000000000000000000000000009693 154.0
TLS2_k127_1926849_21 Adenylyl- / guanylyl cyclase, catalytic domain K07814 - - 0.000000000000000000000000003132 130.0
TLS2_k127_1926849_22 transcriptional - - - 0.00000000000000000000004184 108.0
TLS2_k127_1926849_23 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000003431 109.0
TLS2_k127_1926849_24 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000003603 64.0
TLS2_k127_1926849_25 Major facilitator superfamily - - - 0.0000007481 62.0
TLS2_k127_1926849_26 - - - - 0.00008955 49.0
TLS2_k127_1926849_3 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000754 462.0
TLS2_k127_1926849_4 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 455.0
TLS2_k127_1926849_5 Aminotransferase class-V K00830,K00839 - 2.6.1.112,2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 431.0
TLS2_k127_1926849_6 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 407.0
TLS2_k127_1926849_7 aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 355.0
TLS2_k127_1926849_8 PFAM Acyl-CoA dehydrogenase K00248,K22430 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.3.1.108,1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 310.0
TLS2_k127_1926849_9 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004596 298.0
TLS2_k127_1950723_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 462.0
TLS2_k127_1950723_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 424.0
TLS2_k127_1950723_10 Evidence 4 Homologs of previously reported genes of K09700 - - 0.000000000000000000000000000009251 132.0
TLS2_k127_1950723_11 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07669,K07672 GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010446,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0023052,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0035556,GO:0043254,GO:0044087,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000001032 91.0
TLS2_k127_1950723_12 Tautomerase enzyme - - - 0.0000000000003462 72.0
TLS2_k127_1950723_2 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 394.0
TLS2_k127_1950723_3 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008409 297.0
TLS2_k127_1950723_4 glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000002508 254.0
TLS2_k127_1950723_5 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000005862 252.0
TLS2_k127_1950723_6 Fructose-1,6-bisphosphatase K01622 - 3.1.3.11,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000004148 222.0
TLS2_k127_1950723_7 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000007679 205.0
TLS2_k127_1950723_8 Encapsulating protein for peroxidase - - - 0.000000000000000000000000000000004845 143.0
TLS2_k127_1950723_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.0000000000000000000000000000004651 125.0
TLS2_k127_1961565_0 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004839 482.0
TLS2_k127_1961565_1 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000002508 255.0
TLS2_k127_1961565_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - GO:0003674,GO:0003824,GO:0004321,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009268,GO:0009628,GO:0010447,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051704,GO:0071944 - 0.00000001873 62.0
TLS2_k127_1961565_4 Predicted membrane protein (DUF2339) - - - 0.00000007062 60.0
TLS2_k127_1961565_5 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000111 59.0
TLS2_k127_1961565_6 - - - - 0.0002529 53.0
TLS2_k127_2024453_0 Phosphoenolpyruvate phosphomutase K01841 - 5.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004446 524.0
TLS2_k127_2024453_1 Belongs to the TPP enzyme family K09459 - 4.1.1.82 0.00000000000000000000000000000000000000000000003537 174.0
TLS2_k127_2024453_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000001526 168.0
TLS2_k127_2024453_3 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000001068 155.0
TLS2_k127_2024453_4 - - - - 0.0000000000000000000000001104 121.0
TLS2_k127_2024453_5 - K07018 - - 0.0000000000000000000000003877 116.0
TLS2_k127_2024453_6 Outer membrane lipoprotein - - - 0.00000000000000000000132 107.0
TLS2_k127_2024453_7 Belongs to the ompA family K03640 - - 0.00000000000001271 74.0
TLS2_k127_2024453_8 Putative zinc-finger - - - 0.0003573 49.0
TLS2_k127_2056373_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 3.032e-209 672.0
TLS2_k127_2056373_1 AMP-binding enzyme C-terminal domain K16876 - 6.2.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008657 512.0
TLS2_k127_2056373_10 mRNA cleavage and polyadenylation factor CLP1 P-loop K06947 - - 0.00000000000000000000000003541 119.0
TLS2_k127_2056373_11 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000000000001488 95.0
TLS2_k127_2056373_2 PFAM aminotransferase class I and II K00812,K10907 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 437.0
TLS2_k127_2056373_3 AMP-binding enzyme K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008857 337.0
TLS2_k127_2056373_4 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 336.0
TLS2_k127_2056373_5 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000003204 187.0
TLS2_k127_2056373_6 Belongs to the enoyl-CoA hydratase isomerase family K16880 - - 0.0000000000000000000000000000000000000000008233 175.0
TLS2_k127_2056373_7 Polyketide cyclase / dehydrase and lipid transport K09386 - - 0.00000000000000000000000000000000000001837 150.0
TLS2_k127_2056373_8 Methyltransferase K08316 - 2.1.1.171 0.00000000000000000000000000000000000002172 157.0
TLS2_k127_2056373_9 Protein conserved in bacteria - - - 0.00000000000000000000000000003689 126.0
TLS2_k127_208821_0 Carbamoyltransferase C-terminus K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 567.0
TLS2_k127_208821_1 lipopolysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 384.0
TLS2_k127_208821_2 PFAM Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006272 323.0
TLS2_k127_208821_3 TIGRFAM Hydrolase, ortholog 1, exosortase system type 1 associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 322.0
TLS2_k127_208821_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000007571 237.0
TLS2_k127_208821_5 protein-(glutamine-N5) methyltransferase activity K02493,K16868 - 2.1.1.265,2.1.1.297 0.0000000000000000000000000000001096 144.0
TLS2_k127_208821_6 LICD family K07271 - - 0.00000000000000004127 91.0
TLS2_k127_208821_7 Uncharacterised nucleotidyltransferase - - - 0.0000000001125 73.0
TLS2_k127_2119771_0 AMP-binding enzyme C-terminal domain - - - 5.702e-205 654.0
TLS2_k127_2119771_1 amino acid K03294,K19540 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 556.0
TLS2_k127_2119771_10 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002627 271.0
TLS2_k127_2119771_11 PFAM peptidase M48 Ste24p K06013 - 3.4.24.84 0.00000000000000000000000000000000000000000000000000000000000000000001423 246.0
TLS2_k127_2119771_12 Histidine phosphatase superfamily (branch 1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000008456 237.0
TLS2_k127_2119771_13 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000000000000000000000005033 227.0
TLS2_k127_2119771_14 phosphatidylinositol kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000003895 236.0
TLS2_k127_2119771_15 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.4.3.5 0.0000000000000000000000000000000000000000000003269 179.0
TLS2_k127_2119771_16 Pfam:DUF385 - - - 0.0000000000000000000000000000000000000000000004249 176.0
TLS2_k127_2119771_17 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000001837 172.0
TLS2_k127_2119771_18 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000001236 159.0
TLS2_k127_2119771_19 Protein of unknown function (DUF3090) - - - 0.000000000000000000000000283 120.0
TLS2_k127_2119771_2 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005392 542.0
TLS2_k127_2119771_20 - - - - 0.0000000000000000000005165 98.0
TLS2_k127_2119771_21 - - - - 0.0000000000000004617 83.0
TLS2_k127_2119771_22 Belongs to the 'phage' integrase family K03733,K04763 - - 0.00000000001663 75.0
TLS2_k127_2119771_23 COG NOG33517 non supervised orthologous group - - - 0.0000004588 55.0
TLS2_k127_2119771_24 Transposase IS116/IS110/IS902 family - - - 0.000003363 50.0
TLS2_k127_2119771_25 Protoglobin - - - 0.00001023 57.0
TLS2_k127_2119771_3 Mechanosensitive ion channel K16052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 449.0
TLS2_k127_2119771_4 Peptidase dimerisation domain K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 427.0
TLS2_k127_2119771_5 Histidine kinase K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007686 415.0
TLS2_k127_2119771_6 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 370.0
TLS2_k127_2119771_7 Sir2 family K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 304.0
TLS2_k127_2119771_8 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001305 276.0
TLS2_k127_2119771_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K20454 - 4.1.3.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001605 277.0
TLS2_k127_2130045_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 8.167e-214 683.0
TLS2_k127_2130045_1 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 408.0
TLS2_k127_2130045_10 NMT1/THI5 like K02051 - - 0.0000000000000000000000000000000000000000000000000000001087 208.0
TLS2_k127_2130045_11 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000005796 89.0
TLS2_k127_2130045_2 COG0402 Cytosine deaminase and related metal-dependent hydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006223 404.0
TLS2_k127_2130045_3 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 383.0
TLS2_k127_2130045_4 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004089 356.0
TLS2_k127_2130045_5 Aldehyde dehydrogenase family K00130 - 1.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009579 327.0
TLS2_k127_2130045_6 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004926 291.0
TLS2_k127_2130045_7 Carbon-nitrogen hydrolase K01431 - 3.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000002822 261.0
TLS2_k127_2130045_8 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002618 250.0
TLS2_k127_2130045_9 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000001606 233.0
TLS2_k127_2135124_0 III protein, CoA-transferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 399.0
TLS2_k127_2135124_1 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 330.0
TLS2_k127_2135124_10 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000006149 115.0
TLS2_k127_2135124_2 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003291 279.0
TLS2_k127_2135124_3 GTP cyclohydrolase I K00950,K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000004905 256.0
TLS2_k127_2135124_4 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000004462 244.0
TLS2_k127_2135124_5 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000000000000000001252 233.0
TLS2_k127_2135124_6 Molybdopterin converting factor subunit K03635,K21142 - 2.8.1.12 0.000000000000000000000000000000000000000000000000000000003995 206.0
TLS2_k127_2135124_7 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000648 186.0
TLS2_k127_2135124_8 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000009646 157.0
TLS2_k127_2135124_9 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000003927 115.0
TLS2_k127_2160351_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 1.817e-209 680.0
TLS2_k127_2160351_1 non-haem dioxygenase in morphine synthesis N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007769 392.0
TLS2_k127_2160351_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008414 321.0
TLS2_k127_2160351_3 3-demethylubiquinone-9 3-O-methyltransferase activity K06219 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001311 272.0
TLS2_k127_2160351_4 NIPSNAP - - - 0.00000000000000000000000000000004829 128.0
TLS2_k127_2160351_6 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000002239 97.0
TLS2_k127_2160351_7 - - - - 0.0000000000000856 73.0
TLS2_k127_2160351_8 - - - - 0.00002261 55.0
TLS2_k127_216444_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 1.609e-237 748.0
TLS2_k127_216444_1 PFAM Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 2.476e-215 681.0
TLS2_k127_216444_10 Evidence 5 No homology to any previously reported sequences K03765 - - 0.00000000008796 76.0
TLS2_k127_216444_11 Peptidoglycan-synthase activator LpoB - - - 0.000008291 56.0
TLS2_k127_216444_12 YtxH-like protein - - - 0.00003038 51.0
TLS2_k127_216444_2 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 452.0
TLS2_k127_216444_3 COG1960 Acyl-CoA dehydrogenases K19966 - 3.13.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 407.0
TLS2_k127_216444_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 382.0
TLS2_k127_216444_5 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 290.0
TLS2_k127_216444_6 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005254 293.0
TLS2_k127_216444_7 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000007261 190.0
TLS2_k127_216444_8 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000003049 197.0
TLS2_k127_216444_9 Putative regulatory protein - - - 0.0000000000000000007138 89.0
TLS2_k127_21662_0 alpha beta - - - 6.618e-264 854.0
TLS2_k127_21662_1 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008997 272.0
TLS2_k127_21662_2 bacterial OsmY and nodulation domain - - - 0.000000000003081 69.0
TLS2_k127_219569_0 Receptor family ligand binding region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 456.0
TLS2_k127_219569_1 non-haem dioxygenase in morphine synthesis N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 394.0
TLS2_k127_219569_2 Coenzyme A transferase K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004932 344.0
TLS2_k127_219569_3 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 316.0
TLS2_k127_219569_4 PFAM Coenzyme A transferase K01040 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001035 293.0
TLS2_k127_219569_5 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007789 259.0
TLS2_k127_219569_6 FCD - - - 0.000000000000000000000000000123 124.0
TLS2_k127_2214063_0 trehalose biosynthetic process K00700,K05343,K16146 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 4.906e-264 826.0
TLS2_k127_2214063_1 Domain of unknown function (DUF3416) K16147 - 2.4.99.16 4.641e-231 737.0
TLS2_k127_2214063_2 synthase K00705,K06044 GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 1.089e-215 688.0
TLS2_k127_2214063_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 429.0
TLS2_k127_2214063_4 PFAM Glycosyl transferases group 1 K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 375.0
TLS2_k127_2214063_5 Hydrogenase expression formation protein (HypE) K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 345.0
TLS2_k127_2214063_6 Glycosyl transferase family 2 K21349 - 2.4.1.268 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000057 299.0
TLS2_k127_2214063_7 Phosphotransferase enzyme family K00700,K05343,K16146 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001712 291.0
TLS2_k127_2214063_8 Glutamate formiminotransferase K00603 - 2.1.2.5 0.000000000000000000000000000000000000000000000000000004089 198.0
TLS2_k127_2214063_9 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000002112 145.0
TLS2_k127_2258905_0 Rubrerythrin K22405 - 1.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004304 589.0
TLS2_k127_2258905_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 471.0
TLS2_k127_2258905_10 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000319 167.0
TLS2_k127_2258905_11 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000009707 174.0
TLS2_k127_2258905_12 GDP-mannose mannosyl hydrolase activity K01515,K03574 - 3.6.1.13,3.6.1.55 0.00000000000000000000002632 114.0
TLS2_k127_2258905_13 COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3 - - - 0.00000000000000000000004737 110.0
TLS2_k127_2258905_14 - - - - 0.0000000000000000001024 92.0
TLS2_k127_2258905_15 Protein of unknown function (DUF983) - - - 0.0000000000000001533 84.0
TLS2_k127_2258905_2 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007242 383.0
TLS2_k127_2258905_3 Squalene/phytoene synthase K00801,K02291,K10208 GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 303.0
TLS2_k127_2258905_4 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000003098 282.0
TLS2_k127_2258905_5 PAC2 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001422 246.0
TLS2_k127_2258905_6 protein tyrosine kinase activity K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000006376 236.0
TLS2_k127_2258905_7 Cytochrome oxidase assembly protein K02259,K03110 - - 0.0000000000000000000000000000000000000000000000000000000008104 224.0
TLS2_k127_2258905_8 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000115 194.0
TLS2_k127_2258905_9 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000006037 186.0
TLS2_k127_2267658_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003952 550.0
TLS2_k127_2267658_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 492.0
TLS2_k127_2267658_2 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007489 347.0
TLS2_k127_2267658_3 PFAM Na Picotransporter K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 346.0
TLS2_k127_2267658_4 PFAM Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004468 299.0
TLS2_k127_2267658_5 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001831 271.0
TLS2_k127_2267658_6 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000005974 270.0
TLS2_k127_2267658_7 indole-3-glycerol-phosphate synthase activity K01609,K13498 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000003929 233.0
TLS2_k127_2267658_8 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000001075 178.0
TLS2_k127_2267658_9 Belongs to the phosphoglycerate mutase family - - - 0.000000000000000000000000000000006798 148.0
TLS2_k127_2283131_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046,K13797 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 3.336e-300 937.0
TLS2_k127_2283131_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 2.07e-294 918.0
TLS2_k127_2283131_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000008845 223.0
TLS2_k127_2283131_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000000000000000000000000000000001408 215.0
TLS2_k127_229160_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 8.614e-204 648.0
TLS2_k127_229160_1 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 372.0
TLS2_k127_229160_2 Domain of unknown function (DUF3482) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 346.0
TLS2_k127_229160_3 mannose-ethanolamine phosphotransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007032 298.0
TLS2_k127_229160_4 Redoxin K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005798 274.0
TLS2_k127_229160_5 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000004501 239.0
TLS2_k127_229160_6 Protein of unknown function (DUF2868) - - - 0.0000000000000000000000000000000000000000000000000000000001928 223.0
TLS2_k127_229160_7 Redoxin - - - 0.000000000000000000000000000000000000000002528 169.0
TLS2_k127_229160_8 Belongs to the Fur family K03711,K09825 - - 0.000000000000000000000006566 107.0
TLS2_k127_229160_9 DnaK suppressor protein K06204 - - 0.000000000001334 73.0
TLS2_k127_2333293_0 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 507.0
TLS2_k127_2333293_1 TRAP-type mannitol chloroaromatic compound transport system large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 513.0
TLS2_k127_2333293_10 DoxX K15977 - - 0.00000001383 67.0
TLS2_k127_2333293_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004936 349.0
TLS2_k127_2333293_3 PFAM Acetamidase Formamidase K01455 - 3.5.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007872 319.0
TLS2_k127_2333293_4 cellular water homeostasis K03442,K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 301.0
TLS2_k127_2333293_5 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000000000000000000000000000001701 186.0
TLS2_k127_2333293_6 COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.0000000000000000000000000000000000000000000000001642 197.0
TLS2_k127_2333293_7 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000002685 176.0
TLS2_k127_2333293_8 PFAM pyridoxamine 5'-phosphate oxidase-related - - - 0.00000000000000000000000000000006416 134.0
TLS2_k127_2333293_9 Putative restriction endonuclease - - - 0.0000000007493 62.0
TLS2_k127_2335712_0 TonB-dependent receptor K02014 - - 1.023e-208 671.0
TLS2_k127_2335712_1 FAD binding domain of DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 543.0
TLS2_k127_2335712_10 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001133 249.0
TLS2_k127_2335712_11 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002917 260.0
TLS2_k127_2335712_12 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000003337 202.0
TLS2_k127_2335712_13 tRNA methyltransferase complex GCD14 subunit - - - 0.0000000000000000000000000000000000000000000000000000004769 207.0
TLS2_k127_2335712_14 cytochrome - - - 0.0000000000000000000000000000000000000000007663 165.0
TLS2_k127_2335712_15 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000004496 139.0
TLS2_k127_2335712_16 Membrane-bound lysozyme-inhibitor of c-type lysozyme K09914 - - 0.0000000000000000000000002512 111.0
TLS2_k127_2335712_17 oxidoreductase activity K00274 - 1.4.3.4 0.0000001417 61.0
TLS2_k127_2335712_18 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.0000002412 62.0
TLS2_k127_2335712_19 Domain of unknown function (DUF1731) K07071 GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 - 0.0000395 46.0
TLS2_k127_2335712_2 PFAM AMP-dependent synthetase and ligase K14469 - 1.3.1.84,4.2.1.116,6.2.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 529.0
TLS2_k127_2335712_20 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0005876 47.0
TLS2_k127_2335712_3 FMN-dependent dehydrogenase K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 454.0
TLS2_k127_2335712_4 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 426.0
TLS2_k127_2335712_5 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003638 424.0
TLS2_k127_2335712_6 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 395.0
TLS2_k127_2335712_7 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005818 354.0
TLS2_k127_2335712_8 PFAM Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 310.0
TLS2_k127_2335712_9 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000175 287.0
TLS2_k127_238513_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 2.332e-210 666.0
TLS2_k127_238513_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 2.323e-197 648.0
TLS2_k127_238513_10 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase K02031,K02032,K13892 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004834 430.0
TLS2_k127_238513_11 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 376.0
TLS2_k127_238513_12 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 355.0
TLS2_k127_238513_13 PFAM glycosyl transferase group 1 K15521 - 2.4.1.250 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 356.0
TLS2_k127_238513_14 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 302.0
TLS2_k127_238513_15 Aldolase/RraA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009328 261.0
TLS2_k127_238513_16 PFAM Kelch motif - - - 0.0000000000000000000000000000000000000000000000000000000000000000102 240.0
TLS2_k127_238513_17 Ndr family K00433 - 1.11.1.10 0.0000000000000000000000000000000000000000000000000000000001507 224.0
TLS2_k127_238513_18 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000001121 226.0
TLS2_k127_238513_19 transferase activity, transferring glycosyl groups K20444 - - 0.00000000000000000000000000000000000000000000000001236 206.0
TLS2_k127_238513_2 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 554.0
TLS2_k127_238513_20 Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon K03709 - - 0.000000000000000000000000000000000000000000006573 171.0
TLS2_k127_238513_21 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.00000000000000000000000000000000000000000001853 182.0
TLS2_k127_238513_22 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000008851 166.0
TLS2_k127_238513_23 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000004737 158.0
TLS2_k127_238513_24 4Fe-4S binding domain K05524 - - 0.00000000000000000000000000000000000007409 143.0
TLS2_k127_238513_25 Putative regulatory protein - - - 0.000000000000000000000000000008197 124.0
TLS2_k127_238513_26 signal transduction histidine kinase - - - 0.000000000000000000000002932 116.0
TLS2_k127_238513_27 - - - - 0.0000000000000000000001621 109.0
TLS2_k127_238513_28 Oxidoreductase FAD-binding domain K16246 - - 0.00000000000000003947 94.0
TLS2_k127_238513_29 Acetyltransferase (GNAT) domain - - - 0.000000000004013 78.0
TLS2_k127_238513_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007227 540.0
TLS2_k127_238513_30 TPR repeat-containing protein - - - 0.0000000008137 69.0
TLS2_k127_238513_31 Formyl transferase - - - 0.000000001972 70.0
TLS2_k127_238513_32 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.0000005418 56.0
TLS2_k127_238513_33 COG0457 FOG TPR repeat - - - 0.000003302 57.0
TLS2_k127_238513_34 Rubredoxin-like zinc ribbon domain (DUF35_N) - - - 0.00001512 55.0
TLS2_k127_238513_4 PFAM binding-protein-dependent transport systems inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 493.0
TLS2_k127_238513_5 Oligopeptide/dipeptide transporter, C-terminal region K15583 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003497 466.0
TLS2_k127_238513_6 dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007636 458.0
TLS2_k127_238513_7 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 450.0
TLS2_k127_238513_8 Domains REC, sigma54 interaction, HTH8 K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 456.0
TLS2_k127_238513_9 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 411.0
TLS2_k127_2446996_0 ACT domain K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000707 510.0
TLS2_k127_2446996_1 homoserine dehydrogenase K00003 GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005419 475.0
TLS2_k127_2446996_2 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 465.0
TLS2_k127_2446996_3 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 359.0
TLS2_k127_2446996_4 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 312.0
TLS2_k127_2446996_5 PFAM Aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000007582 230.0
TLS2_k127_2446996_6 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000006911 213.0
TLS2_k127_2446996_7 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000000006607 138.0
TLS2_k127_2446996_8 photosystem II stabilization K00703,K02237,K02238 - 2.4.1.21 0.00000000000114 74.0
TLS2_k127_2464984_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02504,K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 556.0
TLS2_k127_2464984_1 Two component signalling adaptor domain K02487,K06596 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004883 541.0
TLS2_k127_2464984_10 Essential for recycling GMP and indirectly, cGMP K00942,K01591 GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8,4.1.1.23 0.000000000000000000000000000000000000000000000000000000000397 209.0
TLS2_k127_2464984_11 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000006311 196.0
TLS2_k127_2464984_12 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000004426 177.0
TLS2_k127_2464984_13 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000009961 159.0
TLS2_k127_2464984_14 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000007968 146.0
TLS2_k127_2464984_15 phosphorelay signal transduction system K02658 - - 0.00000000000000000000000000000002512 133.0
TLS2_k127_2464984_16 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 0.000000000000000000000000002337 118.0
TLS2_k127_2464984_17 Two component signalling adaptor domain K03408 - - 0.0000000009068 67.0
TLS2_k127_2464984_18 DNA-directed 5'-3' RNA polymerase activity K03060 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.00002194 55.0
TLS2_k127_2464984_19 diguanylate cyclase K02488 - 2.7.7.65 0.0005626 53.0
TLS2_k127_2464984_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004633 388.0
TLS2_k127_2464984_3 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 330.0
TLS2_k127_2464984_4 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 297.0
TLS2_k127_2464984_5 Methyl-accepting chemotaxis protein (MCP) signaling domain K02660 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001707 295.0
TLS2_k127_2464984_6 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002218 251.0
TLS2_k127_2464984_7 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000002439 231.0
TLS2_k127_2464984_8 PFAM YicC-like family, N-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000001967 220.0
TLS2_k127_2464984_9 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000000000000000000000000000000000000000001036 227.0
TLS2_k127_2490003_0 Carbamoyl-phosphate synthetase ammonia chain K01955 GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.0 1433.0
TLS2_k127_2490003_1 histidine kinase, HAMP K13598 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 542.0
TLS2_k127_2490003_10 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007738 344.0
TLS2_k127_2490003_11 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 351.0
TLS2_k127_2490003_12 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 323.0
TLS2_k127_2490003_13 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 290.0
TLS2_k127_2490003_14 COG0600 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000231 269.0
TLS2_k127_2490003_15 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535,K13599 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000001236 256.0
TLS2_k127_2490003_16 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000001679 243.0
TLS2_k127_2490003_17 HrcA protein C terminal domain K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000259 241.0
TLS2_k127_2490003_18 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000001703 235.0
TLS2_k127_2490003_19 Belongs to the Nudix hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000001834 225.0
TLS2_k127_2490003_2 response regulator K13599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 525.0
TLS2_k127_2490003_20 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000000004442 197.0
TLS2_k127_2490003_21 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000124 180.0
TLS2_k127_2490003_22 Metallo-beta-lactamase superfamily K13075 - 3.1.1.81 0.0000000000000000000000000000000000000000001781 165.0
TLS2_k127_2490003_23 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000000000008559 153.0
TLS2_k127_2490003_24 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000000000000000000000002338 130.0
TLS2_k127_2490003_25 Archease protein family (MTH1598/TM1083) - - - 0.0000000000000002578 90.0
TLS2_k127_2490003_26 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.000000000000001635 90.0
TLS2_k127_2490003_3 Belongs to the CarA family K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005987 498.0
TLS2_k127_2490003_4 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 486.0
TLS2_k127_2490003_5 Protein of unknown function (DUF1116) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 466.0
TLS2_k127_2490003_6 Belongs to the ATCase OTCase family K00608,K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 396.0
TLS2_k127_2490003_7 CoA-ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 391.0
TLS2_k127_2490003_8 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000982 374.0
TLS2_k127_2490003_9 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003241 363.0
TLS2_k127_2520804_0 PFAM Glycosyl transferase family 2 - - - 1.064e-311 976.0
TLS2_k127_2520804_1 Hydantoinase B/oxoprolinase - - - 6.998e-245 773.0
TLS2_k127_2520804_2 PFAM ABC transporter, transmembrane region K06147,K11085 - - 5.252e-216 707.0
TLS2_k127_2520804_3 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 325.0
TLS2_k127_2520804_4 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000007128 193.0
TLS2_k127_2520804_5 PFAM Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000597 181.0
TLS2_k127_2520804_6 polysaccharide catabolic process K03478 - 3.5.1.105 0.000000000000000000000000000000000000004527 156.0
TLS2_k127_2520804_7 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000003529 133.0
TLS2_k127_2520804_8 Methyltransferase type 11 - - - 0.000000000000000000000000001471 122.0
TLS2_k127_2520804_9 thiolester hydrolase activity - - - 0.000000000003401 73.0
TLS2_k127_253138_0 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K21417 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 519.0
TLS2_k127_253138_1 PFAM dehydrogenase E1 component K21416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005803 452.0
TLS2_k127_253138_10 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000001289 89.0
TLS2_k127_253138_11 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000002081 83.0
TLS2_k127_253138_12 Thioredoxin - - - 0.00000000326 67.0
TLS2_k127_253138_13 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00018 - 1.1.1.29 0.000005984 53.0
TLS2_k127_253138_2 Catalytic domain of components of various dehydrogenase complexes K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 420.0
TLS2_k127_253138_3 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003433 399.0
TLS2_k127_253138_4 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 332.0
TLS2_k127_253138_5 Bacterial periplasmic substrate-binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003584 284.0
TLS2_k127_253138_6 Related to alanyl-tRNA synthetase HxxxH domain K01872,K07050 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.00000000000000000000000000000000000000000000000000000006669 203.0
TLS2_k127_253138_7 Serine hydrolase K07002 - - 0.00000000000000000000000000000000000000000000000000000007049 213.0
TLS2_k127_253138_8 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000006204 184.0
TLS2_k127_253138_9 Methylmuconolactone methyl-isomerase - - - 0.00000000000000000000000000000000000000000001861 169.0
TLS2_k127_2554353_0 NAD synthase K01916 - 6.3.1.5 2.961e-201 673.0
TLS2_k127_2554353_1 ABC transporter substrate-binding protein K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006363 397.0
TLS2_k127_2554353_2 ABC transporter permease K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 302.0
TLS2_k127_2554353_3 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000006914 236.0
TLS2_k127_2563674_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K17686 - 3.6.3.4,3.6.3.54 1.203e-232 747.0
TLS2_k127_2563674_1 Ribonuclease E/G family K08300,K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 477.0
TLS2_k127_2563674_2 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 317.0
TLS2_k127_2563674_3 Diacylglycerol kinase catalytic domain - - - 0.00000000000000000000000000000000000000000000433 184.0
TLS2_k127_2563674_4 Metal-sensitive transcriptional repressor K21600 - - 0.0000000000000000000000000002895 127.0
TLS2_k127_2563674_5 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000002031 83.0
TLS2_k127_2563674_6 monooxygenase activity K00688 - 2.4.1.1 0.000000000000000815 78.0
TLS2_k127_2563674_7 PFAM Formiminotransferase K00603 - 2.1.2.5 0.0000000008497 64.0
TLS2_k127_2563674_8 Protein of unknown function (DUF2889) - - - 0.0002245 53.0
TLS2_k127_256496_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 2.159e-270 880.0
TLS2_k127_256496_1 Amino acid permease - - - 6.28e-203 649.0
TLS2_k127_256496_10 PFAM HNH endonuclease K07451 - - 0.000000000000000000000000000000000443 138.0
TLS2_k127_256496_11 rRNA binding K02963 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000001212 106.0
TLS2_k127_256496_12 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000002101 98.0
TLS2_k127_256496_13 TIGRFAM competence protein ComEA helix-hairpin-helix repeat K02237 - - 0.00000000000004525 77.0
TLS2_k127_256496_14 'Cold-shock' DNA-binding domain K03704 - - 0.0000000000009377 68.0
TLS2_k127_256496_15 Protein of unknown function (DUF971) - - - 0.00000007205 63.0
TLS2_k127_256496_2 ABC transporter K06022,K06158,K10834 - 3.6.3.29,3.6.3.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 552.0
TLS2_k127_256496_3 Fungal trichothecene efflux pump (TRI12) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 356.0
TLS2_k127_256496_4 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000001618 194.0
TLS2_k127_256496_5 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 0.00000000000000000000000000000000000000000001999 164.0
TLS2_k127_256496_6 pyridoxamine 5'-phosphate K07005 - - 0.0000000000000000000000000000000000000006073 156.0
TLS2_k127_256496_7 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000001245 151.0
TLS2_k127_256496_8 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000001894 140.0
TLS2_k127_256496_9 endonuclease III K01247 - 3.2.2.21 0.00000000000000000000000000000000007194 145.0
TLS2_k127_2569231_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 1.193e-194 614.0
TLS2_k127_2569231_1 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 559.0
TLS2_k127_2569231_10 Protein of unknown function (DUF1553) - - - 0.0004153 49.0
TLS2_k127_2569231_2 belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004595 530.0
TLS2_k127_2569231_3 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008395 377.0
TLS2_k127_2569231_4 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 366.0
TLS2_k127_2569231_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000001233 134.0
TLS2_k127_2569231_6 peroxiredoxin activity K01607 - 4.1.1.44 0.0000000000000000000000001385 109.0
TLS2_k127_2569231_7 Domain of unknown function (DUF4405) - - - 0.000000000000000000001316 104.0
TLS2_k127_2569231_8 COG0668 Small-conductance mechanosensitive channel - - - 0.000000000000000000005197 103.0
TLS2_k127_2569231_9 Acts as a magnesium transporter K06213 - - 0.0000000000000005881 92.0
TLS2_k127_2624269_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 2.066e-229 717.0
TLS2_k127_2624269_1 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 409.0
TLS2_k127_2624269_10 COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms - - - 0.000000000000000000000001593 114.0
TLS2_k127_2624269_11 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.000000000000000000003244 99.0
TLS2_k127_2624269_12 Universal stress protein K06149 - - 0.0000000000000000007028 94.0
TLS2_k127_2624269_13 Clostridial hydrophobic W - - - 0.00000000000000001175 97.0
TLS2_k127_2624269_14 - - - - 0.00000000000000004017 85.0
TLS2_k127_2624269_15 RNA recognition motif - - - 0.0000000000000001314 82.0
TLS2_k127_2624269_2 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004086 325.0
TLS2_k127_2624269_3 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000001057 238.0
TLS2_k127_2624269_4 cytochrome c nitrite reductase K15876 - - 0.00000000000000000000000000000000000000000000000000000000002302 209.0
TLS2_k127_2624269_5 acyl-CoA dehydrogenase activity - - - 0.00000000000000000000000000000000000000000007274 179.0
TLS2_k127_2624269_6 Hemerythrin HHE cation binding - - - 0.0000000000000000000000000000000000000000004467 165.0
TLS2_k127_2624269_7 Pas domain - - - 0.0000000000000000000000000000000000000002111 162.0
TLS2_k127_2624269_8 PFAM CBS domain K04767 - - 0.000000000000000000000000000000000009809 143.0
TLS2_k127_2624269_9 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000233 133.0
TLS2_k127_2625677_0 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 6.207e-222 708.0
TLS2_k127_2625677_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006479 431.0
TLS2_k127_2625677_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 331.0
TLS2_k127_2625677_3 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000095 168.0
TLS2_k127_2625677_4 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000004435 142.0
TLS2_k127_2625677_5 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000148 83.0
