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Overview

ID MAG04014
Name TLS2_bin.54
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Thermoanaerobaculia
Order Multivoradales
Family DATKCC01
Genus DATKCC01
Species
Assembly information
Completeness (%) 81.87
Contamination (%) 0.87
GC content (%) 74.0
N50 (bp) 7,108
Genome size (bp) 3,694,660

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3006

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1003695_0 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 359.0
TLS2_k127_1003695_1 Cytochrome c7 and related cytochrome c K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005639 283.0
TLS2_k127_100485_0 Prolyl oligopeptidase K01322 - 3.4.21.26 2.91e-293 923.0
TLS2_k127_100485_1 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 557.0
TLS2_k127_100485_10 - - - - 0.000001176 56.0
TLS2_k127_100485_2 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 513.0
TLS2_k127_100485_3 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 403.0
TLS2_k127_100485_4 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 379.0
TLS2_k127_100485_5 Integral membrane protein TerC family K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 364.0
TLS2_k127_100485_6 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000006227 165.0
TLS2_k127_100485_7 PFAM phospholipase Carboxylesterase - - - 0.000000000000000000000000000000000007483 144.0
TLS2_k127_100485_8 PAS domain - - - 0.000000000000000000000000000005222 132.0
TLS2_k127_100485_9 - - - - 0.00000000000000008433 94.0
TLS2_k127_1014890_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 354.0
TLS2_k127_1014890_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000003348 245.0
TLS2_k127_1014890_2 PFAM histone deacetylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000005206 207.0
TLS2_k127_1014890_3 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000002648 181.0
TLS2_k127_1014890_4 COG3119 Arylsulfatase A and related enzymes - - - 0.0000000000000000000000000000000000000000002967 183.0
TLS2_k127_1014890_5 PKD domain K01176,K01179,K02395,K21429 - 3.2.1.1,3.2.1.4 0.00000000000000000000000000000000006032 149.0
TLS2_k127_1014890_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03116,K03117 - - 0.0000000000000397 81.0
TLS2_k127_1014890_7 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.000000006939 58.0
TLS2_k127_1016698_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 9.273e-301 943.0
TLS2_k127_1016698_1 COGs COG1680 Beta-lactamase class C and other penicillin binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002826 302.0
TLS2_k127_1016698_2 Saccharopine dehydrogenase NADP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008986 258.0
TLS2_k127_1016698_3 Metal-sensitive transcriptional repressor K21600 - - 0.00000000000000000000001114 104.0
TLS2_k127_1018203_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000006516 210.0
TLS2_k127_1018203_1 Helix-turn-helix K21498 - - 0.0000000000000000003659 90.0
TLS2_k127_1018203_2 DNA polymerase beta domain protein region - - - 0.0000001014 60.0
TLS2_k127_1019336_0 aldehyde oxidase and xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 3.467e-232 738.0
TLS2_k127_1019336_1 2Fe-2S -binding K13483 - - 0.0000000000000000000000000000000000000008748 150.0
TLS2_k127_1019336_2 PFAM molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.000169 54.0
TLS2_k127_1019344_0 aldehyde oxidase and xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 604.0
TLS2_k127_1019344_1 PFAM molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.0002085 54.0
TLS2_k127_1020665_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 566.0
TLS2_k127_1020665_1 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000001908 207.0
TLS2_k127_1020665_2 Fibronectin type III domain protein - - - 0.00000000005475 74.0
TLS2_k127_1036051_0 Peptidase, M16 K07263 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 5.036e-239 775.0
TLS2_k127_1036051_1 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 445.0
TLS2_k127_1036051_2 Putative transposase of IS4/5 family (DUF4096) K07492 - - 0.000000007071 57.0
TLS2_k127_1036957_0 Carboxyl transferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005612 577.0
TLS2_k127_1036957_1 Mo-molybdopterin cofactor metabolic process K03636,K21142 - 2.8.1.12 0.00001205 55.0
TLS2_k127_1044608_0 Carbon starvation protein K06200 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 521.0
TLS2_k127_1044608_1 tRNA methyl transferase K21027 - 2.8.1.14 0.00000000000000000000000000000000000000000000000000000000009749 209.0
TLS2_k127_1055698_0 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 404.0
TLS2_k127_1055698_1 PFAM transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.00000000000000006739 81.0
TLS2_k127_1055698_2 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000004423 69.0
TLS2_k127_1056847_0 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008405 512.0
TLS2_k127_1056847_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 435.0
TLS2_k127_1056847_2 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000002836 118.0
TLS2_k127_1061200_0 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 340.0
TLS2_k127_1061200_1 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000004219 105.0
TLS2_k127_1061200_2 cellular modified histidine biosynthetic process K18802 - - 0.00001526 54.0
TLS2_k127_1062544_0 Domain of unknown function (DUF3471) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003191 467.0
TLS2_k127_1062544_1 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003268 459.0
TLS2_k127_1062544_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170,K00187 - 1.2.7.1,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009917 385.0
TLS2_k127_1062544_3 protein conserved in cyanobacteria - - - 0.000000000000000000000000000000000000000003728 158.0
TLS2_k127_1062544_4 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.0000000000000000000000000002551 121.0
TLS2_k127_1066996_0 Sortilin, neurotensin receptor 3, - - - 0.0 1104.0
TLS2_k127_1066996_1 cellulose binding - - - 0.0 1040.0
TLS2_k127_1066996_10 PFAM Uncharacterised protein family UPF0150 K03088,K07110 - - 0.0005907 48.0
TLS2_k127_1066996_2 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 287.0
TLS2_k127_1066996_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003858 273.0
TLS2_k127_1066996_4 Protein of unknown function (DUF1697) - - - 0.000000000000000000000000000000000000000000000000000002878 196.0
TLS2_k127_1066996_5 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000000000000000000000000001089 185.0
TLS2_k127_1066996_6 FG-GAP repeat - - - 0.00000000000000000000000000000000000000000004162 177.0
TLS2_k127_1066996_7 Trypsin K04691,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - 0.000000000000009257 81.0
TLS2_k127_1066996_8 transcriptional regulator - - - 0.00001341 53.0
TLS2_k127_1066996_9 serine-type endopeptidase activity - - - 0.0000984 52.0
TLS2_k127_1067192_0 ATP-binding region, ATPase domain protein domain protein K07678,K10909 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 0.0000000000000000000000000000000000000000000000000000001024 222.0
TLS2_k127_1067192_1 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.00000000000000000000000000000000000000000009304 169.0
TLS2_k127_1067192_2 Response regulator receiver domain - - - 0.00000000000000000002069 100.0
TLS2_k127_1067192_4 Protein of unknown function (DUF2892) - - - 0.00000000000003421 81.0
TLS2_k127_1083000_0 PFAM Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000000000000000001675 150.0
TLS2_k127_1083000_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000000000000000000000000000001837 126.0
TLS2_k127_1083000_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000001178 71.0
TLS2_k127_1090535_0 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000359 286.0
TLS2_k127_1090535_1 - - - - 0.0000001217 57.0
TLS2_k127_1109888_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - 1.492e-254 794.0
TLS2_k127_1113244_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 344.0
TLS2_k127_1122561_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008768 524.0
TLS2_k127_112604_0 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000007703 250.0
TLS2_k127_112604_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000001302 248.0
TLS2_k127_112604_2 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000000000000000008486 213.0
TLS2_k127_112604_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.00000000000000000000000000000000000000000000000000554 210.0
TLS2_k127_112604_4 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000347 75.0
TLS2_k127_112604_5 Belongs to the UPF0434 family K09791 - - 0.0000000002574 64.0
TLS2_k127_1152240_0 Patatin-like phospholipase - - - 7.738e-195 647.0
TLS2_k127_1152240_1 COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000001075 178.0
TLS2_k127_1152240_2 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000000000000002618 151.0
TLS2_k127_1152240_3 serine-type aminopeptidase activity - - - 0.00000000000000000000000000000000004322 149.0
TLS2_k127_1152240_4 chlorophyll binding K03286,K03640 - - 0.000000004925 68.0
TLS2_k127_1152240_5 - - - - 0.0000001865 59.0
TLS2_k127_1172345_0 thioesterase involved in non-ribosomal peptide biosynthesis K01071 - 3.1.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000002722 255.0
TLS2_k127_1172345_1 Belongs to the P-Pant transferase superfamily K06133 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.00000000000000000000000000000000000000000000000006221 188.0
TLS2_k127_1172345_2 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.00000000000000000000000000000000009298 144.0
TLS2_k127_1172345_3 MbtH-like protein K05375,K09190 - - 0.000000000000000000000000000000000786 132.0
TLS2_k127_1172345_4 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.0000000000153 77.0
TLS2_k127_1172345_5 PFAM conserved - - - 0.0000000009862 64.0
TLS2_k127_1172345_6 von Willebrand factor type A domain - - - 0.0005081 44.0
TLS2_k127_1173575_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004114 475.0
TLS2_k127_1173575_1 PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 459.0
TLS2_k127_1173575_2 cog0421, spermidine synthase - - - 0.000000000000000000000000000000000000000000000000000000000006366 215.0
TLS2_k127_1173575_3 Alpha beta hydrolase - - - 0.00000000000000000000000000000000001939 144.0
TLS2_k127_1173575_4 COG1520 FOG WD40-like repeat - - - 0.0000007311 57.0
TLS2_k127_1187026_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000007188 246.0
TLS2_k127_1187026_1 guanosine tetraphosphate metabolic process K07816 - 2.7.6.5 0.00000000000000000000000000000000000000000000000000000000002326 214.0
TLS2_k127_1187026_2 YCII-related domain - - - 0.00000000000000000000000004469 118.0
TLS2_k127_1187026_3 Sigma-70, region 4 K03088 - - 0.00000002699 63.0
TLS2_k127_1205073_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 508.0
TLS2_k127_1205073_1 Belongs to the anaerobic coproporphyrinogen-III oxidase family - GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 477.0
TLS2_k127_1205073_2 protoporphyrinogen oxidase activity K00231,K14266 - 1.14.19.9,1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000001374 191.0
TLS2_k127_1205073_3 FeoA K04758 - - 0.0000000000003745 83.0
TLS2_k127_1208888_0 Tryptophan halogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006012 416.0
TLS2_k127_1210002_0 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007985 523.0
TLS2_k127_1210002_1 PFAM AMP-dependent synthetase and ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 500.0
TLS2_k127_121132_0 Amidohydrolase family - - - 0.0 1365.0
TLS2_k127_121132_1 UMP kinase activity K00947,K09903 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030151,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 401.0
TLS2_k127_121132_2 Amino acid kinase family K00947 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 380.0
TLS2_k127_121132_3 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 336.0
TLS2_k127_121132_4 COG4149 ABC-type molybdate transport system, permease component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000702 318.0
TLS2_k127_121132_5 COG0725 ABC-type molybdate transport system, periplasmic component K02020 GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168 - 0.00000000000000000000000000000000000000000000000000006051 190.0
TLS2_k127_121132_6 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000007788 171.0
TLS2_k127_121132_7 Protein conserved in bacteria K09922 - - 0.000000000000000000000000000000000000000001872 162.0
TLS2_k127_121132_8 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000005009 154.0
TLS2_k127_121132_9 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000001861 119.0
TLS2_k127_1211995_0 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000003543 216.0
TLS2_k127_1211995_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000000003486 142.0
TLS2_k127_1211995_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000001629 78.0
TLS2_k127_1211995_3 PFAM lipolytic protein G-D-S-L family - - - 0.000000009378 68.0
TLS2_k127_1211995_4 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000001239 62.0
TLS2_k127_1211995_5 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000003676 63.0
TLS2_k127_1211995_6 dockerin type - - - 0.0003654 53.0
TLS2_k127_1215353_0 N-acetylmuramoyl-L-alanine amidase - - - 0.00000579 59.0
TLS2_k127_1215353_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00004578 55.0
TLS2_k127_1218424_0 PFAM Na dependent nucleoside transporter K03317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 430.0
TLS2_k127_1218424_1 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.00000000000000000000000000004969 123.0
TLS2_k127_1230016_0 Peptidase, M61 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 557.0
TLS2_k127_1230016_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 357.0
TLS2_k127_1230016_2 Aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005925 285.0
TLS2_k127_1230016_3 thiolester hydrolase activity K06889 - - 0.00000000000000000000000000000000000000000000000000000000000001528 224.0
TLS2_k127_1230016_4 Redoxin - - - 0.0000000000000000000000000000000000000000000000006398 182.0
TLS2_k127_1230016_5 Thiol disulfide interchange protein K04084,K08344 - 1.8.1.8 0.000000000000000000000000000004282 135.0
TLS2_k127_1238101_0 Hydroxymethylglutaryl-coenzyme A reductase K00021 - 1.1.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 574.0
TLS2_k127_1238101_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 424.0
TLS2_k127_1238101_2 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007959 290.0
TLS2_k127_1238101_3 Porphobilinogen deaminase, dipyromethane cofactor binding domain K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000006101 216.0
TLS2_k127_1238101_4 cytochrome complex assembly - - - 0.00000000000000000000000000000000002712 145.0
TLS2_k127_1238101_5 PFAM Uroporphyrinogen III synthase HEM4 K01719 - 4.2.1.75 0.00000000000000000000000000007141 126.0
TLS2_k127_1238101_6 Protein conserved in bacteria - - - 0.00000000000000000004118 98.0
TLS2_k127_1238474_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 2.54e-206 673.0
TLS2_k127_1238474_1 ErfK YbiS YcfS YnhG family protein K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008224 344.0
TLS2_k127_1238474_2 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000005655 69.0
TLS2_k127_1238474_3 Universal stress protein family - - - 0.00005964 49.0
TLS2_k127_1239775_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 2.563e-255 799.0
TLS2_k127_1239775_1 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000001224 238.0
TLS2_k127_1239775_2 Sigma-70 region 2 - - - 0.0000000003083 68.0
TLS2_k127_1239775_3 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.0000001697 60.0
TLS2_k127_1239775_4 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07712 - - 0.000003549 49.0
TLS2_k127_1239775_5 Permease YjgP YjgQ family K07091 - - 0.0002496 43.0
TLS2_k127_1245526_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 384.0
TLS2_k127_1245526_1 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007522 368.0
TLS2_k127_1245526_10 Rdx family K07401 - - 0.0003627 47.0
TLS2_k127_1245526_11 DNA RNA non-specific endonuclease K01173 - - 0.0008835 45.0
TLS2_k127_1245526_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000007593 218.0
TLS2_k127_1245526_3 GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000004079 185.0
TLS2_k127_1245526_4 UPF0316 protein - - - 0.000000000000000000000000000000000000000000008672 169.0
TLS2_k127_1245526_5 CoA-binding protein K06929 - - 0.000000000000000000000000000000000006104 145.0
TLS2_k127_1245526_6 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000001996 106.0
TLS2_k127_1245526_7 Yqey-like protein K09117 - - 0.00000000000000000000133 100.0
TLS2_k127_1245526_8 ASPIC and UnbV - - - 0.0000000255 57.0
TLS2_k127_1245526_9 Peptidase M56 - - - 0.00000003937 65.0
TLS2_k127_1248599_0 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005675 449.0
TLS2_k127_1248599_1 SpoU rRNA Methylase family K00556 - 2.1.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 309.0
TLS2_k127_1248599_2 Belongs to the UPF0145 family - - - 0.0000000000000000000000000000006332 130.0
TLS2_k127_1248599_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000003439 112.0
TLS2_k127_1248599_4 Putative zinc-finger - - - 0.000000000004672 77.0
TLS2_k127_1251421_0 nucleoside hydrolase - - - 0.00001453 57.0
TLS2_k127_1253765_0 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 309.0
TLS2_k127_1253765_1 Domain of unknown function (DUF4143) K07133 - - 0.0000000000000002405 82.0
TLS2_k127_1260651_0 Penicillin amidase K01434,K07116 - 3.5.1.11,3.5.1.97 6.745e-244 773.0
TLS2_k127_1261064_0 Protein of unknown function (DUF2891) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000506 535.0
TLS2_k127_1261064_1 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000006474 180.0
TLS2_k127_1261064_2 Glyoxalase-like domain K06996 - - 0.000000000000000000000000001436 115.0
TLS2_k127_1274343_0 Ion channel - - - 4.569e-224 707.0
TLS2_k127_1274343_1 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006728 360.0
TLS2_k127_1274343_2 tRNA pseudouridine synthase activity K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000005464 241.0
TLS2_k127_1274343_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000004874 104.0
TLS2_k127_1274343_4 Belongs to the UPF0312 family - - - 0.0000000000000003992 79.0
TLS2_k127_1278632_0 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009536 297.0
TLS2_k127_1278632_1 PFAM Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000001192 255.0
TLS2_k127_1278632_2 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000002879 187.0
TLS2_k127_1278632_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000001737 157.0
TLS2_k127_1278632_4 Protein of unknown function, DUF547 - - - 0.0000000000000000000000000000000000792 139.0
TLS2_k127_1278632_5 Guanylyl transferase CofC like K09931 - - 0.00000000000000000000000008494 117.0
TLS2_k127_1278632_6 oxidoreductase activity - - - 0.0000000000000000001669 103.0
TLS2_k127_1278632_7 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000363 81.0
TLS2_k127_1278632_8 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000001649 59.0
TLS2_k127_1278632_9 Domain of unknown function (DUF4177) - - - 0.00009889 48.0
TLS2_k127_1279162_0 COG2801 Transposase and inactivated derivatives K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000001009 231.0
TLS2_k127_1279162_1 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000002557 211.0
TLS2_k127_1286647_0 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 375.0
TLS2_k127_1286647_1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000003612 205.0
TLS2_k127_128685_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000001759 131.0
TLS2_k127_1296409_0 long-chain fatty acid transporting porin activity K06076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001317 291.0
TLS2_k127_1296409_1 Sortilin, neurotensin receptor 3, - - - 0.0000000000000000000000000000000000000000000000000000000000000000004857 239.0
TLS2_k127_1297701_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008457 525.0
TLS2_k127_1311802_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 392.0
TLS2_k127_1311802_1 Phosphoesterase K07095 - - 0.00000000000000000000000000032 115.0
TLS2_k127_131549_0 isochorismatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000871 456.0
TLS2_k127_131549_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 381.0
TLS2_k127_131549_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 314.0
TLS2_k127_131549_3 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.0000000000000000000000009205 108.0
TLS2_k127_1328265_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000006207 237.0
TLS2_k127_1328265_1 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000192 133.0
TLS2_k127_1328265_2 Belongs to the TrpC family K01609 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 0.0000000000000000000000001487 109.0
TLS2_k127_133433_0 dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006114 284.0
TLS2_k127_133433_1 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000009499 192.0
TLS2_k127_133433_2 CoA binding domain K01905,K22224 - 6.2.1.13 0.0000000000000000000000000000000001428 136.0
TLS2_k127_133433_3 Zinc-binding dehydrogenase - - - 0.0000000000000000000174 93.0
TLS2_k127_1343989_0 Cys/Met metabolism PLP-dependent enzyme K01760,K17217 - 4.4.1.1,4.4.1.2,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008471 481.0
TLS2_k127_1343989_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 360.0
TLS2_k127_1343989_2 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000002609 106.0
TLS2_k127_1343989_3 Histidine kinase - - - 0.00000000000000000000002159 116.0
TLS2_k127_134459_0 branched-chain-amino-acid aminotransferase-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005508 379.0
TLS2_k127_134459_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002215 294.0
TLS2_k127_134459_2 Tricorn protease homolog - - - 0.0000000000000000000000177 104.0
TLS2_k127_134459_4 DNA-templated transcription, initiation - - - 0.000000000000003248 81.0
TLS2_k127_1363906_0 HD superfamily K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 561.0
TLS2_k127_1363906_1 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 493.0
TLS2_k127_1363906_2 - - - - 0.000000000000000000000000000000000000000002223 162.0
TLS2_k127_1363906_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000004765 125.0
TLS2_k127_1363906_4 Glycosyltransferase family 87 - - - 0.00000000000000000000000007998 123.0
TLS2_k127_1363906_5 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.000000000000000003941 91.0
TLS2_k127_1363906_6 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000002777 70.0
TLS2_k127_1364224_0 non-ribosomal peptide synthetase - - - 3.719e-277 893.0
TLS2_k127_1364288_0 non-ribosomal peptide synthetase - - - 0.0 1737.0
TLS2_k127_1364497_0 arylsulfatase activity K01133 - 3.1.6.6 0.00000000000000000000000000000004276 142.0
TLS2_k127_1364497_1 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000008978 113.0
TLS2_k127_1372958_0 Chalcone isomerase-like - - - 0.000000000000000000000000000000000000000000007404 173.0
TLS2_k127_1372958_1 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000000000001684 170.0
TLS2_k127_1372958_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000004887 113.0
TLS2_k127_1372958_3 Polymer-forming cytoskeletal - - - 0.0000001414 63.0
TLS2_k127_1375669_0 Stage II sporulation protein E K07315 - 3.1.3.3 0.0000000000000000000000000000000000009432 158.0
TLS2_k127_1375669_1 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000001776 147.0
TLS2_k127_1375669_2 transcriptional regulator K07729 - - 0.000000000000000000000005591 109.0
TLS2_k127_1375669_3 - - - - 0.000000002953 64.0
TLS2_k127_1379495_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 6.906e-194 648.0
TLS2_k127_1379495_1 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 502.0
TLS2_k127_1379495_10 Thioredoxin - - - 0.000000000000000000004689 100.0
TLS2_k127_1379495_11 Polymer-forming cytoskeletal - - - 0.00000004568 64.0
TLS2_k127_1379495_12 Tetratricopeptide TPR_2 repeat protein - - - 0.0000005638 63.0
TLS2_k127_1379495_2 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 418.0
TLS2_k127_1379495_3 CBS domain-containing protein K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 388.0
TLS2_k127_1379495_4 PFAM 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 349.0
TLS2_k127_1379495_5 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000001283 179.0
TLS2_k127_1379495_6 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog K03088 - - 0.000000000000000000000000000004604 134.0
TLS2_k127_1379495_7 Nucleotidyltransferase domain K07075 - - 0.00000000000000000000000001099 112.0
TLS2_k127_1379495_8 Protein of unknown function DUF86 - - - 0.0000000000000000000001182 112.0
TLS2_k127_1379495_9 - - - - 0.000000000000000000000159 115.0
TLS2_k127_1385867_0 Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA K01893 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000003422 227.0
TLS2_k127_1396037_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 493.0
TLS2_k127_1396037_1 metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000004615 175.0
TLS2_k127_1396037_2 amine dehydrogenase activity - - - 0.000000000000000000000000000002944 140.0
TLS2_k127_1396037_3 Membrane - - - 0.0000000008047 68.0
TLS2_k127_1396037_4 two-component system sensor-response regulator hybrid protein - - - 0.0002794 47.0
TLS2_k127_1405318_0 Aconitase C-terminal domain K01681 - 4.2.1.3 6.186e-247 776.0
TLS2_k127_1405318_1 FtsX-like permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009587 569.0
TLS2_k127_1405318_2 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000002702 144.0
TLS2_k127_1409226_0 Subtilase family K01361,K08652,K14647 GO:0005575,GO:0005576 3.4.21.110,3.4.21.96 0.000000000000000000000000000000000000000000000399 193.0
TLS2_k127_1431546_0 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 6.837e-249 793.0
TLS2_k127_1431546_1 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 424.0
TLS2_k127_1438502_0 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008181 332.0
TLS2_k127_1438502_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000008466 131.0
TLS2_k127_1438502_2 ASPIC and UnbV - - - 0.000000000000000000003155 96.0
TLS2_k127_143891_0 non-ribosomal peptide synthetase - - - 2.154e-239 771.0
TLS2_k127_143891_1 Non-ribosomal peptide synthetase modules and related proteins - - - 0.00000277 58.0
TLS2_k127_1444994_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005957 398.0
TLS2_k127_1444994_1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01476,K01480 - 3.5.3.1,3.5.3.11 0.000000000000000000000000000000000000000000000000002513 191.0
TLS2_k127_1444994_2 Radical SAM superfamily K06871 - - 0.00000000000000000000000000000005498 145.0
TLS2_k127_1444994_3 4Fe-4S single cluster domain K06871 - - 0.00000000000000000000000000002206 133.0
TLS2_k127_1444994_4 B12 binding domain - - - 0.00000000000000000000000000003426 136.0
TLS2_k127_1444994_5 histidine kinase A domain protein - - - 0.00000000000000000521 91.0
TLS2_k127_1458402_0 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 548.0
TLS2_k127_1458402_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003788 438.0
TLS2_k127_1458402_2 Peptidase dimerisation domain K13049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 423.0
TLS2_k127_1458402_3 Belongs to the NadC ModD family K00767,K03813 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005217 347.0
TLS2_k127_1468573_0 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 362.0
TLS2_k127_1468573_1 adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000123 181.0
TLS2_k127_1468573_2 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000162 143.0
TLS2_k127_147264_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 417.0
TLS2_k127_147264_1 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 310.0
TLS2_k127_147264_2 phosphoesterase, PA-phosphatase related - - - 0.000000000000000000000000000003601 134.0
TLS2_k127_1477600_0 Condensation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005181 567.0
TLS2_k127_1477600_1 non-ribosomal peptide synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007225 505.0
TLS2_k127_1480004_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004412 256.0
TLS2_k127_1480004_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000002601 194.0
TLS2_k127_1480004_2 Bacterial membrane protein, YfhO - - - 0.000000000000000000000000000000000000000000005211 188.0
TLS2_k127_1480004_3 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.000000000000000000000000001395 112.0
TLS2_k127_1491438_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.86e-216 700.0
TLS2_k127_1491438_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005893 451.0
TLS2_k127_1491438_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004751 262.0
TLS2_k127_1491438_3 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000004122 101.0
TLS2_k127_1491438_4 COG0733 Na -dependent transporters of the SNF family K03308 - - 0.000000000000007397 77.0
TLS2_k127_1491438_5 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0004823 52.0
TLS2_k127_1493387_0 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K07713,K07714,K19641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 478.0
TLS2_k127_1493387_1 PFAM Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 444.0
TLS2_k127_1493387_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 353.0
TLS2_k127_1507180_0 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000003774 89.0
TLS2_k127_1507180_1 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000952 76.0
TLS2_k127_1507180_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000004219 90.0
TLS2_k127_1507305_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001919 243.0
TLS2_k127_1507305_1 glycosyl transferase family 39 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000002169 250.0
TLS2_k127_1507305_2 Alcohol dehydrogenase GroES-like domain K00001,K13953 - 1.1.1.1 0.00000000000000000000000000001298 119.0
TLS2_k127_1507305_3 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity K03429 - 2.4.1.315 0.000000000000000000004157 95.0
TLS2_k127_1507305_4 Lipid A 3-O-deacylase (PagL) - - - 0.000000002082 67.0
TLS2_k127_1541326_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 521.0
TLS2_k127_1541326_1 electron transport chain K00347,K03614 - 1.6.5.8 0.0000000000000000000000000000000000000002043 161.0
TLS2_k127_154334_0 choline dehydrogenase activity K03333 - 1.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 468.0
TLS2_k127_154334_1 Domain of unknown function (DUF4331) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 420.0
TLS2_k127_154334_10 Arylsulfatase K01130 - 3.1.6.1 0.0002921 53.0
TLS2_k127_154334_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 334.0
TLS2_k127_154334_3 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.000000000000000000000000000000000000000000000000000000000000000000007151 252.0
TLS2_k127_154334_4 long-chain fatty acid transporting porin activity K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000001493 248.0
TLS2_k127_154334_5 Sulfatase - - - 0.00000000000000000000000000000000001048 154.0
TLS2_k127_154334_6 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000001584 135.0
TLS2_k127_154334_7 Acetyltransferase (GNAT) family - - - 0.000000000000000006264 91.0
TLS2_k127_154334_8 - - - - 0.0000000000007237 82.0
TLS2_k127_154334_9 Proline dehydrogenase K00318 - - 0.0000002391 60.0
TLS2_k127_1552626_0 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 547.0
TLS2_k127_1552626_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K13015 - 1.1.1.136 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 552.0
TLS2_k127_1552626_10 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001956 247.0
TLS2_k127_1552626_11 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000006806 214.0
TLS2_k127_1552626_12 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000003595 214.0
TLS2_k127_1552626_13 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000006992 206.0
TLS2_k127_1552626_14 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000001748 200.0
TLS2_k127_1552626_15 Crp-like helix-turn-helix domain K10914 - - 0.0000000000000000000000000000000000000000000001122 192.0
TLS2_k127_1552626_16 Chain length determinant protein K16554 - - 0.000000000000000000000000000000000000000002853 180.0
TLS2_k127_1552626_17 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000963 164.0
TLS2_k127_1552626_18 O-Antigen ligase K02847 - - 0.00000000000000000000000000002738 136.0
TLS2_k127_1552626_2 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 510.0
TLS2_k127_1552626_3 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 408.0
TLS2_k127_1552626_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004222 383.0
TLS2_k127_1552626_5 Domain of unknown function (DUF4091) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004047 371.0
TLS2_k127_1552626_6 Heparinase II/III N-terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003033 323.0
TLS2_k127_1552626_7 Required for morphogenesis under gluconeogenic growth conditions - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004966 274.0
TLS2_k127_1552626_8 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009021 289.0
TLS2_k127_1552626_9 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000268 268.0
TLS2_k127_1561517_0 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase - - - 0.000000000000000000000000000003726 129.0
TLS2_k127_1590726_0 PFAM Peptidase M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003482 282.0
TLS2_k127_1590726_1 - - - - 0.00000000000000007069 87.0
TLS2_k127_160531_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.0 1295.0
TLS2_k127_160531_1 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008317 440.0
TLS2_k127_1635822_0 magnesium chelatase K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004652 534.0
TLS2_k127_1635822_1 ferredoxin-NADP+ reductase activity K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000742 408.0
TLS2_k127_1635822_2 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005745 370.0
TLS2_k127_1635822_3 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 293.0
TLS2_k127_1635822_4 Peptidase family M48 - - - 0.00000000000000000000000000000000000001151 151.0
TLS2_k127_1635822_5 PIN domain K18828 - - 0.000000000000000000000000000000001079 137.0
TLS2_k127_1650546_0 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 542.0
TLS2_k127_1650546_1 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000009263 188.0
TLS2_k127_1650546_2 - - - - 0.0000000000000000000000000000000000000000000008596 172.0
TLS2_k127_1650546_3 - - - - 0.0000000000000000000866 97.0
TLS2_k127_1650546_4 Amidohydrolase family - - - 0.0000000000007676 70.0
TLS2_k127_166300_0 Chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 486.0
TLS2_k127_166300_1 Ribosomal protein S1-like RNA-binding domain K02945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 323.0
TLS2_k127_166300_2 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.000000000000000000001637 94.0
TLS2_k127_166300_3 PFAM cytochrome c class III - - - 0.000000000000007998 80.0
TLS2_k127_1686743_0 Histidine kinase HAMP K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 328.0
TLS2_k127_1686743_1 Belongs to the NiFe NiFeSe hydrogenase large subunit family K14126,K17993 GO:0003674,GO:0005488,GO:0005575,GO:0016151,GO:0032991,GO:0043167,GO:0043169,GO:0044569,GO:0046872,GO:0046914,GO:1902494 1.12.1.3,1.12.1.5,1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001561 289.0
TLS2_k127_172487_0 Non-ribosomal peptide synthetase modules and related proteins K15654 - - 1.429e-306 994.0
TLS2_k127_172487_1 polyketide synthase K04786 - - 2.251e-271 874.0
TLS2_k127_1780298_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005057 564.0
TLS2_k127_1780298_1 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 417.0
TLS2_k127_1780298_2 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000625 376.0
TLS2_k127_1780298_3 non-ribosomal peptide synthetase - - - 0.0000001829 55.0
TLS2_k127_1783849_0 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009529 307.0