TLS2_k127_2625677_6 Bacteriophage replication gene A protein (GPA) - - - 0.0002061 44.0
TLS2_k127_2631720_0 Aminotransferase class-III K01845,K07257,K21585 - 2.6.1.111,5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 558.0
TLS2_k127_2631720_1 Cys/Met metabolism PLP-dependent enzyme K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 445.0
TLS2_k127_2631720_10 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001136 240.0
TLS2_k127_2631720_11 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000002816 251.0
TLS2_k127_2631720_12 PFAM acylneuraminate cytidylyltransferase K07257 - - 0.00000000000000000000000000000000000000000000000000000000000002794 238.0
TLS2_k127_2631720_13 B12 binding domain - - - 0.00000000000000000000000000000000000000004188 172.0
TLS2_k127_2631720_14 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000006626 160.0
TLS2_k127_2631720_15 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000005105 153.0
TLS2_k127_2631720_16 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000001416 138.0
TLS2_k127_2631720_17 Winged helix-turn-helix DNA-binding - - - 0.000000000000000000000000000003027 128.0
TLS2_k127_2631720_18 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000003187 133.0
TLS2_k127_2631720_2 carbamoyl transferase, NodU family K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 453.0
TLS2_k127_2631720_20 Glycosyl transferase 4-like domain - - - 0.000000000000000000000003477 120.0
TLS2_k127_2631720_21 pseudaminic acid biosynthesis-associated protein PseG - - - 0.000000000000000000000004226 109.0
TLS2_k127_2631720_22 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000001453 114.0
TLS2_k127_2631720_23 Bacterial transferase hexapeptide (six repeats) K18234 - - 0.00000000000000000002049 108.0
TLS2_k127_2631720_24 methyltransferase - - - 0.00000000000000000005565 101.0
TLS2_k127_2631720_25 polysaccharide biosynthetic process K03183,K15256 - 2.1.1.163,2.1.1.201 0.000000000000000001154 101.0
TLS2_k127_2631720_26 PFAM Methyltransferase domain K00568 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.1.1.222,2.1.1.64 0.0000000000003677 81.0
TLS2_k127_2631720_27 Methyltransferase domain - - - 0.000000002409 67.0
TLS2_k127_2631720_3 Polysaccharide biosynthesis protein K15894 - 4.2.1.115 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 436.0
TLS2_k127_2631720_4 Extracellular solute-binding protein, family 5 K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 436.0
TLS2_k127_2631720_5 acid synthase K01654 - 2.5.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005243 361.0
TLS2_k127_2631720_6 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 333.0
TLS2_k127_2631720_7 ABC transporter, ATP-binding protein K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005221 348.0
TLS2_k127_2631720_8 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002669 282.0
TLS2_k127_2636981_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 614.0
TLS2_k127_2636981_1 Amidohydrolase family K15358 - 3.5.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003906 435.0
TLS2_k127_2636981_10 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.0000000000000000000000000000000000004095 146.0
TLS2_k127_2636981_11 Regulatory protein GntR HTH K05799 - - 0.0000000000000000000000003119 114.0
TLS2_k127_2636981_12 Belongs to the ompA family - - - 0.0000000000000001706 89.0
TLS2_k127_2636981_13 - - - - 0.0000000000001737 79.0
TLS2_k127_2636981_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 408.0
TLS2_k127_2636981_3 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005488 353.0
TLS2_k127_2636981_4 asparagine synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 310.0
TLS2_k127_2636981_5 Amino acid synthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009904 250.0
TLS2_k127_2636981_6 PFAM Uncharacterised conserved protein UCP033563 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009235 256.0
TLS2_k127_2636981_7 Domain of unknown function (DUF3488) - - - 0.0000000000000000000000000000000000000000000000000000000000000000088 255.0
TLS2_k127_2636981_8 PFAM luciferase family protein - - - 0.00000000000000000000000000000000000000000000000185 192.0
TLS2_k127_2636981_9 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000529 166.0
TLS2_k127_265176_0 Bacterial transferase hexapeptide (six repeats) K13018 - 2.3.1.201 1.711e-195 623.0
TLS2_k127_265176_1 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 590.0
TLS2_k127_265176_2 O-Antigen ligase - - - 0.000000000000000000000000000000000000000000000000000000000000004163 237.0
TLS2_k127_265176_3 Polysaccharide export protein K01991 - - 0.00000000000000000000000000000000000000000000000000000000000003354 229.0
TLS2_k127_265176_4 PFAM PHP domain protein K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000002484 176.0
TLS2_k127_265176_5 Tetratricopeptide repeat - - - 0.0000000000000000000000001008 122.0
TLS2_k127_265176_6 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 - 0.000001071 61.0
TLS2_k127_267072_0 Histidine kinase-like ATPases - - - 3.37e-256 871.0
TLS2_k127_267072_1 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01895 - 6.2.1.1 5.813e-229 719.0
TLS2_k127_267072_10 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000002041 220.0
TLS2_k127_267072_11 Chromate resistance - - - 0.00000000000000000000000000000000000000000000000000002933 192.0
TLS2_k127_267072_12 - - - - 0.000000000000000000000000000000000000000000000000009434 191.0
TLS2_k127_267072_13 belongs to the thioredoxin family K03671,K03672 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.8 0.000000000000000000000000000000000000000000000000557 181.0
TLS2_k127_267072_14 sequence-specific DNA binding - - - 0.000000000000000000000000000000002135 139.0
TLS2_k127_267072_15 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.00000000000000000000000000000000224 143.0
TLS2_k127_267072_16 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase - - - 0.00000000000000000000000000000002728 130.0
TLS2_k127_267072_17 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000006045 94.0
TLS2_k127_267072_18 Dehydrogenase K21430 - - 0.0000000000000000003739 93.0
TLS2_k127_267072_19 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104,K03325,K03741,K03892,K18701 - 1.20.4.1,2.8.4.2,3.1.3.48 0.000000000000000006095 93.0
TLS2_k127_267072_2 N-terminal half of MaoC dehydratase - - - 3.755e-206 647.0
TLS2_k127_267072_20 PFAM Glucose Sorbosone dehydrogenase K21430 - - 0.0000000000001511 74.0
TLS2_k127_267072_21 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000006857 53.0
TLS2_k127_267072_22 ATP-binding region ATPase domain protein - - - 0.000005115 62.0
TLS2_k127_267072_3 COG2059 Chromate transport protein ChrA K07240 - - 3.361e-195 618.0
TLS2_k127_267072_4 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K03737 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 485.0
TLS2_k127_267072_5 PFAM aldo keto reductase K05882 - 1.1.1.91 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 458.0
TLS2_k127_267072_6 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 381.0
TLS2_k127_267072_7 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004015 287.0
TLS2_k127_267072_8 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003087 286.0
TLS2_k127_267072_9 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000004931 243.0
TLS2_k127_269240_0 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 2.862e-248 776.0
TLS2_k127_269240_1 cellulose binding - - - 2.955e-223 694.0
TLS2_k127_269240_10 Fatty acid desaturase K00508 - 1.14.19.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000697 275.0
TLS2_k127_269240_12 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000001165 224.0
TLS2_k127_269240_13 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000004244 226.0
TLS2_k127_269240_14 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000002838 214.0
TLS2_k127_269240_15 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000000000000000000000000004788 184.0
TLS2_k127_269240_16 - - - - 0.000000000000000000000000000000000000000009834 154.0
TLS2_k127_269240_17 YCII-related domain - - - 0.00000000000000000000000000000000000004554 147.0
TLS2_k127_269240_18 Mo-molybdopterin cofactor metabolic process K03636,K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000000001738 155.0
TLS2_k127_269240_19 Tim44 K15539 - - 0.000000000000000000000000000002394 130.0
TLS2_k127_269240_2 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 592.0
TLS2_k127_269240_20 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000331 56.0
TLS2_k127_269240_3 PFAM DNA primase small subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 590.0
TLS2_k127_269240_4 ATP dependent DNA ligase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007487 550.0
TLS2_k127_269240_5 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 514.0
TLS2_k127_269240_6 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 489.0
TLS2_k127_269240_7 Taurine catabolism dioxygenase TauD, TfdA family K06912 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 449.0
TLS2_k127_269240_8 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 357.0
TLS2_k127_269240_9 F420-dependent oxidoreductase, MSMEG_3544 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 301.0
TLS2_k127_2713304_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835 - 5.4.2.2 5.158e-239 759.0
TLS2_k127_2713304_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.601e-225 716.0
TLS2_k127_2713304_10 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 363.0
TLS2_k127_2713304_11 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000484 332.0
TLS2_k127_2713304_12 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 334.0
TLS2_k127_2713304_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007642 317.0
TLS2_k127_2713304_14 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 297.0
TLS2_k127_2713304_15 Amidohydrolase family K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000005593 289.0
TLS2_k127_2713304_16 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000009985 250.0
TLS2_k127_2713304_17 PFAM YdjC family protein K03478 - 3.5.1.105 0.000000000000000000000000000000000000000000000000000000000000002876 234.0
TLS2_k127_2713304_18 PFAM OsmC family protein - - - 0.000000000000000000000000000000000000000000000000000000000000004545 226.0
TLS2_k127_2713304_19 SelR domain K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000001176 228.0
TLS2_k127_2713304_2 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 8.606e-203 646.0
TLS2_k127_2713304_20 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000001362 196.0
TLS2_k127_2713304_21 Yhs domain-containing protein - - - 0.0000000000000000000000000000000000000000000001735 176.0
TLS2_k127_2713304_22 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000003538 128.0
TLS2_k127_2713304_23 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000001299 111.0
TLS2_k127_2713304_24 - - - - 0.0000000000008534 76.0
TLS2_k127_2713304_3 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 581.0
TLS2_k127_2713304_4 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 548.0
TLS2_k127_2713304_5 COG1062 Zn-dependent alcohol dehydrogenases, class III K00001,K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 472.0
TLS2_k127_2713304_6 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 477.0
TLS2_k127_2713304_7 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 447.0
TLS2_k127_2713304_8 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 434.0
TLS2_k127_2713304_9 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 377.0
TLS2_k127_2754581_0 PFAM acyl-CoA dehydrogenase domain protein K00255,K11731 - 1.3.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 515.0
TLS2_k127_2754581_1 Acyl- CoA dehydrogenase type 2 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 414.0
TLS2_k127_2754581_2 CoA-transferase family III K18702 - 2.8.3.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008381 308.0
TLS2_k127_2754581_3 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000002988 243.0
TLS2_k127_2754581_4 transmembrane transport - - - 0.0000000000000000000000000000000000000000000000000000001369 207.0
TLS2_k127_2754581_5 - - - - 0.0000000000000000000000000000000000000000000000002449 190.0
TLS2_k127_2754581_6 dehydratase - - - 0.0000000000000000000000000000000000000001292 160.0
TLS2_k127_2754581_7 PFAM Integrase catalytic - - - 0.00000000000000000000000000000002079 133.0
TLS2_k127_2754581_8 PFAM Haloacid dehalogenase domain protein hydrolase K07025 - - 0.00000000000000000004545 101.0
TLS2_k127_2754581_9 retrograde transport, endosome to Golgi K07095 - - 0.0001385 53.0
TLS2_k127_2781912_0 PFAM Enoyl-CoA hydratase isomerase K07516 - 1.1.1.35 3.268e-282 883.0
TLS2_k127_2781912_1 Gaf domain - - - 4.283e-204 661.0
TLS2_k127_2781912_10 Amino-transferase class IV K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000004419 266.0
TLS2_k127_2781912_11 Thioesterase K07107 - - 0.00000000000000000000000000000000000000000000000000000000686 216.0
TLS2_k127_2781912_12 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000000000000000000000002942 214.0
TLS2_k127_2781912_13 Belongs to the MurCDEF family K01924 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 0.000000000000000000000000000000000000000000000000001523 190.0
TLS2_k127_2781912_14 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000001539 113.0
TLS2_k127_2781912_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 557.0
TLS2_k127_2781912_3 ROK family K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006974 399.0
TLS2_k127_2781912_4 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 361.0
TLS2_k127_2781912_5 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005261 334.0
TLS2_k127_2781912_6 PFAM binding-protein-dependent transport systems inner membrane component K02033,K12369,K13890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006543 282.0
TLS2_k127_2781912_7 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007137 279.0
TLS2_k127_2781912_8 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004592 284.0
TLS2_k127_2781912_9 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003273 282.0
TLS2_k127_28091_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 4.139e-221 699.0
TLS2_k127_28091_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 548.0
TLS2_k127_28091_10 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000006488 232.0
TLS2_k127_28091_11 YbaK prolyl-tRNA synthetase associated region - - - 0.0000000000000000000000000000000000001029 158.0
TLS2_k127_28091_12 Acetyltransferase (GNAT) domain - - - 0.000000000000000000004147 101.0
TLS2_k127_28091_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000001307 101.0
TLS2_k127_28091_14 Polymer-forming cytoskeletal - - - 0.0000000000000000002659 97.0
TLS2_k127_28091_15 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000007118 61.0
TLS2_k127_28091_16 Peptidase family C25 - - - 0.00007813 49.0
TLS2_k127_28091_2 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 408.0
TLS2_k127_28091_3 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 404.0
TLS2_k127_28091_4 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 396.0
TLS2_k127_28091_5 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 326.0
TLS2_k127_28091_6 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007915 309.0
TLS2_k127_28091_7 transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 336.0
TLS2_k127_28091_8 Ketopantoate reductase PanE/ApbA C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007442 282.0
TLS2_k127_28091_9 ankyrin repeat K06867,K15503 - - 0.00000000000000000000000000000000000000000000000000000000000000000005358 256.0
TLS2_k127_2823009_0 lipopolysaccharide transport K22110 - - 0.0 1336.0
TLS2_k127_2823009_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 1.292e-295 926.0
TLS2_k127_2823009_2 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 1.35e-230 728.0
TLS2_k127_2823009_3 COG0500 SAM-dependent methyltransferases K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 363.0
TLS2_k127_2823009_4 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000002229 208.0
TLS2_k127_2823009_5 Thioredoxin-like domain K03671 - - 0.0000000000000000000000000000001708 127.0
TLS2_k127_2823009_6 DoxX K15977 - - 0.0000002973 64.0
TLS2_k127_2823009_7 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03635,K21142 - 2.8.1.12 0.00006391 50.0
TLS2_k127_2823009_8 PFAM Formiminotransferase-cyclodeaminase - - - 0.0001598 51.0
TLS2_k127_2838884_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 3.369e-277 869.0
TLS2_k127_2838884_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 499.0
TLS2_k127_2838884_10 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000001528 186.0
TLS2_k127_2838884_11 MaoC like domain - - - 0.000000000000000000000000000000000000000000001442 171.0
TLS2_k127_2838884_12 peptidase m48, ste24p - - - 0.00000000000000000000000000000000000000000002183 181.0
TLS2_k127_2838884_13 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000004695 163.0
TLS2_k127_2838884_14 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000002889 156.0
TLS2_k127_2838884_15 - - - - 0.0000428 51.0
TLS2_k127_2838884_16 N-terminal half of MaoC dehydratase - - - 0.00026 51.0
TLS2_k127_2838884_2 Acts as a magnesium transporter K06213 GO:0000287,GO:0003674,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015693,GO:0030001,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0070838,GO:0072511 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 494.0
TLS2_k127_2838884_3 Belongs to the UbiD family K16874 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 339.0
TLS2_k127_2838884_4 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000839 310.0
TLS2_k127_2838884_5 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000006397 269.0
TLS2_k127_2838884_6 peptide deformylase activity K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000003588 235.0
TLS2_k127_2838884_7 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000000000000000001894 225.0
TLS2_k127_2838884_8 COGs COG2912 conserved - - - 0.000000000000000000000000000000000000000000000000000004216 202.0
TLS2_k127_2838884_9 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000007515 211.0
TLS2_k127_2844362_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 6.163e-253 802.0
TLS2_k127_2844362_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 8.043e-206 645.0
TLS2_k127_2844362_10 Methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 463.0
TLS2_k127_2844362_11 TOBE domain K02010,K02052 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005167 419.0
TLS2_k127_2844362_12 hydrolases or acyltransferases, alpha beta hydrolase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 411.0
TLS2_k127_2844362_13 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 401.0
TLS2_k127_2844362_14 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 421.0
TLS2_k127_2844362_15 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 393.0
TLS2_k127_2844362_16 Binding-protein-dependent transport system inner membrane component K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 390.0
TLS2_k127_2844362_17 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 354.0
TLS2_k127_2844362_18 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 343.0
TLS2_k127_2844362_19 Phospholipase D Transphosphatidylase K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 315.0
TLS2_k127_2844362_2 Luciferase-like monooxygenase - - - 2.944e-204 642.0
TLS2_k127_2844362_20 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 305.0
TLS2_k127_2844362_21 nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008312 308.0
TLS2_k127_2844362_22 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008018 276.0
TLS2_k127_2844362_23 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001217 252.0
TLS2_k127_2844362_24 UTRA K02043 - - 0.00000000000000000000000000000000000000000000000000000000000001346 223.0
TLS2_k127_2844362_25 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000001933 227.0
TLS2_k127_2844362_26 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000002264 220.0
TLS2_k127_2844362_27 AroM protein K14591 - - 0.0000000000000000000000000000000000000000000000000000004216 201.0
TLS2_k127_2844362_28 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000296 175.0
TLS2_k127_2844362_29 lactate metabolic process - - - 0.00000000000000000000000000000000000006962 154.0
TLS2_k127_2844362_3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 4.308e-204 650.0
TLS2_k127_2844362_30 Sodium:sulfate symporter transmembrane region K03319,K09477,K11106,K14445 - - 0.0000000000000000000000000000000002999 149.0
TLS2_k127_2844362_31 Isochorismatase family - - - 0.00000000000000000000000000000194 130.0
TLS2_k127_2844362_32 PFAM OmpA MotB domain protein K03640 - - 0.000000000000000000001896 109.0
TLS2_k127_2844362_33 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000001859 89.0
TLS2_k127_2844362_34 phosphatase activity K07025,K20866 - 3.1.3.10 0.00000000000002269 87.0
TLS2_k127_2844362_35 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000005827 68.0
TLS2_k127_2844362_4 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 615.0
TLS2_k127_2844362_5 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain K03520,K11177 - 1.17.1.4,1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 605.0
TLS2_k127_2844362_6 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 512.0
TLS2_k127_2844362_7 Protein of unknown function (DUF917) K09703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000462 521.0
TLS2_k127_2844362_8 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003495 515.0
TLS2_k127_2844362_9 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 518.0
TLS2_k127_2908931_0 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 470.0
TLS2_k127_2908931_1 Sodium:sulfate symporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 499.0
TLS2_k127_2908931_10 Cupin domain - - - 0.00000000000000000000000000000000000000000001814 168.0
TLS2_k127_2908931_11 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000001487 165.0
TLS2_k127_2908931_12 Periplasmic binding protein domain K01999 - - 0.00000000000000000000000000000000008231 140.0
TLS2_k127_2908931_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000003161 120.0
TLS2_k127_2908931_2 DEAD/H associated K03724 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007368 415.0
TLS2_k127_2908931_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 358.0
TLS2_k127_2908931_4 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008853 346.0
TLS2_k127_2908931_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 323.0
TLS2_k127_2908931_6 branched-chain amino acid ABC transporter ATP-binding protein K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004825 280.0
TLS2_k127_2908931_7 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001248 248.0
TLS2_k127_2908931_8 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000005063 190.0
TLS2_k127_2908931_9 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000006554 191.0
TLS2_k127_2924_0 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 574.0
TLS2_k127_2924_1 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 394.0
TLS2_k127_2924_2 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 371.0
TLS2_k127_2924_3 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides K01465 - 3.5.2.3 0.0000000000000000000009963 100.0
TLS2_k127_2924_4 ATPases associated with a variety of cellular activities K01990 - - 0.000004207 49.0
TLS2_k127_2928219_0 Methylenetetrahydrofolate reductase K00297,K00547,K00548 - 1.5.1.20,2.1.1.10,2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 622.0
TLS2_k127_2928219_1 PFAM Cys Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009785 548.0
TLS2_k127_2928219_10 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000008849 231.0
TLS2_k127_2928219_11 HpcH/HpaI aldolase/citrate lyase family K02510,K12660 - 4.1.2.52,4.1.2.53 0.000000000000000000000000000000000000000000000000000000000007784 218.0
TLS2_k127_2928219_12 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000006321 210.0
TLS2_k127_2928219_13 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000000000003929 131.0
TLS2_k127_2928219_14 Methyltransferase type 11 - - - 0.0000000000000000000000000004272 124.0
TLS2_k127_2928219_15 AI-2E family transporter - - - 0.000000000000000000000001254 116.0
TLS2_k127_2928219_16 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000009689 103.0
TLS2_k127_2928219_17 hydroperoxide reductase activity - - - 0.0000000000000000000000173 102.0
TLS2_k127_2928219_18 PFAM Vitamin B12 dependent methionine synthase, activation - - - 0.0000000000000000000001295 110.0
TLS2_k127_2928219_19 - - - - 0.0000000000007076 78.0
TLS2_k127_2928219_2 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007793 521.0
TLS2_k127_2928219_20 MFS_1 like family - - - 0.000000000008723 78.0
TLS2_k127_2928219_21 Histidine kinase - - - 0.000000004788 59.0
TLS2_k127_2928219_22 monooxygenase activity K00688,K15760,K16157,K16242,K18223,K22353,K22357 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494 1.14.13.227,1.14.13.236,1.14.13.25,1.14.13.69,2.4.1.1 0.0009014 46.0
TLS2_k127_2928219_3 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 469.0
TLS2_k127_2928219_4 TOBE domain K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 396.0
TLS2_k127_2928219_5 Amidohydrolase family K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 347.0
TLS2_k127_2928219_6 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005611 253.0
TLS2_k127_2928219_7 Homocysteine S-methyltransferase K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000001085 244.0
TLS2_k127_2928219_8 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000003362 237.0
TLS2_k127_2928219_9 TOBE domain K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000004007 243.0
TLS2_k127_2935453_0 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009251 500.0
TLS2_k127_2935453_1 to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 452.0
TLS2_k127_2935453_2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 410.0
TLS2_k127_2935453_3 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 394.0
TLS2_k127_2935453_4 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006815 329.0
TLS2_k127_2935453_5 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000001203 259.0
TLS2_k127_2935453_6 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000005867 246.0
TLS2_k127_2935453_7 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.000000000000000000000000004346 115.0
TLS2_k127_2935453_8 - - - - 0.0009029 50.0
TLS2_k127_2945558_0 (ABC) transporter K15738 - - 3.716e-201 643.0
TLS2_k127_2945558_1 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 485.0
TLS2_k127_2945558_10 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.000000000000000000000000000000000000000000000000000005167 200.0
TLS2_k127_2945558_11 protein histidine kinase activity K02482,K14986 - 2.7.13.3 0.0000000000000000000000000000000000000000000006697 192.0
TLS2_k127_2945558_12 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000009052 162.0
TLS2_k127_2945558_13 Cold shock protein K03704 - - 0.000000000000000000000000005113 113.0
TLS2_k127_2945558_14 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.0000000000000000000000002977 107.0
TLS2_k127_2945558_15 Acetyltransferase (GNAT) domain - - - 0.00000000001416 74.0
TLS2_k127_2945558_16 ABC transporter substrate binding protein K01989 - - 0.00001179 58.0
TLS2_k127_2945558_17 Helix-turn-helix domain - - - 0.00004154 54.0
TLS2_k127_2945558_2 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009216 497.0
TLS2_k127_2945558_3 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008796 410.0
TLS2_k127_2945558_4 Glucokinase K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004557 334.0
TLS2_k127_2945558_5 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008813 280.0
TLS2_k127_2945558_6 Alanine-glyoxylate amino-transferase K05825 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000273 267.0
TLS2_k127_2945558_7 RNA methylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000007869 236.0
TLS2_k127_2945558_8 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000009508 257.0
TLS2_k127_2945558_9 NADP oxidoreductase, coenzyme f420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000001613 211.0
TLS2_k127_2956123_0 polar amino acid transport system K02028 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 334.0
TLS2_k127_2956123_1 Binding-protein-dependent transport system inner membrane component K02029 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 312.0
TLS2_k127_2956123_2 Binding-protein-dependent transport system inner membrane component K02029 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 284.0
TLS2_k127_2956123_3 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001722 284.0
TLS2_k127_2956123_4 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides K01464 - 3.5.2.2 0.0000000000000000000000000000000000000000000000000000000000000000003101 240.0
TLS2_k127_2956318_0 TRAP transporter, 4TM 12TM fusion protein - - - 3.368e-274 858.0
TLS2_k127_2956318_1 TRAP transporter, solute receptor (TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000754 347.0
TLS2_k127_2956318_2 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 340.0
TLS2_k127_2956318_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000007999 232.0
TLS2_k127_2956318_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000005274 224.0
TLS2_k127_2956318_5 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000002032 75.0
TLS2_k127_2958959_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 7.578e-238 751.0
TLS2_k127_2958959_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004412 460.0
TLS2_k127_2958959_2 adenylosuccinate lyase K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 415.0
TLS2_k127_2958959_3 Dolichyl-phosphate-mannose-protein mannosyltransferase K14340 - - 0.00000000000000002074 96.0
TLS2_k127_2958959_4 Membrane - - - 0.00000000008885 70.0
TLS2_k127_2958959_5 Major facilitator superfamily - - - 0.000000001412 61.0
TLS2_k127_2962532_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - 0.0 1145.0
TLS2_k127_2962532_1 Belongs to the ClpA ClpB family K03696 GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - 3.812e-297 926.0
TLS2_k127_2962532_10 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007531 309.0
TLS2_k127_2962532_11 ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000008077 275.0
TLS2_k127_2962532_12 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000002991 273.0
TLS2_k127_2962532_13 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000002771 243.0
TLS2_k127_2962532_14 Belongs to the peptidase M16 family K07263 - - 0.000000000000000000000000000000000000000000000000000000000000002248 237.0
TLS2_k127_2962532_15 (Rhomboid) family - - - 0.000000000000000000000000000000000000000000000000000000000000007723 240.0
TLS2_k127_2962532_16 PFAM Peptidase M16 inactive domain - - - 0.0000000000000000000000000000000000000000000000000000000000001155 235.0
TLS2_k127_2962532_17 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000009589 200.0
TLS2_k127_2962532_18 Lumazine binding domain K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000002159 180.0
TLS2_k127_2962532_19 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464 2.5.1.78 0.000000000000000000000000000000000000003408 152.0
TLS2_k127_2962532_2 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 593.0
TLS2_k127_2962532_20 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000004291 138.0
TLS2_k127_2962532_21 Helix-turn-helix domain - - - 0.000000000000000000009993 104.0
TLS2_k127_2962532_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 552.0
TLS2_k127_2962532_4 Required for chromosome condensation and partitioning K03529 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 525.0
TLS2_k127_2962532_5 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005075 407.0
TLS2_k127_2962532_6 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003447 385.0
TLS2_k127_2962532_7 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 354.0
TLS2_k127_2962532_8 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 345.0
TLS2_k127_2962532_9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 319.0
TLS2_k127_2995923_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 2.938e-254 811.0
TLS2_k127_2995923_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003344 263.0
TLS2_k127_2995923_2 Dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001292 244.0
TLS2_k127_2995923_3 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002652 243.0
TLS2_k127_2995923_4 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS K19819 - 1.5.99.4 0.00000000000000000000000000000000000000000000000002958 196.0
TLS2_k127_2995923_5 transcriptional K03710 - - 0.0000000000000000000000000000006875 135.0
TLS2_k127_2995923_6 oxidoreductase activity, acting on CH-OH group of donors K09386 - - 0.0000000000000000000000000009103 117.0
TLS2_k127_2995923_7 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000005713 68.0
TLS2_k127_3007643_0 Belongs to the ABC transporter superfamily K13896 - - 5.502e-240 753.0
TLS2_k127_3007643_1 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 2.82e-207 657.0
TLS2_k127_3007643_10 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004534 256.0
TLS2_k127_3007643_11 metal-dependent hydrolase with the TIM-barrel fold - - - 0.000000000000000000000000000000000000000000000000000000000000001418 235.0
TLS2_k127_3007643_12 N-terminal TM domain of oligopeptide transport permease C K13895 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000003574 149.0
TLS2_k127_3007643_13 B domain of TMEM189, localisation domain K20656 - - 0.00000000000000000000000000000000000003791 154.0
TLS2_k127_3007643_14 Endoribonuclease L-PSP - - - 0.0000000000000000000004058 109.0
TLS2_k127_3007643_15 translation initiation inhibitor, yjgF family - - - 0.000000000000000006134 96.0
TLS2_k127_3007643_16 Pfam:DUF385 - - - 0.00000000000000003384 85.0
TLS2_k127_3007643_17 Antibiotic biosynthesis monooxygenase - - - 0.0000000000003928 74.0
TLS2_k127_3007643_18 endoribonuclease L-PSP - - - 0.000000000000803 80.0
TLS2_k127_3007643_2 Belongs to the CinA family - - - 2.501e-201 642.0
TLS2_k127_3007643_20 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000003251 53.0
TLS2_k127_3007643_3 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed K00632 - 2.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 468.0
TLS2_k127_3007643_4 Phosphoenolpyruvate phosphomutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 381.0
TLS2_k127_3007643_5 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007464 355.0
TLS2_k127_3007643_6 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 351.0
TLS2_k127_3007643_7 NADP-dependent oxidoreductase K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006423 355.0
TLS2_k127_3007643_8 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 310.0
TLS2_k127_3007643_9 EamA-like transporter family K15268 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002845 282.0
TLS2_k127_3015044_0 UPF0365 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000892 512.0
TLS2_k127_3015044_1 ABC-type sugar transport system, permease component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002589 308.0
TLS2_k127_3015044_2 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001304 267.0
TLS2_k127_3015044_3 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001491 258.0
TLS2_k127_3015044_4 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000002185 236.0
TLS2_k127_3015044_5 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000004056 149.0
TLS2_k127_3015044_6 Thioredoxin - - - 0.0000000000000000000007207 102.0
TLS2_k127_3015751_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 2.064e-210 661.0
TLS2_k127_3015751_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 446.0
TLS2_k127_3015751_10 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000008465 153.0
TLS2_k127_3015751_11 Binds the 23S rRNA K02909 - - 0.0000000000000000000000000007632 116.0
TLS2_k127_3015751_12 - - - - 0.00000000002529 73.0
TLS2_k127_3015751_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004917 419.0
TLS2_k127_3015751_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005043 363.0
TLS2_k127_3015751_4 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765,K02502 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000007289 253.0
TLS2_k127_3015751_5 TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000005256 238.0
TLS2_k127_3015751_6 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000002053 232.0
TLS2_k127_3015751_7 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000006658 221.0
TLS2_k127_3015751_8 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.00000000000000000000000000000000000000000000000000003616 208.0
TLS2_k127_3015751_9 Histidine biosynthesis bifunctional protein HisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000004103 205.0
TLS2_k127_3093522_0 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003648 535.0
TLS2_k127_3093522_1 Mandelate Racemase Muconate Lactonizing - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 529.0
TLS2_k127_3093522_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 350.0
TLS2_k127_3093522_3 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009528 292.0
TLS2_k127_3093522_4 alpha beta alpha domain I K01840,K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000002219 255.0
TLS2_k127_3093522_5 Inositol monophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000003137 232.0
TLS2_k127_3093522_6 quinone binding K12057,K22278 - 3.5.1.104 0.0000000000000000000000000000000000000002814 160.0
TLS2_k127_3093522_7 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.00000000000000000000000002801 123.0
TLS2_k127_3093522_8 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000001477 72.0
TLS2_k127_3111167_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 1.561e-224 741.0
TLS2_k127_3111167_1 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006016 541.0
TLS2_k127_3111167_10 Oxygenase, catalysing oxidative methylation of damaged DNA K09990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 299.0
TLS2_k127_3111167_11 Binding-protein-dependent transport system inner membrane component K02025,K10237,K15771 GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - 0.000000000000000000000000000000000000000000000000000000000000000000009792 259.0
TLS2_k127_3111167_12 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000002223 227.0
TLS2_k127_3111167_13 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000299 209.0
TLS2_k127_3111167_14 - - - - 0.0000000000000000000000000000000000000000000000000000736 192.0
TLS2_k127_3111167_15 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000002719 199.0
TLS2_k127_3111167_16 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000007505 190.0
TLS2_k127_3111167_17 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000005346 166.0
TLS2_k127_3111167_18 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000004392 167.0
TLS2_k127_3111167_19 ATP-grasp domain - - - 0.0000000000000000000000000000000000003776 156.0
TLS2_k127_3111167_2 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 482.0
TLS2_k127_3111167_20 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000006527 139.0
TLS2_k127_3111167_21 PFAM ABC transporter related K01995 - - 0.0000000000000000000000000002939 115.0
TLS2_k127_3111167_22 PFAM Cyclic nucleotide-binding - - - 0.00000000000000000006446 95.0
TLS2_k127_3111167_23 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000004969 81.0
TLS2_k127_3111167_24 isomerase activity - - - 0.00001374 58.0
TLS2_k127_3111167_3 Sulfate permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003734 467.0