TLS2_k127_1783849_1 - - - - 0.000000000000000000000000000000000000000000000000000003026 200.0
TLS2_k127_1783849_2 Male sterility protein K00091,K19997 - 1.1.1.219,5.1.3.26 0.0000000000000000000000000000000000001674 155.0
TLS2_k127_1783849_3 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000003816 151.0
TLS2_k127_1783849_4 arylsulfatase activity - - - 0.0000000000000000000000000000000002521 151.0
TLS2_k127_1783849_5 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000001083 66.0
TLS2_k127_1783849_6 Tetratricopeptide repeat - - - 0.0001032 55.0
TLS2_k127_1798574_0 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004246 269.0
TLS2_k127_1798574_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02484,K07636 - 2.7.13.3 0.0000000000000000000000000000000000008498 147.0
TLS2_k127_1798574_2 - - - - 0.00000000000000000000000000001489 125.0
TLS2_k127_1798574_3 Domain of unknown function (DU1801) - - - 0.00000000000000000000302 95.0
TLS2_k127_1805516_0 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0 1103.0
TLS2_k127_1805516_1 PFAM peptidase M3A and M3B, thimet oligopeptidase F K08602 - - 4.011e-231 730.0
TLS2_k127_1805516_2 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000002723 236.0
TLS2_k127_1805516_3 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K14161 - - 0.0000000000000000000000000000000000000000000000000000479 212.0
TLS2_k127_1805516_4 - - - - 0.0000000000000000000000000000000000000002127 166.0
TLS2_k127_1805516_5 oxidoreductase activity - - - 0.00000000000000000005187 106.0
TLS2_k127_1805516_6 recA bacterial DNA recombination protein - - - 0.000000000434 71.0
TLS2_k127_1815048_0 WD-40 repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007253 335.0
TLS2_k127_1839395_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002627 475.0
TLS2_k127_1839395_1 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000135 179.0
TLS2_k127_1839395_2 FecR protein - - - 0.000000000000000000000000000000000000001391 171.0
TLS2_k127_1839395_3 Cyclic nucleotide-monophosphate binding domain K04739 - - 0.000009415 59.0
TLS2_k127_1842664_0 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase K01082 - 3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000008287 232.0
TLS2_k127_1842664_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000004398 111.0
TLS2_k127_185239_0 Asparaginyl-tRNA synthetase K01893 GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 410.0
TLS2_k127_185239_1 beta' subunit K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000002116 266.0
TLS2_k127_1870771_0 TrkA-C domain - - - 0.0 1021.0
TLS2_k127_1870771_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009962 437.0
TLS2_k127_1870771_2 Sigma-70, region 4 type 2 - - - 0.00000000000000000000000000000000000000000000000000001215 196.0
TLS2_k127_1870771_3 histidine kinase dimerisation and phosphoacceptor region - - - 0.0000000000000000000000000000000000000000000001529 188.0
TLS2_k127_1870771_4 13-prostaglandin reductase activity K00344,K07119 - 1.6.5.5 0.00000000000000000000000000000000000000000003746 164.0
TLS2_k127_1870771_5 Protein of unknown function (DUF3494) - - - 0.000000000006066 76.0
TLS2_k127_1875111_0 Peptidase family S58 K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006595 443.0
TLS2_k127_1876288_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001095 256.0
TLS2_k127_1876288_1 Belongs to the UPF0502 family K09915 - - 0.00000000000000000000000000000000000005155 153.0
TLS2_k127_1884794_0 esterase - - - 7.093e-258 808.0
TLS2_k127_1884794_1 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007796 295.0
TLS2_k127_1884794_2 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.00000000000000000000000000000000000000000000000000000000004959 218.0
TLS2_k127_1884794_3 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000001275 144.0
TLS2_k127_1884794_4 PFAM Glucose Sorbosone dehydrogenase - - - 0.000000000000000000002793 99.0
TLS2_k127_1884794_5 ig-like, plexins, transcription factors - - - 0.000004969 60.0
TLS2_k127_188701_0 efflux transmembrane transporter activity - - - 1.617e-264 841.0
TLS2_k127_188701_1 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006982 416.0
TLS2_k127_188701_2 PFAM Integral membrane protein TerC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009589 422.0
TLS2_k127_188701_3 SIS domain K07106 - 4.2.1.126 0.00000000000000000000000000000000000000000000000000000000000000000316 240.0
TLS2_k127_188701_4 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000001602 189.0
TLS2_k127_188701_5 Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides K02759,K03478 - 2.7.1.196,2.7.1.205,3.5.1.105 0.000000000000000000000000000000000000000000001333 186.0
TLS2_k127_188701_6 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000001125 177.0
TLS2_k127_188701_7 - - - - 0.000000000000000000000000000000000000000009788 160.0
TLS2_k127_188701_8 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 0.00000000000000000000000000000000000004255 162.0
TLS2_k127_188701_9 Transcriptional - - - 0.000000000000000000000000000000001189 136.0
TLS2_k127_1936422_0 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 413.0
TLS2_k127_1936422_1 CBS domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004345 301.0
TLS2_k127_1936422_2 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000001653 159.0
TLS2_k127_1937640_0 Belongs to the ClpA ClpB family K03696 - - 6.614e-286 899.0
TLS2_k127_1937640_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 533.0
TLS2_k127_1937640_10 FabA-like domain K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000001757 183.0
TLS2_k127_1937640_11 PFAM PilT protein domain protein - - - 0.00000000000000000000000000000000001744 140.0
TLS2_k127_1937640_12 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000000003564 94.0
TLS2_k127_1937640_13 Leucine rich repeats (6 copies) - - - 0.00000000000000000007389 97.0
TLS2_k127_1937640_14 Outer membrane protein (OmpH-like) K06142 - - 0.000000000006767 75.0
TLS2_k127_1937640_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003438 307.0
TLS2_k127_1937640_3 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000002224 265.0
TLS2_k127_1937640_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003181 280.0
TLS2_k127_1937640_5 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000005768 259.0
TLS2_k127_1937640_6 Oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004202 255.0
TLS2_k127_1937640_7 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000001634 239.0
TLS2_k127_1937640_8 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000002616 208.0
TLS2_k127_1937640_9 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.0000000000000000000000000000000000000000000000000000000004367 232.0
TLS2_k127_194260_0 PFAM peptidase M14 carboxypeptidase A - - - 5.135e-244 779.0
TLS2_k127_194260_1 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001249 240.0
TLS2_k127_1944973_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000001183 230.0
TLS2_k127_1944973_1 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000001319 210.0
TLS2_k127_1944973_2 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000005909 191.0
TLS2_k127_1944973_3 glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000000000000000000000001057 201.0
TLS2_k127_1944973_4 glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000002576 197.0
TLS2_k127_1944973_5 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000002432 191.0
TLS2_k127_1944997_0 4Fe-4S dicluster domain K00184 - - 3.384e-321 1013.0
TLS2_k127_1944997_1 Polysulphide reductase, NrfD K00185 - - 1.711e-212 671.0
TLS2_k127_1944997_2 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 421.0
TLS2_k127_1944997_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000002097 224.0
TLS2_k127_1944997_4 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000000000000000000002167 195.0
TLS2_k127_1944997_5 signal sequence binding K07152 - - 0.000000000000001341 86.0
TLS2_k127_1944997_6 Cytochrome c7 and related cytochrome c - - - 0.000000000000007136 74.0
TLS2_k127_1944997_7 - - - - 0.000000002972 65.0
TLS2_k127_1957454_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001314 269.0
TLS2_k127_1957454_1 Haemolytic K08998 - - 0.000000000000000151 89.0
TLS2_k127_1957454_2 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000006335 66.0
TLS2_k127_1957454_3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0031123,GO:0031404,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 0.00000001063 63.0
TLS2_k127_1957454_5 single-stranded nucleic acid binding R3H K06346 - - 0.00004076 57.0
TLS2_k127_1959018_0 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000341 113.0
TLS2_k127_1959018_1 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000001234 117.0
TLS2_k127_1959018_2 Bacterial regulatory proteins, crp family K10914 - - 0.0000000249 67.0
TLS2_k127_1960088_0 PFAM Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 313.0
TLS2_k127_1960088_1 FAD binding domain - - - 0.0000000000000000000000000000000000000000225 160.0
TLS2_k127_1966957_0 phosphorelay signal transduction system K02481,K07713,K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 544.0
TLS2_k127_1966957_1 Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 505.0
TLS2_k127_1966957_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 345.0
TLS2_k127_1966957_3 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 331.0
TLS2_k127_1966957_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000765 229.0
TLS2_k127_1966957_5 Glycine cleavage H-protein - - - 0.000000000000000000000000000000000000000000000000000236 194.0
TLS2_k127_1966957_6 Peptidase family M54 K06974 - - 0.0000000000000000000000000000000000000003805 156.0
TLS2_k127_1966957_7 Glycine cleavage H-protein - - - 0.00000000000000000000005078 109.0
TLS2_k127_197188_0 PFAM MgtC SapB transporter K07507 - - 0.0000000000000000000000000001043 129.0
TLS2_k127_197188_1 PFAM Redoxin - - - 0.00000000000000002255 88.0
TLS2_k127_1973569_0 His Kinase A (phosphoacceptor) domain - - - 2.105e-227 769.0
TLS2_k127_1973569_1 DNA polymerase type-B family K02336 - 2.7.7.7 5.385e-198 645.0
TLS2_k127_1973569_2 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 541.0
TLS2_k127_1985070_0 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.000000000000000000000000000000004722 128.0
TLS2_k127_1985834_0 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 529.0
TLS2_k127_1987484_0 peptidyl-tyrosine sulfation - - - 1.569e-220 721.0
TLS2_k127_1987484_1 benzoyl-CoA reductase K04113 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007198 592.0
TLS2_k127_1987484_10 PFAM Uncharacterised protein family (UPF0150) - - - 0.00000000000003556 76.0
TLS2_k127_1987484_11 helix_turn_helix, Lux Regulon - - - 0.00000001832 56.0
TLS2_k127_1987484_12 CHAT domain - - - 0.00001247 53.0
TLS2_k127_1987484_2 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 474.0
TLS2_k127_1987484_3 Benzoyl-CoA reductase subunit K04114 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 450.0
TLS2_k127_1987484_4 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007655 380.0
TLS2_k127_1987484_5 Benzoyl-CoA reductase subunit K04115 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000001658 275.0
TLS2_k127_1987484_6 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000008758 219.0
TLS2_k127_1987484_7 PIN domain - - - 0.000000000000000000000000000000000000000000002921 180.0
TLS2_k127_1987484_8 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000000000000006408 94.0
TLS2_k127_1987484_9 peptidyl-tyrosine sulfation - - - 0.0000000000000000001069 105.0
TLS2_k127_1988699_0 Tricorn protease homolog - - - 0.0 1267.0
TLS2_k127_1988699_1 histidine kinase dimerisation and phosphoacceptor region K03406,K07673,K07675 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 418.0
TLS2_k127_1988699_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001201 294.0
TLS2_k127_1988699_3 Tetratricopeptide repeat - - - 0.00000000009323 74.0
TLS2_k127_2003737_0 6-phosphogluconolactonase activity - - - 0.0 1076.0
TLS2_k127_2003737_1 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004744 371.0
TLS2_k127_2007151_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006064 472.0
TLS2_k127_2007151_1 Binding-protein-dependent transport system inner membrane component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008494 389.0
TLS2_k127_2007151_2 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 345.0
TLS2_k127_2007151_3 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 314.0
TLS2_k127_2007151_4 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K11072 - 3.6.3.30,3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000817 277.0
TLS2_k127_2007151_5 arylsulfatase A - - - 0.0000000000000000000000000000005248 139.0
TLS2_k127_2007151_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000004038 114.0
TLS2_k127_2007151_7 4-amino-4-deoxy-L-arabinose transferase activity K02277 - 1.9.3.1 0.00000000005015 76.0
TLS2_k127_2012654_0 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 359.0
TLS2_k127_2012654_1 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.00000000000000000000000002236 112.0
TLS2_k127_2012654_2 Tetratricopeptide repeat - - - 0.000004329 57.0
TLS2_k127_2027090_0 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 510.0
TLS2_k127_2027090_1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000002752 261.0
TLS2_k127_2027090_2 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000002672 252.0
TLS2_k127_2027090_3 Protein conserved in bacteria - - - 0.0000000000000000000172 96.0
TLS2_k127_2027090_4 Sulfatase - - - 0.00000001012 66.0
TLS2_k127_2037063_0 peptidase K01278 - 3.4.14.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 352.0
TLS2_k127_2037063_1 PFAM Type II secretion system protein E K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 340.0
TLS2_k127_2037063_2 ATPase (AAA superfamily K07133 - - 0.00000000000000000000000000000000000000000000000000000001141 202.0
TLS2_k127_2038768_0 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000001745 119.0
TLS2_k127_2063536_0 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000614 346.0
TLS2_k127_2063536_1 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002655 245.0
TLS2_k127_2068682_0 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000876 171.0
TLS2_k127_2068682_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000004838 153.0
TLS2_k127_2068682_2 Fibronectin type 3 domain - - - 0.00000000000001479 78.0
TLS2_k127_2076034_0 PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000001802 94.0
TLS2_k127_2076034_1 Carboxypeptidase regulatory-like domain - - - 0.000000000000000001766 102.0
TLS2_k127_2076034_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00520 - 1.16.1.1 0.000000000006527 69.0
TLS2_k127_2076034_3 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.0000000002936 66.0
TLS2_k127_2076034_4 COG0464 ATPases of the AAA class - - - 0.00008055 46.0
TLS2_k127_2084665_0 PFAM Type II secretion system protein E K02652 - - 4.395e-225 709.0
TLS2_k127_2084665_1 PFAM Type II secretion system F domain K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003264 298.0
TLS2_k127_2084665_2 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000001126 261.0
TLS2_k127_2084665_3 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000175 195.0
TLS2_k127_2084665_4 ECF sigma factor K03088 - - 0.00000000000000000000008298 108.0
TLS2_k127_2084665_5 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000001961 101.0
TLS2_k127_2084665_6 Pilus assembly protein, PilO K02664 - - 0.0000000008476 68.0
TLS2_k127_2084665_7 Pilus assembly protein K02662 - - 0.0000206 56.0
TLS2_k127_2084665_8 PFAM Fimbrial assembly family protein K02663 - - 0.0006882 51.0
TLS2_k127_2087769_0 Thioesterase domain - - - 0.0 1263.0
TLS2_k127_2087769_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000002664 138.0
TLS2_k127_2087831_0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - 1.453e-284 901.0
TLS2_k127_2087831_1 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000000000000000007044 160.0
TLS2_k127_2089501_0 COG1555 DNA uptake protein and related DNA-binding proteins K02237 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000001309 72.0
TLS2_k127_2089501_1 Prokaryotic N-terminal methylation motif K08084 - - 0.0004214 50.0
TLS2_k127_2090559_0 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 322.0
TLS2_k127_2090559_1 TIGRFAM Phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000001734 231.0
TLS2_k127_2090559_2 FIST N domain - - - 0.00000000000000005781 93.0
TLS2_k127_2091077_0 Tricorn protease homolog K08676 - - 2.965e-228 737.0
TLS2_k127_2091077_1 pyrroloquinoline quinone binding - - - 0.000000000000005392 85.0
TLS2_k127_2098027_0 esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005481 409.0
TLS2_k127_2098027_1 anion-transporting ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000006041 234.0
TLS2_k127_2098027_2 PHB/PHA accumulation regulator DNA-binding domain - - - 0.000000000000000000000000000008539 124.0
TLS2_k127_2098027_3 Poly(hydroxyalcanoate) granule associated protein (phasin) - - - 0.000000000000004177 83.0
TLS2_k127_2099997_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 575.0
TLS2_k127_2099997_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 486.0
TLS2_k127_2099997_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 381.0
TLS2_k127_2099997_3 LVIVD repeat - - - 0.00000000000000000000000000000001855 146.0
TLS2_k127_2099997_4 Cytochrome c3 - - - 0.00000000000000000000000000000003081 143.0
TLS2_k127_2099997_5 - - - - 0.0000000000000001888 95.0
TLS2_k127_2109241_0 Enoyl-CoA hydratase/isomerase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.00000000000000000000000000000000000000000000000000002017 195.0
TLS2_k127_2109241_1 PFAM Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.000000000000000000000000000000000000000000003806 176.0
TLS2_k127_2110399_0 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004113 436.0
TLS2_k127_2110399_1 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004541 381.0
TLS2_k127_2110778_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00437,K05922,K06281 - 1.12.2.1,1.12.5.1,1.12.99.6 3.436e-278 863.0
TLS2_k127_2110778_1 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009429 503.0
TLS2_k127_2110778_10 Acetyltransferase (GNAT) domain - - - 0.000000000000009057 88.0
TLS2_k127_2110778_2 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282,K18008 - 1.12.2.1,1.12.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006154 501.0
TLS2_k127_2110778_3 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000774 432.0
TLS2_k127_2110778_4 PFAM Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003769 378.0
TLS2_k127_2110778_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 314.0
TLS2_k127_2110778_6 TIGRFAM Hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006636 312.0
TLS2_k127_2110778_7 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000001207 238.0
TLS2_k127_2110778_8 PFAM peptidase M52 hydrogen uptake protein K03605 - - 0.00000000000000000000000000000000003216 157.0
TLS2_k127_2110778_9 nickel cation binding K04651 - - 0.00000000000000000000000000000668 121.0
TLS2_k127_21163_0 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 603.0
TLS2_k127_21163_1 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005058 297.0
TLS2_k127_21163_2 Protein of unknown function (DUF3179) - - - 0.00000000000000000000000000000000000000000000000000000000000005238 224.0
TLS2_k127_21163_3 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000008879 157.0
TLS2_k127_21163_4 TIGRFAM VWFA-related Acidobacterial domain - - - 0.000000000000000000000000000000000003007 158.0
TLS2_k127_21163_5 TIGRFAM VWFA-related Acidobacterial domain - - - 0.000000000000000000000003003 119.0
TLS2_k127_21163_6 TPR repeat - - - 0.0000000000000000000000355 115.0
TLS2_k127_21163_7 TIGRFAM VWFA-related Acidobacterial domain - - - 0.0000000000000000001276 106.0
TLS2_k127_2119900_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 2.486e-313 1014.0
TLS2_k127_2119900_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 594.0
TLS2_k127_2119900_2 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003591 274.0
TLS2_k127_2119900_3 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002807 285.0
TLS2_k127_2119900_4 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000002132 246.0
TLS2_k127_2119900_5 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.000000000000000000000000000000000000000000000007296 181.0
TLS2_k127_2119900_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000003889 185.0
TLS2_k127_2119900_7 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000001954 143.0
TLS2_k127_21378_0 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 583.0
TLS2_k127_21378_1 Alpha/beta hydrolase family K07019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002848 283.0
TLS2_k127_21378_10 Domain of unknown function (DU1801) - - - 0.0000000249 67.0
TLS2_k127_21378_11 Transcriptional regulator, Crp Fnr family K01420,K10914 - - 0.000001105 51.0
TLS2_k127_21378_13 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0001966 51.0
TLS2_k127_21378_14 Domain of unknown function (DUF4143) K07133 - - 0.0002445 46.0
TLS2_k127_21378_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000135 276.0
TLS2_k127_21378_3 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000001741 220.0
TLS2_k127_21378_4 MOSC domain - - - 0.00000000000000000000000000000000000000000000003837 180.0
TLS2_k127_21378_5 Sigma-70 region 2 - - - 0.0000000000000000000000000000000005744 144.0
TLS2_k127_21378_6 Transglutaminase-like superfamily - - - 0.0000000000000000000000001098 124.0
TLS2_k127_21378_7 - - - - 0.0000000000000005025 81.0
TLS2_k127_21378_8 Domain of unknown function (DU1801) - - - 0.0000000000006878 70.0
TLS2_k127_214644_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 2.421e-253 824.0
TLS2_k127_214644_1 Predicted membrane protein (DUF2157) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007578 366.0
TLS2_k127_214644_2 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000005445 255.0
TLS2_k127_214644_3 Rubrerythrin K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000001407 258.0
TLS2_k127_214644_4 Belongs to the MraZ family K03925 - - 0.000000000000000000000000000000000000000007998 158.0
TLS2_k127_214644_5 PPIC-type PPIASE domain K03769,K07533 - 5.2.1.8 0.000000000000001968 88.0
TLS2_k127_214644_6 Domain of unknown function (DUF4824) - - - 0.000000000000221 83.0
TLS2_k127_214644_7 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.00000000003134 76.0
TLS2_k127_214644_8 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.00001072 49.0
TLS2_k127_2146484_0 Cytochrome c554 and c-prime - - - 2.274e-282 897.0
TLS2_k127_2146484_1 belongs to the thioredoxin family K03671,K05838 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 294.0
TLS2_k127_2146484_2 AAA domain (Cdc48 subfamily) K03544 - - 0.0000000000000000000000000004894 127.0
TLS2_k127_2146484_3 Glycosyl transferase family 41 - - - 0.000002621 59.0
TLS2_k127_2165260_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1065.0
TLS2_k127_2165471_0 Spermine/spermidine synthase domain - - - 5.154e-273 875.0
TLS2_k127_2165471_1 Glutamine cyclotransferase K00683 - 2.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000006753 242.0
TLS2_k127_2165471_2 PFAM KWG Leptospira repeat protein - - - 0.000000000000000000000000000000000000000000000000000001774 203.0
TLS2_k127_218574_0 HRDC domain protein K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 331.0
TLS2_k127_218574_1 Helix-hairpin-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001661 255.0
TLS2_k127_218574_2 Flavin reductase like domain - - - 0.0000000000000000000000002755 121.0
TLS2_k127_2189980_0 COGs COG1020 Non-ribosomal peptide synthetase modules and related protein - - - 0.0 1299.0
TLS2_k127_219890_0 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 353.0
TLS2_k127_219890_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K00087,K20447 - 1.17.1.4,1.17.1.5 0.0000000000000000000000000000000006646 133.0
TLS2_k127_219890_2 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000000009591 94.0
TLS2_k127_2199866_0 Sulfate ABC transporter, periplasmic sulfate-binding protein K02048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008559 455.0
TLS2_k127_2199866_1 Sulfate ABC transporter inner membrane subunit CysT K02046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004369 269.0
TLS2_k127_2199866_2 ATPase activity K02045 - 3.6.3.25 0.000000000000000000004181 98.0
TLS2_k127_2206579_0 Heat shock 70 kDa protein K04043 - - 2.469e-292 911.0
TLS2_k127_2206579_1 DNA-directed 5'-3' RNA polymerase activity K03043,K13797 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 331.0
TLS2_k127_2206579_10 Domain of unknown function (DUF1844) - - - 0.0000005509 60.0
TLS2_k127_2206579_11 SMART Tetratricopeptide domain protein - - - 0.0004577 53.0
TLS2_k127_2206579_2 MazG nucleotide pyrophosphohydrolase domain K04765 - 3.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000002895 244.0
TLS2_k127_2206579_3 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000003055 205.0
TLS2_k127_2206579_4 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000001002 184.0
TLS2_k127_2206579_5 IstB-like ATP binding protein K02315 - - 0.000000000000000000000000000000000000003584 158.0
TLS2_k127_2206579_6 Transcriptional regulator, MerR family K13640 GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000002815 125.0
TLS2_k127_2206579_7 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000001806 87.0
TLS2_k127_2206579_8 Domain of unknown function (DUF4388) - - - 0.00000000001649 78.0
TLS2_k127_2206579_9 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.0000000001368 63.0
TLS2_k127_2230218_0 PFAM Peptidase family M20 M25 M40 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 480.0
TLS2_k127_2230218_1 Highly conserved protein containing a thioredoxin domain K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008075 474.0
TLS2_k127_2230218_2 PFAM aminoglycoside phosphotransferase K07102 - 2.7.1.221 0.00000000000000000000000000000001094 143.0
TLS2_k127_2230218_3 CAAX protease self-immunity K07052 - - 0.00000000000000001606 87.0
TLS2_k127_2230218_4 PFAM Adenylate cyclase K05873 - 4.6.1.1 0.0000000000000007687 85.0
TLS2_k127_2235670_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000005542 244.0
TLS2_k127_2235670_1 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000007059 221.0
TLS2_k127_2243885_0 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000009682 262.0
TLS2_k127_2243885_1 Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000001702 126.0
TLS2_k127_2263812_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008661 307.0
TLS2_k127_2263812_1 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 308.0
TLS2_k127_2263812_10 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0005488,GO:0005507,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.0000000000000000000000000001846 124.0
TLS2_k127_2263812_11 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.000000000000000000000000005344 127.0
TLS2_k127_2263812_12 Phosphotransferase K07102 - 2.7.1.221 0.00000000000000000000005809 113.0
TLS2_k127_2263812_13 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000104 110.0
TLS2_k127_2263812_14 Belongs to the ompA family K03286 - - 0.00000000000000000001838 105.0
TLS2_k127_2263812_15 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000001952 96.0
TLS2_k127_2263812_16 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000000000002502 86.0
TLS2_k127_2263812_17 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000003449 63.0
TLS2_k127_2263812_18 response regulator K13599 - - 0.00006976 50.0
TLS2_k127_2263812_2 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 299.0
TLS2_k127_2263812_3 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009385 291.0
TLS2_k127_2263812_4 Cell division ATP-binding protein ftsE K09811,K09812 GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531 - 0.00000000000000000000000000000000000000000000000000000000000000000001487 241.0
TLS2_k127_2263812_5 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000002372 232.0
TLS2_k127_2263812_6 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.000000000000000000000000000000000000000000000000001232 192.0
TLS2_k127_2263812_7 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000001316 140.0
TLS2_k127_2263812_8 PFAM Lytic transglycosylase catalytic K08309 - - 0.000000000000000000000000000001353 132.0
TLS2_k127_2263812_9 positive regulation of growth rate - - - 0.00000000000000000000000000000523 134.0
TLS2_k127_2279652_0 Thiol disulfide interchange protein K04084 - 1.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 349.0
TLS2_k127_2281551_0 Helix-turn-helix domain - - - 0.0000000000000000000000003195 113.0
TLS2_k127_2281551_1 Pfam Activator of Hsp90 ATPase - - - 0.000000000000000006424 97.0
TLS2_k127_22921_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.00000000000000000000000000000000000000000000000000000000000000003374 234.0
TLS2_k127_22921_1 PFAM peptidase - - - 0.0000000000000000000000000000000000005104 152.0
TLS2_k127_229271_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 392.0
TLS2_k127_229271_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000006803 147.0
TLS2_k127_229524_0 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000003542 113.0
TLS2_k127_229524_1 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000004525 79.0
TLS2_k127_2309322_0 COG1020 Non-ribosomal peptide synthetase modules and related proteins K02364 - 6.3.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 549.0
TLS2_k127_2309322_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K04091 - 1.14.14.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 389.0
TLS2_k127_2309322_2 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 394.0
TLS2_k127_2309322_3 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 340.0
TLS2_k127_2309322_4 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 325.0
TLS2_k127_2309322_5 - - - - 0.00000000000000000001176 105.0
TLS2_k127_2309322_6 Glycosyl hydrolase family 20, catalytic domain protein K12373 - 3.2.1.52 0.000000000000001954 91.0
TLS2_k127_2326022_0 Proton-conducting membrane transporter K12137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005543 435.0
TLS2_k127_2326022_1 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005426 321.0
TLS2_k127_2326022_2 hydrogenase 4 membrane K12140 - - 0.00000000000000000000000000000000000002317 166.0
TLS2_k127_232750_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 2.612e-205 653.0
TLS2_k127_232750_1 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - 0.000000000000000000000000000000000001648 141.0
TLS2_k127_232750_2 Glycosyl transferase - - - 0.00000000000000000000003773 114.0
TLS2_k127_232750_3 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000008756 104.0
TLS2_k127_232750_4 TIGRFAM conserved repeat domain - - - 0.000000000000000001435 102.0
TLS2_k127_232750_6 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.000000000000003763 82.0
TLS2_k127_232750_7 Transglutaminase-like superfamily - - - 0.000000000008603 78.0
TLS2_k127_2342182_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007231 457.0
TLS2_k127_2342182_1 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 374.0
TLS2_k127_2342182_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008574 289.0
TLS2_k127_2342182_3 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000003241 81.0
TLS2_k127_2345776_0 Cellobiose phosphorylase K00702,K13688,K18675 - 2.4.1.20,2.4.1.280 0.0 2167.0
TLS2_k127_2345776_1 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 423.0
TLS2_k127_2345776_2 universal stress protein - - - 0.00000000000000000000000000000000000004547 156.0
TLS2_k127_2401133_0 Fumarase C C-terminus K01679 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 495.0
TLS2_k127_2401133_1 Carbamoyl-phosphate synthetase K01955 GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 407.0
TLS2_k127_2405943_0 Methylmalonyl-CoA mutase K11942 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046906,GO:0046983,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 523.0
TLS2_k127_2405943_1 formate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 505.0
TLS2_k127_2405943_2 Cytochrome b(N-terminal)/b6/petB K00410,K00412,K02635,K02637 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003871 424.0
TLS2_k127_2405943_3 NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 389.0
TLS2_k127_2405943_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005094 297.0
TLS2_k127_2405943_5 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000000000000000000000000002932 199.0
TLS2_k127_2405943_6 Rieske [2Fe-2S] domain K00411,K02636,K03886 - 1.10.2.2,1.10.9.1 0.0000000000000000000000000000000004785 136.0
TLS2_k127_244088_0 Proton-conducting membrane transporter K12141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 464.0
TLS2_k127_244088_1 hydrogenase 4 membrane K12140 - - 0.0000000000000000000000001018 107.0
TLS2_k127_244557_0 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002373 288.0
TLS2_k127_244557_1 esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002383 242.0
TLS2_k127_244557_2 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.0000000000000000000000000003161 119.0
TLS2_k127_2451179_0 Class III cytochrome C family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006621 304.0
TLS2_k127_2451179_1 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000003717 73.0
TLS2_k127_2451179_2 peptidyl-prolyl cis-trans isomerase activity K03769,K03771 - 5.2.1.8 0.00000002373 67.0
TLS2_k127_2451179_3 cAMP biosynthetic process K21008 - - 0.0000264 51.0
TLS2_k127_24589_0 asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 567.0
TLS2_k127_24589_1 geranylgeranyl reductase activity K14257 - 1.14.19.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 477.0
TLS2_k127_24589_2 Elongator protein 3, MiaB family, Radical SAM K06936 - - 0.000000000000000000000000000000000000000000000000000000000000000000009512 260.0
TLS2_k127_24589_3 Domain of unknown function (DUF4388) K12132 - 2.7.11.1 0.0000005313 61.0
TLS2_k127_2483891_0 General secretory system II, protein E domain protein K02454 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 609.0
TLS2_k127_2483891_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 472.0
TLS2_k127_2483891_2 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005003 412.0
TLS2_k127_2483891_3 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 400.0
TLS2_k127_2483891_4 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000001384 243.0
TLS2_k127_2483891_5 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000008288 218.0
TLS2_k127_2483891_6 spore germination K08978 - - 0.000000000000000000000000000000000000169 152.0
TLS2_k127_2483891_7 PFAM Peptidase family M23 K21471 - - 0.00000000000000000000000005693 124.0
TLS2_k127_2483891_8 Belongs to the UPF0337 (CsbD) family - - - 0.000000000000000000386 92.0
TLS2_k127_2483891_9 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.00000001322 67.0
TLS2_k127_2542115_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 419.0
TLS2_k127_2542115_1 Aminotransferase K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 410.0
TLS2_k127_2542115_2 Hydroxymethylglutaryl-coenzyme A reductase K00021 - 1.1.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003466 312.0
TLS2_k127_2542115_3 COG1233 Phytoene dehydrogenase and related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003521 266.0
TLS2_k127_2542115_4 Halogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004464 258.0
TLS2_k127_2542115_5 Retinal pigment epithelial membrane protein K00464,K11159 - 1.13.11.75 0.000000000000000000000000000000000000000005041 178.0
TLS2_k127_2542115_6 Beta-ketoacyl synthase, C-terminal domain - - - 0.000000000000000000000000000000000000004915 167.0
TLS2_k127_2542115_7 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00008835 48.0
TLS2_k127_25578_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 298.0
TLS2_k127_25578_1 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000001252 155.0
TLS2_k127_25578_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000002949 83.0
TLS2_k127_25578_3 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000644 61.0
TLS2_k127_256006_0 Belongs to the ClpA ClpB family K03694 - - 8.571e-258 822.0
TLS2_k127_256006_1 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 2.765e-257 818.0
TLS2_k127_256006_2 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000006411 115.0
TLS2_k127_256006_3 HRDC domain protein K03684 - 3.1.13.5 0.000000008293 61.0
TLS2_k127_2560259_0 WD40-like Beta Propeller Repeat - - - 9.769e-277 886.0
TLS2_k127_2560259_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000005521 176.0
TLS2_k127_2560259_2 growth of symbiont in host cell K07003 - - 0.000000000000000000000000000000000000000004482 162.0
TLS2_k127_2564180_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 331.0
TLS2_k127_2564180_1 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 334.0
TLS2_k127_2564180_10 Tetratricopeptide repeat - - - 0.0004258 52.0
TLS2_k127_2564180_2 transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004268 298.0
TLS2_k127_2564180_3 bacteriocin transport K03561 - - 0.000000000000000000000000000000000000000000000009213 181.0
TLS2_k127_2564180_4 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000002119 138.0
TLS2_k127_2564180_5 phosphorelay signal transduction system - - - 0.0000000000000000000000002441 116.0
TLS2_k127_2564180_6 Gram-negative bacterial TonB protein C-terminal - - - 0.0000000000000000000192 100.0
TLS2_k127_2564180_7 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.0000000000000003712 83.0
TLS2_k127_2564180_9 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.0000001432 59.0
TLS2_k127_2564491_0 Elongator protein 3, MiaB family, Radical SAM - - - 8.366e-212 671.0
TLS2_k127_2564491_1 phosphoesterase, PA-phosphatase related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 575.0
TLS2_k127_2564491_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000001869 277.0
TLS2_k127_2564491_3 Methyltransferase domain - - - 0.00000001466 68.0
TLS2_k127_2564491_4 Domain of unknown function (DUF1842) - - - 0.000000273 57.0
TLS2_k127_257209_0 Peptidase family M28 - - - 3.367e-302 952.0
TLS2_k127_257209_1 Domain of unknown function (DUF4143) K07133 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 483.0
TLS2_k127_257209_2 - - - - 0.00002278 48.0
TLS2_k127_2584147_0 Di- and tricarboxylate transporters - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002627 443.0
TLS2_k127_2584147_1 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000006349 116.0
TLS2_k127_2584147_2 PFAM O-methyltransferase - - - 0.00000000000008522 82.0
TLS2_k127_2589327_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005217 506.0
TLS2_k127_2589327_1 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000002454 104.0
TLS2_k127_2589327_2 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000001072 78.0
TLS2_k127_2589327_3 DNA polymerase III, delta' K02340 - 2.7.7.7 0.00007569 55.0
TLS2_k127_261218_0 B12 binding domain K00548 - 2.1.1.13 9.4e-323 1008.0
TLS2_k127_261218_1 methylenetetrahydrofolate reductase (NAD(P)H) activity K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 443.0
TLS2_k127_261218_2 sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000002773 220.0
TLS2_k127_261218_3 -O-antigen K02847 - - 0.000000003706 70.0
TLS2_k127_261218_4 VanZ like family - - - 0.0000733 53.0
TLS2_k127_261218_5 Glycosyl transferase family 41 K09667 - 2.4.1.255 0.0001075 55.0
TLS2_k127_2635133_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000001678 149.0
TLS2_k127_2635133_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000005082 94.0
TLS2_k127_2635133_2 O-linked N-acetylglucosamine transferase, SPINDLY family - - - 0.000000000000001368 91.0
TLS2_k127_26563_0 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000008475 224.0
TLS2_k127_26563_1 PFAM Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000007144 161.0
TLS2_k127_26563_2 PFAM PKD domain containing protein - - - 0.0004618 50.0
TLS2_k127_2659769_0 COG1899 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 433.0
TLS2_k127_2659769_1 PFAM HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000002037 231.0
TLS2_k127_2659769_2 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07714 - - 0.00000000000000000000000000000000000000000000000000000000000001158 232.0
TLS2_k127_2659769_3 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000002248 124.0
TLS2_k127_2659769_4 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000002973 121.0
TLS2_k127_2683356_0 PFAM Glycoside hydrolase 15-related - - - 4.415e-249 805.0
TLS2_k127_268457_0 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 454.0
TLS2_k127_268457_1 C-5 cytosine-specific DNA methylase K00558 - 2.1.1.37 0.000000000000000000002541 97.0
TLS2_k127_269902_0 POT family K03305 - - 2.724e-207 660.0
TLS2_k127_269902_1 Glycosyl transferase 4-like K00754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 411.0
TLS2_k127_269902_2 Bacillithiol biosynthesis BshC K22136 - - 0.000000000000000000000000000000000000000000000004095 190.0
TLS2_k127_269902_3 PFAM GlcNAc-PI de-N-acetylase K01463 - - 0.00000000000000000000000000000000000000000004454 183.0
TLS2_k127_269902_4 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000001749 179.0
TLS2_k127_269902_5 Uncharacterized protein family UPF0029 - - - 0.00000000000000000000000000001762 136.0
TLS2_k127_269902_6 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000003902 73.0
TLS2_k127_2750821_2 domain protein K14194 - - 0.000307 55.0
TLS2_k127_2753592_0 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 394.0
TLS2_k127_2753592_1 ATPase activity K02045 - 3.6.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000007278 249.0
TLS2_k127_2799823_0 DEAD DEAH box helicase K06877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 336.0
TLS2_k127_2799823_1 Cyclase dehydrase - - - 0.0000000000000000000000000000000000000000000000000001858 188.0
TLS2_k127_2808381_0 Mo-co oxidoreductase dimerisation domain - - - 0.0000000000000000000000000000000000000000000001919 170.0
TLS2_k127_2808381_1 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000000004619 164.0
TLS2_k127_2808381_2 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.0001373 48.0
TLS2_k127_2809208_0 Sortilin, neurotensin receptor 3, - - - 0.0 1074.0
TLS2_k127_2815392_0 Tricorn protease homolog K08676 - - 0.0 1084.0
TLS2_k127_2816697_0 Uncharacterised protein family (UPF0182) K09118 - - 7.549e-306 960.0
TLS2_k127_2816697_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.541e-254 798.0
TLS2_k127_2818191_0 Exodeoxyribonuclease IX - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005215 279.0
TLS2_k127_2818191_1 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000002986 155.0
TLS2_k127_2818191_2 Alpha beta hydrolase fold protein - - - 0.000000000000000000000000000000001439 136.0
TLS2_k127_2819302_0 R3H domain - - - 1.466e-195 627.0
TLS2_k127_2819302_1 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009112 291.0
TLS2_k127_2819302_2 Predicted membrane protein (DUF2339) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000712 294.0
TLS2_k127_2819302_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000007805 209.0
TLS2_k127_2819302_4 DoxX-like family - - - 0.000000000000000000000000000000001289 136.0
TLS2_k127_2819302_5 Protein of unknown function (DUF3999) - - - 0.0000000000000000000000000000006912 141.0
TLS2_k127_2819302_6 YjbR - - - 0.0000000000000000000000000001146 118.0
TLS2_k127_2823007_0 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000091 317.0
TLS2_k127_2829362_0 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006211 473.0
TLS2_k127_2840392_0 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 355.0
TLS2_k127_2840392_1 2-oxoglutarate dehydrogenase, E1 K00164 - 1.2.4.2 0.0000000000000000007769 90.0
TLS2_k127_2843282_0 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000001856 87.0
TLS2_k127_2843282_1 Rieske (2fe-2S) K00499 - 1.14.15.7 0.0000000000001126 71.0
TLS2_k127_2846277_0 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 423.0
TLS2_k127_2846277_1 Belongs to the CarA family K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005568 372.0
TLS2_k127_2846277_2 Conserved hypothetical ATP binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 333.0
TLS2_k127_2846277_3 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003152 259.0
TLS2_k127_2846277_4 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000001291 215.0
TLS2_k127_2846277_5 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000000000000000000000000000002715 216.0
TLS2_k127_2846277_6 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000000000000003665 164.0
TLS2_k127_2846277_7 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000002184 88.0
TLS2_k127_2848572_0 Carboxyl transferase domain - - - 3.006e-205 656.0
TLS2_k127_2848572_1 Molybdopterin converting factor subunit K03635,K21142 - 2.8.1.12 0.00000000000000000000000000000000000000000000002927 184.0
TLS2_k127_2848572_2 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.0000000006008 69.0
TLS2_k127_2848572_3 - - - - 0.000000000826 72.0
TLS2_k127_2848572_4 - - - - 0.00001266 56.0
TLS2_k127_2848646_0 Rieske (2fe-2S) K00499 - 1.14.15.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005365 478.0
TLS2_k127_2848646_1 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000006014 124.0
TLS2_k127_2851438_0 Belongs to the carbamoyltransferase HypF family K04656 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 540.0
TLS2_k127_2851438_1 HupF/HypC family K04653 - - 0.000000000000000000003839 93.0
TLS2_k127_2855605_0 Dipeptidyl peptidase IV (DPP IV) N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 445.0
TLS2_k127_2855605_1 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 - 3.6.3.29 0.00000000000000000000000000000000000000000000000002013 190.0
TLS2_k127_2856007_0 calcium- and calmodulin-responsive adenylate cyclase activity - - - 8.442e-201 647.0
TLS2_k127_2856007_1 PFAM peptidase M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 370.0
TLS2_k127_2862299_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 1.73e-197 636.0
TLS2_k127_2862299_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000005036 213.0
TLS2_k127_2862299_2 ECF sigma factor - - - 0.000000000000000000000000000000002469 147.0
TLS2_k127_2862299_3 - - - - 0.0000000000000000000000008764 119.0
TLS2_k127_2862299_4 outer membrane efflux protein K15725 - - 0.0000000001384 74.0
TLS2_k127_2862299_5 Domain of unknown function (DUF4349) - - - 0.0000002402 60.0
TLS2_k127_2864909_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 3.662e-275 854.0
TLS2_k127_2864909_1 Domain of unknown function (DUF3536) - - - 5.105e-261 840.0
TLS2_k127_2864909_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003835 271.0
TLS2_k127_2864909_3 Cupin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004642 254.0
TLS2_k127_2868728_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007418 516.0
TLS2_k127_2868728_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000008708 206.0
TLS2_k127_2868728_2 Domain of unknown function (DUF4126) - - - 0.0000000000000000000000000000000000000000000001785 174.0
TLS2_k127_2868728_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000006579 188.0
TLS2_k127_2868728_4 Hydantoinase/oxoprolinase K01469,K01473 - 3.5.2.14,3.5.2.9 0.00000000000000000000000000000000000000000005061 166.0
TLS2_k127_2868728_5 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.00000000000000000000000000000000000000000007016 161.0
TLS2_k127_2868728_6 SpoU rRNA Methylase family K03437 - - 0.00000000000000000000000000000000005877 156.0
TLS2_k127_2876137_0 Domain of unknown function (DUF4915) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003962 317.0
TLS2_k127_2876137_1 nucleotidyltransferase activity K07075 - - 0.000000000000000000000000000005977 126.0
TLS2_k127_2876137_2 Domain of unknown function (DUF4258) - - - 0.0000000001326 72.0
TLS2_k127_2876484_0 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000002675 195.0
TLS2_k127_2876484_1 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000009514 145.0
TLS2_k127_2876484_2 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000000000000000000001054 112.0
TLS2_k127_2876484_3 self proteolysis - - - 0.0001159 55.0
TLS2_k127_2881943_0 PFAM AMP-dependent synthetase and ligase K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 420.0
TLS2_k127_2881943_1 positive regulation of growth - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.000000998 58.0
TLS2_k127_2885429_0 PAS domain K13924 - 2.1.1.80,3.1.1.61 9.193e-240 792.0
TLS2_k127_2885429_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004017 448.0
TLS2_k127_2885429_2 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000001682 239.0
TLS2_k127_2885429_3 Belongs to the pseudouridine synthase RsuA family K06178,K06182 - 5.4.99.21,5.4.99.22 0.000000000000000000000000000000000000000000000000000009801 208.0
TLS2_k127_2885429_4 proteins, homologs of microcin C7 resistance protein MccF K01297 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009050,GO:0009056,GO:0009254,GO:0009987,GO:0016787,GO:0019538,GO:0030203,GO:0034641,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.4.17.13 0.0000000000000000000000000000000000000000000000000002419 197.0
TLS2_k127_2885429_5 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000001807 187.0
TLS2_k127_2885429_6 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000009601 175.0
TLS2_k127_2885429_7 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000698 165.0
TLS2_k127_2885429_8 histone H2A K63-linked ubiquitination K10914 - - 0.0000000000000000000000000000000002087 142.0
TLS2_k127_2885880_0 Two component signalling adaptor domain K03407,K13490 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006455 322.0
TLS2_k127_2885880_1 protein-glutamate methylesterase activity K03412,K03413 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000001001 248.0
TLS2_k127_2885880_2 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000006702 219.0
TLS2_k127_2885880_3 chemotaxis K03406 - - 0.00000000000000000000000000000000000000000000000385 194.0
TLS2_k127_2885880_4 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000001186 179.0
TLS2_k127_2885880_5 Methylase of chemotaxis methyl-accepting K00575 - 2.1.1.80 0.000000004029 69.0
TLS2_k127_2885880_6 Two component signalling adaptor domain K03408 - - 0.00007809 55.0
TLS2_k127_2885891_0 transferase activity, transferring acyl groups K14658,K17840,K18815 - 2.3.1.59,2.3.1.82 0.00000000000000000000000000000000000000000000000000000000002327 227.0
TLS2_k127_2892055_0 Protein of unknown function (DUF1223) - - - 0.00000000000000000000000000000000000000003016 162.0
TLS2_k127_2892055_1 Heat shock 70 kDa protein - - - 0.0000000000002508 78.0
TLS2_k127_28923_0 Cytochrome C assembly protein K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 484.0
TLS2_k127_28923_1 Cytochrome c assembly protein K02195 - - 0.0000000000000000000000000000000000000000000000000000005998 201.0
TLS2_k127_28923_2 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000005006 125.0
TLS2_k127_28923_3 ABC-type transport system involved in cytochrome c biogenesis permease component K02194 - - 0.00001617 50.0
TLS2_k127_28923_4 Metallophosphoesterase K01090 - 3.1.3.16 0.0000395 46.0
TLS2_k127_290910_0 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008209 309.0
TLS2_k127_290910_1 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000004814 122.0
TLS2_k127_2912091_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000005607 96.0
TLS2_k127_2912091_1 phosphoserine phosphatase activity K07052,K07315 - 3.1.3.3 0.00000000000000000007864 104.0
TLS2_k127_2917437_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1203.0
TLS2_k127_2917437_1 PFAM multicopper oxidase type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 406.0
TLS2_k127_2917437_10 Thioredoxin-like - - - 0.00000000000000000005638 105.0
TLS2_k127_2917437_11 transcriptional regulator K21903 - - 0.0000000000000002443 83.0
TLS2_k127_2917437_12 - K14588 - - 0.0001254 50.0
TLS2_k127_2917437_2 transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 340.0
TLS2_k127_2917437_3 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001593 256.0
TLS2_k127_2917437_4 iron dependent repressor K03709 - - 0.00000000000000000000000000000000000000000000000000000000000002474 221.0
TLS2_k127_2917437_5 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000004116 186.0
TLS2_k127_2917437_6 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000002661 183.0
TLS2_k127_2917437_7 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000001679 175.0
TLS2_k127_2917437_8 Putative restriction endonuclease - - - 0.00000000000000000000000000000001114 141.0
TLS2_k127_2917437_9 Transglutaminase-like superfamily - - - 0.000000000000000000000000000001727 138.0
TLS2_k127_2923980_0 OPT oligopeptide transporter protein - GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - 8.413e-252 797.0
TLS2_k127_2923980_1 Cleaves the N-terminal amino acid of tripeptides K01270 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008987 409.0
TLS2_k127_2923980_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000006789 267.0
TLS2_k127_2923980_3 Deoxynucleoside kinase K15518 - 2.7.1.113 0.000000000000000000000000000000000000000000000000000007361 197.0
TLS2_k127_2927974_0 PFAM surface antigen (D15) K07277,K07278 - - 0.00000000000000000000000007491 116.0
TLS2_k127_2927974_1 PIN domain K18828 - - 0.000000000000000004566 92.0
TLS2_k127_2927974_2 Tetratricopeptide repeat - - - 0.000001158 59.0
TLS2_k127_2931847_0 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 398.0
TLS2_k127_2931847_1 von Willebrand factor, type A K07114 - - 0.000000004671 67.0
TLS2_k127_2936349_0 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 544.0
TLS2_k127_2936349_1 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005312 378.0
TLS2_k127_2936349_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 351.0
TLS2_k127_2936349_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 357.0
TLS2_k127_2936349_4 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 333.0
TLS2_k127_2936349_5 3-demethylubiquinone-9 3-O-methyltransferase activity K15257,K18534 - 2.1.1.295 0.000000000000000000000000000000000000000000001935 179.0
TLS2_k127_2936349_6 ASPIC and UnbV - - - 0.0000000000000000000000000004854 119.0
TLS2_k127_2936349_7 Tetratricopeptide repeat - - - 0.000000003263 70.0
TLS2_k127_2936349_8 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.000000004199 69.0
TLS2_k127_2936349_9 PFAM Tetratricopeptide repeat - - - 0.00000009978 64.0
TLS2_k127_2937089_0 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases K00174 - 1.2.7.11,1.2.7.3 2.465e-237 748.0
TLS2_k127_2942910_0 Two component, sigma54 specific, transcriptional regulator, Fis family K07712 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000253 292.0
TLS2_k127_2942910_1 WD-40 repeat - - - 0.000000000000000000000000000000000000000000000000000002962 205.0
TLS2_k127_2946038_0 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.00000000000000000000000000000000000000000000000000000001662 211.0
TLS2_k127_2946038_1 Enoyl-CoA hydratase/isomerase K07539 - 3.7.1.21 0.00000000000000000000004124 101.0
TLS2_k127_2946038_2 Bacterial regulatory proteins, tetR family - - - 0.000000002141 70.0
TLS2_k127_2959326_0 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 411.0
TLS2_k127_2959326_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005796 293.0
TLS2_k127_2961305_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 616.0
TLS2_k127_2961305_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K04127,K11325,K21174 - 5.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005829 453.0
TLS2_k127_2961305_2 Predicted membrane protein (DUF2142) - - - 0.000000000000000000000000000000000000000000000000000008607 207.0
TLS2_k127_2961305_3 - - - - 0.000000000003757 79.0
TLS2_k127_2964101_0 WD40 repeats K20332 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 518.0
TLS2_k127_2964101_1 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009253 434.0
TLS2_k127_2968229_0 Methyl-accepting chemotaxis protein (MCP) signaling domain K02660 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 319.0
TLS2_k127_2968229_1 cheY-homologous receiver domain K02658 - - 0.000000000000000000000000000000000002179 143.0
TLS2_k127_2968229_2 Two component signalling adaptor domain K02487,K06596 - - 0.0000000000000007879 92.0
TLS2_k127_2968229_3 Belongs to the Dps family K04047 - - 0.000000000009747 68.0
TLS2_k127_2968229_4 Chemotaxis protein cheW K03408 - - 0.000003616 57.0
TLS2_k127_2968940_0 Carbamoyltransferase K00612 - - 0.000000000000000000000000000000000000000005071 158.0
TLS2_k127_2968940_1 - - - - 0.000000000000000000000000000000000003141 158.0
TLS2_k127_2977831_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 6.243e-234 746.0
TLS2_k127_2988143_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 6.965e-264 831.0
TLS2_k127_2988143_1 PFAM multicopper oxidase type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 332.0
TLS2_k127_2988143_2 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000004292 188.0
TLS2_k127_2988143_3 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000002216 149.0
TLS2_k127_2999794_0 Acyl-CoA dehydrogenase, N-terminal domain K00248,K00249 - 1.3.8.1,1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 375.0
TLS2_k127_2999794_1 acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.0000000000000000000000004102 106.0
TLS2_k127_2999794_2 PFAM Squalene phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000006929 96.0
TLS2_k127_2999794_3 Transcription factor zinc-finger - - - 0.0000000000000009455 85.0
TLS2_k127_2999794_4 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.000000000003411 72.0
TLS2_k127_3005556_0 ABC1 family K03688 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004919 549.0
TLS2_k127_3005556_1 Phosphate acyltransferases - - - 0.000000004128 64.0
TLS2_k127_3009320_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 2.917e-213 700.0
TLS2_k127_3009320_1 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 443.0
TLS2_k127_3009320_2 PIN domain K07064 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000007302 206.0
TLS2_k127_3009320_3 Inner membrane component domain - - - 0.000000000000000000000000000000000000009105 149.0
TLS2_k127_3009320_4 - - GO:0008150,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 - 0.000000000000000000000000827 105.0
TLS2_k127_3009320_5 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000003885 65.0
TLS2_k127_3010306_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 2.798e-271 861.0
TLS2_k127_3010306_1 (ABC) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 435.0
TLS2_k127_3010306_2 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 298.0
TLS2_k127_3010306_3 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000001127 185.0
TLS2_k127_3010306_4 response regulator - - - 0.0000000000000000000000001517 118.0
TLS2_k127_3010306_5 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000002916 106.0
TLS2_k127_3010306_6 outer membrane autotransporter barrel domain protein - - - 0.00000001595 64.0
TLS2_k127_3010633_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001273 254.0
TLS2_k127_3010633_1 Binds the 23S rRNA K02909 - - 0.000000000000000000000006439 103.0
TLS2_k127_3011699_0 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000005457 169.0
TLS2_k127_3011699_1 DinB family - - - 0.00000000000000000000000000000000000002052 149.0
TLS2_k127_3011699_2 - - - - 0.00001786 52.0
TLS2_k127_3013015_0 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 377.0
TLS2_k127_3013015_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 331.0
TLS2_k127_3013015_3 Belongs to the DegT DnrJ EryC1 family K13310 - 2.6.1.106 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007187 314.0
TLS2_k127_3013015_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000002297 237.0
TLS2_k127_3013015_5 lysyltransferase activity K07027 - - 0.0000000000000000000000000000000003785 151.0
TLS2_k127_3013015_6 UbiA prenyltransferase family - - - 0.000000000000000000000000000004425 121.0
TLS2_k127_3013015_7 ATP hydrolysis coupled proton transport - - - 0.0000000000000000000000000002201 132.0
TLS2_k127_3053658_0 Adenylate and Guanylate cyclase catalytic domain - - - 7.867e-207 704.0
TLS2_k127_3053658_1 TonB dependent receptor K02014,K16089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 526.0
TLS2_k127_3053658_2 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000614 418.0
TLS2_k127_3053658_3 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K17837 - 3.5.2.6 0.00000000000000000000000000000000000000001281 171.0
TLS2_k127_3053658_4 Domain of unknown function (DUF4154) - - - 0.000000000000000000002552 110.0
TLS2_k127_3057198_0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 334.0
TLS2_k127_3057198_1 signal transduction histidine kinase K13587 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000009699 279.0
TLS2_k127_3057198_2 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000004102 220.0
TLS2_k127_3057198_3 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.000000000000000000000000000002578 122.0
TLS2_k127_3058392_0 Dienelactone hydrolase family - - - 1.379e-216 697.0
TLS2_k127_3058392_1 Penicillin amidase K01434,K07116 - 3.5.1.11,3.5.1.97 0.000000000000000000000006686 103.0
TLS2_k127_3058842_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 349.0
TLS2_k127_3058842_1 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 325.0
TLS2_k127_3058842_2 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000008824 145.0
TLS2_k127_3058842_3 Transport permease protein - - - 0.000000000000000000000000000000002404 148.0
TLS2_k127_3058842_4 Proto-chlorophyllide reductase 57 kd subunit - - - 0.000000000000000008566 88.0
TLS2_k127_3058842_5 Adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000001168 59.0
TLS2_k127_3060903_0 DEAD DEAH box K03724 - - 0.00000000000000000000000000000000000000000000000000000000000005362 222.0
TLS2_k127_3060903_1 Dehydrogenase E1 component K00615 - 2.2.1.1 0.0000000000000000000000000000000000001519 151.0
TLS2_k127_3060903_2 Protein of unknown function (DUF493) - - - 0.000000000000002167 85.0
TLS2_k127_3060918_0 DEAD DEAH box K03724 - - 0.0000000000000000000000000000000000000000000000000000000000003522 220.0
TLS2_k127_3060918_1 Dehydrogenase E1 component K00615 - 2.2.1.1 0.000000000000000000000000000000000000005731 151.0
TLS2_k127_3060918_2 Protein of unknown function (DUF493) - - - 0.0000000000000167 85.0
TLS2_k127_3066627_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1439.0
TLS2_k127_3066627_1 X-Pro dipeptidyl-peptidase (S15 family) - - - 1.784e-205 662.0
TLS2_k127_3066627_2 response regulator K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005682 448.0
TLS2_k127_3066627_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.00000000000000000000000000000000000000000000000000000000000000000003522 238.0
TLS2_k127_3081772_0 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009539 622.0
TLS2_k127_3081772_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 589.0
TLS2_k127_3081772_10 Iron-sulfur cluster-binding domain - - - 0.000002799 61.0
TLS2_k127_3081772_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004476 428.0
TLS2_k127_3081772_3 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006372 408.0
TLS2_k127_3081772_4 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008878 343.0
TLS2_k127_3081772_5 Two component transcriptional regulator, winged helix family K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001901 253.0
TLS2_k127_3081772_6 Fructosamine kinase - - - 0.000000000000000000000000000000000000000000000000000000000009318 213.0
TLS2_k127_3081772_7 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000004652 160.0
TLS2_k127_3081772_8 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000001591 102.0
TLS2_k127_3081772_9 PFAM Uncharacterised protein family UPF0175 - - - 0.0000000000000000003366 94.0
TLS2_k127_3089639_0 His Kinase A (phosphoacceptor) domain K07641,K10819 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 494.0
TLS2_k127_3089639_1 Two component transcriptional regulator, winged helix family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007805 282.0
TLS2_k127_3089639_2 Protein of unknown function (DUF3800) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001631 273.0
TLS2_k127_3089639_3 Putative molybdenum carrier - - - 0.0000000000000000000000000002306 131.0
TLS2_k127_3089639_4 transposase or invertase - - - 0.0000000004851 63.0
TLS2_k127_3093502_0 Lantibiotic biosynthesis dehydratase C-term K20483 - - 1.992e-294 958.0
TLS2_k127_3093502_1 ABC transporter - - - 3.307e-198 660.0
TLS2_k127_3093502_10 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002628 295.0
TLS2_k127_3093502_11 Lanthionine synthetase C-like protein K20484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009134 282.0
TLS2_k127_3093502_12 TrkA-N domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006335 261.0
TLS2_k127_3093502_13 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000004974 242.0
TLS2_k127_3093502_14 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000007637 208.0
TLS2_k127_3093502_15 abc transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000006089 196.0
TLS2_k127_3093502_16 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000004378 170.0
TLS2_k127_3093502_17 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000001075 158.0
TLS2_k127_3093502_18 NUDIX domain K01515 - 3.6.1.13 0.000000000000000000000000000000006647 134.0
TLS2_k127_3093502_19 Haloacid dehalogenase-like hydrolase K07025 - - 0.00000000000000000000000000000005626 145.0
TLS2_k127_3093502_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 507.0
TLS2_k127_3093502_20 - - - - 0.00000000000000000000002066 105.0
TLS2_k127_3093502_21 transcriptional regulator, Rrf2 family - - - 0.00000000000000000000005095 103.0
TLS2_k127_3093502_3 PFAM Patatin-like phospholipase K06900 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 407.0
TLS2_k127_3093502_4 Sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 402.0
TLS2_k127_3093502_5 PFAM cation transporter K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 394.0
TLS2_k127_3093502_6 tryptophan 2,3-dioxygenase activity K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 350.0
TLS2_k127_3093502_7 Cation transport protein K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004558 351.0
TLS2_k127_3093502_8 Lanthionine synthetase C-like protein K20484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 308.0
TLS2_k127_3093502_9 Domain of unknown function (DUF1972) K12996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002583 284.0
TLS2_k127_3101629_0 TonB-dependent Receptor Plug Domain K02014 - - 1.107e-206 670.0
TLS2_k127_3101629_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 481.0
TLS2_k127_3101629_2 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 315.0
TLS2_k127_3101629_3 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000001786 162.0
TLS2_k127_3101629_4 Bacterial regulatory proteins, tetR family - - - 0.00000000001787 73.0
TLS2_k127_3113447_0 Part of a membrane complex involved in electron transport K03615 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007561 416.0
TLS2_k127_3113447_1 Part of a membrane complex involved in electron transport K03614 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 325.0
TLS2_k127_3113447_2 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00171,K00172,K02573,K03737,K13795,K18930 - 1.2.7.1 0.000000004088 63.0
TLS2_k127_3127903_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 314.0
TLS2_k127_3136069_0 Psort location CytoplasmicMembrane, score 10.00 K03458 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 505.0
TLS2_k127_3136069_1 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006456 394.0
TLS2_k127_3136069_2 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007216 407.0
TLS2_k127_3136069_3 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000001595 233.0
TLS2_k127_3136069_4 PFAM carbon monoxide dehydrogenase subunit G K09386 - - 0.0000000000000000000000000000000003107 146.0
TLS2_k127_3136069_5 Transcriptional regulator PadR-like family - - - 0.0000000000000003783 82.0
TLS2_k127_3136069_6 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000005356 55.0
TLS2_k127_3144587_0 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008811 380.0
TLS2_k127_3144587_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006806 383.0
TLS2_k127_3144587_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000001284 267.0
TLS2_k127_3144587_3 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000001139 237.0
TLS2_k127_3144587_4 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000001025 189.0
TLS2_k127_3144587_5 Peptidase C26 K07010 - - 0.0000000000000000000000000000000008592 143.0
TLS2_k127_3144587_6 - - - - 0.00000000000000000000000000000005025 134.0
TLS2_k127_3144587_7 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.00000000000001774 74.0
TLS2_k127_3144587_8 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.00000003341 56.0
TLS2_k127_31527_0 self proteolysis - - - 0.000000000000000000000001886 106.0
TLS2_k127_31527_1 Belongs to the peptidase S8 family K14645 GO:0005575,GO:0005576 - 0.0005042 52.0
TLS2_k127_3158800_0 glycosyl hydrolase, BNR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007588 460.0
TLS2_k127_3158800_1 PFAM ABC transporter related K02193 - 3.6.3.41 0.00000000000000000000000000000000001123 147.0
TLS2_k127_3158800_2 PFAM cytochrome c-type biogenesis protein CcmB K02194 - - 0.0000000000000000000000000001178 125.0
TLS2_k127_3160179_0 ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component K02004 - - 0.000000000000000000000000000000000004904 145.0
TLS2_k127_3160179_1 Bacterial membrane protein, YfhO - - - 0.000000000000000001047 102.0
TLS2_k127_316868_0 exo-alpha-(2->6)-sialidase activity - - - 0.0004923 54.0
TLS2_k127_3169705_0 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004555 529.0
TLS2_k127_3169705_1 Zn_pept - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 482.0
TLS2_k127_3169705_2 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000659 126.0
TLS2_k127_3169705_3 PFAM peptidase M14 carboxypeptidase A - - - 0.0000000001227 72.0
TLS2_k127_3175978_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0 1138.0
TLS2_k127_3175978_1 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005947 454.0
TLS2_k127_3175978_2 Tetratricopeptide repeat - - - 0.0000000000007074 76.0
TLS2_k127_3190380_0 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 535.0
TLS2_k127_3190380_1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009444 371.0
TLS2_k127_3190380_2 PFAM ROK family protein K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000009306 256.0
TLS2_k127_3190380_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K13810 - 2.2.1.2,5.3.1.9 0.000006058 51.0
TLS2_k127_3200781_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01657,K02500 GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004603 299.0
TLS2_k127_3200781_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006352 297.0
TLS2_k127_3200781_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769 2.6.1.9 0.000000000000000000000000000000000000000000000000002954 207.0
TLS2_k127_3200781_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000002118 196.0
TLS2_k127_3200781_4 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000002639 197.0
TLS2_k127_3200781_5 Histidine biosynthesis bifunctional protein hisIE K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000003986 145.0
TLS2_k127_3200781_6 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765,K02502 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000007315 148.0
TLS2_k127_3200781_7 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.000000000000000000000000000000004573 139.0
TLS2_k127_3202557_0 Polysaccharide biosynthesis protein K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005785 471.0
TLS2_k127_3202557_1 PFAM Peptidase family M20 M25 M40 K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 406.0
TLS2_k127_3208704_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 374.0
TLS2_k127_3208704_1 TIGRFAM Tyrosine recombinase XerD K04763 - - 0.0000000000000000000000000000000000000000000000000000000000002376 229.0