TLS2_k127_3111167_4 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004188 392.0
TLS2_k127_3111167_5 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 373.0
TLS2_k127_3111167_6 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 355.0
TLS2_k127_3111167_7 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 357.0
TLS2_k127_3111167_8 Bacterial extracellular solute-binding protein K02027,K10236 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 342.0
TLS2_k127_3111167_9 endonuclease activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 313.0
TLS2_k127_3153966_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 5.89e-197 623.0
TLS2_k127_3153966_1 Metallopeptidase family M24 K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 315.0
TLS2_k127_3153966_10 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000007201 192.0
TLS2_k127_3153966_11 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000000000000000008042 185.0
TLS2_k127_3153966_12 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000003045 188.0
TLS2_k127_3153966_13 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000001119 174.0
TLS2_k127_3153966_14 CBS domain - - - 0.000000000000000000000000000000000000000000001464 171.0
TLS2_k127_3153966_15 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000005671 153.0
TLS2_k127_3153966_16 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000002963 140.0
TLS2_k127_3153966_17 PFAM ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000005672 142.0
TLS2_k127_3153966_18 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000009934 138.0
TLS2_k127_3153966_19 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000006562 134.0
TLS2_k127_3153966_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005109 277.0
TLS2_k127_3153966_20 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000001089 99.0
TLS2_k127_3153966_21 Belongs to the bacterial ribosomal protein bL36 family K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000003325 68.0
TLS2_k127_3153966_22 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) K02907 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000002268 61.0
TLS2_k127_3153966_3 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001621 273.0
TLS2_k127_3153966_4 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001018 264.0
TLS2_k127_3153966_5 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000002592 251.0
TLS2_k127_3153966_6 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001142 261.0
TLS2_k127_3153966_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000003938 249.0
TLS2_k127_3153966_8 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000009376 214.0
TLS2_k127_3153966_9 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000006318 206.0
TLS2_k127_3171852_0 COG4166 ABC-type oligopeptide transport system, periplasmic component K13893 - - 8.657e-252 795.0
TLS2_k127_3171852_1 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 3.047e-200 652.0
TLS2_k127_3171852_2 transport system, permease component K13894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 550.0
TLS2_k127_3171852_3 transport system, permease component K13895 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 503.0
TLS2_k127_3171852_4 Cell shape determining protein MreB Mrl K03569 GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009904 413.0
TLS2_k127_3171852_5 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 404.0
TLS2_k127_3171852_6 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 295.0
TLS2_k127_3171852_7 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000007276 196.0
TLS2_k127_3171852_8 - - - - 0.000000000000000000000000000000007193 133.0
TLS2_k127_3171852_9 Membrane K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000006586 75.0
TLS2_k127_3185927_0 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 523.0
TLS2_k127_3185927_1 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006499 435.0
TLS2_k127_3185927_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003792 303.0
TLS2_k127_3185927_3 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002324 281.0
TLS2_k127_3185927_4 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000002726 236.0
TLS2_k127_3185927_5 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000002554 203.0
TLS2_k127_3185927_6 regulation of translation K03530 - - 0.00000000000000000000000000002965 119.0
TLS2_k127_3185927_7 Bacterial regulatory protein, Fis family K07715 - - 0.00000000000000000000000000004122 133.0
TLS2_k127_3185927_8 PFAM ATP-binding region ATPase domain protein K10125 - 2.7.13.3 0.00000000000000000000004512 114.0
TLS2_k127_3190578_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789,K18138 - - 0.0 1318.0
TLS2_k127_3190578_1 BadF/BadG/BcrA/BcrD ATPase family - - - 0.0 1065.0
TLS2_k127_3190578_10 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 301.0
TLS2_k127_3190578_11 AIR synthase related protein, N-terminal domain K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 293.0
TLS2_k127_3190578_12 ATPase BadF BadG BcrA BcrD type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003161 287.0
TLS2_k127_3190578_13 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002029 266.0
TLS2_k127_3190578_14 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005823 267.0
TLS2_k127_3190578_15 transport system periplasmic component K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008576 254.0
TLS2_k127_3190578_16 copper-translocating P-type ATPase K01533 - 3.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000001763 226.0
TLS2_k127_3190578_17 dTDP biosynthetic process K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000001026 207.0
TLS2_k127_3190578_18 Haem-degrading - - - 0.000000000000000000000000000000000000000000005155 169.0
TLS2_k127_3190578_19 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000007724 155.0
TLS2_k127_3190578_2 4 iron, 4 sulfur cluster binding - - - 7.911e-223 700.0
TLS2_k127_3190578_20 CBS domain - - - 0.0000000000000000000000000000502 131.0
TLS2_k127_3190578_21 - - - - 0.00000000000000000000000139 121.0
TLS2_k127_3190578_22 SnoaL-like domain - - - 0.00000000009452 72.0
TLS2_k127_3190578_23 PFAM SNARE associated Golgi protein - - - 0.0000000005095 71.0
TLS2_k127_3190578_24 Amidohydrolase K07045 - - 0.00001457 51.0
TLS2_k127_3190578_3 Binding-protein-dependent transport system inner membrane component K02011 - - 2.213e-218 691.0
TLS2_k127_3190578_4 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain - - - 3.506e-205 667.0
TLS2_k127_3190578_5 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004424 532.0
TLS2_k127_3190578_6 TOBE domain K02010,K02052 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008841 379.0
TLS2_k127_3190578_7 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 360.0
TLS2_k127_3190578_8 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004397 336.0
TLS2_k127_3190578_9 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K11072 - 3.6.3.30,3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 317.0
TLS2_k127_3283536_0 Dehydrogenase E1 component K00164 - 1.2.4.2 1.256e-291 923.0
TLS2_k127_3283536_1 Xanthine dehydrogenase K03520 - 1.2.5.3 8.148e-285 900.0
TLS2_k127_3283536_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 473.0
TLS2_k127_3283536_3 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007035 421.0
TLS2_k127_3283536_4 AAA domain K07028 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 400.0
TLS2_k127_3283536_5 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 409.0
TLS2_k127_3283536_6 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004203 329.0
TLS2_k127_3283536_7 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000001083 228.0
TLS2_k127_3283536_8 ABC transporter substrate binding protein K01989 - - 0.0000000004308 72.0
TLS2_k127_3294609_0 Periplasmic binding protein domain K01999 - - 3.638e-206 652.0
TLS2_k127_3294609_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 366.0
TLS2_k127_3294609_10 Belongs to the UPF0109 family K06960 - - 0.00000000001837 64.0
TLS2_k127_3294609_2 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 344.0
TLS2_k127_3294609_3 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000796 331.0
TLS2_k127_3294609_4 Belongs to the RNA methyltransferase TrmD family K00554,K01770 GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 293.0
TLS2_k127_3294609_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000005623 216.0
TLS2_k127_3294609_6 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000000007007 158.0
TLS2_k127_3294609_7 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000004886 120.0
TLS2_k127_3294609_8 Isochorismatase family - - - 0.00000000000000000000000001929 119.0
TLS2_k127_3294609_9 Belongs to the UPF0102 family K07460 - - 0.0000000000000000006832 100.0
TLS2_k127_3325481_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 450.0
TLS2_k127_3325481_1 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000463 377.0
TLS2_k127_3325481_10 SUF system FeS assembly protein, NifU family K04488 - - 0.0000000000000000002023 93.0
TLS2_k127_3325481_11 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0000000000001179 71.0
TLS2_k127_3325481_2 Belongs to the arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002271 326.0
TLS2_k127_3325481_3 xanthine dehydrogenase activity K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006176 310.0
TLS2_k127_3325481_4 VWA domain containing CoxE-like protein K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003852 311.0
TLS2_k127_3325481_5 XdhC and CoxI family K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000001346 238.0
TLS2_k127_3325481_6 'Molybdopterin - - - 0.000000000000000000000000000000000000000000000000000000001168 222.0
TLS2_k127_3325481_7 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K19647 - 1.1.1.291,1.1.1.31 0.00000000000000000000000000000000000000000000000000002533 199.0
TLS2_k127_3325481_8 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family K02503 - - 0.000000000000000000000000000000005507 134.0
TLS2_k127_3325481_9 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.0000000000000000000000000000001963 141.0
TLS2_k127_3327829_0 benzoyl-CoA oxygenase - - - 8.357e-234 729.0
TLS2_k127_3327829_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K04105,K04110 - 6.2.1.25,6.2.1.27 1.373e-214 677.0
TLS2_k127_3327829_2 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 441.0
TLS2_k127_3327829_3 Endoribonuclease L-PSP - - - 0.0000000000000000000009323 103.0
TLS2_k127_3335356_0 Carboxyl transferase domain - - - 3.199e-240 757.0
TLS2_k127_3335356_1 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 527.0
TLS2_k127_3335356_2 Rieske 2Fe-2S domain protein K16319,K18074,K18242 - 1.14.12.1,1.14.12.15,1.14.13.172 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 518.0
TLS2_k127_3335356_3 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 342.0
TLS2_k127_3335356_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007835 301.0
TLS2_k127_3335356_5 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000121 304.0
TLS2_k127_3335356_6 Ring hydroxylating beta subunit K16320 - 1.14.12.1 0.0000000000000000000000000000000000000000000000000004964 190.0
TLS2_k127_3346646_0 Gamma-glutamyltranspeptidase - - - 5.374e-215 686.0
TLS2_k127_3346646_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K15868 - 6.2.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 562.0
TLS2_k127_3346646_10 - - - - 0.000000000000000000000000000000000000000000001172 180.0
TLS2_k127_3346646_11 Transport permease protein - - - 0.00000000000000000000000000000000006459 135.0
TLS2_k127_3346646_12 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.0000000000000000000000000000002342 132.0
TLS2_k127_3346646_13 RNA recognition motif - - - 0.0000000000000000000000009975 109.0
TLS2_k127_3346646_2 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003899 502.0
TLS2_k127_3346646_3 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 447.0
TLS2_k127_3346646_4 amino acid transport K09969 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 391.0
TLS2_k127_3346646_5 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 405.0
TLS2_k127_3346646_6 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 384.0
TLS2_k127_3346646_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 342.0
TLS2_k127_3346646_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000002756 204.0
TLS2_k127_3346646_9 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000003933 207.0
TLS2_k127_3428037_0 GTP-binding protein TypA K06207 - - 1.391e-248 786.0
TLS2_k127_3428037_1 Belongs to the heme-copper respiratory oxidase family K02274 - 1.9.3.1 2.275e-222 710.0
TLS2_k127_3428037_10 Cytochrome C and Quinol oxidase polypeptide I - - - 0.0000000000000000000000000004656 118.0
TLS2_k127_3428037_11 CoA binding domain - - - 0.0000000000000000000000003607 112.0
TLS2_k127_3428037_12 Cytochrome c K02305,K07152 - - 0.000000000001066 81.0
TLS2_k127_3428037_2 Belongs to the aldehyde dehydrogenase family K00128,K00138 - 1.2.1.3 2.496e-198 629.0
TLS2_k127_3428037_3 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 445.0
TLS2_k127_3428037_4 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 435.0
TLS2_k127_3428037_5 cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000001564 199.0
TLS2_k127_3428037_6 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768,K09565 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 0.00000000000000000000000000000000000000000000000000001499 192.0
TLS2_k127_3428037_7 peptidyl-prolyl cis-trans isomerase K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000002809 180.0
TLS2_k127_3428037_8 MaoC like domain - - - 0.0000000000000000000000000000000000001186 163.0
TLS2_k127_3428037_9 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000000001916 163.0
TLS2_k127_3504962_0 ABC transporter transmembrane region K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009212 512.0
TLS2_k127_3504962_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 479.0
TLS2_k127_3504962_10 Belongs to the bacterial solute-binding protein 3 family - - - 0.00000000000000000000000000000004324 136.0
TLS2_k127_3504962_11 Binding-protein-dependent transport system inner membrane component K02029 - - 0.000000000000000000002034 107.0
TLS2_k127_3504962_12 response regulator receiver K02481 - - 0.000000000000000000002058 98.0
TLS2_k127_3504962_13 Transcriptional regulatory protein, C terminal K07669,K07672 - - 0.000000000007128 73.0
TLS2_k127_3504962_14 CoA-transferase activity K01039 - 2.8.3.12 0.00000000001238 72.0
TLS2_k127_3504962_15 PFAM peptidase - - - 0.000778 46.0
TLS2_k127_3504962_2 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 343.0
TLS2_k127_3504962_3 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 330.0
TLS2_k127_3504962_4 Winged helix DNA-binding domain K09927 - - 0.00000000000000000000000000000000000000000000000000000000000000000000678 250.0
TLS2_k127_3504962_5 Acyl CoA acetate 3-ketoacid CoA transferase beta subunit K01040 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000002976 219.0
TLS2_k127_3504962_6 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000003462 173.0
TLS2_k127_3504962_7 membrane - - - 0.00000000000000000000000000000000000001067 153.0
TLS2_k127_3504962_8 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.000000000000000000000000000000000744 136.0
TLS2_k127_3504962_9 Binding-protein-dependent transport system inner membrane component K02029 - - 0.000000000000000000000000000000001477 138.0
TLS2_k127_3509940_0 PFAM aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 6.208e-311 977.0
TLS2_k127_3509940_1 Molybdopterin oxidoreductase Fe4S4 domain - - - 1.969e-265 833.0
TLS2_k127_3509940_10 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 342.0
TLS2_k127_3509940_11 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000001362 224.0
TLS2_k127_3509940_12 HupE / UreJ protein K03192 - - 0.0000000000000000000000000000000000000000001137 177.0
TLS2_k127_3509940_13 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00042 - 1.1.1.60 0.0000000000000000000000000000000000000001795 168.0
TLS2_k127_3509940_14 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000001089 114.0
TLS2_k127_3509940_15 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases K22441 - 2.3.1.57 0.0000000000000000000004993 108.0
TLS2_k127_3509940_16 - - - - 0.0000000000000000005618 100.0
TLS2_k127_3509940_17 Nitroreductase family - - - 0.000000000000000001826 96.0
TLS2_k127_3509940_18 Serine aminopeptidase, S33 - - - 0.000000000000004349 89.0
TLS2_k127_3509940_19 Sigma-54 interaction domain - - - 0.00001579 49.0
TLS2_k127_3509940_2 peptidase, M20 - - - 1.34e-208 663.0
TLS2_k127_3509940_3 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 516.0
TLS2_k127_3509940_4 Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities K00842,K14155 - 4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 461.0
TLS2_k127_3509940_5 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 427.0
TLS2_k127_3509940_6 PFAM peptidase S9 prolyl oligopeptidase active site domain protein K01322,K01354 - 3.4.21.26,3.4.21.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 401.0
TLS2_k127_3509940_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 402.0
TLS2_k127_3509940_8 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 347.0
TLS2_k127_3509940_9 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 351.0
TLS2_k127_3549405_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 8.455e-211 669.0
TLS2_k127_3549405_1 Bacterial extracellular solute-binding protein K02027,K05813 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006897 603.0
TLS2_k127_3549405_10 Flagellar Motor Protein K02557 - - 0.000000000000000000000000000000005306 149.0
TLS2_k127_3549405_11 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000002683 101.0
TLS2_k127_3549405_12 EthD domain - - - 0.00000000001156 69.0
TLS2_k127_3549405_13 membrane K02451,K03832 - - 0.0000000001083 75.0
TLS2_k127_3549405_14 COG3839 ABC-type sugar transport systems, ATPase components K05816 - 3.6.3.20 0.0008996 43.0
TLS2_k127_3549405_2 Peptidoglycan-binding domain 1 protein K02450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 539.0
TLS2_k127_3549405_3 TRAP transporter, 4TM 12TM fusion protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 492.0
TLS2_k127_3549405_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K19837 - 3.5.1.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 476.0
TLS2_k127_3549405_5 COG3839 ABC-type sugar transport systems, ATPase components K05816 - 3.6.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 410.0
TLS2_k127_3549405_6 ABC-type sugar transport system, permease component K05815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006413 401.0
TLS2_k127_3549405_7 binding-protein-dependent transport systems inner membrane component K02025,K05814,K10118,K17242,K17245 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 403.0
TLS2_k127_3549405_8 Enoyl-CoA hydratase/isomerase K13766,K13779 - 4.2.1.18,4.2.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 318.0
TLS2_k127_3549405_9 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000001627 239.0
TLS2_k127_3554032_0 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 4.296e-201 639.0
TLS2_k127_3554032_1 NMT1/THI5 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008379 496.0
TLS2_k127_3554032_10 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000005405 188.0
TLS2_k127_3554032_11 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044421,GO:0046872,GO:0046914,GO:0046983,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 0.00000000000000000000000000000000000000000002547 167.0
TLS2_k127_3554032_12 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.0000000000000000000000000000000000000000001455 176.0
TLS2_k127_3554032_13 tRNA 3'-trailer cleavage K00784 - 3.1.26.11 0.000000000000000000000000000000000000000001146 169.0
TLS2_k127_3554032_14 PFAM AzlC - - - 0.000000000000000000000000000000001427 140.0
TLS2_k127_3554032_15 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.00000000000000000000000000000001129 132.0
TLS2_k127_3554032_16 Cupin domain - - - 0.0000000000000000001439 93.0
TLS2_k127_3554032_17 Helix-turn-helix domain - - - 0.0000000000000000007198 88.0
TLS2_k127_3554032_18 TonB C terminal K03832 - - 0.000007991 58.0
TLS2_k127_3554032_19 branched-chain amino acid - - - 0.0009112 51.0
TLS2_k127_3554032_2 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 351.0
TLS2_k127_3554032_3 COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 344.0
TLS2_k127_3554032_4 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007091 349.0
TLS2_k127_3554032_5 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 316.0
TLS2_k127_3554032_6 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008401 259.0
TLS2_k127_3554032_7 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000008423 235.0
TLS2_k127_3554032_8 dihydroorotate dehydrogenase activity K02823,K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000002013 213.0
TLS2_k127_3554032_9 MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000000000001929 194.0
TLS2_k127_371628_0 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 1.152e-265 836.0
TLS2_k127_371628_1 Protein of unknown function, DUF255 K06888 - - 1.236e-231 752.0
TLS2_k127_371628_10 endonuclease III K00558,K01962,K01963,K03575 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.37,2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000004861 277.0
TLS2_k127_371628_11 abc-type fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001159 259.0
TLS2_k127_371628_12 FAD dependent oxidoreductase K03153 - 1.4.3.19 0.000000000000000000000000000000000000000000000000000000000000000000000001644 265.0
TLS2_k127_371628_13 PFAM thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate - - - 0.000000000000000000000000000000000000000000000000000000000000000000001678 250.0
TLS2_k127_371628_14 TRAP transporter solute receptor TAXI family protein K07080 - - 0.000000000000000000000000000000000000000000000000000254 199.0
TLS2_k127_371628_15 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.000000000000000000000000000000000000000000000003 186.0
TLS2_k127_371628_16 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000000000009125 169.0
TLS2_k127_371628_17 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - - 0.00000000000000000000000000000000000000001243 169.0
TLS2_k127_371628_18 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000158 150.0
TLS2_k127_371628_19 Protein of unknown function (DUF4197) - - - 0.0000000000000000000000000000000000002721 161.0
TLS2_k127_371628_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 5.068e-201 637.0
TLS2_k127_371628_20 nUDIX hydrolase K03574,K03575 - 3.6.1.55 0.000000000000000000000000000003971 127.0
TLS2_k127_371628_21 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000006537 86.0
TLS2_k127_371628_22 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000944 85.0
TLS2_k127_371628_23 ThiS family - - - 0.000000001455 62.0
TLS2_k127_371628_3 Putative modulator of DNA gyrase K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 621.0
TLS2_k127_371628_4 transport system fused permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003399 607.0
TLS2_k127_371628_5 peptidase dimerisation domain protein K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 505.0
TLS2_k127_371628_6 Thiazole biosynthesis protein ThiG K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009588 375.0
TLS2_k127_371628_7 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 372.0
TLS2_k127_371628_8 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 302.0
TLS2_k127_371628_9 - K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007484 291.0
TLS2_k127_3746965_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 4.537e-277 862.0
TLS2_k127_3746965_1 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 509.0
TLS2_k127_3746965_10 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.8 0.0000000000000000000000000000000000000000000000000000002346 209.0
TLS2_k127_3746965_11 Ferredoxin - - - 0.00000000000000000000000000000000000000000006888 175.0
TLS2_k127_3746965_12 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.0000000000000000000000000000000000007985 146.0
TLS2_k127_3746965_13 Putative MetA-pathway of phenol degradation - - - 0.00000000000001093 87.0
TLS2_k127_3746965_14 Adenosylcobinamide amidohydrolase - - - 0.0000000004766 70.0
TLS2_k127_3746965_15 PFAM Sporulation domain protein - - - 0.000008046 56.0
TLS2_k127_3746965_16 energy transducer activity K03832 - - 0.00001392 58.0
TLS2_k127_3746965_2 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 421.0
TLS2_k127_3746965_3 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 349.0
TLS2_k127_3746965_4 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 353.0
TLS2_k127_3746965_5 TonB-dependent Receptor Plug Domain K16092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008808 351.0
TLS2_k127_3746965_6 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002253 252.0
TLS2_k127_3746965_7 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000001454 226.0
TLS2_k127_3746965_8 ABC transporter K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000002031 228.0
TLS2_k127_3746965_9 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000002598 216.0
TLS2_k127_3783262_0 DNA polymerase type-B family K02336 - 2.7.7.7 3.239e-203 664.0
TLS2_k127_3783262_1 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000003379 271.0
TLS2_k127_3783262_2 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000001775 227.0
TLS2_k127_3783262_3 serine-type endopeptidase activity K04691,K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000001887 188.0
TLS2_k127_3783262_4 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000014 155.0
TLS2_k127_3783262_5 PFAM RNP-1 like RNA-binding protein - - - 0.000000000000000000000001781 107.0
TLS2_k127_3783262_6 Virulence factor BrkB K07058 - - 0.0000000000022 79.0
TLS2_k127_3783262_7 Domain of unknown function (DUF309) K09763 - - 0.000000000004064 72.0
TLS2_k127_3783262_8 Thioredoxin - - - 0.000000004244 64.0
TLS2_k127_3790810_0 PFAM extracellular solute-binding protein, family 5 K02035,K13893 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 576.0
TLS2_k127_3790810_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00334,K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 447.0
TLS2_k127_3790810_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000000000003606 182.0
TLS2_k127_3790810_11 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000001855 165.0
TLS2_k127_3790810_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000104 162.0
TLS2_k127_3790810_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000000006919 121.0
TLS2_k127_3790810_14 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.00000000000000000000000000007393 121.0
TLS2_k127_3790810_15 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000002636 102.0
TLS2_k127_3790810_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009206 434.0
TLS2_k127_3790810_3 ATP synthesis coupled electron transport K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007737 436.0
TLS2_k127_3790810_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 430.0
TLS2_k127_3790810_5 PFAM Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008577 406.0
TLS2_k127_3790810_6 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000075 394.0
TLS2_k127_3790810_7 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 384.0
TLS2_k127_3790810_8 quinone binding K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003645 333.0
TLS2_k127_3790810_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000009645 242.0
TLS2_k127_3791914_0 MreB/Mbl protein K03569 GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 502.0
TLS2_k127_3791914_1 Penicillin-binding protein 2 K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009334 507.0
TLS2_k127_3791914_2 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000001232 241.0
TLS2_k127_3791914_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000326 195.0
TLS2_k127_3791914_4 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000003543 157.0
TLS2_k127_3791914_5 rod shape-determining protein MreD K03571 - - 0.00000000002045 71.0
TLS2_k127_3796150_0 Flavoprotein involved in K transport K03379,K21730 - 1.14.13.160,1.14.13.22 2.483e-281 872.0
TLS2_k127_3796150_1 Adenylate - - - 1.685e-231 758.0
TLS2_k127_3796150_10 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 357.0
TLS2_k127_3796150_11 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 308.0
TLS2_k127_3796150_12 Activator of Hsp90 ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001751 255.0
TLS2_k127_3796150_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000005344 237.0
TLS2_k127_3796150_14 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000000000005424 238.0
TLS2_k127_3796150_15 2OG-Fe(II) oxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000002133 230.0
TLS2_k127_3796150_16 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000001252 224.0
TLS2_k127_3796150_17 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000003135 230.0
TLS2_k127_3796150_18 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000006727 224.0
TLS2_k127_3796150_19 EVE domain - - - 0.00000000000000000000000000000000000000005353 158.0
TLS2_k127_3796150_2 RESPONSE REGULATOR receiver - - - 3.514e-199 627.0
TLS2_k127_3796150_20 - - - - 0.0000000000000000000000000000000000003599 158.0
TLS2_k127_3796150_21 - - - - 0.00000000000000000000000000000000004559 136.0
TLS2_k127_3796150_22 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000211 133.0
TLS2_k127_3796150_23 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000001507 95.0
TLS2_k127_3796150_24 - - - - 0.000000002533 60.0
TLS2_k127_3796150_25 Cupin - - - 0.000718 48.0
TLS2_k127_3796150_3 Flotillin - - - 2.026e-196 626.0
TLS2_k127_3796150_4 Kelch motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000949 555.0
TLS2_k127_3796150_5 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 563.0
TLS2_k127_3796150_6 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 503.0
TLS2_k127_3796150_7 Bacterial protein of unknown function (DUF899) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006857 438.0
TLS2_k127_3796150_8 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009443 440.0
TLS2_k127_3796150_9 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 391.0
TLS2_k127_3860439_0 Carboxyl transferase domain - - - 5.671e-206 655.0
TLS2_k127_3860439_1 response regulator K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 411.0
TLS2_k127_3860439_2 Esterase PHB depolymerase K03932 - - 0.000000000000000000000000000000000000000000000000000002884 203.0
TLS2_k127_3860439_3 PAS fold - - - 0.0000000000000000000000000000000000001952 148.0
TLS2_k127_3860439_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000003609 112.0
TLS2_k127_3860439_5 ECF sigma factor - - - 0.0000000000000000001736 98.0
TLS2_k127_3894747_0 succinate dehydrogenase K00239,K00278 - 1.3.5.1,1.3.5.4,1.4.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000303 587.0
TLS2_k127_3894747_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 443.0
TLS2_k127_3894747_2 TRAP transporter, 4TM 12TM fusion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 345.0
TLS2_k127_3894747_3 NMT1-like family K07080 - - 0.0000000000000000000000000286 121.0
TLS2_k127_3894747_4 Sulfur oxidation protein SoxY K17226 - - 0.0000000000000000003863 101.0
TLS2_k127_3894747_5 Sulphur oxidation protein SoxZ K17227 - - 0.0000000000001774 77.0
TLS2_k127_3894747_6 Alkyl hydroperoxide reductase - - - 0.0000000007024 63.0
TLS2_k127_3894747_7 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.00000002463 58.0
TLS2_k127_3897084_0 FtsX-like permease family K02004 - - 0.0 1070.0
TLS2_k127_3897084_1 TIGRFAM FeS assembly protein SufB K09014 - - 7.232e-252 784.0
TLS2_k127_3897084_10 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000002631 251.0
TLS2_k127_3897084_11 Domain of unknown function (DUF3482) - - - 0.000000000000000000000000000000000000000000000000000000000002315 229.0
TLS2_k127_3897084_12 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000000002079 218.0
TLS2_k127_3897084_13 Protein of unknown function (DUF2868) - - - 0.0000000000000000000000000000000000000000000000000000000001063 226.0
TLS2_k127_3897084_2 HlyD family secretion protein K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 445.0
TLS2_k127_3897084_3 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005762 400.0
TLS2_k127_3897084_4 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 394.0
TLS2_k127_3897084_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 327.0
TLS2_k127_3897084_6 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007201 311.0
TLS2_k127_3897084_7 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005464 291.0
TLS2_k127_3897084_8 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007464 299.0
TLS2_k127_3897084_9 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000958 283.0
TLS2_k127_3902281_0 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007556 599.0
TLS2_k127_3902281_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 554.0
TLS2_k127_3902281_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 527.0
TLS2_k127_3902281_3 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 396.0
TLS2_k127_3902281_4 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 314.0
TLS2_k127_3902281_5 NifU-like N terminal domain K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.0000000000000000000000000000000000000000000000000009472 202.0
TLS2_k127_3902281_6 Pfam:DUF59 K02612 - - 0.00000000000000000000000000000000001409 141.0
TLS2_k127_393857_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 6.826e-200 666.0
TLS2_k127_393857_1 Thiolase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 601.0
TLS2_k127_393857_10 PRC-barrel domain - - - 0.000000009597 63.0
TLS2_k127_393857_2 N-terminal domain of (some) glycogen debranching enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 612.0
TLS2_k127_393857_3 Thioesterase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 496.0
TLS2_k127_393857_4 Aminoglycoside phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005767 445.0
TLS2_k127_393857_5 Glycosyltransferase Family 4 K00713,K06338 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 394.0
TLS2_k127_393857_6 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 333.0
TLS2_k127_393857_7 COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs K03519,K11178 - 1.17.1.4,1.2.5.3 0.00000000000000000000000000000000000000000000000000000001717 211.0
TLS2_k127_393857_8 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000001096 196.0
TLS2_k127_393857_9 Luciferase-like monooxygenase - - - 0.00000000000000000000000001413 113.0
TLS2_k127_3974669_0 Peptidase family M1 domain K08776 - - 0.0 1052.0
TLS2_k127_3974669_1 - - - - 0.000000000000000000000000000000000000000000000000000009019 205.0
TLS2_k127_3974669_2 - - - - 0.000000000000000000000000000000000005541 145.0
TLS2_k127_3974669_3 VIT family - - - 0.0000000000000000000000006574 119.0
TLS2_k127_3974669_5 PFAM Rubrerythrin - - - 0.00000000000000000184 98.0
TLS2_k127_3974669_6 - - - - 0.000000007087 70.0
TLS2_k127_3982688_0 Hydantoinaseoxoprolinase domain protein K01469,K01473 - 3.5.2.14,3.5.2.9 8.181e-243 770.0
TLS2_k127_3982688_1 PFAM Hydantoinase B oxoprolinase K01469,K01474 - 3.5.2.14,3.5.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 619.0
TLS2_k127_3982688_10 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000235 245.0
TLS2_k127_3982688_11 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000002241 235.0
TLS2_k127_3982688_12 type IV pilus secretin PilQ K02666 - - 0.00000000000000000000000000000000000000000000000000000008351 222.0
TLS2_k127_3982688_13 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000001159 205.0
TLS2_k127_3982688_14 MOSC domain - - - 0.000000000000000000000000000000000000000000000000002183 192.0
TLS2_k127_3982688_15 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000006388 145.0
TLS2_k127_3982688_16 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000001429 137.0
TLS2_k127_3982688_17 Pilus assembly protein, PilO K02664 - - 0.00000000000000000138 94.0
TLS2_k127_3982688_18 Fimbrial assembly protein (PilN) K02663 - - 0.0000000000008202 79.0
TLS2_k127_3982688_19 Tetratricopeptide repeat - - - 0.000003414 59.0
TLS2_k127_3982688_2 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005936 544.0
TLS2_k127_3982688_3 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004026 475.0
TLS2_k127_3982688_4 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 428.0
TLS2_k127_3982688_5 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004742 420.0
TLS2_k127_3982688_6 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 323.0
TLS2_k127_3982688_7 PFAM ABC transporter related K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 340.0
TLS2_k127_3982688_8 ABC transporter, ATP-binding protein K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005508 295.0
TLS2_k127_3982688_9 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002677 259.0
TLS2_k127_4065744_0 aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 572.0
TLS2_k127_4065744_1 AAA ATPase K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006226 518.0
TLS2_k127_4065744_10 Outer membrane lipoprotein - - - 0.0000000000629 75.0
TLS2_k127_4065744_11 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000003628 68.0
TLS2_k127_4065744_12 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.000001106 63.0
TLS2_k127_4065744_13 HAD-hyrolase-like K22292 - 3.1.3.105 0.000003135 57.0
TLS2_k127_4065744_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 383.0
TLS2_k127_4065744_3 Glycosyltransferase family 28 N-terminal domain K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004432 333.0
TLS2_k127_4065744_4 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively K04099,K04101 - 1.13.11.57,1.13.11.8 0.000000000000000000000000000000000000000000000000000000002086 212.0
TLS2_k127_4065744_5 endonuclease III K07457 - - 0.00000000000000000000000000000000000000000000000000000001218 210.0
TLS2_k127_4065744_6 - - - - 0.0000000000000000005219 91.0
TLS2_k127_4065744_7 Maf-like protein K06287 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000002466 84.0
TLS2_k127_4065744_8 Belongs to the ClpA ClpB family - - - 0.0000000000000002588 81.0
TLS2_k127_4065744_9 Nitrate ABC transporter substrate-binding protein K02051 - - 0.0000000000001372 82.0
TLS2_k127_4095284_0 helicase activity - - - 1.269e-317 992.0
TLS2_k127_4095284_1 Adenylate and Guanylate cyclase catalytic domain - - - 4.422e-240 781.0
TLS2_k127_4095284_10 PFAM Haloacid dehalogenase domain protein hydrolase K01560,K07025 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000001447 260.0
TLS2_k127_4095284_11 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000004285 245.0
TLS2_k127_4095284_12 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000001929 246.0
TLS2_k127_4095284_13 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000007719 229.0
TLS2_k127_4095284_14 Thioesterase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000001102 216.0
TLS2_k127_4095284_15 Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells K03649 - 3.2.2.28 0.000000000000000000000000000000000000000000000000001574 188.0
TLS2_k127_4095284_16 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000007938 150.0
TLS2_k127_4095284_17 COG0477 Permeases of the major facilitator superfamily - - - 0.0000001123 62.0
TLS2_k127_4095284_2 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 552.0