TLS2_k127_3208704_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000001051 181.0
TLS2_k127_321157_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009601 307.0
TLS2_k127_321157_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000002769 253.0
TLS2_k127_321157_2 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.00000000000000000000000000000000006567 147.0
TLS2_k127_3217120_0 PFAM Type II secretion system protein E K02454,K02504,K02652 - - 1.338e-229 724.0
TLS2_k127_3217120_1 TIGRFAM para-aminobenzoate synthase, subunit I K01665,K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 469.0
TLS2_k127_3217120_10 PFAM cytochrome oxidase assembly K02259 - - 0.00000000000000000000000000000000000000000000000000839 193.0
TLS2_k127_3217120_11 PFAM glycosyl transferase family 9 K02841 - - 0.000000000000000000000000000000000000000000002053 184.0
TLS2_k127_3217120_12 GHMP kinases C terminal K07031 - 2.7.1.168 0.000000000000000000000000000000000000000001045 173.0
TLS2_k127_3217120_13 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000001167 166.0
TLS2_k127_3217120_14 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000001227 169.0
TLS2_k127_3217120_15 - - - - 0.0000000000000001317 85.0
TLS2_k127_3217120_16 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000001147 67.0
TLS2_k127_3217120_18 Periplasmic protein thiol disulfide oxidoreductase, DsbE subfamily - - - 0.0000009088 59.0
TLS2_k127_3217120_19 AntiSigma factor - - - 0.0001415 48.0
TLS2_k127_3217120_2 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003424 407.0
TLS2_k127_3217120_3 thiosulfate sulfurtransferase activity K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004389 394.0
TLS2_k127_3217120_4 PFAM Peptidase M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001117 281.0
TLS2_k127_3217120_5 arylsulfatase activity K01133 - 3.1.6.6 0.00000000000000000000000000000000000000000000000000000000000000000000001558 271.0
TLS2_k127_3217120_6 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000004917 224.0
TLS2_k127_3217120_7 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000001359 220.0
TLS2_k127_3217120_8 HIT domain K02503 - - 0.000000000000000000000000000000000000000000000000000001099 199.0
TLS2_k127_3217120_9 RNA polymerase sigma factor K03088 GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000001114 195.0
TLS2_k127_3252383_0 Mn2 and Fe2 transporters of the NRAMP family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007513 387.0
TLS2_k127_3252383_1 Diguanylate cyclase with PAS PAC and GAF sensors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 318.0
TLS2_k127_3252383_2 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit K00162,K11381,K21417 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000004899 196.0
TLS2_k127_3252383_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000001942 134.0
TLS2_k127_3252383_4 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000007088 91.0
TLS2_k127_3254552_0 Domain of unknown function (DUF4331) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 554.0
TLS2_k127_3254552_1 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000004352 145.0
TLS2_k127_3254552_2 Anti-sigma-K factor rskA - - - 0.0000000000000000004469 101.0
TLS2_k127_3254552_3 Domain of unknown function (DUF4198) - - - 0.000000000005613 78.0
TLS2_k127_3256593_0 Involved in the tonB-independent uptake of proteins K01256,K03641 - 3.4.11.2 0.00000000000000001233 87.0
TLS2_k127_3256593_1 Lysylphosphatidylglycerol synthase TM region - - - 0.0008646 51.0
TLS2_k127_3262484_0 peptidase S9 prolyl oligopeptidase active site - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007104 441.0
TLS2_k127_3262484_1 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000001185 164.0
TLS2_k127_3262484_2 DinB superfamily - - - 0.0000000000000000000000000000000656 132.0
TLS2_k127_3266395_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005447 423.0
TLS2_k127_3266395_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000003512 94.0
TLS2_k127_3266395_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000008105 75.0
TLS2_k127_3284798_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 599.0
TLS2_k127_3284798_1 Trypsin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 351.0
TLS2_k127_3284798_2 PFAM glycosyl transferase group 1 K13057 - 2.4.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000005245 268.0
TLS2_k127_3284798_3 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000066 160.0
TLS2_k127_3284798_4 IMP dehydrogenase activity K04767 - - 0.000000000000000000000103 105.0
TLS2_k127_3284798_5 Transcriptional Regulator, XRE family - - - 0.00005265 51.0
TLS2_k127_3284874_0 Belongs to the UDP-N-acetylglucosamine 2-epimerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005473 497.0
TLS2_k127_3284874_1 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 471.0
TLS2_k127_3284874_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 383.0
TLS2_k127_3284874_3 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006322 303.0
TLS2_k127_3284874_4 NAD(P)H-binding K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000001594 239.0
TLS2_k127_3284874_5 PFAM Glycosyl transferase family 4 K13007 - - 0.00000000000000000000000000000000000000000009245 181.0
TLS2_k127_3284874_6 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000002495 139.0
TLS2_k127_3286038_0 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 445.0
TLS2_k127_3286038_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009537 398.0
TLS2_k127_3288368_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 597.0
TLS2_k127_329308_0 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 424.0
TLS2_k127_329308_1 pfam abc K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004886 255.0
TLS2_k127_329308_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001845 261.0
TLS2_k127_329308_3 - - - - 0.0000000000000000000000000000002634 136.0
TLS2_k127_329308_4 CAAX protease self-immunity - - - 0.00000000000000006067 93.0
TLS2_k127_329354_0 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000007864 234.0
TLS2_k127_329354_1 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.000000000000000000000000000000000000000005563 170.0
TLS2_k127_329354_2 COG0517 FOG CBS domain - - - 0.00000000000000001494 89.0
TLS2_k127_3298426_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1185.0
TLS2_k127_3298426_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 532.0
TLS2_k127_3298426_10 Domain of unknown function (DUF3520) K07114 - - 0.0000000000000000000000002332 110.0
TLS2_k127_3298426_11 PFAM RNP-1 like RNA-binding protein - - - 0.000000000000000000000001509 107.0
TLS2_k127_3298426_12 von Willebrand factor, type A - - - 0.0000000000000000000004738 113.0
TLS2_k127_3298426_13 Putative bacterial sensory transduction regulator - - - 0.000000000001735 81.0
TLS2_k127_3298426_14 Domain of unknown function (DUF4390) - - - 0.00009276 54.0
TLS2_k127_3298426_15 COG0457 FOG TPR repeat - - - 0.0001822 55.0
TLS2_k127_3298426_2 translation release factor activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 393.0
TLS2_k127_3298426_3 His Kinase A (phosphoacceptor) domain K13598 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 396.0
TLS2_k127_3298426_4 two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001613 292.0
TLS2_k127_3298426_5 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000143 302.0
TLS2_k127_3298426_6 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000001662 228.0
TLS2_k127_3298426_7 long-chain fatty acid transporting porin activity K06076 - - 0.000000000000000000000000000000000000000000000000000000002428 216.0
TLS2_k127_3298426_8 lipase activity K15349 - - 0.000000000000000000000000000000000000000000000000000002127 209.0
TLS2_k127_3298426_9 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000000000003925 183.0
TLS2_k127_3321239_0 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 349.0
TLS2_k127_3321239_1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.00000000000000000000000000000000000000000000001328 173.0
TLS2_k127_3321239_2 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000002239 166.0
TLS2_k127_3327566_0 COGs COG0025 NhaP-type Na H and K H antiporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002825 311.0
TLS2_k127_3327566_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000002331 228.0
TLS2_k127_3327566_2 aminopeptidase N - - - 0.00000000000002518 88.0
TLS2_k127_334328_0 metallocarboxypeptidase activity K14054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008292 461.0
TLS2_k127_334328_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006852 345.0
TLS2_k127_334328_2 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000003121 253.0
TLS2_k127_334328_3 - - - - 0.0000000000000000000000000000000000000000000000001774 186.0
TLS2_k127_334328_4 Cell wall-associated hydrolase (invasion-associated protein) K21471 - - 0.00004911 54.0
TLS2_k127_3344783_0 Oxidoreductase NAD-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005128 313.0
TLS2_k127_3344783_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006199 310.0
TLS2_k127_3344783_2 NADH ubiquinone oxidoreductase 20 kDa subunit K14128 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000002423 222.0
TLS2_k127_3344783_3 Histidine kinase - - - 0.000000000009522 69.0
TLS2_k127_3376930_0 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001704 291.0
TLS2_k127_3376930_1 Uncharacterized protein conserved in bacteria (DUF2255) - - - 0.00000000001132 78.0
TLS2_k127_3376930_2 MacB-like periplasmic core domain - - - 0.000000001141 67.0
TLS2_k127_3379246_0 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000008782 186.0
TLS2_k127_3379246_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000009884 83.0
TLS2_k127_3379246_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000001766 57.0
TLS2_k127_3383421_0 Acyl-CoA dehydrogenase, N-terminal domain - - - 6.531e-264 829.0
TLS2_k127_3383421_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 497.0
TLS2_k127_3383421_2 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.000000000000000000000000000000000000000000000000000006532 197.0
TLS2_k127_3383421_3 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000008015 170.0
TLS2_k127_3383421_4 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000005201 95.0
TLS2_k127_3383421_5 Dolichyl-phosphate-mannose-protein mannosyltransferase K14340 - - 0.0000000003926 73.0
TLS2_k127_3383421_6 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000009869 57.0
TLS2_k127_3396735_0 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 456.0
TLS2_k127_3396735_1 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 431.0
TLS2_k127_3396735_2 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 361.0
TLS2_k127_3396735_3 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 337.0
TLS2_k127_3396735_4 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 291.0
TLS2_k127_3396735_5 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000001156 270.0
TLS2_k127_3396735_6 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000001199 68.0
TLS2_k127_3421099_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000005905 244.0
TLS2_k127_3421099_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.0000002347 63.0
TLS2_k127_3422043_0 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000077 349.0
TLS2_k127_3422043_1 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000001127 217.0
TLS2_k127_3441515_0 Fumarate reductase flavoprotein C-term K00239,K00244,K00278 GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0022900,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803 1.3.5.1,1.3.5.4,1.4.3.16 2.079e-267 838.0
TLS2_k127_3441515_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240,K00245 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005929 351.0
TLS2_k127_3441515_2 LysM domain - - - 0.000000000000000000000000000000000000000000000000001382 193.0
TLS2_k127_3441515_3 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane K00246 - - 0.00000000000000002199 94.0
TLS2_k127_3444453_0 Histidine ammonia-lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000001282 174.0
TLS2_k127_3444453_1 - - - - 0.000000000000000001073 90.0
TLS2_k127_3444453_2 - - - - 0.000000001835 61.0
TLS2_k127_3461724_0 IgA Peptidase M64 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009578 339.0
TLS2_k127_3461724_1 COG0655 Multimeric flavodoxin WrbA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001506 292.0
TLS2_k127_3473552_0 ABC transporter K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008509 359.0
TLS2_k127_3473552_1 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 303.0
TLS2_k127_3473552_2 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.00000000000000000000000000000000000000000000000000000000000005144 232.0
TLS2_k127_3473552_3 Pfam:TPM K08988 - - 0.000000000000000000000001568 109.0
TLS2_k127_3473552_4 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000007744 58.0
TLS2_k127_3473760_0 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000001767 145.0
TLS2_k127_3498550_0 glutamate carboxypeptidase K01301 - 3.4.17.21 7.035e-255 802.0
TLS2_k127_3498550_1 Aldehyde dehydrogenase family - - - 0.000000000000000000000000002678 111.0
TLS2_k127_3509029_0 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009752 309.0
TLS2_k127_3509029_1 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000000000000000000000000008081 134.0
TLS2_k127_3509029_3 helicase superfamily c-terminal domain - - - 0.0000000504 63.0
TLS2_k127_3509029_4 Redoxin - - - 0.0006089 44.0
TLS2_k127_3509747_0 Ftsk_gamma K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 552.0
TLS2_k127_3509747_1 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000001163 274.0
TLS2_k127_3509747_2 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000006814 257.0
TLS2_k127_3509747_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000003859 153.0
TLS2_k127_3509747_4 transferase activity, transferring glycosyl groups K20742 - 3.4.14.13 0.000000000000000000000000000000003556 133.0
TLS2_k127_3509747_5 PFAM MbtH domain protein K05375 - - 0.0000000000000000000000000001935 118.0
TLS2_k127_3509747_6 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000001457 102.0
TLS2_k127_3509747_7 Autotransporter beta-domain - - - 0.000001573 61.0
TLS2_k127_351729_0 iron ion homeostasis K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 433.0
TLS2_k127_351729_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000007298 119.0
TLS2_k127_351729_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000009001 88.0
TLS2_k127_3521923_0 TIGRFAM amino acid adenylation domain - - - 2.154e-204 669.0
TLS2_k127_3521923_1 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 534.0
TLS2_k127_3521923_2 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003275 427.0
TLS2_k127_352566_0 PFAM Peptidase M16 inactive domain K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000003434 248.0
TLS2_k127_352566_1 PFAM Peptidase M16 inactive domain - - - 0.0000000002645 74.0
TLS2_k127_353771_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006239 568.0
TLS2_k127_353771_1 YmdB-like protein K09769 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001075 301.0
TLS2_k127_353771_2 Protein of unknown function (DUF3179) - - - 0.0000000000000000000000000000000000000000001661 167.0
TLS2_k127_353771_3 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000000000000000000000000000000000000006426 152.0
TLS2_k127_353771_4 - - - - 0.00000000000000007276 93.0
TLS2_k127_353771_5 PFAM metallophosphoesterase K07098 - - 0.000000000000001916 90.0
TLS2_k127_353771_6 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.00000002109 67.0
TLS2_k127_353771_7 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000002848 56.0
TLS2_k127_3547361_0 Cysteine-rich secretory protein family - - - 0.00000000001959 77.0
TLS2_k127_3547361_1 Pfam:Methyltransf_26 - - - 0.0002654 48.0
TLS2_k127_3547377_0 Belongs to the peptidase S1 family K01310,K01312 - 3.4.21.1,3.4.21.4 0.0000000831 65.0
TLS2_k127_3547377_1 aminopeptidase K05994 - 3.4.11.10 0.00006619 55.0
TLS2_k127_3547377_2 Pfam:Methyltransf_26 - - - 0.0003809 48.0
TLS2_k127_360189_0 phosphate ion binding K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 426.0
TLS2_k127_360189_1 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 302.0
TLS2_k127_360189_2 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000022 292.0
TLS2_k127_362010_0 Lanthionine synthetase C family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002086 280.0
TLS2_k127_362010_1 Cupin domain - - - 0.000000000000000000000000001021 130.0
TLS2_k127_362010_2 Insulinase (Peptidase family M16) - - - 0.00006489 55.0
TLS2_k127_3659050_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 452.0
TLS2_k127_3659050_1 DNA polymerase beta thumb K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 442.0
TLS2_k127_366162_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000003155 251.0
TLS2_k127_366162_1 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.0000000000000000000000000000003966 128.0
TLS2_k127_366162_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000001434 87.0
TLS2_k127_3666747_0 denitrification pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 297.0
TLS2_k127_3666747_1 amine dehydrogenase activity - - - 0.00000007823 66.0
TLS2_k127_3669779_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 385.0
TLS2_k127_3684429_0 Type IV leader peptidase family K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000001265 216.0
TLS2_k127_3684429_1 Peptidase family M28 - - - 0.0000000000000000000000000000198 127.0
TLS2_k127_3684429_2 Type II secretion system (T2SS), protein G K02456 - - 0.00000004235 62.0
TLS2_k127_3685057_0 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004436 593.0
TLS2_k127_3685057_1 Transglycosylase SLT domain K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006588 406.0
TLS2_k127_369204_0 Arylsulfotransferase (ASST) - - - 0.00000000000000000000000000000000000000000002633 175.0
TLS2_k127_3718238_0 Phage tail sheath C-terminal domain K06907 - - 2.365e-212 681.0
TLS2_k127_3718238_1 Domain of Unknown Function (DUF748) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004398 419.0
TLS2_k127_3718238_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 357.0
TLS2_k127_3718238_3 T4-like virus tail tube protein gp19 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 299.0
TLS2_k127_3718238_4 aminopeptidase - - - 0.00000000000000000000000000000000000000000000000009443 203.0
TLS2_k127_3718238_5 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000442 156.0
TLS2_k127_3718238_6 - - - - 0.0000000000004755 76.0
TLS2_k127_3731147_0 glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007267 387.0
TLS2_k127_3731147_1 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002322 254.0
TLS2_k127_3731147_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002676 252.0
TLS2_k127_3731147_3 PFAM LmbE family protein - - - 0.00000000000000000000000000000000000000000000000000000000001441 216.0
TLS2_k127_3731147_4 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000007181 211.0
TLS2_k127_3731147_5 PFAM glycosyl transferase family 39 - - - 0.0000000000000000000000000000000214 147.0
TLS2_k127_3731147_6 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000001334 106.0
TLS2_k127_3731147_7 Dehydrogenase - - - 0.00000000000003626 87.0
TLS2_k127_3753560_0 Rod shape-determining protein K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 539.0
TLS2_k127_3753560_1 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007224 571.0
TLS2_k127_3753560_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003694 439.0
TLS2_k127_3753560_3 PFAM Cys Met metabolism K01739,K01761 - 2.5.1.48,4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003279 287.0
TLS2_k127_3753560_4 peptidyl-prolyl isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000007498 222.0
TLS2_k127_3753560_5 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000542 174.0
TLS2_k127_3753560_6 FecR protein - - - 0.0004167 53.0
TLS2_k127_3761570_0 PFAM peptidase M14 carboxypeptidase A - - - 0.000000000000000000000000000000000000000000000001076 188.0
TLS2_k127_3761570_1 C-5 cytosine-specific DNA methylase K00558 - 2.1.1.37 0.00000000000000000000000000000000000000004675 156.0
TLS2_k127_3775740_0 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008992 347.0
TLS2_k127_3775740_1 LemA family K03744 - - 0.0000000000000000000000000000000000000000000969 163.0
TLS2_k127_3775740_2 Bacterial PH domain K08981 - - 0.000000000000000000000000000000001437 132.0
TLS2_k127_3775740_3 membrane-fusion protein - - - 0.0000000000000000000000000000003491 141.0
TLS2_k127_3775740_4 membrane-fusion protein - - - 0.0000000000000000000000000001804 134.0
TLS2_k127_3775740_5 HlyD family secretion protein - - - 0.000000000000000000004266 107.0
TLS2_k127_3778107_0 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001655 290.0
TLS2_k127_3778107_1 Protein of unknown function (DUF1684) K09164 - - 0.0000000000000000000000000000000000000000000000000000000000000005933 224.0
TLS2_k127_3783174_0 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 509.0
TLS2_k127_3783174_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005469 354.0
TLS2_k127_3783174_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.000000000000000000000000000000401 124.0
TLS2_k127_3783174_3 Protein of unknown function (DUF1328) - - - 0.000000003351 60.0
TLS2_k127_3783919_0 Erythromycin esterase - - - 0.0000000000000000000000000000000000000000000000000287 190.0
TLS2_k127_3783919_1 TIGRFAM metal dependent phophohydrolase - - - 0.00000000000000000000000000006097 118.0
TLS2_k127_3783919_2 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000003443 79.0
TLS2_k127_3784002_0 PFAM NAD-dependent epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009184 475.0
TLS2_k127_3784002_1 alpha beta - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 371.0
TLS2_k127_3784002_10 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family K03406 - - 0.000000001434 72.0
TLS2_k127_3784002_11 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000393 58.0
TLS2_k127_3784002_2 HD domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001346 274.0
TLS2_k127_3784002_3 tRNA 3'-trailer cleavage - - - 0.000000000000000000000000000000000000000000000000000000000000005485 236.0
TLS2_k127_3784002_4 Glycosyl transferase family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000003211 222.0
TLS2_k127_3784002_5 Nucleotidyl transferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000002146 216.0
TLS2_k127_3784002_6 arylsulfatase A - - - 0.000000000000000000000000000000000000000000000000000002024 219.0
TLS2_k127_3784002_7 O-Antigen ligase K18814 - - 0.00000000000000000000000000005081 131.0
TLS2_k127_3784002_8 TIGRFAM Serine O-acetyltransferase K00640 - 2.3.1.30 0.0000000000000000000000003033 121.0
TLS2_k127_3784002_9 PIN domain - - - 0.000000000003041 78.0
TLS2_k127_3796916_0 Beta-lactamase class C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002921 360.0
TLS2_k127_3796916_1 phosphoprotein phosphatase activity K01525 GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564 3.6.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000003728 246.0
TLS2_k127_3796916_2 Acetyl-coenzyme A transporter 1 K08218 - - 0.000000000000000000000000000000006925 138.0
TLS2_k127_3803392_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 607.0
TLS2_k127_3803392_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 540.0
TLS2_k127_3803392_2 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 447.0
TLS2_k127_3803392_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005005 428.0
TLS2_k127_3803392_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005346 288.0
TLS2_k127_3803392_5 hyperosmotic response - - - 0.00000000000000000000000002155 121.0
TLS2_k127_3803392_6 GTPase activity K03596,K04771,K21594 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0019904,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043022,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046872,GO:0061745,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 3.4.21.107 0.0000000000608 67.0
TLS2_k127_3807594_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005057 346.0
TLS2_k127_3807594_1 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.000000000000000000000000000000000003461 139.0
TLS2_k127_3807594_2 Ribosomal prokaryotic L21 protein K02888 - - 0.000000000000000000000001437 111.0
TLS2_k127_3813081_0 Acetyl-CoA hydrolase/transferase C-terminal domain - - - 1.121e-200 642.0
TLS2_k127_3819235_0 Predicted permease K07089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004126 509.0
TLS2_k127_3819235_1 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 467.0
TLS2_k127_3819235_2 SMART regulatory protein ArsR - - - 0.0000000000000000000004576 104.0
TLS2_k127_3819235_3 Thioredoxin domain - - - 0.000000000000000000006109 94.0
TLS2_k127_3819267_0 PFAM AMP-dependent synthetase and ligase K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000852 438.0
TLS2_k127_3819267_1 Sodium:solute symporter family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 414.0
TLS2_k127_3819267_2 Alpha beta hydrolase K01055,K14727 - 3.1.1.24,4.1.1.44 0.000000000000000000001089 111.0
TLS2_k127_382074_0 NeuB family K01654 - 2.5.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000003289 271.0
TLS2_k127_382074_1 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000001885 211.0
TLS2_k127_382074_2 Vibrio cholerae RfbT protein - - - 0.00000000000000000000005116 115.0
TLS2_k127_382074_3 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.00006439 55.0
TLS2_k127_3824346_0 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005721 493.0
TLS2_k127_3824346_1 prohibitin homologues K07192 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004923 276.0
TLS2_k127_3824346_10 Endoribonuclease L-PSP - - - 0.000000000000000002171 89.0
TLS2_k127_3824346_11 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00000000001888 74.0
TLS2_k127_3824346_12 Trypsin-like serine protease - - - 0.0007327 51.0
TLS2_k127_3824346_2 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000007256 251.0
TLS2_k127_3824346_3 PFAM CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000001076 235.0
TLS2_k127_3824346_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000001607 216.0
TLS2_k127_3824346_5 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000004053 164.0
TLS2_k127_3824346_6 SPTR CopG domain protein DNA-binding domain protein - - - 0.00000000000000000000000000000104 124.0
TLS2_k127_3824346_7 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000000000000000008436 106.0
TLS2_k127_3824346_8 Peptidase M48 - - - 0.00000000000000000000001535 117.0
TLS2_k127_3824346_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000001554 97.0
TLS2_k127_3826392_0 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000003883 232.0
TLS2_k127_3826392_1 Belongs to the bacterial histone-like protein family K03530 - - 0.00000000000000000000000000003328 118.0
TLS2_k127_3826392_2 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000001149 78.0
TLS2_k127_3826392_3 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.000000003047 70.0
TLS2_k127_3832775_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000007586 203.0
TLS2_k127_3832775_1 Sulfatase - - - 0.0000000000000000000000000000000000000009796 162.0
TLS2_k127_3832775_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000003903 71.0
TLS2_k127_3832775_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000001814 68.0
TLS2_k127_3832775_4 Membrane - - - 0.00018 54.0
TLS2_k127_3833247_0 phosphate transport system permease protein K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 567.0
TLS2_k127_3833247_1 Binding-protein-dependent transport system inner membrane component K02037,K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 529.0
TLS2_k127_3833247_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000001375 138.0
TLS2_k127_3842724_0 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000271 280.0
TLS2_k127_3842724_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000001789 139.0
TLS2_k127_3842724_2 Polymer-forming cytoskeletal - - - 0.000000000000000000001718 101.0
TLS2_k127_3851109_0 Methyl-transferase K18912 - 1.14.99.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008196 516.0
TLS2_k127_3851109_1 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00758 - 2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 327.0
TLS2_k127_3851109_10 MerR HTH family regulatory protein - - - 0.0006116 51.0
TLS2_k127_3851109_2 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002044 284.0
TLS2_k127_3851109_3 Phosphorylase superfamily K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002322 273.0
TLS2_k127_3851109_4 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002562 296.0
TLS2_k127_3851109_5 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000007269 261.0
TLS2_k127_3851109_6 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000003826 233.0
TLS2_k127_3851109_7 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000002017 211.0
TLS2_k127_3851109_8 Acylphosphatase K01512 - 3.6.1.7 0.0000000000000006631 91.0
TLS2_k127_3851109_9 peptidyl-tyrosine sulfation - - - 0.00003266 51.0
TLS2_k127_3862667_0 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004023 380.0
TLS2_k127_3862667_1 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.00000000000000000000000000000000000000000000005866 188.0
TLS2_k127_3862667_2 ATP-independent chaperone mediated protein folding - - - 0.000000000000000000000002157 119.0
TLS2_k127_3862897_0 PIN domain K07175 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 589.0
TLS2_k127_3862897_1 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 327.0
TLS2_k127_3862897_2 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 323.0
TLS2_k127_3869190_0 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 501.0
TLS2_k127_3869190_1 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 441.0
TLS2_k127_3869190_2 Toxin-antitoxin system, toxin component, PIN family - - - 0.00000000000000000000000000002926 121.0
TLS2_k127_3869190_3 PFAM HicB family - - - 0.0000001527 60.0
TLS2_k127_3871215_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.143e-245 782.0
TLS2_k127_3871215_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 6.592e-201 655.0
TLS2_k127_3871215_2 DHH family K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000004943 222.0
TLS2_k127_3871215_3 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000001656 216.0
TLS2_k127_3871215_4 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.00000000000000000000000000000000000000000000000000003538 210.0
TLS2_k127_3871215_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000001216 128.0
TLS2_k127_3871215_6 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000000000005426 106.0
TLS2_k127_3871215_7 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000002261 106.0
TLS2_k127_3871215_8 PFAM YcfA-like - - - 0.000000000000000007267 89.0
TLS2_k127_3871215_9 Protein of unknown function (DUF503) K09764 - - 0.00000000001805 73.0
TLS2_k127_3881409_0 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 - 4.1.3.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 375.0
TLS2_k127_3881409_1 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005661 292.0
TLS2_k127_3881409_2 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily K01911 - 6.2.1.26 0.00000000000000000000001957 115.0
TLS2_k127_3884865_0 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 392.0
TLS2_k127_3884865_1 protein conserved in bacteria K09798 - - 0.000000000000000000000000000000000000000005146 167.0
TLS2_k127_3884865_2 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000000000000000000000000000000000004254 143.0
TLS2_k127_3884865_3 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.00000000000000000000000000002368 123.0
TLS2_k127_3884865_4 Peptidase family M23 K21471 - - 0.000000000000000000000003143 115.0
TLS2_k127_3884865_5 Peptidase, S41 K03797 - 3.4.21.102 0.00000000000000000002279 104.0
TLS2_k127_3884865_6 CAAX protease self-immunity K07052 - - 0.0000000001862 72.0
TLS2_k127_3884954_0 Amino acid adenylation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 505.0
TLS2_k127_3894697_0 Aconitase C-terminal domain K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000001004 228.0
TLS2_k127_3894697_1 PAS domain - - - 0.000000000000000000000000000000000000000000000001067 178.0
TLS2_k127_3894697_2 oxidoreductase activity - - - 0.0000000000000000003169 102.0
TLS2_k127_3896409_0 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 0.00000000000000000000000000408 125.0
TLS2_k127_3896409_1 Alpha/beta hydrolase family - - - 0.00000000000000000000006617 104.0
TLS2_k127_3896409_2 - - - - 0.000000000001163 69.0
TLS2_k127_3896409_3 Patatin-like phospholipase K07001 - - 0.0001261 57.0
TLS2_k127_3912368_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 603.0
TLS2_k127_3912368_1 Domain of unknown function (DUF4347) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 600.0
TLS2_k127_3912368_2 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 561.0
TLS2_k127_3912368_3 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000752 418.0
TLS2_k127_3912368_5 Glycosyl transferase family group 2 - - - 0.000000000000000002096 97.0
TLS2_k127_3912368_6 PFAM Glycosyl transferase family 2 - - - 0.0000000000000807 82.0
TLS2_k127_3915421_0 PFAM ATP-binding region ATPase domain protein K07709 - 2.7.13.3 0.000000000000000000000000000000006105 138.0
TLS2_k127_3915421_1 Type II transport protein GspH K08084 - - 0.000000439 60.0
TLS2_k127_3930201_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000006017 101.0
TLS2_k127_3930201_1 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000001205 67.0
TLS2_k127_3943183_0 Two component signalling adaptor domain K02487,K06596 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009218 432.0
TLS2_k127_396163_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 616.0
TLS2_k127_396163_1 Fe-S cluster K03616 - - 0.00000000000000000001121 98.0
TLS2_k127_3965422_0 Enoyl-CoA hydratase/isomerase K07539 - 3.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 381.0
TLS2_k127_3965422_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07538 - 1.1.1.368 0.000000000000000000000000000000000000000000000000000000000000001788 225.0
TLS2_k127_3972383_0 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 308.0
TLS2_k127_3972383_1 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 302.0
TLS2_k127_3972383_2 Peptidase M16 inactive domain K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001534 261.0
TLS2_k127_3972383_3 4Fe-4S dicluster domain K00124 - - 0.0000000000000000000000000000000000000000000000000000000006451 204.0
TLS2_k127_3972383_4 Domain of unknown function (DUF892) - - - 0.000000000000000000000000000000000000000004725 166.0
TLS2_k127_3972383_5 DNA-templated transcription, termination K03628 - - 0.0000000000000000000000000003637 117.0
TLS2_k127_3979056_0 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 584.0
TLS2_k127_3979056_1 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 583.0
TLS2_k127_3979056_2 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 546.0
TLS2_k127_3979056_3 LemA family K03744 - - 0.0000000000000000000000000004008 123.0
TLS2_k127_3979800_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.01e-240 770.0
TLS2_k127_3979800_1 GTP binding K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008607 269.0
TLS2_k127_3979800_2 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005276 260.0
TLS2_k127_3979800_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000203 88.0
TLS2_k127_3979800_4 Domain of unknown function (DUF2520) - - - 0.0000000000002096 81.0
TLS2_k127_3979800_5 Hsp20/alpha crystallin family - - - 0.000000004088 63.0
TLS2_k127_3990924_0 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007347 351.0
TLS2_k127_3990924_1 PFAM CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001493 260.0
TLS2_k127_3990924_2 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000005252 61.0
TLS2_k127_4000131_0 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 601.0
TLS2_k127_4000131_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002597 310.0