TLS2_k127_4095284_3 N-methylhydantoinase B acetone carboxylase alpha subunit K01474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0017168,GO:0034641,GO:0043603,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071704,GO:1901564 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004686 482.0
TLS2_k127_4095284_4 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 429.0
TLS2_k127_4095284_5 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 350.0
TLS2_k127_4095284_6 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 366.0
TLS2_k127_4095284_7 NAD(P)-binding Rossmann-like domain K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007296 310.0
TLS2_k127_4095284_8 Serine hydrolase (FSH1) K06999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003406 283.0
TLS2_k127_4095284_9 PFAM sigma-54 factor interaction domain-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002882 292.0
TLS2_k127_4124200_0 PFAM Hydantoinase B oxoprolinase - - - 4.881e-196 635.0
TLS2_k127_4124200_1 Hydantoinase/oxoprolinase - - - 1.696e-194 628.0
TLS2_k127_4124200_10 D-amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002818 260.0
TLS2_k127_4124200_11 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004819 252.0
TLS2_k127_4124200_12 CO dehydrogenase flavoprotein C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000009828 233.0
TLS2_k127_4124200_13 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000000000000003453 170.0
TLS2_k127_4124200_14 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518,K13483,K20446 - 1.17.1.5,1.2.5.3 0.000000000000000000000000000000000000000000001138 184.0
TLS2_k127_4124200_15 transport system periplasmic component - - - 0.000000000000000000000000000000000000000000001463 180.0
TLS2_k127_4124200_16 UTRA - - - 0.0000000000000000000000000000000001149 145.0
TLS2_k127_4124200_17 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000002235 135.0
TLS2_k127_4124200_18 transcriptional regulator RpiR family - - - 0.00000000000000000000000000000001324 139.0
TLS2_k127_4124200_19 COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.00000000000000000000000000000002652 132.0
TLS2_k127_4124200_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 604.0
TLS2_k127_4124200_20 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.000000000000000000000000007297 123.0
TLS2_k127_4124200_21 oxidoreductase activity, acting on CH-OH group of donors K09386 - - 0.0000000000000000000001342 110.0
TLS2_k127_4124200_22 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.0002157 50.0
TLS2_k127_4124200_3 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007876 524.0
TLS2_k127_4124200_4 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 444.0
TLS2_k127_4124200_5 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 467.0
TLS2_k127_4124200_6 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003749 393.0
TLS2_k127_4124200_7 PFAM short-chain dehydrogenase reductase SDR K00023,K00059 - 1.1.1.100,1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 346.0
TLS2_k127_4124200_8 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008536 327.0
TLS2_k127_4124200_9 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 315.0
TLS2_k127_4141235_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006769 524.0
TLS2_k127_4141235_1 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004454 397.0
TLS2_k127_4141235_10 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000345 243.0
TLS2_k127_4141235_11 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000002547 190.0
TLS2_k127_4141235_12 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000001667 181.0
TLS2_k127_4141235_13 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000008695 176.0
TLS2_k127_4141235_14 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000009934 138.0
TLS2_k127_4141235_15 PFAM ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000002768 142.0
TLS2_k127_4141235_16 Belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.000000000000000000000000003596 126.0
TLS2_k127_4141235_17 Belongs to the bacterial ribosomal protein bL36 family K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000457 68.0
TLS2_k127_4141235_2 Metallopeptidase family M24 K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 314.0
TLS2_k127_4141235_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009596 276.0
TLS2_k127_4141235_4 PFAM glutamine amidotransferase class-I K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000004498 266.0
TLS2_k127_4141235_5 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001018 264.0
TLS2_k127_4141235_6 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001557 271.0
TLS2_k127_4141235_7 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000004344 256.0
TLS2_k127_4141235_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000004931 254.0
TLS2_k127_4141235_9 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000006289 262.0
TLS2_k127_4196690_0 dipeptide transport K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007378 458.0
TLS2_k127_4196690_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 435.0
TLS2_k127_4196690_10 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.0000000000000000000000000000000000000000000000002035 185.0
TLS2_k127_4196690_11 MaoC like domain - - - 0.0000000000000000000000000000000000006776 154.0
TLS2_k127_4196690_12 membrane - - - 0.0000000000000000000000009645 114.0
TLS2_k127_4196690_13 Histidine kinase - - - 0.00001211 58.0
TLS2_k127_4196690_2 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 434.0
TLS2_k127_4196690_3 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 417.0
TLS2_k127_4196690_4 Alcohol dehydrogenase zinc-binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 353.0
TLS2_k127_4196690_5 Phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 338.0
TLS2_k127_4196690_6 Putative serine dehydratase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 317.0
TLS2_k127_4196690_7 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009136 257.0
TLS2_k127_4196690_8 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000002113 208.0
TLS2_k127_4196690_9 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000003156 186.0
TLS2_k127_4230529_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 6.488e-291 910.0
TLS2_k127_4230529_1 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004858 617.0
TLS2_k127_4230529_10 Receptor family ligand binding region family protein 22 K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000001 255.0
TLS2_k127_4230529_11 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000001106 247.0
TLS2_k127_4230529_12 4Fe-4S single cluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000853 220.0
TLS2_k127_4230529_13 transferase activity, transferring glycosyl groups K20742 - 3.4.14.13 0.000000000000000000000000000000000000000000000000000000003643 221.0
TLS2_k127_4230529_14 ATP-grasp - - - 0.000000000000000000000000000000000000000000000000000144 201.0
TLS2_k127_4230529_15 PFAM Integrase - - - 0.000000000000000000000000009049 111.0
TLS2_k127_4230529_16 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K11688 - - 0.0000000000000001176 94.0
TLS2_k127_4230529_18 Protein of unknown function (DUF1007) - - - 0.0000001368 65.0
TLS2_k127_4230529_2 PFAM alanine racemase domain protein K20757 - 4.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 374.0
TLS2_k127_4230529_3 COG1335 Amidases related to nicotinamidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 329.0
TLS2_k127_4230529_4 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 326.0
TLS2_k127_4230529_5 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001875 278.0
TLS2_k127_4230529_6 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003289 271.0
TLS2_k127_4230529_7 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007932 258.0
TLS2_k127_4230529_8 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008688 255.0
TLS2_k127_4230529_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002603 252.0
TLS2_k127_4241010_0 Fe-S type, tartrate fumarate subfamily, alpha subunit K03779 - 4.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 466.0
TLS2_k127_4241010_1 alpha/beta hydrolase fold K01563,K22318 - 3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 421.0
TLS2_k127_4241010_11 - - - - 0.00000000000879 76.0
TLS2_k127_4241010_12 Redoxin - - - 0.000001241 61.0
TLS2_k127_4241010_2 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 389.0
TLS2_k127_4241010_3 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 365.0
TLS2_k127_4241010_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005324 333.0
TLS2_k127_4241010_5 COG1838 Tartrate dehydratase beta subunit Fumarate hydratase class I, C-terminal domain K03780 - 4.2.1.32 0.000000000000000000000000000000000000000000000000000000000000000000000001888 265.0
TLS2_k127_4241010_6 intermembrane phospholipid transfer K07323 - - 0.000000000000000000000000000000000000000000009471 173.0
TLS2_k127_4241010_7 Redoxin - - - 0.000000000000000000000000000001307 123.0
TLS2_k127_4241010_8 PFAM AMP-dependent synthetase and ligase K00666 - - 0.000000000000000000000000000001427 132.0
TLS2_k127_4241010_9 Belongs to the universal stress protein A family - - - 0.00000000000008987 74.0
TLS2_k127_4277665_0 Adenylate and Guanylate cyclase catalytic domain - - - 3.093e-288 922.0
TLS2_k127_4277665_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004043 335.0
TLS2_k127_4277665_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000008137 250.0
TLS2_k127_4277665_3 - - - - 0.0000000000000000000000000000002245 134.0
TLS2_k127_4277665_4 Domain of unknown function (DUF5009) - - - 0.000000000000005883 78.0
TLS2_k127_4277665_5 Dienelactone hydrolase family - - - 0.0000000000001453 82.0
TLS2_k127_4277665_6 PFAM GYD family protein - - - 0.0005772 48.0
TLS2_k127_4293633_0 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007157 446.0
TLS2_k127_4293633_1 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002908 431.0
TLS2_k127_4293633_10 serine-type endopeptidase activity K08372 - - 0.000000000000000000000000000000000000000000000000000000000000000005137 241.0
TLS2_k127_4293633_11 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.0000000000000000000000000000000000000000000000000000000000004562 221.0
TLS2_k127_4293633_12 3-hydroxyanthranilate 3,4-dioxygenase activity - - - 0.00000000000000000000000000000000000001883 147.0
TLS2_k127_4293633_13 COG2076 Membrane transporters of cations and cationic drugs K11741 - - 0.0000000000000000000000000000000004045 143.0
TLS2_k127_4293633_14 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000000000000000000000000000006663 126.0
TLS2_k127_4293633_15 DNA polymerase III K02342 - 2.7.7.7 0.000000000000000000000000000009584 129.0
TLS2_k127_4293633_16 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000003119 71.0
TLS2_k127_4293633_17 Domain of unknown function (DUF4328) - - - 0.00000000004139 76.0
TLS2_k127_4293633_18 - - - - 0.000001104 61.0
TLS2_k127_4293633_19 AsmA-like C-terminal region K07289 - - 0.000007276 59.0
TLS2_k127_4293633_2 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 444.0
TLS2_k127_4293633_3 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 404.0
TLS2_k127_4293633_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 389.0
TLS2_k127_4293633_5 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 376.0
TLS2_k127_4293633_6 CBS domain containing protein K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 342.0
TLS2_k127_4293633_7 Peptidase M16 K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000114 303.0
TLS2_k127_4293633_8 deaminated base DNA N-glycosylase activity K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002162 285.0
TLS2_k127_4293633_9 Asparaginase K13051 - 3.4.19.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000007812 272.0
TLS2_k127_4331130_0 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 595.0
TLS2_k127_4331130_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000506 562.0
TLS2_k127_4331130_10 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000009789 161.0
TLS2_k127_4331130_11 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000001377 171.0
TLS2_k127_4331130_12 Glycoprotease family K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.000000000000000000000000000000000000000005977 177.0
TLS2_k127_4331130_13 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000000000000000000000000000000361 141.0
TLS2_k127_4331130_14 of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000001147 127.0
TLS2_k127_4331130_15 COG3909 Cytochrome c556 - - - 0.00001163 54.0
TLS2_k127_4331130_16 ArgK protein K07588 - - 0.0007843 43.0
TLS2_k127_4331130_2 Beta-Casp domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006143 467.0
TLS2_k127_4331130_3 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 378.0
TLS2_k127_4331130_4 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000002265 228.0
TLS2_k127_4331130_5 - - - - 0.000000000000000000000000000000000000000000000000000000000003695 217.0
TLS2_k127_4331130_6 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000001303 225.0
TLS2_k127_4331130_7 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000002423 192.0
TLS2_k127_4331130_8 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000005902 192.0
TLS2_k127_4331130_9 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000003952 166.0
TLS2_k127_4364055_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 8.51e-275 869.0
TLS2_k127_4364055_1 chelatase, subunit ChlI K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 481.0
TLS2_k127_4364055_10 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000002724 126.0
TLS2_k127_4364055_11 Transcriptional regulator, MerR family K13640 GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000002802 119.0
TLS2_k127_4364055_12 ATPases associated with a variety of cellular activities K01996 - - 0.000000005119 57.0
TLS2_k127_4364055_2 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 432.0
TLS2_k127_4364055_3 Bacterial extracellular solute-binding proteins, family 5 Middle K13893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008132 446.0
TLS2_k127_4364055_4 response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 432.0
TLS2_k127_4364055_5 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000008474 245.0
TLS2_k127_4364055_6 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000001199 181.0
TLS2_k127_4364055_7 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000258 183.0
TLS2_k127_4364055_8 PFAM Lytic transglycosylase catalytic K08309 - - 0.000000000000000000000000000000000000000000000005123 180.0
TLS2_k127_4364055_9 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000003648 139.0
TLS2_k127_4401426_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298,K15408 - 1.10.3.10,1.9.3.1 3.339e-228 730.0
TLS2_k127_4401426_1 Cytochrome c K00412 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 455.0
TLS2_k127_4401426_2 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K17223 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003709 286.0
TLS2_k127_4401426_3 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.000000000000000000000000000000000000000000000000000000000001018 228.0
TLS2_k127_4401426_4 PFAM Rieske 2Fe-2S domain protein - - - 0.00000000000000000000000000000000000000000000000000006299 197.0
TLS2_k127_4401426_5 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.00000000000000000000000000000000000000000000000004858 194.0
TLS2_k127_4401426_6 Cytochrome c oxidase subunit III - - - 0.0000000000000000000000000000000000000000000000001328 189.0
TLS2_k127_4401426_7 Trypsin - - - 0.00000000000000000001951 107.0
TLS2_k127_4401426_8 SNARE associated Golgi protein K03975 - - 0.0000000000000007712 92.0
TLS2_k127_4401426_9 Crp Fnr family K10914 GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - 0.00000000003904 76.0
TLS2_k127_440746_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 590.0
TLS2_k127_440746_1 Belongs to the GPI family K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 493.0
TLS2_k127_440746_2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 486.0
TLS2_k127_440746_3 D-gluconate metabolic process K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 404.0
TLS2_k127_440746_4 KR domain K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009771 352.0
TLS2_k127_440746_5 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000001034 231.0
TLS2_k127_440746_6 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000002403 153.0
TLS2_k127_440746_7 - - - - 0.000005866 54.0
TLS2_k127_4452389_0 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 3.393e-213 680.0
TLS2_k127_4452389_1 Myo-inositol-1-phosphate synthase, GAPDH domain protein K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 558.0
TLS2_k127_4452389_10 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002286 293.0
TLS2_k127_4452389_11 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000001005 257.0
TLS2_k127_4452389_12 Belongs to the malate synthase family K01638 - 2.3.3.9 0.0000000000000000000000000000000000000000000000000000000000000004722 241.0
TLS2_k127_4452389_13 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.000000000000000000000000000000000000000000000000000003584 209.0
TLS2_k127_4452389_14 intermembrane phospholipid transfer K07323 - - 0.0000000000000000000000000000000000000000000000002122 188.0
TLS2_k127_4452389_15 Nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000000006896 189.0
TLS2_k127_4452389_16 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000002528 177.0
TLS2_k127_4452389_17 - - - - 0.000000000000003358 89.0
TLS2_k127_4452389_18 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.0000001093 65.0
TLS2_k127_4452389_19 - - - - 0.0000004748 56.0
TLS2_k127_4452389_2 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 526.0
TLS2_k127_4452389_20 Phosphorylase superfamily K01243 - 3.2.2.9 0.000001595 58.0
TLS2_k127_4452389_3 MMPL family K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 459.0
TLS2_k127_4452389_4 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008691 394.0
TLS2_k127_4452389_5 NmrA-like family K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 376.0
TLS2_k127_4452389_6 ABC-type transport system involved in resistance to organic solvents permease component K02066 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 312.0
TLS2_k127_4452389_7 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 300.0
TLS2_k127_4452389_8 2OG-Fe(II) oxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001129 285.0
TLS2_k127_4452389_9 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004047 292.0
TLS2_k127_4482060_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 402.0
TLS2_k127_4482060_1 response - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 335.0
TLS2_k127_4482060_2 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007991 301.0
TLS2_k127_4482060_3 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000003592 231.0
TLS2_k127_4482060_4 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000003129 174.0
TLS2_k127_4482060_5 diguanylate cyclase - - - 0.000000000000000000000000000000000000001934 159.0
TLS2_k127_4482060_6 sulfur carrier activity - - - 0.000000000000000000002144 95.0
TLS2_k127_4482060_7 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000001358 78.0
TLS2_k127_4613117_0 Belongs to the glycosyl hydrolase 57 family K16149 - 2.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 531.0
TLS2_k127_4613117_1 PFAM Glycoside hydrolase family 65, central catalytic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 549.0
TLS2_k127_4613117_2 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 - 2.4.1.321 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005568 439.0
TLS2_k127_4613117_3 FAD-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008198 404.0
TLS2_k127_4613117_4 Peptidase family M48 - - - 0.0000000000000000000158 96.0
TLS2_k127_4613117_5 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000003628 68.0
TLS2_k127_4613117_6 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000009028 64.0
TLS2_k127_4633785_0 Putative modulator of DNA gyrase K03592 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 424.0
TLS2_k127_4633785_1 Putative modulator of DNA gyrase K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 370.0
TLS2_k127_4633785_2 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000002815 191.0
TLS2_k127_4633785_3 PAS fold - - - 0.00000000000000000000000000000000000000000000000002306 195.0
TLS2_k127_4633785_4 Serine aminopeptidase, S33 K06889,K07397 - - 0.0000000000000000000000000000000005229 143.0
TLS2_k127_4636646_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates - - - 2.912e-254 809.0
TLS2_k127_4636646_1 PFAM type II secretion system protein E K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 549.0
TLS2_k127_4636646_10 intermembrane phospholipid transfer K07323 - - 0.000000000000000000000000000000000000000000000000506 183.0
TLS2_k127_4636646_11 - - - - 0.0000000000000000000000000000000000000000000001924 177.0
TLS2_k127_4636646_12 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000001618 179.0
TLS2_k127_4636646_13 Histidine kinase - - - 0.000000000000000000000000000000001705 134.0
TLS2_k127_4636646_14 zinc-ribbon domain - - - 0.00000000000000000000000001275 116.0
TLS2_k127_4636646_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000004903 106.0
TLS2_k127_4636646_16 - - - - 0.000000000000000000006592 104.0
TLS2_k127_4636646_17 - - - - 0.00000000000000000007672 94.0
TLS2_k127_4636646_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000007992 100.0
TLS2_k127_4636646_19 - K18475 - - 0.000000000000000002131 99.0
TLS2_k127_4636646_2 Type IV secretion-system coupling protein DNA-binding domain K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 543.0
TLS2_k127_4636646_20 Clostridial hydrophobic W - - - 0.00000000000000005489 95.0
TLS2_k127_4636646_21 Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000001302 87.0
TLS2_k127_4636646_22 - - - - 0.0000000001555 70.0
TLS2_k127_4636646_3 dna ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 420.0
TLS2_k127_4636646_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 347.0
TLS2_k127_4636646_5 metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 344.0
TLS2_k127_4636646_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000829 327.0
TLS2_k127_4636646_7 Protein involved in cellulose biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 306.0
TLS2_k127_4636646_8 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 318.0
TLS2_k127_4636646_9 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000000006298 184.0
TLS2_k127_4636689_0 Calcineurin-like phosphoesterase K01028,K07098 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 515.0
TLS2_k127_4636689_1 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 443.0
TLS2_k127_4636689_2 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 423.0
TLS2_k127_4636689_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 390.0
TLS2_k127_4636689_4 PFAM Pyridine nucleotide-disulphide oxidoreductase, FAD NAD(P)-binding domain, pyridine nucleotide-disulfide oxidoreductase dimerization region, FAD-dependent pyridine nucleotide-disulfide oxidoreductase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 361.0
TLS2_k127_4636689_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008404 352.0
TLS2_k127_4636689_6 SWIM zinc finger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006295 247.0
TLS2_k127_4636689_7 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.0000000000000000000000000000000000000000000008681 171.0
TLS2_k127_4636689_8 40-residue YVTN family beta-propeller repeat - - - 0.00000000000000000000000000000000000000000001339 175.0
TLS2_k127_4636689_9 40-residue YVTN family beta-propeller - - - 0.00000000000000000000000000000000000000000004438 178.0
TLS2_k127_4678509_0 Penicillin amidase K07116 - 3.5.1.97 2.368e-211 684.0
TLS2_k127_4678509_1 DNA topoisomerase VI subunit A K03166 - 5.99.1.3 6.223e-210 655.0
TLS2_k127_4678509_2 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009644 350.0
TLS2_k127_4678509_3 DNA topoisomerase II activity K03167 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001408 276.0
TLS2_k127_4678509_4 - - - - 0.000000000000000000000000000000000000000000000000002613 192.0
TLS2_k127_4678509_5 Domain of unknown function (DUF1998) - - - 0.00000000000000000000000000000000000000000007788 175.0
TLS2_k127_4678509_6 Domain of unknown function (DUF4172) - - - 0.00000000000002488 79.0
TLS2_k127_4678509_7 OsmC-like protein K06889,K07397 - - 0.0000008195 57.0
TLS2_k127_4678509_8 Redoxin K03564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 0.0006879 45.0
TLS2_k127_4679309_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 5.386e-319 998.0
TLS2_k127_4679309_1 PFAM 4Fe-4S binding domain - - - 3.356e-219 687.0
TLS2_k127_4679309_10 - - - - 0.0000000000000000000000000000000000000000000000000007751 190.0
TLS2_k127_4679309_11 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000007353 167.0
TLS2_k127_4679309_12 O-methyltransferase - - - 0.0000000000000000000000000000000000000000002371 169.0
TLS2_k127_4679309_13 COGs COG4636 conserved - - - 0.00000000000000000000000000000000000000001991 159.0
TLS2_k127_4679309_14 SnoaL-like domain K06893 - - 0.0000000000000000000000000000000000000005926 154.0
TLS2_k127_4679309_15 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000007147 90.0
TLS2_k127_4679309_16 - - - - 0.0000000000000006654 79.0
TLS2_k127_4679309_17 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000001052 73.0
TLS2_k127_4679309_18 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 0.000000000237 66.0
TLS2_k127_4679309_19 Major Facilitator Superfamily - - - 0.000000134 56.0
TLS2_k127_4679309_2 PFAM FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 498.0
TLS2_k127_4679309_20 - - - - 0.0000004909 56.0
TLS2_k127_4679309_3 aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008643 437.0
TLS2_k127_4679309_4 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006462 397.0
TLS2_k127_4679309_5 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004777 393.0
TLS2_k127_4679309_7 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain K17736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 346.0
TLS2_k127_4679309_8 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003009 281.0
TLS2_k127_4679309_9 Peptidase dimerisation domain K01436 - - 0.0000000000000000000000000000000000000000000000000005039 198.0
TLS2_k127_4693753_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 492.0
TLS2_k127_4693753_1 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 430.0
TLS2_k127_4693753_2 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000009289 245.0
TLS2_k127_4693753_3 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000008596 171.0
TLS2_k127_4693753_4 PFAM Cyclic nucleotide-binding K10914 GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - 0.0000000000000000000003547 102.0
TLS2_k127_4693753_5 Peptidase M50 K16922 - - 0.0000000000000000000008747 110.0
TLS2_k127_4693753_6 PFAM response regulator receiver - - - 0.0004188 49.0
TLS2_k127_4699797_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370,K07306,K17050 - 1.7.5.1,1.8.5.3 0.0 1687.0
TLS2_k127_4699797_1 nitrate reductase beta subunit K00371,K17051 - 1.7.5.1 2.047e-204 640.0
TLS2_k127_4699797_10 NADH dehydrogenase K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 383.0
TLS2_k127_4699797_11 Phenazine biosynthesis-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 344.0
TLS2_k127_4699797_12 Trypsin-like serine protease K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009614 304.0
TLS2_k127_4699797_13 chaperone-mediated protein complex assembly - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000463 313.0
TLS2_k127_4699797_14 Belongs to the heme-copper respiratory oxidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001058 276.0
TLS2_k127_4699797_15 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001829 269.0
TLS2_k127_4699797_16 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006278 246.0
TLS2_k127_4699797_17 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281,K12132 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0030145,GO:0034641,GO:0034654,GO:0043094,GO:0043167,GO:0043169,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.11.1,3.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000005973 243.0
TLS2_k127_4699797_18 transferase activity, transferring glycosyl groups K00754 - - 0.0000000000000000000000000000000000000000000000000000000000000001385 240.0
TLS2_k127_4699797_19 FIST C domain - GO:0008150,GO:0040007 - 0.000000000000000000000000000000000000000000000000000000000007655 222.0
TLS2_k127_4699797_2 Proton-conducting membrane transporter K12137,K15828 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005651 586.0
TLS2_k127_4699797_20 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000002748 212.0
TLS2_k127_4699797_21 HAMP domain K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000003064 210.0
TLS2_k127_4699797_22 FmdE, Molybdenum formylmethanofuran dehydrogenase operon K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000000004713 179.0
TLS2_k127_4699797_23 Domain of unknown function (DUF1858) - - - 0.000000000000000000000000000000000000000000000257 181.0
TLS2_k127_4699797_24 Radical SAM - - - 0.000000000000000000000000000000000000000001455 177.0
TLS2_k127_4699797_25 SCO1/SenC K07152,K08976 - - 0.0000000000000000000000000000000000001896 155.0
TLS2_k127_4699797_26 helix_turn_helix, cAMP Regulatory protein K21564 - - 0.0000000000000000000000000000000001873 142.0
TLS2_k127_4699797_27 Hydrogenase 4 membrane K12140 GO:0008150,GO:0040007 - 0.0000000000000000000000000000000005447 151.0
TLS2_k127_4699797_28 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure - - - 0.0000000000000000000000000001558 118.0
TLS2_k127_4699797_29 Uncharacterized conserved protein (DUF2249) - - - 0.000000000000000000000000003538 119.0
TLS2_k127_4699797_3 NADH dehydrogenase (ubiquinone) activity K14089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 557.0
TLS2_k127_4699797_30 SNARE associated Golgi protein - - - 0.00000000000000000000001242 108.0
TLS2_k127_4699797_31 RNA recognition motif - - - 0.00000000000000000000001696 105.0
TLS2_k127_4699797_32 Gas vesicle protein K - - - 0.0000000000000000000002271 106.0
TLS2_k127_4699797_33 Domain of unknown function (DUF4149) - - - 0.00000000000000000001258 96.0
TLS2_k127_4699797_34 chaperone-mediated protein complex assembly - - - 0.0000000000000001725 93.0
TLS2_k127_4699797_35 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.000000000000005388 85.0
TLS2_k127_4699797_36 His Kinase A (phosphoacceptor) domain - - - 0.00009981 49.0
TLS2_k127_4699797_37 Glycosyl transferase 4-like domain - - - 0.000107 49.0
TLS2_k127_4699797_4 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002922 535.0
TLS2_k127_4699797_5 Epoxide hydrolase N terminus K01253 - 3.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 501.0
TLS2_k127_4699797_6 PFAM Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 459.0
TLS2_k127_4699797_7 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 449.0
TLS2_k127_4699797_8 Proton-conducting membrane transporter K12141 GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 451.0
TLS2_k127_4699797_9 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 429.0
TLS2_k127_4725557_0 Hydantoinase/oxoprolinase N-terminal region K01469,K01473 - 3.5.2.14,3.5.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 560.0
TLS2_k127_4725557_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 541.0
TLS2_k127_4725557_10 C4-type zinc ribbon domain K07164,K22391 - 3.5.4.16 0.00000000000000000000000000000217 129.0
TLS2_k127_4725557_11 - - - - 0.00000000000002333 76.0
TLS2_k127_4725557_2 two-component system sensor protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 420.0
TLS2_k127_4725557_3 FR47-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006455 258.0
TLS2_k127_4725557_4 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000006098 196.0
TLS2_k127_4725557_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000001282 185.0
TLS2_k127_4725557_6 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000000000000000000000000000000000000000001875 202.0
TLS2_k127_4725557_7 Domain of unknown function (DUF1835) - - - 0.000000000000000000000000000000000000000000000119 185.0
TLS2_k127_4725557_8 Sigma-54 interaction domain - GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000004455 178.0
TLS2_k127_4725557_9 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000001922 166.0
TLS2_k127_4735674_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1248.0
TLS2_k127_4735674_1 Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 494.0
TLS2_k127_4735674_10 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000004745 277.0
TLS2_k127_4735674_11 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000001815 210.0
TLS2_k127_4735674_12 Aminoacyl-tRNA editing domain - - - 0.000000000000000000000000000000000000000000000000002643 190.0
TLS2_k127_4735674_13 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000004815 186.0
TLS2_k127_4735674_14 PFAM PfkB domain protein - - - 0.0000000000000000000000000000000000000000000000001144 188.0
TLS2_k127_4735674_15 peptidase m48, ste24p - - - 0.00000000000000000000000000000000000000000009311 178.0
TLS2_k127_4735674_16 DinB superfamily - - - 0.00000000000000000000000000000000002003 143.0
TLS2_k127_4735674_17 COG2346, Truncated hemoglobins K06886 - - 0.000000000000000000000000000000000149 137.0
TLS2_k127_4735674_18 Thioesterase superfamily - - - 0.0000000000000000000000000000000001608 138.0
TLS2_k127_4735674_19 Periplasmic binding protein - - - 0.0000000000000000000000000000000009364 132.0
TLS2_k127_4735674_2 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 426.0
TLS2_k127_4735674_20 Cyclophilin-like K09143 - - 0.000000000000000000000000000000001268 134.0
TLS2_k127_4735674_21 - - - - 0.00000000000000000000000000004825 128.0
TLS2_k127_4735674_22 - - - - 0.000000000000000000000000001439 131.0
TLS2_k127_4735674_23 Pfam GAF - - - 0.0000000000000000000008886 114.0
TLS2_k127_4735674_24 BON domain K04065 - - 0.0004734 47.0
TLS2_k127_4735674_3 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006516 416.0
TLS2_k127_4735674_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 451.0
TLS2_k127_4735674_5 acyl-CoA dehydrogenase K04117 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000684 404.0
TLS2_k127_4735674_6 PFAM AMP-dependent synthetase and ligase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 387.0
TLS2_k127_4735674_7 Acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003808 314.0
TLS2_k127_4735674_8 PA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007759 285.0
TLS2_k127_4735674_9 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001898 270.0
TLS2_k127_4749821_0 serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 4.55e-256 797.0
TLS2_k127_4749821_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 576.0
TLS2_k127_4749821_10 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000008724 145.0
TLS2_k127_4749821_11 Protein of unknown function (DUF1232) - - - 0.00000000000000509 88.0
TLS2_k127_4749821_2 PFAM transglutaminase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 466.0
TLS2_k127_4749821_3 PFAM Coenzyme A transferase K01039 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 458.0
TLS2_k127_4749821_4 Bacterial regulatory helix-turn-helix protein, lysR family K04761 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 340.0
TLS2_k127_4749821_5 DUF35 OB-fold domain, acyl-CoA-associated K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003746 312.0
TLS2_k127_4749821_6 LAO AO transport system ATPase K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002 278.0
TLS2_k127_4749821_7 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000652 158.0
TLS2_k127_4749821_8 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000002665 145.0
TLS2_k127_4749821_9 Ankyrin repeat K06867 - - 0.000000000000000000000000000000000008546 154.0
TLS2_k127_4772944_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 522.0
TLS2_k127_4772944_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 409.0
TLS2_k127_4772944_10 Belongs to the UPF0235 family K09131 - - 0.0000000000008904 74.0
TLS2_k127_4772944_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 381.0
TLS2_k127_4772944_3 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001957 284.0
TLS2_k127_4772944_4 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000000006627 224.0
TLS2_k127_4772944_5 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0005488,GO:0005507,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.00000000000000000000000000000000004475 146.0
TLS2_k127_4772944_6 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain K00075 - 1.3.1.98 0.000000000000000000000000008755 113.0
TLS2_k127_4772944_7 YGGT family K02221 - - 0.0000000000000000000000001563 120.0
TLS2_k127_4772944_8 PFAM DivIVA family protein K04074 - - 0.000000000000000000001499 105.0
TLS2_k127_4772944_9 Cell division protein FtsQ K03589 - - 0.00000000000000000001296 102.0
TLS2_k127_4774275_0 ABC transporter transmembrane region K06147,K18890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006863 542.0
TLS2_k127_4774275_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 433.0
TLS2_k127_4774275_10 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000001551 263.0
TLS2_k127_4774275_11 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000006813 243.0
TLS2_k127_4774275_12 Belongs to the UPF0282 family K07022 - - 0.00000000000000000000000000000000000000000000000004793 190.0
TLS2_k127_4774275_13 P-aminobenzoate N-oxygenase AurF - - - 0.0000000000000000000000000000000000000000000000009907 186.0
TLS2_k127_4774275_14 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.000000000000000000000000000000002914 134.0
TLS2_k127_4774275_15 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000002278 126.0
TLS2_k127_4774275_16 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.0000000000000000000000000004343 119.0
TLS2_k127_4774275_17 Redoxin - - - 0.00000000000000000006836 92.0
TLS2_k127_4774275_18 methylated DNA-protein cysteine methyltransferase K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 - 0.00000000000000007324 92.0
TLS2_k127_4774275_19 F420-dependent oxidoreductase K04091 - 1.14.14.5 0.0000000000000001442 93.0
TLS2_k127_4774275_2 Acetolactate synthase K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 407.0
TLS2_k127_4774275_20 Tetratricopeptide repeat - - - 0.0000000000000002525 88.0
TLS2_k127_4774275_21 Protein conserved in bacteria K09986 - - 0.00000000000001648 81.0
TLS2_k127_4774275_22 Redoxin - - - 0.0000000001189 73.0
TLS2_k127_4774275_3 ABC transporter transmembrane region K06147,K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 411.0
TLS2_k127_4774275_4 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 363.0
TLS2_k127_4774275_5 transport protein CorA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000543 302.0
TLS2_k127_4774275_6 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009872 305.0
TLS2_k127_4774275_7 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 288.0
TLS2_k127_4774275_8 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001765 272.0
TLS2_k127_4774275_9 Inositol monophosphatase K01082,K01092 GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000002466 260.0
TLS2_k127_4809664_0 Phosphopantetheine attachment site - - - 2.311e-271 862.0
TLS2_k127_4809664_1 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 490.0
TLS2_k127_4809664_2 COG3335 Transposase and inactivated derivatives K07494 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 462.0
TLS2_k127_4809664_3 Transposase - - - 0.000000000134 66.0
TLS2_k127_4809664_4 Serine dehydrogenase proteinase - - - 0.000007085 55.0