TLS2_k127_4000131_2 asparaginase activity K01424 - 3.5.1.1 0.000000000000000000000000000000000000000003391 160.0
TLS2_k127_4000131_3 exporters of the RND superfamily K07003 - - 0.00000000000000000000000000000000000003869 155.0
TLS2_k127_4000131_4 Cadherin-like - - - 0.000000000000000001825 99.0
TLS2_k127_4009631_0 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 558.0
TLS2_k127_4009631_1 Rubrerythrin K22405 - 1.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 486.0
TLS2_k127_4009631_2 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000009784 209.0
TLS2_k127_4009631_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000003764 168.0
TLS2_k127_4009631_4 Cytochrome c - - - 0.000000000000000000000000000000000000000001587 175.0
TLS2_k127_4009631_5 Cytochrome c - - - 0.000000000000000001612 100.0
TLS2_k127_4009631_6 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000006194 77.0
TLS2_k127_4009631_7 PFAM GCN5-related N-acetyltransferase - - - 0.0001441 53.0
TLS2_k127_4022707_0 GTP-binding protein TypA K06207 - - 1.079e-244 774.0
TLS2_k127_4022707_1 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity K00819,K00821 GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 576.0
TLS2_k127_4022707_2 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 487.0
TLS2_k127_4022707_3 signal peptide processing K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000478 214.0
TLS2_k127_4022707_4 OsmC-like protein K04063 - - 0.00000000000000000000000000000000000000000000000001551 183.0
TLS2_k127_4022707_5 Belongs to the ompA family K03286 - - 0.000000000000000000000000000000000000000000000142 180.0
TLS2_k127_4022707_6 Peptidase family M23 K21472 - - 0.000000000000000000000000000000000000000000002485 173.0
TLS2_k127_4022707_7 Protein of Unknown function (DUF2784) - - - 0.0000000000000000000000000000000000000000007856 166.0
TLS2_k127_4022707_8 Copper binding periplasmic protein CusF - - - 0.0000000000000001218 87.0
TLS2_k127_4022707_9 Domain of unknown function (DUF4412) - - - 0.0001728 53.0
TLS2_k127_4024296_0 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000001686 280.0
TLS2_k127_4024296_1 peroxidase activity K09162 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 0.000000000000000000000003595 103.0
TLS2_k127_4024296_2 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.000000000000000002917 87.0
TLS2_k127_4039513_0 Radical SAM superfamily K06871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000599 547.0
TLS2_k127_4039513_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 511.0
TLS2_k127_4039513_2 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 443.0
TLS2_k127_4039513_3 Asparaginase K01444 - 3.5.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000562 344.0
TLS2_k127_4039513_4 PFAM Prenyltransferase squalene oxidase K06045,K17811 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009267,GO:0009605,GO:0009607,GO:0009975,GO:0009987,GO:0009991,GO:0010350,GO:0016101,GO:0016102,GO:0016114,GO:0016853,GO:0016872,GO:0019637,GO:0031667,GO:0031668,GO:0031669,GO:0033385,GO:0033554,GO:0035439,GO:0035440,GO:0042594,GO:0043167,GO:0043169,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071496,GO:0071704,GO:0075136,GO:1901576 4.2.1.129,5.4.99.17,5.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009302 316.0
TLS2_k127_4039513_5 transcription factor binding K15836 - - 0.00000000000000000000000000000000000000000000000000000000000000000001488 252.0
TLS2_k127_4039513_6 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.000000000000000000000000000000000000000000000000000000001043 220.0
TLS2_k127_4039513_7 metallopeptidase activity - - - 0.0002143 55.0
TLS2_k127_4046363_0 TolB amino-terminal domain K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.00000000000000000000000000000000000000000000000000000000000000000000000008025 265.0
TLS2_k127_4046363_1 lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000469 184.0
TLS2_k127_4046363_2 MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000000000001523 188.0
TLS2_k127_4046363_3 PFAM OmpA MotB domain protein K03640 - - 0.0000000000000000000000000000000000007625 147.0
TLS2_k127_4046363_4 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000000000000000001582 123.0
TLS2_k127_4046363_5 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000002075 119.0
TLS2_k127_4046363_6 TonB C terminal K03646,K03832 - - 0.00000000001476 76.0
TLS2_k127_4046363_7 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.000000002589 62.0
TLS2_k127_4051180_0 Elongation factor P--(R)-beta-lysine ligase K04568 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016746,GO:0016755,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052868,GO:0071704,GO:0071915,GO:0072580,GO:0072581,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001437 255.0
TLS2_k127_4051180_1 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000007072 132.0
TLS2_k127_4051180_2 Belongs to the glycosyl hydrolase family 6 - - - 0.000000000000000001219 99.0
TLS2_k127_4083591_0 Protein export membrane protein K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004384 305.0
TLS2_k127_4090475_0 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002094 235.0
TLS2_k127_4090475_1 UPF0761 membrane protein K07058 - - 0.0000000000000000000000000000966 130.0
TLS2_k127_4090475_2 Bacterial protein of unknown function (DUF883) - - - 0.0006279 48.0
TLS2_k127_41092_0 Prolyl oligopeptidase family - - - 8.983e-212 669.0
TLS2_k127_41092_1 involved in cell wall biogenesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 336.0
TLS2_k127_4109210_0 ATP-dependent peptidase activity K01338 - 3.4.21.53 3.073e-197 625.0
TLS2_k127_4109210_1 PFAM peptidase M48 Ste24p - - - 0.000000000000000000000000000000000000000000000000000000127 206.0
TLS2_k127_411118_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001142 250.0
TLS2_k127_411118_1 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000000000000000000003374 165.0
TLS2_k127_411118_2 - - - - 0.00000000000000000000000000161 121.0
TLS2_k127_4119678_0 riboflavin synthase, alpha K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000006281 166.0
TLS2_k127_4128429_0 4 iron, 4 sulfur cluster binding K03737 - 1.2.7.1 0.0 1298.0
TLS2_k127_4128429_1 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006602 407.0
TLS2_k127_4128429_2 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000005743 265.0
TLS2_k127_4134564_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261,K00262 - 1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002859 270.0
TLS2_k127_4134564_1 converts alpha-aldose to the beta-anomer - - - 0.000000000000000000000000000000000000000000000000000001229 202.0
TLS2_k127_4136806_0 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000000000000000000000000000000000000002744 222.0
TLS2_k127_4139535_0 Beta-eliminating lyase K01667 - 4.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 502.0
TLS2_k127_4139535_1 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.0000000000000002625 91.0
TLS2_k127_4139535_2 Protein of unknown function (DUF3891) - - - 0.000000000005857 75.0
TLS2_k127_4139535_3 Glycosyl transferase, family 2 - - - 0.00000001708 61.0
TLS2_k127_4139535_4 PFAM PEGA domain - - - 0.0000008931 61.0
TLS2_k127_4146255_0 Bacterial sugar transferase K03606 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005372 353.0
TLS2_k127_4146255_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008266 309.0
TLS2_k127_4146255_2 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001836 253.0
TLS2_k127_4153517_0 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 359.0
TLS2_k127_4153517_1 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 341.0
TLS2_k127_4153517_2 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000001543 208.0
TLS2_k127_4153517_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.00000000000000000002347 92.0
TLS2_k127_4167802_0 glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 391.0
TLS2_k127_4167802_1 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000003777 115.0
TLS2_k127_4167802_2 Protein of unknown function (DUF2384) - - - 0.0000000000000000000003163 100.0
TLS2_k127_4167802_3 RES - - - 0.000000000000000006599 90.0
TLS2_k127_4167802_4 - - - - 0.00007583 54.0
TLS2_k127_4171268_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 328.0
TLS2_k127_4171268_1 NifU-like N terminal domain K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.0000000000000000000000000000000000000000000000193 186.0
TLS2_k127_4171268_2 metal-sulfur cluster biosynthetic enzyme K02612 - - 0.00000000000000000000000000000000004067 141.0
TLS2_k127_4171268_3 Protein of unknown function (DUF1684) K09164 - - 0.00000000000000000000006998 111.0
TLS2_k127_4171268_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000001907 63.0
TLS2_k127_4189502_0 OST-HTH/LOTUS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 367.0
TLS2_k127_4203681_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000007293 159.0
TLS2_k127_4203681_1 enoyl-[acyl-carrier-protein] reductase (NADH) activity K10780 - 1.3.1.104 0.0000000000000000000001907 101.0
TLS2_k127_4215014_0 Sortilin, neurotensin receptor 3, - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002886 349.0
TLS2_k127_4215014_1 NmrA-like family - - - 0.000000000000000002533 86.0
TLS2_k127_4242792_0 Sulfate ABC transporter, periplasmic sulfate-binding protein K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 460.0
TLS2_k127_4242792_1 ATPase activity K02045 - 3.6.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 396.0
TLS2_k127_4242792_2 Sulfate ABC transporter inner membrane subunit CysT K02046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 370.0
TLS2_k127_4242792_3 Binding-protein-dependent transport system inner membrane component K02047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009698 342.0
TLS2_k127_4255097_0 Glucose-1-phosphate cytidylyltransferase K00978 - 2.7.7.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004517 340.0
TLS2_k127_4255097_1 methyltransferase - - - 0.0000000000000000000000000000000006663 134.0
TLS2_k127_4255097_2 Glycosyl transferase, family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000003122 129.0
TLS2_k127_426023_0 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000004354 246.0
TLS2_k127_426023_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000009772 243.0
TLS2_k127_426023_2 Metallopeptidase family M24 K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000002044 186.0
TLS2_k127_426023_3 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000001381 134.0
TLS2_k127_426023_4 transcriptional regulator (AraC family) - - - 0.0000000000000000000005467 99.0
TLS2_k127_4268528_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006373 464.0
TLS2_k127_4268528_1 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000003899 209.0
TLS2_k127_4283842_0 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008219 424.0
TLS2_k127_4283842_1 RDD family - - - 0.0003889 48.0
TLS2_k127_4355098_0 helicase domain protein - - - 1.262e-204 674.0
TLS2_k127_4355098_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 435.0
TLS2_k127_4355098_2 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 327.0
TLS2_k127_4355098_3 copper resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 297.0
TLS2_k127_4355098_4 ABC-2 type transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005506 299.0
TLS2_k127_4355098_5 Histidine kinase K07778 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000005435 255.0
TLS2_k127_4355098_6 TIR domain - - - 0.000000000000000000000000000000000023 142.0
TLS2_k127_4355098_7 GGDEF domain - - - 0.000000000000000000000000000000001368 145.0
TLS2_k127_4355098_8 TIR domain - - - 0.00000000000000000000000000000001038 139.0
TLS2_k127_4358265_0 Domain of unknown function (DUF4915) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 322.0
TLS2_k127_4358265_1 domain protein K12287,K13735,K20276,K21449 - - 0.000000000000000000000000000000000000000000000000000000000000000000008138 263.0
TLS2_k127_435893_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005969 406.0
TLS2_k127_435893_1 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000004817 168.0
TLS2_k127_435893_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 0.00000000000274 68.0
TLS2_k127_435893_3 Belongs to the peptidase S51 family K13282 - 3.4.15.6 0.000001079 60.0
TLS2_k127_4369569_0 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003215 250.0
TLS2_k127_4369569_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000003393 188.0
TLS2_k127_4369569_2 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000006343 98.0
TLS2_k127_440478_0 Pfam:HxxPF_rpt - - - 0.0 1370.0
TLS2_k127_4508671_0 PFAM tRNA synthetases class I (E and Q), catalytic domain K01886 - 6.1.1.18 1.185e-240 764.0
TLS2_k127_4508671_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 452.0
TLS2_k127_4508671_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 337.0
TLS2_k127_4508671_3 SPTR Membrane or secreted protein - - - 0.0006424 50.0
TLS2_k127_4521350_0 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 457.0
TLS2_k127_4521350_1 Polymer-forming cytoskeletal - - - 0.00000000000000000002356 98.0
TLS2_k127_4532482_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005167 362.0
TLS2_k127_4532482_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000001678 281.0
TLS2_k127_4532482_2 response regulator K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001312 288.0
TLS2_k127_4532482_3 Calcineurin-like phosphoesterase K03269 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 0.0000000000000000000000000134 121.0
TLS2_k127_4532482_4 Domain present in phytochromes and cGMP-specific phosphodiesterases. K08968 - 1.8.4.14 0.00000000000000000000000006876 108.0
TLS2_k127_4557856_0 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 428.0
TLS2_k127_4557856_1 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000007509 216.0
TLS2_k127_457779_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000006426 261.0
TLS2_k127_457779_1 SpoIVB peptidase S55 - - - 0.000000000000000000000000000000000000000000000000000000009389 226.0
TLS2_k127_457779_2 Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.000000000000000000000000001014 121.0
TLS2_k127_457875_0 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 527.0
TLS2_k127_4601566_0 Cysteine desulfurase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 340.0
TLS2_k127_4601566_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000003529 109.0
TLS2_k127_4601566_2 Tetratricopeptide repeat K20543 - - 0.000000000000000007128 99.0
TLS2_k127_4601566_3 von willebrand factor, type A K07114 - - 0.000000001063 72.0
TLS2_k127_4603450_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000003722 180.0
TLS2_k127_4603450_1 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.00000000000000000000000000000000000000000000005735 175.0
TLS2_k127_4603450_2 Acyl-CoA reductase (LuxC) - - - 0.000000000000000000002789 106.0
TLS2_k127_4603450_3 DoxX - - - 0.00002731 56.0
TLS2_k127_4603450_4 Thioredoxin - - - 0.0001029 55.0
TLS2_k127_4606502_0 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K08295 - 6.2.1.32 0.000000000000000000000000000000000003095 140.0
TLS2_k127_4606502_1 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.00000000000000000000000000000007571 131.0
TLS2_k127_4632939_0 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 374.0
TLS2_k127_4632939_1 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001037 287.0
TLS2_k127_4678630_0 Part of a membrane complex involved in electron transport K03614 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008124 367.0
TLS2_k127_4678630_1 Part of a membrane complex involved in electron transport - - - 0.000000000000000000000000002539 128.0
TLS2_k127_4678630_2 Part of a membrane complex involved in electron transport K03615 - - 0.0000000001699 62.0
TLS2_k127_4681193_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474,K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006638 584.0
TLS2_k127_4681193_1 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 341.0
TLS2_k127_4681193_10 - - - - 0.000001267 53.0
TLS2_k127_4681193_11 PFAM Uncharacterised protein family UPF0150 - - - 0.0005067 45.0
TLS2_k127_4681193_2 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 353.0
TLS2_k127_4681193_3 Polysaccharide biosynthesis protein K01784,K02473 - 5.1.3.2,5.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 327.0
TLS2_k127_4681193_4 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000002506 244.0
TLS2_k127_4681193_5 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000003245 190.0
TLS2_k127_4681193_6 capsular polysaccharide biosynthesis protein K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000003559 169.0
TLS2_k127_4681193_7 guanyl-nucleotide exchange factor activity - - - 0.0000000000000000000000000000002055 141.0
TLS2_k127_4681193_8 polysaccharide export K01991 - - 0.0000000000000000000000002081 117.0
TLS2_k127_4681193_9 SMART PAS domain containing protein - - - 0.000000992 61.0
TLS2_k127_4693296_0 Non-ribosomal peptide synthetase modules and related - - - 1.835e-307 982.0
TLS2_k127_4695385_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1208.0
TLS2_k127_4695385_1 Short-chain alcohol dehydrogenase K16066 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.381 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007567 289.0
TLS2_k127_4695385_2 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.000000000000000000000000000000000000000000000000007121 185.0
TLS2_k127_4695385_3 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000007021 129.0
TLS2_k127_4695385_4 general secretion pathway protein K02456,K02650 - - 0.00000000000000008021 90.0
TLS2_k127_4695385_5 Cytochrome C oxidase, cbb3-type, subunit III K12263 - - 0.0001707 53.0
TLS2_k127_46983_0 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000001961 230.0
TLS2_k127_46983_1 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000002999 218.0
TLS2_k127_46983_2 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000006062 171.0
TLS2_k127_46983_3 Polysaccharide biosynthesis protein K03328,K16695 - - 0.00000000000000000000000000000366 131.0
TLS2_k127_4700035_0 Core-2/I-Branching enzyme - - - 0.000000000000000000000000000000000000000000000007241 193.0
TLS2_k127_4700035_1 - - - - 0.0000000000000003564 89.0
TLS2_k127_4700035_2 Transcriptional - - - 0.0000000006801 60.0
TLS2_k127_4702902_0 imidazolonepropionase activity K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003971 489.0
TLS2_k127_4702902_1 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 371.0
TLS2_k127_4702902_2 FMN-dependent dehydrogenase K01823 GO:0003674,GO:0003824,GO:0004452,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0071704,GO:1901576 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006249 325.0
TLS2_k127_4702902_3 imidazolonepropionase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 318.0
TLS2_k127_4702902_4 imidazolonepropionase activity K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000002889 259.0
TLS2_k127_4702902_5 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000007971 210.0
TLS2_k127_4702902_6 PFAM GHMP kinase K01597 - 4.1.1.33 0.0000000000000000000000000000000007097 149.0
TLS2_k127_4702902_7 GHMP kinases N terminal domain - - - 0.00000000000000000000002074 117.0
TLS2_k127_4704073_0 electron transport chain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004224 378.0
TLS2_k127_4704073_1 peroxiredoxin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006591 299.0
TLS2_k127_4704073_2 response regulator - - - 0.0000000000000000000000000001216 124.0
TLS2_k127_4704073_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000008198 114.0
TLS2_k127_4704073_4 cell adhesion - - - 0.0002327 51.0
TLS2_k127_4723437_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 3.872e-206 659.0
TLS2_k127_4723437_1 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001978 266.0
TLS2_k127_4723437_2 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.000000000000000191 86.0
TLS2_k127_4745377_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 368.0
TLS2_k127_4745377_1 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000001581 149.0
TLS2_k127_4745377_2 Could be involved in septation K06412 - - 0.000000000000000000000000000958 120.0
TLS2_k127_4757802_0 serine-type endopeptidase activity K20276 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006815 263.0
TLS2_k127_4757802_1 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000000000005651 166.0
TLS2_k127_4757802_2 efflux transmembrane transporter activity - - - 0.00000000000000000000000000003184 132.0
TLS2_k127_4765661_0 DNA polymerase A domain K02335 - 2.7.7.7 1.153e-209 682.0
TLS2_k127_4765661_1 Histidine kinase K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 632.0
TLS2_k127_4765661_2 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009881 334.0
TLS2_k127_4765661_3 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000001914 224.0
TLS2_k127_4765661_4 Transglycosylase associated protein - - - 0.00000000000000000000000002571 110.0
TLS2_k127_4770239_0 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 421.0
TLS2_k127_4770239_1 PIN domain K18828 - - 0.00000006263 54.0
TLS2_k127_4784701_0 Divalent cation transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008577 338.0
TLS2_k127_4784701_1 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002552 283.0
TLS2_k127_4784701_2 COGs COG1253 Hemolysins and related protein containing CBS domains - - - 0.0000000000000000000000000000000000000000000000000000004662 211.0
TLS2_k127_4784701_3 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0009645 43.0
TLS2_k127_4803213_0 PCRF K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000476 391.0
TLS2_k127_4803213_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000045 230.0
TLS2_k127_4803213_2 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000007169 181.0
TLS2_k127_4803213_3 Sporulation related domain - - - 0.000000001028 62.0
TLS2_k127_4803556_0 Enoyl-(Acyl carrier protein) reductase K13775 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 404.0
TLS2_k127_4803556_1 TfuA-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 391.0
TLS2_k127_4803556_2 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.000000000000000000000000000000000000000000000000000000000000000002015 243.0
TLS2_k127_4803556_3 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000003253 59.0
TLS2_k127_4824286_0 methyl-accepting chemotaxis protein K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 331.0
TLS2_k127_4824286_1 OmpA family - - - 0.00000000000000000000000000000006337 128.0
TLS2_k127_4827247_0 Belongs to the GARS family K01945,K01952,K13713 - 6.3.2.6,6.3.4.13,6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 452.0
TLS2_k127_4827247_1 phosphate acetyltransferase K00625,K13788 - 2.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000002897 267.0
TLS2_k127_4827247_2 PSP1 C-terminal domain protein - - - 0.000000000000000000000000000000000000000000000000000002767 199.0
TLS2_k127_4827247_3 Belongs to the PdxA family K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.0000000000000000000000000000000000000000000000001302 189.0
TLS2_k127_4827247_4 Hfq protein - - - 0.00000000000000000000000001121 121.0
TLS2_k127_4832700_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 1.088e-230 756.0
TLS2_k127_4832700_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000003016 205.0
TLS2_k127_4832700_2 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000007238 199.0
TLS2_k127_4832700_3 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000001067 153.0
TLS2_k127_4832700_5 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.0000000000000000000002499 102.0
TLS2_k127_4832700_6 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000008174 94.0
TLS2_k127_4832700_7 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000003612 54.0
TLS2_k127_4840928_0 DegT/DnrJ/EryC1/StrS aminotransferase family K00812,K22457 GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004177 337.0
TLS2_k127_4840928_1 - - - - 0.0000000000000004936 87.0
TLS2_k127_4856695_0 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008105 339.0
TLS2_k127_4856695_1 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009196 292.0
TLS2_k127_4856695_2 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.0000000000000000000000000000007483 142.0
TLS2_k127_4856695_3 Histidine kinase - - - 0.00000000028 65.0
TLS2_k127_4859814_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 616.0
TLS2_k127_4859814_1 peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 338.0
TLS2_k127_4859814_2 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002708 281.0
TLS2_k127_4859814_3 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008185 294.0
TLS2_k127_4859814_4 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004268 254.0
TLS2_k127_4859814_5 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000007306 184.0
TLS2_k127_4859814_6 Cytochrome c - - - 0.0000000000000000000000000000667 134.0
TLS2_k127_4859814_7 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000102 84.0
TLS2_k127_4881601_0 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005543 374.0
TLS2_k127_4881601_1 Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine K18911 - 2.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000004075 275.0
TLS2_k127_4881601_2 shikimate 3-dehydrogenase (NADP+) activity K00014,K13832 GO:0000166,GO:0003674,GO:0003824,GO:0003855,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25,4.2.1.10 0.0000000000000000000000000000000000000000001229 169.0
TLS2_k127_4881601_3 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.00000000000000000000000004045 115.0
TLS2_k127_4881601_4 Histidine ammonia-lyase K01745 - 4.3.1.3 0.000000102 65.0
TLS2_k127_4881950_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 3.876e-194 619.0
TLS2_k127_4881950_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300,K08301 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 417.0
TLS2_k127_4881950_2 ATP-dependent DNA helicase RecQ K03169 - 5.99.1.2 0.0000000000000000000000000000000000000000724 159.0
TLS2_k127_490361_0 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000003981 137.0
TLS2_k127_490361_1 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000189 117.0
TLS2_k127_490375_0 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000008724 136.0
TLS2_k127_490375_1 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000004554 117.0
TLS2_k127_4910662_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004323 454.0
TLS2_k127_4910662_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000001187 195.0
TLS2_k127_4910662_2 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000007547 183.0
TLS2_k127_4910662_3 Transglycosylase SLT domain K08309 - - 0.00000000000000000000004402 116.0
TLS2_k127_4910662_4 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - - 0.00006553 55.0
TLS2_k127_4919515_0 response regulator K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 390.0
TLS2_k127_4919515_1 Belongs to the peptidase S11 family K01286,K07258,K07262 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000004761 208.0
TLS2_k127_4919515_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07710 - 2.7.13.3 0.000000000000000000000000000000000001701 157.0
TLS2_k127_4919515_3 DoxX - - - 0.00000000000000000000000000000003773 132.0
TLS2_k127_4919515_5 DNA replication proofreading K02336,K06877,K07501 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.000000000000009593 76.0
TLS2_k127_4937160_0 Enoyl-CoA hydratase/isomerase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.00000000000000000000000000000000000000000000000000000000000000000451 236.0
TLS2_k127_4942057_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 315.0
TLS2_k127_4953677_0 PFAM NADH flavin oxidoreductase NADH oxidase K00219,K09461 - 1.14.13.40,1.3.1.34 2.152e-308 971.0
TLS2_k127_4953677_1 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K08295 - 6.2.1.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 614.0
TLS2_k127_4953677_2 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 355.0
TLS2_k127_4953677_3 enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002219 277.0
TLS2_k127_4953677_4 Belongs to the short-chain dehydrogenases reductases (SDR) family K00019,K07535 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000002159 237.0
TLS2_k127_4953677_5 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000001161 149.0
TLS2_k127_4953677_6 - - - - 0.000000000000000000000000000001112 132.0
TLS2_k127_4953677_7 - - - - 0.0000000000000000000000000004485 113.0
TLS2_k127_4955454_0 ABC-type transport system involved in Fe-S cluster assembly, permease component K09014 - - 2.792e-266 824.0
TLS2_k127_4955454_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000366 595.0
TLS2_k127_4955454_2 TIGRFAM FeS assembly ATPase SufC K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 377.0
TLS2_k127_4955454_3 FeS assembly protein SufD K07033,K09015 GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 396.0
TLS2_k127_4955454_4 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006346 258.0
TLS2_k127_4955454_5 2 iron, 2 sulfur cluster binding - - - 0.0000000000000000000000000000000000001302 165.0
TLS2_k127_4984683_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009569 341.0
TLS2_k127_4984683_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043142,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 331.0
TLS2_k127_4984683_2 Bacterial sugar transferase - - - 0.0000000000000000000000000000000000000000000000003819 177.0
TLS2_k127_4984683_3 Domain of unknown function (DUF3488) - - - 0.0000000000000000000000000000000000000000001824 185.0
TLS2_k127_4984683_4 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.0000000000000000000000000000000000000002851 162.0
TLS2_k127_4994774_0 Belongs to the sigma-70 factor family. ECF subfamily - - - 3.514e-204 642.0
TLS2_k127_4994774_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000002805 246.0
TLS2_k127_4994774_10 Protein of unknown function DUF86 - - - 0.000000000001765 80.0
TLS2_k127_4994774_11 HEAT repeats - - - 0.000000001301 70.0
TLS2_k127_4994774_2 - - - - 0.00000000000000000000000000000000000000000000000000000002698 209.0
TLS2_k127_4994774_3 - - - - 0.000000000000000000000000000000000000000000002567 183.0
TLS2_k127_4994774_4 S1/P1 Nuclease K05986 - 3.1.30.1 0.00000000000000000000000000000000000000664 158.0
TLS2_k127_4994774_5 - - - - 0.000000000000000000000000000000000002194 149.0
TLS2_k127_4994774_6 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000001398 153.0
TLS2_k127_4994774_7 Protein conserved in bacteria - - - 0.000000000000000000000000000000000816 135.0
TLS2_k127_4994774_8 actin binding - - - 0.000000000000000000000000007782 119.0
TLS2_k127_4994774_9 Nucleotidyltransferase domain - - - 0.0000000000000001536 87.0
TLS2_k127_4996616_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138,K18307 - - 1.273e-304 966.0
TLS2_k127_4996616_1 Uncharacterized protein conserved in bacteria (DUF2330) K00347,K21163 GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494 1.6.5.8 2.11e-255 807.0
TLS2_k127_4996616_10 Protein of unknown function (DUF3309) - - - 0.000000000005988 67.0
TLS2_k127_4996616_2 Sodium:sulfate symporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 604.0
TLS2_k127_4996616_3 ABC transporter, ATP-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 564.0
TLS2_k127_4996616_4 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 476.0
TLS2_k127_4996616_5 Biotin-lipoyl like K03585 - - 0.000000000000000000000000000000000000000000000000005932 198.0
TLS2_k127_4996616_6 Toxic component of a toxin-antitoxin (TA) module. An RNase K19686 - - 0.00000000000000000000000000000000000000000005175 169.0
TLS2_k127_4996616_7 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000001111 156.0
TLS2_k127_4996616_8 Cold shock protein domain K03704 - - 0.0000000000000000000000000000009574 124.0
TLS2_k127_4996616_9 Antitoxin component of a type II toxin-antitoxin (TA) system. Upon K19687 GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.0000000000000000000003445 99.0
TLS2_k127_5027131_0 pyruvate phosphate dikinase K01006 - 2.7.9.1 1.865e-286 899.0
TLS2_k127_5027131_1 NYN domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 295.0
TLS2_k127_5027131_2 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000000000000004283 217.0
TLS2_k127_5027131_3 Thioesterase superfamily K01075,K07107 - 3.1.2.23 0.00000000000000000000000000000005439 129.0
TLS2_k127_5027131_4 - - - - 0.000000000000003387 86.0
TLS2_k127_5027131_5 VanZ like family - - - 0.00000000003965 73.0
TLS2_k127_5048758_0 Short chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 576.0
TLS2_k127_5048758_1 COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes K08321,K11645 - 2.3.1.245,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 411.0
TLS2_k127_5048758_2 Domain of unknown function (DUF4143) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 391.0
TLS2_k127_5086089_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 376.0
TLS2_k127_5086089_1 PhoH-like protein K06217 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008599 351.0
TLS2_k127_5086089_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005964 352.0
TLS2_k127_5086089_3 7TM-HD extracellular K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 357.0
TLS2_k127_5100431_0 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005395 505.0
TLS2_k127_5122111_0 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 - 2.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 416.0
TLS2_k127_5122111_1 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 - 4.1.3.36 0.000000000000000000000001477 107.0
TLS2_k127_5122111_2 Isochorismate synthase K02361,K02552 - 5.4.4.2 0.0000004722 51.0
TLS2_k127_513253_0 Bacterial extracellular solute-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000001126 190.0
TLS2_k127_513253_1 Molybdate ABC transporter K02018 - - 0.00000000000000000000000005867 109.0
TLS2_k127_5143319_0 Horizontally Transferred TransMembrane Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009251 384.0
TLS2_k127_5143319_1 6-phosphogluconolactonase activity - - - 0.0000000000000000002737 103.0
TLS2_k127_5143319_2 PFAM ABC-2 type transporter K01992,K09690 - - 0.000000000000000004003 87.0
TLS2_k127_5143319_3 Protein of unknown function (DUF1573) - - - 0.0000000003322 72.0
TLS2_k127_5184998_0 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008836 572.0
TLS2_k127_5184998_1 amino acid transport K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 480.0
TLS2_k127_5184998_2 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 445.0
TLS2_k127_5184998_3 Phosphorylase superfamily K01241 - 3.2.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 429.0
TLS2_k127_5184998_4 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 372.0
TLS2_k127_5184998_5 Methionine biosynthesis protein MetW K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000546 268.0
TLS2_k127_5184998_6 Peptidase family S51 - - - 0.00000000000000000000000000000000000000000000000000000002266 209.0
TLS2_k127_5184998_7 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000355 184.0
TLS2_k127_5184998_8 - - - - 0.000000000000000002016 89.0
TLS2_k127_5201799_0 ATPases associated with a variety of cellular activities K09689,K09691 - 3.6.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 326.0
TLS2_k127_5201799_1 Arylsulfotransferase (ASST) - - - 0.0000000002189 62.0
TLS2_k127_5201799_2 transferase activity, transferring acyl groups - - - 0.0000003613 63.0
TLS2_k127_52103_0 PFAM ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 405.0
TLS2_k127_52103_1 Male sterility protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 287.0
TLS2_k127_5224070_0 Thioesterase domain - - - 0.0 1128.0
TLS2_k127_522488_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 465.0
TLS2_k127_522488_1 Pfam AhpC TSA family - - - 0.0000000000000000000000000000001434 132.0
TLS2_k127_522488_2 Domain of unknown function (DU1801) - - - 0.0000000000000003509 81.0
TLS2_k127_522488_3 Transcriptional regulator PadR-like family - - - 0.000000000118 62.0
TLS2_k127_522685_0 ThiF family K21029,K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000000000000000000000000000000000007918 225.0
TLS2_k127_522685_1 Protein of unknown function (DUF1702) - - - 0.000000000000000000000000000000000000000000451 163.0
TLS2_k127_522685_2 proteolysis - - - 0.00000000000000000000000000000001309 133.0
TLS2_k127_5227541_0 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 475.0
TLS2_k127_5227541_1 Phage integrase, N-terminal SAM-like domain K03733,K04763 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000001985 148.0
TLS2_k127_5227541_2 Lrp/AsnC ligand binding domain - - - 0.00000000000000000000002039 111.0
TLS2_k127_5256978_0 Sodium:solute symporter family K14392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 397.0
TLS2_k127_5256978_1 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000005726 221.0
TLS2_k127_5294489_0 L,D-transpeptidase catalytic domain K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 383.0
TLS2_k127_5294489_1 protein conserved in bacteria K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003003 359.0
TLS2_k127_5294489_2 Belongs to the FPP GGPP synthase family K00805,K02523 - 2.5.1.30,2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000006631 274.0
TLS2_k127_5294489_3 spore germination - - - 0.0000000000000000000000000000000000000000000000000000000008949 209.0
TLS2_k127_5294489_4 DEAD DEAH box helicase domain protein K06877 - - 0.0000000000000000000000000000000000000000008043 160.0
TLS2_k127_5294489_5 heme binding K21472 - - 0.0000000000000000001518 99.0
TLS2_k127_5294489_6 Late embryogenesis abundant protein - - - 0.0000000000000003354 86.0
TLS2_k127_5295912_0 3-oxoacyl-[acyl-carrier-protein] synthase activity K09458,K18473 - 2.3.1.179,2.3.1.180 6.121e-217 716.0
TLS2_k127_5295912_1 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 395.0
TLS2_k127_5295912_2 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 370.0
TLS2_k127_5295912_3 Competence-damaged protein K03742,K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 301.0
TLS2_k127_5295912_4 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007676 289.0
TLS2_k127_5295912_5 PFAM phosphoesterase, RecJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001603 239.0
TLS2_k127_5295912_6 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000001897 120.0
TLS2_k127_5295912_7 Protein of unknown function, DUF547 - - - 0.00000004734 59.0
TLS2_k127_5295912_8 GDSL-like Lipase/Acylhydrolase family K02014 - - 0.0007069 53.0
TLS2_k127_5297748_0 Amino acid adenylation domain - - - 0.0 1305.0
TLS2_k127_5297827_0 Amino acid adenylation domain - - - 0.0 1324.0
TLS2_k127_5297827_1 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 560.0
TLS2_k127_5330817_0 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 460.0
TLS2_k127_5330817_1 Phosphopantetheine attachment site K02078 - - 0.000002653 55.0
TLS2_k127_533568_0 PFAM Type II secretion system protein E K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 329.0
TLS2_k127_533568_1 oxidoreductase activity - - - 0.00000000000000000000000000003766 136.0
TLS2_k127_533568_2 - - - - 0.000000000000000000000000008169 117.0
TLS2_k127_533568_3 guanyl-nucleotide exchange factor activity K15125 - - 0.00000001212 66.0
TLS2_k127_533568_4 metalloendopeptidase activity - - - 0.0005769 54.0
TLS2_k127_5339233_0 DNA polymerase K02337 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 428.0
TLS2_k127_5339233_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000178 279.0
TLS2_k127_5339233_2 Competence protein ComEC K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000009124 243.0
TLS2_k127_5339233_3 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.000000000000000000000000001647 122.0
TLS2_k127_5339233_4 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000003501 72.0
TLS2_k127_53420_0 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004142 406.0
TLS2_k127_53420_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000003383 233.0
TLS2_k127_53420_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000008726 204.0
TLS2_k127_53420_3 Cold-shock protein K03704 - - 0.0000000000000000000001601 100.0
TLS2_k127_53420_4 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000004076 77.0
TLS2_k127_53420_5 Protein of unknown function (DUF971) - - - 0.00000000005594 63.0
TLS2_k127_53420_6 Preprotein translocase SecG subunit K03075 - - 0.0000000001224 73.0
TLS2_k127_53420_7 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000001871 59.0
TLS2_k127_5345026_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007854 526.0
TLS2_k127_5345026_1 Serine kinase of the HPr protein, regulates carbohydrate metabolism - - - 0.000004502 56.0
TLS2_k127_538635_0 Polysaccharide biosynthesis protein K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 547.0
TLS2_k127_538635_1 modulates the activities of several proteins which are inactive in their K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 338.0
TLS2_k127_538635_2 PIN domain K07064 - - 0.000004304 54.0
TLS2_k127_538635_3 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0001969 49.0
TLS2_k127_5422280_0 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 477.0
TLS2_k127_5422765_0 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000009029 272.0
TLS2_k127_5422765_1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000001999 164.0
TLS2_k127_5422765_2 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000004737 165.0
TLS2_k127_5422765_3 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.000000000000000000000000000000004453 137.0
TLS2_k127_5422765_4 KH domain K06960 - - 0.00000000125 60.0
TLS2_k127_5430170_0 ATPase associated with various cellular K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008573 383.0
TLS2_k127_5430170_1 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000499 277.0
TLS2_k127_54412_0 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 533.0
TLS2_k127_54412_1 neurotransmitter:sodium symporter activity K03308,K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009737 490.0
TLS2_k127_54412_2 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000007411 228.0
TLS2_k127_54412_3 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000000047 126.0
TLS2_k127_54412_4 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000004115 134.0
TLS2_k127_54703_0 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007936 389.0
TLS2_k127_54703_1 hydroxymethylglutaryl-CoA reductase K00021 - 1.1.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000442 318.0
TLS2_k127_5489307_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000002959 219.0
TLS2_k127_5489307_1 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000000000000000000000000000008298 177.0
TLS2_k127_5489307_2 COGs COG1253 Hemolysins and related protein containing CBS domains - - - 0.0000000000000000002438 90.0
TLS2_k127_5489307_3 Fungalysin metallopeptidase (M36) K01417 - - 0.0001775 55.0
TLS2_k127_55040_0 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005766 278.0
TLS2_k127_55040_1 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000006002 214.0
TLS2_k127_55040_2 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000000000001461 191.0
TLS2_k127_55040_3 PFAM Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000004259 136.0
TLS2_k127_55040_4 Glycosyl transferases group 1 K21001 - - 0.0000000000000000000000000000001432 138.0
TLS2_k127_55040_5 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.00000000000000000000002855 108.0
TLS2_k127_55040_6 PFAM PIN domain - - - 0.00000000000006797 76.0
TLS2_k127_55040_7 - - - - 0.00001434 55.0
TLS2_k127_5512492_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000000002867 256.0
TLS2_k127_5512492_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.0000002183 63.0
TLS2_k127_5560664_0 UDP-3-O-acyl N-acetylglycosamine deacetylase K02535,K13599 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005319 368.0
TLS2_k127_5560664_1 - - - - 0.00000000001153 70.0
TLS2_k127_5594461_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008497 370.0
TLS2_k127_5597902_0 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 301.0
TLS2_k127_5597902_1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000217 277.0
TLS2_k127_5611309_0 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 380.0
TLS2_k127_5617786_0 serine-type peptidase activity K01303,K12132 - 2.7.11.1,3.4.19.1 1.994e-205 689.0
TLS2_k127_5617786_1 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000004539 267.0
TLS2_k127_5617786_2 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000639 204.0
TLS2_k127_5617786_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000107 74.0
TLS2_k127_5617786_4 KR domain - - - 0.00000001102 62.0
TLS2_k127_5617786_5 PFAM Sporulation and spore germination - - - 0.00000001637 68.0
TLS2_k127_5618587_0 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002612 290.0
TLS2_k127_5618587_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000002701 269.0
TLS2_k127_5620177_0 ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006877 312.0
TLS2_k127_5620177_1 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.0000000000000001934 84.0
TLS2_k127_5620177_2 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.00000002266 63.0
TLS2_k127_5620177_3 amino acid - - - 0.0000003592 53.0
TLS2_k127_5621932_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 9.64e-236 737.0
TLS2_k127_5621932_1 Protein of unknown function (DUF1116) K02381 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 409.0
TLS2_k127_5621932_2 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007513 383.0
TLS2_k127_5628000_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 354.0
TLS2_k127_5628000_1 Sugar (and other) transporter K08151 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 324.0
TLS2_k127_5628000_2 PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic K01886 - 6.1.1.18 0.00000000000000000000000000000000000000005799 153.0
TLS2_k127_5630554_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 575.0
TLS2_k127_5630554_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 451.0
TLS2_k127_5630554_2 PFAM SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000001144 188.0
TLS2_k127_5630554_3 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K12980 - - 0.00002545 56.0
TLS2_k127_563315_0 LVIVD repeat - - - 0.0 1371.0
TLS2_k127_563315_1 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000001819 197.0
TLS2_k127_563315_2 FG-GAP repeat - - - 0.0000000000003975 76.0
TLS2_k127_5640100_0 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000001028 147.0
TLS2_k127_5640100_1 GAF domain - - - 0.0000000000000000000000000000000002173 136.0
TLS2_k127_5650410_0 PFAM Carbamoyltransferase K00612 - - 1.335e-237 757.0
TLS2_k127_5650410_1 membrane-bound lytic murein transglycosylase K08304 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009503 447.0
TLS2_k127_5650410_10 - - - - 0.0006089 44.0
TLS2_k127_5650410_2 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 378.0
TLS2_k127_5650410_3 SCO1/SenC K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 364.0
TLS2_k127_5650410_4 Multicopper oxidase K22350 - 1.16.3.3 0.0000000000000000000000000000000000000000000000000000000000000000005219 230.0
TLS2_k127_5650410_5 water channel activity K02440,K06188 - - 0.000000000000000000000000000000000000000000000000000000005167 206.0
TLS2_k127_5650410_6 PRC-barrel domain - - - 0.00000000000000000000000000000000000000002059 162.0
TLS2_k127_5650410_7 Lecithin:cholesterol acyltransferase - - - 0.00000000000000000000000000000003371 145.0
TLS2_k127_5650410_8 transcriptional regulator containing an HTH domain fused to a Zn-ribbon K07743 - - 0.00000000000037 76.0
TLS2_k127_5650410_9 - - - - 0.0002417 50.0
TLS2_k127_5651298_0 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004152 513.0
TLS2_k127_5651298_1 Aldehyde dehydrogenase family K02618,K15514 - 1.2.1.77,1.2.1.91,3.3.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 442.0
TLS2_k127_5651298_2 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000001093 144.0
TLS2_k127_5651298_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000001681 75.0
TLS2_k127_5654012_0 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000164 145.0
TLS2_k127_5654012_1 Protein of unknown function (DUF1579) - - - 0.0000008214 53.0
TLS2_k127_5665567_0 Na H antiporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 533.0
TLS2_k127_5665567_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000004338 238.0
TLS2_k127_5666192_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004271 268.0
TLS2_k127_5666192_1 - - - - 0.0000000000000000000000000000004342 144.0
TLS2_k127_5666192_3 TonB dependent receptor K02014 - - 0.0000000000000003857 87.0
TLS2_k127_5673586_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 529.0
TLS2_k127_5673586_1 FecR protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 431.0
TLS2_k127_5673586_10 - - - - 0.00000000000000000000000000000000000000004923 163.0
TLS2_k127_5673586_11 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000887 138.0
TLS2_k127_5673586_14 NlpC/P60 family K19224,K21471 - - 0.00003212 55.0
TLS2_k127_5673586_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006703 428.0
TLS2_k127_5673586_3 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 398.0
TLS2_k127_5673586_4 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006464 368.0
TLS2_k127_5673586_5 PFAM periplasmic solute binding protein K09815 - - 0.0000000000000000000000000000000000000000000000000001545 197.0
TLS2_k127_5673586_6 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.0000000000000000000000000000000000000000000000000004051 195.0
TLS2_k127_5673586_7 PFAM Appr-1-p processing domain protein - - - 0.0000000000000000000000000000000000000000000000000086 186.0
TLS2_k127_5673586_8 - - - - 0.000000000000000000000000000000000000000000000001003 196.0
TLS2_k127_5673586_9 arylsulfatase activity - - - 0.000000000000000000000000000000000000000001403 175.0
TLS2_k127_5678786_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000005385 242.0
TLS2_k127_5678786_2 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000001623 133.0
TLS2_k127_570350_0 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002489 298.0
TLS2_k127_570350_1 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003936 250.0
TLS2_k127_5720770_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008169 551.0
TLS2_k127_5720770_1 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 324.0
TLS2_k127_5720770_10 - - - - 0.000000000000000000000000001098 119.0
TLS2_k127_5720770_11 COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain - - - 0.000000000000000000009392 106.0
TLS2_k127_5720770_12 PhoU domain - - - 0.00000000000004092 80.0
TLS2_k127_5720770_13 Peptidase C14 caspase catalytic subunit p20 - - - 0.000000196 63.0
TLS2_k127_5720770_14 Plasmid stabilization system - - - 0.0003847 46.0
TLS2_k127_5720770_15 CoA binding domain - - - 0.0006926 49.0
TLS2_k127_5720770_2 phosphate symporter K14683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007588 315.0
TLS2_k127_5720770_3 Co Zn Cd cation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002145 297.0
TLS2_k127_5720770_4 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000002544 259.0
TLS2_k127_5720770_5 2,3-bisphosphoglycerate-independent phosphoglycerate mutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009084 276.0
TLS2_k127_5720770_6 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000008795 232.0
TLS2_k127_5720770_7 ATP cone domain K05715 - - 0.00000000000000000000000000000000000000000000001803 195.0
TLS2_k127_5720770_8 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.000000000000000000000000000000000000000000000209 177.0
TLS2_k127_5720770_9 TIR domain - - - 0.000000000000000000000000000000007893 145.0
TLS2_k127_5731396_0 Electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000724 224.0
TLS2_k127_5731396_1 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.00000000000000000000000000000000000000000000001838 190.0
TLS2_k127_5737566_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 2.784e-243 760.0
TLS2_k127_5737566_1 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 379.0
TLS2_k127_5737566_10 Type IV Pilus-assembly protein W K02672 - - 0.00004561 56.0
TLS2_k127_5737566_2 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 356.0
TLS2_k127_5737566_3 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.000000000000000000000000000005636 140.0
TLS2_k127_5737566_4 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000003157 107.0
TLS2_k127_5737566_5 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000002418 102.0
TLS2_k127_5737566_6 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000001589 76.0
TLS2_k127_5737566_7 transposase or invertase - - - 0.0000000000189 76.0
TLS2_k127_5737566_8 Tetratricopeptide repeat - - - 0.000001197 61.0
TLS2_k127_5737566_9 domain, Protein - - - 0.000005631 55.0
TLS2_k127_5752563_0 Large extracellular alpha-helical protein - - - 0.0 1142.0
TLS2_k127_5752563_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.000002436 52.0
TLS2_k127_5786503_0 Protein tyrosine kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000000000000000000000000002859 134.0
TLS2_k127_5786503_1 Poly(hydroxyalcanoate) granule associated protein (phasin) - - - 0.00000000001494 78.0
TLS2_k127_5786868_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 577.0
TLS2_k127_5786868_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009626 359.0
TLS2_k127_5786868_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000242 216.0
TLS2_k127_5786868_3 HAD-superfamily hydrolase, subfamily IA, variant 3 K01091 - 3.1.3.18 0.00000000000000000000000000000000003079 155.0
TLS2_k127_5786868_4 Amino acid kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.000000000000000000000000000005205 123.0
TLS2_k127_5786868_5 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000000002156 107.0
TLS2_k127_5786868_6 - - - - 0.000000000000000002903 91.0
TLS2_k127_5790803_0 CoA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007386 513.0
TLS2_k127_5790803_1 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005284 480.0
TLS2_k127_5790803_10 Sulfotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001938 234.0
TLS2_k127_5790803_11 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family - - - 0.000000000000000000000000000000000000000000000000000000000001078 228.0
TLS2_k127_5790803_12 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000781 225.0
TLS2_k127_5790803_13 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000005851 200.0
TLS2_k127_5790803_14 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000001759 199.0
TLS2_k127_5790803_15 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000004144 192.0
TLS2_k127_5790803_16 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000004283 171.0
TLS2_k127_5790803_17 - - - - 0.00000000000000000000000000000000000000003253 172.0
TLS2_k127_5790803_19 Lipopolysaccharide biosynthesis protein K19424 - - 0.00000000000000000000000000000006528 146.0
TLS2_k127_5790803_2 Glutamine amidotransferase domain K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008611 427.0
TLS2_k127_5790803_20 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000003385 134.0
TLS2_k127_5790803_21 O-methyltransferase activity K00588 - 2.1.1.104 0.0000000000000000000000002959 123.0
TLS2_k127_5790803_22 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.000000000000000000000003687 113.0
TLS2_k127_5790803_23 polysaccharide deacetylase - - - 0.0000000000000003557 93.0
TLS2_k127_5790803_24 Methyltransferase FkbM domain - - - 0.000000000000009018 89.0
TLS2_k127_5790803_25 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis - - - 0.0000000000001008 83.0
TLS2_k127_5790803_26 Glycosyltransferase like family 2 K07011 - - 0.00000000005021 74.0
TLS2_k127_5790803_27 Polysaccharide biosynthesis protein K03328 - - 0.0000000003305 68.0
TLS2_k127_5790803_28 - - - - 0.0000003463 54.0
TLS2_k127_5790803_29 - - - - 0.0000003721 64.0
TLS2_k127_5790803_3 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004451 301.0
TLS2_k127_5790803_30 Uncharacterised nucleotidyltransferase - - - 0.0000003942 63.0
TLS2_k127_5790803_4 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 312.0
TLS2_k127_5790803_5 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001498 308.0
TLS2_k127_5790803_6 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002328 275.0
TLS2_k127_5790803_7 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005228 282.0
TLS2_k127_5790803_8 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000004726 254.0
TLS2_k127_5790803_9 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000006748 252.0
TLS2_k127_5798122_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 6.093e-222 699.0
TLS2_k127_5798122_1 4Fe-4S dicluster domain K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000002683 259.0
TLS2_k127_5800240_0 Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine K18912 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0019439,GO:0019752,GO:0034641,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0055114,GO:0071704,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 1.14.99.50 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 459.0
TLS2_k127_5800240_1 Glycine betaine K05845 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000825 347.0
TLS2_k127_5800240_2 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 304.0
TLS2_k127_5800240_3 protein conserved in bacteria - - - 0.0000000000000000000000000563 112.0
TLS2_k127_5800240_4 S4 RNA-binding domain K04762 - - 0.000000000000000001073 90.0
TLS2_k127_5800240_5 Protein of unknown function (DUF1328) - - - 0.000000000000001424 77.0
TLS2_k127_580093_0 Tricorn protease homolog K08676 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 307.0
TLS2_k127_580093_1 thiolester hydrolase activity - - - 0.00000000175 70.0
TLS2_k127_580093_2 Phosphate acyltransferases - - - 0.000003349 51.0
TLS2_k127_5809357_0 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 580.0
TLS2_k127_5809357_1 cellular modified histidine biosynthetic process K18802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001199 272.0
TLS2_k127_5809357_2 S1/P1 Nuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001844 254.0
TLS2_k127_5809357_3 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000004077 152.0
TLS2_k127_5809357_5 Protein of unknown function (DUF2911) - - - 0.000000000000000000000000000002431 129.0
TLS2_k127_5809357_6 PFAM Smr protein MutS2 - - - 0.000000000000000004736 99.0
TLS2_k127_5809357_7 Domain of unknown function (DUF309) K09763 - - 0.00000000003701 76.0
TLS2_k127_5809357_8 Carboxypeptidase regulatory-like domain - - - 0.0004956 52.0
TLS2_k127_5810533_0 competence protein - - - 0.0004566 43.0
TLS2_k127_5815970_0 Molecular chaperone. Has ATPase activity K04079 GO:0000302,GO:0000303,GO:0000305,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0010035,GO:0016020,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071450,GO:0071451,GO:0071944,GO:1901700,GO:1901701 - 8.47e-198 636.0
TLS2_k127_5815970_1 lysine 2,3-aminomutase K19810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 447.0
TLS2_k127_5815970_2 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005938 339.0
TLS2_k127_5815970_3 3'-5' exonuclease activity - - - 0.000000000000000000000000000000000000000000000000000000000000001226 229.0
TLS2_k127_5815970_4 diguanylate cyclase - - - 0.00000000000000000000000000000000000001415 159.0
TLS2_k127_5815970_5 Domain of unknown function (DUF4203) - - - 0.00000000000000002625 91.0
TLS2_k127_5815970_6 - - - - 0.00008682 56.0
TLS2_k127_5819412_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000818 312.0
TLS2_k127_5819412_1 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000001071 149.0
TLS2_k127_5819540_0 DEAD/H associated K03724 - - 5.315e-194 623.0
TLS2_k127_5822027_0 PFAM conserved - - - 0.00000000000000000000000000000000006714 151.0
TLS2_k127_5822027_1 - - - - 0.000000000000000001436 92.0
TLS2_k127_5822367_0 extracellular solute-binding protein, family 5 K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001096 293.0
TLS2_k127_5822367_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002646 272.0
TLS2_k127_5822367_2 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000459 271.0
TLS2_k127_5822367_3 Protoglobin - - - 0.00000000000000000000000000002364 132.0
TLS2_k127_5845155_0 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008724 340.0
TLS2_k127_5845155_1 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001233 274.0
TLS2_k127_5845155_2 Flavin-nucleotide-binding protein K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007006 250.0
TLS2_k127_5845155_3 Phosphotransferase enzyme family - - - 0.000000000000000000000001328 106.0
TLS2_k127_5860736_0 Belongs to the malate synthase family K01638 - 2.3.3.9 2.158e-269 841.0
TLS2_k127_5861599_0 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 620.0
TLS2_k127_5861599_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000004048 142.0
TLS2_k127_5861599_2 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000004618 133.0
TLS2_k127_5863379_0 Domain of unknown function (DUF4301) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004268 413.0
TLS2_k127_5863379_1 FR47-like protein - - - 0.0000000000000000000000000000000000000000000003438 173.0
TLS2_k127_5863379_2 - - - - 0.0000000000000118 83.0
TLS2_k127_5865159_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 530.0
TLS2_k127_5865159_1 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 559.0
TLS2_k127_5865159_2 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006762 434.0
TLS2_k127_5865159_3 4-amino-4-deoxy-L-arabinose transferase activity K02277 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000222 199.0
TLS2_k127_5865159_4 nuclease activity K06218 - - 0.000000000000006771 77.0
TLS2_k127_5865159_5 - - - - 0.00000001457 59.0
TLS2_k127_5865159_6 - - - - 0.0000003988 56.0
TLS2_k127_5875370_0 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000001527 190.0
TLS2_k127_5875370_1 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.00000000000000000000000000000000000009348 151.0
TLS2_k127_5875370_2 KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000946 132.0
TLS2_k127_5875370_3 Protein of unknown function (DUF1572) - - - 0.00000000000000000000000001567 122.0
TLS2_k127_5875370_4 - - - - 0.00000000000000000000008923 105.0
TLS2_k127_5875370_5 PFAM von Willebrand factor type A - - - 0.0000000000204 67.0
TLS2_k127_587654_0 IgA Peptidase M64 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004605 292.0
TLS2_k127_587654_1 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000007532 161.0
TLS2_k127_5889054_0 Non-ribosomal peptide synthetase modules and related - - - 0.0 2813.0
TLS2_k127_5889054_1 Acyl transferase domain in polyketide synthase (PKS) enzymes. - - - 1.81e-272 947.0
TLS2_k127_5889054_2 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007523 505.0
TLS2_k127_5889054_3 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 484.0
TLS2_k127_5889054_4 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 407.0
TLS2_k127_5889054_5 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 373.0
TLS2_k127_5889054_6 PFAM aminotransferase class I and II K05825 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 374.0
TLS2_k127_5889054_7 of the alpha beta superfamily K06889 - - 0.0000000000000000000000000008322 121.0
TLS2_k127_5889054_8 - - - - 0.000002323 57.0
TLS2_k127_5898138_0 Involved in the tonB-independent uptake of proteins K01256,K03641 - 3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 437.0
TLS2_k127_5910755_0 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000002031 220.0
TLS2_k127_5910755_1 (ABC) transporter K15738 - - 0.000000000000000000000000000001188 126.0
TLS2_k127_591134_0 NAD dependent epimerase dehydratase family K19180 - 1.1.1.339 0.0000000000000000000000000000000000000000000000000000000000000000000000000009383 268.0
TLS2_k127_591134_1 Polysaccharide biosynthesis protein - - - 0.00000000007664 75.0
TLS2_k127_5918190_0 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 349.0
TLS2_k127_5918190_1 PFAM Aspartate glutamate uridylate kinase K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 295.0
TLS2_k127_5918190_2 Amidinotransferase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000114 244.0
TLS2_k127_5918190_3 - - - - 0.0000000000000000005342 88.0
TLS2_k127_5925221_0 Glutamate-cysteine ligase family 2(GCS2) - - - 1.771e-219 698.0
TLS2_k127_5925221_1 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 565.0
TLS2_k127_5925221_2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006514 481.0
TLS2_k127_5925221_3 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 358.0
TLS2_k127_5925221_4 NAD(P)+ transhydrogenase (AB-specific) activity K00324 - 1.6.1.2 0.00000000000000000000000000000002076 130.0
TLS2_k127_5925221_5 - - - - 0.0000000000000006872 86.0
TLS2_k127_5925221_6 Zinc-dependent metalloprotease K01388 - 3.4.24.7 0.0000007793 59.0
TLS2_k127_5929916_0 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 550.0
TLS2_k127_5929916_1 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000002818 271.0
TLS2_k127_5956626_0 cell shape determining protein MreB K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 533.0
TLS2_k127_5956626_1 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 443.0
TLS2_k127_5956626_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001081 278.0
TLS2_k127_5956626_3 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000037 130.0
TLS2_k127_5956626_4 diguanylate cyclase - - - 0.0000000000000000000003952 98.0
TLS2_k127_5956626_5 shape-determining protein MreD K03571 - - 0.0003158 49.0
TLS2_k127_5958315_0 PhoD-like phosphatase K01113 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000009081 270.0
TLS2_k127_5958315_1 - - - - 0.0000000000000000000000000000007382 134.0
TLS2_k127_5958315_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000001415 122.0
TLS2_k127_5978963_0 PFAM Type II secretion system protein E K02454,K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 440.0
TLS2_k127_5978963_1 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 325.0
TLS2_k127_5978963_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000001692 233.0
TLS2_k127_5978963_3 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.00000000000000000000000000000005663 132.0
TLS2_k127_5979623_0 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005933 442.0
TLS2_k127_5979623_1 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003168 271.0
TLS2_k127_5979623_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001101 258.0
TLS2_k127_5979623_3 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000001158 235.0
TLS2_k127_5981625_0 Protein conserved in bacteria - - - 0.00000000000000000000000001228 125.0
TLS2_k127_5993148_0 cytochrome C peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001589 287.0
TLS2_k127_5993148_1 PFAM MCP methyltransferase CheR-type K00575 - 2.1.1.80 0.0000000000000000000000000000000000005261 154.0
TLS2_k127_599771_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 3.921e-218 687.0
TLS2_k127_599771_1 Involved in the tonB-independent uptake of proteins K01256,K03641 - 3.4.11.2 0.000000000000000000000000000008244 134.0
TLS2_k127_6003203_0 MacB-like periplasmic core domain - - - 4.007e-317 990.0
TLS2_k127_6003203_1 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 337.0
TLS2_k127_6003203_2 PFAM OsmC family protein - - - 0.000000000000000000000000000000000000000000000000000005515 194.0
TLS2_k127_6003368_0 ATPase activity K01990,K13582,K20459,K20491 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 477.0
TLS2_k127_6003368_1 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000001123 233.0
TLS2_k127_6003368_2 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000008245 115.0
TLS2_k127_6003368_3 cheY-homologous receiver domain - - - 0.00000000000002394 81.0
TLS2_k127_6003368_4 3'-5' exonuclease activity - - - 0.0000004227 59.0
TLS2_k127_6003547_0 COG0189 Glutathione synthase Ribosomal protein S6 modification K05844 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005054 351.0
TLS2_k127_6003547_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K07250 - 2.6.1.19,2.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 342.0
TLS2_k127_6003547_2 Peptidase family S49 K04773,K04774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 327.0
TLS2_k127_6003547_3 succinylglutamate desuccinylase aspartoacylase K06987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006006 307.0
TLS2_k127_6003547_4 A G-specific adenine glycosylase K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005887 286.0
TLS2_k127_6003547_5 dTDP biosynthetic process K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000002594 233.0
TLS2_k127_6003547_6 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000004863 217.0
TLS2_k127_6003547_7 Putative ATP-dependant zinc protease - - - 0.00000000000000000000000000004051 125.0
TLS2_k127_6003547_8 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000001398 103.0
TLS2_k127_6003547_9 PFAM Cyclic nucleotide-binding K10914 - - 0.000000004145 68.0
TLS2_k127_6003568_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 493.0
TLS2_k127_6008071_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261,K00262 - 1.4.1.3,1.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 328.0
TLS2_k127_6008071_1 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000653 200.0
TLS2_k127_6008071_2 - - - - 0.0000000000000000003279 94.0
TLS2_k127_6008071_3 peptidyl-tyrosine sulfation - - - 0.000000000000007985 89.0
TLS2_k127_6008071_4 Protein of unknown function (DUF2752) - - - 0.000000001783 68.0
TLS2_k127_6010255_0 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000005379 192.0
TLS2_k127_6010255_1 CHRD domain - - - 0.0000000000000000000000000000000000000000005421 164.0
TLS2_k127_6010255_2 DoxX - - - 0.0000000000000000000000000000001891 129.0
TLS2_k127_6010255_3 PIN domain K07064 - - 0.00000000000000000000001231 108.0
TLS2_k127_6010255_4 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000001627 52.0
TLS2_k127_6016902_0 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000001228 175.0
TLS2_k127_6016902_1 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000001034 164.0
TLS2_k127_601893_0 metallopeptidase activity K16922 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001 297.0
TLS2_k127_601893_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000007844 229.0
TLS2_k127_601893_2 phosphoserine phosphatase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.0000000000000000000000000000000000000000000000000002433 208.0
TLS2_k127_601893_3 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02667 - - 0.00000000000000000000001055 105.0
TLS2_k127_601893_4 antisigma factor binding - - - 0.0000000000000000000001419 102.0
TLS2_k127_601893_5 PFAM Prenyltransferase squalene oxidase K06045,K17811 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009267,GO:0009605,GO:0009607,GO:0009975,GO:0009987,GO:0009991,GO:0010350,GO:0016101,GO:0016102,GO:0016114,GO:0016853,GO:0016872,GO:0019637,GO:0031667,GO:0031668,GO:0031669,GO:0033385,GO:0033554,GO:0035439,GO:0035440,GO:0042594,GO:0043167,GO:0043169,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071496,GO:0071704,GO:0075136,GO:1901576 4.2.1.129,5.4.99.17,5.5.1.16 0.000000000000000004375 91.0
TLS2_k127_601893_6 PFAM ATP-binding region, ATPase domain protein K04757 - 2.7.11.1 0.00000008219 62.0
TLS2_k127_6027685_0 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009917 441.0
TLS2_k127_6027685_1 Putative esterase K07214 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004135 317.0
TLS2_k127_6027685_2 Belongs to the D-alanine--D-alanine ligase family - - - 0.000000000103 74.0
TLS2_k127_6031394_0 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000001571 138.0
TLS2_k127_6031394_1 peptidyl-tyrosine sulfation - - - 0.000000000001345 79.0
TLS2_k127_6031394_2 Roadblock/LC7 domain - - - 0.0000005351 61.0
TLS2_k127_6041915_0 Cytochrome C assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 617.0
TLS2_k127_6041915_1 - - - - 0.00000000000000000000000000000000000000000000000000000007721 210.0
TLS2_k127_6041915_2 Putative bacterial lipoprotein (DUF799) - - - 0.0000000000000000000000000005067 120.0
TLS2_k127_6041915_3 - - - - 0.000001132 62.0
TLS2_k127_6054896_0 aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000005698 248.0