TLS2_k127_4809664_5 THUMP domain K06963 - - 0.00004552 50.0
TLS2_k127_4809664_6 THUMP domain K06963 - - 0.0003824 50.0
TLS2_k127_4850777_0 molybdopterin K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 366.0
TLS2_k127_4850777_1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004886 350.0
TLS2_k127_4850777_10 RDD family - - - 0.00000000000008104 78.0
TLS2_k127_4850777_11 COG0607 Rhodanese-related sulfurtransferase - - - 0.00000519 49.0
TLS2_k127_4850777_12 PFAM Rhodanese domain protein - - - 0.0001112 53.0
TLS2_k127_4850777_2 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006046 333.0
TLS2_k127_4850777_3 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 292.0
TLS2_k127_4850777_4 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000000000000000000000000001776 221.0
TLS2_k127_4850777_5 domain protein K01992,K06994 - - 0.0000000000000000000000000000000000000000000000000000000005292 215.0
TLS2_k127_4850777_6 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000001505 187.0
TLS2_k127_4850777_7 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000706 158.0
TLS2_k127_4850777_8 - - - - 0.0000000000000000000000000000001067 128.0
TLS2_k127_4850777_9 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000002688 115.0
TLS2_k127_4854109_0 Major Facilitator Superfamily - - - 2.409e-195 627.0
TLS2_k127_4854109_1 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005388 589.0
TLS2_k127_4854109_10 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000001712 53.0
TLS2_k127_4854109_11 methyltransferase - - - 0.0007259 45.0
TLS2_k127_4854109_2 Molydopterin dinucleotide binding domain K07306,K07309,K07310,K08352 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009390,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0033797,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494 1.8.5.3,1.8.5.5,1.97.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 613.0
TLS2_k127_4854109_3 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 441.0
TLS2_k127_4854109_4 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007133 442.0
TLS2_k127_4854109_5 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008957 345.0
TLS2_k127_4854109_6 ABC transporter substrate-binding protein K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006272 325.0
TLS2_k127_4854109_7 COG COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003577 312.0
TLS2_k127_4854109_8 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001293 296.0
TLS2_k127_4854109_9 N-terminal half of MaoC dehydratase K09709 - 4.2.1.153 0.000000000000000000000000000000000000000000000000000000000000000000000000001997 285.0
TLS2_k127_4859402_0 Phosphopantetheine attachment site K00652 - 2.3.1.47 1.813e-246 772.0
TLS2_k127_4859402_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006293 601.0
TLS2_k127_4859402_2 Signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 332.0
TLS2_k127_4859402_3 Dodecin - - - 0.000000000000000000002207 96.0
TLS2_k127_4863276_0 PFAM FAD linked oxidase domain protein - - - 1.095e-230 733.0
TLS2_k127_4863276_1 radical SAM domain protein K04034 - 1.21.98.3 1.646e-226 714.0
TLS2_k127_4863276_2 Belongs to the UbiD family K16874 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 462.0
TLS2_k127_4863276_3 arylformamidase activity - - - 0.00000000000000000000000000000000000000000000000001426 187.0
TLS2_k127_4863276_4 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000002718 141.0
TLS2_k127_4863276_5 membrane transporter protein K07090 - - 0.000000000000000000003858 106.0
TLS2_k127_4863276_6 Diacylglycerol kinase - - - 0.0000000000005594 82.0
TLS2_k127_4863276_7 Dienelactone hydrolase K01061 - 3.1.1.45 0.00000009483 63.0
TLS2_k127_4863276_8 ABC transporter substrate binding protein K01989 - - 0.0006611 48.0
TLS2_k127_4871266_0 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 485.0
TLS2_k127_4871266_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 426.0
TLS2_k127_4871266_10 High-affinity branched-chain amino acid transport protein (ABC superfamily K01996 - - 0.0000000000000000000000000000005502 124.0
TLS2_k127_4871266_12 Anti-sigma F factor - - - 0.000000002579 69.0
TLS2_k127_4871266_2 PFAM Acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 398.0
TLS2_k127_4871266_3 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 377.0
TLS2_k127_4871266_4 Succinyl-CoA ligase like flavodoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 384.0
TLS2_k127_4871266_5 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007835 356.0
TLS2_k127_4871266_6 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 333.0
TLS2_k127_4871266_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001061 265.0
TLS2_k127_4871266_8 Belongs to the ompA family - - - 0.0000000000000000000000000000000000002372 149.0
TLS2_k127_4871266_9 FecR protein - - - 0.00000000000000000000000000000002898 138.0
TLS2_k127_4926435_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.431e-255 823.0
TLS2_k127_4926435_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 7.804e-251 797.0
TLS2_k127_4926435_10 Uncharacterized ACR, COG1993 K09137 - - 0.00000000000000000000000000000000001252 142.0
TLS2_k127_4926435_11 PFAM Heat shock protein Hsp20 K13993 - - 0.00000000000000000000000000000002333 135.0
TLS2_k127_4926435_12 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000002659 112.0
TLS2_k127_4926435_13 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.000000000000000000000002975 116.0
TLS2_k127_4926435_14 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000003163 110.0
TLS2_k127_4926435_15 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000005633 107.0
TLS2_k127_4926435_16 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000001711 93.0
TLS2_k127_4926435_17 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000004574 95.0
TLS2_k127_4926435_18 Protein of unknown function (DUF2892) - - - 0.000000000000401 81.0
TLS2_k127_4926435_19 translation release factor activity K03265 - - 0.000000000001491 72.0
TLS2_k127_4926435_2 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 590.0
TLS2_k127_4926435_20 - - - - 0.0000005857 58.0
TLS2_k127_4926435_3 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 480.0
TLS2_k127_4926435_4 Hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 302.0
TLS2_k127_4926435_5 Formate/nitrite transporter K06212,K21993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003096 288.0
TLS2_k127_4926435_6 phosphoribosyltransferase K07100 - - 0.00000000000000000000000000000000000000000000000000000000000000000000132 255.0
TLS2_k127_4926435_7 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000317 204.0
TLS2_k127_4926435_8 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000001403 184.0
TLS2_k127_4926435_9 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.000000000000000000000000000000000001669 138.0
TLS2_k127_4935177_0 Glutamate synthase central domain K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.0 2296.0
TLS2_k127_4935177_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168,K07479 GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 1.45e-258 819.0
TLS2_k127_4935177_10 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 498.0
TLS2_k127_4935177_11 Belongs to the ALAD family K01698 GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 488.0
TLS2_k127_4935177_12 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006622 475.0
TLS2_k127_4935177_13 Aminotransferase class-III K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 474.0
TLS2_k127_4935177_14 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 433.0
TLS2_k127_4935177_15 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005006 433.0
TLS2_k127_4935177_16 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 445.0
TLS2_k127_4935177_17 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016625,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0047553,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 428.0
TLS2_k127_4935177_18 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 392.0
TLS2_k127_4935177_19 Cysteine-rich domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 406.0
TLS2_k127_4935177_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 8.681e-248 790.0
TLS2_k127_4935177_20 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 359.0
TLS2_k127_4935177_21 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 361.0
TLS2_k127_4935177_22 Belongs to the RtcB family K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004729 367.0
TLS2_k127_4935177_23 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 362.0
TLS2_k127_4935177_24 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007603 349.0
TLS2_k127_4935177_25 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K03438,K13292 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 316.0
TLS2_k127_4935177_26 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 311.0
TLS2_k127_4935177_27 peroxidase activity K00435 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008784 289.0
TLS2_k127_4935177_28 4Fe-4S binding domain K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004582 290.0
TLS2_k127_4935177_29 COG0583 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002917 277.0
TLS2_k127_4935177_3 Flavin containing amine oxidoreductase K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 4.802e-243 759.0
TLS2_k127_4935177_30 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000123 267.0
TLS2_k127_4935177_31 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000001175 259.0
TLS2_k127_4935177_32 FAD binding domain K11472 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004121 254.0
TLS2_k127_4935177_33 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000001812 245.0
TLS2_k127_4935177_34 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000031 261.0
TLS2_k127_4935177_35 TIGRFAM DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000001242 237.0
TLS2_k127_4935177_36 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000234 239.0
TLS2_k127_4935177_37 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000002196 220.0
TLS2_k127_4935177_38 PFAM molybdopterin oxidoreductase Fe4S4 region K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000007142 194.0
TLS2_k127_4935177_39 PFAM cytochrome c assembly protein - - - 0.0000000000000000000000000000000000000000000000000001466 195.0
TLS2_k127_4935177_4 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 9.896e-240 756.0
TLS2_k127_4935177_40 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.0000000000000000000000000000000000000000000000000005048 207.0
TLS2_k127_4935177_41 Pfam Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000001739 182.0
TLS2_k127_4935177_42 Domain of unknown function (DUF4383) - - - 0.00000000000000000000000000000000000000000009978 169.0
TLS2_k127_4935177_43 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000005928 153.0
TLS2_k127_4935177_44 Protein of unknown function (DUF2400) - - - 0.0000000000000000000000000000000000002342 160.0
TLS2_k127_4935177_45 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000004286 147.0
TLS2_k127_4935177_46 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000008053 151.0
TLS2_k127_4935177_47 Belongs to the ComB family K05979 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 0.00000000000000000000000000000000003264 143.0
TLS2_k127_4935177_48 Polysulfide reductase - - - 0.00000000000000000000000000000000005407 149.0
TLS2_k127_4935177_49 proteolysis K21140,K21147 - 2.7.7.80,2.8.1.11,3.13.1.6 0.00000000000000000000000000000186 129.0
TLS2_k127_4935177_5 4Fe-4S dicluster domain K00184 - - 1.743e-201 663.0
TLS2_k127_4935177_50 transcriptional regulator - - - 0.0000000000000000000000000001021 122.0
TLS2_k127_4935177_51 Protein involved in formate dehydrogenase formation K02380 - - 0.0000000000000000000001888 108.0
TLS2_k127_4935177_52 ThiF family K03148,K03636,K21029,K21147 - 2.7.7.73,2.7.7.80,2.8.1.11 0.0000000000000000000001904 110.0
TLS2_k127_4935177_53 Uncharacterized conserved protein (DUF2203) - - - 0.0000000000000000001779 94.0
TLS2_k127_4935177_54 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000009182 100.0
TLS2_k127_4935177_55 hydrolase K07025 - - 0.00000000000000003129 91.0
TLS2_k127_4935177_56 Quinol cytochrome c oxidoreductase membrane protein - - - 0.0000000000001041 78.0
TLS2_k127_4935177_57 ArsC family - - - 0.00000000001104 68.0
TLS2_k127_4935177_58 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000001609 75.0
TLS2_k127_4935177_59 - - - - 0.000000002466 61.0
TLS2_k127_4935177_6 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 604.0
TLS2_k127_4935177_7 Arginosuccinate synthase K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 586.0
TLS2_k127_4935177_8 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 564.0
TLS2_k127_4935177_9 FAD linked oxidases, C-terminal domain K00102,K00104 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.2.4,1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006258 543.0
TLS2_k127_4938597_0 Alanine dehydrogenase/PNT, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 484.0
TLS2_k127_4938597_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 411.0
TLS2_k127_4938597_10 COG0559 Branched-chain amino acid ABC-type transport system, permease components - - - 0.0000000000000000000000000000000000000000000000000000000000000000001723 241.0
TLS2_k127_4938597_11 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000003098 244.0
TLS2_k127_4938597_12 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000006464 251.0
TLS2_k127_4938597_13 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000005013 192.0
TLS2_k127_4938597_14 Enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000008704 188.0
TLS2_k127_4938597_15 UTRA K03710 - - 0.000000000000000000000000000000001432 144.0
TLS2_k127_4938597_16 Methicillin resistance protein K05363,K11693 - 2.3.2.10,2.3.2.16 0.0000000000000000000000000000001471 140.0
TLS2_k127_4938597_17 DegT/DnrJ/EryC1/StrS aminotransferase family K20429 - 2.6.1.33 0.0000000003266 72.0
TLS2_k127_4938597_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 407.0
TLS2_k127_4938597_3 Sugar (and other) transporter K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 393.0
TLS2_k127_4938597_4 mandelate racemase muconate lactonizing - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003785 345.0
TLS2_k127_4938597_5 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000336 347.0
TLS2_k127_4938597_6 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 323.0
TLS2_k127_4938597_7 PFAM ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001272 263.0
TLS2_k127_4938597_8 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006077 257.0
TLS2_k127_4938597_9 Branched-chain amino acid ATP-binding cassette transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000001787 256.0
TLS2_k127_4979438_0 ABC transporter transmembrane region - - - 0.0 1035.0
TLS2_k127_4979438_1 cytochrome C peroxidase - - - 1.089e-220 695.0
TLS2_k127_4979438_10 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000004485 152.0
TLS2_k127_4979438_11 Glycine-rich RNA-binding protein - GO:0000959,GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009414,GO:0009415,GO:0009451,GO:0009628,GO:0009651,GO:0009987,GO:0010035,GO:0016070,GO:0034641,GO:0042221,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1900864,GO:1901360,GO:1901363,GO:1901700 - 0.00000000000000000001616 97.0
TLS2_k127_4979438_12 metalloendopeptidase activity K06013 - 3.4.24.84 0.00000000000000000001971 100.0
TLS2_k127_4979438_13 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000002466 66.0
TLS2_k127_4979438_14 Protein of unknown function (DUF1706) - - - 0.000000002169 64.0
TLS2_k127_4979438_2 Glucose sorbosone K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 511.0
TLS2_k127_4979438_3 Beta-lactamase domain protein K06897 - 2.5.1.105 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008707 484.0
TLS2_k127_4979438_4 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 502.0
TLS2_k127_4979438_5 Cobalamin-independent synthase, Catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 426.0
TLS2_k127_4979438_6 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 424.0
TLS2_k127_4979438_7 Endonuclease Exonuclease Phosphatase - - - 0.0000000000000000000000000000000000000000000000000000003393 200.0
TLS2_k127_4979438_8 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000001086 195.0
TLS2_k127_4979438_9 response to pH - - - 0.00000000000000000000000000000000000005148 149.0
TLS2_k127_4993747_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 1.67e-321 1005.0
TLS2_k127_4993747_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 9.646e-251 782.0
TLS2_k127_4993747_10 COG1905 NADH ubiquinone oxidoreductase 24 kD subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004551 355.0
TLS2_k127_4993747_11 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 314.0
TLS2_k127_4993747_12 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 321.0
TLS2_k127_4993747_13 Belongs to the DapA family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008378 294.0
TLS2_k127_4993747_14 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000003807 275.0
TLS2_k127_4993747_15 carboxymethylenebutenolidase activity K01061,K07100 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000003194 226.0
TLS2_k127_4993747_16 Short-chain dehydrogenase reductase sdr K00059,K03366 - 1.1.1.100,1.1.1.304,1.1.1.76 0.000000000000000000000000000000000000000000000000000002416 200.0
TLS2_k127_4993747_17 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000007622 187.0
TLS2_k127_4993747_18 Protein of unknown function, DUF481 - - - 0.0000000000000000000000000000000003714 145.0
TLS2_k127_4993747_19 membrane - - - 0.0000000000000000000000000000001454 143.0
TLS2_k127_4993747_2 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 9.642e-206 649.0
TLS2_k127_4993747_20 Peptidase family M20/M25/M40 - - - 0.00000000000000000000000000001591 126.0
TLS2_k127_4993747_21 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000001101 122.0
TLS2_k127_4993747_22 Cbs domain K04767 - - 0.00000000000000000000000008332 115.0
TLS2_k127_4993747_23 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000008481 121.0
TLS2_k127_4993747_24 Archease protein family (MTH1598/TM1083) - - - 0.000000000000000000000002771 109.0
TLS2_k127_4993747_25 Cbs domain K04767 - - 0.00000000000000000000609 106.0
TLS2_k127_4993747_26 Cbs domain K04767 - - 0.00000000000000000004224 102.0
TLS2_k127_4993747_27 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000004081 74.0
TLS2_k127_4993747_28 zinc ion binding K06204 - - 0.000000008337 68.0
TLS2_k127_4993747_3 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 619.0
TLS2_k127_4993747_4 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 466.0
TLS2_k127_4993747_5 Polysaccharide pyruvyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 411.0
TLS2_k127_4993747_6 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 389.0
TLS2_k127_4993747_7 HflC and HflK could encode or regulate a protease K04088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 380.0
TLS2_k127_4993747_8 SPFH domain Band 7 family protein 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 377.0
TLS2_k127_4993747_9 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 376.0
TLS2_k127_5000707_0 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009149 261.0
TLS2_k127_5000707_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000001956 224.0
TLS2_k127_5000707_2 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000003791 186.0
TLS2_k127_5000707_3 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000001705 182.0
TLS2_k127_5000707_4 copper resistance K07245 - - 0.0006424 50.0
TLS2_k127_5023401_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1315.0
TLS2_k127_5023401_1 Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007985 332.0
TLS2_k127_5023401_10 PRC-barrel domain - - - 0.000000000000000002625 94.0
TLS2_k127_5023401_2 C-terminal, D2-small domain, of ClpB protein K03695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 325.0
TLS2_k127_5023401_3 4Fe-4S dicluster domain K00124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 285.0
TLS2_k127_5023401_4 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001411 289.0
TLS2_k127_5023401_5 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000216 282.0
TLS2_k127_5023401_6 Pfam:UPF0118 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001304 246.0
TLS2_k127_5023401_7 Protein involved in formate dehydrogenase formation K02380 - - 0.000000000000000000000000000000000000000000000000000000000000005557 229.0
TLS2_k127_5023401_8 4Fe-4S dicluster domain K00124 - - 0.000000000000000000000000000000000006671 139.0
TLS2_k127_5023401_9 - - - - 0.00000000000000000000000001177 124.0
TLS2_k127_5045715_0 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007233 603.0
TLS2_k127_5045715_1 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003983 518.0
TLS2_k127_5045715_10 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000509 243.0
TLS2_k127_5045715_11 inositol 2-dehydrogenase activity K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000002018 235.0
TLS2_k127_5045715_12 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000002163 230.0
TLS2_k127_5045715_13 RmlD substrate binding domain - - - 0.0000000000000000000000000000000000000000000000003094 195.0
TLS2_k127_5045715_14 D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000001525 167.0
TLS2_k127_5045715_15 Glycosyltransferase like family 2 - - - 0.0000000000000006171 92.0
TLS2_k127_5045715_16 Methyltransferase FkbM domain - - - 0.00000000001313 74.0
TLS2_k127_5045715_2 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162,K21417 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 485.0
TLS2_k127_5045715_3 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 442.0
TLS2_k127_5045715_4 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 439.0
TLS2_k127_5045715_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K21416 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 396.0
TLS2_k127_5045715_6 Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003704 342.0
TLS2_k127_5045715_7 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001567 295.0
TLS2_k127_5045715_8 D-glycero-D-manno-heptose 7-phosphate metabolic process K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000296 273.0
TLS2_k127_5045715_9 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001567 282.0
TLS2_k127_5057722_0 COG0747 ABC-type dipeptide transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 434.0
TLS2_k127_5057722_1 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 368.0
TLS2_k127_5057722_2 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004186 336.0
TLS2_k127_5057722_3 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007483 291.0
TLS2_k127_5057722_4 transporter K02034,K12370 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000699 278.0
TLS2_k127_5057722_5 E COG0747 ABC-type dipeptide transport system, periplasmic component - - - 0.000601 43.0
TLS2_k127_5069675_0 Adenylate and Guanylate cyclase catalytic domain - - - 1.517e-317 1006.0
TLS2_k127_5069675_1 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000006685 179.0
TLS2_k127_5069675_2 - K12963 - - 0.0000000000000000000000000000000000002469 143.0
TLS2_k127_5069675_3 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.000000000000000000000001953 108.0
TLS2_k127_5069675_4 COG1175 ABC-type sugar transport systems, permease components K02025 - - 0.000000000000000000000006972 104.0
TLS2_k127_5069675_5 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.0000000000001038 77.0
TLS2_k127_5069675_6 PFAM binding-protein-dependent transport systems inner membrane component K02025,K10118,K17316 - - 0.0000002086 63.0
TLS2_k127_5069675_7 response to nickel cation - - - 0.0001553 53.0
TLS2_k127_5069675_8 Belongs to the Nudix hydrolase family K03426 - 3.6.1.22 0.0006012 50.0
TLS2_k127_5069897_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 9.222e-309 963.0
TLS2_k127_5069897_1 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 3.917e-236 763.0
TLS2_k127_5069897_10 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000193 179.0
TLS2_k127_5069897_11 carbon monoxide dehydrogenase subunit G K09386 - - 0.0000000000000000001603 103.0
TLS2_k127_5069897_12 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000761 86.0
TLS2_k127_5069897_13 creatinine amidohydrolase family protein K01470 - 3.5.2.10 0.00000000004947 66.0
TLS2_k127_5069897_14 Tripartite tricarboxylate transporter TctB family - - - 0.0005898 51.0
TLS2_k127_5069897_2 Psort location CytoplasmicMembrane, score - - - 1.379e-207 674.0
TLS2_k127_5069897_3 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 381.0
TLS2_k127_5069897_4 Belongs to the UbiD family K03182,K16874 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007854 366.0
TLS2_k127_5069897_5 Tripartite tricarboxylate transporter TctA family K07793 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007611 321.0
TLS2_k127_5069897_6 Tripartite tricarboxylate transporter TctA family K07793 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005527 260.0
TLS2_k127_5069897_7 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000006495 220.0
TLS2_k127_5069897_8 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000002983 226.0
TLS2_k127_5069897_9 [2Fe-2S] binding domain - - - 0.00000000000000000000000000000000000000000000000000001168 198.0
TLS2_k127_5102870_0 PFAM copper amine oxidase K00276 - 1.4.3.21 1.209e-288 899.0
TLS2_k127_5102870_1 xanthine dehydrogenase, a b hammerhead - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 547.0
TLS2_k127_5102870_10 Protein of unknown function (DUF917) K09703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006101 304.0
TLS2_k127_5102870_11 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001002 290.0
TLS2_k127_5102870_12 PFAM binding-protein-dependent transport systems inner membrane component K02054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000769 267.0
TLS2_k127_5102870_13 Required for the activity of the bacterial periplasmic transport system of putrescine K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007486 267.0
TLS2_k127_5102870_14 PFAM binding-protein-dependent transport systems inner membrane component K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005002 269.0
TLS2_k127_5102870_15 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003074 267.0
TLS2_k127_5102870_16 Iron-containing redox enzyme K06137 - 1.3.3.11 0.0000000000000000000000000000000000000000000000000000000000000008352 247.0
TLS2_k127_5102870_17 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000001331 219.0
TLS2_k127_5102870_18 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000002487 203.0
TLS2_k127_5102870_19 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518,K13483 - 1.2.5.3 0.000000000000000000000000000000000000000000000000003255 194.0
TLS2_k127_5102870_2 Protein of unknown function (DUF1177) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 403.0
TLS2_k127_5102870_20 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000002667 196.0
TLS2_k127_5102870_21 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000002532 185.0
TLS2_k127_5102870_22 shikimate kinase activity K00891,K13829 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000009344 180.0
TLS2_k127_5102870_24 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000273 156.0
TLS2_k127_5102870_25 Transcriptional regulator - - - 0.00000000000000000000000000000001069 138.0
TLS2_k127_5102870_26 FCD - - - 0.000000000000000000000000006123 119.0
TLS2_k127_5102870_27 Belongs to the peptidase S51 family K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.000000000000000000000008838 105.0
TLS2_k127_5102870_28 PFAM short-chain dehydrogenase reductase SDR K00059,K00068,K03366 - 1.1.1.100,1.1.1.140,1.1.1.304,1.1.1.76 0.0000000000000000000008475 110.0
TLS2_k127_5102870_29 (Rieske (2Fe-2S) domain) K00363,K05710 - 1.7.1.15 0.00000000000000000002933 103.0
TLS2_k127_5102870_3 import. Responsible for energy coupling to the transport system K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009208 385.0
TLS2_k127_5102870_30 Belongs to the peptidase S51 family K05995 - 3.4.13.21 0.000000000000000002567 87.0
TLS2_k127_5102870_31 Haem-degrading - - - 0.000000001149 68.0
TLS2_k127_5102870_33 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000007572 60.0
TLS2_k127_5102870_34 PFAM thiamineS protein - - - 0.00001184 51.0
TLS2_k127_5102870_35 toxin-antitoxin pair type II binding - - - 0.00004407 55.0
TLS2_k127_5102870_4 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008191 356.0
TLS2_k127_5102870_5 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 353.0
TLS2_k127_5102870_6 PFAM FAD dependent oxidoreductase K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000361 364.0
TLS2_k127_5102870_7 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 347.0
TLS2_k127_5102870_8 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 335.0
TLS2_k127_5102870_9 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006011 335.0
TLS2_k127_5107282_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 3.691e-270 844.0
TLS2_k127_5107282_1 NMT1-like family K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 385.0
TLS2_k127_5107282_2 Amidohydrolase family K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 386.0
TLS2_k127_5107282_3 conserved protein (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000767 381.0
TLS2_k127_5107282_4 Threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007895 394.0
TLS2_k127_5107282_5 Biotin-lipoyl like K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000001415 245.0
TLS2_k127_5107282_6 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.0000000000000000000000000000000000000000000001281 169.0
TLS2_k127_5107282_7 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000000000000000319 128.0
TLS2_k127_5153661_0 Ribosomal protein S1 K02945,K03527,K07571 - 1.17.7.4 1.151e-209 665.0
TLS2_k127_5153661_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.074e-209 681.0
TLS2_k127_5153661_10 Protein similar to CwfJ C-terminus 1 K19710 - 2.7.7.53 0.00000000000000000000000000000000000000000002571 170.0
TLS2_k127_5153661_12 His Kinase A (phosphoacceptor) domain K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000988 137.0
TLS2_k127_5153661_13 regulation of translation K05788 - - 0.000000000000000000000000000000000406 134.0
TLS2_k127_5153661_14 Histidine kinase A domain protein - - - 0.000000000000000000000000000007062 126.0
TLS2_k127_5153661_15 CDP-alcohol phosphatidyltransferase K00995,K08744 - 2.7.8.41,2.7.8.5 0.00000000000000000000000002771 125.0
TLS2_k127_5153661_16 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000002977 107.0
TLS2_k127_5153661_17 PFAM regulatory protein, MerR - - - 0.000000000000000000001784 102.0
TLS2_k127_5153661_2 Ferrous iron transport protein B K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 412.0
TLS2_k127_5153661_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 378.0
TLS2_k127_5153661_4 Protein of unknown function (DUF512) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000278 361.0
TLS2_k127_5153661_5 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 370.0
TLS2_k127_5153661_6 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009219 276.0
TLS2_k127_5153661_7 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000009412 263.0
TLS2_k127_5153661_8 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002648 259.0
TLS2_k127_5153661_9 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000001854 247.0
TLS2_k127_5158884_0 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 415.0
TLS2_k127_5158884_1 Bacterial extracellular solute-binding protein K02012,K02055 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008237 350.0
TLS2_k127_5158884_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 367.0
TLS2_k127_5158884_3 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001366 282.0
TLS2_k127_5158884_4 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000009801 215.0
TLS2_k127_5158884_5 Endoribonuclease L-PSP - - - 0.0000000000000000003739 93.0
TLS2_k127_5160083_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 9.959e-269 863.0
TLS2_k127_5160083_1 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 2.738e-196 624.0
TLS2_k127_5160083_10 PFAM Peptidase M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005228 274.0
TLS2_k127_5160083_11 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008708 258.0
TLS2_k127_5160083_12 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000001601 233.0
TLS2_k127_5160083_13 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000000004012 203.0
TLS2_k127_5160083_14 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000003799 185.0
TLS2_k127_5160083_15 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000003765 155.0
TLS2_k127_5160083_16 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.000000000000000000000000000000000001979 153.0
TLS2_k127_5160083_17 Bacterial extracellular solute-binding protein K05813 - - 0.000000000000000000000009254 103.0
TLS2_k127_5160083_18 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.000000000009522 69.0
TLS2_k127_5160083_19 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000001038 62.0
TLS2_k127_5160083_2 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 604.0
TLS2_k127_5160083_3 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 597.0
TLS2_k127_5160083_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005935 401.0
TLS2_k127_5160083_5 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003591 367.0
TLS2_k127_5160083_6 ABC-type sugar transport system periplasmic component K05813 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 356.0
TLS2_k127_5160083_7 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 307.0
TLS2_k127_5160083_8 probably responsible for the translocation of the substrate across the membrane K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 314.0
TLS2_k127_5160083_9 COGs COG0647 sugar phosphatase of the HAD superfamily K01101,K02566 - 3.1.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001965 276.0
TLS2_k127_5168807_0 TRAP dicarboxylate transporter, DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 526.0
TLS2_k127_5168807_1 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003361 259.0
TLS2_k127_5168807_2 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000005047 224.0
TLS2_k127_5168807_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000341 204.0
TLS2_k127_5168807_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000001531 206.0
TLS2_k127_5168807_5 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000001469 180.0
TLS2_k127_5168807_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000001876 97.0
TLS2_k127_5173669_0 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 1.163e-310 979.0
TLS2_k127_5173669_1 Dehydrogenase - - - 1.025e-222 715.0
TLS2_k127_5173669_10 Pyridoxamine 5'-phosphate oxidase K07226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000144 273.0
TLS2_k127_5173669_11 phosphorelay sensor kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007108 285.0
TLS2_k127_5173669_12 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001393 252.0
TLS2_k127_5173669_13 NUDIX domain K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000000000001007 226.0
TLS2_k127_5173669_14 pfkB family carbohydrate kinase K00874 - 2.7.1.45 0.0000000000000000000000000000000000000000000000000000000000004604 222.0
TLS2_k127_5173669_15 - - - - 0.00000000000000000000000000000000000000000000000000000000001996 215.0
TLS2_k127_5173669_16 transglutaminase-like - - - 0.0000000000000000000000000000000000000000000000000000000004066 225.0
TLS2_k127_5173669_17 GDP-mannose mannosyl hydrolase activity K18445 - 3.6.1.61 0.0000000000000000000000000000000000000000458 158.0
TLS2_k127_5173669_18 A predicted alpha-helical domain with a conserved ER motif. - - - 0.0000000000000000000000000000000002451 149.0
TLS2_k127_5173669_19 Cupin domain K11312 - - 0.00000000000000000000000000001465 132.0
TLS2_k127_5173669_2 FAD dependent oxidoreductase K13796 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 602.0
TLS2_k127_5173669_20 EthD domain - - - 0.0000000000000000000000000001049 118.0
TLS2_k127_5173669_21 HD domain - - - 0.00000000000000000000000003107 126.0
TLS2_k127_5173669_22 Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000008804 111.0
TLS2_k127_5173669_23 Bacterial regulatory protein, Fis family K02481,K07713,K07714 - - 0.00000000000000000005116 103.0
TLS2_k127_5173669_24 chlorophyll binding - - - 0.000000000000000005121 100.0
TLS2_k127_5173669_25 AMP-binding enzyme K01912 - 6.2.1.30 0.000000000000000005787 86.0
TLS2_k127_5173669_26 - K00712 - 2.4.1.52 0.000000000000002131 91.0
TLS2_k127_5173669_27 amine dehydrogenase activity K00355 - 1.6.5.2 0.000000000001285 82.0
TLS2_k127_5173669_28 ThiS family K03154 - - 0.00000000002229 72.0
TLS2_k127_5173669_29 DinB superfamily - - - 0.0002211 51.0
TLS2_k127_5173669_3 A circularly permuted ATPgrasp - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000529 561.0
TLS2_k127_5173669_4 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 434.0
TLS2_k127_5173669_5 Belongs to the TtcA family K21947 - 2.8.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 347.0
TLS2_k127_5173669_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 317.0
TLS2_k127_5173669_7 Histidine kinase K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 309.0
TLS2_k127_5173669_8 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003321 309.0
TLS2_k127_5173669_9 ATP-dependent helicase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001495 289.0
TLS2_k127_5184006_0 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005532 469.0
TLS2_k127_5184006_1 alcohol dehydrogenase K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006009 391.0
TLS2_k127_5184006_2 (ABC) transporter, permease K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 342.0
TLS2_k127_5184006_3 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 299.0
TLS2_k127_5184006_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000007728 249.0
TLS2_k127_5184006_5 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000001837 237.0
TLS2_k127_5184006_6 Sugar-specific transcriptional regulator TrmB - - - 0.0000000000000000000000000000000000000000001411 165.0
TLS2_k127_5184006_7 - - - - 0.0000000000000000000000000879 119.0
TLS2_k127_5184006_8 dehydratase - - - 0.0000000000000000000005437 96.0
TLS2_k127_5224648_0 PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III domain protein - - - 7.529e-246 788.0
TLS2_k127_5224648_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003763 548.0
TLS2_k127_5224648_10 Alkyl hydroperoxide reductase thiol specific antioxidant Mal allergens family protein K03564 - 1.11.1.15 0.0000000002832 64.0
TLS2_k127_5224648_11 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 0.00000085 61.0
TLS2_k127_5224648_12 - - - - 0.0002116 52.0
TLS2_k127_5224648_2 PFAM sodium calcium exchanger membrane region K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 378.0
TLS2_k127_5224648_3 Rhodanese Homology Domain K01011,K01613 - 2.8.1.1,2.8.1.2,4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000007638 270.0
TLS2_k127_5224648_4 Thioredoxin domain - - - 0.00000000000000000000000000000000000001406 149.0
TLS2_k127_5224648_5 Bacterial PH domain - - - 0.0000000000000000000000000000000004967 141.0
TLS2_k127_5224648_6 TIGRFAM DNA binding domain protein, excisionase family K22491 - - 0.000000000000000000000000000000006331 136.0
TLS2_k127_5224648_7 Protein of unknown function, DUF393 - - - 0.000000000000000000001055 102.0
TLS2_k127_5224648_8 TIGRFAM Glutaredoxin-like domain protein - - - 0.000000000000000001058 87.0