TLS2_k127_6054896_1 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.00000000000000000000000000000000000001257 148.0
TLS2_k127_6054896_2 RES domain - - - 0.00000000000000000000000000000007192 132.0
TLS2_k127_6054896_3 - - - - 0.000000008617 68.0
TLS2_k127_6054896_4 - - - - 0.00000004015 64.0
TLS2_k127_6054896_5 domain protein - - - 0.000001392 60.0
TLS2_k127_6065177_0 glycosyl transferase group 1 K12994 - 2.4.1.349 0.00000000000000000000000000000000000000000000000006653 203.0
TLS2_k127_6065177_1 glycosyl transferase group 1 K00786,K12994 - 2.4.1.349 0.000000000000000000000000000000000000008297 163.0
TLS2_k127_6065177_2 Domain of unknown function (DUF4214) - - - 0.0000000000000000000000000001804 121.0
TLS2_k127_6088212_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000904 414.0
TLS2_k127_6088815_0 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.0000000000000000000000000001373 131.0
TLS2_k127_6088815_1 N-Acetylmuramoyl-L-alanine amidase K01448,K02172 - 3.5.1.28 0.0000003901 62.0
TLS2_k127_611031_0 UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 481.0
TLS2_k127_611031_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.000000000000000000000000000000005432 141.0
TLS2_k127_611031_2 proteolysis - - - 0.0000000000000000000000000000005868 126.0
TLS2_k127_6111951_0 Cytochrome c3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 310.0
TLS2_k127_6111951_1 denitrification pathway - - - 0.0000000000000000000000000000000000000000000000000000000000000002844 232.0
TLS2_k127_6111951_2 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000000000000000001774 194.0
TLS2_k127_6111951_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000003018 142.0
TLS2_k127_6111951_4 response regulator K02282 - - 0.0000000000001373 71.0
TLS2_k127_6111951_7 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000005735 55.0
TLS2_k127_6111951_8 peptidase M48, Ste24p - - - 0.000003461 60.0
TLS2_k127_6127755_0 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007202 258.0
TLS2_k127_6127755_1 Von Willebrand factor type A domain K07114 - - 0.00000000000000000000000000000000000000004315 173.0
TLS2_k127_6127755_2 Oxygen tolerance - - - 0.0000000000000000003284 103.0
TLS2_k127_6127755_3 Tetratricopeptide repeat - - - 0.000005403 59.0
TLS2_k127_6129464_0 PFAM biotin lipoyl attachment domain-containing protein K00382 - 1.8.1.4 1.869e-195 644.0
TLS2_k127_6129464_1 ATP-dependent DNA helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 554.0
TLS2_k127_6129464_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 454.0
TLS2_k127_6129464_3 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000003222 186.0
TLS2_k127_6129464_4 - - - - 0.000000000000000000000000000000007296 130.0
TLS2_k127_6129464_5 Protein of unknown function (DUF433) - - - 0.0000000000000000000000165 102.0
TLS2_k127_6129464_6 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.000000000001516 67.0
TLS2_k127_6139846_0 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003167 527.0
TLS2_k127_6139846_1 Pfam Transposase IS66 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 382.0
TLS2_k127_6139846_2 dipeptide transport K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004794 295.0
TLS2_k127_6139846_3 FMN binding K03612 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000001098 137.0
TLS2_k127_6139846_5 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000002209 80.0
TLS2_k127_6146079_0 Bacterial regulatory protein, Fis family K02584 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 378.0
TLS2_k127_6146079_1 pathogenesis - - - 0.0000000000003093 75.0
TLS2_k127_6190219_0 PFAM sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003003 548.0
TLS2_k127_6190219_1 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 0.0000000000000000000000000000000000000000000000000000001496 197.0
TLS2_k127_6190619_0 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000007124 146.0
TLS2_k127_6190619_1 efflux transmembrane transporter activity - - - 0.000000000000003557 79.0
TLS2_k127_6190619_2 - - - - 0.00000002458 59.0
TLS2_k127_6216498_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 357.0
TLS2_k127_6216498_1 Oligopeptide/dipeptide transporter, C-terminal region K02031,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002788 284.0
TLS2_k127_6216498_2 SAICAR synthetase K01923,K01945 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005047 309.0
TLS2_k127_6216498_3 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006582 271.0
TLS2_k127_6216498_4 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000271 229.0
TLS2_k127_6216498_5 Biotin-lipoyl like - - - 0.0000000000000000000000000000000000000005451 164.0
TLS2_k127_6231038_0 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 516.0
TLS2_k127_6231038_1 Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000006391 241.0
TLS2_k127_6231038_2 Sortilin, neurotensin receptor 3, - - - 0.00009816 56.0
TLS2_k127_6232992_0 coagulation factor 5 8 type - - - 5.974e-261 842.0
TLS2_k127_6232992_1 Cellobiose phosphorylase K00702 - 2.4.1.20 0.000000000000007779 86.0
TLS2_k127_6245179_0 ATP-dependent DNA helicase RecQ K03169 - 5.99.1.2 3.393e-215 678.0
TLS2_k127_6245179_1 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000004313 192.0
TLS2_k127_6257106_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000004962 246.0
TLS2_k127_6257106_1 COGs COG1680 Beta-lactamase class C and other penicillin binding protein - - - 0.00000000000000000000000000002463 131.0
TLS2_k127_6257106_2 - - - - 0.0000000000000000003279 94.0
TLS2_k127_6268697_0 Amino acid adenylation domain - - - 1.177e-225 724.0
TLS2_k127_6272628_0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000005121 207.0
TLS2_k127_6272628_1 Thioredoxin - - - 0.00005104 51.0
TLS2_k127_629897_0 PD-(D/E)XK nuclease superfamily - - - 0.000000000007097 79.0
TLS2_k127_6316271_0 COG0520 Selenocysteine lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 520.0
TLS2_k127_6316271_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000001307 246.0
TLS2_k127_6327390_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 369.0
TLS2_k127_6327390_1 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.000000000000000000000000000000000007757 154.0
TLS2_k127_6335890_0 ZIP Zinc transporter K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009247 349.0
TLS2_k127_6335890_1 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 290.0
TLS2_k127_6335890_2 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001143 283.0
TLS2_k127_6335890_3 'Cold-shock' DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000005489 204.0
TLS2_k127_6335890_4 - - - - 0.00000000000000000000000000000000000000007908 156.0
TLS2_k127_6335890_5 YceI-like domain - - - 0.000000000000000000000000002103 121.0
TLS2_k127_6335890_6 Aminotransferase class-V - - - 0.00073 44.0
TLS2_k127_6351992_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000005467 244.0
TLS2_k127_6351992_1 PFAM NAD dependent epimerase dehydratase family K07071 - - 0.0000000000000000000000000000000000000007271 150.0
TLS2_k127_6351992_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000006379 121.0
TLS2_k127_6351992_3 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.000000000000000003913 95.0
TLS2_k127_6373947_0 B12 binding domain K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 320.0
TLS2_k127_6373947_1 von Willebrand factor, type A K07114 - - 0.00006917 55.0
TLS2_k127_6402958_0 Non-ribosomal peptide synthetase modules and related - - - 0.0 1417.0
TLS2_k127_6402958_1 COGs COG1020 Non-ribosomal peptide synthetase modules and related protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004555 505.0
TLS2_k127_6403162_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000451 425.0
TLS2_k127_6403162_1 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000015 218.0
TLS2_k127_6405730_0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 1.008e-259 816.0
TLS2_k127_6405730_1 Belongs to the thiolase family K00632 - 2.3.1.16 0.0000000000000000000002258 96.0
TLS2_k127_6410117_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005098 599.0
TLS2_k127_6410117_1 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000000000000000000000000000000000000000001673 233.0
TLS2_k127_6410117_2 TatD family K03424 - - 0.000000000000000000000000000000000000000000000000000000000000007205 230.0
TLS2_k127_6410117_3 PFAM Stage II sporulation protein E (SpoIIE) K07315 - 3.1.3.3 0.00000000000000000000000000000001046 141.0
TLS2_k127_6410117_4 nuclear chromosome segregation - - - 0.000000000000000001567 96.0
TLS2_k127_6410117_5 SEC-C motif - - - 0.00001955 52.0
TLS2_k127_6429471_0 polysaccharide biosynthetic process - - - 0.0000000000000000000000001277 122.0
TLS2_k127_6431504_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 488.0
TLS2_k127_6431504_1 Proton-conducting membrane transporter K12141 - - 0.0006972 44.0
TLS2_k127_6449754_0 RimK-like ATPgrasp N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004481 601.0
TLS2_k127_6449754_1 Glutamate-cysteine ligase family 2(GCS2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 454.0
TLS2_k127_6449754_2 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005483 426.0
TLS2_k127_6449754_3 glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000008788 248.0
TLS2_k127_6449754_4 GHKL domain - - - 0.00000000000000000000000000000000000000000000000000000001374 222.0
TLS2_k127_6449754_5 Trypsin-like serine protease - - - 0.00000000000000000000000000000000000739 156.0
TLS2_k127_6449754_6 Cysteine-rich secretory protein family - - - 0.00000000000000000000000000000005565 140.0
TLS2_k127_6449754_7 COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain K04771 - 3.4.21.107 0.0000000009468 70.0
TLS2_k127_6449754_8 two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 0.00000007374 62.0
TLS2_k127_6449754_9 - - - - 0.0000009754 62.0
TLS2_k127_6461303_0 Archease protein family (MTH1598/TM1083) - - - 0.0000000789 55.0
TLS2_k127_6467207_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 537.0
TLS2_k127_6499481_0 Carbamoyl-phosphate synthetase large chain domain protein K01955 - 6.3.5.5 6.105e-207 656.0
TLS2_k127_6499481_1 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 400.0
TLS2_k127_6499481_2 AIR synthase related protein, N-terminal domain K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000001304 246.0
TLS2_k127_651774_0 Carbamoyltransferase K00612 - - 0.000000000000000000000000000000000000000006952 158.0
TLS2_k127_651774_1 - - - - 0.00000000000000000000000000000000000000006511 173.0
TLS2_k127_6527640_0 D-alanine [D-alanyl carrier protein] ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 611.0
TLS2_k127_6527640_1 phospholipase Carboxylesterase - - - 0.00000000000008806 85.0
TLS2_k127_6535328_0 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006589 309.0
TLS2_k127_6535328_1 - - - - 0.000000000000000000000000000000000000002364 149.0
TLS2_k127_6540441_0 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000005365 222.0
TLS2_k127_6550123_0 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.0000000000000000000000000000000005144 131.0
TLS2_k127_6550123_1 Sigma-70, region 4 K03088 - - 0.0000000000000000001469 96.0
TLS2_k127_6550130_0 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 397.0
TLS2_k127_6550130_1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002193 282.0
TLS2_k127_6550130_2 pfam abc K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005199 268.0
TLS2_k127_6550130_3 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000008657 249.0
TLS2_k127_6550130_4 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.0000000000000000000000000000000000000001405 166.0
TLS2_k127_6550130_5 Aldehyde dehydrogenase family K02618,K15514 - 1.2.1.77,1.2.1.91,3.3.2.12 0.000000000000000000000000009198 112.0
TLS2_k127_6551457_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 483.0
TLS2_k127_6551457_1 Amidinotransferase K01478 - 3.5.3.6 0.000000000000000009738 87.0
TLS2_k127_6565165_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 323.0
TLS2_k127_6565165_1 ATPase or kinase K06925 - - 0.00000000000000000001824 101.0
TLS2_k127_6565165_2 glycoprotease K01409,K14742 GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.00000000000000000002704 104.0
TLS2_k127_6565165_3 Sodium/calcium exchanger protein K07301 - - 0.000000000009776 71.0
TLS2_k127_6565859_0 PFAM Glucose Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 412.0
TLS2_k127_6565859_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 372.0
TLS2_k127_6565859_2 oxidoreductase activity - - - 0.00000000000001397 86.0
TLS2_k127_6565859_3 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.0002425 44.0
TLS2_k127_6577314_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.938e-215 682.0
TLS2_k127_6577314_1 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000684 349.0
TLS2_k127_6577314_2 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001256 304.0
TLS2_k127_6577314_3 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000002484 229.0
TLS2_k127_6577314_4 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000009329 182.0
TLS2_k127_6577314_5 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.0000000000000000000000000000000001152 154.0
TLS2_k127_6579600_0 O-Antigen ligase K02847 - - 0.000000000000000008487 98.0
TLS2_k127_6582950_0 serine protease - - - 0.000000000000000000000000000000000000000000000000000000000000000002942 250.0
TLS2_k127_6582950_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000003381 136.0
TLS2_k127_6582950_2 imidazolonepropionase activity K01443 - 3.5.1.25 0.00000000000000000000001434 111.0
TLS2_k127_6582950_3 Putative zinc-finger - - - 0.0000000000003364 80.0
TLS2_k127_6584202_0 Sortilin, neurotensin receptor 3, - - - 1.042e-212 676.0
TLS2_k127_6584202_1 WD40 repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 662.0
TLS2_k127_6584202_10 GCN5-related N-acetyl-transferase K06975 - - 0.000000000000000002593 88.0
TLS2_k127_6584202_11 Histidine kinase - - - 0.000002442 60.0
TLS2_k127_6584202_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 510.0
TLS2_k127_6584202_3 TonB-dependent Receptor Plug Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 518.0
TLS2_k127_6584202_4 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006167 453.0
TLS2_k127_6584202_5 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009087 419.0
TLS2_k127_6584202_6 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 348.0
TLS2_k127_6584202_7 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005688 326.0
TLS2_k127_6584202_8 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001564 308.0
TLS2_k127_6584202_9 Two component regulator propeller - - - 0.0000000000000000000000000000000000000000157 170.0
TLS2_k127_6588911_0 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 1.337e-220 695.0
TLS2_k127_6588911_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 0.00000000000000000000000000000000000000000000000000000000000001426 222.0
TLS2_k127_6588911_2 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.0000000000000000000000000000000000000000000000000000003932 203.0
TLS2_k127_6588911_3 Belongs to the UPF0403 family - - - 0.0000000000000000000000000000000000000000000004843 173.0
TLS2_k127_6588911_4 Protein of unknown function (DUF423) - - - 0.0000000000000000000000001022 110.0
TLS2_k127_6591022_0 ABC-type multidrug transport system ATPase and permease K18889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 522.0
TLS2_k127_6591022_1 NAD-dependent epimerase dehydratase K07071 - - 0.000000000000000000000000000000000000000000000000000000000009659 233.0
TLS2_k127_6591022_2 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.00000000000000000000000379 108.0
TLS2_k127_6591880_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000001784 215.0
TLS2_k127_6591880_1 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000642 210.0
TLS2_k127_6591880_10 - - - - 0.00000000000000000009182 89.0
TLS2_k127_6591880_2 Thymidine kinase K00857 - 2.7.1.21 0.0000000000000000000000000000000000000000000000000000003944 200.0
TLS2_k127_6591880_3 Enoyl-CoA hydratase/isomerase K13766 - 4.2.1.18 0.0000000000000000000000000000000000000000000000000000142 199.0
TLS2_k127_6591880_4 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED K01091,K01838 - 3.1.3.18,5.4.2.6 0.000000000000000000000000000000000000001741 156.0
TLS2_k127_6591880_5 PFAM Haloacid dehalogenase domain protein hydrolase - - - 0.0000000000000000000000000000000000006117 157.0
TLS2_k127_6591880_6 Thioesterase superfamily K10806 - - 0.000000000000000000000000000000000006774 141.0
TLS2_k127_6591880_7 Sigma-70, region 4 - - - 0.000000000000000000000000000000002761 136.0
TLS2_k127_6591880_8 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000006986 125.0
TLS2_k127_6591880_9 Uncharacterized conserved protein (DUF2203) - - - 0.0000000000000000000003033 100.0
TLS2_k127_6592535_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 418.0
TLS2_k127_6592535_1 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000003002 171.0
TLS2_k127_6594051_0 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000135 258.0
TLS2_k127_6594051_1 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.00000000000000000000000000000006946 139.0
TLS2_k127_6594051_2 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000002196 130.0
TLS2_k127_6594051_3 - - - - 0.0006697 45.0
TLS2_k127_6594435_0 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 0.0000000007195 74.0
TLS2_k127_6594435_1 PD-(D/E)XK nuclease superfamily - - - 0.0000000007437 73.0
TLS2_k127_6596352_0 MacB-like periplasmic core domain - - - 8.066e-204 661.0
TLS2_k127_6596352_1 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 522.0
TLS2_k127_6596352_2 alpha/beta hydrolase fold K22318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 392.0
TLS2_k127_6596352_3 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006424 263.0
TLS2_k127_6596352_4 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000005139 160.0
TLS2_k127_6596352_5 Receptor family ligand binding region K01999 - - 0.00000000000000000005348 104.0
TLS2_k127_6596352_6 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.00000000002526 64.0
TLS2_k127_6598867_0 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000001258 224.0
TLS2_k127_6598867_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000006597 76.0
TLS2_k127_6598999_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 566.0
TLS2_k127_6598999_1 heat shock protein binding K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001615 290.0
TLS2_k127_6598999_2 Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000002365 278.0
TLS2_k127_6598999_3 cheY-homologous receiver domain - - - 0.00000000000000000000000000000003734 142.0
TLS2_k127_6598999_4 TonB dependent receptor K02014,K16089 - - 0.00000000000000000000000001525 123.0
TLS2_k127_6598999_5 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure - - - 0.00000000000000000000000003294 115.0
TLS2_k127_6598999_6 Gas vesicle synthesis protein GvpL/GvpF - - - 0.000000000000000000000000723 119.0
TLS2_k127_6598999_7 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.0000000000000000000000175 113.0
TLS2_k127_6611961_0 AAA domain K07133 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000593 553.0
TLS2_k127_6611961_1 Dioxygenase K00449 - 1.13.11.3 0.00000000000000000000000000000000000000000000000000000000000000001321 230.0
TLS2_k127_6612947_0 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 427.0
TLS2_k127_6612947_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003116 301.0
TLS2_k127_6614399_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 499.0
TLS2_k127_6614399_1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 364.0
TLS2_k127_6614399_2 2 iron, 2 sulfur cluster binding K00334,K00335 - 1.6.5.3 0.0000000000000000000000000000000001266 147.0
TLS2_k127_6614399_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000008015 106.0
TLS2_k127_6614399_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000001004 98.0
TLS2_k127_6615198_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 2.248e-222 741.0
TLS2_k127_6615198_1 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008499 544.0
TLS2_k127_6615198_2 Protein conserved in bacteria K07011 - - 0.0000000000000000000000000000000000000000000001248 180.0
TLS2_k127_6615198_3 - - - - 0.000000000000000000000001077 114.0
TLS2_k127_6615198_4 - - - - 0.0000000000000000000363 93.0
TLS2_k127_6616967_0 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000004796 137.0
TLS2_k127_6616967_1 Tetratricopeptide repeat - - - 0.0000000000000000000000002331 115.0
TLS2_k127_6625860_0 COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 349.0
TLS2_k127_6625860_1 FxsA cytoplasmic membrane protein K07113 - - 0.0000000000000000000000000002316 120.0
TLS2_k127_6626565_0 Dynamin family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005909 544.0
TLS2_k127_6626565_1 Prokaryotic glutathione synthetase, N-terminal domain K01920 - 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000812 376.0
TLS2_k127_6626565_2 DUF1704 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000999 323.0
TLS2_k127_6626565_3 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003829 265.0
TLS2_k127_6626565_4 involved in cell wall biogenesis - - - 0.00000000000000000000000000000000000000000000000000000001137 210.0
TLS2_k127_6626565_6 helix_turn_helix, Lux Regulon - - - 0.0000000000000000008879 93.0
TLS2_k127_6626565_7 Stress-responsive transcriptional regulator - - - 0.000000000000000008595 85.0
TLS2_k127_6637230_0 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 344.0
TLS2_k127_6637230_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005424 323.0
TLS2_k127_6637230_2 Archaea bacterial proteins of unknown function K06921 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 307.0
TLS2_k127_6637230_3 Trypsin-like serine protease - - - 0.00000000000000000000000000000000000000000000000000000000000006162 243.0
TLS2_k127_6637230_4 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.00000000000000000000000000000000000000000000001705 175.0
TLS2_k127_6637230_5 - - - - 0.00000000000000002248 91.0
TLS2_k127_66458_0 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 379.0
TLS2_k127_66458_1 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005436 278.0
TLS2_k127_66458_2 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000004036 181.0
TLS2_k127_66458_3 - - - - 0.00000000007318 72.0
TLS2_k127_6648757_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006613 470.0
TLS2_k127_6648757_1 Beta-Casp domain K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007363 455.0
TLS2_k127_6648757_2 Zn-dependent protease with chaperone function K03799,K06013 - 3.4.24.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007895 441.0
TLS2_k127_6648757_3 helix_turn_helix, Lux Regulon K07693 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001107 282.0
TLS2_k127_6648757_4 Formyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001426 274.0
TLS2_k127_6648757_5 pdz dhr glgf - - - 0.00000000000000000000000000000000000149 158.0
TLS2_k127_6667540_0 Amidohydrolase family - - - 7.042e-234 743.0
TLS2_k127_6667540_1 pfam abc-1 K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 489.0
TLS2_k127_6667540_2 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008693 434.0
TLS2_k127_6667540_3 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 344.0
TLS2_k127_6667540_4 (ABC) transporter, permease K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007242 336.0
TLS2_k127_6667540_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000003489 244.0
TLS2_k127_6667540_6 EDD domain protein, DegV family - - - 0.0000000000000000000000000000000000000000000000000000000001057 233.0
TLS2_k127_6667540_7 Cellulose biosynthesis protein BcsQ - - - 0.00000000000000000000000000000000000000000000000000001319 200.0
TLS2_k127_6667540_8 carboxylic acid catabolic process - - - 0.0000000000000000000000000000000000000000000000000008704 194.0
TLS2_k127_6667540_9 PFAM Class I peptide chain release factor K15034 - - 0.000000000000000000000000000006309 123.0
TLS2_k127_6672666_0 Voltage gated chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 351.0
TLS2_k127_6672666_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 316.0
TLS2_k127_6672666_2 Calcineurin-like phosphoesterase - - - 0.0000000000003817 71.0
TLS2_k127_6672666_3 - - - - 0.000000001611 61.0
TLS2_k127_6672666_4 EF hand - - - 0.0003568 53.0
TLS2_k127_6672906_0 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 355.0
TLS2_k127_6672906_1 MoaC family K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000001872 164.0
TLS2_k127_6673824_0 COG0339 Zn-dependent oligopeptidases K01284 GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.15.5 1.064e-312 971.0
TLS2_k127_6673824_1 Binding-protein-dependent transport system inner membrane component K02037,K02038 - - 0.0000000000000000003491 99.0
TLS2_k127_6678865_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000002271 198.0
TLS2_k127_6678865_1 PFAM Iron permease FTR1 - - - 0.00000000000000000000000000000000000000000163 167.0
TLS2_k127_6692543_0 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000001317 141.0
TLS2_k127_6704230_0 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 4.626e-240 760.0
TLS2_k127_6704230_1 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000964 176.0
TLS2_k127_6704230_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000001594 165.0
TLS2_k127_6704230_3 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000001342 134.0
TLS2_k127_6704230_4 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000006526 139.0
TLS2_k127_6704230_5 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000001955 100.0
TLS2_k127_6704909_0 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 - 4.1.3.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 377.0
TLS2_k127_6704909_1 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008476 307.0
TLS2_k127_6704909_2 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily K01911 - 6.2.1.26 0.00000000000000000000000597 109.0
TLS2_k127_6715276_0 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 523.0
TLS2_k127_6715276_1 Bacterial membrane protein YfhO - - - 0.000000005937 70.0
TLS2_k127_6724967_0 non-ribosomal peptide synthetase - - - 0.0 1193.0
TLS2_k127_6725910_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 451.0
TLS2_k127_6725910_1 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 419.0
TLS2_k127_6725910_2 Mur ligase family, catalytic domain K02558 - 6.3.2.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006887 299.0
TLS2_k127_6725910_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002168 284.0
TLS2_k127_6732207_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 473.0
TLS2_k127_6732207_1 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000003244 245.0
TLS2_k127_6732207_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000001107 224.0
TLS2_k127_6737334_0 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000056 194.0
TLS2_k127_6737334_1 - - - - 0.00000000000000000000000000000002246 147.0
TLS2_k127_6738578_0 COG1960 Acyl-CoA dehydrogenases K00248 - 1.3.8.1 2.065e-249 784.0
TLS2_k127_6738578_1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K07516 - 1.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009051 291.0
TLS2_k127_6738578_2 Trypsin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001163 284.0
TLS2_k127_6738578_3 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000000000182 167.0
TLS2_k127_6738578_4 - - - - 0.00000000000000000000000000006206 123.0
TLS2_k127_674813_0 efflux transmembrane transporter activity - - - 2.845e-211 687.0
TLS2_k127_674813_1 Rhomboid family - - - 0.0000000000000000000000000000002788 126.0
TLS2_k127_6756015_0 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000006258 263.0
TLS2_k127_6756015_1 Ribonuclease HII K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000001502 239.0
TLS2_k127_6756015_2 CHAT domain - - - 0.00000000000000000000000000000000000000000004918 181.0
TLS2_k127_6756015_3 Curli production assembly/transport component CsgG - - - 0.0000000000000000000000000000007241 142.0
TLS2_k127_675747_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 5.874e-204 652.0
TLS2_k127_675747_1 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 308.0
TLS2_k127_675747_10 Predicted membrane protein (DUF2318) K09005 - - 0.00000007183 65.0
TLS2_k127_675747_11 AbrB family - - - 0.0000002482 55.0
TLS2_k127_675747_2 Required for morphogenesis under gluconeogenic growth conditions - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005022 299.0
TLS2_k127_675747_3 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000000002336 222.0
TLS2_k127_675747_4 PFAM Peptidase family S58 - - - 0.00000000000000000000000000000000000000000000000000000000003048 217.0
TLS2_k127_675747_5 PFAM Roadblock LC7 family protein - - - 0.000000000000000000000000000000000000000000000000000000001698 206.0
TLS2_k127_675747_6 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000007635 205.0
TLS2_k127_675747_7 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.000000000000000000000000000000006291 136.0
TLS2_k127_675747_8 PFAM IS1 transposase - - - 0.0000000000000000000003605 98.0
TLS2_k127_675747_9 PIN domain K19686 - - 0.0000000000000000001321 94.0
TLS2_k127_6760071_0 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009857 295.0
TLS2_k127_6760071_1 DNA-templated transcription, initiation K03088 - - 0.000000000000000000003272 108.0
TLS2_k127_6760071_2 - - - - 0.0000000000000002534 87.0
TLS2_k127_6760071_4 YCII-related domain - - - 0.0000000001216 69.0
TLS2_k127_6760071_5 toxic component of a K07171 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:2000112,GO:2000113 - 0.000000004147 63.0
TLS2_k127_6766600_0 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005932 365.0
TLS2_k127_6766600_1 N,N-dimethylaniline monooxygenase activity - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 315.0
TLS2_k127_6766894_0 Formiminotransferase domain K00603,K01746,K13990 - 2.1.2.5,4.3.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000706 254.0
TLS2_k127_6770648_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007162 539.0
TLS2_k127_6770648_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 316.0
TLS2_k127_6770648_2 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 303.0
TLS2_k127_6770648_3 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000002398 268.0
TLS2_k127_6770648_4 Domain of unknown function (DUF4214) - - - 0.000000000000000000000000000000000003676 149.0
TLS2_k127_6770648_5 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000164 107.0
TLS2_k127_6770648_6 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000001704 101.0
TLS2_k127_6770648_7 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000008999 92.0
TLS2_k127_6773139_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 2.676e-262 823.0
TLS2_k127_6773139_1 PFAM Amidohydrolase 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000759 426.0
TLS2_k127_6773139_10 Sugar fermentation stimulation protein K06206 - - 0.000000001039 66.0
TLS2_k127_6773139_11 COG3307 Lipid A core - O-antigen ligase and related enzymes - - - 0.0002519 54.0
TLS2_k127_6773139_12 lipase activity K15349 - - 0.0003245 49.0
TLS2_k127_6773139_2 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 344.0
TLS2_k127_6773139_3 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004436 256.0
TLS2_k127_6773139_4 FtsZ-dependent cytokinesis - - - 0.0000000000000000000000000000000000000000000000005197 191.0
TLS2_k127_6773139_5 - - - - 0.0000000000000000000000000000000000001713 149.0
TLS2_k127_6773139_6 Protein of unknown function (DUF433) - - - 0.000000000000000000000000000000005468 128.0
TLS2_k127_6773139_7 - - - - 0.0000000000000000000000002898 119.0
TLS2_k127_6773139_8 domain, Protein K15125 - - 0.0000000000000000000002186 109.0
TLS2_k127_6773139_9 Transglutaminase-like superfamily - - - 0.0000000000000000004125 94.0
TLS2_k127_6776398_0 Transposase - - - 2.262e-231 743.0
TLS2_k127_6782033_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 537.0
TLS2_k127_6782033_1 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002535 534.0
TLS2_k127_6782033_10 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 314.0
TLS2_k127_6782033_11 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005853 311.0
TLS2_k127_6782033_12 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.0000000000000000000000000000000000000000000000000000001263 220.0
TLS2_k127_6782033_13 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000008993 199.0
TLS2_k127_6782033_14 ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000000000000000000001927 192.0
TLS2_k127_6782033_15 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000004265 165.0
TLS2_k127_6782033_16 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000008281 149.0
TLS2_k127_6782033_17 light absorption K06893 - - 0.000000000000000000000000000000006965 145.0
TLS2_k127_6782033_18 - - - - 0.00000000000000000000000001392 122.0
TLS2_k127_6782033_19 Peptidase M56 - - - 0.0000000000000008504 89.0
TLS2_k127_6782033_2 Ribonuclease E/G family K08300,K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 458.0
TLS2_k127_6782033_20 Protein of unknown function (DUF3467) - - - 0.000000000000006294 89.0
TLS2_k127_6782033_21 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000002137 77.0
TLS2_k127_6782033_22 nuclear chromosome segregation - - - 0.0000000000003352 83.0
TLS2_k127_6782033_23 Bacterial membrane protein, YfhO - - - 0.000000000004213 80.0
TLS2_k127_6782033_24 - - - - 0.00000000001785 68.0
TLS2_k127_6782033_25 C4-type zinc ribbon domain K07164 - - 0.00000001436 69.0
TLS2_k127_6782033_3 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 - 2.7.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 440.0
TLS2_k127_6782033_4 PFAM Peptidase M16 inactive domain K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 436.0
TLS2_k127_6782033_5 imidazolonepropionase activity K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003557 422.0
TLS2_k127_6782033_6 Peptidase, M16 K07263,K07623 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 426.0
TLS2_k127_6782033_7 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 395.0
TLS2_k127_6782033_8 ATPases associated with a variety of cellular activities K01990,K09689,K09691,K09693 - 3.6.3.38,3.6.3.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 356.0
TLS2_k127_6782033_9 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006345 346.0
TLS2_k127_6797276_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000006616 235.0
TLS2_k127_6797276_1 - - - - 0.0000000000000000000000000000000000000000000001339 173.0
TLS2_k127_6802455_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 588.0
TLS2_k127_6802455_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 294.0
TLS2_k127_6802455_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000002247 198.0
TLS2_k127_6802455_3 Forkhead associated domain - - - 0.0000000000000000000000000000000000000000000002698 181.0
TLS2_k127_6802455_4 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000136 158.0
TLS2_k127_6802455_5 Glycosyltransferase like family 2 K07011 - - 0.000000000000000000000000008927 127.0
TLS2_k127_6802455_6 - - - - 0.00000000000000000000000001308 129.0
TLS2_k127_6802455_7 Glycosyltransferase like family 2 K20444 - - 0.000000000000000000000001362 120.0
TLS2_k127_6802455_8 Glycosyl transferase - - - 0.0000000000001933 84.0
TLS2_k127_6802455_9 - - - - 0.000158 45.0
TLS2_k127_6816378_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 6.694e-240 758.0
TLS2_k127_6816378_1 Aldehyde dehydrogenase family K00128,K00135 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008714 439.0
TLS2_k127_6825_0 Ferritin-like K20087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009963 372.0
TLS2_k127_6825_1 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007332 305.0
TLS2_k127_6825_2 COG4206 Outer membrane cobalamin receptor protein K02014,K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001645 289.0
TLS2_k127_6825_3 Pfam SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000008216 178.0
TLS2_k127_6825_4 Cytochrome c - - - 0.000000000000000000000000000000000000004657 162.0
TLS2_k127_6825_5 Domain of unknown function (DUF3536) - - - 0.000000000000000000000000000003452 126.0
TLS2_k127_6825_6 - - - - 0.000000000000000000000000000007314 129.0