TLS2_k127_5224648_9 PFAM AIG2-like - - - 0.00000000000003192 83.0
TLS2_k127_5235302_0 Aconitase C-terminal domain K01681 - 4.2.1.3 2.172e-282 879.0
TLS2_k127_5235302_1 isocitrate K00031 - 1.1.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 599.0
TLS2_k127_5235302_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005015 426.0
TLS2_k127_5235302_3 TIGRFAM hydro-lyase, Fe-S type, tartrate fumarate subfamily, alpha subunit K01677,K03779 - 4.2.1.2,4.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 351.0
TLS2_k127_5235302_4 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008201 292.0
TLS2_k127_5235302_5 Hydro-lyase, Fe-S type, tartrate fumarate subfamily, beta subunit K01678 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000002588 243.0
TLS2_k127_5268438_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 2.326e-206 670.0
TLS2_k127_5268438_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009419 452.0
TLS2_k127_5268438_10 Protein of unknown function (DUF448) K07742 - - 0.00000000000002027 77.0
TLS2_k127_5268438_2 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 393.0
TLS2_k127_5268438_3 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001393 266.0
TLS2_k127_5268438_4 DHH family K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000007899 241.0
TLS2_k127_5268438_5 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000216 248.0
TLS2_k127_5268438_6 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000004233 136.0
TLS2_k127_5268438_7 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000003224 119.0
TLS2_k127_5268438_8 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000001566 105.0
TLS2_k127_5268438_9 Protein of unknown function (DUF503) K09764 - - 0.0000000000000000001928 91.0
TLS2_k127_5302955_0 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain K01596,K01610 - 4.1.1.32,4.1.1.49 2.076e-251 803.0
TLS2_k127_5302955_1 ABC-type dipeptide transport system periplasmic component K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 414.0
TLS2_k127_5302955_10 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog)) K04762,K06179,K06180 GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009987,GO:0016070,GO:0033554,GO:0034605,GO:0034641,GO:0043021,GO:0043023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.23,5.4.99.24 0.000000000000000000000000007197 113.0
TLS2_k127_5302955_11 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000006704 83.0
TLS2_k127_5302955_12 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000028 87.0
TLS2_k127_5302955_13 repeat-containing protein - - - 0.0000000000105 78.0
TLS2_k127_5302955_14 - - - - 0.00000002611 65.0
TLS2_k127_5302955_15 PEP-CTERM system TPR-repeat lipoprotein - - - 0.00005522 57.0
TLS2_k127_5302955_2 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 373.0
TLS2_k127_5302955_3 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 353.0
TLS2_k127_5302955_4 Gamma-glutamyltranspeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 355.0
TLS2_k127_5302955_5 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004107 326.0
TLS2_k127_5302955_6 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003875 304.0
TLS2_k127_5302955_7 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.0000000000000000000000000000000000002096 158.0
TLS2_k127_5302955_8 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000003945 140.0
TLS2_k127_5339651_0 helicase K08282 - 2.7.11.1 1.328e-308 973.0
TLS2_k127_5339651_1 DNA topoisomerase II activity K03167 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 525.0
TLS2_k127_5339651_10 peroxiredoxin activity K03564 - 1.11.1.15 0.00000000001411 68.0
TLS2_k127_5339651_11 Redoxin K03386 - 1.11.1.15 0.00000001285 59.0
TLS2_k127_5339651_12 CHAT domain - - - 0.0001305 53.0
TLS2_k127_5339651_2 the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 506.0
TLS2_k127_5339651_3 alpha/beta hydrolase fold K01066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007778 346.0
TLS2_k127_5339651_4 Predicted membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002064 261.0
TLS2_k127_5339651_5 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000004549 176.0
TLS2_k127_5339651_6 protein conserved in cyanobacteria - - - 0.000000000000000000000000000000000000003286 154.0
TLS2_k127_5339651_7 Pfam Amidohydrolase K07045 - - 0.0000000000000000000000000000000000002024 158.0
TLS2_k127_5339651_8 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.00000000000000000002207 99.0
TLS2_k127_5339651_9 Protein of unknown function (DUF3175) - - - 0.00000000000000000006551 97.0
TLS2_k127_5342689_0 NADH oxidase - - - 3.742e-200 635.0
TLS2_k127_5342689_1 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009803 378.0
TLS2_k127_5342689_2 Enoyl-(Acyl carrier protein) reductase K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000000000000001369 229.0
TLS2_k127_5342689_3 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000656 194.0
TLS2_k127_5342689_4 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.00000000000000000000000000000000000001191 153.0
TLS2_k127_5342689_5 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.00000000000000000000000000000000002419 142.0
TLS2_k127_5342689_6 oxidation-reduction process - - - 0.000000000000000000000000005714 125.0
TLS2_k127_5342689_7 Tautomerase enzyme K01821 - 5.3.2.6 0.000000000000000003948 85.0
TLS2_k127_5342689_8 Phenylacetate-CoA oxygenase K02609 - 1.14.13.149 0.0000003902 61.0
TLS2_k127_5520114_0 Permease K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007355 331.0
TLS2_k127_5520114_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 299.0
TLS2_k127_5520114_2 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 291.0
TLS2_k127_5520114_3 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001293 299.0
TLS2_k127_5520114_4 COGs COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003992 271.0
TLS2_k127_5520114_5 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008612 271.0
TLS2_k127_5520114_6 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001348 259.0
TLS2_k127_5520114_7 Carboxymuconolactone decarboxylase family - - - 0.000000003354 63.0
TLS2_k127_5554338_0 transmembrane transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 462.0
TLS2_k127_5554338_1 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 398.0
TLS2_k127_5554338_2 Glycosyl Hydrolase Family 88 K18581 - 3.2.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 360.0
TLS2_k127_5554338_3 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007498 380.0
TLS2_k127_5554338_4 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 324.0
TLS2_k127_5554338_5 Phosphatidylethanolamine-binding protein K06910 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001513 280.0
TLS2_k127_5554338_6 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001661 259.0
TLS2_k127_5554338_7 Protein of unknown function (DUF421) - - - 0.00000008045 56.0
TLS2_k127_55804_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1041.0
TLS2_k127_55804_1 leucyl-tRNA aminoacylation K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1021.0
TLS2_k127_55804_10 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 393.0
TLS2_k127_55804_11 SIS domain K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 361.0
TLS2_k127_55804_12 PFAM DAHP synthetase I KDSA K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 355.0
TLS2_k127_55804_13 lipopolysaccharide transport protein B ATP-binding component of ABC superfamily K01990,K06861 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007359 321.0
TLS2_k127_55804_14 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008136 304.0
TLS2_k127_55804_15 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004152 294.0
TLS2_k127_55804_16 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001895 284.0
TLS2_k127_55804_17 Phage integrase, N-terminal SAM-like domain K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002661 276.0
TLS2_k127_55804_18 Permease YjgP YjgQ family protein K07091,K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001198 271.0
TLS2_k127_55804_19 Bifunctional phosphoglucose phosphomannose isomerase K15916 - 5.3.1.8,5.3.1.9 0.0000000000000000000000000000000000000000000000001108 196.0
TLS2_k127_55804_2 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 2.93e-321 1021.0
TLS2_k127_55804_20 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000005258 183.0
TLS2_k127_55804_21 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000005035 167.0
TLS2_k127_55804_22 TIGRFAM DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000000000008748 89.0
TLS2_k127_55804_23 Evidence 5 No homology to any previously reported sequences K03643 GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - 0.000000000000001622 91.0
TLS2_k127_55804_24 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000001523 74.0
TLS2_k127_55804_25 OstA-like protein K09774 - - 0.0000000004159 71.0
TLS2_k127_55804_26 Lipopolysaccharide-assembly, LptC-related K09774,K11719 - - 0.000003689 56.0
TLS2_k127_55804_3 DNA polymerase K02337 GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 1.825e-236 742.0
TLS2_k127_55804_4 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 1.269e-235 739.0
TLS2_k127_55804_5 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 1.568e-202 643.0
TLS2_k127_55804_6 S-adenosylmethionine synthetase, C-terminal domain K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 554.0
TLS2_k127_55804_7 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 529.0
TLS2_k127_55804_8 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 510.0
TLS2_k127_55804_9 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 413.0
TLS2_k127_5624507_0 Glycosyltransferase family 20 - - - 2.387e-210 681.0
TLS2_k127_5624507_1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 408.0
TLS2_k127_5624507_2 response regulator receiver K07714,K10943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 382.0
TLS2_k127_5624507_3 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 330.0
TLS2_k127_5624507_4 PFAM phosphoesterase, RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 315.0
TLS2_k127_5624507_5 ubiE/COQ5 methyltransferase family K00570 - 2.1.1.17,2.1.1.71 0.00000000000000000000000000000000000000000000000000000000000000000000000003171 256.0
TLS2_k127_5638727_0 Two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 518.0
TLS2_k127_5638727_1 Histone deacetylase domain K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 343.0
TLS2_k127_5638727_10 TIGRFAM DNA polymerase III, delta prime subunit K02341 - 2.7.7.7 0.00000000000000000000000000007246 128.0
TLS2_k127_5638727_11 PFAM UspA domain protein - - - 0.0000000000000000000000003195 113.0
TLS2_k127_5638727_12 Universal stress protein family - - - 0.00000000000000000000002394 105.0
TLS2_k127_5638727_13 PFAM regulatory protein LysR K02019 - - 0.00000000000000001279 93.0
TLS2_k127_5638727_14 Universal stress protein - - - 0.00000000000000002907 92.0
TLS2_k127_5638727_15 Chromatin associated protein KTI12 K00860 - 2.7.1.25 0.0000001665 58.0
TLS2_k127_5638727_16 His Kinase A (phosphoacceptor) domain - - - 0.0001056 46.0
TLS2_k127_5638727_17 Protein of unknown function (DUF465) - - - 0.0005959 50.0
TLS2_k127_5638727_2 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003638 335.0
TLS2_k127_5638727_3 Belongs to the ABC transporter superfamily K02017 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 325.0
TLS2_k127_5638727_4 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02045,K02049,K02068,K02071,K06857,K10112,K11072 - 3.6.3.25,3.6.3.30,3.6.3.31,3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005893 326.0
TLS2_k127_5638727_5 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 296.0
TLS2_k127_5638727_6 molybdate ABC transporter, permease protein K02017,K02018 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000003985 241.0
TLS2_k127_5638727_7 Bacterial extracellular solute-binding protein K02020 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704 - 0.000000000000000000000000000000000000000000000000000000002944 211.0
TLS2_k127_5638727_8 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000006713 188.0
TLS2_k127_5638727_9 Bacterial extracellular solute-binding protein K02020 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704 - 0.000000000000000000000000000000006925 138.0
TLS2_k127_5709293_0 Acyl-CoA dehydrogenase, middle domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 385.0
TLS2_k127_5709293_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 358.0
TLS2_k127_5709293_10 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000004463 197.0
TLS2_k127_5709293_11 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K00219,K01069 - 1.3.1.34,3.1.2.6 0.000000000000000000000001897 120.0
TLS2_k127_5709293_12 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000006466 69.0
TLS2_k127_5709293_2 Ethanolamine utilization protein EutJ K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 349.0
TLS2_k127_5709293_3 Peptidase family M28 K02083 - 3.5.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006228 319.0
TLS2_k127_5709293_4 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005637 293.0
TLS2_k127_5709293_5 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007746 271.0
TLS2_k127_5709293_6 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006371 250.0
TLS2_k127_5709293_7 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000005652 239.0
TLS2_k127_5709293_8 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000001576 228.0
TLS2_k127_5709293_9 PFAM glutamine amidotransferase class-I K07010 - - 0.000000000000000000000000000000000000000000000000000000000003537 216.0
TLS2_k127_5744852_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 - 3.4.21.83 2.209e-243 769.0
TLS2_k127_5744852_1 Copper resistance protein D K07245 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 323.0
TLS2_k127_5744852_2 Nitrile hydratase, alpha chain K01721 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004938 305.0
TLS2_k127_5744852_3 Nitrile hydratase beta subunit - - - 0.000000000000000000000000000000000000002239 159.0
TLS2_k127_5744852_4 NHase catalyzes the hydration of various nitrile compounds to the corresponding amides K20807 - 4.2.1.84 0.000000000000000000000000000000000008334 147.0
TLS2_k127_5744852_5 NHase catalyzes the hydration of various nitrile compounds to the corresponding amides K20807 - 4.2.1.84 0.00000000000000000000000000000000001317 144.0
TLS2_k127_5744852_6 Hydrogenase urease accessory protein K03192 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000009797 110.0
TLS2_k127_5744852_7 Serine aminopeptidase, S33 - - - 0.00000000000001406 86.0
TLS2_k127_5755585_0 Belongs to the aldehyde dehydrogenase family K13821 - 1.2.1.88,1.5.5.2 2.132e-280 906.0
TLS2_k127_5755585_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 6.198e-204 643.0
TLS2_k127_5755585_10 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 310.0
TLS2_k127_5755585_11 Phosphomethylpyrimidine kinase K00941,K14153,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 293.0
TLS2_k127_5755585_12 NADH pyrophosphatase zinc ribbon domain K03426 - 3.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009804 296.0
TLS2_k127_5755585_13 serine-type endopeptidase activity K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000321 303.0
TLS2_k127_5755585_14 Creatinase/Prolidase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001387 276.0
TLS2_k127_5755585_15 PFAM luciferase-like K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000002913 257.0
TLS2_k127_5755585_16 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000007922 248.0
TLS2_k127_5755585_17 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000003412 250.0
TLS2_k127_5755585_18 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000151 231.0
TLS2_k127_5755585_19 PP-loop family K14058 - - 0.00000000000000000000000000000000000000000000000000000000006225 213.0
TLS2_k127_5755585_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 584.0
TLS2_k127_5755585_20 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000005773 187.0
TLS2_k127_5755585_21 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000008483 186.0
TLS2_k127_5755585_22 intermembrane phospholipid transfer K07323 - - 0.0000000000000000000000000000000000000000000000001015 185.0
TLS2_k127_5755585_23 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000009769 171.0
TLS2_k127_5755585_24 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000004982 164.0
TLS2_k127_5755585_25 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000006302 169.0
TLS2_k127_5755585_26 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000008917 176.0
TLS2_k127_5755585_27 Domain of unknown function (DUF2383) - - - 0.0000000000000000000000000000000003911 138.0
TLS2_k127_5755585_28 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000002586 129.0
TLS2_k127_5755585_29 BON domain - - - 0.0000000000000000000005068 112.0
TLS2_k127_5755585_3 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007023 526.0
TLS2_k127_5755585_30 protein conserved in bacteria K09793 - - 0.0000000000000008944 90.0
TLS2_k127_5755585_31 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.00000001179 68.0
TLS2_k127_5755585_32 Domain of unknown function (DUF2382) - - - 0.0000001547 60.0
TLS2_k127_5755585_33 BON domain - - - 0.000001863 58.0
TLS2_k127_5755585_34 PFAM Tetratricopeptide repeat - - - 0.000005158 60.0
TLS2_k127_5755585_35 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000009161 49.0
TLS2_k127_5755585_36 PFAM Adenylate and Guanylate cyclase catalytic domain - - - 0.0001157 47.0
TLS2_k127_5755585_4 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 501.0
TLS2_k127_5755585_5 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 445.0
TLS2_k127_5755585_6 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007038 376.0
TLS2_k127_5755585_7 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002811 376.0
TLS2_k127_5755585_8 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K04091 - 1.14.14.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 352.0
TLS2_k127_5755585_9 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 320.0
TLS2_k127_5782917_0 Carbamoyltransferase K00612 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009832 374.0
TLS2_k127_5782917_1 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001661 250.0
TLS2_k127_5782917_2 DJ-1/PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000000003376 243.0
TLS2_k127_5782917_3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000003337 220.0
TLS2_k127_5782917_4 PFAM NAD dependent epimerase dehydratase family K01710,K01784 - 4.2.1.46,5.1.3.2 0.000000000000000000000000000000000000000000000000000002884 203.0
TLS2_k127_5782917_5 Lrp/AsnC ligand binding domain - - - 0.0000000001304 73.0
TLS2_k127_5782917_6 - - - - 0.00000386 51.0
TLS2_k127_5786322_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 3.36e-306 955.0
TLS2_k127_5786322_1 Adenylate and Guanylate cyclase catalytic domain - - - 6.239e-262 845.0
TLS2_k127_5786322_10 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 357.0
TLS2_k127_5786322_11 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 304.0
TLS2_k127_5786322_12 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 305.0
TLS2_k127_5786322_13 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 301.0
TLS2_k127_5786322_14 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004846 282.0
TLS2_k127_5786322_15 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005278 267.0
TLS2_k127_5786322_16 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007159 271.0
TLS2_k127_5786322_17 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000004587 261.0
TLS2_k127_5786322_18 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007005 266.0
TLS2_k127_5786322_19 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000005548 236.0
TLS2_k127_5786322_2 PFAM NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 564.0
TLS2_k127_5786322_20 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000003204 239.0
TLS2_k127_5786322_21 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000001146 226.0
TLS2_k127_5786322_22 TIGRFAM acetylornithine deacetylase or succinyl- diaminopimelate desuccinylase K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000001732 221.0
TLS2_k127_5786322_23 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000001995 213.0
TLS2_k127_5786322_24 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000008477 213.0
TLS2_k127_5786322_25 helix_turn_helix isocitrate lyase regulation K13641 - - 0.0000000000000000000000000000000000000000000000000005472 197.0
TLS2_k127_5786322_26 ABC transporter (Permease K01999 - - 0.0000000000000000000000000000000000000000001147 169.0
TLS2_k127_5786322_27 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000003695 119.0
TLS2_k127_5786322_28 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000001566 122.0
TLS2_k127_5786322_29 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000003306 104.0
TLS2_k127_5786322_3 Tripartite tricarboxylate transporter TctA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 520.0
TLS2_k127_5786322_30 Tripartite tricarboxylate transporter TctB family K07794 - - 0.0008789 47.0
TLS2_k127_5786322_4 Creatinase/Prolidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 494.0
TLS2_k127_5786322_5 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006994 438.0
TLS2_k127_5786322_6 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 447.0
TLS2_k127_5786322_7 PFAM Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009094 422.0
TLS2_k127_5786322_8 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 402.0
TLS2_k127_5786322_9 Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation K01305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 383.0
TLS2_k127_5821584_0 Domain of unknown function (DUF3459) K01236 - 3.2.1.141 3.48e-264 824.0
TLS2_k127_5821584_1 PFAM extracellular solute-binding protein, family 5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009894 527.0
TLS2_k127_5821584_2 Belongs to the ABC transporter superfamily K02031,K02032,K13896,K19229,K19230 GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008144,GO:0008150,GO:0008324,GO:0008519,GO:0009987,GO:0015075,GO:0015101,GO:0015203,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0017076,GO:0022857,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071804,GO:0071805,GO:0072488,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902047 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007509 389.0
TLS2_k127_5821584_3 FAD binding domain K05712,K16022,K20943,K20944 - 1.14.13.127,1.14.13.219,1.14.13.220 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006719 350.0
TLS2_k127_5821584_4 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 328.0
TLS2_k127_5821584_5 High confidence in function and specificity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004568 317.0
TLS2_k127_5821584_6 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001956 297.0
TLS2_k127_5821584_7 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000000000000000000000000000001017 228.0
TLS2_k127_5821584_8 Domain of unknown function (DUF3459) K01236 - 3.2.1.141 0.0005072 51.0
TLS2_k127_5833971_0 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 359.0
TLS2_k127_5833971_1 HAD-hyrolase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 300.0
TLS2_k127_5833971_2 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004423 247.0
TLS2_k127_5833971_3 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000008569 235.0
TLS2_k127_5833971_4 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.000000000000000000000000000000000000000000000001217 178.0
TLS2_k127_5833971_5 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.000000000000000000000000000000000000004499 166.0
TLS2_k127_5833971_6 ChaB - - - 0.00000000000000000000000000000000009243 145.0
TLS2_k127_5833971_7 nonspecific acid phosphatase - - - 0.000000000000000000000000000000005689 129.0
TLS2_k127_5833971_8 PFAM oxidoreductase domain protein - - - 0.000000000000000000007843 104.0
TLS2_k127_5833971_9 Protein of unknown function (DUF507) K09804 - - 0.0000000006324 66.0
TLS2_k127_5859466_0 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00169,K19070 GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 525.0
TLS2_k127_5859466_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004796 492.0
TLS2_k127_5859466_10 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001263 292.0
TLS2_k127_5859466_11 reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001592 275.0
TLS2_k127_5859466_12 Tripartite tricarboxylate transporter family receptor K07795 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004243 280.0
TLS2_k127_5859466_13 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001786 251.0
TLS2_k127_5859466_14 Glucose dehydrogenase C-terminus K00008,K00060 - 1.1.1.103,1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000001736 228.0
TLS2_k127_5859466_15 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000003609 237.0
TLS2_k127_5859466_16 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000279 219.0
TLS2_k127_5859466_17 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.000000000000000000000000000000000000000000000000000005837 209.0
TLS2_k127_5859466_18 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.00000000000000000000000000000000000000000000000001842 188.0
TLS2_k127_5859466_19 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000009225 156.0
TLS2_k127_5859466_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00170,K19071 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 481.0
TLS2_k127_5859466_20 Protein of unknown function (DUF2459) - - - 0.0000000000000000000000000000000000002066 149.0
TLS2_k127_5859466_21 dehydratase K17865 - 4.2.1.55 0.000000000000000000000000000000000003127 151.0
TLS2_k127_5859466_22 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.000000000000000000000000000000001402 145.0
TLS2_k127_5859466_23 MlaC protein K07323 - - 0.000000000000000000000000000001995 128.0
TLS2_k127_5859466_24 PFAM MaoC like domain - - - 0.00000000000000000000000000000218 137.0
TLS2_k127_5859466_25 Smr domain - - - 0.0000000000000000000000000001004 118.0
TLS2_k127_5859466_26 PFAM PHA accumulation regulator DNA-binding protein - - - 0.0000000000000000000000000004164 119.0
TLS2_k127_5859466_27 cyclic nucleotide binding K10914 - - 0.00000000000000000000007321 113.0
TLS2_k127_5859466_28 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000002008 108.0
TLS2_k127_5859466_29 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000007905 99.0
TLS2_k127_5859466_3 Domain of unknown function (DUF4445) K04755,K08952,K08953,K08954 GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006384 497.0
TLS2_k127_5859466_30 polyhydroxyalkanoic acid synthase, PhaR subunit - - - 0.00000001551 63.0
TLS2_k127_5859466_31 of the drug metabolite transporter (DMT) superfamily - - - 0.000001373 61.0
TLS2_k127_5859466_32 - - - - 0.0001056 49.0
TLS2_k127_5859466_4 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 484.0
TLS2_k127_5859466_5 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009178 414.0
TLS2_k127_5859466_6 Alanine-glyoxylate amino-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007417 373.0
TLS2_k127_5859466_7 Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (PorD-like) K00171 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009653 325.0
TLS2_k127_5859466_8 Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 324.0
TLS2_k127_5859466_9 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 288.0
TLS2_k127_589024_0 non-ribosomal peptide synthetase K02364 - 6.3.2.14 0.0 1840.0
TLS2_k127_589024_1 Acyl transferase domain in polyketide synthase (PKS) enzymes. - - - 0.0 1695.0
TLS2_k127_589024_2 Phosphopantetheine attachment site - - - 4.913e-223 722.0
TLS2_k127_589024_3 Glycosyl transferases group 1 - - - 0.0000000000000000000000003078 110.0
TLS2_k127_5928217_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004971 307.0
TLS2_k127_5928217_1 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 297.0
TLS2_k127_5928217_2 ABC-type polar amino acid transport system ATPase component K09972,K10004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004068 245.0
TLS2_k127_5928217_3 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000009966 214.0
TLS2_k127_5928217_4 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000136 195.0
TLS2_k127_5928217_5 zeta toxin - - - 0.0000000000000000000000000000000000000002096 163.0
TLS2_k127_5928217_6 - - - - 0.0000000000000000000000000000000000000006406 151.0
TLS2_k127_5928217_7 Glyoxalase-like domain K08234 - - 0.000000000000000000000000000000000002631 142.0
TLS2_k127_5928217_8 Sugar (and other) transporter - - - 0.00000000000000000000000000004734 132.0
TLS2_k127_6026171_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02652 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 1.569e-200 642.0
TLS2_k127_6026171_1 Type II secretion system (T2SS), protein F K02455,K02653 GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 376.0
TLS2_k127_6026171_10 Inosine-uridine preferring nucleoside hydrolase K01239,K01250 - 3.2.2.1 0.0000000000000000000000000000000000000005491 157.0
TLS2_k127_6026171_11 Isochorismatase family - - - 0.00000000000000000000000000000000001141 144.0
TLS2_k127_6026171_12 protein secretion K02460 - - 0.0000000000000000000000000005138 130.0
TLS2_k127_6026171_13 ECF sigma factor - - - 0.000000000000000000000001212 106.0
TLS2_k127_6026171_14 type IV pilus modification protein PilV K02458 - - 0.000000000006934 72.0
TLS2_k127_6026171_15 General secretion pathway protein H K02457 - - 0.00000000006725 73.0
TLS2_k127_6026171_16 Type II secretion system (T2SS), protein J K02459 - - 0.0000001394 63.0
TLS2_k127_6026171_17 Type II secretion system (T2SS), protein L K02461 - - 0.000002126 60.0
TLS2_k127_6026171_2 PFAM glycoside hydrolase, family 3 domain protein K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006608 280.0
TLS2_k127_6026171_3 Bacterial type II and III secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006144 295.0
TLS2_k127_6026171_4 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001294 269.0
TLS2_k127_6026171_5 BtpA family K06971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001618 254.0
TLS2_k127_6026171_6 PFAM Enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000002729 227.0
TLS2_k127_6026171_7 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00847,K00852 GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019303,GO:0019321,GO:0019323,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.15,2.7.1.4 0.000000000000000000000000000000000000000000000000000000000002927 228.0
TLS2_k127_6026171_8 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000472 183.0
TLS2_k127_6026171_9 Type II secretion system (T2SS), protein G K02456 - - 0.00000000000000000000000000000000000000001658 172.0
TLS2_k127_603759_0 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 482.0
TLS2_k127_603759_1 PFAM Extracellular ligand-binding receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 402.0
TLS2_k127_603759_2 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003885 355.0
TLS2_k127_603759_3 CoA-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 357.0
TLS2_k127_603759_4 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain K04940 - 1.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000001884 286.0
TLS2_k127_603759_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002694 285.0
TLS2_k127_603759_6 Abc transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006374 267.0
TLS2_k127_603759_7 amino acid K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005 258.0
TLS2_k127_603759_8 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001565 255.0
TLS2_k127_603759_9 acyl-CoA transferase carnitine dehydratase K18702 - 2.8.3.19 0.00000000000000000000000000000000000000000000000000000000000000000000004439 248.0
TLS2_k127_6057062_0 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 562.0
TLS2_k127_6057062_1 Aldo/keto reductase family K05275 - 1.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 439.0
TLS2_k127_6057062_10 HWE histidine kinase - - - 0.00000000000000000000000000000009378 144.0
TLS2_k127_6057062_11 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000005968 95.0
TLS2_k127_6057062_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 381.0
TLS2_k127_6057062_3 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000651 368.0
TLS2_k127_6057062_4 Tryptophan halogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 355.0
TLS2_k127_6057062_5 Belongs to the mandelate racemase muconate lactonizing enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007657 348.0
TLS2_k127_6057062_6 Histidine kinase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 344.0
TLS2_k127_6057062_7 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003556 249.0
TLS2_k127_6057062_8 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000001956 251.0
TLS2_k127_6057062_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000109 182.0
TLS2_k127_6062624_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1252.0
TLS2_k127_6062624_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 595.0
TLS2_k127_6062624_10 ABC transporter K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 301.0
TLS2_k127_6062624_11 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004489 273.0
TLS2_k127_6062624_12 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005252 274.0
TLS2_k127_6062624_13 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001248 264.0
TLS2_k127_6062624_14 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000007863 221.0
TLS2_k127_6062624_15 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000001297 205.0
TLS2_k127_6062624_16 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000001429 186.0
TLS2_k127_6062624_17 Protein of unknown function, DUF488 - - - 0.000000000000000001239 93.0
TLS2_k127_6062624_18 Biotin-lipoyl like K01960,K01965,K01968 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.1,6.4.1.3,6.4.1.4 0.000000000000000002113 96.0
TLS2_k127_6062624_19 His Kinase A (phosphoacceptor) domain K13924 - 2.1.1.80,3.1.1.61 0.0000000000000003718 87.0
TLS2_k127_6062624_2 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 551.0
TLS2_k127_6062624_20 PFAM alpha beta hydrolase fold K01055 - 3.1.1.24 0.000000000000002509 86.0
TLS2_k127_6062624_3 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K04105,K04110 - 6.2.1.25,6.2.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 492.0
TLS2_k127_6062624_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004571 425.0
TLS2_k127_6062624_5 SMP-30/Gluconolaconase/LRE-like region K01053,K02352 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 424.0
TLS2_k127_6062624_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007713 397.0
TLS2_k127_6062624_7 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 367.0
TLS2_k127_6062624_8 transport system periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 362.0
TLS2_k127_6062624_9 NMT1 THI5-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007516 339.0
TLS2_k127_6100048_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1068.0
TLS2_k127_6100048_1 acetyl-coa acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 561.0
TLS2_k127_6100048_10 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000000000000000000211 155.0
TLS2_k127_6100048_11 Domain of unknown function (DUF1932) - - - 0.0000000000000000000004675 103.0
TLS2_k127_6100048_12 - - - - 0.0000000000000000866 87.0
TLS2_k127_6100048_2 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008421 403.0
TLS2_k127_6100048_3 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006055 406.0
TLS2_k127_6100048_4 Sigma-54 interaction domain K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 404.0
TLS2_k127_6100048_5 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003715 261.0
TLS2_k127_6100048_6 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002502 241.0
TLS2_k127_6100048_7 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000000000008219 233.0
TLS2_k127_6100048_8 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000006528 200.0
TLS2_k127_6100048_9 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000000000000000003207 168.0
TLS2_k127_611169_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003196 311.0
TLS2_k127_611169_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 293.0
TLS2_k127_611169_2 CO dehydrogenase flavoprotein C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000001258 215.0
TLS2_k127_611169_3 Amidohydrolase family K01464 - 3.5.2.2 0.00000000000000000000000000000000000000000000000000000002005 204.0
TLS2_k127_611169_4 dehydrogenase small subunit K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000002577 185.0
TLS2_k127_611169_5 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.000000000007786 75.0
TLS2_k127_611169_6 Protein of unknown function DUF86 - - - 0.00000007658 55.0
TLS2_k127_6169295_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 3.079e-241 757.0
TLS2_k127_6169295_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 627.0
TLS2_k127_6169295_10 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 342.0
TLS2_k127_6169295_11 PFAM RNA binding S1 domain protein K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006858 340.0
TLS2_k127_6169295_12 PFAM amidohydrolase 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009623 339.0
TLS2_k127_6169295_13 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007734 284.0
TLS2_k127_6169295_14 PFAM sigma-54 factor interaction domain-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003716 282.0
TLS2_k127_6169295_15 hydrolase activity, acting on ester bonds K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000002307 254.0
TLS2_k127_6169295_17 PFAM Rhomboid family protein - - - 0.0000000000000000000000000000000000000001868 160.0
TLS2_k127_6169295_18 Glycine-zipper domain - - - 0.00000000000000000000000000001382 131.0
TLS2_k127_6169295_2 Isocitrate/isopropylmalate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 580.0
TLS2_k127_6169295_20 Macrocin-O-methyltransferase (TylF) - - - 0.0000000000000000000000002646 120.0
TLS2_k127_6169295_21 Redoxin - - - 0.0000000000001501 78.0
TLS2_k127_6169295_3 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 551.0
TLS2_k127_6169295_4 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 547.0
TLS2_k127_6169295_5 Histidine kinase K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006786 495.0
TLS2_k127_6169295_6 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005827 466.0
TLS2_k127_6169295_7 PFAM Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 410.0
TLS2_k127_6169295_8 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009119 446.0
TLS2_k127_6169295_9 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 362.0
TLS2_k127_6214264_0 4 iron, 4 sulfur cluster binding K00113,K00176,K05524,K13795,K13796 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008749 375.0
TLS2_k127_6214264_1 ABC 3 transport family K02075 - - 0.0000000000000000000000000000000000000000000000000000000000000000004413 248.0
TLS2_k127_6214264_2 Belongs to the bacterial solute-binding protein 9 family K02077,K09815 - - 0.0000000000000000000000000000000000000000000000000000000000001001 224.0
TLS2_k127_6214264_3 Urate oxidase N-terminal - - - 0.00000000000000000000000000000000000000000000003615 179.0
TLS2_k127_6214264_4 lactate metabolic process - - - 0.0000000000000000000000000000000000002021 158.0
TLS2_k127_6214264_5 phosphate-selective porin O and P - - - 0.0000000000000000000006174 106.0
TLS2_k127_6214264_6 Rubrerythrin - - - 0.000004367 48.0
TLS2_k127_6230258_0 Metallopeptidase family M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 603.0