TLS2_k127_6825_7 hydroperoxide reductase activity - - - 0.00000000000000000002172 94.0
TLS2_k127_6825_8 hydroperoxide reductase activity - - - 0.000000000222 69.0
TLS2_k127_683245_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.173e-266 843.0
TLS2_k127_683245_1 Penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 531.0
TLS2_k127_683245_10 Protein of unknown function (DUF433) - - - 0.00000000000001276 76.0
TLS2_k127_683245_11 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.000000000008751 79.0
TLS2_k127_683245_13 Ribbon-helix-helix protein, copG family - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.0003695 46.0
TLS2_k127_683245_2 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005918 345.0
TLS2_k127_683245_3 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000002645 164.0
TLS2_k127_683245_4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.0000000000000000000000000000000000002568 144.0
TLS2_k127_683245_5 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000004035 133.0
TLS2_k127_683245_6 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.000000000000000000000000001586 117.0
TLS2_k127_683245_7 Ribosomal protein S18 K02963 - - 0.00000000000000000000000005362 110.0
TLS2_k127_683245_8 Regulatory protein - - - 0.000000000000000000000005215 106.0
TLS2_k127_683245_9 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000003572 90.0
TLS2_k127_6862397_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1202.0
TLS2_k127_6862397_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 3.936e-285 918.0
TLS2_k127_6862397_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008643 301.0
TLS2_k127_6862397_3 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000001075 245.0
TLS2_k127_6867009_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 484.0
TLS2_k127_6867009_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016625,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0047553,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 457.0
TLS2_k127_6867009_2 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 393.0
TLS2_k127_6867009_3 e3 binding domain K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 394.0
TLS2_k127_6867009_4 belongs to the nudix hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007586 376.0
TLS2_k127_6867009_5 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000003542 219.0
TLS2_k127_6867009_6 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000824 198.0
TLS2_k127_6867009_7 PFAM Proprotein convertase P-domain - - - 0.000000000000000000000000000000000001709 161.0
TLS2_k127_6867009_8 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000001012 93.0
TLS2_k127_6867009_9 Belongs to the sulfur carrier protein TusA family - - - 0.0000000000002975 75.0
TLS2_k127_6935507_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003853 323.0
TLS2_k127_6935507_1 Hydroxymethylglutaryl-coenzyme A reductase K00021 - 1.1.1.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 330.0
TLS2_k127_6935507_2 COG1233 Phytoene dehydrogenase and related - - - 0.00000000000000000000000000000000000000000000000000000000000000000002153 264.0
TLS2_k127_6935507_3 pfam abc1 K03688 - - 0.0000000000000000000000000000000000000000000000000000001345 224.0
TLS2_k127_6935507_4 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000001169 214.0
TLS2_k127_6935507_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000008075 137.0
TLS2_k127_6935507_6 ABC transporter K03688 - - 0.000000000000000000000001987 121.0
TLS2_k127_6935507_7 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 5.1.3.2 0.0000000003432 74.0
TLS2_k127_6939991_0 OsmC-like protein K06889,K07397 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 300.0
TLS2_k127_6939991_1 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970,K00974 - 2.7.7.19,2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 295.0
TLS2_k127_6943908_0 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 2.549e-214 673.0
TLS2_k127_6943908_1 SAF K01654 - 2.5.1.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 527.0
TLS2_k127_6943908_2 UDP-N-acetylglucosamine 2-epimerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 411.0
TLS2_k127_6943908_3 COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component K09690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 356.0
TLS2_k127_6943908_4 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 326.0
TLS2_k127_6943908_5 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000004234 239.0
TLS2_k127_6943908_6 Cytidylyltransferase K00983 - 2.7.7.43 0.0000000000000000000000000000000000000000000000000000006602 216.0
TLS2_k127_6943908_7 inositol 2-dehydrogenase activity K18431 - 2.7.7.82 0.0000000000000000000000000000000000000000000000001868 201.0
TLS2_k127_6943908_8 Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC - - - 0.0000000000000000000000000000001013 145.0
TLS2_k127_6943908_9 PFAM Polysaccharide pyruvyl transferase - - - 0.0000000003017 74.0
TLS2_k127_6944506_0 Sortilin, neurotensin receptor 3, - - - 0.0 1026.0
TLS2_k127_6944506_1 - - - - 0.0000000000000000000007123 105.0
TLS2_k127_6944506_2 Lysin motif - - - 0.000000000000000009116 89.0
TLS2_k127_6944506_3 PFAM cytochrome c class III - - - 0.000000000006789 70.0
TLS2_k127_6966754_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008176 437.0
TLS2_k127_6966754_1 PFAM Cobyrinic acid ac-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000299 297.0
TLS2_k127_6966754_10 PFAM single-stranded nucleic acid binding R3H K06346 - - 0.00000000002873 65.0
TLS2_k127_6966754_2 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005104 246.0
TLS2_k127_6966754_3 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000008508 228.0
TLS2_k127_6966754_4 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000008091 200.0
TLS2_k127_6966754_5 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000004826 184.0
TLS2_k127_6966754_6 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.00000000000000000000312 102.0
TLS2_k127_6966754_7 Polymer-forming cytoskeletal - - - 0.00000000000000000006371 104.0
TLS2_k127_6966754_8 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000001563 97.0
TLS2_k127_6966754_9 PFAM OmpA MotB domain protein K03640 - - 0.00000000000000001895 88.0
TLS2_k127_6985658_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 - 3.4.21.83 1.423e-257 809.0
TLS2_k127_6985658_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 1.097e-198 628.0
TLS2_k127_6985658_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 504.0
TLS2_k127_6985658_3 ADP-glyceromanno-heptose 6-epimerase activity K01710,K08678 - 4.1.1.35,4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009048 488.0
TLS2_k127_6985658_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 389.0
TLS2_k127_6985658_5 Male sterility protein K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 342.0
TLS2_k127_6985658_6 Domain of unknown function (DUF374) K09778 - - 0.0000000000000000000000000000000000001062 152.0
TLS2_k127_6985658_7 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887 - 0.00000000000000229 83.0
TLS2_k127_6985658_8 Pfam SNARE associated Golgi protein - - - 0.000000000000008557 84.0
TLS2_k127_6997820_0 Lamin Tail Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 391.0
TLS2_k127_6997820_1 ATPases associated with a variety of cellular activities K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000003689 241.0
TLS2_k127_6997820_2 ABC 3 transport family K09816 - - 0.000000000000000000000000000000000000000000000000000000000000000004634 237.0
TLS2_k127_6997820_3 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000001584 153.0
TLS2_k127_6997820_4 Polysaccharide biosynthesis/export protein K01991 - - 0.0000000000000000000000000000000003694 140.0
TLS2_k127_6997820_5 DNA-templated transcription, initiation K01426,K22278 - 3.5.1.104,3.5.1.4 0.00000005875 67.0
TLS2_k127_7004652_0 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007652 398.0
TLS2_k127_7004652_1 FAD dependent oxidoreductase - - - 0.000000000000000000059 91.0
TLS2_k127_7004652_2 Subtilase family - - - 0.0001514 48.0
TLS2_k127_701006_0 Non-ribosomal peptide synthetase modules and related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007381 397.0
TLS2_k127_701006_1 phosphoesterase, PA-phosphatase related - - - 0.0000000000005259 76.0
TLS2_k127_701028_0 Non-ribosomal peptide synthetase modules and related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 383.0
TLS2_k127_701028_1 phosphoesterase, PA-phosphatase related - - - 0.00000000007579 76.0
TLS2_k127_7019826_0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001668 281.0
TLS2_k127_7019826_1 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000007695 249.0
TLS2_k127_7019826_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000002735 203.0
TLS2_k127_7022586_0 dihydroorotate dehydrogenase activity - - - 0.0000000000000000000000000000000000003622 156.0
TLS2_k127_7022586_1 Virulence factor BrkB K07058 - - 0.00004407 50.0
TLS2_k127_7031783_0 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 458.0
TLS2_k127_7039539_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 2.682e-282 877.0
TLS2_k127_7039539_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.00000000000000000000000000000000000000000005098 164.0
TLS2_k127_7039539_2 RTX toxins and related Ca2 binding proteins - - - 0.00000000000000000000000000001335 138.0
TLS2_k127_7039539_3 - - - - 0.000000000006376 79.0
TLS2_k127_7046837_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 327.0
TLS2_k127_7046837_1 Bacterial PH domain - - - 0.00000000000000000000000000000000000000000000000000003582 201.0
TLS2_k127_7046837_2 Bacterial PH domain K08981 - - 0.000000000000000000000000000000000000007634 149.0
TLS2_k127_7046837_3 Cation efflux family - - - 0.00000000000000000000000000000000004229 151.0
TLS2_k127_7084200_0 Esterase of the alpha-beta hydrolase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 583.0
TLS2_k127_7084200_1 AMP-binding enzyme C-terminal domain K18660,K18661 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 426.0
TLS2_k127_7084200_10 - - - - 0.000001407 53.0
TLS2_k127_7084200_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 339.0
TLS2_k127_7084200_3 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004492 322.0
TLS2_k127_7084200_4 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000006887 247.0
TLS2_k127_7084200_5 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000004707 225.0
TLS2_k127_7084200_6 PFAM Serine threonine protein kinase-related K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000008408 182.0
TLS2_k127_7084200_7 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000001528 151.0
TLS2_k127_7084200_8 - - - - 0.000000000000000000000002263 119.0
TLS2_k127_7084200_9 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000007639 84.0
TLS2_k127_7135402_0 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 399.0
TLS2_k127_7135402_1 xanthine dehydrogenase activity K03519,K19818 - 1.2.5.3,1.5.99.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 289.0
TLS2_k127_7135402_2 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000002857 245.0
TLS2_k127_7135402_3 Eukaryotic-type carbonic anhydrase K01674 - 4.2.1.1 0.000000000000000000000000000000000000000000000006914 185.0
TLS2_k127_7135402_4 - - - - 0.000000000000000000000003163 110.0
TLS2_k127_7141453_0 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 355.0
TLS2_k127_7141453_1 Protein of unknown function (DUF819) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005447 287.0
TLS2_k127_7141453_2 PFAM PfkB domain protein K00856 - 2.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005296 299.0
TLS2_k127_7141453_3 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000002772 217.0
TLS2_k127_7141453_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000001192 95.0
TLS2_k127_7143771_0 Phospholipase D. Active site motifs. K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004816 360.0
TLS2_k127_7143771_1 PFAM NAD dependent epimerase dehydratase family K18981 - 1.1.1.203 0.000000000000000000000000000000000000000000000000000000000000000000003472 249.0
TLS2_k127_7143771_2 Subtilisin-like serine K14645 - - 0.00000000000000000000000000000000000008009 160.0
TLS2_k127_7143771_3 NUDIX domain - - - 0.0000000000000000000000000002164 134.0
TLS2_k127_7143771_4 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.00000000000000000000000002039 119.0
TLS2_k127_7179463_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 302.0
TLS2_k127_7179463_1 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000000001977 147.0
TLS2_k127_7223833_0 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006548 563.0
TLS2_k127_7223833_1 Saccharopine dehydrogenase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 378.0
TLS2_k127_7223833_2 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K14981 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001171 260.0
TLS2_k127_7223833_3 COG0642 Signal transduction histidine kinase K14980 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000006851 233.0
TLS2_k127_7223833_4 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000002246 167.0
TLS2_k127_7223833_5 Sortase family K07284 - 3.4.22.70 0.00000000000000000000000000000000005866 156.0
TLS2_k127_7223833_6 PFAM lipid A biosynthesis domain protein - - - 0.000000000000000000000000000001079 131.0
TLS2_k127_7223833_7 serine-type endopeptidase activity K20276 - - 0.0000000000000000000001353 113.0
TLS2_k127_7223833_8 Abortive infection protein K07052 - - 0.00000000000000003021 92.0
TLS2_k127_7224921_0 ATP-dependent helicase activity K10844 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006261 427.0
TLS2_k127_7224921_1 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000008567 123.0
TLS2_k127_7241197_0 pfam abc K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001722 285.0
TLS2_k127_7241197_1 - - - - 0.00000000000000000000000000000285 136.0
TLS2_k127_7266130_0 negative regulation of protein lipidation K19294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003899 302.0
TLS2_k127_7266130_1 SGNH hydrolase-like domain, acetyltransferase AlgX K19295 - - 0.000000000000000000000000000000000000000000005446 178.0
TLS2_k127_7316996_0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - 4.599e-280 897.0
TLS2_k127_7316996_1 Sodium:solute symporter family K03307 - - 0.00000000000000000000000000000000000000000000000000000000001878 211.0
TLS2_k127_7316996_2 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000000002677 139.0
TLS2_k127_7335484_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1656.0
TLS2_k127_7335484_1 Aminotransferase K14267,K14287 - 2.6.1.17,2.6.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 446.0
TLS2_k127_7335484_2 PFAM adenosine AMP deaminase K01488 - 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 377.0
TLS2_k127_7335484_3 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 319.0
TLS2_k127_7335484_4 Endonuclease containing a URI domain K07461 - - 0.000000000000000000000002389 105.0
TLS2_k127_7368543_0 N-Acetylmuramoyl-L-alanine amidase K01448,K02172 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000001064 256.0
TLS2_k127_7368543_1 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000002927 214.0
TLS2_k127_7368543_10 Domain of unknown function (DUF4349) - - - 0.0001579 55.0
TLS2_k127_7368543_2 - - - - 0.000000000000000000000000000000000002594 154.0
TLS2_k127_7368543_3 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000004225 142.0
TLS2_k127_7368543_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides - - - 0.00000000000000000000000000000001055 147.0
TLS2_k127_7368543_5 Domain of unknown function (DUF4115) - - - 0.00000000000000000000000000005187 129.0
TLS2_k127_7368543_6 - - - - 0.000000000001111 74.0
TLS2_k127_7368543_7 EamA-like transporter family - - - 0.000000000001285 79.0
TLS2_k127_7368543_8 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000003419 75.0
TLS2_k127_7368543_9 - - - - 0.0000000001317 72.0
TLS2_k127_7370265_0 Leukotriene A4 hydrolase, C-terminal - - - 2.772e-226 753.0
TLS2_k127_7370265_1 PFAM membrane bound O-acyl transferase MBOAT family protein K19294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009061 335.0
TLS2_k127_7370265_2 phosphorelay signal transduction system - - - 0.000000000000000003407 99.0
TLS2_k127_7377947_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001787 299.0
TLS2_k127_7377947_1 ASPIC and UnbV - - - 0.0000000000000000003167 92.0
TLS2_k127_7454984_0 oxidoreductase activity - - - 0.00000000004597 76.0
TLS2_k127_7454984_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000005449 63.0
TLS2_k127_773234_0 ABC1 family K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009687 560.0
TLS2_k127_773234_1 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 381.0
TLS2_k127_773234_2 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000000000000002087 84.0
TLS2_k127_780521_0 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01761 - 4.4.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 466.0
TLS2_k127_780521_1 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000002053 208.0
TLS2_k127_780521_2 mRNA cleavage K19158 - - 0.000000000000000000000000002727 116.0
TLS2_k127_780521_3 Antitoxin component of a toxin-antitoxin (TA) module K19159 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015643,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042710,GO:0043565,GO:0044010,GO:0044764,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051704,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000004507 86.0
TLS2_k127_780521_4 PFAM transposase IS204 IS1001 IS1096 IS1165 family protein K07485 - - 0.000000009545 59.0
TLS2_k127_780521_5 Ricin-type beta-trefoil - - - 0.0003282 49.0
TLS2_k127_792187_0 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000005519 191.0
TLS2_k127_792187_1 Methicillin resistance protein - - - 0.00000000000000000000000000000000000007595 146.0
TLS2_k127_792187_2 BlaR1 peptidase M56 - - - 0.00000004149 64.0
TLS2_k127_792187_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0000001224 58.0
TLS2_k127_794648_0 Domain of unknown function (DUF5117) - - - 6.102e-235 761.0
TLS2_k127_794648_1 oligopeptide transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 488.0
TLS2_k127_794648_2 PFAM Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 332.0
TLS2_k127_802568_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004951 402.0
TLS2_k127_802568_1 von Willebrand factor, type A K07114 - - 0.0000000000000000000000004839 122.0
TLS2_k127_823503_0 Cytochrome c - - - 0.0 1203.0
TLS2_k127_823503_1 GMC oxidoreductase - - - 1.074e-284 886.0
TLS2_k127_823503_2 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000844 456.0
TLS2_k127_823503_3 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002459 261.0
TLS2_k127_823503_4 sugar transferase - - - 0.000000000000000000000000000000000000000000000000005357 189.0
TLS2_k127_823503_5 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000003269 168.0
TLS2_k127_823503_6 PFAM O-antigen polymerase - - - 0.0000000000000000000000000000000001433 153.0
TLS2_k127_823503_7 AAA domain K08252 - 2.7.10.1 0.00000007624 63.0
TLS2_k127_825231_0 metal ion transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006894 291.0
TLS2_k127_825231_1 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000104 275.0
TLS2_k127_825231_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000001276 140.0
TLS2_k127_826008_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.512e-246 779.0
TLS2_k127_826008_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 301.0
TLS2_k127_826008_10 PIN domain - - - 0.0006651 43.0
TLS2_k127_826008_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000001356 198.0
TLS2_k127_826008_3 protein conserved in cyanobacteria - - - 0.00000000000000000000000000000000000000000000000004798 186.0
TLS2_k127_826008_4 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000017 121.0
TLS2_k127_826008_5 Histone deacetylase domain K04768 - - 0.00000000000000000000001028 107.0
TLS2_k127_826008_6 ArsR family transcriptional regulator - GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000007832 91.0
TLS2_k127_826008_7 Belongs to the bacterial ribosomal protein bL33 family K02913 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000287 78.0
TLS2_k127_826008_8 - - - - 0.000000003142 65.0
TLS2_k127_826008_9 DNA-templated transcription, initiation K03088 - - 0.00000002573 63.0
TLS2_k127_851323_0 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000008738 210.0
TLS2_k127_851323_1 ABC transporter transmembrane region K11085 - - 0.00000000000000000008891 93.0
TLS2_k127_859193_0 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000009233 278.0
TLS2_k127_87595_0 Dehydrogenase E1 component K00615 - 2.2.1.1 1.929e-288 902.0
TLS2_k127_87595_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 GO:0003674,GO:0003824,GO:0003952,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 8.443e-265 824.0
TLS2_k127_879700_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 2.765e-206 651.0
TLS2_k127_879700_1 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000003615 224.0
TLS2_k127_917589_0 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 354.0
TLS2_k127_917589_1 PFAM N-acetylmuramoyl-L-alanine amidase family 2 K03806 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000109 280.0
TLS2_k127_917589_2 FAD dependent oxidoreductase K15736 - - 0.000000000000000000000000000000000157 136.0
TLS2_k127_917589_3 - - - - 0.000003068 51.0
TLS2_k127_917589_4 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.00005401 46.0
TLS2_k127_917619_0 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005993 402.0
TLS2_k127_917619_1 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 367.0
TLS2_k127_917619_2 PFAM N-acetylmuramoyl-L-alanine amidase family 2 K03806 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000341 284.0
TLS2_k127_917619_3 - - - - 0.00003916 48.0
TLS2_k127_917619_4 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.00008775 46.0
TLS2_k127_935976_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1118.0
TLS2_k127_935976_1 Cysteine synthase K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 303.0
TLS2_k127_935976_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000008303 189.0
TLS2_k127_935976_3 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000001958 161.0
TLS2_k127_935976_4 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000004624 134.0
TLS2_k127_935976_5 - - - - 0.000000000000000000000000000002233 141.0
TLS2_k127_935976_6 exo-alpha-(2->6)-sialidase activity K12373 - 3.2.1.52 0.0000000000000000000001995 112.0
TLS2_k127_935976_7 D-alanine [D-alanyl carrier protein] ligase activity K16428,K16429 - - 0.0002519 53.0
TLS2_k127_945983_0 TonB dependent receptor - - - 3.354e-211 691.0
TLS2_k127_945983_1 ABC transporter substrate-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009738 462.0
TLS2_k127_945983_2 ABC-type sugar transport systems, permease components K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000587 342.0
TLS2_k127_945983_3 ABC-type sugar transport system, permease component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 329.0
TLS2_k127_945983_4 LacI family K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 306.0
TLS2_k127_945983_5 Putative glucoamylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001338 285.0
TLS2_k127_947057_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 333.0
TLS2_k127_947057_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009972 305.0
TLS2_k127_947057_10 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000001009 164.0
TLS2_k127_947057_11 non-canonical purine NTP pyrophosphatase, RdgB HAM1 family K02428 - 3.6.1.66 0.00000000000000000000000000000001098 134.0
TLS2_k127_947057_12 PFAM membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.00000000000000000000000000000002513 145.0
TLS2_k127_947057_13 STAS domain - - - 0.000000000003607 74.0
TLS2_k127_947057_14 PFAM CBS domain containing protein - - - 0.000000000008134 70.0
TLS2_k127_947057_15 SNARE associated Golgi protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000005042 64.0
TLS2_k127_947057_17 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000006541 53.0
TLS2_k127_947057_18 Protein of unknown function (DUF2892) - - - 0.00003361 53.0
TLS2_k127_947057_19 chitinase K03791,K17733 - - 0.0006451 50.0
TLS2_k127_947057_2 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005858 293.0
TLS2_k127_947057_3 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001129 283.0
TLS2_k127_947057_4 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002646 286.0
TLS2_k127_947057_5 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000002388 211.0
TLS2_k127_947057_6 mechanosensitive ion channel K03442 - - 0.000000000000000000000000000000000000000000000000000001098 206.0
TLS2_k127_947057_7 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000004747 195.0
TLS2_k127_947057_8 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044464,GO:0071944 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000005313 182.0
TLS2_k127_947057_9 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.000000000000000000000000000000000000000000005376 181.0
TLS2_k127_949789_0 DNA ligase K01971 - 6.5.1.1 5.962e-224 724.0
TLS2_k127_949789_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001336 265.0
TLS2_k127_949789_2 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000001471 243.0
TLS2_k127_949789_3 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000003595 211.0
TLS2_k127_949789_4 Sulfatase - - - 0.0000000000000000000000000000000000000000000001471 186.0
TLS2_k127_949789_5 EamA-like transporter family - - - 0.00000000000004652 84.0
TLS2_k127_949789_6 PFAM regulatory protein TetR - - - 0.000000000007159 74.0
TLS2_k127_949789_7 COG0671 Membrane-associated phospholipid phosphatase - - - 0.0000000001724 72.0
TLS2_k127_949789_8 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.0007747 43.0
TLS2_k127_951427_0 Angiotensin-converting enzyme K01283 - 3.4.15.1 1.641e-223 710.0
TLS2_k127_951427_1 Aminotransferase K00812 - 2.6.1.1 0.00000007335 54.0
TLS2_k127_9548_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.195e-236 754.0
TLS2_k127_9548_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 2.763e-228 738.0
TLS2_k127_9548_2 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 477.0
TLS2_k127_9548_3 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 461.0
TLS2_k127_9548_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007172 292.0
TLS2_k127_9548_5 tRNA 3'-trailer cleavage K00784,K01120 - 3.1.26.11,3.1.4.17 0.0000000000000000000000000000000000000000000000000000000000000001966 229.0
TLS2_k127_9548_6 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.00000000000000000000000000000000000000000000000000000000000001861 235.0
TLS2_k127_9548_7 beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000006857 212.0
TLS2_k127_9548_8 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000005968 95.0
TLS2_k127_963206_0 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 425.0
TLS2_k127_963206_1 oxidoreductase activity - - - 0.000000002347 69.0
TLS2_k127_967720_0 Type ii and iii secretion system protein K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 335.0
TLS2_k127_967720_1 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000000000000000000000003561 148.0
TLS2_k127_968487_0 Outer membrane receptor K02014,K16087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002576 375.0
TLS2_k127_968487_1 pfam abc K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002524 293.0
TLS2_k127_968487_2 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000001177 207.0
TLS2_k127_975165_0 Sodium:alanine symporter family K03310 - - 6.336e-220 697.0
TLS2_k127_975165_1 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 415.0
TLS2_k127_975165_2 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000007218 231.0
TLS2_k127_975165_3 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000004878 231.0
TLS2_k127_975165_4 Arginase family K01480 - 3.5.3.11 0.00000001832 56.0
TLS2_k127_975324_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 1.114e-279 876.0
TLS2_k127_975324_1 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000003292 163.0
TLS2_k127_975324_2 protein kinase activity - - - 0.000000000000000000000000000000000000001175 168.0
TLS2_k127_975324_3 Curli production assembly/transport component CsgG - - - 0.00000000000000000000000004338 117.0
TLS2_k127_979334_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 292.0
TLS2_k127_979334_1 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000004041 246.0
TLS2_k127_979334_2 Ferredoxin - - - 0.000000000000000002437 90.0
TLS2_k127_979334_3 - - - - 0.000000002909 70.0
TLS2_k127_981141_0 NAD(P)-binding Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007515 575.0
TLS2_k127_981141_1 PFAM Aminotransferase class I and II K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 534.0
TLS2_k127_981141_2 RmlD substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 300.0
TLS2_k127_982858_0 glycine betaine L-proline K05847 - - 0.000000000000000000000000000000000000000000000000000000004284 207.0
TLS2_k127_982858_1 OsmC-like protein K06889,K07397 - - 0.00000000000000000000000000000000000000000000000002086 188.0
TLS2_k127_982858_2 Diguanylate cyclase - - - 0.0000000000000000000000000000000000001661 162.0
TLS2_k127_987723_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 535.0
TLS2_k127_987723_1 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 463.0
TLS2_k127_987723_10 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.000000000000000000000000004065 117.0
TLS2_k127_987723_11 phosphocarrier protein HPr K11189 - - 0.000000000000000000007533 101.0
TLS2_k127_987723_12 SMART Tetratricopeptide - - - 0.00000000001811 76.0
TLS2_k127_987723_14 Ketoacyl-synthetase C-terminal extension - - - 0.000197 53.0
TLS2_k127_987723_2 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003958 402.0
TLS2_k127_987723_3 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit K01962,K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 381.0
TLS2_k127_987723_4 Single-stranded-DNA-specific exonuclease recj K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 362.0
TLS2_k127_987723_5 PFAM ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005605 317.0
TLS2_k127_987723_6 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 301.0
TLS2_k127_987723_7 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001152 287.0
TLS2_k127_987723_8 CarD-like/TRCF domain K07736 - - 0.000000000000000000000000000000000003279 143.0
TLS2_k127_987723_9 PTS fructose transporter subunit IIA K02793 - 2.7.1.191 0.0000000000000000000000000004621 120.0
TLS2_k127_987824_0 Belongs to the MurCDEF family K01924 GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008726 455.0
TLS2_k127_987824_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 346.0
TLS2_k127_987824_2 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000001953 181.0
TLS2_k127_987824_3 Cell division protein FtsQ K03589 - - 0.0000000001096 75.0
TLS2_k127_988087_0 ABC transporter, transmembrane K18890 - - 7.073e-196 630.0
TLS2_k127_988087_1 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 525.0
TLS2_k127_988087_10 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane K00247 - - 0.000000000000000000000002726 108.0
TLS2_k127_988087_11 Bacterial membrane protein YfhO - - - 0.00000000000000000003875 106.0
TLS2_k127_988087_12 Regulatory protein, FmdB - - - 0.00000000000000000009817 96.0
TLS2_k127_988087_13 Domain of unknown function (DUF4388) - - - 0.0000000000004508 80.0
TLS2_k127_988087_14 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane K00246 - - 0.0000000002301 62.0
TLS2_k127_988087_15 - - - - 0.00004849 48.0
TLS2_k127_988087_2 response regulator K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 481.0
TLS2_k127_988087_3 Type II secretion system (T2SS), protein F K02455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005048 429.0
TLS2_k127_988087_4 phosphorelay sensor kinase activity K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000006668 282.0
TLS2_k127_988087_5 Molybdenum cofactor synthesis domain protein K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000001124 243.0
TLS2_k127_988087_6 PIN domain - - - 0.000000000000000000000000000000000000000000000000000000000000004723 222.0
TLS2_k127_988087_7 Two component regulator propeller - - - 0.000000000000000000000000000000000000000000007055 185.0
TLS2_k127_988087_8 - - - - 0.00000000000000000000000000000000000000001475 165.0
TLS2_k127_988087_9 Xanthine and CO dehydrogenases maturation factor XdhC CoxF family K07402 - - 0.000000000000000000000000000000000002538 148.0
TLS2_k127_988094_0 xanthine dehydrogenase activity K04108 - 1.3.7.9 5.493e-275 868.0
TLS2_k127_988618_0 Nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000008206 211.0
TLS2_k127_988618_1 Putative phosphatase (DUF442) - - - 0.000000000000000000000000001168 122.0
TLS2_k127_988618_2 Transcriptional regulator PadR-like family - - - 0.0000000000005705 70.0
TLS2_k127_988618_3 Acetyltransferase (GNAT) domain - - - 0.00000001764 59.0
TLS2_k127_993227_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 451.0
TLS2_k127_993227_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004718 444.0
TLS2_k127_993227_10 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000001329 126.0
TLS2_k127_993227_11 Protein of unknown function (DUF1232) - - - 0.00000000000000000000000000713 119.0
TLS2_k127_993227_12 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000001514 111.0
TLS2_k127_993227_13 GAF domain - - - 0.0000000000000000000004741 109.0
TLS2_k127_993227_14 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000000158 100.0
TLS2_k127_993227_15 DNA-binding transcription factor activity K02274 - 1.9.3.1 0.000000000000000793 92.0
TLS2_k127_993227_16 Domain of unknown function (DUF4412) - - - 0.000000000000001152 86.0
TLS2_k127_993227_17 Plasmid stability protein K21495 - - 0.0000000000003655 72.0
TLS2_k127_993227_2 Domain of unknown function (DUF3471) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 456.0
TLS2_k127_993227_3 peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 428.0
TLS2_k127_993227_4 PFAM Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 432.0
TLS2_k127_993227_5 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744,K09774,K22110 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009279,GO:0015267,GO:0015288,GO:0015749,GO:0015750,GO:0015751,GO:0015757,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0046323,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1904659 - 0.0000000000000000000000000000000000000000000000000000000000004858 237.0
TLS2_k127_993227_6 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000005177 231.0
TLS2_k127_993227_7 Polysaccharide biosynthesis protein K15856 - 1.1.1.281 0.000000000000000000000000000000000000000000000000000000002064 223.0
TLS2_k127_993227_8 protein conserved in cyanobacteria - - - 0.000000000000000000000000000000000000000007007 158.0
TLS2_k127_993227_9 PFAM Integral membrane protein DUF92 - GO:0005575,GO:0016020 - 0.0000000000000000000000000003654 131.0
TLS2_k127_993943_0 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 381.0
TLS2_k127_993943_1 Oxidoreductase NAD-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000017 223.0
TLS2_k127_993943_2 domain, Protein K15125 - - 0.000000000000000000000000000002023 139.0
TLS2_k127_993943_3 Dystroglycan-type cadherin-like domains. - - - 0.00000008822 63.0
TLS2_k127_995760_0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 603.0
TLS2_k127_995760_1 PFAM deoxyribose-phosphate aldolase phospho-2- dehydro-3-deoxyheptonate aldolase K11645 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 532.0
TLS2_k127_995760_2 shikimate 3-dehydrogenase (NADP+) activity K00014,K13832 GO:0000166,GO:0003674,GO:0003824,GO:0003855,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25,4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005158 323.0
TLS2_k127_995760_3 Protein of unknown function (DUF819) - - - 0.00000000000000000000000000000000000000000000000000000000000000000005153 245.0
TLS2_k127_995760_4 Putative adhesin - - - 0.0000000000000001368 90.0
TLS2_k127_995760_5 membrane transporter protein - - - 0.000000000001595 79.0