TLS2_k127_6230258_1 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008624 416.0
TLS2_k127_6230258_2 AcrB/AcrD/AcrF family K03296 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 392.0
TLS2_k127_6230258_3 catechol 1,2-dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000001242 238.0
TLS2_k127_6230258_4 dehydratase - - - 0.0000000000000000000000000000000000000000000000766 176.0
TLS2_k127_6230258_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000006349 144.0
TLS2_k127_6230258_6 Endoribonuclease L-PSP - - - 0.000000000000000000000000000002739 136.0
TLS2_k127_6230258_7 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000002879 126.0
TLS2_k127_6230258_8 PFAM Hydantoinase B oxoprolinase K01469,K01474 - 3.5.2.14,3.5.2.9 0.00000000000004111 75.0
TLS2_k127_6274328_0 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 374.0
TLS2_k127_6274328_1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004697 369.0
TLS2_k127_6274328_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 356.0
TLS2_k127_6274328_3 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000227 279.0
TLS2_k127_6274328_4 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005593 246.0
TLS2_k127_6274328_5 MmgE PrpD family protein - - - 0.000000000000000000000000000000000000000000000000000001215 200.0
TLS2_k127_6274328_6 YsiA-like protein, C-terminal region K13770 - - 0.000000000000000000000000000000000000000001059 164.0
TLS2_k127_6274328_7 php family - - - 0.00000000000002383 84.0
TLS2_k127_6319163_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005013 470.0
TLS2_k127_6319163_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 394.0
TLS2_k127_6319163_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 389.0
TLS2_k127_6319163_3 Belongs to the UPF0271 (lamB) family K07160 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001626 279.0
TLS2_k127_6319163_4 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate K02437 - - 0.000000000000000000000000000000000000000000004513 166.0
TLS2_k127_6319163_5 PFAM Allophanate hydrolase subunit 2 - - - 0.0000000000000000000000000000000000000000004637 162.0
TLS2_k127_6319163_6 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.0000000000000000000000000000000000002058 158.0
TLS2_k127_6319163_7 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - 0.000000000000007886 81.0
TLS2_k127_6400020_0 Acyl-CoA dehydrogenase, N-terminal domain K00248,K00249,K18244 - 1.3.8.1,1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 551.0
TLS2_k127_6400020_1 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 381.0
TLS2_k127_6400020_2 HMGL-like K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 334.0
TLS2_k127_6400020_3 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001417 268.0
TLS2_k127_6400020_4 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000000004641 189.0
TLS2_k127_6400020_5 - - - - 0.000000000000000000000006429 113.0
TLS2_k127_6400020_6 O-Methyltransferase - - - 0.000000000000000000002527 103.0
TLS2_k127_6400020_7 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000001224 88.0
TLS2_k127_6404521_0 III protein, CoA-transferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 514.0
TLS2_k127_6404521_1 acyl-CoA dehydrogenase K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 479.0
TLS2_k127_6404521_10 ThiF family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004669 339.0
TLS2_k127_6404521_11 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 327.0
TLS2_k127_6404521_12 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 313.0
TLS2_k127_6404521_13 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000847 306.0
TLS2_k127_6404521_14 PFAM Alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 304.0
TLS2_k127_6404521_15 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002701 278.0
TLS2_k127_6404521_16 FAD binding domain K11472 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008321 278.0
TLS2_k127_6404521_17 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000004847 276.0
TLS2_k127_6404521_18 peptidyl-prolyl isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000001436 277.0
TLS2_k127_6404521_19 NMT1-like family K15553 - - 0.0000000000000000000000000000000000000000000000000000002419 207.0
TLS2_k127_6404521_2 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 483.0
TLS2_k127_6404521_20 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000003622 206.0
TLS2_k127_6404521_21 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000000000003503 184.0
TLS2_k127_6404521_22 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000004012 177.0
TLS2_k127_6404521_23 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000007008 191.0
TLS2_k127_6404521_24 dTDP-4-dehydrorhamnose 3,5-epimerase activity K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000008953 172.0
TLS2_k127_6404521_25 Involved in molybdopterin and thiamine biosynthesis, family 2 K03148,K21029,K21147 - 2.7.7.73,2.7.7.80,2.8.1.11 0.0000000000000000000000000003684 115.0
TLS2_k127_6404521_26 Histidine kinase - - - 0.0000000000000000000005277 106.0
TLS2_k127_6404521_27 Pfam 2OG-Fe(II) oxygenase - - - 0.0000000000000000000461 94.0
TLS2_k127_6404521_28 catechol 2,3-dioxygenase activity K07104 - 1.13.11.2 0.000000000000000001054 95.0
TLS2_k127_6404521_29 DNA-sulfur modification-associated - - - 0.0000000000000003554 91.0
TLS2_k127_6404521_3 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 440.0
TLS2_k127_6404521_30 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors - - - 0.0000001665 58.0
TLS2_k127_6404521_31 - - - - 0.0001966 52.0
TLS2_k127_6404521_4 PFAM FAD linked oxidase domain protein K00102,K00104 - 1.1.2.4,1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 443.0
TLS2_k127_6404521_5 FAD dependent oxidoreductase K00109,K15736 - 1.1.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 444.0
TLS2_k127_6404521_6 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007024 415.0
TLS2_k127_6404521_7 4fe-4S ferredoxin, iron-sulfur binding domain protein K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 416.0
TLS2_k127_6404521_8 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 397.0
TLS2_k127_6404521_9 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 370.0
TLS2_k127_6412430_0 Proton-conducting membrane transporter K00342,K05575 - 1.6.5.3 1.727e-198 654.0
TLS2_k127_6412430_1 NADH-quinone oxidoreductase chain L K00341,K05577 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 503.0
TLS2_k127_6412430_10 PFAM Phosphoribosyltransferase - - - 0.00000000000000000000000000000000000000992 158.0
TLS2_k127_6412430_11 FemAB family K05363,K11693 - 2.3.2.10,2.3.2.16 0.0000000000000000000000000000000000003517 155.0
TLS2_k127_6412430_12 Bacterial transcriptional repressor C-terminal K16137 - - 0.00000000000000000000000000000000004886 142.0
TLS2_k127_6412430_13 4Fe-4S dicluster domain K00338,K02573,K03941 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000139 141.0
TLS2_k127_6412430_14 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000001639 137.0
TLS2_k127_6412430_15 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000001927 133.0
TLS2_k127_6412430_16 Methicillin resistance protein K05363,K11693 - 2.3.2.10,2.3.2.16 0.00000000000000000000000000000003897 143.0
TLS2_k127_6412430_17 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000001021 116.0
TLS2_k127_6412430_18 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K00969,K09710 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 0.000000000000000000000000007379 119.0
TLS2_k127_6412430_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 - 1.6.5.3 0.00000000000000000000000001021 121.0
TLS2_k127_6412430_2 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009531 478.0
TLS2_k127_6412430_20 Tetratricopeptide repeat - - - 0.000000000000000000000001459 118.0
TLS2_k127_6412430_21 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000003377 107.0
TLS2_k127_6412430_22 Belongs to the complex I subunit 6 family K00339,K05578 - 1.6.5.3 0.00000000000000000000006293 106.0
TLS2_k127_6412430_23 Preprotein translocase SecG subunit K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000004474 89.0
TLS2_k127_6412430_24 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0004604 43.0
TLS2_k127_6412430_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006732 458.0
TLS2_k127_6412430_4 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 419.0
TLS2_k127_6412430_5 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 414.0
TLS2_k127_6412430_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343,K05573 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 428.0
TLS2_k127_6412430_7 PUA domain K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 376.0
TLS2_k127_6412430_8 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001463 275.0
TLS2_k127_6412430_9 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000004996 165.0
TLS2_k127_6448028_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 3.837e-223 706.0
TLS2_k127_6448028_1 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 514.0
TLS2_k127_6448028_10 Scavenger mRNA decapping enzyme C-term binding - - - 0.000000000000000000000000000000000000000009607 157.0
TLS2_k127_6448028_11 Major Facilitator Superfamily - - - 0.0000000000000000000000005379 119.0
TLS2_k127_6448028_12 Electron transfer flavoprotein K03521 - - 0.0001951 44.0
TLS2_k127_6448028_2 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003434 443.0
TLS2_k127_6448028_3 PFAM AMP-dependent synthetase and ligase K01897,K01911 - 6.2.1.26,6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003533 439.0
TLS2_k127_6448028_4 Dehydrogenase K00248,K11410,K18244 GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681 1.3.8.1,1.3.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 421.0
TLS2_k127_6448028_5 electron transfer flavoprotein, alpha subunit K03522,K22432 - 1.3.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 293.0
TLS2_k127_6448028_6 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004541 251.0
TLS2_k127_6448028_7 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008258 247.0
TLS2_k127_6448028_8 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000007194 252.0
TLS2_k127_6448028_9 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000001382 206.0
TLS2_k127_6529009_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 6.156e-271 844.0
TLS2_k127_6529009_1 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 7.725e-206 653.0
TLS2_k127_6529009_10 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001331 278.0
TLS2_k127_6529009_11 Short chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000164 202.0
TLS2_k127_6529009_12 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000002847 185.0
TLS2_k127_6529009_13 Transcription factor zinc-finger - - - 0.0000000000000000000000000000000000000000001587 174.0
TLS2_k127_6529009_14 PFAM Patatin - - - 0.0000000000000000000000000000000000000000071 168.0
TLS2_k127_6529009_15 Carboxymuconolactone decarboxylase family - - - 0.00000000003225 67.0
TLS2_k127_6529009_16 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000624 65.0
TLS2_k127_6529009_17 Adenylate - - - 0.00000009963 63.0
TLS2_k127_6529009_2 PFAM AMP-dependent synthetase and ligase - - - 3.636e-198 634.0
TLS2_k127_6529009_3 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 436.0
TLS2_k127_6529009_4 transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004389 395.0
TLS2_k127_6529009_5 FMN-dependent dehydrogenase K00101,K15054,K16422 - 1.1.2.3,1.1.3.46,1.1.99.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 380.0
TLS2_k127_6529009_6 Pirin K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 346.0
TLS2_k127_6529009_7 acyl-CoA transferases carnitine dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 341.0
TLS2_k127_6529009_8 MmgE PrpD family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 300.0
TLS2_k127_6529009_9 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003258 277.0
TLS2_k127_6558481_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1196.0
TLS2_k127_6558481_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000003871 214.0
TLS2_k127_6558481_2 Sigma-54 interaction domain - - - 0.00000000000000000002734 94.0
TLS2_k127_6558481_3 MmgE PrpD family protein - - - 0.00005706 49.0
TLS2_k127_6558481_4 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. - - - 0.000123 48.0
TLS2_k127_6609686_0 Glycosyltransferase family 20 - - - 7.882e-211 683.0
TLS2_k127_6609686_1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 327.0
TLS2_k127_6609686_2 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006105 321.0
TLS2_k127_6609686_3 PFAM phosphoesterase, RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006398 319.0
TLS2_k127_6609686_4 ubiE/COQ5 methyltransferase family K00570 - 2.1.1.17,2.1.1.71 0.00000000000000000001541 93.0
TLS2_k127_6616729_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 369.0
TLS2_k127_6616729_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 354.0
TLS2_k127_6616729_2 ABC transporter permease K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 317.0
TLS2_k127_6616729_3 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 309.0
TLS2_k127_6616729_4 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919,K16924 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.0000000000000000000000000000000000000000000000000000002456 205.0
TLS2_k127_6616729_5 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - 0.00004741 51.0
TLS2_k127_6616729_6 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00011 53.0
TLS2_k127_6665726_0 xanthine dehydrogenase activity K04108 - 1.3.7.9 1.487e-320 1007.0
TLS2_k127_6665726_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 578.0
TLS2_k127_6665726_10 cob(I)yrinic acid a,c-diamide adenosyltransferase activity K00798,K13821 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.2.1.88,1.5.5.2,2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000009292 216.0
TLS2_k127_6665726_11 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000008069 147.0
TLS2_k127_6665726_12 Enoyl-CoA hydratase/isomerase K16880 - - 0.0000000000000000000000000000000004247 134.0
TLS2_k127_6665726_13 sequence-specific DNA binding - - - 0.00000002042 65.0
TLS2_k127_6665726_2 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 506.0
TLS2_k127_6665726_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 473.0
TLS2_k127_6665726_4 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007718 374.0
TLS2_k127_6665726_5 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 370.0
TLS2_k127_6665726_6 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008668 285.0
TLS2_k127_6665726_7 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000001677 245.0
TLS2_k127_6665726_8 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000001528 236.0
TLS2_k127_6665726_9 2Fe-2S -binding domain protein K03518,K07302,K19819 - 1.2.5.3,1.3.99.16,1.5.99.4 0.00000000000000000000000000000000000000000000000000000000000006561 217.0
TLS2_k127_6666277_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 0.0 1125.0
TLS2_k127_6666277_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.796e-217 694.0
TLS2_k127_6666277_10 Ribonuclease, BN K07058 - - 0.00000001196 67.0
TLS2_k127_6666277_2 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004802 594.0
TLS2_k127_6666277_3 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042,K17468 - 2.9.1.1,4.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 443.0
TLS2_k127_6666277_4 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002846 436.0
TLS2_k127_6666277_5 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004307 284.0
TLS2_k127_6666277_6 Protein of unknown function (DUF3105) - - - 0.000000000000000000000000000000000000000001843 161.0
TLS2_k127_6666277_7 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000002093 132.0
TLS2_k127_6666277_8 gag-polyprotein putative aspartyl protease - - - 0.000000000000004872 85.0
TLS2_k127_6666277_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000001631 66.0
TLS2_k127_6670717_0 ABC transporter transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 384.0
TLS2_k127_6670717_1 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000001368 177.0
TLS2_k127_6670717_2 - - - - 0.000000000000000000002105 111.0
TLS2_k127_6670717_3 NADP-dependent oxidoreductases - - - 0.00000000002573 71.0
TLS2_k127_6670717_4 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 0.00000000002951 63.0
TLS2_k127_6670717_5 alcohol dehydrogenase K07119 - - 0.0000007086 58.0
TLS2_k127_6670717_6 Putative restriction endonuclease - - - 0.0001533 51.0
TLS2_k127_6670717_7 HEAT repeat - - - 0.0009561 48.0
TLS2_k127_6685950_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.207e-247 776.0
TLS2_k127_6685950_1 General secretory system II protein E domain protein - - - 2.17e-245 780.0
TLS2_k127_6685950_10 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000001996 173.0
TLS2_k127_6685950_11 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000002387 174.0
TLS2_k127_6685950_12 Binding-protein-dependent transport system inner membrane component K11070 - - 0.00000000000000000000000000000000000000000000155 185.0
TLS2_k127_6685950_13 Protein of unknown function (DUF3225) - - - 0.000000000000000000000000000000000000000001101 177.0
TLS2_k127_6685950_14 - - - - 0.00000000000000000000000000000000000000002986 164.0
TLS2_k127_6685950_15 Spermidine putrescine ABC transporter, substrate-binding protein K11069 - - 0.00000000000000000000000000000000007233 148.0
TLS2_k127_6685950_16 arylformamidase activity - - - 0.0000000000000000000000000004198 125.0
TLS2_k127_6685950_17 Cro/C1-type HTH DNA-binding domain - - - 0.00000000000000001955 86.0
TLS2_k127_6685950_18 Two component, sigma54 specific, transcriptional regulator, Fis family K07712,K07714 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.00000000001104 68.0
TLS2_k127_6685950_19 Protein of unknown function (DUF4089) - - - 0.00001253 53.0
TLS2_k127_6685950_2 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 600.0
TLS2_k127_6685950_3 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003657 567.0
TLS2_k127_6685950_4 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004632 554.0
TLS2_k127_6685950_5 Glycosyltransferase like family 2 K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 421.0
TLS2_k127_6685950_6 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005749 378.0
TLS2_k127_6685950_7 Sugar (and other) transporter K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009973 328.0
TLS2_k127_6685950_8 Putrescine transport system permease - - - 0.0000000000000000000000000000000000000000000000000000000000005463 234.0
TLS2_k127_6685950_9 COG2185 Methylmalonyl-CoA mutase, C-terminal domain subunit (cobalamin-binding) K01849,K20907 - 5.4.99.2,5.4.99.64 0.0000000000000000000000000000000000000000000000003669 181.0
TLS2_k127_6702346_0 Pyruvate ferredoxin/flavodoxin oxidoreductase K00179,K04090 - 1.2.7.8 0.0 1229.0
TLS2_k127_6702346_1 PFAM Fibronectin type III domain - - - 0.000000000006598 80.0
TLS2_k127_6728219_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1162.0
TLS2_k127_6728219_1 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 1.23e-303 959.0
TLS2_k127_6728219_10 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001921 298.0
TLS2_k127_6728219_11 Transglycosylase SLT domain K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002344 281.0
TLS2_k127_6728219_12 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000001811 246.0
TLS2_k127_6728219_13 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000005179 255.0
TLS2_k127_6728219_14 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000001023 225.0
TLS2_k127_6728219_15 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000000269 213.0
TLS2_k127_6728219_16 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000001597 205.0
TLS2_k127_6728219_17 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000002652 205.0
TLS2_k127_6728219_18 NIPSNAP - - - 0.000000000000000000000000000000000000000000127 167.0
TLS2_k127_6728219_2 PFAM amidohydrolase K07045 - - 1.552e-201 636.0
TLS2_k127_6728219_20 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000001783 157.0
TLS2_k127_6728219_21 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000001013 152.0
TLS2_k127_6728219_22 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000002652 113.0
TLS2_k127_6728219_23 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00002946 51.0
TLS2_k127_6728219_3 Berberine and berberine like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 483.0
TLS2_k127_6728219_4 DegT/DnrJ/EryC1/StrS aminotransferase family K04127 - 5.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 507.0
TLS2_k127_6728219_5 F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 424.0
TLS2_k127_6728219_6 Belongs to the amidase family K01426,K19795 - 3.5.1.4,3.5.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 432.0
TLS2_k127_6728219_7 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 406.0
TLS2_k127_6728219_8 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 394.0
TLS2_k127_6728219_9 Protein of unknown function (DUF3500) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005048 309.0
TLS2_k127_6730850_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007966 555.0
TLS2_k127_6730850_1 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 508.0
TLS2_k127_6730850_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005482 390.0
TLS2_k127_6730850_3 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004276 285.0
TLS2_k127_6730850_4 ankyrin repeat K06867,K15503 - - 0.000000000000000000000000000000000000000000000000000000000000000000002809 252.0
TLS2_k127_6730850_5 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000000000000001967 229.0
TLS2_k127_6730850_6 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000008785 179.0
TLS2_k127_6730850_7 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000002782 167.0
TLS2_k127_6730850_8 Putative cyclase - - - 0.000000000000000000000000000000000004262 142.0
TLS2_k127_6732842_0 branched-chain amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 470.0
TLS2_k127_6732842_1 Amidohydrolase family K01464 - 3.5.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 451.0
TLS2_k127_6732842_2 PFAM ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006475 278.0
TLS2_k127_6732842_3 Receptor family ligand binding region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002417 289.0
TLS2_k127_6732842_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001683 271.0
TLS2_k127_6732842_5 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003481 259.0
TLS2_k127_6732842_6 Metal-binding integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001189 256.0
TLS2_k127_6732842_7 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001346 257.0
TLS2_k127_6732842_8 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003256 259.0
TLS2_k127_6732842_9 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000002686 100.0
TLS2_k127_6757686_0 Putative amidoligase enzyme (DUF2126) - - - 0.0 1523.0
TLS2_k127_6757686_1 Circularly permuted ATP-grasp type 2 - - - 1.77e-214 712.0
TLS2_k127_6757686_2 SNARE associated Golgi protein - - - 0.000000000000000007538 86.0
TLS2_k127_6757686_3 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000002804 64.0
TLS2_k127_6797117_0 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 608.0
TLS2_k127_6797117_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 524.0
TLS2_k127_6797117_10 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000001133 223.0
TLS2_k127_6797117_11 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0000000000000000000000000000000000000000000000000005292 192.0
TLS2_k127_6797117_12 Na H antiporter K05566 - - 0.00000000000000000000000000000000004308 145.0
TLS2_k127_6797117_13 Na+/H+ ion antiporter subunit K05569 - - 0.0000000000000000000000000000002721 137.0
TLS2_k127_6797117_14 PFAM NADH-ubiquinone oxidoreductase chain 4L K05567 - - 0.000000000000000000000000000006604 129.0
TLS2_k127_6797117_15 Domain related to MnhB subunit of Na+/H+ antiporter - - - 0.00000000000000000000000002588 123.0
TLS2_k127_6797117_16 RNA recognition motif - - - 0.000000000000000000000002111 108.0
TLS2_k127_6797117_17 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.0000000000000000001372 96.0
TLS2_k127_6797117_18 Pfam Multiple resistance and pH regulation protein F K05570 - - 0.0000000000000000004638 96.0
TLS2_k127_6797117_19 Domain of unknown function (DUF4212) K14393 - - 0.000000000001319 79.0
TLS2_k127_6797117_2 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 477.0
TLS2_k127_6797117_20 aspartic-type endopeptidase activity - - - 0.00000000000244 76.0
TLS2_k127_6797117_3 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008026 456.0
TLS2_k127_6797117_4 CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007159 396.0
TLS2_k127_6797117_5 PFAM sigma-54 factor interaction domain-containing protein K02481,K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003788 409.0
TLS2_k127_6797117_6 PFAM NADH Ubiquinone plastoquinone (complex I) K05568,K12141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 383.0
TLS2_k127_6797117_7 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004382 280.0
TLS2_k127_6797117_8 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000002568 271.0
TLS2_k127_6797117_9 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006864 270.0
TLS2_k127_6812556_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 5.965e-286 900.0
TLS2_k127_6812556_1 Aconitase C-terminal domain K01681 - 4.2.1.3 1.044e-221 704.0
TLS2_k127_6812556_10 Protein of unknown function (DUF1722) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 362.0
TLS2_k127_6812556_11 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 329.0
TLS2_k127_6812556_12 Mur ligase middle domain protein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 323.0
TLS2_k127_6812556_13 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 306.0
TLS2_k127_6812556_14 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 308.0
TLS2_k127_6812556_15 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 321.0
TLS2_k127_6812556_16 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 301.0
TLS2_k127_6812556_17 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008705 284.0
TLS2_k127_6812556_18 Belongs to the LDH2 MDH2 oxidoreductase family K00073,K13574 - 1.1.1.350 0.00000000000000000000000000000000000000000000000000000000000000000000000001283 263.0
TLS2_k127_6812556_19 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000111 258.0
TLS2_k127_6812556_2 Belongs to the TPP enzyme family K01576 - 4.1.1.7 1.714e-206 676.0
TLS2_k127_6812556_20 SIS domain K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000000000003517 244.0
TLS2_k127_6812556_21 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000006383 242.0
TLS2_k127_6812556_22 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000284 244.0
TLS2_k127_6812556_23 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000455 224.0
TLS2_k127_6812556_24 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000001242 239.0
TLS2_k127_6812556_25 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000004306 223.0
TLS2_k127_6812556_26 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000008082 231.0
TLS2_k127_6812556_27 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000006613 214.0
TLS2_k127_6812556_28 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000004832 183.0
TLS2_k127_6812556_29 Sterol carrier protein - - - 0.000000000000000000000000000000000000000001446 160.0
TLS2_k127_6812556_3 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 438.0
TLS2_k127_6812556_30 Belongs to the enoyl-CoA hydratase isomerase family K01692,K01715,K15866,K20036 - 4.2.1.155,4.2.1.17,5.3.3.18 0.0000000000000000000000000000000000000001012 169.0
TLS2_k127_6812556_31 MlaC protein K07323 - - 0.0000000000000000000000000000001573 139.0
TLS2_k127_6812556_32 Endoribonuclease L-PSP - - - 0.000000000000000000000000000008485 139.0
TLS2_k127_6812556_33 Thioredoxin-like K02199 - - 0.000000000000000000000000005774 118.0
TLS2_k127_6812556_34 FCD - - - 0.000000000000000000000000008256 119.0
TLS2_k127_6812556_35 diguanylate cyclase - - - 0.00000000000000001131 98.0
TLS2_k127_6812556_36 BadF/BadG/BcrA/BcrD ATPase family - - - 0.00000000000001717 86.0
TLS2_k127_6812556_38 - - - - 0.0000008491 62.0
TLS2_k127_6812556_4 protoporphyrinogen oxidase activity K00231,K14266 - 1.14.19.9,1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 434.0
TLS2_k127_6812556_5 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K01719,K13542 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,4.1.1.37,4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 456.0
TLS2_k127_6812556_6 PFAM 4-hydroxyphenylacetate 3-hydroxylase K00483 - 1.14.14.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 424.0
TLS2_k127_6812556_7 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003576 404.0
TLS2_k127_6812556_8 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003245 398.0
TLS2_k127_6812556_9 PrpF protein K09788 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006609 372.0
TLS2_k127_686098_0 His Kinase A (phosphoacceptor) domain - - - 0.0 1135.0
TLS2_k127_686098_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006072 525.0
TLS2_k127_686098_2 PFAM amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 313.0
TLS2_k127_686098_3 B3/4 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005005 307.0
TLS2_k127_686098_4 Class ii aldolase K01628,K03077 - 4.1.2.17,5.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000001568 230.0
TLS2_k127_686098_5 PFAM FAD dependent oxidoreductase K00285 - 1.4.5.1 0.000000000000000000000000000000009319 131.0
TLS2_k127_6882391_0 Surface antigen K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005914 504.0
TLS2_k127_6882391_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004916 424.0
TLS2_k127_6882391_10 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000009135 247.0
TLS2_k127_6882391_11 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000000001975 237.0
TLS2_k127_6882391_12 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000001676 233.0
TLS2_k127_6882391_13 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000183 225.0
TLS2_k127_6882391_14 D,d-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000000000000000007194 216.0
TLS2_k127_6882391_15 Cytidylate kinase K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000449 209.0
TLS2_k127_6882391_16 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000007708 211.0
TLS2_k127_6882391_17 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02841,K02843,K02849,K12982 - - 0.0000000000000000000000000000000000000000000000000902 192.0
TLS2_k127_6882391_18 PFAM Glycosyl transferase, group 1 K02844 - - 0.0000000000000000000000000000000000000000000000097 191.0
TLS2_k127_6882391_19 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000008586 163.0
TLS2_k127_6882391_2 TIGRFAM tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 394.0
TLS2_k127_6882391_20 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.00000000000000000000000000000000000000004585 166.0
TLS2_k127_6882391_21 D,D-heptose 1,7-bisphosphate phosphatase K02841,K02843,K02849,K03271,K03272,K03273 - 2.7.1.167,2.7.7.70,3.1.3.82,3.1.3.83,5.3.1.28 0.000000000000000000000000000000000000001301 165.0
TLS2_k127_6882391_22 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.00000000000000000000000000000000000000174 161.0
TLS2_k127_6882391_23 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000001877 166.0
TLS2_k127_6882391_24 Belongs to the ClpA ClpB family K03696 GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - 0.0000000000000000000000000000000000013 142.0
TLS2_k127_6882391_25 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000003781 147.0
TLS2_k127_6882391_26 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000005657 148.0
TLS2_k127_6882391_27 Domain of unknown function (DUF374) K09778 - - 0.0000000000000000000000000000000427 135.0
TLS2_k127_6882391_28 Psort location Cytoplasmic, score 8.96 K09949 - - 0.00000000000000000000000859 117.0
TLS2_k127_6882391_29 Outer membrane protein (OmpH-like) K06142 - - 0.00000000000000000001153 100.0
TLS2_k127_6882391_3 Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 381.0
TLS2_k127_6882391_4 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 378.0
TLS2_k127_6882391_5 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007335 334.0
TLS2_k127_6882391_6 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002062 299.0
TLS2_k127_6882391_7 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000001572 276.0
TLS2_k127_6882391_8 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000002182 270.0
TLS2_k127_6882391_9 inositol 2-dehydrogenase activity K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008724 264.0
TLS2_k127_6948277_0 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009795 585.0
TLS2_k127_6948277_1 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 325.0
TLS2_k127_6948277_2 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000003697 235.0
TLS2_k127_6948277_3 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000004392 221.0
TLS2_k127_6948277_4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.00000000000000000000000000000000000000000000000000000589 195.0
TLS2_k127_6948277_5 Cytochrome c - - - 0.0000000000000000000000000549 126.0
TLS2_k127_6948277_6 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000005315 96.0
TLS2_k127_699911_0 Luciferase-like monooxygenase - - - 3.779e-207 649.0
TLS2_k127_699911_1 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 590.0
TLS2_k127_699911_10 OsmC-like protein - - - 0.00000000000000000000000000000000001222 150.0
TLS2_k127_699911_2 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007932 358.0
TLS2_k127_699911_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006399 348.0
TLS2_k127_699911_4 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 332.0
TLS2_k127_699911_5 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004473 330.0
TLS2_k127_699911_6 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002756 290.0
TLS2_k127_699911_7 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006613 263.0
TLS2_k127_699911_8 Alcohol dehydrogenase zinc-binding domain protein K13953,K18382 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000002174 260.0
TLS2_k127_699911_9 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000003209 146.0
TLS2_k127_7007208_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 324.0
TLS2_k127_7007208_1 Belongs to the mandelate racemase muconate lactonizing enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 314.0
TLS2_k127_7007208_2 membrane - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 308.0
TLS2_k127_7007208_3 Periplasmic binding protein - - - 0.00000000000000000000000000000000000000000000000000000000008643 214.0
TLS2_k127_7007208_4 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00850,K00895,K21071 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000001534 182.0
TLS2_k127_7007208_5 endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000000001813 184.0
TLS2_k127_7007208_6 Hydrolase - - - 0.000000000000000000000000000000000000000000007435 173.0
TLS2_k127_7062108_0 PKS_DH - - - 0.0 1869.0
TLS2_k127_7062108_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 3.384e-225 706.0
TLS2_k127_7062108_10 Transcriptional regulator - - - 0.00003019 55.0
TLS2_k127_7062108_11 Belongs to the chaperonin (HSP60) family K04077 - - 0.00006322 51.0
TLS2_k127_7062108_2 ADP-ribosylglycohydrolase - - - 0.00000000000000000000000000000000000000000000000000003636 201.0
TLS2_k127_7062108_3 PFAM Transposase IS116 IS110 IS902 family, Transposase - - - 0.0000000000000000000000000000000000000000000001154 188.0
TLS2_k127_7062108_4 Nicotinamidase K08281 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.1.19 0.000000000000000000000000000000000012 139.0
TLS2_k127_7062108_5 Isochorismatase family K08281 - 3.5.1.19 0.000000000000000002024 100.0
TLS2_k127_7062108_6 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 0.000000000000001636 85.0
TLS2_k127_7062108_7 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.000000000005588 72.0
TLS2_k127_7062108_8 Belongs to the P-Pant transferase superfamily K06133 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.0000004275 60.0
TLS2_k127_7062108_9 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.000001445 63.0
TLS2_k127_7088993_0 Two component, sigma54 specific, transcriptional regulator, Fis family K07714,K19641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 414.0
TLS2_k127_7088993_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006556 272.0
TLS2_k127_7088993_2 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000003697 190.0
TLS2_k127_7088993_3 O-Antigen ligase - - - 0.00000000000000000134 100.0
TLS2_k127_7088993_4 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.00000000000000001761 98.0
TLS2_k127_7088993_5 TIGRFAM FemAB-related protein, PEP-CTERM - - - 0.000000002355 63.0
TLS2_k127_7088993_6 Bacterial Ig-like domain 2 - - - 0.00000652 60.0
TLS2_k127_710820_0 AAA ATPase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009164 619.0
TLS2_k127_710820_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 483.0
TLS2_k127_710820_11 acetyltransferase K03823 - 2.3.1.183 0.000000000000000000000000000543 123.0
TLS2_k127_710820_12 Tetratricopeptide repeat - - - 0.00000000000000000001036 109.0
TLS2_k127_710820_13 SNARE associated Golgi protein - - - 0.000000000000000003512 94.0
TLS2_k127_710820_14 serine-type endopeptidase activity K20276 - - 0.000000000002968 79.0
TLS2_k127_710820_15 Methylmuconolactone methyl-isomerase - - - 0.00000000709 64.0
TLS2_k127_710820_16 Transport of potassium into the cell K03549 - - 0.00001472 57.0
TLS2_k127_710820_17 Carboxypeptidase regulatory-like domain - - - 0.00005132 56.0
TLS2_k127_710820_2 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 475.0
TLS2_k127_710820_3 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000974 383.0
TLS2_k127_710820_4 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 362.0
TLS2_k127_710820_5 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 344.0
TLS2_k127_710820_6 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001214 289.0
TLS2_k127_710820_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002701 284.0
TLS2_k127_710820_8 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001851 252.0
TLS2_k127_710820_9 Protein of unknown function (DUF429) - - - 0.000000000000000000000000000000002195 149.0
TLS2_k127_7145320_0 PFAM amidohydrolase K01464,K01465 - 3.5.2.2,3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006383 589.0
TLS2_k127_7145320_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 500.0
TLS2_k127_7145320_2 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 408.0
TLS2_k127_7145320_3 trans-aconitate K00598 - 2.1.1.144 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 328.0
TLS2_k127_7145320_4 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 327.0
TLS2_k127_7145320_5 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002119 264.0
TLS2_k127_7145320_6 Putative restriction endonuclease - - - 0.000000000000000000000000000000000001447 145.0
TLS2_k127_7145320_7 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 0.000000000000000000000007341 103.0
TLS2_k127_7145320_8 - - - - 0.000000000008008 68.0
TLS2_k127_7145320_9 - - - - 0.00008614 55.0
TLS2_k127_7148861_0 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K09461 - 1.14.13.40 0.0 1139.0
TLS2_k127_7148861_1 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000657 327.0
TLS2_k127_7148861_10 Single Cache domain 2 K02480 - 2.7.13.3 0.0006152 53.0
TLS2_k127_7148861_2 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 300.0
TLS2_k127_7148861_3 gluconolactonase K01053,K14274 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002392 280.0
TLS2_k127_7148861_4 COG4177 ABC-type branched-chain amino acid transport system, permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003571 284.0
TLS2_k127_7148861_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001227 265.0
TLS2_k127_7148861_6 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007221 260.0
TLS2_k127_7148861_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001114 257.0
TLS2_k127_7148861_8 Single Cache domain 2 K02480 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000004431 222.0
TLS2_k127_7229807_0 formamidase K01455 - 3.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004073 492.0
TLS2_k127_7229807_1 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 420.0
TLS2_k127_7229807_2 BON domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002322 237.0
TLS2_k127_7229807_3 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000001763 238.0
TLS2_k127_7229807_4 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000001192 205.0
TLS2_k127_7229807_5 DoxX K15977 - - 0.00000000000000000000000000000000000000000000000554 180.0
TLS2_k127_7229807_6 Tryptophan-rich sensory protein K05770 - - 0.0000000000000000000000000000000000000000005287 169.0
TLS2_k127_7229807_7 PFAM Glyoxalase bleomycin resistance protein dioxygenase K01759,K05606 - 4.4.1.5,5.1.99.1 0.0000000000000000006188 91.0
TLS2_k127_7229807_8 cytochrome p450 - - - 0.00000000000000003442 92.0
TLS2_k127_7229807_9 periplasmic or secreted lipoprotein - - - 0.0005415 49.0
TLS2_k127_7232817_0 Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009014 443.0
TLS2_k127_7232817_1 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005806 404.0
TLS2_k127_7232817_10 Two component signalling adaptor domain K02487,K06596 - - 0.000000000884 66.0
TLS2_k127_7232817_2 COG2513 PEP phosphonomutase and related enzymes K01637 GO:0003674,GO:0003824,GO:0004451,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046487,GO:0071704 4.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 333.0
TLS2_k127_7232817_3 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000001804 200.0
TLS2_k127_7232817_4 Competence-damaged protein - - - 0.0000000000000000000000000000000000000000000000000008557 205.0
TLS2_k127_7232817_5 COGs COG4636 conserved - - - 0.00000000000000000000000000000000000005598 157.0
TLS2_k127_7232817_6 - - - - 0.0000000000000000000000000002477 122.0
TLS2_k127_7232817_7 Major Facilitator Superfamily - - - 0.000000000000000000000000004441 126.0
TLS2_k127_7232817_8 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000003334 117.0
TLS2_k127_7232817_9 CHASE2 K01768 - 4.6.1.1 0.0000000000002766 79.0
TLS2_k127_7242304_0 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 509.0
TLS2_k127_7242304_1 transport system, fused permease components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 466.0
TLS2_k127_7242304_2 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001875 278.0
TLS2_k127_7242304_3 ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002127 257.0
TLS2_k127_7242304_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001323 257.0
TLS2_k127_7242304_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000007786 244.0
TLS2_k127_7270388_0 - - - - 1.005e-313 970.0
TLS2_k127_7270388_1 L-lactate dehydrogenase K00101,K16422 - 1.1.2.3,1.1.3.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 447.0
TLS2_k127_7270388_2 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 332.0
TLS2_k127_7270388_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000008375 227.0
TLS2_k127_7270388_4 PFAM Phosphoglycerate mutase - - - 0.00000000000000000000000000000000000000003149 170.0
TLS2_k127_7270388_5 PFAM N-formylglutamate amidohydrolase - - - 0.00000000000000000007538 101.0
TLS2_k127_7270388_6 EamA-like transporter family - - - 0.000000000000006621 85.0
TLS2_k127_7278833_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 595.0
TLS2_k127_7278833_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000505 537.0
TLS2_k127_7278833_10 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000003436 239.0
TLS2_k127_7278833_11 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000001484 229.0
TLS2_k127_7278833_12 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.000000000000000000000000000000000000001999 161.0
TLS2_k127_7278833_13 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000005641 113.0
TLS2_k127_7278833_14 Ferredoxin - - - 0.0000000000000000000006731 102.0
TLS2_k127_7278833_2 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007243 398.0
TLS2_k127_7278833_3 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 396.0
TLS2_k127_7278833_4 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 369.0
TLS2_k127_7278833_5 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 338.0
TLS2_k127_7278833_6 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 338.0
TLS2_k127_7278833_7 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 316.0
TLS2_k127_7278833_8 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003828 281.0
TLS2_k127_7278833_9 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000166 299.0
TLS2_k127_7281698_0 Adenylate and Guanylate cyclase catalytic domain - - - 5.713e-274 882.0
TLS2_k127_7281698_1 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000006814 235.0
TLS2_k127_7281698_2 Pfam:Pyridox_oxidase - - - 0.000000000000000000000000000122 115.0
TLS2_k127_7281698_3 - - - - 0.000000000000000001439 98.0
TLS2_k127_7281698_4 Thermolysin metallopeptidase, catalytic domain K01400,K01401,K19351 GO:0005575,GO:0005576 3.4.24.28,3.4.24.29 0.0000001316 66.0
TLS2_k127_730967_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 8.082e-261 825.0
TLS2_k127_730967_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 6.325e-194 617.0
TLS2_k127_730967_10 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000002264 248.0
TLS2_k127_730967_11 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000001832 250.0
TLS2_k127_730967_12 PAS domain - - - 0.0000000000000000000000000000000000000000000000003437 192.0
TLS2_k127_730967_13 Two component transcriptional regulator, LuxR family K07695 - - 0.00000000000000000000000000000000000000001412 163.0
TLS2_k127_730967_14 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000004523 153.0
TLS2_k127_730967_15 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000002625 99.0
TLS2_k127_730967_16 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000001114 93.0
TLS2_k127_730967_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009043 539.0
TLS2_k127_730967_3 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 462.0
TLS2_k127_730967_4 Belongs to the peptidase M16 family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 409.0
TLS2_k127_730967_5 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 301.0
TLS2_k127_730967_6 PFAM SAICAR synthetase K01756,K01923 - 4.3.2.2,6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 294.0
TLS2_k127_730967_7 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009761 301.0
TLS2_k127_730967_8 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885,K15977 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001751 287.0
TLS2_k127_730967_9 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001196 262.0
TLS2_k127_7338431_0 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000006864 239.0
TLS2_k127_7338431_10 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.00007309 55.0
TLS2_k127_7338431_2 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000008503 187.0
TLS2_k127_7338431_4 FKBP-type peptidyl-prolyl cis-trans isomerase K03775 - 5.2.1.8 0.000000000000000000000000000000000000003498 150.0
TLS2_k127_7338431_5 PFAM Lytic transglycosylase catalytic K08309 - - 0.00000000000000000000000000000009172 137.0
TLS2_k127_7338431_6 DNA-binding transcription factor activity K03710 - - 0.0000000000000000000000000000004648 132.0
TLS2_k127_7338431_7 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.00000000000000000000000000004408 130.0
TLS2_k127_7338431_8 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.00000000000000000000000003473 117.0
TLS2_k127_7338431_9 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000006027 108.0
TLS2_k127_7339816_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 450.0
TLS2_k127_7339816_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 422.0
TLS2_k127_7339816_10 glycosyl transferase - - - 0.0000000000000000000000000000000000000000000001594 186.0
TLS2_k127_7339816_11 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000000000415 130.0
TLS2_k127_7339816_12 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000000000000009755 132.0
TLS2_k127_7339816_13 PFAM Glycosyl transferase, family 39 - - - 0.000000000000000000000000001006 128.0
TLS2_k127_7339816_15 YbbR-like protein - - - 0.00000000000000000000006685 107.0
TLS2_k127_7339816_16 EamA-like transporter family - - - 0.00000000000000000002745 102.0
TLS2_k127_7339816_17 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000007128 87.0
TLS2_k127_7339816_18 Beta-ketoacyl synthase, C-terminal domain K09458,K11609 - 2.3.1.179 0.0000000000001413 82.0
TLS2_k127_7339816_19 Phosphopantetheine attachment site K02078 - - 0.0000126 52.0
TLS2_k127_7339816_2 Belongs to the beta-ketoacyl-ACP synthases family K05551,K09458 - 2.3.1.179,2.3.1.235,2.3.1.260 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 300.0
TLS2_k127_7339816_20 synthase K09458 - 2.3.1.179 0.00001911 58.0
TLS2_k127_7339816_3 Tryptophan halogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003717 271.0
TLS2_k127_7339816_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000001142 248.0
TLS2_k127_7339816_5 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 2.7.7.85 0.0000000000000000000000000000000000000000000000000000000000000007711 233.0
TLS2_k127_7339816_6 RadC-like JAB domain K03630 - - 0.00000000000000000000000000000000000000000000000000000000000002546 228.0
TLS2_k127_7339816_7 Pterin binding enzyme K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000392 225.0
TLS2_k127_7339816_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.000000000000000000000000000000000000000000000000001136 186.0
TLS2_k127_7339816_9 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000001982 193.0
TLS2_k127_7374020_0 FAD dependent oxidoreductase - - - 0.0 1055.0
TLS2_k127_7374020_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - - 3.231e-320 998.0
TLS2_k127_7374020_10 Hsp20/alpha crystallin family K13993 - - 0.000000000000000000000000005303 124.0
TLS2_k127_7374020_11 - - - - 0.000001583 59.0
TLS2_k127_7374020_2 Bacterial extracellular solute-binding protein K02055 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 362.0
TLS2_k127_7374020_3 nitric oxide reductase activity K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 357.0
TLS2_k127_7374020_4 Belongs to the peptidase S33 family K01259,K18457 - 3.4.11.5,3.5.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 322.0
TLS2_k127_7374020_5 zinc ion binding K07048 GO:0008150,GO:0009888,GO:0009987,GO:0030154,GO:0030855,GO:0032502,GO:0048856,GO:0048869,GO:0060429 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 320.0
TLS2_k127_7374020_6 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 307.0
TLS2_k127_7374020_7 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002656 288.0
TLS2_k127_7374020_8 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000124 251.0
TLS2_k127_7374020_9 GYD domain - - - 0.0000000000000000000000000008767 115.0
TLS2_k127_7407199_0 Periplasmic binding protein domain K01999 - - 9.519e-195 614.0
TLS2_k127_7407199_1 ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 374.0
TLS2_k127_7407199_2 cytochrome p450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 388.0
TLS2_k127_7407199_3 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005856 360.0
TLS2_k127_7407199_4 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001394 259.0
TLS2_k127_7407199_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00034,K03366 - 1.1.1.304,1.1.1.47,1.1.1.76 0.0000000000000000000000000000000000000000000000001513 189.0
TLS2_k127_7407199_6 Enoyl-CoA hydratase K16425 GO:0003674,GO:0003824,GO:0004300,GO:0016829,GO:0016835,GO:0016836 - 0.0000000000000000000000000000000000000000000001424 178.0
TLS2_k127_7407199_7 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000005342 109.0
TLS2_k127_7407199_8 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000005915 77.0
TLS2_k127_7407199_9 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0003675 53.0
TLS2_k127_7422116_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 4.291e-195 636.0
TLS2_k127_7422116_1 PFAM iron-containing alcohol dehydrogenase K00001,K11173,K13954 - 1.1.1.1,1.1.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 560.0
TLS2_k127_7422116_10 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000001612 199.0
TLS2_k127_7422116_11 hydrolase (HAD superfamily) K07025 - - 0.000000000000000000000000000003871 136.0
TLS2_k127_7422116_12 methyltransferase activity - - - 0.00000000000000000000000000002749 127.0
TLS2_k127_7422116_13 Alpha beta hydrolase - - - 0.0000000000000000000000000002261 125.0
TLS2_k127_7422116_14 Rhodanese Homology Domain - - - 0.00000000000000000000001243 107.0
TLS2_k127_7422116_15 - - - - 0.0000000000002957 74.0
TLS2_k127_7422116_16 lytic transglycosylase activity - - - 0.00000001549 64.0
TLS2_k127_7422116_17 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000016 57.0
TLS2_k127_7422116_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 559.0
TLS2_k127_7422116_3 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 497.0
TLS2_k127_7422116_4 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000979 466.0
TLS2_k127_7422116_5 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 387.0
TLS2_k127_7422116_6 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000003205 268.0
TLS2_k127_7422116_7 COGs COG1801 conserved - - - 0.00000000000000000000000000000000000000000000000000000001361 226.0
TLS2_k127_7422116_8 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000006313 203.0
TLS2_k127_7422116_9 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000006326 202.0
TLS2_k127_7458923_0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase - - - 4.878e-306 961.0
TLS2_k127_7458923_1 PFAM AMP-dependent synthetase and ligase - - - 3.076e-236 740.0
TLS2_k127_7458923_10 protein, possibly involved in utilization of glycolate and propanediol - - - 0.0000000000000000000000000000000000000000000000000000000701 198.0
TLS2_k127_7458923_11 Histidine kinase-like ATPases K17752 - 2.7.11.1 0.00000000000000000000000000000000000000000000000003658 186.0
TLS2_k127_7458923_12 PFAM Sulphate transporter antisigma-factor antagonist STAS K17762 - - 0.0000000000000000000000000000000000000000000001366 186.0
TLS2_k127_7458923_13 Methyltransferase domain - - - 0.000000000000000000000000000000000000007916 166.0
TLS2_k127_7458923_14 Adenylate guanylate cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000006238 147.0
TLS2_k127_7458923_15 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000001745 125.0
TLS2_k127_7458923_16 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000001372 110.0
TLS2_k127_7458923_17 PFAM response regulator receiver - - - 0.0000000000000000009225 92.0
TLS2_k127_7458923_18 PLD-like domain K06131 - - 0.000000000000000001357 87.0
TLS2_k127_7458923_19 Transcriptional regulatory protein, C terminal K02483,K07669 - - 0.000000000000000004569 89.0
TLS2_k127_7458923_2 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 577.0
TLS2_k127_7458923_20 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes K06131 - - 0.00000000000005382 78.0
TLS2_k127_7458923_22 Phospholipase D. Active site motifs. K06131 - - 0.00000001568 66.0
TLS2_k127_7458923_23 Phospholipase D. Active site motifs. K00995,K06131 - 2.7.8.5 0.000003205 56.0
TLS2_k127_7458923_24 - - - - 0.000006504 51.0
TLS2_k127_7458923_25 PLD-like domain K00995,K06131 - 2.7.8.5 0.00007088 48.0
TLS2_k127_7458923_26 Zinc-binding dehydrogenase - - - 0.0001872 49.0
TLS2_k127_7458923_3 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 494.0
TLS2_k127_7458923_4 His Kinase A (phosphoacceptor) domain K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 482.0
TLS2_k127_7458923_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 390.0
TLS2_k127_7458923_6 RsbT co-antagonist protein rsbRD N-terminal domain K17763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 347.0
TLS2_k127_7458923_7 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 349.0
TLS2_k127_7458923_8 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 291.0
TLS2_k127_7458923_9 Stage II sporulation protein E - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002905 287.0
TLS2_k127_747480_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 4.125e-289 917.0
TLS2_k127_747480_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007112 587.0
TLS2_k127_747480_10 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002892 295.0
TLS2_k127_747480_11 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009691 267.0
TLS2_k127_747480_12 Belongs to the arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000001684 231.0
TLS2_k127_747480_13 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000233 215.0
TLS2_k127_747480_14 Histidine kinase K02482,K03557 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000001061 218.0
TLS2_k127_747480_15 Belongs to the UPF0234 family K09767 - - 0.00000000000000000000000000000000000000000000000000002237 192.0
TLS2_k127_747480_16 Belongs to the CinA family K03742,K03743 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 3.5.1.42 0.00000000000000000000000000000000000000000000000001335 207.0
TLS2_k127_747480_17 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000000000000000000000003636 148.0
TLS2_k127_747480_18 ECF sigma factor K03088 - - 0.00000000000000000000000000000000003705 141.0
TLS2_k127_747480_19 Multi-sensor signal transduction multi-kinase - - - 0.0000000000000000000000000000000004049 148.0
TLS2_k127_747480_2 Ftsk_gamma K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008267 549.0
TLS2_k127_747480_20 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07710 - 2.7.13.3 0.0000000000000000000000000000000007912 147.0
TLS2_k127_747480_21 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.0000000000000000000000000000003707 132.0
TLS2_k127_747480_22 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 0.000000000000000000000000000001264 138.0
TLS2_k127_747480_23 Methyltransferase domain - - - 0.00000000000000000000000000004343 131.0
TLS2_k127_747480_24 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.0000000000000000000000008212 109.0
TLS2_k127_747480_25 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.000000000000001446 78.0
TLS2_k127_747480_26 Tetratricopeptide repeat - - - 0.000000000000006403 86.0
TLS2_k127_747480_27 regulation of DNA repair K03565 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000001262 74.0
TLS2_k127_747480_28 Putative member of DMT superfamily (DUF486) K09922 - - 0.000009229 49.0
TLS2_k127_747480_29 Anti-sigma-K factor rskA - - - 0.000058 55.0
TLS2_k127_747480_3 PFAM acyl-CoA dehydrogenase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007997 518.0
TLS2_k127_747480_4 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 481.0
TLS2_k127_747480_5 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 446.0
TLS2_k127_747480_6 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 381.0
TLS2_k127_747480_7 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009578 339.0
TLS2_k127_747480_8 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 304.0
TLS2_k127_747480_9 SMART PUA domain containing protein K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002912 302.0
TLS2_k127_786844_0 Methionine synthase K00548 - 2.1.1.13 0.0 1060.0
TLS2_k127_786844_1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - 5.854e-260 810.0
TLS2_k127_786844_10 Evidence 4 Homologs of previously reported genes of - - - 0.0000001069 63.0
TLS2_k127_786844_2 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 466.0
TLS2_k127_786844_3 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004561 385.0
TLS2_k127_786844_4 3'-5' exonuclease K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000003765 273.0
TLS2_k127_786844_5 Belongs to the short-chain dehydrogenases reductases (SDR) family - GO:0003674,GO:0003824,GO:0004303,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006066,GO:0006629,GO:0007568,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0014070,GO:0016125,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0018812,GO:0030283,GO:0032502,GO:0033764,GO:0033993,GO:0042221,GO:0042493,GO:0042579,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044594,GO:0046983,GO:0048545,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071407,GO:0071704,GO:1901360,GO:1901615,GO:1902652 - 0.0000000000000000000000000000000000000000000000000000000000008661 219.0
TLS2_k127_786844_6 mannose-1-phosphate guanylyltransferase activity K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000008359 209.0
TLS2_k127_786844_7 CoA-binding protein K06929 - - 0.0000000000000000000000000000000000000972 150.0
TLS2_k127_786844_8 gag-polyprotein putative aspartyl protease - - - 0.000000000000000001813 99.0
TLS2_k127_786844_9 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000001503 75.0
TLS2_k127_806607_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 6.324e-301 956.0
TLS2_k127_806607_1 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.0000000001802 63.0
TLS2_k127_806607_2 Transmembrane secretion effector - - - 0.0006629 48.0
TLS2_k127_868681_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 525.0
TLS2_k127_868681_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 436.0
TLS2_k127_868681_10 protein, possibly involved in aromatic compounds catabolism K02614 - - 0.00000000000000000003471 107.0
TLS2_k127_868681_11 - - - - 0.0000000000000172 83.0
TLS2_k127_868681_12 NmrA-like family - - - 0.0000000003702 67.0
TLS2_k127_868681_13 Enoyl-(Acyl carrier protein) reductase - - - 0.00003554 49.0
TLS2_k127_868681_14 - - - - 0.0005313 51.0
TLS2_k127_868681_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 415.0
TLS2_k127_868681_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 385.0
TLS2_k127_868681_4 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003995 271.0
TLS2_k127_868681_5 Fatty acid desaturase K00508 - 1.14.19.3 0.0000000000000000000000000000000000000000000000000000000000000002062 226.0
TLS2_k127_868681_6 - - - - 0.00000000000000000000000000000000000000000004229 176.0
TLS2_k127_868681_7 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000448 164.0
TLS2_k127_868681_8 Major Facilitator Superfamily - - - 0.00000000000000000000000000007505 119.0
TLS2_k127_868681_9 Arabinose efflux permease family protein - - - 0.000000000000000000000000002101 126.0
TLS2_k127_872028_0 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009809 482.0
TLS2_k127_872028_1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 385.0
TLS2_k127_872028_10 Putative beta-barrel porin 2 - - - 0.00000274 55.0
TLS2_k127_872028_2 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 370.0
TLS2_k127_872028_3 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 351.0
TLS2_k127_872028_4 Poly A polymerase head domain K00970,K00974,K07276,K19545 - 2.7.7.19,2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 304.0
TLS2_k127_872028_5 Pfam:KaiC - - - 0.0000000000000000000000000000000000000000000000000000000003521 229.0
TLS2_k127_872028_6 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.00000000000000000000000000000000000000000000000000000001793 208.0
TLS2_k127_872028_7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.000000000000000000000000000000000000000002487 163.0
TLS2_k127_872028_8 response regulator receiver K13599 - - 0.0000000000000000001281 93.0
TLS2_k127_872028_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000006132 69.0
TLS2_k127_936808_0 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 591.0
TLS2_k127_936808_1 Extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007221 260.0
TLS2_k127_936808_2 Class II Aldolase and Adducin N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000005014 221.0
TLS2_k127_936808_3 PFAM Formylglycine-generating sulfatase enzyme K18912,K20333 - 1.14.99.50 0.0000000000000000000000000000000000000000000001986 187.0
TLS2_k127_936808_4 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000002615 135.0
TLS2_k127_939840_0 Hydantoinaseoxoprolinase domain protein K01469,K01473 - 3.5.2.14,3.5.2.9 2.484e-238 756.0
TLS2_k127_939840_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 2.994e-221 696.0
TLS2_k127_939840_10 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005572 365.0
TLS2_k127_939840_11 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 355.0
TLS2_k127_939840_12 oxidation-reduction process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007524 266.0
TLS2_k127_939840_13 helix_turn _helix lactose operon repressor K02525,K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002586 263.0
TLS2_k127_939840_14 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 GO:0006810,GO:0008150,GO:0015716,GO:0051179,GO:0051234,GO:0071702 3.6.3.28 0.000000000000000000000000000000000000000000000000000000000000000000005077 242.0
TLS2_k127_939840_15 Mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000001507 230.0
TLS2_k127_939840_16 AAA domain, putative AbiEii toxin, Type IV TA system K09695 - - 0.00000000000000000000000000000000000000000000000000000000000002344 226.0
TLS2_k127_939840_17 with the TIM-barrel fold - - - 0.000000000000000000000000000000000000000000000000000000000001412 220.0
TLS2_k127_939840_18 COG3639 ABC-type phosphate phosphonate transport system permease component K02042 - - 0.0000000000000000000000000000000000000000000000000000001033 212.0
TLS2_k127_939840_19 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000002827 201.0
TLS2_k127_939840_2 Hydantoinase/oxoprolinase K01469,K01473 - 3.5.2.14,3.5.2.9 2.841e-207 666.0
TLS2_k127_939840_20 Phosphonate ABC transporter K02044 - - 0.0000000000000000000000000000000000000000000001592 188.0
TLS2_k127_939840_21 ABC-2 family transporter protein K09694 - - 0.000000000000000000000000000000000000000000005614 173.0
TLS2_k127_939840_22 PFAM oxidoreductase domain protein - - - 0.00000000000000000000000000000000000312 158.0
TLS2_k127_939840_23 Belongs to the enoyl-CoA hydratase isomerase family K15019 - 4.2.1.116 0.000000000000000000000000000000000429 143.0
TLS2_k127_939840_24 Cytidylate kinase-like family - - - 0.0000000000000000000000004508 116.0
TLS2_k127_939840_25 PFAM Glyoxalase bleomycin resistance protein dioxygenase K08234 - - 0.0000000000000000000006962 111.0
TLS2_k127_939840_26 metal-dependent hydrolase with the TIM-barrel fold - - - 0.0000000000000001319 82.0
TLS2_k127_939840_27 - - - - 0.000000003625 71.0
TLS2_k127_939840_28 PFAM Uncharacterised protein domain Spy-rel - - - 0.00000003376 61.0
TLS2_k127_939840_3 Prolyl oligopeptidase family - - - 2.652e-195 617.0
TLS2_k127_939840_4 Hydantoinase B/oxoprolinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009228 594.0
TLS2_k127_939840_5 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 536.0
TLS2_k127_939840_6 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 533.0
TLS2_k127_939840_7 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 499.0
TLS2_k127_939840_8 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 477.0
TLS2_k127_939840_9 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 392.0
TLS2_k127_941755_0 Glucoamylase and related glycosyl hydrolases - - - 1.246e-263 833.0
TLS2_k127_941755_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 507.0
TLS2_k127_941755_2 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 381.0
TLS2_k127_941755_3 KR domain K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 307.0
TLS2_k127_941755_4 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.000000000000413 78.0
TLS2_k127_941755_5 endoribonuclease L-PSP K09022 GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019239,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046360,GO:0046361,GO:0046394,GO:0046459,GO:0051790,GO:0071704,GO:0072330,GO:1901576 3.5.99.10 0.000000713 53.0
TLS2_k127_990033_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003489 613.0
TLS2_k127_990033_1 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006457 606.0
TLS2_k127_990033_10 Dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008199 290.0
TLS2_k127_990033_11 PFAM UbiA prenyltransferase K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000664 291.0
TLS2_k127_990033_12 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009899 275.0
TLS2_k127_990033_13 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000005565 262.0
TLS2_k127_990033_14 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000001614 250.0
TLS2_k127_990033_15 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004673 263.0
TLS2_k127_990033_16 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000001915 186.0
TLS2_k127_990033_17 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.00000000000000000000000000000000000000000001499 168.0
TLS2_k127_990033_18 Predicted permease - - - 0.00000000000000000000000000000005596 131.0
TLS2_k127_990033_19 Histidine kinase K13924 - 2.1.1.80,3.1.1.61 0.00000000000137 82.0
TLS2_k127_990033_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007365 605.0
TLS2_k127_990033_3 ATP:ADP antiporter activity K03301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000822 521.0
TLS2_k127_990033_4 Mismatch repair ATPase (MutS family) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008016 530.0
TLS2_k127_990033_5 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 449.0
TLS2_k127_990033_6 Taurine catabolism dioxygenase TauD, TfdA family K03119,K22303 - 1.14.11.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004378 398.0
TLS2_k127_990033_7 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 325.0
TLS2_k127_990033_8 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 336.0
TLS2_k127_990033_9 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 325.0
TLS2_k127_999162_0 type VI secretion ATPase, ClpV1 family K11907 - - 0.0 1219.0
TLS2_k127_999162_1 type VI secretion protein K11891 - - 0.0 1052.0
TLS2_k127_999162_10 type VI secretion protein K11893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 535.0
TLS2_k127_999162_11 von Willebrand factor, type A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007885 574.0
TLS2_k127_999162_12 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 503.0
TLS2_k127_999162_13 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003433 525.0
TLS2_k127_999162_14 Belongs to the Glu Leu Phe Val dehydrogenases family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008182 519.0
TLS2_k127_999162_15 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 463.0
TLS2_k127_999162_16 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 473.0
TLS2_k127_999162_17 Belongs to the amidase family K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006517 464.0
TLS2_k127_999162_18 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 454.0
TLS2_k127_999162_19 TIGRFAM type IV VI secretion system protein, DotU family K11892 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 436.0
TLS2_k127_999162_2 Adenylate and Guanylate cyclase catalytic domain - - - 4.178e-278 898.0
TLS2_k127_999162_20 Peptidase dimerisation domain K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 400.0
TLS2_k127_999162_21 ATPase associated with K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 396.0
TLS2_k127_999162_22 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 386.0
TLS2_k127_999162_23 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008178 387.0
TLS2_k127_999162_24 Caspase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 388.0
TLS2_k127_999162_25 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 376.0
TLS2_k127_999162_26 Pfam:T6SS_VasB K11895 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 377.0
TLS2_k127_999162_27 Pyridoxal phosphate biosynthetic protein PdxA K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 368.0
TLS2_k127_999162_28 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K14161 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 357.0
TLS2_k127_999162_29 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 348.0
TLS2_k127_999162_3 type VI secretion protein K11900 - - 8.035e-263 815.0
TLS2_k127_999162_30 PFAM Extracellular ligand-binding receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 343.0
TLS2_k127_999162_31 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 327.0
TLS2_k127_999162_32 TIGRFAM type VI secretion system FHA domain protein K07169,K11913 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009432 321.0
TLS2_k127_999162_33 Alpha/beta hydrolase family K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009991 319.0
TLS2_k127_999162_34 ImpE protein K11898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003298 308.0
TLS2_k127_999162_35 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 294.0
TLS2_k127_999162_36 serine O-acetyltransferase K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004852 278.0
TLS2_k127_999162_37 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004138 273.0
TLS2_k127_999162_38 Type VI secretion system, VipA, VC_A0107 or Hcp2 K11901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004775 269.0
TLS2_k127_999162_39 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004199 278.0
TLS2_k127_999162_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.16e-262 840.0
TLS2_k127_999162_40 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001703 263.0
TLS2_k127_999162_41 acyl-CoA dehydrogenase activity K00248,K00253 - 1.3.8.1,1.3.8.4 0.000000000000000000000000000000000000000000000000000000000000000000000000002272 283.0
TLS2_k127_999162_42 pathogenesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004472 269.0
TLS2_k127_999162_43 transferase activity, transferring glycosyl groups K00754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009228 261.0
TLS2_k127_999162_44 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001144 268.0
TLS2_k127_999162_45 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000001745 257.0
TLS2_k127_999162_46 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000001029 252.0
TLS2_k127_999162_47 PFAM ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000009135 241.0
TLS2_k127_999162_48 TIGRFAM type VI secretion-associated protein, ImpA family K11902 - - 0.000000000000000000000000000000000000000000000000000000000000000000289 242.0
TLS2_k127_999162_49 branched-chain amino acid transport system, permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000003656 255.0
TLS2_k127_999162_5 Type VI secretion protein K11896 - - 2.035e-216 696.0
TLS2_k127_999162_50 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000008653 239.0
TLS2_k127_999162_51 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K07052 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000001301 246.0
TLS2_k127_999162_52 TIGRFAM Type VI secretion system effector, Hcp1 K11903 - - 0.000000000000000000000000000000000000000000000000000000000000000009617 228.0
TLS2_k127_999162_53 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.00000000000000000000000000000000000000000000000000000000000001645 220.0
TLS2_k127_999162_54 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000001762 225.0
TLS2_k127_999162_55 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000005596 234.0
TLS2_k127_999162_56 Protein of unknown function (DUF455) K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000002 203.0
TLS2_k127_999162_57 Protein serine threonine phosphatase K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000003144 194.0
TLS2_k127_999162_58 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.000000000000000000000000000000000000000000000001769 184.0
TLS2_k127_999162_59 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000005556 188.0
TLS2_k127_999162_6 heat shock protein 70 K04043,K04044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003709 615.0
TLS2_k127_999162_61 type VI secretion system K11897 - - 0.000000000000000000000000000000000000000000009548 169.0
TLS2_k127_999162_62 GDP-mannose mannosyl hydrolase activity K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000002443 167.0
TLS2_k127_999162_63 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000009653 183.0
TLS2_k127_999162_64 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000001321 178.0
TLS2_k127_999162_65 Putative nucleotide-binding of sugar-metabolising enzyme K22129 - 2.7.1.219,2.7.1.220 0.00000000000000000000000000000000000000001734 167.0
TLS2_k127_999162_66 oxidoreductase activity - - - 0.00000000000000000000000000000000000000009 176.0
TLS2_k127_999162_67 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000001474 164.0
TLS2_k127_999162_68 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000005619 161.0
TLS2_k127_999162_69 Uncharacterized protein conserved in bacteria (DUF2094) K11890 - - 0.000000000000000000000000000000000003947 158.0
TLS2_k127_999162_7 Carboxyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009321 611.0
TLS2_k127_999162_70 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000002543 146.0
TLS2_k127_999162_71 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.0000000000000000000000000000000001362 144.0
TLS2_k127_999162_72 Transcriptional regulator - - - 0.0000000000000000000000000000000376 131.0
TLS2_k127_999162_73 Thioesterase superfamily K18700 - 3.1.2.29 0.0000000000000000000000000000001615 129.0
TLS2_k127_999162_74 DinB superfamily K07552 - - 0.0000000000000000000000000000002084 131.0
TLS2_k127_999162_75 Thioredoxin-like - - - 0.0000000000000000000000000000007554 130.0
TLS2_k127_999162_76 PAAR motif - - - 0.000000000000000000000000000001144 124.0
TLS2_k127_999162_77 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000002064 123.0
TLS2_k127_999162_78 TIGRFAM type VI secretion lipoprotein, VC_A0113 family K11906 - - 0.000000000000000000000000003342 117.0
TLS2_k127_999162_79 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE - - - 0.00000000000000000000000003856 114.0
TLS2_k127_999162_8 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 555.0
TLS2_k127_999162_80 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000005617 120.0
TLS2_k127_999162_81 Iron-sulphur cluster assembly - - - 0.000000000000000000000003094 109.0
TLS2_k127_999162_82 DnaJ molecular chaperone homology domain K04082 - - 0.0000000000000000000003567 105.0
TLS2_k127_999162_83 Peptidoglycan-binding domain 1 protein K07126,K13582 - - 0.00000000000000000001795 100.0
TLS2_k127_999162_84 TIGRFAM FeS cluster assembly scaffold protein NifU K04488 - - 0.00000000000000000002659 105.0
TLS2_k127_999162_85 - - - - 0.0000000000000000002429 104.0
TLS2_k127_999162_86 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000006278 95.0
TLS2_k127_999162_87 Protein of unknown function (DUF455) - - - 0.000000000000000152 92.0
TLS2_k127_999162_88 Biotin-requiring enzyme - - - 0.0000000000000001782 81.0
TLS2_k127_999162_89 Pup-like protein K13570 - - 0.0000000000000003219 81.0
TLS2_k127_999162_9 rhs element vgr protein K11904 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 571.0
TLS2_k127_999162_90 - - - - 0.00000000000006836 74.0
TLS2_k127_999162_92 TIGRFAM regulatory protein, FmdB - - - 0.00000000006405 64.0
TLS2_k127_999162_94 - - - - 0.000000003911 69.0
TLS2_k127_999162_95 - - - - 0.000009426 59.0
TLS2_k127_999162_96 Helix-turn-helix domain - - - 0.00003576 52.0